C. Wollheim

A. Wiederkehr, C. Wollheim, Kyu-Sang Park, 2012, The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology.

Possible role for calmodulin in insulin release. Studies with trifluoperazine in rat pancreatic islets.

C. Wollheim, Y. Krausz, G. Sharp, 1980, The Journal of clinical investigation.

Autocrine regulation of endothelial exocytosis: von Willebrand factor release is induced by prostacyclin in cultured endothelial cells

C. Wollheim, U. Vischer, U. Vischer, 1998, FEBS letters.

Ca2+ stores in insulin-secreting cells: lack of effect of cADP ribose.

G. Rutter, C. Wollheim, G. Rutter, 1994, Cell calcium.

Islet isolation from slaughterhouse pig pancreata: evidence of in vitro and in vivo function.

C. Wollheim, P. Morel, L. Bühler, 1994, Transplantation proceedings.

Foxa2 (HNF3β) Controls Multiple Genes Implicated in Metabolism-Secretion Coupling of Glucose-induced Insulin Release*

Haiyan Wang, C. Wollheim, Haiyan Wang, 2002, The Journal of Biological Chemistry.

Cytosolic free Ca2+ in insulin secreting cells and its regulation by isolated organelles

M. Prentki, C. Wollheim, 1984, Experientia.

Rapid Changes in Calcium Content of Rat Pancreatic Islets in Response to Glucose

C. Wollheim, A. Renold, G. Sharp, 1981, Diabetes.

Insulin release during fasting: studies on adenylate cyclase, phosphodiesterase, protein kinase, and phosphoprotein phosphatase in isolated islets of langerhans of the rat.

C. Wollheim, L. Lipson, G. Sharp, 1979, Endocrinology.

Evidence for the involvement of Na/Ca exchange in glucose-induced insulin release from rat pancreatic islets.

C. Wollheim, A. Renold, G. Sharp, 1980, The Journal of clinical investigation.

Postreceptor signalling of growth hormone and prolactin and their effects in the differentiated insulin-secreting cell line, INS-1.

C. Wollheim, N. Sekine, S. Ullrich, 1996, Endocrinology.

Different requirements for protein kinase C activation and Ca2+-independent insulin secretion in response to guanine nucleotides. Endogenously generated diacylglycerol requires elevated Ca2+ for kinase C insertion into membranes.

C. Wollheim, S. Ullrich, G. Li, 1989, The Journal of biological chemistry.

Activators of protein kinase C depolarize insulin‐secreting cells by closing K+ channels.

T. Pozzan, R. Bruzzone, O. Petersen, 1988, The EMBO journal.

Ca2+-mediated generation of inositol 1,4,5-triphosphate and inositol 1,3,4,5-tetrakisphosphate in pancreatic islets. Studies with K+, glucose, and carbamylcholine.

C. Wollheim, W. Schlegel, T. Biden, 1987, The Journal of biological chemistry.

Abnormal glucose metabolism accompanies failure of glucose to stimulate insulin release from a rat pancreatic cell line (RINm5F).

P. Halban, C. Wollheim, G. A. Praz, 1983, The Biochemical journal.

The MODY1 Gene for Hepatocyte Nuclear Factor 4 (cid:2) and a Feedback Loop Control COUP-TFII Expression in Pancreatic Beta Cells (cid:1)

M. Vasseur-Cognet, C. Wollheim, D. Scott, 2008 .

Mitochondrial phosphate transport during nutrient stimulation of INS-1E insulinoma cells

G. Cline, Shanhua Xu, A. Wiederkehr, 2013, Molecular and Cellular Endocrinology.

Glucose-Induced Insulin Secretion in INS-1 Cells Depends on Factors Present in Fetal Calf Serum and Rat Islet–Conditioned Medium

C. Wollheim, N. Sekine, C. Fasolato, 1997, Diabetes.

Ca2+ homeostasis in permeabilized human neutrophils. Characterization of Ca2+-sequestering pools and the action of inositol 1,4,5-triphosphate.

M. Prentki, C. Wollheim, P. Lew, 1984, The Journal of biological chemistry.

Cytosolic free calcium changes induced by chemotactic peptide in neutrophils from patients with chronic granulomatous disease

T. Pozzan, C. Wollheim, R. Seger, 1984 .

Cytosolic free calcium changes induced by chemotactic peptide in neutrophils from patients with chronic granulomatous disease.

