A. Fassihi

发表

Homology modeling of human CCR5 and analysis of its binding properties through molecular docking and molecular dynamics simulation.

M. Shahlaei, A. Madadkar-Sobhani, K. Mahnam, 2011, Biochimica et biophysica acta.

Application of partial least squares and radial basis function neural networks in multivariate imaging analysis-quantitative structure activity relationship: study of cyclin dependent kinase 4 inhibitors.

Afshin Fassihi, Mohsen Shahlaei, Armin Madadkar-Sobhani, 2010, Journal of molecular graphics & modelling.

Molecular Dynamics Simulation of Chemokine Receptors in Lipid Bilayer: A Case Study on C–C Chemokine Receptor Type 2

M. Shahlaei, E. Papaleo, A. Fassihi, 2013, Chemical biology & drug design.

Statistically validated QSAR study of some antagonists of the human CCR5 receptor using least square support vector machine based on the genetic algorithm and factor analysis

A. Fassihi, E. Arkan, Mohsen Shahlaie, 2013, Medicinal Chemistry Research.

Synthesis and calcium antagonist activity of 1,4-dihydropyridines containing phenylaminoimidazolyl substituents.

A. Fassihi, A. Zarghi, A. Shafiee, 2003, Farmaco.

QSAR and docking studies of some 1,2,3,4-tetrahydropyrimidines: evaluation of gp41 as possible target for anti-HIV-1 activity

A. Fassihi, L. Saghaie, S. Sepehri, 2015, Medicinal Chemistry Research.

QSAR study of anthranilic acid sulfonamides as inhibitors of methionine aminopeptidase-2 using LS-SVM and GRNN based on principal components.

Afshin Fassihi, Mohsen Shahlaei, Razieh Sabet, 2010, European journal of medicinal chemistry.

Validated QSAR analysis of some diaryl substituted pyrazoles as CCR2 inhibitors by various linear and nonlinear multivariate chemometrics methods.

Afshin Fassihi, Mohsen Shahlaei, Elham Arkan, 2010, European journal of medicinal chemistry.

Application of PC-ANN and PC-LS-SVM in QSAR of CCR1 antagonist compounds: a comparative study.

Afshin Fassihi, Mohsen Shahlaei, Lotfollah Saghaie, 2010, European journal of medicinal chemistry.

QSAR study of anthranilic acid sulfonamides as methionine aminopeptidase-2 inhibitors

M. Shahlaei, A. Fassihi, Razieh Sabet, 2012, Monatshefte für Chemie - Chemical Monthly.

Computational evaluation of some indenopyrazole derivatives as anticancer compounds; application of QSAR and docking methodologies

Afshin Fassihi, Mohsen Shahlaei, Armin Madadkar-Sobhani, 2013, Journal of enzyme inhibition and medicinal chemistry.

Dual thermo- and pH-responsive poly(N-isopropylacrylamide-co-(2-dimethylamino) ethyl methacrylate)-g-PEG nanoparticle system and its potential in controlled drug release

A. Fassihi, A. Mahdavian, Aylar Najafipour, 2019, Polymer Bulletin.

Pharmacophore Modeling, Synthesis, Scaffold hopping And Biological β-Hematin Inhibition Interaction Studies for Anti-malaria Compounds.

Jahan B. Ghasemi, A. Fassihi, S. Esmaeili, 2019, Current topics in medicinal chemistry.

Prediction of partition coefficient of some 3-hydroxy pyridine-4-one derivatives using combined partial least square regression and genetic algorithm

M. Shahlaei, A. Fassihi, L. Saghaie, 2014, Research in pharmaceutical sciences.

HIV‐1 Entry Inhibitors: A Review of Experimental and Computational Studies

A. Fassihi, L. Saghaie, Tahereh Mostashari Rad, 2018, Chemistry & biodiversity.

Molecular modelling study on pyrrolo[2,3-b]pyridine derivatives as c-Met kinase inhibitors: a combined approach using molecular docking, 3D-QSAR modelling and molecular dynamics simulation

A. Fassihi, Pouria Shirvani, 2020 .

QSAR Study of p56lck Protein Tyrosine Kinase Inhibitory Activity of Flavonoid Derivatives Using MLR and GA-PLS

A. Fassihi, Razieh Sabet, 2008, International journal of molecular sciences.

Recent Advances in the Design and Development of Non‐nucleoside Reverse Transcriptase Inhibitor Scaffolds

A. Fassihi, L. Saghaie, Pouria Shirvani, 2018, ChemMedChem.

Hantzsch-Type dihydropyridines and Biginelli-type tetra-hydropyrimidines: a review of their chemotherapeutic activities.

