C. Jeffery

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Moonlighting Proteins in the Fuzzy Logic of Cellular Metabolism

Haipeng Liu, C. Jeffery, 2020, Molecules.

An Experimental Approach to Mapping the Binding Surfaces of Crystalline Proteins

Karen N. Allen, G. Petsko, D. Ringe, 1996 .

Molecular mechanisms for multitasking: recent crystal structures of moonlighting proteins.

Constance J Jeffery, C. Jeffery, 2004, Current opinion in structural biology.

Multifunctional proteins: examples of gene sharing

Constance J Jeffery, C. Jeffery, 2003, Annals of medicine.

Moonlighting proteins: complications and implications for proteomics research

Constance J. Jeffery, C. Jeffery, 2004 .

Proteins with neomorphic moonlighting functions in disease

Constance J Jeffery, C. Jeffery, 2011, IUBMB life.

Why study moonlighting proteins?

Constance J. Jeffery, C. Jeffery, 2015, Front. Genet..

Moonlighting proteins: old proteins learning new tricks.

Constance J Jeffery, C. Jeffery, 2003, Trends in genetics : TIG.

The CAFA challenge reports improved protein function prediction and new functional annotations for hundreds of genes through experimental screens

Jari Björne, Tapio Salakoski, Giorgio Valentini, 2019, Genome Biology.

Enzymes, pseudoenzymes, and moonlighting proteins: diversity of function in protein superfamilies

C. Jeffery, 2020, The FEBS journal.

The demise of catalysis, but new functions arise: pseudoenzymes as the phoenixes of the protein world.

C. Jeffery, 2019, Biochemical Society transactions.

Moonlighting proteins--an update.

Constance J Jeffery, C. Jeffery, 2009, Molecular bioSystems.

Moonlighting Functions of Heat Shock Protein 90

C. Jeffery, Chang Chen, 2019, Heat Shock Proteins.

Intracellular proteins moonlighting as bacterial adhesion factors

C. Jeffery, 2018, AIMS microbiology.

Crystal structure of rabbit phosphoglucose isomerase complexed with 5-phospho-D-arabinonate identifies the role of Glu357 in catalysis.

C. Jeffery, L. Salmon, R. Hardré, 2001, Biochemistry.

An enzyme in the test tube, and a transcription factor in the cell: Moonlighting proteins and cellular factors that affect their behavior

C. Jeffery, 2019, Protein science : a publication of the Protein Society.

Disruption of the monocarboxylate transporter-4-basigin interaction inhibits the hypoxic response, proliferation, and tumor progression

C. Jeffery, E. Bar, R. Spina, 2017, Scientific Reports.

Recombinant Expression Screening of P. aeruginosa Bacterial Inner Membrane Proteins

C. Jeffery, V. Madhavan, F. Bhatt, 2009, BMC biotechnology.

Multitalented actors inside and outside the cell: recent discoveries add to the number of moonlighting proteins.

C. Jeffery, 2019, Biochemical Society transactions.

The Escherichia coli aspartate receptor: sequence specificity of a transmembrane helix studied by hydrophobic-biased random mutagenesis.

D. Koshland, C. Jeffery, 1999, Protein engineering.

Expression, detergent solubilization, and purification of a membrane transporter, the MexB multidrug resistance protein.

C. Jeffery, F. Bhatt, 2010, Journal of visualized experiments : JoVE.

Protein moonlighting: what is it, and why is it important?

C. Jeffery, 2018, Philosophical Transactions of the Royal Society B: Biological Sciences.

Inhibition of type I and type II phosphomannose isomerases by the reaction intermediate analogue 5-phospho-D-arabinonohydroxamic acid supports a catalytic role for the metal cofactor.

C. Jeffery, J. H. Lee, L. Salmon, 2004, Biochemistry.

The reaction mechanism of type I phosphomannose isomerases: New information from inhibition and polarizable molecular mechanics studies

N. Gresh, B. de Courcy, J. Piquemal, 2011, Proteins.

An analysis of surface proteomics results reveals novel candidates for intracellular/surface moonlighting proteins in bacteria.

C. Jeffery, Wangfei Wang, 2016, Molecular bioSystems.

Physical Features of Intracellular Proteins that Moonlight on the Cell Surface

Vaishak Amblee, Constance J. Jeffery, C. Jeffery, 2015, PloS one.

Mass spectrometry and the search for moonlighting proteins.

Constance J Jeffery, C. Jeffery, 2005, Mass spectrometry reviews.

Disruption of the monocarboxylate transporter-4-basigin interaction inhibits the hypoxic response, proliferation, and tumor progression

C. Jeffery, E. Bar, R. Spina, 2017, Scientific Reports.

Protein species and moonlighting proteins: Very small changes in a protein's covalent structure can change its biochemical function.

C. Jeffery, 2016, Journal of proteomics.

The CAFA challenge reports improved protein function prediction and new functional annotations for hundreds of genes through experimental screens

Tapio Salakoski, Feng Zhang, Paolo Fontana, 2019, Genome Biology.

The expanding world of metabolic enzymes moonlighting as RNA binding proteins.

C. Jeffery, N. Curtis, 2021, Biochemical Society transactions.

Moonlighting Proteins – Nature's Swiss Army Knives

C. Jeffery, 2017, Science progress.

Utilizing the folate receptor for active targeting of cancer nanotherapeutics

G. Mansoori, C. Jeffery, Grant Zwicke, 2012, Nano reviews.

New Ideas on Protein Moonlighting

C. Jeffery, 2013 .

MoonProt 3.0: an update of the moonlighting proteins database

Shadi Zabad, Constance J. Jeffery, Chang Chen, 2020, Nucleic Acids Res..

An introduction to protein moonlighting.