T. Pozzan, C. Wollheim, R. Seger, 1984, Blood.

Effect of cholera toxin on insulin release in monolayer cultures of the endocrine pancreas

C. Wollheim, G. Sharp, B. Blondel, 1974, Diabetologia.

Cell motility and insulin release in monolayer cultures of endocrine pancreas

L. Orci, C. Wollheim, W. Malaisse, 1974 .

Galanin inhibits insulin secretion by direct interference with exocytosis

C. Wollheim, S. Ullrich, 1989, FEBS letters.

Characterization of alpha 2-adrenoceptors in a plasma membrane enriched fraction from the insulin-secreting cell line RINm5F.

C. Wollheim, S. Ullrich, 1989, Acta endocrinologica.

Dependency of acetylcholine-induced insulin release on Ca++ uptake by rat pancreatic islets.

C. Wollheim, G. Sharp, E. Siegel, 1980, Endocrinology.

Role of Ca2+ in impaired insulin release from islets of diabetic (C57BL/KsJ-db/db) mice.

C. Wollheim, A. Renold, G. Sharp, 1980, The American journal of physiology.

The possible importance of contact between pancreatic islet cells for the control of insulin release.

P. Meda, P. Halban, C. Wollheim, 1982, Endocrinology.

Reply to comment on: Biason-Lauber A, Boehm B, Lang-Muritano M et al. (2005) Association of childhood type 1 diabetes mellitus with a variant of PAX4: possible link to beta cell regenerative capacity. Diabetologia 48:900–905

C. Wollheim, M. Lang-Muritano, E. Schoenle, 2005, Diabetologia.

MAFA controls genes implicated in insulin biosynthesis and secretion

K. Kataoka, C. Wollheim, A. Sharma, 2007, Diabetologia.

A game plan for exocytosis.

C. Wollheim, J. Lang, 1994, Trends in cell biology.

Coordinated regulation of free Ca2+ by isolated organelles from a rat insulinoma.

M. Prentki, C. Wollheim, D. Janjic, 1984, Journal of Biological Chemistry.

Perturbation of hormone storage and release induced by cyproheptadine in rat pancreatic islets in vitro.

P. Halban, C. Wollheim, A. Renold, 1979, Endocrinology.

In vivo phosphorylation of the Na,K-ATPase alpha subunit in sciatic nerves of control and diabetic rats: effects of protein kinase modulators.

K. Geering, C. Wollheim, W. Pralong, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Pyridine nucleotide redox state parallels production of aldosterone in potassium-stimulated adrenal glomerulosa cells.

L. Hunyady, P. Várnai, C. Wollheim, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Possible role for mitochondrial calcium in angiotensin II- and potassium-stimulated steroidogenesis in bovine adrenal glomerulosa cells.

C. Wollheim, M. Rossier, M. Vallotton, 1996, Endocrinology.

Redistribution of ADP-ribosylation factor during stimulation of permeabilized cells with GTP analogues.

R. Kahn, C. Wollheim, S. Ullrich, 1991, The Biochemical journal.

Sodium requirement for insulin release: putative role in regulation of intracellular pH.

C. Wollheim, T. Biden, D. Janjic, 1986, The American journal of physiology.

Calmodulin in various insulin secreting cell types

C. Wollheim, A. Renold, D. Janjic, 1985, Journal of endocrinological investigation.

Cobalt inhibition of insulin release: evidence for an action not related to Ca2+ uptake.

C. Wollheim, D. Janjic, 1984, The American journal of physiology.

Involvement of Ca2+ in the Impaired Glucose-induced Insulin Release from Islets Cultured at Low Glucose

C. Wollheim, G. Sharp, D. Janjic, 1983, Diabetes.

Interactions of Ca2+, Mg2+, and Na+ in regulation of insulin release from rat islets.

C. Wollheim, D. Janjic, 1983, The American journal of physiology.

Selective inhibition of glucose-stimulated insulin release by dantrolene.

C. Wollheim, G. Sharp, D. Janjic, 1982, The American journal of physiology.

Sites of Action of Trifluoperazine in the Inhibition of Glucose-Stimulated Insulin Release

C. Wollheim, Y. Krausz, G. Sharp, 1981, Diabetes.

Beta-cell-targeted expression of a dominant-negative hepatocyte nuclear factor-1 alpha induces a maturity-onset diabetes of the young (MODY)3-like phenotype in transgenic mice.

