J. Toguchida

J. Toguchida, T. Aoyama, S. Nagayama, 2004, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Induced pluripotent stem cells from patients with human fibrodysplasia ossificans progressiva show increased mineralization and cartilage formation

B. Conklin, E. Hsiao, S. Yamanaka, 2013, Orphanet Journal of Rare Diseases.

Expression of the cadherin-11 gene is a discriminative factor between articular and growth plate chondrocytes.

J. Toguchida, T. Aoyama, T. Nakamura, 2006, Osteoarthritis and cartilage.

METHODOLOGICAL APPROACH TO EVALUATE THE EFFECTS OF MUSCLE REMOVAL ON ESTIMATED MUSCLE FORCES DURING WALKING IN PATIENTS AFTER RESECTION OF SOFT TISSUE SARCOMA IN THE THIGH

J. Toguchida, N. Ichihashi, N. Tatematsu, 2020 .

p53 expression and its relationship to DNA alterations in bone and soft tissue sarcomas.

J. Toguchida, T. Yamamuro, M. Sasaki, 1993, British Journal of Cancer.

Influence of Cigarette Smoking and Schistosomiasis on p53 Gene Mutation in Urothelial Cancer1

Taketoshi, K. Ishizaki, O. Yoshida, 2006 .

Neofunction of ACVR1 in fibrodysplasia ossificans progressiva

Y. Matsumoto, S. Matsuda, J. Toguchida, 2015, Proceedings of the National Academy of Sciences.

Regeneration of Osteonecrosis of Canine Scapho-lunate Using Bone Marrow Stromal Cells: Possible Therapeutic Approach for Kienböck Disease

J. Toguchida, T. Azuma, T. Aoyama, 2006, Cell transplantation.

Highly efficient cryopreservation of human induced pluripotent stem cells using a dimethyl sulfoxide-free solution.

H. Iwata, Y. Teramura, J. Toguchida, 2011, The International journal of developmental biology.

A case report of pathologically complete response of a huge rectal cancer after systemic chemotherapy with mFOLFOX6.

A. Yoshizawa, J. Toguchida, S. Nagayama, 2009, Japanese journal of clinical oncology.

Neuronal Differentiation of Synovial Sarcoma and Its Therapeutic Application

Tomoki Aoyama, Junya Toguchida, Takashi Nakamura, 2008, Clinical orthopaedics and related research.

SS18-SSX, the Oncogenic Fusion Protein in Synovial Sarcoma, Is a Cellular Context-Dependent Epigenetic Modifier

K. Woltjen, J. Toguchida, T. Okamoto, 2015, PloS one.

Clonal heterogeneity in differentiation potential of immortalized human mesenchymal stem cells.

Tomoki Aoyama, Tohru Kiyono, Junya Toguchida, 2002, Biochemical and biophysical research communications.

Derivation of Mesenchymal Stromal Cells from Pluripotent Stem Cells through a Neural Crest Lineage using Small Molecule Compounds with Defined Media

Y. Matsumoto, N. Koizumi, J. Toguchida, 2014, PloS one.

Expression of vascular cell adhesion molecule-1 indicates the differentiation potential of human bone marrow stromal cells.

Takashi Nakamura, J. Toguchida, M. Neo, 2008, Biochemical and biophysical research communications.

Clonal Analysis of Hematopoiesis-Supporting Activity of Human Mesenchymal Stem Cells in Association with Jagged1 Expression and Osteogenic Potential

H. Iwata, J. Toguchida, S. Fujita, 2008, Cell transplantation.

Recombinant matrix protein for maintenance of undifferentiated primate embryonic stem cells.

H. Iwata, J. Toguchida, H. Suemori, 2007, Tissue engineering.

Microencapsulated feeder cells as a source of soluble factors for expansion of CD34(+) hematopoietic stem cells.

H. Iwata, J. Toguchida, S. Fujita, 2007, Biomaterials.

Risk factors of local recurrence after surgery in extraabdominal desmoid‐type fibromatosis: A multicenter study in Japan

T. Matsunobu, J. Toguchida, T. Ozaki, 2020, Cancer science.

Genetically Matched Human iPS Cells Reveal that Propensity for Cartilage and Bone Differentiation Differs with Clones, not Cell Type of Origin

Y. Matsumoto, Takashi Nakamura, J. Toguchida, 2013, PloS one.

Title Enhanced Chondrogenesis of Induced Pluripotent Stem Cells From Patients With Neonatal-Onset Multisystem Inflammatory Disease Occurs via the Caspase 1-Independent cAMP / Protein Kinase

O. Ohara, Y. Matsumoto, J. Toguchida, 2019 .

Force-speci fi c activation of Smad 1 / 5 regulates vascular endothelial cell cycle progression in response to disturbed fl ow

P. Hainaut, P. Dubus, K. Chébli, 2012 .

mRNA expression levels of E2F transcription factors correlate with dihydrofolate reductase, reduced folate carrier, and thymidylate synthase mRNA expression in osteosarcoma.

