C. Farquharson

发表

Skeletal energy homeostasis: a paradigm of endocrine discovery.

K. Suchacki, F. Roberts, Andrea Lovdel, 2017, The Journal of endocrinology.

Chondrogenic ATDC5 cells: An optimised model for rapid and physiological matrix mineralisation

A. Boskey, C. Farquharson, A. Canfield, 2012, International journal of molecular medicine.

Total Protein Analysis as a Reliable Loading Control for Quantitative Fluorescent Western Blotting

C. Farquharson, S. Eaton, T. Gillingwater, 2013, PloS one.

Glucocorticoid effects on chondrogenesis, differentiation and apoptosis in the murine ATDC5 chondrocyte cell line.

C. Farquharson, S. Ahmed, T. Mushtaq, 2002, The Journal of endocrinology.

Cartilage development and degeneration: a Wnt Wnt situation

C. Farquharson, V. Macrae, K. Staines, 2012, Cell biochemistry and function.

Elevated expression of hypoxia inducible factor‐2α in terminally differentiating growth plate chondrocytes

C. Farquharson, A. Stewart, B. Houston, 2006, Journal of cellular physiology.

PLA2 and ENPP6 may act in concert to generate phosphocholine from the matrix vesicle membrane during skeletal mineralization

C. Farquharson, A. Stewart, Darren T K Leong, 2018, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Explorer Cartilage to bone transitions in health and disease

A. Pollard, I. McGonnell, A. Pitsillides, 2017 .

Combined growth hormone and insulin-like growth factor-1 rescues growth retardation in glucocorticoid-treated mdxmice but does not prevent osteopenia

C. Farquharson, S. Ahmed, S. C. Wong, 2022, The Journal of endocrinology.

SOCS2 is the critical regulator of GH action in murine growth plate chondrogenesis

C. Farquharson, V. Macrae, C. Pass, 2012, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

The effect of GH and IGF1 on linear growth and skeletal development and their modulation by SOCS proteins.

C. Farquharson, S. Ahmed, S. F. Ahmed, 2010, The Journal of endocrinology.

Inflammatory cytokines and the GH/IGF‐I axis: novel actions on bone growth

C. Farquharson, S. Ahmed, V. MacRae, 2009, Cell biochemistry and function.

The importance of the SIBLING family of proteins on skeletal mineralisation and bone remodelling.

C. Farquharson, V. Macrae, K. Staines, 2012, The Journal of endocrinology.

Mechanisms and Clinical Consequences of Vascular Calcification

C. Farquharson, V. Macrae, Dongxing Zhu, 2012, Front. Endocrin..

Mechanisms and Clinical Consequences of Vascular Calcification

C. Farquharson, V. Macrae, Dongxing Zhu, 2012, Front. Endocrin..

Endocrinology of Bone and Growth Disorders

C. Farquharson, S. C. Wong, L. Stephen, 2021, Reference Module in Biomedical Sciences.

Human PHOSPHO1 exhibits high specific phosphoethanolamine and phosphocholine phosphatase activities.

P. Sadler, C. Farquharson, A. Stewart, 2004, The Biochemical journal.

Differences in metabolic parameters and gene expression related to osteochondrosis/osteoarthrosis in pigs fed 25-hydroxyvitamin D3.

William Smith, C. Farquharson, H. McCormack, 2002, Veterinary research.

Dietary effects on bone quality and turnover, and Ca and P metabolism in chickens.

D. Waddington, C. Farquharson, S. Solomon, 2000, Research in veterinary science.

Microtubules are potential regulators of growth-plate chondrocyte differentiation and hypertrophy.

C. Farquharson, B. Houston, D. Lester, 1999, Bone.

Evidence of ultracytochemical mitochondria-derived hydrogen peroxide activity in myocardial cells from broiler chickens with an ascites syndrome.

C. Farquharson, M. H. Maxwell, G. Robertson, 1996, Research in veterinary science.

Expression of Sulf1 and Sulf2 in cartilage, bone and endochondral fracture healing

C. Farquharson, C. Chenu, J. Dudhia, 2015, Histochemistry and Cell Biology.

E11/Podoplanin Protein Stabilization Through Inhibition of the Proteasome Promotes Osteocyte Differentiation in Murine in Vitro Models

A. Pitsillides, C. Farquharson, S. Allen, 2015, Journal of cellular physiology.

PHOSPHO1, a novel skeletal regulator of insulin resistance and obesity

K. Suchacki, C. Farquharson, W. Cawthorn, 2020, bioRxiv.

PHOSPHO1 is a skeletal regulator of insulin resistance and obesity

J. Millán, K. Suchacki, C. Farquharson, 2020, BMC biology.

Optimised isolation method for RNA extraction suitable for RNA sequencing from feline teeth collected in a clinical setting and at post mortem

C. Farquharson, U. Trivedi, Seungmee Lee, 2018, Veterinary research communications.

The restricted potential for recovery of growth plate chondrogenesis and longitudinal bone growth following exposure to pro-inflammatory cytokines.

