A. Hamilton

Nathan T. Ross, William P. Katt, Andrew D. Hamilton, 2010, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.

Synthesis of a 2,3‘;6‘,3‘ ‘-Terpyridine Scaffold as an α-Helix Mimetic

Andrew D. Hamilton, A. Hamilton, Jessica M. Davis, 2005 .

Cyclopiperazines: A new approach to chiral macrocyclic receptors☆

A. Hamilton, Helen L. Larkins, 1986 .

Oligophenylenaminones as scaffolds for α-helix mimicry.

M. Adler, A. Hamilton, 2011, The Journal of organic chemistry.

Rigid macrocyclic triamides as anion receptors: anion-dependent binding stoichiometries and 1H chemical shift changes.

A. Hamilton, Kihang Choi, 2003, Journal of the American Chemical Society.

A Self‐Assembling, Hydrogen‐Bonded Helix

C. Vicent, A. Hamilton, Steven J. Geib, 1993 .

Supramolecular self-assembly based on directed hydrogen bonding

C. Vicent, A. Hamilton, Steven J. Geib, 1993 .

Synthesis and structure of chiral macrocycles containing 2,2'-bipyridine subunits.

A. Hamilton, A. D. Hamilton, J. Albert, 1996, Bioorganic & medicinal chemistry.

Macrocyclic anion receptors based on directed hydrogen bonding interactions

A. Hamilton, Kihang Choi, 2003 .

Nucleotide base recognition: a macrocyclic receptor for adenine employing hydrogen bonding and aromatic stacking interactions

A. Hamilton, S. Goswami, D. Engen, 1989 .

CALORIMETRIC INVESTIGATION OF GUANIDINIUM-CARBOXYLATE INTERACTIONS

A. Hamilton, B. Linton, 1999 .

1,3‐Dicyclohexylcarbodiimide–4‐Dimethylaminopyridine

A. Hamilton, J. Albert, 2001 .

Toward proteomimetics: terphenyl derivatives as structural and functional mimics of extended regions of an alpha-helix.

A. Hamilton, B. Orner, A D Hamilton, 2001, Journal of the American Chemical Society.

Efficacy, Pharmacokinetics, and Metabolism of Tetrahydroquinoline Inhibitors of Plasmodium falciparum Protein Farnesyltransferase

D. Chakrabarti, M. Gelb, F. Buckner, 2007, Antimicrobial Agents and Chemotherapy.

Molecular recognition: directed hydrogen bonding receptors for acylamino acid carboxylates

C. Vicent, A. Hamilton, E. Fan, 1992 .

Synthetic Studies on Molecular Recognition

A. Hamilton, 1991 .

Biosynthesis of porphyrins and related macrocycles. Part 13. Structure of the protoporphyrin isomer derived from coproporphyrinogen IV by the action of beef-liver coproporphyrinogenase: synthesis of protoporphyrin XIII.

A. Hamilton, A. Battersby, E. McDonald, 1980, Journal of the Chemical Society. Perkin transactions 1.

Synthesis of a doubly-bridged oxygen-carrier which shows reduced affinity for carbon monoxide

A. Hamilton, A. Battersby, 1980 .

Hydrogen-bonding control of molecular aggregation: Self-complementary subunits lead to rod-shaped structures in the solid state

Timothy C. Stoner, A. Hamilton, S. Geib, 1995 .

Molecular recognition and catalysis; acceleration of acyl transfer reactions by a hydrogen-bonding receptor

A. Hamilton, P. Tecilla, 1990 .

An organic hydrogel as a matrix for the growth of calcite crystals.

S. Weiner, L. Addadi, A. Hamilton, 2004, Organic & biomolecular chemistry.

Design of a synthetic foldamer that modifies the growth of calcite crystals.

A. Hamilton, L. Estroff, C. Incarvito, 2004, Journal of the American Chemical Society.

De novo protein surface design: use of cation-pi interactions to enhance binding between an alpha-helical peptide and a cationic molecule in 50 % aqueous solution.

E. Giralt, X. Salvatella, A. Hamilton, 2002, Angewandte Chemie.

Side chain elongation causes a change from enthalpy driven to entropy driven binding in the molecular recognition of tetraanionic peptides

M. Gairí, E. Giralt, X. Salvatella, 2000 .

Surface Recognition and Helix Stabilization of a Tetraaspartate Peptide by Shape and Electrostatic Complementarity of an Artificial Receptor

E. Giralt, X. Salvatella, T. Haack, 1999 .

Design, synthesis and evaluation of synthetic receptors for the recognition of aspartate pairs in an α-helical conformation☆

A. Hamilton, M. Peczuh, J. Albert, 1997 .

Protein Surface Recognition by Synthetic Receptors: A Route to Novel Submicromolar Inhibitors for α-Chymotrypsin

A. Hamilton, H. Park, Q. Lin, 1999 .

A tetraguanidinium ligand binds to the surface of the tetramerization domain of protein P53.

Ernest Giralt, Xavier Salvatella, Marc Martinell, 2004, Angewandte Chemie.

Synthetic non-peptide mimetics of alpha-helices.

Lun K Tsou, A. Hamilton, Andrew D Hamilton, 2007, Chemical Society reviews.

Terphenyl-based helical mimetics that disrupt the p53/HDM2 interaction.

S. Sebti, A. Hamilton, H. Yin, 2005, Angewandte Chemie.

Duplex DNA as a Self-Assembling Template for the Identification of Bidentate Protein-Binding Agents

A. Hamilton, D. M. Tagore, K. I. Sprinz, 2007 .

Noncovalent template-assisted mimicry of multiloop protein surfaces: assembling discontinuous and functional domains.