A. Huvos, D. Banerjee, J. Bertino, 2003, Molecular cancer therapeutics.

Allelotype Analysis in Osteosarcomas: Frequent AlÃ eleLoss on 3q, 13q, 17p, and ISq1

Yusuke Nakamura, M. Sasaki, Y. Kaneko, 2006 .

Mutations in the retinoblastoma gene and their expression in somatic and tumor cells of patients with hereditary retinoblastoma

K. Ishizaki, M. Sasaki, H. Tanooka, 1994, Human mutation.

Detection of mutations of the RB1 gene in retinoblastoma patients by using exon-by-exon PCR-SSCP analysis.

K. Ishizaki, M. Sasaki, J. Toguchida, 1994, American journal of human genetics.

Morphological and biological heterogeneity of three tumorigenic cell lines derived from a single p53-/- osteoblast-like cell line, MMC2.

J. Toguchida, T. Aoyama, T. Tsuboyama, 2002, Cancer letters.

Prognostic factors of pulmonary metastasectomy for osteosarcomas of the extremities.

H. Date, J. Toguchida, K. Okubo, 2008, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

Human iPSC-derived hypertrophic chondrocytes reveal a mutation-specific unfolded protein response in chondrodysplasias

T. Futami, J. Toguchida, Z. Wang, 2020, bioRxiv.

Computer-Assisted Spinal Osteotomy: A Technical Note and Report of Four Cases

J. Toguchida, M. Neo, Takashi Nakamura, 2010, Spine.

Inverse correlation of the up‐regulation of FZD10 expression and the activation of β‐catenin in synchronous colorectal tumors

Yusuke Nakamura, T. Katagiri, J. Toguchida, 2009, Cancer science.

IGF2 preserves osteosarcoma cell survival by creating an autophagic state of dormancy that protects cells against chemotherapeutic stress.

H. Ikeda, N. Onishi, H. Saya, 2014, Cancer research.

High incidence of SV40-like sequences detection in tumour and peripheral blood cells of Japanese osteosarcoma patients

H. Yamamoto, J. Toguchida, T. Tsuboyama, 2000, British Journal of Cancer.

Mesenchymal stem cells cultured under hypoxia escape from senescence via down-regulation of p16 and extracellular signal regulated kinase.

Takashi Nakamura, J. Toguchida, T. Aoyama, 2010, Biochemical and biophysical research communications.

Prophylactic treatment of rapamycin ameliorates naturally developing and episode -induced heterotopic ossification in mice expressing human mutant ACVR1

S. Matsuda, J. Toguchida, H. Yoshitomi, 2020, Orphanet Journal of Rare Diseases.

Definitive intraoperative very high-dose radiotherapy for localized osteosarcoma in the extremities.

Y. Shibamoto, Y. Nishimura, M. Hiraoka, 2001, International journal of radiation oncology, biology, physics.

Syndactyly and preaxial synpolydactyly in the single Sfrp2 deleted mutant mice

R. Matsui, J. Toguchida, K. Tashiro, 2008, Developmental dynamics : an official publication of the American Association of Anatomists.

Bilateral phlegmasia dolens associated with Trousseau's syndrome: a case report.

J. Toguchida, T. Aoyama, Takashi Nakamura, 2008, Archives of physical medicine and rehabilitation.

Recapitulating the human segmentation clock with pluripotent stem cells

Long Guo, Michiko Nakamura, Miki Ebisuya, 2020, Nature.

Enhanced Chondrogenesis of Induced Pluripotent Stem Cells From Patients With Neonatal‐Onset Multisystem Inflammatory Disease Occurs via the Caspase 1–Independent cAMP/Protein Kinase A/CREB Pathway

O. Ohara, Y. Matsumoto, J. Toguchida, 2015, Arthritis & rheumatology.

PGE2 signal via EP2 receptors evoked by a selective agonist enhances regeneration of injured articular cartilage.

J. Toguchida, T. Aoyama, T. Maruyama, 2009, Osteoarthritis and cartilage.

Institutional report - Thoracic oncologic Repeat resection of pulmonary metastasis is beneficial for patients with osteosarcoma of the extremities

H. Date, J. Toguchida, K. Okubo, 2009 .

Clinical Outcomes of Patients With Osteosarcoma Experiencing Relapse or Progression: A Single-institute Experience

H. Date, J. Takita, A. Sakamoto, 2022, Journal of pediatric hematology/oncology.

Perioperative Adriamycin plus ifosfamide vs. gemcitabine plus docetaxel for high-risk soft tissue sarcomas: randomised, phase II/III study JCOG1306

Y. Iwamoto, J. Toguchida, T. Ozaki, 2022, British Journal of Cancer.

A case of a ewing sarcoma family tumor in the urinary bladder after treatment for acute lymphoblastic leukemia.