C. Farquharson, V. Macrae, S. Ahmed, 2006, The Journal of endocrinology.

Deficiency of the bone mineralization inhibitor NPP1 protects mice against obesity and diabetes

J. Millán, C. Farquharson, V. Macrae, 2014, Disease Models & Mechanisms.

Comparative modelling of human PHOSPHO1 reveals a new group of phosphatases within the haloacid dehalogenase superfamily.

C. Farquharson, R. Schmid, A. Stewart, 2003, Protein engineering.

Differential Expression of Alkaline Phosphatase and PHOSPHO1 in Bone from a Murine Model of Chronic Kidney Disease

J. Millán, C. Farquharson, L. Millán, 2021 .

The Appearance and Modulation of Osteocyte Marker Expression during Calcification of Vascular Smooth Muscle Cells

J. Millán, C. Farquharson, V. Macrae, 2011, PloS one.

The differentiation and calcification of vascular smooth muscle cells is associated with an osteocyte phenotype

C. Farquharson, V. Macrae, Dongxing Zhu, 2010 .

A Guide to Modern Quantitative Fluorescent Western Blotting with Troubleshooting Strategies

C. Farquharson, S. Eaton, T. Gillingwater, 2014, Journal of visualized experiments : JoVE.

Increased PHOSPHO1 expression mediates cortical bone mineral density in renal osteodystrophy

A. Pitsillides, J. Millán, C. Farquharson, 2021, bioRxiv.

Animal models to explore the effects of glucocorticoids on skeletal growth and structure.

C. Farquharson, S. Ahmed, S. C. Wong, 2018, The Journal of endocrinology.

Proton Pump Inhibitors Inhibit PHOSPHO1 Activity and Matrix Mineralisation In Vitro

S. Ralston, C. Farquharson, K. Staines, 2021, Calcified Tissue International.

Kidney lesions in copper-deficient rats.

C. Farquharson, G. Riddoch, B. Fell, 1987, Journal of comparative pathology.

Growth plate chondrocyte vitamin D receptor number and affinity are reduced in avian tibial dyschondroplastic lesions.

C. Farquharson, J. Berry, E. Mawer, 1996, Bone.

Suppressor of cytokine signaling 2 (Socs2) deletion protects bone health of mice with DSS-induced inflammatory bowel disease

C. Farquharson, V. Macrae, S. Ahmed, 2018, Disease Models & Mechanisms.

Suppressor of cytokine signaling 2 (Socs2) deletion protects bone health of mice with DSS-induced inflammatory bowel disease

C. Farquharson, V. Macrae, S. Ahmed, 2018, Disease Models & Mechanisms.

The pathophysiology of the growth plate in juvenile idiopathic arthritis.

C. Farquharson, V. Macrae, S. Ahmed, 2006, Rheumatology.

Ceramide inhibition of chondrocyte proliferation and bone growth is IGF-I independent.

C. Farquharson, V. Macrae, S. Ahmed, 2006, The Journal of endocrinology.

Visualisation and selective elimination of a subpopulation of mitogen-responsive bone marrow stromal cells using bromodeoxyuridine and photo-induced cell killing.

C. Farquharson, B. Thomson, B. Noble, 1993, Bone.

Cell proliferation within the growth plate of long bones assessed by bromodeoxyuridine uptake and its relationship to glucose 6-phosphate dehydrogenase activity.

C. Farquharson, N. Loveridge, Nigel Loveridge, 1990, Bone and mineral.

Ascorbic acid-induced chondrocyte terminal differentiation: the role of the extracellular matrix and 1,25-dihydroxyvitamin D.

C. Farquharson, J. Berry, E. Mawer, 1998, European journal of cell biology.

Regulators of chondrocyte differentiation in tibial dyschondroplasia: an in vivo and in vitro study.

C. Farquharson, J. Berry, E. Mawer, 1995, Bone.

Endogenous mediators of growth

C. Farquharson, N. Loveridge, B. Scheven, 1990, Proceedings of the Nutrition Society.

Intravesicular Phosphatase PHOSPHO1 Function in Enamel Mineralization and Prism Formation

T. Diekwisch, J. Millán, C. Farquharson, 2017, Front. Physiol..

The proto‐oncogene C‐myc is involved in cell differentiation as well as cell proliferation: Studies on growth plate chondrocytes in situ

J. Hesketh, C. Farquharson, N. Loveridge, 1992, Journal of cellular physiology.

IGF-I signalling in bone growth: inhibitory actions of dexamethasone and IL-1beta.

C. Farquharson, V. Macrae, S. Ahmed, 2007, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.

Ubiquitin-protein ligase Ubr5 cooperates with hedgehog signalling to promote skeletal tissue homeostasis

S. Ralston, C. Farquharson, D. Salter, 2020, bioRxiv.

Dexamethasone-induced expression of the glucocorticoid response gene lipocalin 2 in chondrocytes.

