C. Castañeda

发表

Structural Basis for the Inhibitory Effects of Ubistatins in the Ubiquitin-Proteasome Pathway.

R. Deshaies, M. Glickman, D. Fushman, 2017, Structure.

Determinants of electrostatic energies and pKa values in proteins

C. Castañeda, 2009 .

Recovering a representative conformational ensemble from underdetermined macromolecular structural data.

Andrej Sali, Dina Schneidman-Duhovny, Konstantin Berlin, 2013, Journal of the American Chemical Society.

Molecular determinants of the pKa values of Asp and Glu residues in staphylococcal nuclease

C. Castañeda, J. Schlessman, C. A. Fitch, 2009, Proteins.

Structural origins of high apparent dielectric constants experienced by ionizable groups in the hydrophobic core of a protein.

B. García-Moreno E., C. Castañeda, A. Majumdar, 2011, Journal of molecular biology.

High tolerance for ionizable residues in the hydrophobic interior of proteins

B. García-Moreno E., C. Castañeda, Daniel G. Isom, 2008, Proceedings of the National Academy of Sciences.

Charges in the hydrophobic interior of proteins

B. García-Moreno E., C. Castañeda, D. Isom, 2010, Proceedings of the National Academy of Sciences.

The pK(a) values of acidic and basic residues buried at the same internal location in a protein are governed by different factors.

B. García-Moreno E., M. Harms, C. Castañeda, 2009, Journal of molecular biology.

Linkage-specific conformational ensembles of non-canonical polyubiquitin chains.

D. Fushman, C. Castañeda, C. M. Camara, 2016, Physical chemistry chemical physics : PCCP.

Unique structural, dynamical, and functional properties of k11-linked polyubiquitin chains.

D. Fushman, M. Nakasone, C. Castañeda, 2013, Structure.

Unexpected Trypsin Cleavage at Ubiquitinated Lysines

Meghan C. Burke, Meghan C Burke, C. Fenselau, 2015, Analytical chemistry.

Kemp Eliminases of the AlleyCat Family Possess High Substrate Promiscuity

Yurii S. Moroz, O. Makhlynets, I. Korendovych, 2019, ChemCatChem.

Preparing to read the ubiquitin code: a middle-out strategy for characterization of all lysine-linked diubiquitins.

C. Fenselau, D. Fushman, C. Castañeda, 2014, Journal of mass spectrometry : JMS.

Ubiquitin‐Modulated Phase Separation of Shuttle Proteins: Does Condensate Formation Promote Protein Degradation?

C. Castañeda, T. Dao, Thuy P. Dao, 2020, BioEssays : news and reviews in molecular, cellular and developmental biology.

Controlled enzymatic synthesis of natural-linkage, defined-length polyubiquitin chains using lysines with removable protecting groups.

R. Singh, D. Fushman, C. Castañeda, 2011, Chemical communications.

Impact of Climate Variability on the Ecological Components of a Swamp: the Case of Pantanos De Villa, Peru

C. Castañeda, Dagnert L. Naquiche Yesquena, Kenia K. Luna Ayalaa, 2021 .

Single Amino Acid Substitutions in Stickers, but Not Spacers, Substantially Alter UBQLN2 Phase Transitions and Dense Phase Material Properties.

C. Castañeda, T. Dao, Holly B. Jones, 2019, The journal of physical chemistry. B.

Previously uncharacterized interactions between the folded and intrinsically disordered domains impart asymmetric effects on UBQLN2 phase separation

C. Castañeda, Tongyin Zheng, 2021, bioRxiv.

Functional tuning of the catalytic residue pKa in a de novo designed esterase

O. Makhlynets, C. Castañeda, Katharina Hiebler, 2017, Proteins.

Phase separation in biology and disease—a symposium report

Luke E. Berchowitz, Nicolas L. Fawzi, R. Pappu, 2019, Annals of the New York Academy of Sciences.

Modifying the vicinity of the isopeptide bond to reveal differential behavior of ubiquitin chains with interacting proteins: organic chemistry applied to synthetic proteins.

A. Ciechanover, D. Fushman, A. Brik, 2013, Angewandte Chemie.

Mechanistic insights into enhancement or inhibition of phase separation by different polyubiquitin chains

S. Loh, M. Cosgrove, C. Castañeda, 2022, EMBO reports.

ALS-linked mutations impair UBQLN2 stress-induced biomolecular condensate assembly in cells

C. Castañeda, H. Hehnly, Julia F Riley, 2020, bioRxiv.

Large shifts in pKa values of lysine residues buried inside a protein

B. García-Moreno E., C. Castañeda, Daniel G. Isom, 2011, Proceedings of the National Academy of Sciences.

Structure, dynamics and functions of UBQLNs: at the crossroads of protein quality control machinery.

