J. Rathmell

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The tumor microenvironment as a metabolic barrier to effector T cells and immunotherapy

A. Lim, W. Rathmell, J. Rathmell, 2020, eLife.

J. Rathmell, R. Michalek, 2008, Molecular cell.

Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival

J. Rathmell, J. L. Coloff, S. R. Jacobs, 2008, Journal of leukocyte biology.

Cytotoxic T Lymphocyte Antigen 4 (CTLA4) Blockade Accelerates the Acute Rejection of Cardiac Allografts in CD28-deficient Mice: CTLA4 Can Function Independently of CD28

C. Thompson, J. Rathmell, G. Gray, 1998, The Journal of experimental medicine.

Anabolism-Associated Mitochondrial Stasis Driving Lymphocyte Differentiation over Self-Renewal.

U. Klein, M. Busslinger, H. Snoeck, 2016, Cell reports.

Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells.

S. Manalis, M. V. Vander Heiden, J. Rathmell, 2016, Developmental cell.

A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product.

Neel S Madhukar, Neel S. Madhukar, O. Elemento, 2017, Cell metabolism.

ACSS2 Regulates HIF-2α Degradation through the E3-Ubiquitin Ligase MUL1 in Clear Cell Renal Cell Carcinoma

W. Rathmell, J. Rathmell, E. Krystofiak, 2022, bioRxiv.

Distinct IL-2 Receptor Signaling Pattern in CD4+CD25+ Regulatory T Cells1

M. Farrar, M. Carroll, C. Thompson, 2004, The Journal of Immunology.

High-fat diet–induced colonocyte dysfunction escalates microbiota-derived trimethylamine N-oxide

Brian J. Bennett, B. Bennett, J. Rathmell, 2021, Science.

Myeloid Slc2a1-Deficient Murine Model Revealed Macrophage Activation and Metabolic Phenotype Are Fueled by GLUT1

Brian J. Bennett, Ashley M. Fuller, J. Locasale, 2019, The Journal of Immunology.

M. Dwyer, W. Zuercher, V. Giguère, 2011, Proceedings of the National Academy of Sciences.

Repression of B7.2 on Self-reactive B Cells Is Essential to Prevent Proliferation and Allow Fas-mediated Deletion by CD4+ T Cells

J. Allison, C. Goodnow, J. Rathmell, 1998, The Journal of experimental medicine.

CD4 T cells differentially express cellular machinery for serotonin signaling, synthesis, and metabolism.

J. Rathmell, Nancie J. MacIver, V. Gerriets, 2020, International immunopharmacology.

Filling a GAP(DH) in Caspase-Independent Cell Death

J. Rathmell, S. Kornbluth, 2007, Cell.

Targeting Metabolism to Improve the Tumor Microenvironment for Cancer Immunotherapy.

J. Rathmell, Kelsey Voss, J. Bader, 2020, Molecular cell.

Glucose metabolism as a target of histone deacetylase inhibitors.

O. Ilkayeva, C. Newgard, J. Rathmell, 2009, Molecular endocrinology.

Miura Development Apoptotic and Nonapoptotic Caspase Functions in Animal

J. Altman, J. Rathmell, R. Nixon, 2012 .

Computational Immune Monitoring Reveals Abnormal Double-Negative T Cells Present across Human Tumor Types

Douglas B. Johnson, A. Greenplate, J. Irish, 2018, Cancer Immunology Research.

Isoform-specific requirement for Akt1 in the developmental regulation of cellular metabolism during lactation.

Katherine D Dugan, L. Chodosh, M. Birnbaum, 2006, Cell metabolism.

Fluorescence-based measurement of cystine uptake through xCT shows requirement for ROS detoxification in activated lymphocytes.

P. Massion, J. Chi, J. Rathmell, 2016, Journal of immunological methods.

ER stress modulates cellular metabolism.

J. Rathmell, Chi Li, B. Altman, 2011, The Biochemical journal.

Obesity, Immunity, and Cancer.

J. Rathmell, 2021, The New England journal of medicine.

Activated lymphocytes as a metabolic model for carcinogenesis

J. Rathmell, A. Macintyre, 2013, Cancer & Metabolism.

Sweet nothings: sensing of sugar metabolites controls T cell function.

D. Green, J. Rathmell, 2013, Cell metabolism.

Stimulating TAM-mediated anti-tumor immunity with mannose-decorated nanoparticles in ovarian cancer

Andrew J. Wilson, W. Rathmell, J. Rathmell, 2022, BMC cancer.

Molecular and Cellular Pathobiology the C-jun Nh 2 -terminal Kinase 2 Plays a Dominant Role in Human Epidermal Neoplasia

Jennifer Y. Zhang, J. Rathmell, J. L. Coloff, 2022 .

Matched and mismatched metabolic fuels in lymphocyte function.

J. Rathmell, A. Caro-Maldonado, V. Gerriets, 2012, Seminars in immunology.

Retinoic acid signaling acts as a rheostat to balance Treg function

S. Furlan, D. Munn, H. Chi, 2022, Cellular & Molecular Immunology.

Mechanisms of self-tolerance and autoimmunity: from whole-animal phenotypes to molecular pathways.

L. Miosge, C. Goodnow, D. Mack, 1999, Cold Spring Harbor symposia on quantitative biology.

Cytotoxic T Lymphocyte Antigen 4 ( CTLA 4 ) Blockade Accelerates the Acute Rejection of Cardiac Allografts in CD 28-deficient Mice : CTLA 4 Can Function Independently of CD 28 By

C. Thompson, J. Rathmell, G. Gray, 1998 .

Effects of the lpr mutation on elimination and inactivation of self-reactive B cells.

