D. Hebert

发表

ERAD substrates: which way out?

Riccardo Bernasconi, M. Molinari, D. Hebert, 2010, Seminars in cell & developmental biology.

Viroporins customize host cells for efficient viral propagation.

Kristina M. Giorda, D. Hebert, 2013, DNA and cell biology.

Glucose trimming and reglucosylation determine glycoprotein association with calnexin in the endoplasmic reticulum

Ari Helenius, A. Helenius, D. Hebert, 1995, Cell.

You got to know when to hold (or unfold) 'em….

L. Gierasch, D. Hebert, K. Chandrasekhar, 2012, Molecular cell.

Releasethe Nuclear Envelope for Viral The Simian Virus 40 Late Viral Protein VP4

Kristina M. Giorda, D. Hebert, Smita Raghava, 2012 .

The Simian Virus 40 Late Viral Protein VP4 Disrupts the Nuclear Envelope for Viral Release

Kristina M. Giorda, D. Hebert, Smita Raghava, 2012, Journal of Virology.

11 - Calnexin, Calreticulin, and Their Associated Oxidoreductase ERp57

D. Hebert, B. Pearse, 2007 .

Calnexin and calreticulin promote folding, delay oligomerization and suppress degradation of influenza hemagglutinin in microsomes.

A. Helenius, D. Hebert, B. Foellmer, 1996, The EMBO journal.

Reglucosylation by UDP-glucose:glycoprotein glucosyltransferase 1 delays glycoprotein secretion but not degradation

D. Hebert, Abla Tannous, Taku Tamura, 2015, Molecular biology of the cell.

Sorting things out through endoplasmic reticulum quality control

D. Hebert, Taku Tamura, Johan C. Sunryd, 2010, Molecular membrane biology.

Lectin chaperones help direct the maturation of glycoproteins in the endoplasmic reticulum.

D. Hebert, B. Pearse, 2010, Biochimica et biophysica acta.

TPR-containing proteins control protein organization and homeostasis for the endoplasmic reticulum

D. Hebert, Jill B. Graham, Nathan P. Canniff, 2019, Critical reviews in biochemistry and molecular biology.

ER transmembrane protein TMTC3 contributes to O-mannosylation of E-cadherin, Cellular Adherence and Embryonic Gastrulation

D. Hebert, A. Halim, H. Clausen, 2019, bioRxiv.

Endoplasmic reticulum transmembrane protein TMTC3 contributes to O-mannosylation of E-cadherin, cellular adherence, and embryonic gastrulation

D. Hebert, A. Halim, H. Clausen, 2019, Molecular biology of the cell.

Carbohydrates Direct the Maturation and Trafficking of Glycoproteins in the Secretory Pathway

D. Hebert, Nathan P. Canniff, K. Guay, 2022, Reference Module in Life Sciences.

The Number and Location of Glycans on Influenza Hemagglutinin Determine Folding and Association with Calnexin and Calreticulin

Wei R. Chen, A. Helenius, D. Hebert, 1997, The Journal of cell biology.

Seminars in Cell & Developmental Biology

Riccardo Bernasconi, M. Molinari, D. Hebert, 2010 .

Involved in Calcium Homeostasis Repeat-containing Adapter Proteins

Kristina M. Giorda, D. Hebert, R. Fissore, 2014 .

Protein folding in the endoplasmic reticulum.

D. Hebert, I. Braakman, 2013, Cold Spring Harbor perspectives in biology.

The intrinsic and extrinsic effects of N-linked glycans on glycoproteostasis.

J. Kelly, E. Powers, D. Hebert, 2014, Nature chemical biology.

A cell-based reglucosylation assay demonstrates the role of GT1 in the quality control of a maturing glycoprotein

D. Hebert, B. Pearse, L. Gabriel, 2008, The Journal of cell biology.

Proper Folding and Endoplasmic Reticulum to Golgi Transport of Tyrosinase Are Induced by Its Substrates, DOPA and Tyrosine*

R. Halaban, E. Cheng, D. Hebert, 2001, The Journal of Biological Chemistry.

Post-translational folding of influenza hemagglutinin in isolated endoplasmic reticulum-derived microsomes.

A. Helenius, D. Hebert, T. Marquardt, 1993, The Journal of biological chemistry.

The role of UDP-Glc:glycoprotein glucosyltransferase 1 in the maturation of an obligate substrate prosaposin

R. Kaufman, D. Hebert, G. Grabowski, 2010, The Journal of cell biology.

Simian Virus 40 Late Proteins Possess Lytic Properties That Render Them Capable of Permeabilizing Cellular Membranes

D. Hebert, N. Rusan, P. Wadsworth, 2006, Journal of Virology.

Flagging and docking: dual roles for N-glycans in protein quality control and cellular proteostasis

M. Molinari, D. Hebert, 2012, Trends in Biochemical Sciences.

Yos9p: a sweet-toothed bouncer of the secretory pathway.