A. Hamilton, P. Ghosh, 2012, Journal of the American Chemical Society.

Combined solid/solution phase synthesis of large surface area scaffolds derived from aminomethyl-benzoates.

A. Hamilton, R. Jain, L. Tsou, 2009, Tetrahedron letters.

Inhibition of chymotrypsin by a self-assembled DNA quadruplex functionalized with cyclic peptide binding fragments.

A. Hamilton, Jianfeng Cai, Brooke A Rosenzweig, 2009, Chemistry.

Recognition of solvent exposed protein surfaces using anthracene derived receptors.

S. Fletcher, A. Hamilton, Andrew J. Wilson, 2007, Organic & biomolecular chemistry.

Protein recognition using synthetic surface-targeted agents

A. Hamilton, R. Jain, H. Park, 2004, Molecular Diversity.

Tetrabiphenylporphyrin-based receptors for protein surfaces show sub-nanomolar affinity and enhance unfolding.

A. Hamilton, T. Aya, 2003, Bioorganic & medicinal chemistry letters.

Modulation of protein–protein interactions by synthetic receptors: Design of molecules that disrupt serine protease–proteinaceous inhibitor interaction

A. Hamilton, H. Park, Q. Lin, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Protein surface recognition by synthetic receptors based on a tetraphenylporphyrin scaffold.

A. Hamilton, R. Jain, 2000, Organic letters.

Ion-mediated conformational switches

A. Hamilton, S. Thompson, P. Knipe, 2014, Chemical science.

The design of artificial receptors for complexation and controlled aggregation

A. Hamilton, S. Geib, Ji Yang, 1993, Philosophical Transactions of the Royal Society of London. Series A: Physical and Engineering Sciences.

Chiral recognition of tartaric acid derivatives by a synthetic receptor

A. Hamilton, J. Albert, F. García‐Tellado, 1991 .

Functional Synthetic Receptors

Thomas Schrader, Andrew D. Hamilton, A. Hamilton, 2005 .

Synthetic analogs of the ristocetin binding site: Neutral, multidentate receptors for carboxylate recognition

A. Hamilton, J. Albert, 1993 .

A Dual Channel Fluorescence Chemosensor for Anions Involving Intermolecular Excited State Proton Transfer.

A. Hamilton, Kihang Choi, 2001, Angewandte Chemie.

Molecular recognition and the design of solid state structures: protonation-induced conformational change and self-assembly of 2,6-diamidopyridinium phosphates

C. Vicent, A. Hamilton, Steven J. Geib, 1991 .

Design and application of an alpha-helix-mimetic scaffold based on an oligoamide-foldamer strategy: antagonism of the Bak BH3/Bcl-xL complex.

Jorge Becerril, A. Hamilton, H. Yin, 2003, Angewandte Chemie.

Pattern-based detection of different proteins using an array of fluorescent protein surface receptors.

Laura Baldini, Andrew J Wilson, A. Hamilton, 2004, Journal of the American Chemical Society.

Heterofunctionalized Cavitands by Macrocyclization of Sequence-Defined Foldamers

Joseph W. Meisel, C. Hu, A. Hamilton, 2019, Organic letters.

Synthetic alpha-helix mimetics as agonists and antagonists of islet amyloid polypeptide aggregation.

A. Miranker, A. Hamilton, L. Estroff, 2010, Angewandte Chemie.

Controlling curvature in a family of oligoamide alpha-helix mimetics.

A. Hamilton, C. Incarvito, Ishu Saraogi, 2008, Angewandte Chemie.

Protein surface recognition and proteomimetics: mimics of protein surface structure and function.

Steven Fletcher, S. Fletcher, A. Hamilton, 2005, Current opinion in chemical biology.

Novel Molecular Scaffolds: Formation of Helical Secondary Structure in a Family of Oligoanthranilamides

Y. Hamuro, A. Hamilton, Steven J. Geib, 1994 .

Design and Synthesis of Oligoamide-Based Double α-Helix Mimetics

A. Hamilton, Hai-Zhen Xu, C. Incarvito, 2013 .

Inhibiting angiogenesis and tumorigenesis by a synthetic molecule that blocks binding of both VEGF and PDGF to their receptors

D. Coppola, S. Sebti, A. Hamilton, 2004, Oncogene.

Blocking Angiogenesis and Tumorigenesis with GFA-116, a Synthetic Molecule that Inhibits Binding of Vascular Endothelial Growth Factor to its Receptor

D. Coppola, S. Brem, S. Sebti, 2004, Cancer Research.

Protein surface recognition by synthetic receptors

Y. Hamuro, A. Hamilton, H. Park, 1999 .

Conformational Selectivity in Molecular Recognition: The Influence of Artificial Receptors on the Cis-Trans Isomerization of Acylprolines

C. Vicent, A. Hamilton, F. García‐Tellado, 1991 .

Cryo-Tem, X-Ray Diffraction and Modeling of an Organic Hydrogel

A. Hamilton, L. Estroff, 2006 .

Low molecular weight organogelators for water.

A. Hamilton, Guijun Wang, 2003, Chemical communications.

Design and synthesis of multiple-loop receptors based on a calix〚4〛arene scaffold for protein surface recognition

A. Hamilton, Q. Lin, 2002 .

A Calixarene with Four Peptide Loops: An Antibody Mimic for Recognition of Protein Surfaces

Andrew D. Hamilton, Mercedes Crego Calama, Yoshitomo Hamuro, 1997 .