C. Goodnow, J. Rathmell, 1994, Journal of immunology.

Asymmetric PI3K Activity in Lymphocytes Organized by a PI3K-Mediated Polarity Pathway

J. Rathmell, R. Kratchmarov, William C. Adams, 2018, Cell reports.

Asymmetric PI3K Activity in Lymphocytes Organized by a PI3K-Mediated Polarity Pathway

J. Rathmell, R. Kratchmarov, William C. Adams, 2018, Cell reports.

Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis

W. Zong, C. Thompson, Ryan M. Cinalli, 2002, Nature Immunology.

IgG-Immune Complexes Promote B Cell Memory by Inducing BAFF

J. Rathmell, B. Vilen, A. Caro-Maldonado, 2016, The Journal of Immunology.

Akt-Dependent and Independent Pathways Activation and Requires CD28-Mediated Glucose Uptake Is Limiting in T Cell

J. Rathmell, S. R. Jacobs, Nancie J. MacIver, 2013 .

A Glucose-to-Gene Link

C. Newgard, J. Rathmell, 2009, Science.

Akt1 and Akt2 are required for αβ thymocyte survival and differentiation

M. Birnbaum, J. Rathmell, M. Juntilla, 2007, Proceedings of the National Academy of Sciences.

Akt and mTOR pathways differentially regulate the development of natural and inducible TH17 cells

M. Birnbaum, J. Rathmell, B. Krock, 2013, Nature Immunology.

Natural and inducible TH17 cells are regulated differently by Akt and mTOR pathways

M. Birnbaum, J. Rathmell, B. Krock, 2013, Nature Immunology.

Akt1 and Akt2 promote peripheral B-cell maturation and survival.

M. Birnbaum, J. Rathmell, M. Juntilla, 2010, Blood.

Metabolismof T Cell Development, Activation, and The Liver Kinase B1 Is a Central Regulator

Takla Griss, Russell G. Jones, J. Rathmell, 2011 .

IL-7 Enhances the Survival and Maintains the Size of Naive T Cells1

C. Thompson, J. Rathmell, Wei Gao, 2001, The Journal of Immunology.

activation of Akt to support T-cell survival IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated

J. Rathmell, S. R. Jacobs, Heather L. Wieman, 2013 .

Autoimmunity: The Fas track

C. Goodnow, J. Rathmell, 1995, Current Biology.

mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation.

Scott A. Brown, H. Chi, J. Locasale, 2016, Immunity.

An essential role for the Glut1 PDZ-binding motif in growth factor regulation of Glut1 degradation and trafficking.

J. Rathmell, S. R. Jacobs, S. Kornbluth, 2009, The Biochemical journal.

Glycogen synthase kinase 3alpha and 3beta mediate a glucose-sensitive antiapoptotic signaling pathway to stabilize Mcl-1.

O. Ilkayeva, J. Rathmell, J. L. Coloff, 2007, Molecular and cellular biology.

Size of Naive T Cells IL-7 Enhances the Survival and Maintains the Thompson

J. Rathmell, E. Farkash, 2001 .

Archetype tasks link intratumoral heterogeneity to plasticity and cancer hallmarks in small cell lung cancer.

Gabor T. Marth, Alissa M. Weaver, G. Marth, 2022, Cell systems.

The Complex Integration of T-cell Metabolism and Immunotherapy.

J. Rathmell, M. Madden, 2021, Cancer discovery.

Akt1 and Akt2 are required for alphabeta thymocyte survival and differentiation.

M. Birnbaum, J. Rathmell, M. Juntilla, 2007, Proceedings of the National Academy of Sciences of the United States of America.

Editorial overview: Metabolism of T cells: integrating nutrients, signals, and cell fate.

J. Rathmell, Nancie J. MacIver, N. MacIver, 2017, Current opinion in immunology.

T cell homeostasis requires G protein‐coupled receptor‐mediated access to trophic signals that promote growth and inhibit chemotaxis

C. Thompson, Ryan M. Cinalli, J. Rathmell, 2005, European journal of immunology.

Integrative computational immunogenomic profiling of cortisol‐secreting adrenocortical carcinoma

W. Rathmell, J. Rathmell, K. Sekhar, 2021, Journal of cellular and molecular medicine.

Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release

J. Rathmell, K. Ravichandran, N. Leitinger, 2018, Nature.

Targeting Glycolysis in Alloreactive T Cells to Prevent Acute Graft-Versus-Host Disease While Preserving Graft-Versus-Leukemia Effect

Chuan-Yuan Li, J. Rathmell, Ying Huang, 2022, Frontiers in Immunology.

IL-7 Is Essential for Homeostatic Control of T Cell Metabolism In Vivo

J. Rathmell, S. R. Jacobs, R. Michalek, 2010, The Journal of Immunology.

This information is current as T Cell Metabolism In Vivo IL-7 Is Essential for Homeostatic Control of

J. Rathmell, S. R. Jacobs, R. Michalek, 2010 .

Pharmacological Blockade of ASCT2-dependent Glutamine Transport Leads To Anti-tumor Efficacy in Preclinical Models

Joe T. Sharick, J. Berlin, M. Washington, 2017, Nature Medicine.

mTORC 1 and mTORC 2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation

H. Chi, J. Locasale, G. Neale, 2016 .

Uropathogenic Escherichia coli subverts mitochondrial metabolism to enable intracellular bacterial pathogenesis in urinary tract infection

W. Chazin, W. Rathmell, J. Rathmell, 2022, Nature Microbiology.

Intestinal Inflammation Promotes MDL-1+ Osteoclast Precursor Expansion to Trigger Osteoclastogenesis and Bone Loss

Joshua R. Johnson, J. Rathmell, J. Cassat, 2022, Cellular and molecular gastroenterology and hepatology.

Low-Salt Diet Reduces Anti-CTLA4 Mediated Systemic Immune-Related Adverse Events while Retaining Therapeutic Efficacy against Breast Cancer

J. Rathmell, J. Titze, V. Tiriveedhi, 2022, Biology.

Lymphocyte selection by starvation: glucose metabolism and cell death.

J. Rathmell, S. R. Jacobs, S. Jacobs, 2006, Trends in immunology.

Engineering a BCR-ABL–activated caspase for the selective elimination of leukemic cells

M. Deininger, J. Rathmell, M. Kurokawa, 2013, Proceedings of the National Academy of Sciences.

Single-cell profiling of the antigen-specific response to BNT162b2 SARS-CoV-2 RNA vaccine

Sierra M. Barone, I. Georgiev, J. Crowe, 2022, Nature Communications.

Droplet Microfluidic Technology for the Early and Label-Free Isolation of Highly-Glycolytic, Activated T-Cells

J. Rathmell, P. Abbyad, C. Zielke, 2022, Micromachines.

Glycolysis-dependent histone deacetylase 4 degradation regulates inflammatory cytokine production

J. Chi, Chun‐Hsiang Lai, T. Yao, 2014, Molecular biology of the cell.

TGF-beta: a new role for an old AktTOR.