C. Farquharson, S. Ahmed, H. Owen, 2008, American journal of physiology. Endocrinology and metabolism.

Chondrocyte p21WAF1/CIP1 Expression Is Increased by Dexamethasone but Does Not Contribute to Dexamethasone-Induced Growth Retardation In Vivo

C. Farquharson, S. Ahmed, H. Owen, 2009, Calcified Tissue International.

MMP and TIMP temporal gene expression during osteocytogenesis.

A. Pitsillides, C. Farquharson, K. Staines, 2015, Gene expression patterns : GEP.

Hypomorphic conditional deletion of E11/Podoplanin reveals a role in osteocyte dendrite elongation

A. Pitsillides, C. Farquharson, E. Ikpegbu, 2017, Journal of cellular physiology.

Cytokine actions in growth disorders associated with pediatric chronic inflammatory diseases (review).

C. Farquharson, V. Macrae, S. Ahmed, 2006, International journal of molecular medicine.

Insulin-like growth factor-I augments chondrocyte hypertrophy and reverses glucocorticoid-mediated growth retardation in fetal mice metatarsal cultures.

C. Farquharson, S. Ahmed, T. Mushtaq, 2004, Endocrinology.

Azathioprine Has a Deleterious Effect on the Bone Health of Mice with DSS-Induced Inflammatory Bowel Disease

C. Farquharson, C. Stevens, K. Staines, 2019, International journal of molecular sciences.

Conditional deletion of E11/Podoplanin in bone protects against ovariectomy-induced increases in osteoclast formation and activity

A. Pitsillides, C. Farquharson, R. Fleming, 2020, Bioscience reports.

Pathophysiology and management of abnormal growth in children with chronic inflammatory bowel disease.

R. Russell, C. Farquharson, S. Ahmed, 2013, World review of nutrition and dietetics.

Inflammation and linear bone growth: the inhibitory role of SOCS2 on GH/IGF-1 signaling

C. Farquharson, S. Ahmed, S. Ahmed, 2013, Pediatric Nephrology.

Social networking between cells of the foetal skeleton: the importance of thyroid hormones.

C. Farquharson, 2011, The Journal of endocrinology.

Altered Bone Development and an Increase in FGF-23 Expression in Enpp1−/− Mice

J. Millán, C. Farquharson, E. Milne, 2012, PloS one.

BMP-9 regulates the osteoblastic differentiation and calcification of vascular smooth muscle cells through an ALK1 mediated pathway

C. Farquharson, V. Macrae, C. Shanahan, 2014, Journal of cellular and molecular medicine.

Localisation and expression of TRPV6 in all intestinal segments and kidney of laying hens

C. Farquharson, J. Hou, Y. Yu, 2011, British poultry science.

MEPE is a novel regulator of growth plate cartilage mineralization

C. Farquharson, K. Staines, V. MacRae, 2012, Bone.

Inhibition of PHOSPHO1 activity results in impaired skeletal mineralization during limb development of the chick.

J. Millán, C. Farquharson, L. McTeir, 2010, Bone.

Edinburgh Research Explorer Skeletal energy homeostasis

K. Suchacki, F. Roberts, Andrea Lovdel, 2017 .

Suppression of mammalian bone growth by membrane transport inhibitors

A. Hall, C. Farquharson, P. Bush, 2013, Journal of cellular biochemistry.

The role of accelerated growth plate fusion in the absence of SOCS2 on osteoarthritis vulnerability

C. Farquharson, K. Staines, H. Samvelyan, 2021, bioRxiv.

Direct stimulation of bone mass by increased GH signalling in the osteoblasts of Socs2−/− mice

C. Farquharson, V. Macrae, S. Ahmed, 2014, The Journal of endocrinology.

Increased bone mass , altered trabecular architecture and modified growth plate organization in the growing skeleton of SOCS 2 deficient mice

C. Farquharson, S. Horvat, R. Collinson, 2013 .

Correction: Altered Bone Development and an Increase in FGF-23 Expression in Enpp1−/− Mice

J. Millán, C. Farquharson, E. Milne, 2012, PLoS ONE.

The growth plate sparing effects of the selective glucocorticoid receptor modulator, AL-438

C. Farquharson, S. Ahmed, H. Owen, 2007, Molecular and Cellular Endocrinology.

Distribution and quantification of pyridinium cross-links of collagen within the different maturational zones of the chick growth plate.

C. Farquharson, S. Robins, E. Seawright, 1996, Biochimica et biophysica acta.

Immunolocalization of collagen types I and III in the arterial wall of the rat

C. Farquharson, S. Robins, 1989, The Histochemical Journal.

The distribution of elastin in developing and adult rat organs using immunocytochemical techniques.

C. Farquharson, S. Robins, 1989, Journal of anatomy.

Edinburgh Research Explorer Extracellular Matrix Mineralization Promotes E 11 / gp 38 Glycoprotein Expression and Drives Osteocytic Differentiation

A. Pitsillides, C. Farquharson, N. Loveridge, 2017 .

Extracellular Matrix Mineralization Promotes E11/gp38 Glycoprotein Expression and Drives Osteocytic Differentiation

A. Pitsillides, C. Farquharson, N. Loveridge, 2012, PloS one.

Phospho1 deficiency transiently modifies bone architecture yet produces consistent modification in osteocyte differentiation and vascular porosity with ageing

J. Millán, C. Farquharson, P. Salmon, 2015, Bone.

The functional co-operativity of tissue-nonspecific alkaline phosphatase (TNAP) and PHOSPHO1 during initiation of skeletal mineralization.