Molecular Recognition and Catalysis. Acceleration of Phosphodiester Cleavage by a Simple Hydrogen-Bonding Receptor

A. Hamilton, V. Jubian, R. P. Dixon, 1992 .

Nucleotide base recognition: Ditopic binding of guanine to a macrocyclic receptor containing naphthyridine and naphthalene units

N. Pant, A. Hamilton, 1988 .

Molecular Recognition in Biomimetic Receptors

A. Hamilton, S. Thompson, P. Knipe, 2016 .

Protein surface recognition by synthetic agents: Design and structural requirements of a family of artificial receptors that bind to cytochrome C

Y. Hamuro, A. Hamilton, H. Park, 1998, Biopolymers.

Molecular recognition: bis-acylguanidiniums provide a simple family of receptors for phosphodiesters

A. Hamilton, Steven J. Geib, R. P. Dixon, 1992 .

Molecular recognition: Synthetic approaches to artificial receptors

A. Hamilton, E. Fan, 1999 .

Nucleotide base recognition: synthesis of artificial receptors containing two distinct binding regions for the complexation of bis-thymine derivatives

A. Hamilton, D. Little, 1990 .

New Synthetic Receptors for Complexation and Catalysis

A. Hamilton, 1992 .

Towards artificial antibodies: Protein surface recognition by synthetic receptors

A. Hamilton, R. Jain, Q. Lin, 2002 .

Complexation control of pericyclic reactions : supramolecular effects on the intramolecular diels : alder reaction

A. Hamilton, S. Hirst, 1991 .

Directed denaturation: room temperature and stoichiometric unfolding of cytochrome C by a metalloporphyrin dimer.

A. Hamilton, Andrew J. Wilson, R. Jain, 2003, Journal of the American Chemical Society.

Altered binding of a multimeric protein by changing the self-assembling properties of its substrate.

Nathan T. Ross, M. Adler, A. Hamilton, 2010, Journal of the American Chemical Society.

Binuclear complexes of a covalently linked porphyrin-bipyridine ligand

A. Hamilton, A. Bocarsly, H. Rubin, 1984 .

The design of organic gelators: Solution and solid state properties of a family of bis-ureas

A. Hamilton, A. Carr, Steven J. Geib, 1998 .

pH-dependent conformational switching in 2,6-benzamidodiphenylacetylenes.

A. Hamilton, Hannah Lingard, I. M. Jones, 2011, Angewandte Chemie.

Amphiphilic oligoamide α-helix peptidomimetics inhibit islet amyloid polypeptide aggregation

A. Miranker, A. Hamilton, Sunil Kumar, 2015 .

Tetracyanoresorcin[4]arene selectively recognises trimethyllysine and inhibits its enzyme-catalysed demethylation

A. Hamilton, A. Kawamura, C. Thinnes, 2016 .

Recent Advances in the Development of Aryl-Based Foldamers

A. Hamilton, Ishu Saraogi, 2009 .

Acid-mediated topological control in a functionalized foldamer.

A. Hamilton, S. Thompson, P. Knipe, 2016, Chemical communications.

alpha-Helix mimetics as inhibitors of protein-protein interactions.

Andrew D. Hamilton, A. Hamilton, Ishu Saraogi, 2008, Biochemical Society transactions.

Islet amyloid-induced cell death and bilayer integrity loss share a molecular origin targetable with oligopyridylamide-based α-helical mimetics.

A. Miranker, A. Hamilton, E. Rhoades, 2015, Chemistry & biology.

Exploring novel strategies for AIDS protozoal pathogens: α-helix mimetics targeting a key allosteric protein-protein interaction in C. hominis TS-DHFR.

K. Anderson, A. Hamilton, Johanna M. Rodriguez, 2013, MedChemComm.

Hybrid Diphenylalkyne-Dipeptide Oligomers Induce Multistrand β-Sheet Formation.

A. Hamilton, S. Thompson, P. Knipe, 2015, Chemistry.

New supramolecular arrays based on interactions between carboxylate and urea groups: solid-state and solution behavior

Y. Hamuro, A. Hamilton, Steven J. Geib, 1998 .

Molecular recognition and catalysis: Incorporation of an "oxyanion hole" into a synthetic receptor

C. Vicent, A. Hamilton, E. Fan, 1997 .

Transition-state stabilization and molecular recognition: acceleration of phosphoryl-transfer reactions by an artificial receptor

A. Hamilton, P. Tecilla, Suk-Kyu Chang, 1990 .

Foldamer-Mediated Structural Rearrangement Attenuates Aβ Oligomerization and Cytotoxicity.

A. Hamilton, Sunil Kumar, Anja Henning-Knechtel, 2017, Journal of the American Chemical Society.

Structure and Function of Benzoylurea‐Derived α‐Helix Mimetics Targeting the Bcl‐xL/Bak Binding Interface

Nathan T. Ross, William P. Katt, A. Hamilton, 2009, ChemMedChem.

Synthetic hydrogen bonding receptors as models of transacylase enzymes

A. Hamilton, P. Tecilla, V. Jubian, 1995 .

Isophthalic acid-derived organogelators

A. Hamilton, V. Potluri, 2002 .

Synthesis of tetrameric and hexameric cyclo-porphyrins

A. Hamilton, G. Dubowchik, 1987 .

Towards a synthetic model of the structure of the photosynthetic reaction centre

A. Hamilton, G. Dubowchik, 1986 .

X-ray crystal structures of bridged porphyrins

G. Sheldrick, A. Hamilton, A. Battersby, 1980 .

Novel 7-(dimethylamino)fluorene-based fluorescent probes and their binding to human serum albumin.

A. Hamilton, K. Park, J. Park, 2009, Organic & biomolecular chemistry.

Hydrogen Bonding Control of Molecular Self-Assembly: Aggregation Behavior of Acylaminopyridine–Carboxylic Acid Derivatives in Solution and the Solid State

Y. Hamuro, A. Hamilton, A. Carr, 2000 .

Self-assembling structures based on hydrogen bonding subunits

A. Hamilton, A. Zafar, 1999 .

Oxygenated hydrocarbon ionic surfactants exhibit CO2 solubility.