A. Fassihi, S. Sepehri, H. Sánchez, 2015, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.

QSAR and docking analysis of A2B adenosine receptor antagonists based on non-xanthine scaffold

A. Madadkar-Sobhani, K. Mahnam, A. Fassihi, 2014, Medicinal Chemistry Research.

Linear and nonlinear QSAR modeling of 1,3,8-substituted-9-deazaxanthines as potential selective A2BAR antagonists

A. Madadkar-Sobhani, K. Mahnam, A. Fassihi, 2013, Medicinal Chemistry Research.

QSAR Study of Antimicrobial 3-Hydroxypyridine-4-one and 3-Hydroxypyran-4-one Derivatives Using Different Chemometric Tools

A. Fassihi, Razieh Sabet, 2008, International journal of molecular sciences.

Synthesis and antioxidant evaluation of 4-(furan-2-yl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate esters

A. Fassihi, M. Rostami, A. Movahedian, 2012, Research in pharmaceutical sciences.

Synthesis and antioxidant evaluation of some novel ortho-hydroxypyridine-4-one iron chelators

A. Fassihi, M. Mohammadpour, L. Saghaei, 2012, Research in pharmaceutical sciences.

In silico design of novel FAK inhibitors using integrated molecular docking, 3D-QSAR and molecular dynamics simulation studies

A. Fassihi, Pouria Shirvani, 2021, Journal of biomolecular structure & dynamics.

Structure–activity relationship of polyamine conjugates for uptake via polyamine transport system

A. Fassihi, L. Saghaie, H. Sadeghi-aliabadi, 2018, Structural Chemistry.

Design of a novel metal binding peptide by molecular dynamics simulation to sequester Cu and Zn ions

K. Mahnam, A. Fassihi, A. Mohammadi, 2014, Research in pharmaceutical sciences.

Application of Modern Drug Discovery Techniques in the Context of Diabetes Mellitus and Atherosclerosis

A. Fassihi, A. Bueno-Crespo, H. Pérez‐Sánchez, 2015 .

Design and biological evaluation of phenyl-substituted analogs of beta-phenylethylidenehydrazine.

A. Fassihi, G. Baker, A. Davood, 2005, Bioorganic & medicinal chemistry.

QSAR study of isatin analogues as in vitro anti-cancer agents.

A. Fassihi, M. Mohammadpour, Razieh Sabet, 2010, European journal of medicinal chemistry.

QSAR study of PETT derivatives as potent HIV-1 reverse transcriptase inhibitors.

A. Fassihi, Razieh Sabet, B. Moeinifard, 2009, Journal of molecular graphics & modelling.

Synthesis, antimicrobial evaluation and QSAR study of some 3-hydroxypyridine-4-one and 3-hydroxypyran-4-one derivatives.

A. Fassihi, L. Saghaie, D. Abedi, 2009, European journal of medicinal chemistry.

Quantitative Structure–Activity Relationship Studies on 2‐Amino‐6‐arylsulfonylbenzonitriles as Human Immunodeficiency Viruses Type 1 Reverse Transcriptase Inhibitors Using Descriptors Obtained from Substituents and Whole Molecular Structures

A. Fassihi, B. Hemmateenejad, Razieh Sabet, 2009, Chemical biology & drug design.

Preparation of budesonide–dextran conjugates using glutarate spacer as a colon-targeted drug delivery system: in vitro/in vivo evaluation in induced ulcerative colitis

P. Mahzouni, A. Fassihi, J. Emami, 2011, Journal of drug targeting.

Study of CXCR4 chemokine receptor inhibitors using QSPR and molecular docking methodologies