C. Farquharson, M. C. Yadav, C. Huesa, 2015, Biochemistry and biophysics reports.

Kinetic Analysis of Substrate Utilization by Native and TNAP-, NPP1-, or PHOSPHO1-Deficient Matrix Vesicles

P. Ciancaglini, J. Millán, C. Farquharson, 2009, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Functional Involvement of PHOSPHO1 in Matrix Vesicle–Mediated Skeletal Mineralization

J. Millán, C. Farquharson, D. Harmey, 2007, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

PHOSPHO1-A novel phosphatase specifically expressed at sites of mineralisation in bone and cartilage.

C. Farquharson, A. Stewart, B. Houston, 2004, Bone.

Edinburgh Research Explorer Identification and cloning of a novel phosphatase expressed at high levels in differentiating growth plate chondrocytes

E. Hoogland, C. Farquharson, B. Houston, 2022 .

Tenascin-C is a driver of inflammation in the DSS model of colitis

C. Farquharson, G. Mclachlan, K. Midwood, 2022, Matrix biology plus.

Explorer Localisation and expression of TRPV 6 in all intestinal segments and kidney of laying hens

C. Farquharson, J. Hou, Y. Yu, 2017 .

Reference point indentation is not indicative of whole mouse bone measures of stress intensity fracture toughness

Jan L. Bruse, J. Millán, C. Farquharson, 2014, Bone.

Studies on growth plate chondrocytes in situ: cell proliferation and differentiation

C. Farquharson, N. Loveridge, 1993, Acta paediatrica (Oslo, Norway : 1992). Supplement.

Osteoblast‐specific deficiency of ectonucleotide pyrophosphatase or phosphodiesterase‐1 engenders insulin resistance in high‐fat diet fed mice

F. Roberts, C. Farquharson, V. Macrae, 2020, Journal of cellular physiology.

Ablation of Osteopontin Improves the Skeletal Phenotype of Phospho1−/− Mice

J. Millán, C. Farquharson, M. Hoylaerts, 2014, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Osteochondrosis/dyschondroplasia: a failure of chondrocyte differentiation

C. Farquharson, N. Loveridge, B. Thorp, 2010 .

The control of chondrocyte differentiation during endochondral bone growth in vivo: changes in TGF-beta and the proto-oncogene c-myc.

J. Hesketh, C. Farquharson, C. Whitehead, 1993, Journal of cell science.

Mitogenic action of insulin-like growth factor-I on human osteosarcoma MG-63 cells and rat osteoblasts maintained in situ: the role of glucose-6-phosphate dehydrogenase.

C. Farquharson, J. Milne, N. Loveridge, 1993, Bone and mineral.

A novel integral membrane protein is differentially expressed in the chick growth plate and maps to chromosome 1.

D. Burt, C. Farquharson, I. Paton, 1999, Animal genetics.

Glucocorticoid metabolism and the action of 11 beta-hydroxysteroid dehydrogenase 2 in canine congestive heart failure.

C. Farquharson, G. Markby, B. Corcoran, 2020, Veterinary journal.

Conditional deletion of E11/podoplanin in bone protects against load-induced osteoarthritis

A. Pitsillides, A. Amin, C. Farquharson, 2019, BMC Musculoskeletal Disorders.

Observations on the pancreas of cattle deficient in copper.

C. Farquharson, B. Fell, D. S. Graça, 1985, Journal of comparative pathology.

In vivo and in vitro effect of 1,25-dihydroxyvitamin D3 and 1,25-dihydroxy-16-ene-23-yne-vitamin D3 on the proliferation and differentiation of avian chondrocytes: their role in tibial dyschondroplasia.

C. Farquharson, C. Whitehead, N. Loveridge, 1996, The Journal of endocrinology.

Differentiation and mineralization in chick chondrocytes maintained in a high cell density culture: A model for endochondral ossification

C. Farquharson, C. Whitehead, 1995, In Vitro Cellular & Developmental Biology - Animal.

DIFFERENTIATION AND MINERALIZATION IN CHICK MAINTAINED IN A HIGH CELL DENSITY CULTURE: ENDOCHONDRAL OSSIFICATION CHONDROCYTES A MODEL FOR

C. Farquharson, C. Whitehead, 1995 .

The Expression of PHOSPHO1, nSMase2 and TNAP is Coordinately Regulated by Continuous PTH Exposure in Mineralising Osteoblast Cultures

C. Farquharson, K. Staines, V. Macrae, 2016, Calcified Tissue International.

Culture of Murine Embryonic Metatarsals: A Physiological Model of Endochondral Ossification

C. Farquharson, K. Staines, V. Macrae, 2016, Journal of visualized experiments : JoVE.

Growth and the Growth Hormone-Insulin Like Growth Factor 1 Axis in Children With Chronic Inflammation: Current Evidence, Gaps in Knowledge, and Future Directions.