A. Hamilton, E. Beckman, J. Johnson, 2005, Journal of the American Chemical Society.

Unpicking the determinants of amide NHO[double bond, length as m-dash]C hydrogen bond strength with diphenylacetylene molecular balances.

A. Hamilton, S. Thompson, I. M. Jones, 2017, Organic & biomolecular chemistry.

Mimicry of a β-Hairpin Turn by a Nonpeptidic Laterally Flexible Foldamer.

Joseph W. Meisel, C. Hu, A. Hamilton, 2018, Organic letters.

A Lewis acid-mediated conformational switch.

A. Hamilton, Hannah Lingard, S. Thompson, 2014, Organic & biomolecular chemistry.

Effective Gelation of Water Using a Series of Bis‐urea Dicarboxylic Acids

A. Hamilton, L. Estroff, 2000 .

The Design of Organic Gelators: Solution and Solid State Properties of a Family of Bis-Ureas.

A. Hamilton, A. Carr, Steven J. Geib, 1998 .

Characterization of an Organic Hydrogel: A Cryo‐Transmission Electron Microscopy and X‐ray Diffraction Study

S. Weiner, L. Addadi, A. Hamilton, 2003 .

Design of growth factor antagonists with antiangiogenic and antitumor properties

S. Sebti, A. Hamilton, 2000, Oncogene.

A Versatile One-Pot Synthesis of 1,3-Substituted Guanidines from Carbamoyl Isothiocyanates.

A. Hamilton, B. Orner, A. Carr, 2000 .

Aryl-linked imidazolidin-2-ones as non-peptidic β-strand mimetics.

A. Hamilton, S. Thompson, Charlotte L. Sutherell, 2012, Chemical communications.

Intra- and Intermolecular Hydrogen Bonding Control of Supramolecular Structure

Y. Hamuro, A. Hamilton, Steven J. Geib, 1994 .

The design of organic gelators based on a family of bis-ureas

A. Hamilton, K. Sada, Rosa E. Meléndez, 1999 .

Molecular recognition: Porphyrin containing receptors as analogs of barbiturate induced cytochrome P450

A. Hamilton, G. Slobodkin, E. Fan, 1992 .

Stabilization of helical domains in short peptides using hydrophobic interactions.

A. Hamilton, A. D. Hamilton, J. Albert, 1995, Biochemistry.

Fiber formation in water by a mono-urea dicarboxylic acid.

A. Hamilton, L. Estroff, Jessica S Huang, 2003, Chemical communications.

Teaching an old scaffold new recognition tricks: oligopyrrolamide antagonists of IAPP aggregation.

A. Hamilton, Sunil Kumar, M. Vogel, 2018, Organic & biomolecular chemistry.

Structural basis for binding and selectivity of antimalarial and anticancer ethylenediamine inhibitors to protein farnesyltransferase.

Steven Fletcher, M. Gelb, L. Beese, 2009, Chemistry & biology.

Potent, Plasmodium-selective farnesyltransferase inhibitors that arrest the growth of malaria parasites: structure-activity relationships of ethylenediamine-analogue scaffolds and homology model validation.

William P. Katt, D. Chakrabarti, M. Gelb, 2008, Journal of medicinal chemistry.

Protein farnesyltransferase: Flexible docking studies on inhibitors using computational modeling

Andrew D. Hamilton, Wayne C. Guida, Justin W. Crotty, 2006, J. Comput. Aided Mol. Des..

Design and synthesis of peptidomimetic protein farnesyltransferase inhibitors as anti-Trypanosoma brucei agents.

S. Croft, M. Gelb, F. Buckner, 2004, Journal of medicinal chemistry.

Peptidomimetic inhibitors of protein farnesyltransferase show potent antimalarial activity.

S. Croft, M. Gelb, S. Sebti, 2001, Bioorganic & medicinal chemistry letters.

Peptidomimetic-based inhibitors of farnesyltransferase

David A. Knowles, S. Sebti, S. Rosenberg, 2001 .

Protein Prenylation in Trypanosomatids

K. Stuart, M. Gelb, F. Buckner, 2001 .

A class of sterol 14-demethylase inhibitors as anti-Trypanosoma cruzi agents

M. Gelb, F. Buckner, S. Sebti, 2003, Proceedings of the National Academy of Sciences of the United States of America.

p53 α-Helix mimetics antagonize p53/MDM2 interaction and activate p53

Jiandong Chen, S. Sebti, Lihong Chen, 2005, Molecular Cancer Therapeutics.

Constrained analogs of methionine: asymmetric synthesis of χ-angle restricted methionine derivatives through [3.1.0]-γ-lactone cyclopropane ring opening

A. Hamilton, Kee-In Lee, Chang‐Sun Lee, 2001 .

Ferrochelatase: isolation and purification via affinity chromatography.

A. Hamilton, D. Dolphin, R. Poulson, 1980, Biochemical and biophysical research communications.

Constrained Analogues of Methionine: Asymmetric Synthesis of χ-Angle Restricted Methionine Derivatives Through [3.1.0]-γ-Lactone Cyclopropane Ring Opening.

A. Hamilton, Kee-In Lee, Chang‐Sun Lee, 2001 .

The Geranylgeranyltransferase-I Inhibitor GGTI-298 Arrests Human Tumor Cells in G0/G1 and Induces p21WAF1/CIP1/SDI1 in a p53-independent Manner*

S. Sebti, A. Hamilton, Jiazhi Sun, 1997, The Journal of Biological Chemistry.

Optimization of pyrimidinyl- and triazinyl-amines as non-nucleoside inhibitors of HIV-1 reverse transcriptase.