J. Rathmell, Pankuri Goraksha-Hicks, 2009, Developmental cell.

Regulation of mitochondrial morphology by APC/CCdh1-mediated control of Drp1 stability

O. Ilkayeva, C. Newgard, J. Rathmell, 2011, Molecular biology of the cell.

Selective glutamine metabolism inhibition in tumor cells improves anti-tumor T lymphocyte activity in triple-negative breast cancer.

J. Rathmell, Shan Wang, Jin Chen, 2020, The Journal of clinical investigation.

Metabolic regulation of T lymphocytes.

J. Rathmell, R. Michalek, Nancie J. MacIver, 2013, Annual review of immunology.

PKCs Sweeten Cell Metabolism by Phosphorylation of Glut1.

J. Rathmell, P. Siska, Peter J. Siska, 2015, Molecular cell.

Cell for Effector and Regulatory CD4 Oxidative Metabolic Programs Are Essential Cutting Edge: Distinct Glycolytic and Lipid

J. Rathmell, S. R. Jacobs, R. Michalek, 2011 .

The in vivo balance between B cell clonal expansion and elimination is regulated by CD95 both on B cells and in their micro‐environment

C. Goodnow, J. Rathmell, 1998, Immunology and cell biology.

Single cell analysis of cribriform prostate cancer reveals cell intrinsic and tumor microenvironmental pathways of aggressive disease

S. Herrell, D. Penson, B. Park, 2022, Nature Communications.

Cytotoxic T cells speci�c for alpha-myosin drive immunotherapy related myocarditis

S. Mallal, M. Carroll, Douglas B. Johnson, 2022 .

T cell Myc-tabolism.

J. Rathmell, 2011, Immunity.

Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets

J. Rathmell, S. R. Jacobs, R. Michalek, 2011, The Journal of Immunology.

Repression of B 7 . 2 on Self-reactive B Cells Is Essential to Prevent Proliferation and Allow Fas-mediated Deletion by CD 4 1 T Cells

J. Allison, C. Goodnow, J. Rathmell, 1998 .

T cell-mediated elimination of B7.2 transgenic B cells.

J. Allison, C. Goodnow, J. Rathmell, 1997, Immunity.

BAFF Promotes Heightened BCR Responsiveness and Manifestations of Chronic GVHD after Allogeneic Stem Cell Transplantation.

J. Rathmell, D. Saban, N. Chao, 2021, Blood.

SnapShot: Immunometabolism.

E. Pearce, J. Rathmell, P. Murray, 2015, Cell metabolism.

Chapter 9 The Bax-1-Bak-l - Mouse: a Model for Apoptosis

J. Golden, W. Zong, J. Rathmell, 2003 .

The Bax-/-Bak-/- Mouse: a Model for Apoptosis

J. Golden, W. Zong, J. Rathmell, 2003 .

Cell Death Pathways in Toxicological Response

J. Rathmell, J. Andersen, 2015 .

Retraction: Natural and inducible TH17 cells are regulated differently by Akt and mTOR pathways

M. Birnbaum, J. Rathmell, B. Krock, 2014, Nature Immunology.

T cells specific for α-myosin drive immunotherapy-related myocarditis

S. Mallal, M. Carroll, Douglas B. Johnson, 2022, Nature.

AIF Is "Always In Fashion" for T Cells.

J. Rathmell, Marc O. Johnson, 2016, Immunity.

Mitochondrial Homeostasis in AML and Gasping for Response in Resistance to BCL2 Blockade.

J. Rathmell, M. Savona, 2019, Cancer discovery.

Metabolic reprogramming of the immune response in the tumor microenvironment

E. Pearce, J. Rathmell, T. Howcroft, 2013, Cancer biology & therapy.

ACSS2 Regulates HIF-2α Degradation through the E3-Ubiquitin Ligase MUL1 in Clear Cell Renal Cell Carcinoma

J. Rathmell, E. Krystofiak, K. Beckermann, 2022, bioRxiv.

Neutrophil trafficking to the site of infection requires Cpt1a-dependent fatty acid β-oxidation

D. Flaherty, J. Rathmell, K. Boyd, 2022, Communications biology.

PD-1 is induced on tumor-associated macrophages in obesity to directly restrain anti-tumor immunity

Emma S. Hathaway, W. Rathmell, J. Rathmell, 2022, bioRxiv.

Cell metabolism: an essential link between cell growth and apoptosis.

J. Rathmell, Jeffrey C Rathmell, Emily F Mason, 2011, Biochimica et biophysica acta.

The psalms of Sir Philip Sidney and the countess of pembroke

J. Rathmell, 1963 .

Jonson, Lord Lisle, and Penshurst

J. Rathmell, 1971, English Literary Renaissance.

Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses

J. Locasale, S. Feske, S. Kaech, 2015, Cell.

MYC and MCL1 Cooperatively Promote Chemotherapy-Resistant Breast Cancer Stem Cells via Regulation of Mitochondrial Oxidative Phosphorylation.

S. Fesik, H. Gómez, K. Hutchinson, 2017, Cell metabolism.

The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues.

S. Korsmeyer, J. Golden, G. Evan, 2000, Molecular cell.

Akt Requires Glucose Metabolism to Suppress Puma Expression and Prevent Apoptosis of Leukemic T Cells*

O. Ilkayeva, G. Zambetti, J. Rathmell, 2010, The Journal of Biological Chemistry.

Designing a broad-spectrum integrative approach for cancer prevention and treatment.

Gloria S. Huang, Rob J. Kulathinal, C. Smythe, 2015, Seminars in cancer biology.

Metabolic Reprogramming Is Required for Antibody Production That Is Suppressed in Anergic but Exaggerated in Chronically BAFF-Exposed B Cells

D. Green, G. Kelsoe, J. Rathmell, 2014, The Journal of Immunology.

Hedgehog Signaling Regulates Metabolism and Polarization of Mammary Tumor-Associated Macrophages

S. Ballinger, J. Rathmell, Atul Kumar, 2021, Cancer Research.

A guide to immunometabolism for immunologists

J. Rathmell, L. O’Neill, R. Kishton, 2016, Nature Reviews Immunology.

Activated lymphocytes as a metabolic model for carcinogenesis

J. Rathmell, A. Macintyre, 2013, Cancer & metabolism.

Metabolic pathways in T cell fate and function.