C. Farquharson, S. C. Wong, G. Werther, 2016, Endocrine reviews.

A cell shrinkage artefact in growth plate chondrocytes with common fixative solutions: importance of fixative osmolarity for maintaining morphology.

A. Hall, C. Farquharson, P. Bush, 2010, European cells & materials.

The presence of PHOSPHO1 in matrix vesicles and its developmental expression prior to skeletal mineralization.

C. Farquharson, A. Stewart, R. Fleming, 2006, Bone.

Perspective on Dentoalveolar Manifestations Resulting From PHOSPHO1 Loss-of-Function: A Form of Pseudohypophosphatasia?

J. Millán, C. Farquharson, B. Foster, 2022, Frontiers in Dental Medicine.

Endocrine role of bone: recent and emerging perspectives beyond osteocalcin.

C. Farquharson, V. MacRae, Karla J. Oldknow, 2015, The Journal of endocrinology.

PHOSPHO1 is essential for normal bone fracture healing

J. Millán, C. Farquharson, J. Li, 2018, Bone & joint research.

Further Observations on Programmed Cell Death in the Epiphyseal Growth Plate: Comparison of Normal and Dyschondroplastic Epiphyses

C. Farquharson, I. Shapiro, C. Whitehead, 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Characterisation of matrix vesicles in skeletal and soft tissue mineralisation.

C. Farquharson, V. MacRae, L. Cui, 2016, Bone.

An Investigation of the Mineral in Ductile and Brittle Cortical Mouse Bone

A. Boyde, E. Saiz, J. Millán, 2015, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Skeletal development in the meat-type chicken

D. Waddington, C. Farquharson, S. Solomon, 2000, British poultry science.

PHOSPHO1 is essential for mechanically competent mineralization and the avoidance of spontaneous fractures.

Simon R. Goodyear, R. Aspden, J. Millán, 2010, Bone.

Chondrocytes and longitudinal bone growth: the development of tibial dyschondroplasia.

C. Farquharson, D. Jefferies, 2000, Poultry science.

Expression patterns of chondrocyte genes cloned by differential display in tibial dyschondroplasia.

C. Farquharson, B. Thorp, B. Houston, 2000, Biochimica et biophysica acta.

Cloning differentially regulated genes from chondrocytes using agarose gel differential display.

C. Farquharson, B. Thorp, B. Houston, 1998, Biochimica et biophysica acta.

Transcriptomic profiling of feline teeth highlights the role of matrix metalloproteinase 9 (MMP9) in tooth resorption

C. Farquharson, S. Lee, G. Bergkvist, 2020, Scientific Reports.

Bone Strength During Growth: Influence of Growth Rate on Cortical Porosity and Mineralization

D. Waddington, D. Waddington, C. Farquharson, 2004, Calcified Tissue International.

How To Build a Bone: PHOSPHO1, Biomineralization, and Beyond

J. Millán, C. Farquharson, K. Staines, 2019, JBMR plus.

Deer antler does not represent a typical endochondral growth system: immunoidentification of collagen type X but little collagen type II in growing antler tissue.

C. Farquharson, S. Robins, G. Rucklidge, 1997, Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology.

Interaction between dietary 1,25-dihydroxycholecalciferol and calcium and effects of management on the occurrence of tibial dyschondroplasia, leg abnormalities and performance in broiler chickens.

C. Farquharson, J. Berry, E. Mawer, 1995, British poultry science.

Avian tibial dyschondroplasia: the interaction of genetic selection and dietary 1,25-dihydroxycholecalciferol.

C. Farquharson, C. Whitehead, B. Ducro, 1993, Avian pathology : journal of the W.V.P.A.

Expression of type X collagen, Indian hedgehog and parathyroid hormone related-protein in normal and tibial dyschondroplastic chick growth plates

S. V. Webster, C. Farquharson, A. Kwan, 2003, Avian pathology : journal of the W.V.P.A.

FGF‐2 promotes osteocyte differentiation through increased E11/podoplanin expression

A. Pitsillides, C. Farquharson, E. Ikpegbu, 2018, Journal of cellular physiology.

Cell proliferation and enzyme activities associated with the development of avian tibial dyschondroplasia: an in situ biochemical study.

C. Farquharson, C. Whitehead, N. Loveridge, 1992, Bone.

C. Farquharson, B. Houston, E. Seawright, 2022 .

Parathyroid hormone-related peptide expression in tibial dyschondroplasia

C. Farquharson, E. Seawright, D. Jefferies, 2001, Avian pathology : journal of the W.V.P.A.

Loss of Skeletal Mineralization by the Simultaneous Ablation of PHOSPHO1 and Alkaline Phosphatase Function: A Unified Model of the Mechanisms of Initiation of Skeletal Calcification

M. McKee, J. Millán, C. Farquharson, 2010, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Pharmacological inhibition of PHOSPHO1 suppresses vascular smooth muscle cell calcification

B. Stec, J. Millán, N. Cosford, 2013, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Identification of novel regulators of osteoblast matrix mineralization by time series transcriptional profiling

C. Farquharson, V. Macrae, K. Staines, 2014, Journal of Bone and Mineral Metabolism.

Design, synthesis and evaluation of benzoisothiazolones as selective inhibitors of PHOSPHO1.