William L Jorgensen, Robert A. Domaoal, Christopher M. Bailey, 2006, Bioorganic & medicinal chemistry letters.

Optimization of diarylamines as non-nucleoside inhibitors of HIV-1 reverse transcriptase.

William L Jorgensen, Christopher M. Bailey, W. L. Jorgensen, 2006, Bioorganic & medicinal chemistry letters.

In vivo antiviral efficacy of prenylation inhibitors against hepatitis delta virus.

Ping Liu, M. Kay, J. Glenn, 2003, The Journal of clinical investigation.

A Novel Class of meso-Tetrakis-Porphyrin Derivatives Exhibits Potent Activities against Hepatitis C Virus Genotype 1b Replicons In Vitro

B. Lindenbach, A. Hamilton, E. Gullen, 2009, Antimicrobial Agents and Chemotherapy.

Chapter 6 – Geranylgeranyltransferase-1 Inhibitors

S. Sebti, A. Hamilton, N. Berndt, 2011 .

Molecular recognition: Cyclobutane thymine diners as rigid two-site receptors

A. Hamilton, S. Hirst, 1990 .

Akt/Protein Kinase B Signaling Inhibitor-2, a Selective Small Molecule Inhibitor of Akt Signaling with Antitumor Activity in Cancer Cells Overexpressing Akt

Andrew D. Hamilton, Meenhard Herlyn, S. Nicosia, 2004, Cancer Research.

Hydrogen-bonded synthetic mimics of protein secondary structure as disruptors of protein-protein interactions.

M. Adler, A. Hamilton, A. Jamieson, 2010, Current topics in microbiology and immunology.

Farnesyltransferase inhibitor R115777 (Zarnestra, Tipifarnib) synergizes with paclitaxel to induce apoptosis and mitotic arrest and to inhibit tumor growth of multiple myeloma cells.

C. Beam, W. Dalton, S. Sebti, 2005, Blood.

Geranylgeranyltransferase I inhibitor GGTI-2154 induces breast carcinoma apoptosis and tumor regression in H-Ras transgenic mice.

D. Coppola, S. Sebti, A. Hamilton, 2003, Cancer research.

Inhibitors of protein farnesyltransferase as novel anticancer agents.

S. Sebti, A. Hamilton, M. Blaskovich, 2002, Current Topics in Medicinal Chemistry.

Targeting protein prenylation for cancer therapy

S. Sebti, A. Hamilton, N. Berndt, 2011, Nature Reviews Cancer.

Terephthalamide derivatives as mimetics of the helical region of Bak peptide target Bcl-xL protein.

A. Hamilton, H. Yin, 2004, Bioorganic & medicinal chemistry letters.

General aspects of protein prenylation The importance of FT and GGT 1 for normal physiology and tumorigenesis : lessons from knockout mice

S. Sebti, A. Hamilton, N. Berndt, 2014 .

Phosphotyrosyl Peptides Block Stat3-mediated DNA Binding Activity, Gene Regulation, and Cell Transformation*

J. Turkson, R. Jove, A. Hamilton, 2001, The Journal of Biological Chemistry.

Allosteric activation dictates PRC2 activity independent of its recruitment to chromatin

D. Reinberg, A. Hamilton, S. Kaneko, 2017, bioRxiv.

Helix mimetics as inhibitors of the interaction of the estrogen receptor with coactivator peptides.

A. Hamilton, J. Becerril, 2007, Angewandte Chemie.

Inhibitor GGTI-298 through a Transforming Growth Factor b- and Sp1-Responsive Element: Involvement of the Small GTPase RhoA

S. Sebti, A. Hamilton, Y. Qian, 1998 .

Examination of the effect of the annealing cation on higher order structures containing guanine or isoguanine repeats.

Sarah E. Pierce, Junmei Wang, J. Brodbelt, 2009, Chemistry.

C. Der, S. Sebti, M. Kinch, 1997, The Journal of Biological Chemistry.

Farnesyltransferase Inhibitors Potentiate the Antitumor Effect of Radiation on a Human Tumor Xenograft Expressing Activated HRAS1

R. Muschel, D. Kusewitt, S. Sebti, 2000, Radiation research.

Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts

S. Sebti, A. Hamilton, Jiazhi Sun, 1998, Oncogene.

Potent inhibition of human tumor p21ras farnesyltransferase by A1A2-lacking p21ras CA1A2X peptidomimetics.

S. Sebti, A. Hamilton, Y. Qian, 1993, The Journal of biological chemistry.

Tyrosine phosphorylation of focal adhesion kinase by PDGF is dependent on Ras in human hepatic stellate cells

S. Sebti, A. Hamilton, G. Bellomo, 2000, Hepatology.

Protein geranylgeranylation, not farnesylation, is required for the G1 to S phase transition in mouse fibroblasts.

S. Sebti, A. Hamilton, T. Mcguire, 1996, Oncogene.

The BH3 α-Helical Mimic BH3-M6 Disrupts Bcl-XL, Bcl-2, and MCL-1 Protein-Protein Interactions with Bax, Bak, Bad, or Bim and Induces Apoptosis in a Bax- and Bim-dependent Manner*

S. Sebti, Aslamuzzaman Kazi, A. Hamilton, 2010, The Journal of Biological Chemistry.

Novel peptidomimetic inhibitors of signal transducer and activator of transcription 3 dimerization and biological activity.

J. Turkson, R. Jove, Meijuan Huang, 2004, Molecular cancer therapeutics.

Inhibition of Protein-Protein Interactions by Peptide Mimics

Pauline N. Wyrembak, A. Hamilton, J. Becerril, 2010 .