J. Toguchida, H. Hosoi, J. Hata, 2007, Journal of pediatric hematology/oncology.

Analysis of neural crest cells from Charcot–Marie–Tooth disease patients demonstrates disease-relevant molecular signature

J. Toguchida, Takuya Yamamoto, M. Nakagawa, 2017, Neuroreport.

New Protocol to Optimize iPS Cells for Genome Analysis of Fibrodysplasia Ossificans Progressiva

Y. Matsumoto, J. Toguchida, Takuya Yamamoto, 2015, Stem cells.

Feasibility and efficacy of gemcitabine and docetaxel combination chemotherapy for bone and soft tissue sarcomas: multi-institutional retrospective analysis of 134 patients

H. Yoshikawa, Y. Iwamoto, J. Toguchida, 2016, World Journal of Surgical Oncology.

Regenerative medicine for bone diseases using mesenchymal stem cells

J. Toguchida, 2013 .

Natural course of desmoid-type fibromatosis

Takashi Nakamura, J. Toguchida, T. Tsuboyama, 2008, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association.

Frequent p53 gene mutations in blast crisis of chronic myelogenous leukemia, especially in myeloid crisis harboring loss of a chromosome 17p.

K. Ishizaki, S. Misawa, H. Nakai, 1992, Cancer research.

Correlation of L-myc genotypes to metastasis of gastric cancer and breast cancer.

K. Ishizaki, M. Ikenaga, J. Toguchida, 1990, Journal of the National Cancer Institute.

Differentiation of Hypertrophic Chondrocytes from Human iPSCs for the In Vitro Modeling of Chondrodysplasias

T. Futami, J. Toguchida, S. Ikegawa, 2021, Stem cell reports.

Identification of target genes of synovial sarcoma-associated fusion oncoprotein using human pluripotent stem cells.

K. Woltjen, J. Toguchida, Shingo Sato, 2013, Biochemical and biophysical research communications.

Recipient bone marrow‐derived stromal cells prolong graft survival in a rat hind limb allotransplantation model

S. Matsuda, J. Toguchida, T. Aoyama, 2017, Microsurgery.

A clinical trial for Kienböck disease by cultured autologous multipotent mesenchymal stromal cells augmented with vascularized bone grafts: A report of five cases.

S. Matsuda, J. Toguchida, T. Aoyama, 2017, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association.

Modeling the Human Segmentation Clock with Pluripotent Stem Cells

Long Guo, Michiko Nakamura, Miki Ebisuya, 2019, bioRxiv.

TLS‐CHOP target gene DOL54 expression in liposarcomas and malignant fibrous histiocytomas

T. Ohbayashi, T. Ishida, J. Toguchida, 2002, Pathology international.

In vitro bone-like nodules generated from patient-derived iPSCs recapitulate pathological bone phenotypes

T. Adachi, S. Matsuda, J. Toguchida, 2019, Nature Biomedical Engineering.

Rigid reconstruction with periacetabular multiple screws after the resection of malignant pelvic tumours involving the sacroiliac joint

S. Matsuda, A. Sakamoto, J. Toguchida, 2021, International Orthopaedics.

Induction and expansion of human PRRX1+ limb-bud-like mesenchymal cells from pluripotent stem cells

J. Toguchida, A. Yoshida, T. Ozaki, 2021, Nature Biomedical Engineering.

Recapitulation of pro-inflammatory signature of monocytes with ACVR1A mutation using FOP patient-derived iPSCs

J. Toguchida, A. Niwa, M. Saito, 2022, Orphanet Journal of Rare Diseases.

Attachment of artificial cartilage to underlying bone.

J. Toguchida, S. Hyon, Takashi Nakamura, 2004, Journal of biomedical materials research. Part B, Applied biomaterials.

A novel method to isolate mesenchymal stem cells from bone marrow in a closed system using a device made by nonwoven fabric.

S. Kimura, J. Toguchida, T. Aoyama, 2010, Tissue engineering. Part C, Methods.

Cell therapy for avascular osteonecrosis of femoral head

J. Toguchida, T. Aoyama, 2009, Journal of stem cells & regenerative medicine.

Prevalence and spectrum of germline mutations of the p53 gene among patients with sarcoma.

R. Weichselbaum, J. Little, K. Ishizaki, 1992, The New England journal of medicine.

Giant cell tumor of bone – Analysis of 213 cases involving extra‐craniofacial bones

N. Naka, J. Toguchida, Hidetatsu Outani, 2021, Pathology international.

Chondroblastoma of extra‐craniofacial bones: Clinicopathological analyses of 103 cases

T. Kubo, H. Yoshikawa, E. Morii, 2017, Pathology international.

Primary central chondrosarcoma of long bone, limb girdle and trunk: Analysis of 174 cases by numerical scoring on histology

T. Kubo, H. Yoshikawa, K. Wakasa, 2015, Pathology international.

Application of iPS Cell Technology for OPLL

J. Toguchida, 2020 .

Association of the human NPPS gene with ossification of the posterior longitudinal ligament of the spine (OPLL)

Kozo Nakamura, Y. Nakamura, K. Takaoka, 1999, Human Genetics.