J. Millán, E. Sergienko, N. Cosford, 2014, Bioorganic & medicinal chemistry letters.

Sodium fluoride induces apoptosis and alters bcl-2 family protein expression in MC3T3-E1 osteoblastic cells.

C. Farquharson, B. Han, Rashad Alkasir, 2011, Biochemical and biophysical research communications.

The role of sex steroids in controlling pubertal growth

C. Farquharson, S. F. Ahmed, S. F. Ahmed, 2008, Clinical endocrinology.

Phospholipase C-eta Enzymes as Putative Protein Kinase C and Ca2+ Signalling Components in Neuronal and Neuroendocrine Tissues

C. Farquharson, K. Morgan, R. Millar, 2007, Neuroendocrinology.

Identification of a novel class of mammalian phosphoinositol-specific phospholipase C enzymes.

C. Farquharson, Joyita Mukherjee, A. Stewart, 2005, International journal of molecular medicine.

The role of miR‐29 family in disease

C. Farquharson, L. Stephen, M. Horita, 2021, Journal of cellular biochemistry.

Ablation of Enpp6 Results in Transient Bone Hypomineralization

K. Suchacki, C. Farquharson, W. Cawthorn, 2020, JBMR plus.

The Effects of Copper Deficiency on the Pyridinium Crosslinks of Mature Collagen in the Rat Skeleton and Cardiovascular System

C. Farquharson, S. Robins, A. Duncan, 1989, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

The Effects of Reserpine upon the Cardiac Enlargement of Copper Deficiency

C. Farquharson, C. Lawrence, 1988, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

Female Rats Are Susceptible to Cardiac Hypertrophy Induced by Copper Deficiency: The Lack of Influence of Estrogen and Testosterone

C. Farquharson, S. Robins, 1988, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

Immunolocalization of collagen types I, III and IV, elastin and fibronectin within the heart of normal and copper-deficient rats.

C. Farquharson, S. Robins, 1991, Journal of comparative pathology.

miR-29b inhibits TGF-β1-induced cell proliferation in articular chondrocytes

C. Farquharson, A. Raper, L. Stephen, 2022, Biochemistry and biophysics reports.

Alterations in glycosaminoglycan concentration and sulfation during chondrocyte maturation

C. Farquharson, C. Whitehead, N. Loveridge, 1994, Calcified Tissue International.

Extracellular fatty acid binding protein (Ex-FABP) modulation by inflammatory agents: "physiological" acute phase response in endochondral bone formation.

R. Cancedda, C. Farquharson, S. Cermelli, 2000, European journal of cell biology.

ENPP1 in the Regulation of Mineralization and Beyond.

F. Roberts, C. Farquharson, V. Macrae, 2019, Trends in biochemical sciences.

Gene Therapy Using Recombinant AAV Type 8 Vector Encoding TNAP‐D10 Improves the Skeletal Phenotypes in Murine Models of Osteomalacia

J. Millán, C. Farquharson, K. Miyake, 2022, JBMR plus.

Genetic selection for fast growth generates bone architecture characterised by enhanced periosteal expansion and limited consolidation of the cortices but a diminution in the early responses to mechanical loading.

A. Pitsillides, C. Farquharson, L. Saxon, 2009, Bone.

Endochondral Growth Defect and Deployment of Transient Chondrocyte Behaviors Underlie Osteoarthritis Onset in a Natural Murine Model

A. Pitsillides, A. Bodey, C. Farquharson, 2016, Arthritis & rheumatology.

Effects of choice of reverse-transcriptase enzyme and use of T4 gene 32 protein on banding patterns in agarose gel differential display.

C. Farquharson, D. Jefferies, 2002, Analytical biochemistry.

Identification of a family of noncanonical ubiquitin-conjugating enzymes structurally related to yeast UBC6.

C. Farquharson, B. Houston, D. Lester, 2000, Biochemical and biophysical research communications.

Identification of a novel splice variant of the haloacid dehalogenase: PHOSPHO1.

C. Farquharson, H. Owen, S. J. Roberts, 2008, Biochemical and biophysical research communications.

Probing the substrate specificities of human PHOSPHO1 and PHOSPHO2.

P. Sadler, C. Farquharson, R. Schmid, 2005, Biochimica et biophysica acta.

In vivo effect of 1,25‐dihydroxycholecalciferol on the proliferation and differentiation of avian chondrocytes

C. Farquharson, C. Whitehead, N. Loveridge, 1993, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Beyond mineralisation: metabolic functions for matrix mineralisation regulators.

F. Roberts, C. Farquharson, V. Macrae, 2020, The Journal of endocrinology.

Enhanced phosphocholine metabolism is essential for terminal erythropoiesis.