J. Rathmell, V. Gerriets, 2012, Trends in immunology.

The Liver Kinase B1 Is a Central Regulator of T Cell Development, Activation, and Metabolism

Takla Griss, Russell G. Jones, J. Rathmell, 2011, The Journal of Immunology.

Aerobic glycolysis suppresses p53 activity to provide selective protection from apoptosis upon loss of growth signals or inhibition of BCR-Abl.

J. Rathmell, J. L. Coloff, Hugh S. Gannon, 2010, Cancer research.

Glucose Metabolism Attenuates p53 and Puma-dependent Cell Death upon Growth Factor Deprivation*

J. Rathmell, J. L. Coloff, Kai Cui, 2008, Journal of Biological Chemistry.

Glucose Uptake Is Limiting in T Cell Activation and Requires CD28-Mediated Akt-Dependent and Independent Pathways1

J. Rathmell, Nancie J. MacIver, Heather L. Wieman, 2008, The Journal of Immunology.

IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival.

J. Rathmell, Heather L. Wieman, J. Wofford, 2008, Blood.

Akt-Directed Glucose Metabolism Can Prevent Bax Conformation Change and Promote Growth Factor-Independent Survival

P. Hammerman, C. Thompson, D. Plas, 2003, Molecular and Cellular Biology.

Activated Akt promotes increased resting T cell size, CD28‐independent T cell growth, and development of autoimmunity and lymphoma

C. Thompson, R. Elstrom, Ryan M. Cinalli, 2003, European journal of immunology.

The CD28 signaling pathway regulates glucose metabolism.

C. Thompson, C. June, R. Elstrom, 2002, Immunity.

Homeostatic control of lymphocyte survival: potential origins and implications

C. Thompson, D. Plas, J. Rathmell, 2002, Nature Immunology.

Growth Factors Can Influence Cell Growth and Survival through Effects on Glucose Metabolism

David R. Plas, Craig B. Thompson, M. V. Vander Heiden, 2001, Molecular and Cellular Biology.

In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability.

M. V. Vander Heiden, C. Thompson, M. H. Harris, 2000, Molecular cell.

Akt-dependent glucose metabolism promotes Mcl-1 synthesis to maintain cell survival and resistance to Bcl-2 inhibition.

D. Plas, J. Rathmell, J. L. Coloff, 2011, Cancer research.

Metabolic programming and immune suppression in the tumor microenvironment.

J. Rathmell, Emily N. Arner, 2023, Cancer cell.

T cell metabolic fitness in antitumor immunity.

J. Rathmell, Peter J. Siska, 2015, Trends in immunology.

Dysregulated metabolism contributes to oncogenesis.

R. Deberardinis, S. Sivanand, M. V. Vander Heiden, 2015, Seminars in cancer biology.

Metabolic Alterations Contribute to Enhanced Inflammatory Cytokine Production in Irgm1-deficient Macrophages*

O. Ilkayeva, J. Rathmell, Nancie J. MacIver, 2017, The Journal of Biological Chemistry.

Metabolic changes in Irgm 1-deficient macrophages 1 Metabolic alterations contribute to enhanced inflammatory cytokine production in Irgm 1-deficient macrophages

O. Ilkayeva, J. Rathmell, Nancie J. MacIver, 2017 .

Metabolic stress in autophagy and cell death pathways.

J. Rathmell, B. Altman, 2012, Cold Spring Harbor perspectives in biology.

Autophagy is Essential to Suppress Cell Stress and to Allow BCR-Abl-Mediated Leukemogenesis

O. Ilkayeva, J. Rathmell, You-Wen He, 2010, Oncogene.

Autophagy provides nutrients but can lead to Chop-dependent induction of Bim to sensitize growth factor-deprived cells to apoptosis.

O. Ilkayeva, J. Rathmell, J. L. Coloff, 2009, Molecular biology of the cell.

Leptin Metabolically Licenses T Cells for Activation To Link Nutrition and Immunity

J. Rathmell, Nancie J. MacIver, Donte C. Saucillo, 2014, The Journal of Immunology.

Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression

M. Warmoes, J. Locasale, J. Rathmell, 2016, Nature Immunology.

Suppression of Glut1 and Glucose Metabolism by Decreased Akt/mTORC1 Signaling Drives T Cell Impairment in B Cell Leukemia

G. V. D. van der Windt, A. Kater, J. Rathmell, 2016, The Journal of Immunology.

AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival.

W. Rathmell, M. Warmoes, J. Locasale, 2016, Cell metabolism.

The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function.

J. Rathmell, R. Michalek, S. Anderson, 2014, Cell metabolism.

New roles for pyruvate kinase M2: working out the Warburg effect.

J. Rathmell, Emily C. Ferguson, 2008, Trends in biochemical sciences.

Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking.

J. Rathmell, Heather L. Wieman, J. Wofford, 2007, Molecular biology of the cell.

A guide to interrogating immunometabolism

J. Rathmell, C. Lyssiotis, Kelsey Voss, 2021, Nature Reviews Immunology.

A guide to interrogating immunometabolism

J. Rathmell, C. Lyssiotis, Kelsey Voss, 2021, Nature Reviews Immunology.

Single-cell analysis by mass cytometry reveals metabolic states of early-activated CD8+ T cells during the primary immune response.

M. Spitzer, J. Irish, J. Rathmell, 2021, Immunity.

MiR-215 Is Induced Post-transcriptionally via HIF-Drosha Complex and Mediates Glioma-Initiating Cell Adaptation to Hypoxia by Targeting KDM1B.

R. McLendon, A. Friedman, S. Keir, 2016, Cancer cell.

Metabolic stress is a barrier to Epstein–Barr virus-mediated B-cell immortalization

J. Rathmell, M. Luftig, R. Kishton, 2016, Proceedings of the National Academy of Sciences.

Dysfunctional T cell metabolism in the tumor microenvironment.

