A. Wiederkehr

发表

Oxidative stress and calcium dysregulation by palmitate in type 2 diabetes

L. Ly, Shanhua Xu, Seong-Kyung Choi, 2017, Experimental &Molecular Medicine.

Illuminating redox biology using NADH- and NADPH-specific sensors

A. Wiederkehr, N. Demaurex, 2017, Nature Methods.

The Human Diabetes Proteome Project (HDPP): From network biology to targets for therapies and prevention

Ioannis Xenarios, Anne Zufferey, F. Topf, 2013 .

Medium‐chain fatty acids inhibit mitochondrial metabolism in astrocytes promoting astrocyte‐neuron lactate and ketone body shuttle systems

Gregory Lefebvre, A. Wiederkehr, K. Sakamoto, 2016, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Mitochondrial matrix pH controls oxidative phosphorylation and metabolism‐secretion coupling in INS‐1E clonal β cells

P. Rorsman, T. Pozzan, A. Wiederkehr, 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Matrix alkalinization: a novel mitochondrial signal for sustained pancreatic β‐cell activation

T. Pozzan, G. Cline, A. Wiederkehr, 2009, The EMBO journal.

Selective Actions of Mitochondrial Fission/Fusion Genes on Metabolism-Secretion Coupling in Insulin-releasing Cells*♦

P. Marchetti, J. Martinou, A. Wiederkehr, 2008, Journal of Biological Chemistry.

Regulation of inositol 1,4,5-trisphosphate-induced Ca2+ release from the endoplasmic reticulum by AMP-activated kinase modulators.

Pilar Alvarez-Illera, A. Wiederkehr, M. Montero, 2019, Cell calcium.

Mitochondrial signals drive insulin secretion in the pancreatic β-cell

A. Wiederkehr, C. Wollheim, 2012, Molecular and Cellular Endocrinology.

Requirement for Aralar and Its Ca2+-binding Sites in Ca2+ Signal Transduction in Mitochondria from INS-1 Clonal β-Cells*

A. Wiederkehr, C. Wollheim, J. Satrústegui, 2009, Journal of Biological Chemistry.

Macroencapsulated Human iPSC-Derived Pancreatic Progenitors Protect against STZ-Induced Hyperglycemia in Mice

P. Steiner, A. Wiederkehr, N. Bouché, 2019, Stem cell reports.

Pyruvate dehydrogenase E 1 α phosphorylation is induced by glucose but does not control metabolism-secretion coupling in INS-1 E clonal β-cells

A. Wiederkehr, C. Wollheim, U. Marchi, 2017 .

The motility-associated proteins GAP-43, MARCKS, and CAP-23 share unique targeting and surface activity-inducing properties.

P. Caroni, A. Wiederkehr, J. Staple, 1997, Experimental cell research.

Palmitate induces ER calcium depletion and apoptosis in mouse podocytes subsequent to mitochondrial oxidative stress

S. Choi, Shanhua Xu, Seong-Kyung Choi, 2015, Cell Death and Disease.

Differential Metabolism of Medium-Chain Fatty Acids in Differentiated Human-Induced Pluripotent Stem Cell-Derived Astrocytes

A. Wiederkehr, M. Masoodi, A. Chakrabarti, 2019, Front. Physiol..

Dynamic measurements of mitochondrial hydrogen peroxide concentration and glutathione redox state in rat pancreatic β-cells using ratiometric fluorescent proteins: confounding effects of pH with HyPer but not roGFP1.

A. Wiederkehr, P. Gilon, J. Duprez, 2012, The Biochemical journal.

Augmented mitochondrial energy metabolism is an early response to chronic glucose stress in human pancreatic beta cells

A. Valsesia, A. Wiederkehr, C. Wollheim, 2020, Diabetologia.

Pyruvate dehydrogenase E1α phosphorylation is induced by glucose but does not control metabolism-secretion coupling in INS-1E clonal β-cells.