C. Castañeda, Tongyin Zheng, Yiran Yang, 2020, The Biochemical journal.

ALS-Linked Mutations Affect UBQLN2 Oligomerization and Phase Separation in a Position- and Amino Acid-Dependent Manner.

M. Cosgrove, C. Castañeda, H. Hehnly, 2019, Structure.

Ubiquitin Modulates Liquid-Liquid Phase Separation of UBQLN2 via Disruption of Multivalent Interactions.

J. Taylor, C. Castañeda, H. Hehnly, 2018, Molecules and Cells.

Engineered Domain Swapping as an On/Off Switch for Protein Function.

J. Ha, S. Loh, C. Castañeda, 2015, Chemistry & biology.

Structure analysis suggests Ess1 isomerizes the carboxy-terminal domain of RNA polymerase II via a bivalent anchoring mechanism

M. Cosgrove, C. Castañeda, S. Hanes, 2021, Communications biology.

Decoding optimal ligand design for multicomponent condensates

C. Castañeda, J. Schmit, Sarasi K. K. Galagedera, 2023, bioRxiv.

Mechanistic insights into the enhancement or inhibition of phase separation by polyubiquitin chains of different lengths or linkages

S. Loh, M. Cosgrove, C. Castañeda, 2021, bioRxiv.

Alanine scan of core positions in ubiquitin reveals links between dynamics, stability, and function.

D. Bolon, D. Fushman, C. Castañeda, 2014, Journal of molecular biology.

Evidence for Cooperative and Domain-specific Binding of the Signal Transducing Adaptor Molecule 2 (STAM2) to Lys63-linked Diubiquitin*

D. Fushman, Daniela Hoeller, O. Walker, 2012, The Journal of Biological Chemistry.

Structural and thermodynamic consequences of burial of an artificial ion pair in the hydrophobic interior of a protein

B. García-Moreno E., C. Castañeda, J. Schlessman, 2014, Proceedings of the National Academy of Sciences.

Base-CP proteasome can serve as a platform for stepwise lid formation

M. Glickman, D. Fushman, N. Reis, 2015, Bioscience reports.

Nonenzymatic assembly of branched polyubiquitin chains for structural and biochemical studies.

D. Fushman, C. Castañeda, Yan Wang, 2013, Bioorganic & medicinal chemistry.

Linkage via K27 Bestows Ubiquitin Chains with Unique Properties among Polyubiquitins.

D. Fushman, M. Nakasone, O. Walker, 2016, Structure.

ALS‐linked mutations impair UBQLN2 stress‐induced biomolecular condensate assembly in cells

C. Castañeda, H. Hehnly, Julia F Riley, 2021, Journal of neurochemistry.

DNA-damage-inducible 1 protein (Ddi1) contains an uncharacteristic ubiquitin-like domain that binds ubiquitin.

M. Glickman, D. Fushman, N. Reis, 2015, Structure.

Nonenzymatic assembly of natural polyubiquitin chains of any linkage composition and isotopic labeling scheme.

D. Fushman, C. Castañeda, U. Nowicka, 2011, Journal of the American Chemical Society.

Segmental isotopic labeling of ubiquitin chains to unravel monomer-specific molecular behavior.

D. Fushman, A. Brik, C. Castañeda, 2011, Angewandte Chemie.

Decoding optimal ligand design for multicomponent condensates

C. Castañeda, J. Schmit, Sarasi K. K. Galagedera, 2023, bioRxiv.

Direct evidence for deprotonation of a lysine side chain buried in the hydrophobic core of a protein.

Michael Chimenti, C. Castañeda, B. García-Moreno, 2008, Journal of the American Chemical Society.

We con-dense if we want to; We can't leave AZUL outside.

C. Castañeda, Thuy P. Dao, 2023, Structure.

Functional tuning of the catalytic residue pKa in a de novo designed esterase

O. Makhlynets, C. Castañeda, Katharina Hiebler, 2017, Proteins.

DNA-Damage-Inducible 1 Protein ( Ddi 1 ) Contains an Uncharacteristic Ubiquitin-like Domain that Binds Ubiquitin Highlights

M. Glickman, D. Fushman, O. Walker, 2015 .

Ion Mobility Mass Spectrometry Unveils Global Protein Conformations in Response to Conditions that Promote and Reverse Liquid–Liquid Phase Separation

C. Castañeda, J. Ujma, Thuy P. Dao, 2023, bioRxiv.

Cancer Mutations in SPOP Put a Stop to Its Inter-compartmental Hops.

C. Castañeda, Julia F Riley, Thuy P. Dao, 2018, Molecular cell.