A. Fassihi, R. Arian, F. Ghasemi, 2019, Journal of Theoretical and Computational Chemistry.

Insights into the human A1 adenosine receptor from molecular dynamics simulation: structural study in the presence of lipid membrane

A. Madadkar-Sobhani, K. Mahnam, A. Fassihi, 2015, Medicinal Chemistry Research.

Identification of Novel 3-Hydroxy-pyran-4-One Derivatives as Potent HIV-1 Integrase Inhibitors Using in silico Structure-Based Combinatorial Library Design Approach

A. Fassihi, L. Saghaie, Simone Brogi, 2019, Front. Chem..

N-Propynyl analogs of beta-phenylethylidenehydrazines: synthesis and evaluation of effects on glycine, GABA, and monoamine oxidase.

A. Fassihi, G. Baker, E. Mackenzie, 2008, Bioorganic & medicinal chemistry.

Linear and nonlinear QSAR modeling of 1,3,8-substituted-9-deazaxanthines as potential selective A2BAR antagonists

A. Madadkar-Sobhani, K. Mahnam, A. Fassihi, 2013, Medicinal Chemistry Research.

QSAR study of some CCR5 antagonists as anti-HIV agents using radial basis function neural network and general regression neural network on the basis of principal components

M. Shahlaei, A. Madadkar-Sobhani, A. Fassihi, 2012, Medicinal Chemistry Research.

QSAR and docking analysis of A2B adenosine receptor antagonists based on non-xanthine scaffold

A. Madadkar-Sobhani, K. Mahnam, A. Fassihi, 2014, Medicinal Chemistry Research.

QSAR analysis of some 1-(3,3-diphenylpropyl)-piperidinyl amides and ureas as CCR5 inhibitors using genetic algorithm-least square support vector machine

M. Shahlaei, A. Fassihi, 2013, Medicinal Chemistry Research.

Comparative quantitative structure–activity relationship study of some 1-aminocyclopentyl-3-carboxyamides as CCR2 inhibitors using stepwise MLR, FA-MLR, and GA-PLS

M. Shahlaei, A. Madadkar-Sobhani, A. Fassihi, 2010, Medicinal Chemistry Research.

Anti‐HIV‐1 Activity Prediction of Novel Gp41 Inhibitors Using Structure‐Based Virtual Screening and Molecular Dynamics Simulation

A. Fassihi, L. Saghaie, S. Sepehri, 2017, Molecular informatics.

A modeling study of aldehyde inhibitors of human cathepsin K using partial least squares method

M. Shahlaei, A. Fassihi, L. Saghaie, 2011, Research in pharmaceutical sciences.

New thiosemicarbazide-1,2,3-triazole hybrids as potent α-glucosidase inhibitors: Design, synthesis, and biological evaluation

B. Larijani, A. Fassihi, L. Saghaie, 2019, Journal of Molecular Structure.

Cardioprotection Potential of Some Hydroxypyridine Iron Chelators Against H2O2-Induced H9C2 Cell Injury

A. Fassihi, M. Behjati, M. Keshvari, 2017 .

Quantitative structure activities relationships of some 2-mercaptoimidazoles as CCR2 inhibitors using genetic algorithm-artificial neural networks

M. Shahlaei, A. Fassihi, L. Saghaie, 2013, Research in pharmaceutical sciences.

QSAR Analysis for Some Diaryl‐substituted Pyrazoles as CCR2 Inhibitors by GA‐Stepwise MLR

M. Shahlaei, A. Madadkar-Sobhani, A. Fassihi, 2011, Chemical biology & drug design.

Assessment of antibacterial activity of wool fabrics dyed with natural dyes

A. Fassihi, F. Alihosseini, D. Abedi, 2014 .

Design and Synthesis of Novel Cytotoxic Indole‐Thiosemicarbazone Derivatives: Biological Evaluation and Docking Study

Jahan B. Ghasemi, A. Fassihi, L. Saghaie, 2019, Chemistry & biodiversity.

Molecular dynamics simulation and 3D-pharmacophore analysis of new quinoline-based analogues with dual potential against EGFR and VEGFR-2.