J. Rathmell, K. Beckermann, S. Dudzinski, 2017, Cytokine & growth factor reviews.

B‐cell homeostasis: digital survival or analog growth?

J. Rathmell, 2004, Immunological reviews.

Apoptosis and B cell tolerance.

J. Rathmell, 2002, Current directions in autoimmunity.

MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells.

C. Dang, D. Felsher, J. Hogenesch, 2015, Cell Metabolism.

J. Rathmell, G. Andrejeva, 2017, Cell metabolism.

Recent Metabolic Advances for Preventing and Treating Acute and Chronic Graft Versus Host Disease

J. Rathmell, B. Blazar, P. Sage, 2021, Frontiers in Immunology.

The therapeutic implications of immunosuppressive tumor aerobic glycolysis

J. Rathmell, Bradley I. Reinfeld, W. K. Rathmell, 2021, Cellular & Molecular Immunology.

The therapeutic implications of immunosuppressive tumor aerobic glycolysis

W. Rathmell, J. Rathmell, Bradley I. Reinfeld, 2021, Cellular & Molecular Immunology.

Single-cell metabolic dynamics of early activated CD8 T cells during the primary immune response to infection

Kamir J. Hiam, M. Spitzer, J. Rathmell, 2020, bioRxiv.

Single-cell metabolic analysis by mass cytometry reveals distinct transitional states of CD8 T cell differentiation

Kamir J. Hiam, M. Spitzer, J. Rathmell, 2020, The Journal of Immunology.

The Transcription Factor Bhlhe40 Programs Mitochondrial Regulation of Resident CD8+ T Cell Fitness and Functionality.

B. Vincent, M. Kaplan, R. Taneja, 2019, Immunity.

The central effectors of cell death in the immune system.

C. Thompson, J. Rathmell, C. Thompson, 1999, Annual review of immunology.

Immunometabolism: From basic mechanisms to translation

J. Rathmell, L. Makowski, M. Chaib, 2020, Immunological reviews.

Mitochondria, cell death, and B cell tolerance.

J. Rathmell, Paula B Deming, 2006, Current directions in autoimmunity.

Metabolic Regulation of Oocyte Cell Death through the CaMKII-Mediated Phosphorylation of Caspase-2

L. Nutt, M. Jensen, J. Rathmell, 2005, Cell.

Akt and Bcl-xL Are Independent Regulators of the Mitochondrial Cell Death Pathways

C. Thompson, D. Plas, J. Rathmell, 2003 .

Self-tolerance checkpoints in B lymphocyte development.

M. Cooke, J. Cyster, C. Goodnow, 1995, Advances in immunology.

Combined deletion of Glut1 and Glut3 impairs lung adenocarcinoma growth

G. Knott, R. Gruetter, E. Meylan, 2020, eLife.

Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation.

J. Locasale, O. Ilkayeva, C. Newgard, 2015, The Journal of clinical investigation.

CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4+T cells

Mark M. Davis, M. Cooke, C. Goodnow, 1995, Nature.

Metabolic Barriers to T Cell Function in Tumors

J. Rathmell, Ayaka Sugiura, 2018, The Journal of Immunology.

This information is current as Tumors Metabolic Barriers to T Cell Function in

J. Rathmell, Ayaka Sugiura, 2017 .

Acly Deficiency Enhances Myelopoiesis through Acetyl Coenzyme A and Metabolic–Epigenetic Cross-Talk

K. Wellen, J. Rathmell, P. Ferrell, 2022, ImmunoHorizons.

Macrophage-Derived MicroRNA-21 Drives Overwhelming Glycolytic and Inflammatory Response during Sepsis via Repression of the PGE2/IL-10 Axis

J. Rathmell, J. Alves-Filho, C. H. Serezani, 2021, The Journal of Immunology.

Pathways of Apoptosis in Lymphocyte Development, Homeostasis, and Disease

C. Thompson, J. Rathmell, C. Thompson, 2002, Cell.

Mitochondrial dysregulation and glycolytic insufficiency functionally impair CD8 T cells infiltrating human renal cell carcinoma.

W. Rathmell, B. Vincent, A. Greenplate, 2017, JCI insight.

Cell Programmed Nutrient Partitioning in the Tumor Microenvironment

M. V. Heiden, M. V. Vander Heiden, W. Rathmell, 2020, bioRxiv.

Akt and Bcl-xL Promote Growth Factor-independent Survival through Distinct Effects on Mitochondrial Physiology*

C. Thompson, D. Plas, J. Rathmell, 2001, The Journal of Biological Chemistry.

Dysregulation of fatty acid synthesis and glycolysis in non-Hodgkin lymphoma

J. Rathmell, D. Dittmer, B. Damania, 2012, Proceedings of the National Academy of Sciences.

The oxysterol, 27-hydroxycholesterol, links cholesterol metabolism to bone homeostasis through its actions on the estrogen and liver X receptors.

Carolyn D. DuSell, S. Khosla, J. Rathmell, 2011, Endocrinology.

HIF-1 Alpha Regulates the Response of Primary Sarcomas to Radiation Therapy through a Cell Autonomous Mechanism

M. Dewhirst, D. Kirsch, T. Delaney, 2015, Radiation research.

HIF1α and HIF2α Exert Distinct Nutrient Preferences in Renal Cells

W. Rathmell, J. Rathmell, J. L. Coloff, 2014, PloS one.

Cytokine stimulation of aerobic glycolysis in hematopoietic cells exceeds proliferative demand

P. Hammerman, C. Thompson, D. E. Bauer, 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

The Integration of Metabolism and Cell Death

J. Rathmell, J. L. Coloff, Yuxing Zhao, 2009 .

Expansion or Elimination of B Cells In Vivo: Dual Roles for CD40- and Fas (CD95)-Ligands Modulated by the B Cell Antigen Receptor

R. Flavell, C. Goodnow, J. Rathmell, 1996, Cell.

Antigen receptor control of methionine metabolism in T cells

Linda V. Sinclair, A. Lamond, J. Locasale, 2018, bioRxiv.

Clinical Features and Multiplatform Molecular Analysis Assist in Understanding Patient Response to Anti-PD-1/PD-L1 in Renal Cell Carcinoma

Anupama Reddy, J. Kim, W. Rathmell, 2021, Cancers.