D. Hebert, B. Pearse, James H. Cormier, 2005, Molecular cell.

A quinolin-8-ol sub-millimolar inhibitor of UGGT, the ER glycoprotein folding quality control checkpoint

Carlos P. Modenutti, S. Withers, P. Roversi, 2022, bioRxiv.

Effects of Calcium, ATP, and Lipids on Human Erythrocyte Sugar Transport a

D. Hebert, A. Carruthers, A. Helgerson, 1989, Annals of the New York Academy of Sciences.

Cotranslocational degradation: utilitarianism in the ER stress response.

D. Hebert, B. Pearse, 2006, Molecular cell.

Activating and Repressing IRE1α: The Hsp47 and BiP Tug of War.

D. Hebert, Lydia Lamriben, 2018, Molecular cell.

Secretion of functional α1-antitrypsin is cell type dependent: Implications for intramuscular delivery for gene therapy

T. Flotte, L. Gierasch, A. Gershenson, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Glucose transporter oligomeric structure determines transporter function. Reversible redox-dependent interconversions of tetrameric and dimeric GLUT1.

D. Hebert, A. Carruthers, 1992, The Journal of biological chemistry.

Evidence that functional erythrocyte-type glucose transporters are oligomers.

D. Hebert, M. Czech, J. Buxton, 1991, The Journal of biological chemistry.

Uniporters and anion antiporters.

D. Hebert, A. Carruthers, 1991, Current opinion in cell biology.

SV40 VP2 and VP3 insertion into ER membranes is controlled by the capsid protein VP1: implications for DNA translocation out of the ER.

D. Hebert, N. Rusan, P. Wadsworth, 2006, Molecular cell.

SV40 late protein VP4 forms toroidal pores to disrupt membranes for viral release.

Kristina M. Giorda, D. Hebert, Smita Raghava, 2013, Biochemistry.

Direct evidence for ATP modulation of sugar transport in human erythrocyte ghosts.

D. Hebert, A. Carruthers, 1986, The Journal of biological chemistry.

N-linked carbohydrates act as lumenal maturation and quality control protein tags

D. Hebert, R. Daniels, S. Svedine, 2007, Cell Biochemistry and Biophysics.

Abnormal Acidification of Melanoma Cells Induces Tyrosinase Retention in the Early Secretory Pathway*

R. Halaban, E. Cheng, D. Hebert, 2002, The Journal of Biological Chemistry.

In and out of the ER: protein folding, quality control, degradation, and related human diseases.

M. Molinari, D. Hebert, 2007, Physiological reviews.

Tyrosinase Maturation through the Mammalian Secretory Pathway: Bringing Color to Life

D. Hebert, Ning Wang, 2022 .

Tyrosinase Maturation and Oligomerization in the Endoplasmic Reticulum Require a Melanocyte-specific Factor*

R. Halaban, D. Hebert, H. Parag, 2003, Journal of Biological Chemistry.

The cotranslational maturation of the type I membrane glycoprotein tyrosinase: the heat shock protein 70 system hands off to the lectin-based chaperone system.

D. Hebert, R. Daniels, Ning Wang, 2005, Molecular biology of the cell.

Aberrant retention of tyrosinase in the endoplasmic reticulum mediates accelerated degradation of the enzyme and contributes to the dedifferentiated phenotype of amelanotic melanoma cells.

R. Halaban, E. Cheng, D. Hebert, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Carbohydrates act as sorting determinants in ER-associated degradation of tyrosinase

R. Halaban, D. Hebert, Tao Wang, 2004, Journal of Cell Science.

Endoplasmic reticulum retention is a common defect associated with tyrosinase-negative albinism.

R. Halaban, E. Cheng, D. Hebert, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Coexpression of wild-type tyrosinase enhances maturation of temperature-sensitive tyrosinase mutants.

R. Halaban, E. Cheng, D. Hebert, 2002, The Journal of investigative dermatology.

Translation Rate of Human Tyrosinase Determines ItsN-Linked Glycosylation Level*

T. Eisenhaure, R. Halaban, E. Cheng, 2001, The Journal of Biological Chemistry.

N‐Glycan‐based ER Molecular Chaperone and Protein Quality Control System: The Calnexin Binding Cycle

D. Hebert, Jill B. Graham, Lydia Lamriben, 2016, Traffic.

The Cotranslational Maturation Program for the Type II Membrane Glycoprotein Influenza Neuraminidase*

D. Hebert, S. Murphy, B. Pearse, 2008, Journal of Biological Chemistry.

N-linked glycans direct the cotranslational folding pathway of influenza hemagglutinin.

D. Hebert, R. Daniels, A. Johnson, 2003, Molecular cell.

The glycan code of the endoplasmic reticulum: asparagine-linked carbohydrates as protein maturation and quality-control tags.