Jahan B. Ghasemi, A. Fassihi, S. Esmaeili, 2019, International journal of biological macromolecules.

Anti-cancer, anti-oxidant and molecular docking studies of thiosemicarbazone indole-based derivatives

Jahan B. Ghasemi, A. Fassihi, L. Saghaie, 2019, Research on Chemical Intermediates.

Inhibitory effect and structure–activity relationship of some Biginelli-type pyrimidines against HSV-1

K. Majidzadeh-A, A. Fassihi, R. Zabihollahi, 2013, Medicinal Chemistry Research.

Antimicrobial evaluation of some novel derivatives of 3,4-dihydropyrimidine-2(1H)-one

A. Fassihi, D. Abedi, H. Memarian, 2012, Research in pharmaceutical sciences.

Evaluation of the in vitro antiretroviral potential of some Biginelli-type pyrimidines.

A. Fassihi, R. Zabihollahi, S. M. Sadat, 2012, Acta virologica.

Conformational Properties of Novel 1,2,3,4-Tetrahydro- pyrimidinone (thione) Derivatives: A DFT study

A. Fassihi, L. Saghaie, Sara Rafieepour, 2013 .

Design, Synthesis and Molecular Docking Studies of Some Tetrahydropyrimidine Derivatives as Possible Fascin Inhibitors

A. Fassihi, Amirhosein Kefayat, Ahmad Ghasemi, 2019, Chemistry & biodiversity.

Synthesis and antimicrobial activity of novel derivatives of Biginelli pyrimidines

Mohammad Mahdi Jalali, A. Fassihi, L. Saghaie, 2012, Medicinal Chemistry Research.

Synthesis, calcium-channel blocking activity, and conformational analysis of some novel 1,4-dihydropyridines: application of PM3 and DFT computational methods

K. Mahnam, A. Fassihi, M. Mansourian, 2012, Medicinal Chemistry Research.

Synthesis and antileishmanial activity of antimony (V) complexes of hydroxypyranone and hydroxypyridinone ligands

A. Fassihi, L. Saghaei, Vafa Sheikhmoradi, 2018, Research in pharmaceutical sciences.

Synthesis and tyrosinase inhibitory properties of some novel derivatives of kojic acid

A. Fassihi, L. Saghaie, M. Pourfarzam, 2013, Research in pharmaceutical sciences.

Synthesis, calcium-channel blocking activity, and conformational analysis of some novel 1,4-dihydropyridines: application of PM3 and DFT computational methods

K. Mahnam, A. Fassihi, M. Mansourian, 2012, Medicinal Chemistry Research.

Docking Studies of Some Novel Kojic Acid Derivatives As Possible Tyrosinase Inhibitors

A. Fassihi, M. Pourfarzam, P. Yaghmaei, 2015 .

Synthesis of dialkyl 1,4‐dihydro‐2,6‐dimethylpyridine‐3,5‐dicarboxylates and alkyl 1,4‐dihydro‐2,6‐dimethyl‐3‐nitropyridine‐5‐carboxylates possessing a c‐4 2,4‐dioxo‐1,2,3,4‐tetrahydropyrimidin‐5‐yl (uracil) substituent to determine calcium channel modulation structure‐activity relationships

A. Fassihi, E. Knaus, Carlos A. Velázquez, 2004 .

Synthesis and antitubercular activity of novel 4-substituted imidazolyl-2,6-dimethyl-N3,N5-bisaryl-1,4-dihydropyridine-3,5-dicarboxamides.

A. Fassihi, L. Saghaie, H. Sadeghi-aliabadi, 2009, European journal of medicinal chemistry.

Novel Catechol Derivatives of Arylimidamides as Antileishmanial Agents

A. Fassihi, L. Saghaie, G. Hatam, 2018, Chemistry & biodiversity.

Design, synthesis and anti-HIV-1 evaluation of a series of 5-hydroxypyridine-4-one derivatives as possible integrase inhibitors

A. Fassihi, L. Saghaie, R. Zabihollahi, 2015, Medicinal Chemistry Research.

Synthesis, anti-HIV-1 and antiproliferative evaluation of novel 4-nitroimidazole derivatives combined with 5-hydroxy-4-pyridinone moiety

A. Fassihi, L. Saghaie, Z. Debyser, 2020 .

Synthesis, Molecular Modelling and Biological Studies of 3-hydroxy-pyrane-4-one and 3-hydroxy-pyridine-4-one Derivatives as HIV-1 Integrase Inhibitors.