Inhibition of Ras and related guanosine triphosphate-dependent proteins as a therapeutic strategy for blocking malignant glioma growth: II--preclinical studies in a nude mouse model.

I. Pollack, M. Bredel, S. Sebti, 1999, Neurosurgery.

RhoA Prenylation Is Required for Promotion of Cell Growth and Transformation and Cytoskeleton Organization but Not for Induction of Serum Response Element Transcription*

S. Sebti, G. Favre, A. Hamilton, 2000, The Journal of Biological Chemistry.

Inhibition of the HIF1α-p300 interaction by quinone- and indandione-mediated ejection of structural Zn(II).

Kristina M. Cook, J. Mcmahon, A. Hamilton, 2015, European journal of medicinal chemistry.

Use of proximity ligation to screen for inhibitors of interactions between vascular endothelial growth factor A and its receptors.

U. Landegren, S. Gústafsdóttir, S. Sebti, 2008, Clinical chemistry.

Platelet-derived Growth Factor Receptor Tyrosine Phosphorylation Requires Protein Geranylgeranylation but not Farnesylation*

S. Sebti, A. Hamilton, T. Mcguire, 1996, The Journal of Biological Chemistry.

Geranylgeranyltransferase I Inhibitors Target RalB To Inhibit Anchorage-Dependent Growth and Induce Apoptosis and RalA To Inhibit Anchorage-Independent Growth

C. Der, S. Sebti, A. Hamilton, 2007, Molecular and Cellular Biology.

Label-free immunodetection with CMOS-compatible semiconducting nanowires

Mark A. Reed, Andrew D. Hamilton, David A. Routenberg, 2007, Nature.

Ras CAAX Peptidomimetic FTI-277 Selectively Blocks Oncogenic Ras Signaling by Inducing Cytoplasmic Accumulation of Inactive Ras-Raf Complexes (*)

C. Der, S. Sebti, A. Hamilton, 1995, The Journal of Biological Chemistry.

Disruption of Oncogenic K-Ras4B Processing and Signaling by a Potent Geranylgeranyltransferase I Inhibitor(*)

S. Sebti, A. Hamilton, Y. Qian, 1995, The Journal of Biological Chemistry.

XTT formazan widely used to detect cell viability inhibits HIV type 1 infection in vitro by targeting gp41.

A. Debnath, A. Hamilton, Shibo Jiang, 2002, AIDS research and human retroviruses.

Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines

S. Sebti, A. Hamilton, Y. Qian, 1997, Oncogene.

GGTI-298 induces G0-G1 block and apoptosis whereas FTI-277 causes G2-M enrichment in A549 cells.

S. Sebti, G. Favre, A. Hamilton, 1997, Cancer research.

Farnesyltransferase and Geranylgeranyltransferase I Inhibitors as Novel Agents for Cancer and Cardiovascular Diseases

S. Sebti, A. Hamilton, 2001 .

TGF-beta1 stimulation of fibronectin transcription in cultured human lung fibroblasts requires active geranylgeranyl transferase I, phosphatidylcholine-specific phospholipase C, protein kinase C-delta, and p38, but not erk1/erk2.

S. Sebti, A. Hamilton, U. Kucich, 2000, Archives of biochemistry and biophysics.

Effect of farnesyltransferase inhibitor FTI-276 on established lung adenomas from A/J mice induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.

M. You, S. Sebti, A. Hamilton, 2000, Carcinogenesis.

Blocking HIV-1 entry by a gp120 surface binding inhibitor.

A. Hamilton, Chin-Ho Chen, L. Tsou, 2012, Bioorganic & medicinal chemistry letters.

p53 alpha-Helix mimetics antagonize p53/MDM2 interaction and activate p53.

Jiandong Chen, S. Sebti, Lihong Chen, 2005, Molecular cancer therapeutics.

Inhibition of Protein Geranylgeranylation and RhoA/RhoA Kinase Pathway Induces Apoptosis in Human Endothelial Cells*

Xianwu Li, S. Sebti, A. Hamilton, 2002, The Journal of Biological Chemistry.

Combination of Farnesyltransferase and Akt Inhibitors Is Synergistic in Breast Cancer Cells and Causes Significant Breast Tumor Regression in ErbB2 Transgenic Mice

D. Coppola, J. Cheng, S. Sebti, 2011, Clinical Cancer Research.

Cancer Therapy : Preclinical Combination of Farnesyltransferase and Akt Inhibitors Is Synergistic in Breast Cancer Cells and Causes Significant Breast Tumor Regression in ErbB 2 Transgenic Mice

D. Coppola, J. Cheng, S. Sebti, 2011 .

Isoform selective inhibition of STAT1 or STAT3 homo-dimerization via peptidomimetic probes: structural recognition of STAT SH2 domains.

William P. Katt, J. Turkson, R. Jove, 2007, Bioorganic & medicinal chemistry letters.

Surface Binding Inhibitors of the SCF–KIT Protein–Protein Interaction

D. Margulies, I. Lax, J. Schlessinger, 2009, Chembiochem : a European journal of chemical biology.

Farnesylated RhoB Prevents Cell Cycle Arrest and Actin Cytoskeleton Disruption Caused by the Geranylgeranyltransferase I Inhibitor GGTI-298

S. Sebti, G. Favre, A. Hamilton, 2002, Cell cycle.

Protein surface recognition by porphyrin-based receptors

A. Hamilton, R. Jain, L. Tsou, 2004 .

Design of a protein surface antagonist based on alpha-helix mimicry: inhibition of gp41 assembly and viral fusion.

Shibo Jiang, Asim K Debnath, A. Debnath, 2002, Angewandte Chemie.