M. Molinari, D. Hebert, S. Garman, 2005, Trends in cell biology.

N-linked sugar-regulated protein folding and quality control in the ER.

M. Molinari, D. Hebert, Abla Tannous, 2015, Seminars in cell & developmental biology.

Quantitative glycoproteomics reveals cellular substrate selectivity of the ER protein quality control sensors UGGT1 and UGGT2

D. Hebert, I. B. Larsen, Nathan P. Canniff, 2020, bioRxiv.

West Nile Virus Infection Activates the Unfolded Protein Response, Leading to CHOP

P. Mason, D. Ron, M. Molinari, 2007 .

A Very Late Viral Protein Triggers the Lytic Release of SV40

Robert Daniels, D. Hebert, R. Daniels, 2007, PLoS pathogens.

Protein Translocons Multifunctional Mediators of Protein Translocation across Membranes

D. Hebert, D. Schnell, 2003, Cell.

The Viroporin Activity of the Minor Structural Proteins VP2 and VP3 Is Required for SV40 Propagation*

Kristina M. Giorda, D. Hebert, Smita Raghava, 2012, The Journal of Biological Chemistry.

The SV40 Late Protein VP4 Is a Viroporin that Forms Pores to Disrupt Membranes for Viral Release

Kristina M. Giorda, D. Hebert, Smita Raghava, 2011, PLoS pathogens.

The Role of Endoplasmic Reticulum Chaperones in Protein Folding and Quality Control.

D. Hebert, Nathan P. Canniff, Benjamin M. Adams, 2021, Progress in molecular and subcellular biology.

Endoplasmic Reticulum Degradation–Enhancing α‐Mannosidase–like Protein 1 Targets Misfolded HLA–B27 Dimers for Endoplasmic Reticulum–Associated Degradation

Elaine C. Campbell, Amy R. Cameron, D. Guiliano, 2014, Arthritis & rheumatology.

Cellular folding pathway of a metastable serpin

L. Gierasch, A. Gershenson, D. Hebert, 2016, Proceedings of the National Academy of Sciences.

EDEM1 targets misfolded HLA-B27 dimers for endoplasmic reticulum associated degradation

Elaine C. Campbell, Amy R. Cameron, D. Guiliano, 2015 .

Glucose transporter function is controlled by transporter oligomeric structure. A single, intramolecular disulfide promotes GLUT1 tetramerization.

D. Hebert, A. Carruthers, E. K. Cloherty, 1995, Biochemistry.

TMTC1 and TMTC2 Are Novel Endoplasmic Reticulum Tetratricopeptide Repeat-containing Adapter Proteins Involved in Calcium Homeostasis*

Kristina M. Giorda, D. Hebert, R. Fissore, 2014, The Journal of Biological Chemistry.

Small Molecule Targets Env for Endoplasmic Reticulum-Associated Protein Degradation and Inhibits Human Immunodeficiency Virus Type 1 Propagation

D. Hebert, R. Daniels, A. Vahlne, 2009, Journal of Virology.

Characterization of Early EDEM1 Protein Maturation Events and Their Functional Implications*

D. Hebert, Taku Tamura, J. Cormier, 2011, The Journal of Biological Chemistry.

Glycan-dependent and -independent Association of Vesicular Stomatitis Virus G Protein with Calnexin*

A. Helenius, D. Hebert, Kurt S. Cannon, 1996, The Journal of Biological Chemistry.

EDEM1 recognition and delivery of misfolded proteins to the SEL1L-containing ERAD complex.

D. Hebert, Taku Tamura, Johan C. Sunryd, 2009, Molecules and Cells.

Sweet bays of ERAD.

D. Hebert, Taku Tamura, J. Cormier, 2008, Trends in biochemical sciences.

Analysis of Disulfide Bond Formation

D. Hebert, I. Braakman, Lydia Lamriben, 1996, Current protocols in protein science.

EDEM1's mannosidase-like domain binds ERAD client proteins in a redox-sensitive manner and possesses catalytic activity

D. Hebert, H. Clausen, Zhang Yang, 2018, Journal of Biological Chemistry.

EDEM 1 redox sensitive binding and catalytic activity 1 EDEM 1 ’ s mannosidase-like domain binds ERAD client proteins in a redox-sensitive manner and possesses catalytic activity

D. Hebert, H. Clausen, Zhang Yang, 2018 .

Calnexin, calreticulin, and Bip/Kar2p in protein folding.

J. Simons, A. Helenius, D. Hebert, 1995, Cold Spring Harbor symposia on quantitative biology.

EDEM an ER quality control receptor

D. Hebert, Tao Wang, 2003, Nature Structural Biology.

Proper secretion of the serpin antithrombin relies strictly on thiol-dependent quality control

L. Gierasch, A. Gershenson, D. Hebert, 2019, The Journal of Biological Chemistry.

Protein Quality Control in the Endoplasmic Reticulum

D. Hebert, Benjamin M. Adams, Michela E Oster, 2019, The Protein Journal.

The molecular dating game: an antibody heavy chain hangs loose with a chaperone while waiting for its life partner.