Zeger Debyser, Afshin Fassihi, Simone Brogi, 2018, Medicinal chemistry (Shariqah (United Arab Emirates)).

Physicochemical, pharmaceutical and biological approaches toward designing optimized and efficient hydrophobically modified chitosan-based polymeric micelles as a nanocarrier system for targeted delivery of anticancer drugs

N. Davies, A. Fassihi, J. Emami, 2013, Journal of drug targeting.

Wound healing by topical application of antioxidant iron chelators: kojic acid and deferiprone

A. Fassihi, M. Behjati, M. Mohammadpour, 2012, International wound journal.

Docking studies of some 5-hydroxypyridine-4-one derivatives: evaluation of integrase and ribonuclease H domain of reverse transcriptase as possible targets for anti-HIV-1 activity

A. Fassihi, L. Saghaie, R. Zabihollahi, 2015, Medicinal Chemistry Research.

Design, synthesis, in silico studies, and antiproliferative evaluations of novel indolin-2-one derivatives containing 3-hydroxy-4-pyridinone fragment.

A. Fassihi, L. Saghaie, Z. Debyser, 2022, Bioorganic & medicinal chemistry letters.

A Comparative DFT Study on the Antioxidant Activity of Some Novel 3‐Hydroxypyridine‐4‐One Derivatives

A. Fassihi, K. Zborowski, M. M. Dehkordi, 2022, Chemistry & biodiversity.

In Silico Approach for Designing Potent Inhibitors against Tyrosinase

A. Fassihi, M. Pourfarzam, P. Yaghmaei, 2015 .

Synthesis and evaluation of dextran-budesonide conjugates as colon specific prodrugs for treatment of ulcerative colitis.

A. Fassihi, J. Emami, J. Varshosaz, 2009, International journal of pharmaceutics.

Effectiveness of budesonide-succinate-dextran conjugate as a novel prodrug of budesonide against acetic acid-induced colitis in rats

P. Mahzouni, A. Fassihi, J. Emami, 2010, International Journal of Colorectal Disease.

Cuminaldehyde as the Major Component of Cuminum cyminum, a Natural Aldehyde with Inhibitory Effect on Alpha-Synuclein Fibrillation and Cytotoxicity.

A. Fassihi, H. Pérez‐Sánchez, F. Pan-Montojo, 2015, Journal of food science.

Synthesis and antiproliferative evaluation of some iron chelators as polyamine transporter targeting agents

A. Fassihi, L. Saghaie, H. Sadeghi-aliabadi, 2019, Canadian Journal of Chemistry.

Preliminary MLR studies of antimicrobial activity of some 3- hydroxypyridine-4-one and 3-hydroxypyran-4-one derivatives

A. Fassihi, Razieh Sabet, B. Moeinifard, 2009 .

Computer-aided design of novel antibacterial 3-hydroxypyridine-4-ones: application of QSAR methods based on the MOLMAP approach

Afshin Fassihi, Maryam Gholami, Bahram Hemmateenejad, 2012, Journal of Computer-Aided Molecular Design.

Iron chelation afforded cardioprotection against H2O2-induced H9C2 cell injury: application of novel 3-hydroxy pyridine-4-one derivatives.

A. Fassihi, L. Saghaie, A. Memarnejadian, 2012, International Journal of Cardiology.

Deep neural network in QSAR studies using deep belief network

Alireza Mehridehnavi, Afshin Fassihi, Horacio Emilio Pérez Sánchez, 2018, Appl. Soft Comput..