A. Wiederkehr, C. Wollheim, U. De Marchi, 2012, Biochimica et biophysica acta.

A novel ATP-synthase-independent mechanism coupling mitochondrial activation to exocytosis in insulin-secreting cells

D. Barron, Aurélie Hermant, A. Wiederkehr, 2017, Journal of Cell Science.

Exploring Valine Metabolism in Astrocytic and Liver Cells: Lesson from Clinical Observation in TBI Patients for Nutritional Intervention

A. Wiederkehr, M. Masoodi, A. Chakrabarti, 2020, Biomedicines.

Reduction of plasma membrane glutamate transport potentiates insulin but not glucagon secretion in pancreatic islet cells

A. Wiederkehr, C. Wollheim, A. Gjinovci, 2011, Molecular and Cellular Endocrinology.

Mitochondrial lysine deacetylation promotes energy metabolism and calcium signaling in insulin‐secreting cells

Antonio Núñez Galindo, M. Kussmann, Aurélie Hermant, 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Cellular stress is a prerequisite for glucose-induced mitochondrial matrix alkalinization in pancreatic β-cells

A. Wiederkehr, J. Santo-Domingo, Jonathan Thévenet, 2019, Molecular and Cellular Endocrinology.

Gut-derived short-chain fatty acids modulate skin barrier integrity by promoting keratinocyte metabolism and differentiation

A. Wiederkehr, A. Nicolaou, C. von Garnier, 2022, Mucosal Immunology.

Functional specialization within a vesicle tethering complex

P. Novick, A. Wiederkehr, S. Ferro-Novick, 2004, The Journal of cell biology.

Essential Role of Mitochondrial Ca2+ Uniporter in the Generation of Mitochondrial pH Gradient and Metabolism-Secretion Coupling in Insulin-releasing Cells*

Jin Han, Shanhua Xu, Seong-Kyung Choi, 2014, The Journal of Biological Chemistry.

Linking Fatty Acid Stress to β-Cell Mitochondrial Dynamics

A. Wiederkehr, C. Wollheim, 2009, Diabetes.

Defective Mitochondrial Function and Motility Due to Mitofusin 1 Overexpression in Insulin Secreting Cells

A. Wiederkehr, C. Wollheim, Kyu-Sang Park, 2012, The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology.

Mitochondrial phosphate transport during nutrient stimulation of INS-1E insulinoma cells

G. Cline, Shanhua Xu, A. Wiederkehr, 2013, Molecular and Cellular Endocrinology.

Targeting mitochondrial ion channels in Type 2 diabetes.

A. Wiederkehr, J. Santo-Domingo, 2020, Future medicinal chemistry.

Matrix alkalinisation unleashes β-cell mitochondria

A. Wiederkehr, 2009, Islets.

The plant product quinic acid activates Ca2+‐dependent mitochondrial function and promotes insulin secretion from pancreatic beta cells

D. Barron, Aurélie Hermant, A. Wiederkehr, 2019, British journal of pharmacology.

Mitochondrial ion channels in pancreatic β‐cells: Novel pharmacological targets for the treatment of Type 2 diabetes

A. Wiederkehr, J. Santo-Domingo, U. De Marchi, 2020, British journal of pharmacology.

Minireview: implication of mitochondria in insulin secretion and action.

A. Wiederkehr, C. Wollheim, 2006, Endocrinology.

NCLX Protein, but Not LETM1, Mediates Mitochondrial Ca2+ Extrusion, Thereby Limiting Ca2+-induced NAD(P)H Production and Modulating Matrix Redox State*

A. Wiederkehr, N. Demaurex, I. Sekler, 2014, The Journal of Biological Chemistry.

Mitochondrial oxidative stress mediates high-phosphate-induced secretory defects and apoptosis in insulin-secreting cells.

Shanhua Xu, Seong-Kyung Choi, S. Cha, 2015, American journal of physiology. Endocrinology and metabolism.

Mitochondrial Dynamics and Oxidative Stress in Disease Mitochondrial oxidative stress mediates high-phosphate-induced secretory defects and apoptosis in insulin-secreting cells

Shanhua Xu, Seong-Kyung Choi, S. Cha, 2015 .

PDX1 deficiency causes mitochondrial dysfunction and defective insulin secretion through TFAM suppression.

F. Pattou, A. Wiederkehr, C. Wollheim, 2009, Cell metabolism.

A novel EH domain protein of Saccharomyces cerevisiae, Ede1p, involved in endocytosis.

H. Riezman, A. Wiederkehr, B. Winsor, 2000, Journal of cell science.

Impact of mitochondrial calcium on the coupling of metabolism to insulin secretion in the pancreatic beta-cell.

A. Wiederkehr, C. Wollheim, 2008, Cell calcium.

Corrigendum: Advances in pancreatic islet monolayer culture on glass surfaces enable super-resolution microscopy and insights into beta cell ciliogenesis and proliferation

S. Baekkeskov, J. Hubbell, A. Wiederkehr, 2017, Scientific Reports.

Advances in pancreatic islet monolayer culture on glass surfaces enable super-resolution microscopy and insights into beta cell ciliogenesis and proliferation

S. Baekkeskov, J. Hubbell, A. Wiederkehr, 2017, Scientific Reports.

Protein lysine acetylation: grease or sand in the gears of β-cell mitochondria?