BAFF-Exposed B Cells Anergic but Exaggerated in Chronically Antibody Production That Is Suppressed in Metabolic Reprogramming Is Required for Green and

G. Kelsoe, J. Rathmell, S. Milasta, 2014 .

Glycogen Synthase Kinase 3α and 3β Mediate a Glucose-Sensitive Antiapoptotic Signaling Pathway To Stabilize Mcl-1

O. Ilkayeva, J. Rathmell, J. L. Coloff, 2007, Molecular and Cellular Biology.

The metabolic life and times of a T‐cell

J. Rathmell, R. Michalek, Ryan D. Michalek, 2010, Immunological reviews.

xCT (SLC7A11)-mediated metabolic reprogramming promotes non-small cell lung cancer progression

Jamey D. Young, P. Massion, J. Qian, 2018, Oncogene.

GLUT1 Expression in Tumor-Associated Neutrophils Promotes Lung Cancer Growth and Resistance to Radiotherapy

S. Peters, D. Kirsch, E. Meylan, 2021, Cancer Research.

Systematic identification of signaling pathways with potential to confer anticancer drug resistance

Donald P. McDonnell, Tim Wang, Jeff S. Jasper, 2014, Science Signaling.

Metabolic Pathways in Kidney Cancer: Current Therapies and Future Directions.

W. Linehan, W. Rathmell, J. Rathmell, 2018, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Single-Cell Profiling of the Antigen-Specific Response to BNT162b2 SARS-CoV-2 RNA Vaccine

Sierra M. Barone, I. Georgiev, J. Crowe, 2021, bioRxiv.

Multiplatform Integrative Analyses of Immunosuppressive Signatures in Cortisol-secreting Adrenocortical Carcinoma

J. Rathmell, N. Baregamian, David N. Hanna, 2021, bioRxiv.

MRI of tumor T cell infiltration in response to checkpoint inhibitor therapy

J. Gore, E. McKinley, Junzhong Xu, 2020, Journal for immunotherapy of cancer.

Cell Development, Activation, and Metabolism The Liver Kinase B1 Is a Central Regulator of T

Takla Griss, J. Rathmell, Donte C. Saucillo, 2011 .

Deep exploration of the immune infiltrate and outcome prediction in testicular cancer by quantitative multiplexed immunohistochemistry and gene expression profiling

J. Kim, W. Rathmell, J. Bordeaux, 2017, Oncoimmunology.

Subset-specific mitochondrial and DNA damage shapes T cell responses to fever and inflammation

A. Bick, J. Rathmell, C. Lyssiotis, 2022, bioRxiv.

Elevated transferrin receptor impairs T cell metabolism and function in systemic lupus erythematosus

Eric P. Skaar, W. Rathmell, J. Rathmell, 2023, Science Immunology.

Dysregulated Transferrin Receptor Disrupts T Cell Iron Homeostasis to Drive Inflammation in Systemic Lupus Erythematosus

Eric P. Skaar, J. Rathmell, William N. Beavers, 2021, bioRxiv.

Microenvironmental influences on T cell immunity in cancer and inflammation

J. Rathmell, Darren R. Heintzman, Emilie L. Fisher, 2022, Cellular & Molecular Immunology.

Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism

J. Locasale, Pingsheng Wu, W. Rathmell, 2018, Cell.

Functional Overlap of Inborn Errors of Immunity and Metabolism Genes Define T Cell Immunometabolic Vulnerabilities

J. Rathmell, J. Markle, Caroline Bodnya, 2023, bioRxiv.

The Transcription Factor Bhlhe40 Programs Mitochondrial Regulation of Resident CD8+ T Cell Fitness and Functionality.

B. Vincent, M. Kaplan, R. Taneja, 2020, Immunity.

Multiplatform Computational Analysis of Mast Cells in Adrenocortical Carcinoma Tumor Microenvironment

J. Rathmell, K. Sekhar, N. Baregamian, 2021, bioRxiv.

Biochemical Underpinnings of Immune Cell Metabolic Phenotypes

M. V. Vander Heiden, J. Rathmell, B. Olenchock, 2017, Immunity.

Oligodeoxynucleotides ODN 2006 and M362 Exert Potent Adjuvant Effect through TLR-9/-6 Synergy to Exaggerate Mammaglobin-A Peptide Specific Cytotoxic CD8+T Lymphocyte Responses against Breast Cancer Cells

J. Rathmell, R. Zent, V. Tiriveedhi, 2019, Cancers.

Novel Therapeutic Targets of Tumor Metabolism

J. Rathmell, R. Kishton, 2015, Cancer journal.

Impaired enolase 1 glycolytic activity restrains effector functions of tumor-infiltrating CD8+ T cells

C. Slingluff, J. Locasale, J. Rathmell, 2019, Science Immunology.

Chronic lymphocytic leukemia cells impair mitochondrial fitness in CD8+ T cells and impede CAR T cell efficacy.

D. Porter, C. June, J. Melenhorst, 2018, Blood.

Metabolic Signaling Drives IFN-γ.

J. Rathmell, Peter J. Siska, 2016, Cell metabolism.

Nutrients and the microenvironment to feed a T cell army.

J. Rathmell, Marc O. Johnson, Peter J. Siska, 2016, Seminars in immunology.

Metabolic Reprogramming towards Aerobic Glycolysis Correlates with Greater Proliferative Ability and Resistance to Metabolic Inhibition in CD8 versus CD4 T Cells

J. Rathmell, A. Macintyre, Yilin Cao, 2014, PloS one.

What keeps a resting T cell alive?

J. Opferman, M. V. Vander Heiden, C. Thompson, 1999, Cold Spring Harbor symposia on quantitative biology.

MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function.

J. Rabinowitz, J. Rathmell, John Karijolich, 2021, Immunity.

ERRα-Regulated Lactate Metabolism Contributes to Resistance to Targeted Therapies in Breast Cancer.

Jeff S. Jasper, M. Dewhirst, J. Locasale, 2016, Cell reports.

ERRa-Regulated Lactate M etabolism Contributes to Resistance to Targeted Therapies in Breast Cancer

Jeff S. Jasper, M. Dewhirst, J. Locasale, 2016 .