C. Wollheim, H. Ishihara, P. Herrera, 2001, Endocrinology.

Extracellular ATP causes Ca2(+)-dependent and -independent insulin secretion in RINm5F cells. Phospholipase C mediates Ca2+ mobilization but not Ca2+ influx and membrane depolarization.

O. Petersen, C. Wollheim, G. Li, 1991, Journal of Biological Chemistry.

Regulation of insulin release by calcium.

C. Wollheim, G. Sharp, 1981, Physiological reviews.

Restoration of glucose‐induced insulin release in the absence of extracellular calcium by inhibition of the Na+‐pump

C. Wollheim, G. Sharp, E. Siegel, 1980, FEBS letters.

INS-1 Cells Undergoing Caspase-Dependent Apoptosis Enhance the Regenerative Capacity of Neighboring Cells

M. Byrne, J. Prehn, C. Wollheim, 2010, Diabetes.

Modulation of cytosolic-free calcium transients by changes in intracellular calcium-buffering capacity: correlation with exocytosis and O2-production in human neutrophils

T. Pozzan, C. Wollheim, F. Waldvogel, 1984, The Journal of cell biology.

Is cytosolic ionized calcium regulating neutrophil activation?

C B Wollheim, R Y Tsien, R. Tsien, 1983, Science.

Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes

S. Friend, B. Mecham, J. Derry, 2017, Science Translational Medicine.

Islet cell metabolism is reflected by the MTT (tetrazolium) colorimetric assay

C. Wollheim, D. Janjic, D. Janjic, 1992, Diabetologia.

Rapid mobilization of Ca2+ from rat insulinoma microsomes by inositol-1,4,5-trisphosphate

M. Berridge, M. Prentki, C. Wollheim, 1984, Nature.

Minireview: implication of mitochondria in insulin secretion and action.

A. Wiederkehr, C. Wollheim, 2006, Endocrinology.

Mitochondrial function in normal and diabetic beta-cells.

C. Wollheim, P. Maechler, 2001, Nature.

Single cell monitoring of cytosolic calcium reveals subtypes of rat lactotrophs with distinct responses to dopamine and thyrotropin-releasing hormone.

C. Wollheim, W. Schlegel, G. Zahnd, 1987, Endocrinology.

Characterization of Pancreatic Transcription Factor Pdx-1 Binding Sites Using Promoter Microarray and Serial Analysis of Chromatin Occupancy*

K. Kaestner, S. McWeeney, P. White, 2007, Journal of Biological Chemistry.

Genome-Wide DNA Methylation Analysis of Human Pancreatic Islets from Type 2 Diabetic and Non-Diabetic Donors Identifies Candidate Genes That Influence Insulin Secretion

Elin Hall, Lena Eliasson, Petr Volkov, 2014, PLoS genetics.

Type 2 Diabetes Susceptibility Gene Expression in Normal or Diabetic Sorted Human Alpha and Beta Cells: Correlations with Age or BMI of Islet Donors

M. Bugliani, P. Marchetti, F. Pattou, 2010, PloS one.

Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes

E. Bonifacio, U. Boggi, E. Petretto, 2017, Diabetologia.

Intracellular degradation of insulin stores by rat pancreatic islets in vitro. An alternative pathway for homeostasis of pancreatic insulin content.

P. Halban, C. Wollheim, 1980, The Journal of biological chemistry.

Increased DNA Methylation and Decreased Expression of PDX-1 in Pancreatic Islets from Patients with Type 2 Diabetes.

C. Ling, M. Nitert, C. Wollheim, 2012 .

Activation of the unfolded protein response pathway causes ceramide accumulation in yeast and INS-1E insulinoma cells

H. Riezman, C. Wollheim, Isabelle Riezman, 2012, Journal of Lipid Research.

Pathophysiology of type 2 diabetes and the impact of altered metabolic interorgan crosstalk

P. Kaldis, C. Wollheim, A. Salehi, 2021, The FEBS journal.

Elevated miR-130a/miR130b/miR-152 expression reduces intracellular ATP levels in the pancreatic beta cell

L. Eliasson, H. Mulder, C. Wollheim, 2017, Scientific Reports.

The HNF-1 target collectrin controls insulin exocytosis by SNARE complex formation.