A. Wiederkehr, L. Dayon, J. Santo-Domingo, 2020, Journal of molecular biology.

Calcium Co-regulates Oxidative Metabolism and ATP Synthase-dependent Respiration in Pancreatic Beta Cells

Umberto De Marchi, Aurelie Hermant, Aurélie Hermant, 2014, The Journal of Biological Chemistry.

Mitochondrial respiratory chain dysfunction alters ER sterol sensing and mevalonate pathway activity

Gregory Lefebvre, A. Wiederkehr, S. Métairon, 2022, The Journal of biological chemistry.

The F-Box Protein Rcy1p Is Involved in Endocytic Membrane Traffic and Recycling Out of an Early Endosome in Saccharomyces cerevisiae

Howard Riezman, H. Riezman, A. Wiederkehr, 2000, The Journal of cell biology.

Mitochondrial matrix calcium is an activating signal for hormone secretion.

Tullio Pozzan, Claus W Heizmann, Kristina Schoonjans, 2011, Cell metabolism.

Glucose-dependent phosphorylation signaling pathways and crosstalk to mitochondrial respiration in insulin secreting cells

Antonio Núñez Galindo, A. Wiederkehr, L. Dayon, 2019, Cell Communication and Signaling.

Modulation of the matrix redox signaling by mitochondrial Ca(2.).

A. Wiederkehr, J. Santo-Domingo, U. De Marchi, 2015, World journal of biological chemistry.

Skp1p and the F-Box Protein Rcy1p Form a Non-SCF Complex Involved in Recycling of the SNARE Snc1p in Yeast

M. Peter, R. Deshaies, H. Riezman, 2001, Molecular and Cellular Biology.

Antibiotics induce mitonuclear protein imbalance but fail to inhibit respiration and nutrient activation in pancreatic &bgr;‐cells

A. Wiederkehr, Steve Lassueur, J. Santo-Domingo, 2017, Experimental cell research.

The Human Diabetes Proteome Project (HDPP): The 2014 update

Ioannis Xenarios, Loïc Dayon, Young Ah Goo, 2015 .

Hepatic Nuclear Factor 1α (HNF1α) Dysfunction Down-regulates X-box-binding Protein 1 (XBP1) and Sensitizes β-Cells to Endoplasmic Reticulum Stress*

A. Wiederkehr, C. Wollheim, Haiyan Wang, 2011, The Journal of Biological Chemistry.

Normal Glucagon Signaling and β-Cell Function After Near-Total α-Cell Ablation in Adult Mice

P. Meda, A. Wiederkehr, C. Wollheim, 2011, Diabetes.

MitoRS, a method for high throughput, sensitive, and accurate detection of mitochondrial DNA heteroplasmy

Yiannis Kourmpetis, Gregory Lefebvre, F. Ronga, 2017, BMC Genomics.

Sec3p is needed for the spatial regulation of secretion and for the inheritance of the cortical endoplasmic reticulum.

P. Novick, A. Wiederkehr, M. Pypaert, 2003, Molecular biology of the cell.

Identification and characterization of Saccharomyces cerevisiae mutants defective in fluid‐phase endocytosis

H. Riezman, A. Wiederkehr, Karsten D. Meier, 2001, Yeast.

Coordinated activation of mitochondrial respiration and exocytosis mediated by PKC signaling in pancreatic β cells

Antonio Núñez Galindo, M. Kussmann, A. Wiederkehr, 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

CDN1163, an activator of sarco/endoplasmic reticulum Ca2+ ATPase, up‐regulates mitochondrial functions and protects against lipotoxicity in pancreatic β‐cells

A. Wiederkehr, C. Wollheim, Kyu-Sang Park, 2023, British journal of pharmacology.

Glucose-dependent phosphorylation signaling pathways and crosstalk to mitochondrial respiration in insulin secreting cells

Antonio Núñez Galindo, A. Wiederkehr, L. Dayon, 2019, Cell Communication and Signaling.

Regulation of autophagy by perilysosomal calcium: a new player in β-cell lipotoxicity

A. Wiederkehr, Ha Thu Nguyen, Claes B. Wollheim, 2024, Experimental & molecular medicine.