Mutation spectrum of the retinoblastoma gene in osteosarcomas.

K. Ishizaki, M. Sasaki, J. Toguchida, 1994, Cancer research.

Endovascular papillary angioendothelioma (Dabska tumor) of bone.

J. Toguchida, M. Nishino, K. Hayakawa, 2004, Orthopedics.

Bone remodelling around implanted materials under load-bearing conditions

J. Toguchida, T. Nakamura, M. Oka, 1997 .

Donor-dependent variations in hepatic differentiation from human-induced pluripotent stem cells

Takashi Aoi, Shinya Yamanaka, Koji Eto, 2012, Proceedings of the National Academy of Sciences.

Allele-specific hypermethylation of the retinoblastoma tumor-suppressor gene.

T. Dryja, T. Sakai, N. Ohtani, 1991, American journal of human genetics.

Human Sox4 facilitates the development of CXCL13-producing helper T cells in inflammatory environments

S. Matsuda, J. Toguchida, K. Nishitani, 2018, Nature Communications.

Somatic mosaicism for DNA repair capacity in fibroblasts derived from a group A xeroderma pigmentosum patient.

Y. Nakamura, K. Ishizaki, M. Sasaki, 1989, The Journal of investigative dermatology.

Chromosomal reorganization for the expression of recessive mutation of retinoblastoma susceptibility gene in the development of osteosarcoma.

K. Ishizaki, M. Sasaki, M. Ikenaga, 1988, Cancer research.

Unique mutation portraits and frequent COL2A1 gene alteration in chondrosarcoma

S. Miyano, Y. Totoki, F. Hosoda, 2014, Genome research.

Characteristics of genomic breakpoints in TLS-CHOP translocations in liposarcomas suggest the involvement of Translin and topoisomerase II in the process of translocation

M. Sasaki, D. Ron, J. Toguchida, 1999, Oncogene.

The Transcription Factor Sp3 Regulates the Expression of a Metastasis-Related Marker of Sarcoma, Actin Filament-Associated Protein 1-Like 1 (AFAP1L1)

Yusuke Nakamura, T. Katagiri, H. Nishiyama, 2013, PloS one.

Genome-wide analysis of gene expression in synovial sarcomas using a cDNA microarray.

Yusuke Nakamura, T. Tsunoda, T. Katagiri, 2002, Cancer research.

Species-specific segmentation clock periods are due to differential biochemical reaction speeds

J. García-Ojalvo, R. Kageyama, Miki Ebisuya, 2020, Science.

A novel type of EWS-CHOP fusion gene in two cases of myxoid liposarcoma.

N. Araki, J. Toguchida, H. Murata, 2002, The Journal of molecular diagnostics : JMD.

Modeling human somite development and fibrodysplasia ossificans progressiva with induced pluripotent stem cells

J. Toguchida, H. Sakurai, C. Alev, 2018, Development.

The molecular chaperone Hsp47 is essential for cartilage and endochondral bone formation

J. Toguchida, Hiroaki Nakamura, A. Hosoya, 2012, Journal of Cell Science.

BMP-SMAD-ID promotes reprogramming to pluripotency by inhibiting p16/INK4A-dependent senescence

B. Conklin, E. Hsiao, S. Yamanaka, 2016, Proceedings of the National Academy of Sciences.

Mutant IDH1 Dysregulates the Differentiation of Mesenchymal Stem Cells in Association with Gene-Specific Histone Modifications to Cartilage- and Bone-Related Genes

K. Woltjen, S. Matsuda, J. Toguchida, 2015, PloS one.

Loss of 17 p , Mutation of the p 53 Gene , and Overexpression of p 53 Protein in Esophageal Squamous Cell Carcinomas 1

M. Imamura, K. Ishizaki, M. Ikenaga, 2006 .

Loss of 17p, mutation of the p53 gene, and overexpression of p53 protein in esophageal squamous cell carcinomas.

M. Imamura, K. Ishizaki, M. Ikenaga, 1993, Cancer research.

Development of Osteosarcoma Mutation of Retinoblastoma Susceptibility Gene in the Chromosomal Reorganization for the Expression of Recessive Updated

K. Ishizaki, M. Sasaki, M. Ikenaga, 2006 .

Subregion 17 p 13 Assignment of Common Allele Loss in Osteosarcoma to the Updated Version

Yusuke Nakamura, M. Ikenaga, J. Toguchida, 2006 .