H. Kasai, Y. Matsuzawa, I. Shimomura, 2005, Cell metabolism.

β-Cell Biology of Insulin Secretion

C. Wollheim, P. Maechler, 2003 .

Hepatocyte Nuclear Factor 4α Regulates the Expression of Pancreatic β-Cell Genes Implicated in Glucose Metabolism and Nutrient-induced Insulin Secretion*

C. Wollheim, Haiyan Wang, P. Antinozzi, 2000, The Journal of Biological Chemistry.

Gene expression profiles during beta cell maturation and after IL-1β exposure reveal important roles of Pdx-1 and Nkx6.1 for IL-1β sensitivity

T. Ørntoft, M. Kruhøffer, J. Nerup, 2004, Diabetologia.

Gene expression profiles during beta cell maturation and after IL-1beta exposure reveal important roles of Pdx-1 and Nkx6.1 for IL-1beta sensitivity.

M. Kruhøffer, J. Nerup, C. Wollheim, 2004, Diabetologia.

Modulation of Neuronal Pentraxin 1 Expression in Rat Pancreatic β-Cells Submitted to Chronic Glucotoxic Stress

C. Wollheim, Jean-Charles Sanchez, Y. Brunner, 2012, Molecular & Cellular Proteomics.

Effect of 2-mercaptoethanol on glutathione levels, cystine uptake and insulin secretion in insulin-secreting cells.

C. Wollheim, D. Janjic, 1992, European journal of biochemistry.

Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines.

C B Wollheim, P. Meda, P. Halban, 1992, Endocrinology.

ChREBP Rather than USF2 Regulates Glucose Stimulation of Endogenous L-pyruvate Kinase Expression in Insulin-secreting Cells*

C. Wollheim, Haiyan Wang, 2002, The Journal of Biological Chemistry.

TCF7L2 is a master regulator of insulin production and processing

L. Groop, M. Nóbrega, J. Rung, 2014, bioRxiv.

Caerulein and carbamoylcholine stimulate pancreatic amylase release at resting cytosolic free Ca2+.

T. Pozzan, R. Bruzzone, C. Wollheim, 1986, The Biochemical journal.

Phenytoin Inhibition of Insulin Release: Studies on the Involvement of Ca2+ Fluxes in Rat Pancreatic Islets

C. Wollheim, D. Janjic, E. Siegel, 1982, Diabetes.

The Transcription Factor SREBP-1c Is Instrumental in the Development of β-Cell Dysfunction*

C. Wollheim, Haiyan Wang, P. Antinozzi, 2003, The Journal of Biological Chemistry.

Early activation of the fatty acid metabolism pathway by chronic high glucose exposure in rat insulin secretory β‐cells

Céline Hernandez, F. Lisacek, A. Masselot, 2010, Proteomics.

Gluco-incretins control insulin secretion at multiple levels as revealed in mice lacking GLP-1 and GIP receptors.

Tanya Hansotia, D. Drucker, C. Wollheim, 2004, The Journal of clinical investigation.

Oscillations of cytosolic Ca2+ in pituitary cells due to action potentials

C. Wollheim, W. Schlegel, B. Dufy, 1987, Nature.

Beta-cell mitochondria and insulin secretion: messenger role of nucleotides and metabolites.

C. Wollheim, Claes B Wollheim, Pierre Maechler, 2002, Diabetes.

Excess maternal transmission of variants in the THADA gene to offspring with type 2 diabetes

L. Groop, S. Pääbo, M. Lachmann, 2016, Diabetologia.

Mitochondrial oxidative stress mediates high-phosphate-induced secretory defects and apoptosis in insulin-secreting cells.

Shanhua Xu, Seong-Kyung Choi, S. Cha, 2015, American journal of physiology. Endocrinology and metabolism.

Mitochondrial Dynamics and Oxidative Stress in Disease Mitochondrial oxidative stress mediates high-phosphate-induced secretory defects and apoptosis in insulin-secreting cells

Shanhua Xu, Seong-Kyung Choi, S. Cha, 2015 .

PDX1 deficiency causes mitochondrial dysfunction and defective insulin secretion through TFAM suppression.

F. Pattou, A. Wiederkehr, C. Wollheim, 2009, Cell metabolism.

GAD65-mediated Glutamate Decarboxylation Reduces Glucose-stimulated Insulin Secretion in Pancreatic Beta Cells*

C. Wollheim, F. Hegardt, H. Ishihara, 2001, The Journal of Biological Chemistry.

DNA methylation of the glucagon-like peptide 1 receptor (GLP1R) in human pancreatic islets

C. Ling, C. Wollheim, M. Dekker Nitert, 2013, BMC Medical Genetics.

Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis

C. Wollheim, P. Maechler, 1999, Nature.

ER stress and SREBP-1 activation are implicated in β-cell glucolipotoxicity

C. Wollheim, Haiyan Wang, G. Kouri, 2005, Journal of Cell Science.

Molecular targets of a human HNF1α mutation responsible for pancreatic β‐cell dysfunction

C. Wollheim, Haiyan Wang, P. Antinozzi, 2000 .

Time-resolved metabolomics analysis of β-cells implicates the pentose phosphate pathway in the control of insulin release.