Differential Glucose Requirement in Skin Homeostasis and Injury Identifies a Therapeutic Target for Psoriasis

R. Deberardinis, Marcel Mettlen, J. Rathmell, 2018, Nature Medicine.

CD28 costimulation drives tumor-infiltrating T cell glycolysis to promote inflammation

Sierra M. Barone, W. Rathmell, B. Vincent, 2020, JCI insight.

BET Inhibition Enhances the Antileukemic Activity of Low-dose Venetoclax in Acute Myeloid Leukemia

J. Rathmell, K. Boyd, S. Hiebert, 2020, Clinical Cancer Research.

Recipient-Derived BAFF and Alloantigen Synergistically Activate B Cells in Murine Chronic Gvhd

J. Rathmell, D. Saban, N. Chao, 2016 .

Fine tuning of immunometabolism for the treatment of rheumatic diseases

J. Rathmell, A. Major, J. Rhoads, 2017, Nature Reviews Rheumatology.

Macrophages Promote Aortic Valve Cell Calcification and Alter STAT3 Splicing

J. Rathmell, M. Bersi, M. Madhur, 2020 .

Macrophages Promote Aortic Valve Cell Calcification and Alter STAT3 (Signal Transducer and Activator of Transcription 3) Splicing.

J. Rathmell, M. Bersi, M. Madhur, 2020, Arteriosclerosis, thrombosis, and vascular biology.

Macrophages Promote Aortic Valve Cell Calcification Through STAT3 Splicing

J. Rathmell, M. Bersi, M. Madhur, 2020, bioRxiv.

Glucose Availability and Glycolytic Metabolism Dictate Glycosphingolipid Levels

J. Rathmell, Leah J. Siskind, L. Beverly, 2015, Journal of cellular biochemistry.

MTHFD2 is a Metabolic Checkpoint Controlling Effector and Regulatory T Cell Fate and Function

J. Rabinowitz, J. Rathmell, John Karijolich, 2021, bioRxiv.

Ex Vivo High Salt Activated Tumor-Primed CD4+T Lymphocytes Exert a Potent Anti-Cancer Response

J. Rathmell, J. Titze, R. Zent, 2021, Cancers.

Chronic Lymphocytic Leukemia Cells Impair Mitochondrial Fitness in CD8+ T Cells and Impede CAR T Cell Efficacy

D. Porter, C. June, J. Melenhorst, 2018, Blood.

Immunometabolism at the crossroads of obesity and cancer—a Keystone Symposia report

I. Amit, D. Green, Russell G. Jones, 2023, Annals of the New York Academy of Sciences.

Metabolic regulation of Akt: roles reversed

J. Rathmell, J. L. Coloff, Jonathan L. Coloff, 2006, The Journal of cell biology.

Metabolism and autophagy in the immune system: immunometabolism comes of age

J. Rathmell, 2012, Immunological reviews.

Cancer esearch apeutics , Targets , and Chemical Biology obic Glycolysis Suppresses p 53 Activity to Provide ctive Protection from Apoptosis upon Loss of R wth Signals or Inhibition of BCR-Abl

J. Rathmell, J. L. Coloff, F. Mason, 2010 .

Mechanisms and methods in glucose metabolism and cell death.

J. Rathmell, Heather L. Wieman, Yuxing Zhao, 2008, Methods in enzymology.

Targeting In Vivo Metabolic Vulnerabilities of Th2 and Th17 Cells Reduces Airway Inflammation

Sierra M. Barone, Kellen L. Olszewski, J. Locasale, 2021, The Journal of Immunology.

Anergy into T regulatory cells : an integration of metabolic cues and epigenetic changes at the Foxp 3 conserved non-coding sequence 2

J. Rathmell, 2019 .

The phosphatase PTEN-mediated control of PI-3 kinase in T regs cells maintains homeostasis and lineage stability

J. Bluestone, A. Sharpe, J. Rathmell, 2015 .

PKM2 and the tricky balance of growth and energy in cancer.

J. Rathmell, A. Macintyre, 2011, Molecular cell.

Leptin Augments Antitumor Immunity in Obesity by Repolarizing Tumor-Associated Macrophages

J. Rathmell, Nancie J. MacIver, T. Giorgio, 2021, The Journal of Immunology.

Cardiosphere-Derived Cells Demonstrate Metabolic Flexibility That Is Influenced by Adhesion Status

R. Wahl, B. Tsui, M. Pomper, 2017, JACC. Basic to translational science.

Autophagy: Not good OR bad, but good AND bad

J. Rathmell, B. Altman, 2009, Autophagy.

STAT1 Gain-of-Function Variants Drive Altered T Cell Prevalence, Metabolism, and Heightened IL-6 Sensitivity

J. Rathmell, J. Irish, Madeline J. Hayes, 2021, bioRxiv.

Androgen Signaling Restricts Glutaminolysis to Drive Sex-Specific Th17 Metabolism

J. Rathmell, R. Peebles, D. Newcomb, 2023, bioRxiv.

Neurons require glucose uptake and glycolysis in vivo.

Neal K. Bennett, Yoshitaka J. Sei, M. Zilberter, 2023, Cell reports.

ERα Signaling Increased IL-17A Production in Th17 Cells by Upregulating IL-23R Expression, Mitochondrial Respiration, and Proliferation

Pingsheng Wu, J. Rathmell, D. Newcomb, 2019, Front. Immunol..

Engineering functional 3-dimensional patient-derived endocrine organoids for broad multiplatform applications.

A. Mahadevan-Jansen, J. Rathmell, M. Freeman, 2022, Surgery.

Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release

J. Rathmell, K. Ravichandran, N. Leitinger, 2018, Nature.

Combination immunotherapy and radiotherapy causes an abscopal treatment response in a mouse model of castration resistant prostate cancer

Brent D. Cameron, J. Rathmell, A. Kirschner, 2019, Journal of Immunotherapy for Cancer.

Characterization of metabolic alterations of Chronic Lymphocytic Leukemia in the lymph node microenvironment.

G. V. D. van der Windt, A. Kater, G. Packham, 2022, Blood.

STING-activating nanoparticles normalize the vascular-immune interface to potentiate cancer immunotherapy

J. Balko, J. Rathmell, John T. Wilson, 2023, Science Immunology.

Mutant KRAS Exosomes Alter the Metabolic State of Recipient Colonic Epithelial Cells

Alex J. Walsh, R. Coffey, E. McKinley, 2018, Cellular and molecular gastroenterology and hepatology.