Assignment of Common AlÃ-eleLoss in Osteosarcoma to the Subregion 17 pl 3 '

Yusuke Nakamura, K. Ishizaki, M. Sasaki, 2006 .

Histone Modifiers, YY1 and p300, Regulate the Expression of Cartilage-specific Gene, Chondromodulin-I, in Mesenchymal Stem Cells*

Takashi Nakamura, J. Toguchida, T. Aoyama, 2010, The Journal of Biological Chemistry.

Increased frequency of specific alleles of the c-Ha-ras gene in Japanese cancer patients

T. Inamoto, K. Ishizaki, M. Ikenaga, 1988, Human Genetics.

EWS/ATF1 expression induces sarcomas from neural crest-derived cells in mice.

A. Hara, J. Toguchida, K. Shimizu, 2013, The Journal of clinical investigation.

Elevated frequency of a specific allele of the l‐MYC gene in male patients with bone and soft‐tissue sarcomas

K. Ishizaki, M. Sasaki, M. Ikenaga, 1990, International journal of cancer.

Current state of therapeutic development for rare cancers in Japan, and proposals for improvement

T. Shibata, M. Monden, R. Ueda, 2018, Cancer science.

MDM2 gene amplification in bone and soft‐tissue tumors: Association with tumor progression in differentiated adipose‐tissue tumors

M. Sasaki, J. Toguchida, Y. Kotoura, 1995, International journal of cancer.

Translin binds to the sequences adjacent to the breakpoints of the TLS and CHOP genes in liposarcomas with translocation t(12;16)

M. Sasaki, J. Toguchida, T. Tsuboyama, 2000, Oncogene.

Cell-specific epigenetic regulation of ChM-I gene expression: crosstalk between DNA methylation and histone acetylation.

Takashi Nakamura, J. Toguchida, T. Aoyama, 2008, Biochemical and biophysical research communications.

Identification of AFAP1L1 as a prognostic marker for spindle cell sarcomas

T. Katagiri, Y. Nakamura, S. Imoto, 2011, Oncogene.

Methylation in the Core-promoter Region of the Chondromodulin-I Gene Determines the Cell-specific Expression by Regulating the Binding of Transcriptional Activator Sp3*

Takashi Nakamura, J. Toguchida, T. Aoyama, 2004, Journal of Biological Chemistry.

Establishment of an osteoblast-like cell line, MMC2, from p53-deficient mice.

J. Toguchida, M. Sasaki, T. Nakamura, 1997, Bone.

Preferential mutation of paternally derived RB gene as the initial event in sporadic osteosarcoma

Yusuke Nakamura, K. Ishizaki, M. Sasaki, 1989, Nature.

Disruption of Fibroblast Growth Factor Signal Pathway Inhibits the Growth of Synovial Sarcomas: Potential Application of Signal Inhibitors to Molecular Target Therapy

Yusuke Nakamura, T. Katagiri, Takashi Nakamura, 2005, Clinical Cancer Research.

Gene Expression Profiling of Synovial Sarcoma: Distinct Signature of Poorly Differentiated Type

Teruhiko Yoshida, Y. Toyama, J. Toguchida, 2010, The American journal of surgical pathology.

The Id2 gene is a novel target of transcriptional activation by EWS-ETS fusion proteins in Ewing family tumors

Yusuke Nakamura, Toshihiro Tanaka, Y. Sasaki, 2002, Oncogene.

Parental origin of germ-line and somatic mutations in the retinoblastoma gene

K. Ishizaki, M. Sasaki, H. Tanooka, 1994, Human Genetics.

Complete genomic sequence of the human retinoblastoma susceptibility gene.

T. L. McGee, T. Dryja, J. Toguchida, 1993, Genomics.

Runx3 is required for oncogenic Myc upregulation in p53-deficient osteosarcoma

Tomoko Ito, J. Toguchida, T. Komori, 2021, Oncogene.

The oncogenic Runx3–Myc axis defines p53-deficient osteosarcomagenesis

Tomoko Ito, J. Toguchida, T. Komori, 2021, bioRxiv.

Activation of the non-canonical Dvl–Rac1–JNK pathway by Frizzled homologue 10 in human synovial sarcoma

Yusuke Nakamura, T. Tsunoda, T. Katagiri, 2009, Oncogene.

A Novel Human Artificial Chromosome Vector Provides Effective Cell Lineage–Specific Transgene Expression in Human Mesenchymal Stem Cells

M. Oshimura, A. Kurimasa, J. Toguchida, 2005, Stem cells.

Involvement of Extracellular Signal-Regulated Kinase Activation in Human Osteosarcoma Cell Resistance to the Histone Deacetylase Inhibitor FK228 [(1S,4S,7Z,10S,16E,21R)-7-Ethylidene-4,21-bis(propan-2-yl)-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone]

J. Toguchida, S. Adachi, T. Nakahata, 2009, Journal of Pharmacology and Experimental Therapeutics.

Synthetic osteochondral replacement of the femoral articular surface.