P. Spégel, H. Mulder, C. Wollheim, 2013, The Biochemical journal.

Mitochondrial GTP regulates glucose-stimulated insulin secretion.

G. Shulman, G. Cline, R. Kibbey, 2007, Cell metabolism.

Impact of mitochondrial calcium on the coupling of metabolism to insulin secretion in the pancreatic beta-cell.

A. Wiederkehr, C. Wollheim, 2008, Cell calcium.

Loss of connexin36 channels alters beta-cell coupling, islet synchronization of glucose-induced Ca2+ and insulin oscillations, and basal insulin release.

Paolo Meda, M. Ravier, K. Willecke, 2005, Diabetes.

Mitochondrial signals in glucose‐stimulated insulin secretion in the beta cell

C. Wollheim, P. Maechler, Pierre Maechler, 2000, The Journal of physiology.

C. Wollheim, Haiyan Wang, J. Lou, 2009, The international journal of biochemistry & cell biology.

Guanine nucleotides induce Ca2+-independent insulin secretion from permeabilized RINm5F cells.

C. Wollheim, T. Biden, L. Vallar, 1987, The Journal of biological chemistry.

Single islet beta‐cell stimulation by nutrients: relationship between pyridine nucleotides, cytosolic Ca2+ and secretion.

C. Wollheim, W. Pralong, C. Bartley, 1990, The EMBO journal.

Continuous monitoring of ATP levels in living insulin secreting cells expressing cytosolic firefly luciferase

C. Wollheim, Haiyan Wang, P. Maechler, 1998, FEBS letters.

Inositol 1,4,5-trisphosphate and intracellular Ca2+ homeostasis in clonal pituitary cells (GH3). Translocation of Ca2+ into mitochondria from a functionally discrete portion of the nonmitochondrial store.

C. Wollheim, W. Schlegel, T. Biden, 1986, The Journal of biological chemistry.

TCF 7 L 2 is a master regulator of insulin production and processing

L. Groop, M. Nóbrega, J. Rung, 2014 .

Functional and morphological abnormalities of mitochondria harbouring the tRNALeu(UUR) mutation in mitochondrial DNA derived from patients with maternally inherited diabetes and deafness (MIDD) and progressive kidney disease

J. Maassen, C. Wollheim, J. V. D. van den Ouweland, 1999, Diabetologia.

Identification of novel genes for glucose metabolism based upon expression pattern in human islets and effect on insulin secretion and glycemia.

Emma Ahlqvist, Leif Groop, L. Groop, 2015, Human molecular genetics.

α, βI, βII, δ, and ε Protein Kinase C Isoforms and Compound Activity in the Sciatic Nerve of Normal and Diabetic Rats

G. Ferrari, C. Wollheim, R. Regazzi, 1994 .

Mitochondrial Calcium Oscillations in C2C12 Myotubes*

C. Wollheim, U. Ruegg, P. Maechler, 2001, The Journal of Biological Chemistry.

Bone Morphogenetic Protein 3 Controls Insulin Gene Expression and Is Down-regulated in INS-1 Cells Inducibly Expressing a Hepatocyte Nuclear Factor 1A-Maturity-onset

M. Byrne, H. Düssmann, J. Prehn, 2011 .

Dominant‐negative suppression of HNF‐1α function results in defective insulin gene transcription and impaired metabolism‐secretion coupling in a pancreatic β‐cell line

C. Wollheim, Haiyan Wang, P. Maechler, 1998, The EMBO journal.

Improved characterization of the insulin secretory granule proteomes.

M. Foti, C. Wollheim, Jean-Charles Sanchez, 2012, Journal of proteomics.

Ablation of GPR56 Causes β-Cell Dysfunction by ATP Loss through Mistargeting of Mitochondrial VDAC1 to the Plasma Membrane

C. Wollheim, A. Salehi, P. Dunér, 2023, Biomolecules.

Somatostatin inhibition of Ca2(+)-induced insulin secretion in permeabilized HIT-T15 cells.