L. Gierasch, D. Hebert, 2009, Molecular cell.

Characterization of two independent modes of action of ATP on human erythrocyte sugar transport.

D. Hebert, A. Carruthers, A. Helgerson, 1989, Biochemistry.

The conformational landscape of a serpin N-terminal subdomain facilitates folding and in-cell quality control

L. Gierasch, P. Wintrode, A. Gershenson, 2023, bioRxiv.

Division of Labor: ER-Resident BiP Co-Chaperones Match Substrates to Fates Based on Specific Binding Sequences.

L. Gierasch, D. Hebert, E. Clerico, 2016, Molecular cell.

Cholate-solubilized erythrocyte glucose transporters exist as a mixture of homodimers and homotetramers.

D. Hebert, A. Carruthers, 1991, Biochemistry.

Protein unfolding: mitochondria offer a helping hand

D. Hebert, 1999, Nature Structural Biology.

Protein quality control—linking the unfolded protein response to disease

D. Cyr, D. Hebert, 2009, EMBO reports.

Glycoprotein maturation and quality control.

M. Molinari, D. Hebert, 2015, Seminars in Cell and Developmental Biology.

Chaperones of the Endoplasmic Reticulum Associated Degradation (ERAD) Pathway

D. Hebert, Abla Tannous, Johan C. Sunryd, 2014 .

Rescue of secretion of a rare-disease associated mis-folded mutant glycoprotein in UGGT1 knock-out mammalian cells

P. Roversi, M. Molinari, D. Hebert, 2023, bioRxiv.

EDEM1 reveals a quality control vesicular transport pathway out of the endoplasmic reticulum not involving the COPII exit sites

D. Hebert, J. Roth, C. Zuber, 2007, Proceedings of the National Academy of Sciences.

An MBoC Favorite: Malectin: a novel carbohydrate-binding protein of the endoplasmic reticulum and a candidate player in the early steps of protein N-glycosylation

D. Hebert, 2012, Molecular biology of the cell.

Calnexin reveals a sugar‐free taste within the lipid bilayer

D. Hebert, Kevin P Guay, Robert V Williams, 2022, The EMBO journal.

Analysis of Protein Folding and Oxidation in the Endoplasmic Reticulum

D. Hebert, R. Daniels, Edwin Francis, 2002, Current protocols in cell biology.

A cell-based reglucosylation assay demonstrates the role of GT1 in the quality control of a maturing glycoprotein

D. Hebert, B. Pearse, L. Gabriel, 2008, The Journal of cell biology.

Analysis of Disulfide Bond Formation

D. Hebert, I. Braakman, 1996, Current protocols in protein science.

Faculty Opinions recommendation of Genome-wide CRISPR Analysis Identifies Substrate-Specific Conjugation Modules in ER-Associated Degradation.

D. Hebert, 2019, Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature.

ERAD substrates: which way out?

Riccardo Bernasconi, M. Molinari, D. Hebert, 2010, Seminars in cell & developmental biology.

Characterization of Early EDEM1 Protein Maturation Events and Their Functional Implications*

D. Hebert, Taku Tamura, J. Cormier, 2011, The Journal of Biological Chemistry.

EDEM1's mannosidase-like domain binds ERAD client proteins in a redox-sensitive manner and possesses catalytic activity

D. Hebert, H. Clausen, Zhang Yang, 2018, The Journal of Biological Chemistry.

Endoplasmic Reticulum Degradation–Enhancing α‐Mannosidase–like Protein 1 Targets Misfolded HLA–B27 Dimers for Endoplasmic Reticulum–Associated Degradation

Elaine C. Campbell, Amy R. Cameron, D. Nesbeth, 2014, Arthritis & rheumatology.

Lectin Chaperones Help Direct the Maturation of Glycoproteins in the Endoplasmic Reticulum

D. Hebert, B. Pearse, 2022 .

The Viroporin Activity of the Minor Structural Proteins VP2 and VP3 Is Required for SV40 Propagation*

Kristina M. Giorda, D. Hebert, Smita Raghava, 2012, The Journal of Biological Chemistry.

Rescue of secretion of a rare-disease associated mis-folded mutant glycoprotein in UGGT1 knock-out mammalian cells

Carlos P. Modenutti, M. Molinari, D. Hebert, 2023, bioRxiv.

The role of UDP-Glc:glycoprotein glucosyltransferase 1 in the maturation of an obligate substrate prosaposin

R. Kaufman, D. Hebert, G. Grabowski, 2010, The Journal of cell biology.