Synthesis and comparison of anti-Leishmania major activity of antimony and iron complexes of 3-hydroxypyran-4-one and 3-hydroxypyridine-4-one as bi-dentate ligands

A. Fassihi, L. Saghaie, N. Pestechian, 2020 .

Preparation of some novel imidazopyridine derivatives of indole as anticancer agents: one-pot multicomponent synthesis, biological evaluation and docking studies

B. Larijani, A. Fassihi, L. Saghaie, 2019, Research on Chemical Intermediates.

Application of an expert system based on Genetic Algorithm-Adaptive Neuro-Fuzzy Inference System (GA-ANFIS) in QSAR of cathepsin K inhibitors

Afshin Fassihi, Lotfollah Saghaie, Mohsen Shahlaei, 2012, Expert Syst. Appl..

MTX-Loaded Dual Thermoresponsive and pH-Responsive Magnetic Hydrogel Nanocomposite Particles for Combined Controlled Drug Delivery and Hyperthermia Therapy of Cancer.

A. Fassihi, H. Sadeghi-aliabadi, A. Mahdavian, 2020, Molecular pharmaceutics.

Alternating Magnetic Field and Ultrasound Waves as Size Controlling Parameters in Preparation of Superparamagnetic Fe₃O₄ Nanoparticles.

A. Fassihi, A. Mahdavian, H. S. Aliabadi, 2020, Journal of nanoscience and nanotechnology.

Comparative studies on the inhibitory activities of selected benzoic acid derivatives against secretory phospholipase A2, a key enzyme involved in the inflammatory pathway.

A. Fassihi, C. Sadasivan, H. Pérez‐Sánchez, 2015, Molecular bioSystems.

QSAR study of some 5-methyl/trifluoromethoxy- 1H-indole-2,3-dione-3-thiosemicarbazone derivatives as anti-tubercular agents

M. Shahlaei, A. Fassihi, A. Nezami, 2009, Research in pharmaceutical sciences.

Statistically validated QSAR study of some antagonists of the human CCR5 receptor using least square support vector machine based on the genetic algorithm and factor analysis

A. Fassihi, E. Arkan, Mohsen Shahlaie, 2013, Medicinal Chemistry Research.

Acceleration of MPI mechanisms for sustainable HPC applications

Florin Isaila, Alexey Lastovetsky, Horacio Pérez-Sánchez, 2015, Supercomput. Front. Innov..

Accelerating Big Data Quantitative Structure-Activity Prediction through LASSO-Random Forest Algorithm.

A. Fassihi, H. Pérez‐Sánchez, F. Ghasemi, 2021, Bioinformatics.

Poly[N-(2-aminoethyl)ethyleneimine] as a new non-viral gene delivery carrier: the effect of two protonatable nitrogens in the monomer unit on gene delivery efficiency.

C. van Nostrum, W. Hennink, A. Fassihi, 2014, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.

Elucidation of Molecular Mechanisms Behind the Self-Assembly Behavior of Chitosan Amphiphilic Derivatives Through Experiment and Molecular Modeling

K. Mahnam, A. Fassihi, F. Dorkoosh, 2015, Pharmaceutical Research.

Protein kinase inhibitors' classification using K-Nearest neighbor algorithm

Roya Arian, Amirali Hariri, Alireza Mehridehnavi, 2020, Comput. Biol. Chem..

The role of different sampling methods in improving biological activity prediction using deep belief network

Afshin Fassihi, Fahimeh Ghasemi, Horacio Emilio Pérez Sánchez, 2017, J. Comput. Chem..

Synthesis and evaluation of antioxidant activity of some novel hydroxypyridinone derivatives: a DFT approach for explanation of their radical scavenging activity

A. Fassihi, M. Mohammadpour, L. Saghaie, 2020, Research in pharmaceutical sciences.

Elucidation of Molecular Mechanisms Behind the Self-Assembly Behavior of Chitosan Amphiphilic Derivatives Through Experiment and Molecular Modeling

K. Mahnam, A. Fassihi, F. Dorkoosh, 2015, Pharmaceutical Research.

Design, Synthesis, and Anti‐HIV‐1 Evaluation of a Novel Series of 1,2,3,4‐Tetrahydropyrimidine‐5‐Carboxylic Acid Derivatives

A. Fassihi, L. Saghaie, R. Zabihollahi, 2018, Chemistry & biodiversity.