M. Prentki, C. Wollheim, S. Ullrich, 1990, The Biochemical journal.

Diacylglycerol as messenger

O. Petersen, C. Wollheim, 1990, Nature.

TRB3 is implicated in glucotoxicity- and ER-stress-induced beta-cell apoptosis

C. Wollheim, Haiyan Wang, J. Lou, 2008 .

TRIB3 is implicated in glucotoxicity- and oestrogen receptor-stress-induced b -cell apoptosis

C. Wollheim, Haiyan Wang, J. Lou, 2008 .

Spontaneous and chemoattractant-induced oscillations of cytosolic free calcium in single adherent human neutrophils.

C. Wollheim, W. Schlegel, M. Jaconi, 1988, The Journal of biological chemistry.

Calcium-calmodulin stimulates inositol 1,4,5-trisphosphate kinase activity from insulin-secreting RINm5F cells.

J. Cox, C. Wollheim, T. Biden, 1987, The Journal of biological chemistry.

Mitochondrial matrix calcium is an activating signal for hormone secretion.

Tullio Pozzan, Claus W Heizmann, Kristina Schoonjans, 2011, Cell metabolism.

35th Annual meeting of the European Association for the Study of Diabetes. Brussels, Belgium, 28 September-2 October, 1999. Abstracts.

Thomas J. Smith, B. M. Rasmussen, V. C. Phan, 1999, Diabetologia.

Dopamine regulates pancreatic glucagon and insulin secretion via adrenergic and dopaminergic receptors

D. Sibley, Z. Freyberg, C. Wollheim, 2021, Translational Psychiatry.

CART is overexpressed in human type 2 diabetic islets and inhibits glucagon secretion and increases insulin secretion

L. Groop, V. Lyssenko, M. Kuhar, 2016, Diabetologia.

Glucose sensitivity and metabolism-secretion coupling studied during two-year continuous culture in INS-1E insulinoma cells.

S. Theander, C. Wollheim, P. Maechler, 2004, Endocrinology.

The MODY1 Gene for Hepatocyte Nuclear Factor 4α and a Feedback Loop Control COUP-TFII Expression in Pancreatic Beta Cells

M. Vasseur-Cognet, C. Wollheim, D. Scott, 2008, Molecular and Cellular Biology.

Epigallocatechin-3-gallate (EGCG) activates AMPK through the inhibition of glutamate dehydrogenase in muscle and pancreatic ß-cells: A potential beneficial effect in the pre-diabetic state?

C. Wollheim, H. Waagepetersen, M. Stridh, 2017, The international journal of biochemistry & cell biology.

The diabetes-linked transcription factor PAX4 promotes β-cell proliferation and survival in rat and human islets

C. Wollheim, E. Schoenle, B. Gauthier, 2004, The Journal of cell biology.

Ca2+‐independent insulin exocytosis induced by α‐latrotoxin requires latrophilin, a G protein‐coupled receptor

C. Wollheim, Y. Ushkaryov, J. Lang, 1998, The EMBO journal.

Suppression of Pdx-1 perturbs proinsulin processing, insulin secretion and GLP-1 signalling in INS-1 cells

S. Theander, P. Halban, C. Wollheim, 2005, Diabetologia.

Increase in cellular glutamate levels stimulates exocytosis in pancreatic β‐cells

J. Gromada, C. Wollheim, P. Berggren, 2002, FEBS letters.

The liver receptor homolog-1 (LRH-1) is expressed in human islets and protects {beta}-cells against stress-induced apoptosis.

P. Marchetti, F. Pattou, C. Wollheim, 2011, Human molecular genetics.

Ca 2-independent insulin exocytosis induced by α-latrotoxin requires latrophilin , a G protein-coupled receptor

C. Wollheim, Y. Ushkaryov, J. Lang, 2013 .

Secretagogues Modulate the Calcium Concentration in the Endoplasmic Reticulum of Insulin-secreting Cells

T. Pozzan, C. Wollheim, A. Valeva, 1999, The Journal of Biological Chemistry.

Rapid 'on-line' image processing as a tool in the evaluation of kinetic and morphological aspects of receptor-induced cell activation.

J M Theler, C B Wollheim, W Schlegel, 1991, Journal of receptor research.

Monitoring receptor mediated regulation of cytosolic calcium in single pituitary cells by dual excitation microfluorimetry.