J. Millán, C. Farquharson, C. Lewis, 2018, Blood.

Explorer Increased Linear Bone Growth by GH in the Absence of SOCS 2 is Independent of IGF-1

C. Farquharson, V. Macrae, S. Jasim, 2017 .

Increased linear bone growth by GH in the absence of SOCS2 is independent of IGF‐1

C. Farquharson, V. Macrae, S. Jasim, 2015, Journal of cellular physiology.

Immunohistochemical localization of native and denatured collagen types I and II in fetal and adult rat long bones.

C. Farquharson, S. Robins, G. Rucklidge, 1988, Bone.

A Systems-Level Analysis of Total-Body PET Data Reveals Complex Skeletal Metabolism Networks in vivo

T. Freeman, K. Suchacki, C. Farquharson, 2021, Frontiers in Medicine.

Excretion of pyridinium cross-links of collagen in ovariectomized rats as urinary markers for increased bone resorption

C. Farquharson, S. Robins, D. Black, 1989, Calcified Tissue International.

A comparison of the bone and growth phenotype of mdx, mdx:Cmah−/− and mdx:Utrn+/− murine models with the C57BL/10 wild-type mouse

K. Suchacki, C. Farquharson, W. Cawthorn, 2019, Disease Models & Mechanisms.

Piroxicam Treatment Augments Bone Abnormalities in Interleukin-10 Knockout Mice

A. K. Hansen, C. Farquharson, S. F. Ahmed, 2015, Inflammatory bowel diseases.

A protective role for FGF-23 in local defence against disrupted arterial wall integrity?

J. Millán, C. Farquharson, V. Macrae, 2013, Molecular and Cellular Endocrinology.

Exploiting novel valve interstitial cell lines to study calcific aortic valve disease

C. Farquharson, V. Macrae, K. Summers, 2017, Molecular medicine reports.

Compounded PHOSPHO1/ALPL Deficiencies Reduce Dentin Mineralization

M. McKee, C. Farquharson, M. Somerman, 2013, Journal of dental research.

Bone Research Society, Annual Meeting 2017 Proceedings

P. Tsai, T. Spector, J. Bell, 2018, Journal of musculoskeletal & neuronal interactions.

Role of PHOSPHO1 in Periodontal Development and Function

C. Farquharson, M. Somerman, B. Foster, 2016, Journal of dental research.

Skeletal Mineralization Deficits and Impaired Biogenesis and Function of Chondrocyte‐Derived Matrix Vesicles in Phospho1–/– and Phospho1/Pit1 Double‐Knockout Mice

B. Fadeel, J. Millán, C. Farquharson, 2016, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

A distinctive patchy osteomalacia characterises Phospho1‐deficient mice

A. Boyde, A. Pitsillides, J. Millán, 2017, Journal of anatomy.

A distinctive patchy osteomalacia characterises Phospho1‐deficient mice

A. Boyde, A. Pitsillides, J. Millán, 2017, Journal of Anatomy.

compounded ph Osph O1/ AL p L Deficiencies r educe Dentin Mineralization

A. Act, M. McKee, C. Farquharson, 2013 .

Increased PHOSPHO1 and alkaline phosphatase expression during the anabolic bone response to intermittent parathyroid hormone delivery

A. Pitsillides, J. Millán, C. Farquharson, 2022, Cell biochemistry and function.

Quantitative atomic force microscopy provides new insight into matrix vesicle mineralization.

S. Esener, P. Ciancaglini, J. Millán, 2019, Archives of biochemistry and biophysics.

End stage renal disease‐induced hypercalcemia may promote aortic valve calcification via Annexin VI enrichment of valve interstitial cell derived‐matrix vesicles

M. Dweck, D. Newby, C. Farquharson, 2017, Journal of cellular physiology.

Upregulation of IGF2 expression during vascular calcification.

J. Millán, C. Farquharson, Dongxing Zhu, 2014, Journal of molecular endocrinology.

The Expression of PHOSPHO1, nSMase2 and TNAP is Coordinately Regulated by Continuous PTH Exposure in Mineralising Osteoblast Cultures

C. Farquharson, V. Macrae, K. Staines, 2016, Calcified Tissue International.

Hypomineralisation drives joint instability and osteoarthritis in mice

A. Pitsillides, J. Millán, C. Farquharson, 2016 .

Chromosomal localization of the chicken and mammalian orthologues of the orphan phosphatase PHOSPHO1 gene.

D. Burt, D. Burt, C. Farquharson, 2002, Animal genetics.

Cartilage to bone transitions in health and disease

A. Pollard, I. McGonnell, A. Pitsillides, 2013, The Journal of endocrinology.

1 Identification of a novel splice variant of the haloacid dehalogenase-PHOSPHO 1

C. Farquharson, H. Owen, S. Roberts, 2013 .

Isolation and Characterization of Primary Rat Valve Interstitial Cells: A New Model to Study Aortic Valve Calcification

C. Farquharson, V. Macrae, G. Markby, 2017, Journal of visualized experiments : JoVE.

The expression of transforming growth factor-beta by cultured chick growth plate chondrocytes: differential regulation by 1,25-dihydroxyvitamin D3.