J. Toguchida, T. Nakamura, M. Oka, 1997, Journal of Bone and Joint Surgery-british Volume.

Histologic comparison of tibial articular surfaces against rigid materials and artificial articular cartilage.

J. Toguchida, T. Nakamura, M. Oka, 1997, Journal of biomedical materials research.

Molecular genetics of sarcomas: Applications to diagnoses and therapy

J. Toguchida, T. Nakayama, 2009, Cancer science.

AFAP1L1, a novel associating partner with vinculin, modulates cellular morphology and motility, and promotes the progression of colorectal cancers

S. Imoto, J. Toguchida, R. Takahashi, 2014, Cancer medicine.

A case of primary synovial sarcoma of the thorax with a variant SYT-SSX1 fusion transcript.

J. Toguchida, S. Yasuda, Y. Kohno, 2009, The Annals of thoracic surgery.

Species-specific oscillation periods of human and mouse segmentation clocks are due to cell autonomous differences in biochemical reaction parameters

J. García-Ojalvo, R. Kageyama, Miki Ebisuya, 2019, bioRxiv.

Delayed development of retinoblastoma associated with loss of a maternal allele on chromosome 13

K. Ishizaki, M. Sasaki, J. Toguchida, 1995, International journal of cancer.

Induction of autophagy in malignant rhabdoid tumor cells by the histone deacetylase inhibitor FK228 through AIF translocation

S. Toyokuni, J. Toguchida, S. Adachi, 2009, International journal of cancer.

In Vitro Demonstration of Cell‐to‐Cell Interaction in Growth Plate Cartilage Using Chondrocytes Established From p53−/− Mice

Takashi Nakamura, J. Toguchida, T. Aoyama, 2003, Journal of Bone and Mineral Research.

Loss of heterozygosity on chromosome 17 and mutation of the p53 gene in retinoblastoma.

K. Ishizaki, M. Sasaki, J. Toguchida, 1996, Cancer letters.

Therapeutic potential of antibodies against FZD10, a cell-surface protein, for synovial sarcomas

Yusuke Nakamura, T. Katagiri, M. Imamura, 2005, Oncogene.

Screening of BCOR‐CCNB3 sarcoma using immunohistochemistry for CCNB3: A clinicopathological report of three pediatric cases

A. Yoshizawa, J. Toguchida, T. Sakurai, 2015, Pathology international.

Prospective comparison of various radiological response criteria and pathological response to preoperative chemotherapy and survival in operable high-grade soft tissue sarcomas in the Japan Clinical Oncology Group study JCOG0304

H. Yoshikawa, Y. Iwamoto, H. Tsuchiya, 2018, World Journal of Surgical Oncology.

Cell-type dependent enhancer binding of the EWS/ATF1 fusion gene in clear cell sarcomas

K. Woltjen, J. Toguchida, H. Akiyama, 2019, Nature Communications.

Prognostic implication of SYT-SSX fusion type in synovial sarcoma: a multi-institutional retrospective analysis in Japan.

H. Yoshikawa, Y. Iwamoto, N. Naka, 2008, Oncology reports.

Radioimmunotherapy of human synovial sarcoma using a monoclonal antibody against FZD10

Yusuke Nakamura, T. Tsunoda, T. Katagiri, 2008, Cancer science.

Correction of kyphotic deformity of the cervical spine in ankylosing spondylitis using general anesthesia and internal fixation.

J. Toguchida, K. Shimizu, T. Nakamura, 1996, Journal of spinal disorders.

In vitro bone-like nodules generated from patient-derived iPSCs recapitulate pathological bone phenotypes

T. Adachi, S. Matsuda, J. Toguchida, 2019, Nature Biomedical Engineering.

Culture substrate‐associated YAP inactivation underlies chondrogenic differentiation of human induced pluripotent stem cells

J. Toguchida, N. Tsumaki, H. Yoshitomi, 2020, Stem cells translational medicine.

Amplification of the CDK4 gene in sarcomas: tumor specificity and relationship with the RB gene mutation.

H. Yamamoto, J. Toguchida, M. Sasaki, 1998, Anticancer research.

SYT‐SSX breakpoint peptide vaccines in patients with synovial sarcoma: A study from the Japanese Musculoskeletal Oncology Group

K. Ida, T. Yamashita, H. Tsuchiya, 2012, Cancer science.

FR901228 induces tumor regression associated with induction of Fas ligand and activation of Fas signaling in human osteosarcoma cells

J. Toguchida, S. Yonehara, S. Adachi, 2003, Oncogene.

Immunomodulation by Mesenchymal Stem Cells in Composite Tissue Allotransplantation

K. Kawanabe, J. Toguchida, S. Fujita, 2011 .

An mTOR Signaling Modulator Suppressed Heterotopic Ossification of Fibrodysplasia Ossificans Progressiva