C. Wollheim, W. Schlegel, G. Zahnd, 1988, Journal of receptor research.

Hepatic Nuclear Factor 1α (HNF1α) Dysfunction Down-regulates X-box-binding Protein 1 (XBP1) and Sensitizes β-Cells to Endoplasmic Reticulum Stress*

A. Wiederkehr, C. Wollheim, Haiyan Wang, 2011, The Journal of Biological Chemistry.

ER stress and SREBP-1 activation are implicated in beta-cell glucolipotoxicity.

C. Wollheim, Haiyan Wang, G. Kouri, 2005, Journal of cell science.

Secreted frizzled-related protein 4 reduces insulin secretion and is overexpressed in type 2 diabetes.

L. Groop, L. Eliasson, V. Lyssenko, 2012, Cell metabolism.

Intracellular alkalinization by phosphate uptake via type III sodium–phosphate cotransporter participates in high‐phosphate‐induced mitochondrial oxidative stress and defective insulin secretion

Shanhua Xu, S. Cha, C. Wollheim, 2016, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Association of childhood type 1 diabetes mellitus with a variant of PAX4: possible link to beta cell regenerative capacity

C. Wollheim, M. Lang-Muritano, E. Schoenle, 2005, Diabetologia.

Normal Glucagon Signaling and β-Cell Function After Near-Total α-Cell Ablation in Adult Mice

P. Meda, A. Wiederkehr, C. Wollheim, 2011, Diabetes.

HNF 3 β ) controls multiple genes implicated in metabolism-secretion coupling of glucose-induced insulin release

C. Wollheim, Haiyan Wang, M. Iezzi, 2002 .

Silencing of the FTO gene inhibits insulin secretion: An in vitro study using GRINCH cells

L. Groop, P. Arvan, R. Prasad, 2018, Molecular and Cellular Endocrinology.

Monolayer cell culture of neonatal rat pancreas: an ultrastructural and biochemical study of functioning endocrine cells.

C B Wollheim, Y Kanazawa, L Orci, 1973, Journal of ultrastructure research.

The stimulatory effect of rabphilin 3a on regulated exocytosis from insulin-secreting cells does not require an association-dissociation cycle with membranes mediated by Rab 3.

P. De Camilli, C. Wollheim, R. Regazzi, 1997, European journal of cell biology.

Human insulin gene is a target gene of hepatocyte nuclear factor-1alpha (HNF-1alpha) and HNF-1beta.

Y. Matsuzawa, C. Wollheim, K. Yamagata, 1999, Biochemical and biophysical research communications.

The structure of insulin granule core determines secretory capacity being reduced in type-2 diabetes

L. Eliasson, A. Blom, C. Wollheim, 2022, bioRxiv.

Beta-cell mitochondria in the regulation of insulin secretion: a new culprit in Type II diabetes

C. Wollheim, C. Wollheim, 2000, Diabetologia.

Importance of cellular calcium stores in glucose-stimulated insulin release.

C. Wollheim, M. Kikuchi, G. Sharp, 1981, Upsala journal of medical sciences.

In Vivo Conditional Pax4 Overexpression in Mature Islet β-Cells Prevents Stress-Induced Hyperglycemia in Mice

P. Meda, K. He, C. Wollheim, 2011, Diabetes.

ATP-sensitive K+ channels in an insulin-secreting cell line are inhibited byd-glyceraldehyde and activated by membrane permeabilization

O. Petersen, C. Wollheim, O. Petersen, 2005, The Journal of Membrane Biology.

Nonselective inhibition of neutrophil functions by sphinganine.

K. Krause, R. Bruzzone, C. Wollheim, 1987, Journal of Biological Chemistry.

CDN1163, an activator of sarco/endoplasmic reticulum Ca2+ ATPase, up‐regulates mitochondrial functions and protects against lipotoxicity in pancreatic β‐cells

A. Wiederkehr, C. Wollheim, Kyu-Sang Park, 2023, British journal of pharmacology.

Junctional communication of pancreatic beta cells contributes to the control of insulin secretion and glucose tolerance.

A. Charollais, P. Meda, C. Wollheim, 2000, The Journal of clinical investigation.

Facilitation of fatty acid uptake by CD36 in insulin-producing cells reduces fatty-acid-induced insulin secretion and glucose regulation of fatty acid oxidation.