D. Burt, A. Law, C. Farquharson, 1996, The Journal of endocrinology.

Spatial Lipidomic Profiling of Mouse Joint Tissue Demonstrates the Essential Role of PHOSPHO1 in Growth Plate Homeostasis

C. Farquharson, C. De Bari, L. Stephen, 2023, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

P9. Control of chondrocyte maturation: role of glycosaminoglycans, c-myc and TGFβ in the development of avian tibial dyschondroplasia

C. Farquharson, C. Whitehead, N. Loveridge, 1992 .

P7. Stimulation of bone cell activity by insulin like growth factor-I

C. Farquharson, N. Loveridge, 1990 .

Bones and Cartilage: Developmental and Evolutionary Skeletal Biology. Second Edition

C. Farquharson, 2015, British poultry science.

Evaluating invasive and non-invasive methods to determine fat content in the laboratory mouse

L. Bünger, C. Farquharson, V. MacRae, 2015 .

The Ex Vivo Organ Culture of Bone.

C. Farquharson, K. Staines, Genevieve N. Brown, 2019, Methods in molecular biology.

Cytokine profiling and in vitro studies of murine bone growth using biological fluids from children with juvenile idiopathic arthritis

C. Farquharson, I. McInnes, V. MacRae, 2007, Clinical endocrinology.

Hypomorphic conditional deletion of E11/podoplanin in the subchondral bone protects against load-induced osteoarthritis

A. Pitsillides, A. Amin, C. Farquharson, 2018 .

Functional involvement of PHOSPHO1 in matrix vesicle-mediated skeletal mineralization.

J. Millán, C. Farquharson, D. Harmey, 2007, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Identification and cloning of a novel phosphatase expressed at high levels in differentiating growth plate chondrocytes

C. Farquharson, B. Houston, E. Seawright, 1999 .

Intravesicular Phosphatase PHOSPHO1 Function in Enamel Mineralization and Prism Formation

J. Wingfield, T. Diekwisch, J. Pérez, 2017, Front. Physiol..

Increased bone mass, altered trabecular architecture and modified growth plate organization in the growing skeleton of SOCS2 deficient mice

A. Pitsillides, C. Farquharson, S. Horvat, 2009, Journal of cellular physiology.

Functional involvement of PHOSPHO1 in matrix vesicle-mediated skeletal mineralization.

J. Millán, C. Farquharson, D. Harmey, 2007, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Identification of novel regulators of osteoblast matrix mineralization by time series transcriptional profiling

C. Farquharson, K. Staines, Dongxing Zhu, 2013 .

The effect of GH and IGF1 on linear growth and skeletal development and their modulation by SOCS proteins.

C. Farquharson, S. F. Ahmed, 2010, The Journal of endocrinology.

A protective role for FGF-23 in local defence against disrupted arterial wall integrity?

J. Millán, C. Farquharson, V. Macrae, 2013, Molecular and Cellular Endocrinology.

Enhanced phosphocholine metabolism is essential for terminal erythropoiesis.

J. Millán, C. Farquharson, C. Lewis, 2018, Blood.

Edinburgh Research Explorer Endochondral growth defect and deployment of transient chondrocyte behaviours underlie osteoarthritis onset in a natural murine model

C. Farquharson, K. Staines, B. Poulet, 2015 .

Dmp1 Promoter-Driven Diphtheria Toxin Receptor Transgene Expression Directs Unforeseen Effects in Multiple Tissues

A. Boyde, A. Pitsillides, C. Scudamore, 2016, International journal of molecular sciences.

The Appearance and Modulation of Osteocyte Marker Expression during Calcification of Vascular Smooth Muscle Cells

J. Millán, C. Farquharson, V. Macrae, 2011, PloS one.

The presence of PHOSPHO1 in matrix vesicles and its developmental expression prior to skeletal mineralization.

C. Farquharson, R. Fleming, S. Roberts, 2006, Bone.

A distinctive patchy osteomalacia characterises Phospho1‐deficient mice

A. Boyde, A. Pitsillides, J. Millán, 2017, Journal of anatomy.

Pharmacological inhibition of PHOSPHO1 suppresses vascular smooth muscle cell calcification

B. Stec, J. Millán, N. Cosford, 2013, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

The importance of the SIBLING family of proteins on skeletal mineralisation and bone remodelling.

C. Farquharson, V. Macrae, K. Staines, 2012, The Journal of endocrinology.

Identification of a novel splice variant of the haloacid dehalogenase: PHOSPHO1.

C. Farquharson, S. J. Roberts, Helen C. Owen, 2008, Biochemical and biophysical research communications.

Anti-RANKL Therapy Prevents Glucocorticoid-Induced Bone Loss and Promotes Muscle Function in a Mouse Model of Duchenne Muscular Dystrophy

C. Farquharson, S. C. Wong, A. Argaw, 2023, Calcified Tissue International.

Mechanisms and Clinical Consequences of Vascular Calcification

C. Farquharson, V. Macrae, Dongxing Zhu, 2012, Front. Endocrin..