Constance J Jeffery, C. Jeffery, 2014, Biochemical Society transactions.

Moonlighting proteins

Constance Jeffery, C. Jeffery, 2010, Genome Biology.

Crystal structure of rabbit phosphoglucose isomerase complexed with its substrateD-fructose 6-phosphate identifies the ring opening step in catalysis

C. Jeffery, J. H. Lee, V. Patel, 2002 .

Crystal structure of rabbit phosphoglucose isomerase complexed with its substrate D-fructose 6-phosphate.

J. H. Lee, C. Jeffery, C J Jeffery, 2001, Biochemistry.

Open Conformation of the Escherichia coli Periplasmic Murein Tripeptide Binding Protein, MppA, at High Resolution

C. Jeffery, V. Patel, F. Bhatt, 2018, Biology.

Crystal structure of phosphoglucose isomerase from Trypanosoma brucei complexed with glucose‐6‐phosphate at 1.6 Å resolution

C. Jeffery, D. Arsenieva, G. H. Mazock, 2009, Proteins.

The crystal structure of rabbit phosphoglucose isomerase complexed with 5-phospho-d-arabinonohydroxamic acid

C. Jeffery, D. Arsenieva, L. Salmon, 2002, Proceedings of the National Academy of Sciences of the United States of America.

The energetic cost of induced fit catalysis: Crystal structures of trypsinogen mutants with enhanced activity and inhibitor affinity

C. Jeffery, D Ringe, L Hedstrom, 2001, Protein science : a publication of the Protein Society.

Crystal structure of rabbit phosphoglucose isomerase, a glycolytic enzyme that moonlights as neuroleukin, autocrine motility factor, and differentiation mediator.

G. Petsko, D. Ringe, C. Jeffery, 2000, Biochemistry.

The role of residues outside the active site: structural basis for function of C191 mutants of Escherichia coli aspartate aminotransferase.

G. Petsko, D. Ringe, C. Jeffery, 2000, Protein engineering.

Three‐dimensional structural model of the serine receptor ligand‐binding domain

D E Koshland, D. Koshland, C. Jeffery, 1993, Protein science : a publication of the Protein Society.

Updating MoonProt From Home: An Online Student Research Project During the COVID-19 Pandemic

C. Jeffery, 2021, The Biophysicist.

MoonProt 2.0: an expansion and update of the moonlighting proteins database

Haipeng Liu, Chang Chen, Shadi Zabad, 2017, Nucleic Acids Res..

Vibrio cholerae hlyB is a member of the chemotaxis receptor gene family

D. Koshland, C. Jeffery, 1993, Protein science : a publication of the Protein Society.

Intracellular/surface moonlighting proteins that aid in the attachment of gut microbiota to the host

C. Jeffery, 2019, AIMS microbiology.

MoonProt: a database for proteins that are known to moonlight

Haipeng Liu, Chang Chen, Mathew Mani, 2013, Nucleic Acids Res..

Crystal structure of Saccharomyces cerevisiae cytosolic aspartate aminotransferase

G. Petsko, D. Ringe, C. Jeffery, 1998, Protein science : a publication of the Protein Society.

Engineering periplasmic ligand binding proteins as glucose nanosensors

Constance J. Jeffery, C. Jeffery, 2011, Nano reviews.

Expression, Solubilization, and Purification of Bacterial Membrane Proteins

C. Jeffery, 2016, Current protocols in protein science.

Keeping good friends close – The surface and secreted proteomes of a probiotic bacterium provide candidate proteins for intestinal attachment and communication with the host

C. Jeffery, 2017, Proteomics.

Molecular Chaperones and Cell Signalling: Moonlighting Proteins: Proteins with Multiple Functions

C. Jeffery, 2005 .

What is Protein Moonlighting and Why is it Important

Constance J. Jeffery, C. Jeffery, 2016 .

Conformational changes in phosphoglucose isomerase induced by ligand binding.

C. Jeffery, D. Arsenieva, 2002, Journal of molecular biology.

Faculty List

Michael T. Kirschenheiter, Jon A. Solworth, Ian A. Kash, 2018, International journal of urology.

Current successes and remaining challenges in protein function prediction

C. Jeffery, 2023, Frontiers Bioinform..

MSFP: undergraduate ‘collaborate-from-home’ research in macromolecular structure and function

C. Jeffery, 2023, Bioinformatics advances.

Promoting a more integrated approach to structure and function.

K. Dorgan, C. Jeffery, L. Pysh, 2021, Integrative and comparative biology.

The crystal structure of rabbit phosphoglucose isomerase complexed with D‐sorbitol‐6‐phosphate, an analog of the open chain form of D‐glucose‐6‐phosphate

C. Jeffery, Ji Hyun Lee, 2005, Protein science : a publication of the Protein Society.

An analysis of surface proteomics results reveals novel candidates for intracellular/surface moonlighting proteins in bacteria.

C. Jeffery, Wangfei Wang, 2016, Molecular bioSystems.

Moonlighting proteins--an update.

C. Jeffery, 2009, Molecular bioSystems.

Intracellular/Surface Moonlighting Proteins

C. Jeffery, Wangfei Wang, 2016 .

Moonlighting proteins.

C. Jeffery, 1999, Trends in biochemical sciences.

Moonlighting Proteins: Diverse Functions Found in Fungi

C. Jeffery, Nicole J. Curtis, Krupa J. Patel, 2023, Journal of fungi.

Molecular Chaperones and Cell Signalling: Moonlighting Proteins: Proteins with Multiple Functions

C. Jeffery, 2005 .

A single hydrophobic to hydrophobic substitution in the transmembrane domain impairs aspartate receptor function.

D. Koshland, C. Jeffery, 1994, Biochemistry.