C. Wollheim, Haiyan Wang, M. Iezzi, 2010, Biochimica et biophysica acta.

Human Krüppel-like factor 11 differentially regulates human insulin promoter activity in β-cells and non-β-cells via p300 and PDX1 through the regulatory sites A3 and CACCC box

C. Wollheim, Haiyan Wang, J. Seufert, 2012, Molecular and Cellular Endocrinology.

Human Krüppel-like factor 11 differentially regulates human insulin promoter activity in β-cells and non-β-cells via p 300 and PDX 1 through the regulatory sites A 3 and CACCC box PERAKAKIS

C. Wollheim, Haiyan Wang, J. Seufert, 2017 .

Regulation of inositol 1,4,5-trisphosphate metabolism in insulin-secreting RINm5F cells.

C. Wollheim, T. Biden, L. Vallar, 1988, The Biochemical journal.

Endogenous beta-cell CART regulates insulin secretion and transcription of beta-cell genes

L. Eliasson, N. Wierup, O. Hansson, 2017, Molecular and Cellular Endocrinology.

Palmitate induces ER calcium depletion and apoptosis in mouse podocytes subsequent to mitochondrial oxidative stress

S. Choi, Shanhua Xu, Seong-Kyung Choi, 2015, Cell Death and Disease.

The Human Pancreatic Islet Methylome and Its Role in Type 2 Diabetes

C. Ling, M. Nitert, C. Wollheim, 2012 .

ER stress and SREBP-1 activation are implicated in β-cell glucolipotoxicity

C. Wollheim, Haiyan Wang, G. Kouri, 2005, Journal of Cell Science.

ER stress and SREBP-1 activation are implicated in β-cell glucolipotoxicity

C. Wollheim, Haiyan Wang, G. Kouri, 2005, Journal of Cell Science.

Increased uptake of oxLDL does not exert lipotoxic effects in insulin-secreting cells.

C. Wollheim, V. Grill, Z. Ma, 2019, Journal of molecular endocrinology.

What Couples Glycolysis to Mitochondrial Signal Generation in Glucose‐Stimulated Insulin Secretion?

C. Wollheim, H. Ishihara, 2000, IUBMB Life - A Journal of the International Union of Biochemistry and Molecular Biology.

Energy dispersive X-ray microanalysis of zinc and calcium in organelles of insulin-producing cells of the mouse, rat, and a fish.

M. Prentki, C. Wollheim, S. Falkmer, 1985, Biomedica biochimica acta.

Islet Gene View—a tool to facilitate islet research

L. Groop, T. Tuomi, I. Artner, 2022, Life Science Alliance.

Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism

L. Groop, B. Di Camillo, L. Eliasson, 2014, Proceedings of the National Academy of Sciences.

Endogenous beta-cell CART regulates insulin secretion and transcription of beta-cell genes

L. Eliasson, N. Wierup, O. Hansson, 2017, Molecular and Cellular Endocrinology.

A natural interleukin 1 (IL-1) inhibitor counteracts the inhibitory effect of IL-1 on insulin production in cultured rat pancreatic islets.

C. Wollheim, J. Dayer, C. Wollheim, 1989, Journal of autoimmunity.

SNAP-25 is expressed in islets of Langerhans and is involved in insulin release

P. Halban, C. Wollheim, C. Montecucco, 1995, The Journal of cell biology.

Modulation of cytosolic-free calcium transients by changes in intracellular calcium-buffering capacity: correlation with exocytosis and O2-production in human neutrophils

T. Pozzan, C. Wollheim, F. Waldvogel, 1984, The Journal of cell biology.

Reduced insulin secretion and content in VEGF-a deficient mouse pancreatic islets.

J. Gromada, C. Wollheim, N. Ferrara, 2008, Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association.

In vitro function of human cryopreserved islets of Langerhans.

C. Wollheim, P. Morel, L. Bühler, 1996, Transplantation proceedings.

The diabetes-linked transcription factor PAX4 promotes β-cell proliferation and survival in rat and human islets

C. Wollheim, E. Schoenle, B. Gauthier, 2004, The Journal of cell biology.

Voices: Insulin and beyond.

F. Ashcroft, J. Holst, R. Bergman, 2021, Cell metabolism.

GABA in the Endocrine Pancreas

C. Wollheim, I. Franklin, 2004, The Journal of general physiology.

Hepatocyte nuclear factor 4alpha regulates the expression of pancreatic beta -cell genes implicated in glucose metabolism and nutrient-induced insulin secretion.

C. Wollheim, P. Antinozzi, P. Maechler, 2000, The Journal of biological chemistry.