A spontaneous deletion within the desmoglein 3 extracellular domain of mice results in hypomorphic protein expression, immunodeficiency, and a wasting disease phenotype.

J. Rathmell, T. Tedder, J. Poe, 2015, The American journal of pathology.

Transcriptional and metabolic programs promote the expansion of follicular helper T cells in lupus-prone mice

J. Rathmell, L. Morel, Minghao Gong, 2023, iScience.

Multiplatform computational analysis of mast cells in adrenocortical carcinoma tumor microenvironment.

W. Rathmell, J. Rathmell, K. Sekhar, 2021, Surgery.

Cytotoxic T Lymphocyte Antigen 4 (CTLA4) Blockade Accelerates the Acute Rejection of Cardiac Allografts in CD28-deficient Mice: CTLA4 Can Function Independently of CD28

J. Rathmell, G. Gray, J. Leiden, 1998, Journal of Experimental Medicine.

PS1125 LINKING MICROENVIRONMENTAL SIGNALS TO METABOLIC SWITCHES AND IBRUTINIB RESPONSE IN CHRONIC LYMPHOCYTIC LEUKEMIA

A. Kater, J. Rathmell, G. V. D. Windt, 2019, HemaSphere.

Targeting metabolic dysregulation of T cells in kidney cancer.

Sierra M. Barone, W. Rathmell, B. Vincent, 2020 .

Molecular and Cellular Pathobiology the C-jun Nh 2 -terminal Kinase 2 Plays a Dominant Role in Human Epidermal Neoplasia

Jennifer Y. Zhang, J. Rathmell, Hengning Ke, 2022 .

Tissue-Specific Dependence of Th1 Cells on the Amino Acid Transporter SLC38A1 in Inflammation

J. Rathmell, C. Lyssiotis, J. Cephus, 2023, bioRxiv.

Differential Effects of Glutamine Inhibition Strategies on Antitumor CD8 T Cells.

Emma S. Hathaway, J. Rathmell, John Karijolich, 2023, Journal of immunology.

The phosphatase PTEN-mediated control of PI-3 kinase in Tregs cells maintains homeostasis and lineage stability

J. Bluestone, A. Sharpe, J. Rathmell, 2014, Nature Immunology.

T cell metabolic fitness in antitumor immunity.

J. Rathmell, Peter J. Siska, 2015, Trends in immunology.

Designing a broad-spectrum integrative approach for cancer prevention and treatment.

Gloria S. Huang, Rob J. Kulathinal, C. Smythe, 2015, Seminars in cancer biology.

Nutrients and the microenvironment to feed a T cell army.

J. Rathmell, Peter J. Siska, Diana C. Contreras, 2016, Seminars in immunology.

Guidelines for the use and interpretation of assays for monitoring autophagy

Robert Clarke, Hong Jiang, Hiroyuki Ishida, 2012 .

The phosphatase PTEN-mediated control of PI-3 kinase in T regs cells maintains homeostasis and lineage stability

J. Bluestone, A. Sharpe, J. Rathmell, 2015 .

Akt-dependent glucose metabolism promotes Mcl-1 synthesis to maintain cell survival and resistance to Bcl-2 inhibition.

D. Plas, J. Rathmell, A. Macintyre, 2011, Cancer research.

Mitochondrial dysregulation and glycolytic insufficiency functionally impair CD8 T cells infiltrating human renal cell carcinoma.

W. Rathmell, B. Vincent, A. Greenplate, 2017, JCI insight.

Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells.

S. Manalis, M. V. Vander Heiden, J. Rathmell, 2016, Developmental cell.

IL-7 Is Essential for Homeostatic Control of T Cell Metabolism In Vivo

J. Rathmell, S. Jacobs, Ryan D. Michalek, 2010, The Journal of Immunology.

Matched and mismatched metabolic fuels in lymphocyte function.

J. Rathmell, A. Caro-Maldonado, V. Gerriets, 2012, Seminars in immunology.

Glucose Metabolism Attenuates p53 and Puma-dependent Cell Death upon Growth Factor Deprivation*

J. Rathmell, Kai Cui, Yuxing Zhao, 2008, Journal of Biological Chemistry.

Guidelines for the use and interpretation of assays for monitoring autophage

T. P. Neufeld, Thomas J. Begley, H. Coller, 2012 .

Cell-programmed nutrient partitioning in the tumour microenvironment

M. V. Vander Heiden, W. Rathmell, J. Rathmell, 2021, Nature.

Hedgehog Signaling Regulates Treg to Th17 Conversion Through Metabolic Rewiring in Breast Cancer.

J. Rathmell, V. Darley-Usmar, R. Samant, 2023, Cancer immunology research.

MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells.

C. Dang, D. Felsher, J. Hogenesch, 2015, Cell metabolism.

The phosphatase PTEN-mediated control of PI-3 kinase in Tregs cells maintains homeostasis and lineage stability

J. Bluestone, A. Sharpe, J. Rathmell, 2014, Nature Immunology.

T cell Myc-tabolism.

J. Rathmell, 2011, Immunity.

Lipid kinase PIK3C3 maintains healthy brown and white adipose tissues to prevent metabolic diseases

J. Rathmell, Wenqiang Song, Katrina L. Leaptrot, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Connective tissue growth factor (CTGF) inactivation leads to defects in islet cell lineage allocation and beta-cell proliferation during embryogenesis.

A. Murphy, K. Lyons, G. Yancopoulos, 2009, Molecular endocrinology.

Nutrient inputs and social metabolic control of T cell fate.

J. Rathmell, Zachary A. Bacigalupa, Madelyn D. Landis, 2023, Cell metabolism.

Scalable single-cell pooled CRISPR screens with conventional knockout vector libraries

J. Rathmell, Brian C Grieb, Christian de Caestecker, 2024, bioRxiv.

Temporal recording of mammalian development and precancer

Reza Kalhor, M. Shrubsole, A. Simmons, 2023, bioRxiv.

Cell metabolism: an essential link between cell growth and apoptosis.

J. Rathmell, Emily F. Mason, 2011, Biochimica et biophysica acta.