J. Toguchida, Yasuhiro Yamada, K. Hino, 2018, Stem cell reports.

3D osteogenic differentiation of human iPSCs reveals the role of TGFβ signal in the transition from progenitors to osteoblasts and osteoblasts to osteocytes

J. Toguchida, Liping Sun, Taiji Adachi, 2023, Scientific Reports.

Genetics of Osteosarcoma

J. Toguchida, 2016 .

Title Human Sox 4 facilitates the development of CXCL 13-producing helper T cells in inflammatory environments

S. Matsuda, J. Toguchida, K. Nishitani, 2019 .

Recapitulating the human segmentation clock with pluripotent stem cells

Long Guo, Miki Ebisuya, Mitsuhiro Matsuda, 2020, Nature.

Clinical features and treatment outcome of desmoid-type fibromatosis: based on a bone and soft tissue tumor registry in Japan

Kunihiko Takahashi, T. Matsunobu, J. Toguchida, 2019, International Journal of Clinical Oncology.

Rehabilitation program after mesenchymal stromal cell transplantation augmented by vascularized bone grafts for idiopathic osteonecrosis of the femoral head: a preliminary study.

S. Matsuda, J. Toguchida, M. Yamada, 2015, Archives of physical medicine and rehabilitation.

Somatic and germinal mutations of tumor-suppressor genes in the development of cancer.

K. Ishizaki, H. Tanooka, Y. Ejima, 1991, Journal of radiation research.

Prostaglandin E2 receptor type 2-selective agonist prevents the degeneration of articular cartilage in rabbit knees with traumatic instability

J. Toguchida, T. Aoyama, T. Maruyama, 2011, Arthritis research & therapy.

Mutation analysis of the RECQL4 gene in sporadic osteosarcomas

J. Toguchida, T. Aoyama, T. Tsuboyama, 2004, International journal of cancer.

Phenotypic differences of patients with fibrodysplasia ossificans progressive due to p.Arg258Ser variants of ACVR1

J. Toguchida, N. Haga, Ryuyo Suzuki, 2015, Human Genome Variation.

Longitudinal study of the activities of daily living and quality of life in Japanese patients with fibrodysplasia ossificans progressiva

J. Toguchida, N. Haga, H. Kitoh, 2019, Disability and rehabilitation.

Human Sox4 facilitates the development of CXCL13-producing helper T cells in inflammatory environments

S. Matsuda, J. Toguchida, K. Nishitani, 2018, Nature Communications.

Mutation analyses of the NFAT1 gene in chondrosarcomas and enchondromas.

J. Toguchida, T. Aoyama, T. Tsuboyama, 2002, Cancer letters.

Loss of heterozygosity and tumor suppressor gene mutations in chondrosarcomas.

K. Ishizaki, M. Ikenaga, J. Toguchida, 1996, Anticancer research.

Validation of radiographic response evaluation criteria of preoperative chemotherapy for bone and soft tissue sarcomas: Japanese Orthopaedic Association Committee on Musculoskeletal Tumors Cooperative Study

H. Yoshikawa, Y. Iwamoto, H. Tsuchiya, 2008, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association.

Expression of the chondromodulin-I gene in chondrosarcomas.

J. Toguchida, T. Aoyama, T. Tsuboyama, 2004, Cancer letters.

Prediction of response to neoadjuvant chemotherapy for osteosarcoma by gene-expression profiles.

Yusuke Nakamura, T. Tsunoda, T. Katagiri, 2004, International journal of oncology.

Effect of a Rehabilitation Program After Mesenchymal Stromal Cell Transplantation for Advanced Osteonecrosis of the Femoral Head: A 10-Year Follow-Up Study

J. Toguchida, T. Aoyama, M. Nankaku, 2022, Archives of rehabilitation research and clinical translation.

Collagen X Is Dispensable for Hypertrophic Differentiation and Endochondral Ossification of Human iPSC‐Derived Chondrocytes

J. Toguchida, Megumi Nishio, Sanae Nagata, 2023, JBMR plus.

Development of an osteosarcoma model with MYCN amplification and TP53 mutation in hiPS cell‐derived neural crest cells

M. Ohira, T. Kamijo, J. Toguchida, 2023, Cancer science.

DietaryNutrientIntakesand SlightAlbuminuria in Peopleat Least40 Years Old

D. Slamon, J. Toguchida, F. Imazeki, 1993 .

Isolation of bone marrow stromal cells from bone marrow by using a filtering device (method)

J. Toguchida, T. Aoyama, 2012 .

Polymorphisms of B7 (CD80 and CD86) Genes Do Not Affect Disease Susceptibility to Sarcoidosis

M. Mishima, M. Kitaichi, J. Toguchida, 2005, Respiration.

p 53 Protein in Esophageal Squamous Cell Carcinomas Gene , and Overexpression of p 53 Loss of 17 p , Mutation of the Updated

M. Imamura, K. Ishizaki, M. Ikenaga, 2006 .

Identification of PDZK4, a novel human gene with PDZ domains, that is upregulated in synovial sarcomas

Yusuke Nakamura, T. Katagiri, Megumi Iiizumi, 2004, Oncogene.