Structurally simple inhibitors of lanosterol 14alpha-demethylase are efficacious in a rodent model of acute Chagas disease.

M. Gelb, F. Buckner, C. Verlinde, 2009, Journal of medicinal chemistry.

Rational design of Ras prenyltransferase inhibitors as potential anticancer drugs.

S. Sebti, A. Hamilton, 1996, Biochemical Society transactions.

In vitro and in vivo antimalarial activity of peptidomimetic protein farnesyltransferase inhibitors with improved membrane permeability.

D. Chakrabarti, S. Croft, M. Gelb, 2004, Bioorganic & medicinal chemistry.

Sub-stoichiometric inhibition of IAPP aggregation: a peptidomimetic approach to anti-amyloid agents

A. Hamilton, L. Gremer, W. Hoyer, 2020, RSC chemical biology.

Farnesyltransferase inhibitors as anticancer agents: current status.

S. Sebti, A. Hamilton, K. Zhu, 2003, Current opinion in investigational drugs.

Selective inhibition of type-I geranylgeranyltransferase in vitro and in whole cells by CAAL peptidomimetics.

A. Vasudevan, S. Sebti, A. Hamilton, 1998, Bioorganic & medicinal chemistry.

Differential effects of invasion by and phagocytosis of Salmonella typhimurium on apoptosis in human macrophages: potential role of Rho–GTPases and Akt

S. Sebti, A. Hamilton, E. Särndahl, 2003, Journal of leukocyte biology.

Inhibition of geranylgeranyltransferase I decreases generation of vascular reactive oxygen species and increases vascular nitric oxide production.

S. Sebti, A. Hamilton, B. Zuckerbraun, 2005, The Journal of surgical research.

Development of a Potent Bcl-xL Antagonist Based on α-Helix Mimicry

Andrew D. Hamilton, A. Hamilton, B. Orner, 2002 .

Amphiphilic α-helix mimetics based on a benzoylurea scaffold.

A. Hamilton, S. Thompson, 2012, Organic & biomolecular chemistry.

Protein-protein interaction inhibitors: small molecules from screening techniques.

Steven Fletcher, S. Fletcher, A. Hamilton, 2007, Current topics in medicinal chemistry.

Targeting Protein–Protein Interactions: Suppression of Stat3 Dimerization with Rationally Designed Small‐Molecule, Nonpeptidic SH2 Domain Binders

William P. Katt, J. Turkson, S. Sebti, 2008, Chembiochem : a European journal of chemical biology.

Non-peptidic substrate-mimetic inhibitors of Akt as potential anti-cancer agents.

J. Cheng, S. Sebti, A. Hamilton, 2009, Bioorganic & medicinal chemistry.

Signaling events required for transforming growth factor-beta stimulation of connective tissue growth factor expression by cultured human lung fibroblasts.

S. Sebti, A. Hamilton, U. Kucich, 2001, Archives of biochemistry and biophysics.

Rationally designed helical peptidomimetics disrupt α-synuclein fibrillation.

A. Hamilton, Jinghui Luo, S. Thompson, 2022, Chemical communications.

Peptidomimetic-Based Vesicles Inhibit Amyloid-β Fibrillation and Attenuate Cytotoxicity.

A. Hamilton, M. Magzoub, D. Maity, 2021, Journal of the American Chemical Society.

Novel inhibitors of a Grb2 SH3C domain interaction identified by a virtual screen.

P. Simister, S. Feller, A. Hamilton, 2013, Bioorganic & medicinal chemistry.

SH3 Domains as Drug Targets

A. Hamilton, S. Thompson, James W. Luccarelli, 2013 .

Molecular Recognition in the Solid State: Hydrogen-Bonding Control of Molecular Aggregation

C. Vicent, A. Hamilton, Steven J. Geib, 1994 .

Designed Cell-Penetrating Peptide Inhibitors of Amyloid-beta Aggregation and Cytotoxicity

Serdal Kirmizialtin, A. Hamilton, G. Esposito, 2020 .

H-Ras Transgenic Mice Breast Carcinoma Apoptosis and Tumor Regression in Geranylgeranyltransferase I Inhibitor GGTI-2154 Induces

D. Coppola, S. Sebti, A. Hamilton, 2003 .

Hydrogen bonding in biological and artificial molecular recognition

A. Hamilton, 1990 .

Inhibition of type I collagen gene expression in normal and systemic sclerosis fibroblasts by a specific inhibitor of geranylgeranyl transferase I.

S. Jimenez, S. Sebti, A. Hamilton, 2000, Arthritis and rheumatism.

1-Phenyl-1H-pyrrole-2,5-dicarboxylic acid derivatives as versatile hydrogen-bonding motifs for the formation of one-, two- and three-dimensional networks in the solid state

A. Hamilton, Steven J. Geib, Q. Lin, 1998 .

Farnesyltransferase inhibitors: Anti-Ras drugs for cancer treatment

C. Der, S. Sebti, A. Hamilton, 1996 .

Farnesyltransferase inhibitor R 115777 ( Zarnestra , Tipifarnib ) synergizes with paclitaxel to induce apoptosis and mitotic arrest and to inhibit tumor growth of multiple myeloma cells

C. Beam, W. Dalton, S. Sebti, 2005 .

Excited-state photophysics of donor-appended cobalt(II) porphyrins from picosecond transient absorption spectroscopy

D. Melamed, A. Hamilton, T. Spiro, 1993 .

Ultrafast energy transfer within pyropheophorbide-a tethered to self-assembling DNA quadruplex.