Inhibition of RANKL Expression in Osteocyte-like Differentiated Tumor Cells in Giant Cell Tumor of Bone After Denosumab Treatment

A. Sakamoto, J. Toguchida, Yosuke Yamada, 2023, Journal of Histochemistry and Cytochemistry.

Current status of multipotent mesenchymal stromal cells.

R. Puri, Y. Ohya, J. Toguchida, 2014, Tissue engineering. Part B, Reviews.

Involvement of cancer biomarker C7orf24 in the growth of human osteosarcoma.

Takashi Nakamura, J. Toguchida, T. Aoyama, 2011, Anticancer research.

Disruption of Fibroblast Growth Factor Signal Pathway Inhibits the Growth of Synovial Sarcomas: Potential Application of Signal Inhibitors to Molecular Target Therapy

Yusuke Nakamura, T. Katagiri, Takashi Nakamura, 2005, Clinical Cancer Research.

Expression of vascular cell adhesion molecule-1 indicates the differentiation potential of human bone marrow stromal cells.

Takashi Nakamura, J. Toguchida, M. Neo, 2008, Biochemical and biophysical research communications.

Automated cell culture system for the production of cell aggregates with growth plate-like structure from induced pluripotent stem cells.

J. Toguchida, Megumi Nishio, Sanae Nagata, 2023, SLAS technology.

Frequency and structure of p53 rearrangements in human osteosarcoma.

D. Slamon, H. Koeffler, C. Miller, 1990, Cancer research.

Bi-allelic loss of function variants of TBX6 causes a spectrum of malformation of spine and rib including congenital scoliosis and spondylocostal dysostosis

Long Guo, N. Matsumoto, J. Toguchida, 2019, Journal of Medical Genetics.

Intramuscular metastasis from gastric cancer

M. Imamura, J. Toguchida, Shugen Kan, 2002, Gastric Cancer.

Mediastinal Synovial Sarcoma

H. Wada, J. Toguchida, T. Fukuse, 2009, The Thoracic and cardiovascular surgeon.

Recognition of serum alkaline phosphatase by murine monoclonal antibodies against human osteosarcoma cells.

J. Toguchida, T. Yamamuro, Y. Kotoura, 1986, Cancer research.

IKKβ in postnatal perichondrium remotely controls endochondral ossification of the growth plate through downregulation of MCP-5

M. Karin, J. Toguchida, T. Kato, 2014, Cell Death and Differentiation.

Fracture healing is a process independent of p53 function.

J. Toguchida, M. Sasaki, T. Nakamura, 1996, In vivo.

PCR detection of the Tth 111 I RFLP at the RB locus.

T. L. McGee, T. Dryja, J. Toguchida, 1990, Nucleic Acids Research.

O. Ohara, Y. Matsumoto, J. Toguchida, 2015, Arthritis & rheumatology.

Neofunction of ACVR1 in fibrodysplasia ossificans progressiva

Y. Matsumoto, S. Matsuda, J. Toguchida, 2015, Proceedings of the National Academy of Sciences.

Oxidative phosphorylation is a pivotal therapeutic target of fibrodysplasia ossificans progressiva

J. Toguchida, Megumi Nishio, Sanae Nagata, 2024, Life Science Alliance.

Gene expression profile of macrophage-like U937 cells in response to polyethylene particles: a novel cell-particle culture system.

K. Kawanabe, J. Toguchida, Takashi Nakamura, 2007, The Journal of arthroplasty.

Screening of BCOR‐CCNB3 sarcoma using immunohistochemistry for CCNB3: A clinicopathological report of three pediatric cases

A. Yoshizawa, J. Toguchida, T. Sakurai, 2015, Pathology international.

The effect of walking speed on gait kinematics and kinetics after endoprosthetic knee replacement following bone tumor resection.

S. Matsuda, J. Toguchida, N. Ichihashi, 2014, Gait & posture.

Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency.

K. Dobbs, B. Boisson, J. Toguchida, 2024, Nature immunology.

Heterozygous mutations in the straitjacket region of the latency-associated peptide domain of TGFB2 cause Camurati-Engelmann disease type II.

Long Guo, K. Yoshiura, M. Shiina, 2024, Journal of human genetics.

Disease modeling and drug discovery utilizing iPS cells

Junya Toguchida, J. Toguchida, 2019, Tenri Medical Bulletin.

Recapitulation of pro-inammatory signature of monocytes with ACVR1 mutation using FOP patient-derived iPSCs.

J. Toguchida, M. Saito, Megumi Nishio, 2022 .