A. Hamilton, D. Niedzwiedzki, H. Frank, 2010, Chemical Communications.

Model studies on the active site of cytochrome P-450 : an FeII–porphyrin carrying a strapped thiolate ligand

A. Hamilton, A. Battersby, W. Howson, 1982 .

Synthesis and biological evaluation of a 5-6-5 imidazole-phenyl-thiazole based alpha-helix mimetic.

Nathan T. Ross, William P. Katt, A. Hamilton, 2009, Organic letters.

Design and structural requirements of potent peptidomimetic inhibitors of p21ras farnesyltransferase.

S. Sebti, A. Hamilton, Y. Qian, 1994, The Journal of biological chemistry.

Foldamer‐based Molecular Recognition

A. Hamilton, J. Becerril, Johanna M. Rodriguez, 2007 .

Single-molecule nanopore dielectrophoretic trapping of α-Synuclein with lipid membranes

A. Hamilton, Jinming Wu, Jinghui Luo, 2022, bioRxiv.

Design of artificial receptors for biochemically interesting substrates

A. Hamilton, S. Goswami, Suk-Kyu Chang, 1989 .

Model systems — Artificial models of protein function

A. Hamilton, A. Kirby, 2001 .

Hydrogen Bond Controlled Aggregation of Guanidinium-Carboxylate Derivatives in the Solid State.

A. Hamilton, Steven J. Geib, A. Zafar, 2010 .

Protein Surface Recognition

M. Gairí, E. Giralt, X. Salvatella, 1999 .

Expedient route to functionalized and water soluble 5-6-5 imidazole-phenyl-thiazole based α-helix mimetics

A. Hamilton, C. Cummings, 2013 .

A peptidomimetic approach to targeting pre-amyloidogenic states in type II diabetes.

A. Miranker, A. Hamilton, M. Magzoub, 2009, Chemistry & biology.

Benzoylurea oligomers: synthetic foldamers that mimic extended alpha helices.

A. Hamilton, Andrew D Hamilton, Johanna M. Rodriguez, 2007, Angewandte Chemie.

CAAX peptidomimetic FTI-244 decreases platelet-derived growth factor receptor tyrosine phosphorylation levels and inhibits stimulation of phosphatidylinositol 3-kinase but not mitogen-activated protein kinase.

S. Corey, A. Hamilton, T. Mcguire, 1995, Biochemical and biophysical research communications.

Potent, highly selective, and non-thiol inhibitors of protein geranylgeranyltransferase-I.

A. Vasudevan, S. Sebti, A. Hamilton, 1999, Journal of medicinal chemistry.

Fluorescence sensing of anions

A. Hamilton, Kihang Choi, 2003 .

Self-assembly of bivalent protein-binding agents based on oligonucleotide-linked organic fragments.

A. Hamilton, D. M. Tagore, K. I. Sprinz, 2005, Bioorganic & medicinal chemistry letters.

Molecular design and bioorganic catalysis

C. Wilcox, A. Hamilton, 1996 .

Specific inhibition of flavin catalyses by a “molecular hinge”

A. Hamilton, S. Shinkai, H. S. Rosenzweig, 1989 .

ON THE FORMATION OF BILE PIGMENTS FROM HEME PROTEINS

A. Hamilton, D. Dolphin, 1977 .

Enaminone-based mimics of extended and hydrophilic α-helices.

M. Adler, A. Hamilton, Richard T W Scott, 2012, Chemistry.

Double-sided α-helix mimetics

M. Adler, A. Hamilton, S. Thompson, 2012 .

Inhibitors of ras farnesyltransferase as novel antitumor agents

A. Hamilton, S. Sebti, 1995 .

Denaturation and accelerated proteolysis of sizeable heme proteins by synthetic metalloporphyrins

S. Fletcher, A. Hamilton, 2007 .

Catalytic unfolding and proteolysis of cytochrome C induced by synthetic binding agents.

A. Hamilton, Andrew J. Wilson, K. Groves, 2004, Journal of the American Chemical Society.

Effect of farnesyltransferase inhibitor FTI-276 on established lung adenomas from A/J mice induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone function in cell pathways by cycling

S. Sebti, A. Hamilton, R. Lubet, 1999 .

Differential effects of Stat3 inhibition in sparse vs confluent normal and breast cancer cells.

J. Turkson, R. Jove, A. Hamilton, 2006, Cancer letters.

Facile and selective aerobic oxidation of arylalkanes to aryl ketones using cesium carbonate

A. Hamilton, L. Tsou, K. Park, 2006 .

Protein – Protein Interactions Terphenyl-Based Helical Mimetics That Disrupt the p 53 / HDM 2 Interaction * *

S. Sebti, A. Hamilton, H. Yin, 2007 .

STAT3 inhibitor having anti-cancer activity and methods (US)

J. Turkson, R. Jove, S. Sebti, 2020 .

S. Sebti, A. Hamilton, U. Kucich, 2000, Archives of biochemistry and biophysics.

alpha-Helix mimetics as inhibitors of protein-protein interactions.

A. Hamilton, Ishu Saraogi, 2008, Biochemical Society transactions.

Structure-based design and synthesis of potent, ethylenediamine-based, mammalian farnesyltransferase inhibitors as anticancer agents.

William P. Katt, M. Gelb, L. Beese, 2010, Journal of medicinal chemistry.

Supramolecular control of structure and reactivity

A. Hamilton, 1996 .

Burkitt lymphoma Daudi cells contain two distinct farnesyltransferases with different divalent cation requirements.

S. Sebti, A. Hamilton, Y. Qian, 1995, Biochemistry.

Recent developments in the identification of chemotherapeutics for Chagas disease.

A. Hamilton, J. Lockman, 2005, Current medicinal chemistry.

William P. Katt, D. Chakrabarti, M. Gelb, 2008, Journal of medicinal chemistry.