Giulia Chemi

发表

Identification of novel fluorescent probes preventing PrPSc replication in prion diseases.

Simone Brogi, Giuseppe Legname, Giulia Chemi, 2017, European journal of medicinal chemistry.

Computer-Driven Development of an in Silico Tool for Finding Selective Histone Deacetylase 1 Inhibitors

Simone Brogi, Giulia Chemi, G. Campiani, 2020, Molecules.

Structural characterization of Giardia duodenalis thioredoxin reductase (gTrxR) and computational analysis of its interaction with NBDHEX.

Simone Brogi, Giulia Chemi, Giuseppe Campiani, 2017, European journal of medicinal chemistry.

Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, Synthesis, Structural Analysis, and Biological Evaluation.

L. Altucci, J. O’Sullivan, Simone Brogi, 2020, ACS medicinal chemistry letters.

Identification of Novel 3-Hydroxy-pyran-4-One Derivatives as Potent HIV-1 Integrase Inhibitors Using in silico Structure-Based Combinatorial Library Design Approach

A. Fassihi, L. Saghaie, Simone Brogi, 2019, Front. Chem..

Amyloid β fibril disruption by oleuropein aglycone: long-time molecular dynamics simulation to gain insight into the mechanism of action of this polyphenol from extra virgin olive oil.

Simone Brogi, Giulia Chemi, Hajar Sirous, 2020, Food & function.

( S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: Further Exploration of Bioisosteric Replacements and Structural and Biological Investigation.

Simone Brogi, Ettore Novellino, Mikko Gynther, 2018, Journal of medicinal chemistry.

A Jocic-type approach for a practical and scalable synthesis of pyrrolonaphthoxazepine (PNOX)-based potent proapoptotic agents

E. Novellino, Simone Brogi, M. Brindisi, 2018, Tetrahedron Letters.

Screening and phenotypical characterization of Schistosoma mansoni histone deacetylase 8 (SmHDAC8) inhibitors as multi-stage antischistosomal agents.

Simone Brogi, M. Brindisi, S. Gemma, 2020, ACS infectious diseases.

Synthetic studies toward bicyclic endoperoxides presenting polar side chains

E. Novellino, Simone Brogi, M. Brindisi, 2018, Tetrahedron Letters.

Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]-N-[(piperidin-4-yl)methyl]methanamine (MMV019918) and analogues.

Silvia Parapini, Donatella Taramelli, Simone Brogi, 2018, European journal of medicinal chemistry.

Synthesis, Molecular Modelling and Biological Studies of 3-hydroxy-pyrane-4-one and 3-hydroxy-pyridine-4-one Derivatives as HIV-1 Integrase Inhibitors.

Zeger Debyser, Afshin Fassihi, Simone Brogi, 2019, Medicinal chemistry (Shariqah (United Arab Emirates)).

Bridged bicyclic 2,3-dioxabicyclo[3.3.1]nonanes as antiplasmodial agents: Synthesis, structure-activity relationships and studies on their biomimetic reaction with Fe(II).

E. Novellino, D. Taramelli, Simone Brogi, 2019, Bioorganic chemistry.

Multiple unbiased approaches identify oxidosqualene cyclase as the molecular target of a promising anti-leishmanial

I. Gilbert, A. Fairlamb, M. Ferguson, 2021, Cell chemical biology.

An integrated in silico screening strategy for identifying promising disruptors of p53-MDM2 interaction

Simone Brogi, Hajar Sirous, Giulia Chemi, 2019, Comput. Biol. Chem..

Selective Fatty Acid Amide Hydrolase Inhibitors as Potential Novel Antiepileptic Agents.

G. Di Giovanni, Simone Brogi, S. Gemma, 2021, ACS chemical neuroscience.

A light in the dark: state of the art and perspectives in optogenetics and optopharmacology for restoring vision.

Simone Brogi, Giulia Chemi, Giuseppe Campiani, 2019, Future medicinal chemistry.

Development of novel multipotent compounds modulating endocannabinoid and dopaminergic systems.

E. Novellino, Simone Brogi, M. Brindisi, 2019, European journal of medicinal chemistry.

Novel quinolone-based potent and selective HDAC6 inhibitors: Synthesis, molecular modeling studies and biological investigation.

L. Altucci, Simone Brogi, M. Brindisi, 2020, European journal of medicinal chemistry.

Cinnamides Target Leishmania amazonensis Arginase Selectively

Simone Brogi, Giulia Chemi, G. Campiani, 2020, Molecules.

Novel spiroindoline HDAC inhibitors: Synthesis, molecular modelling and biological studies.

Christophe Romier, Simone Brogi, Lucia Altucci, 2018, European journal of medicinal chemistry.

Activation of the Wnt Pathway by Small Peptides: Rational Design, Synthesis and Biological Evaluation

E. Novellino, Simone Brogi, M. Brindisi, 2017, ChemMedChem.

Harnessing the Role of HDAC6 in Idiopathic Pulmonary Fibrosis: Design, Synthesis, Structural Analysis, and Biological Evaluation of Potent Inhibitors.

A. Prasse, L. Altucci, E. Bargagli, 2021, Journal of medicinal chemistry.

The ionotropic glutamate receptor GluA2 in complex with bicyclic pyrimidinedione-based compounds: when small compound modifications have distinct effects on binding interactions.

J. Kastrup, Simone Brogi, S. Gemma, 2020, ACS chemical neuroscience.

A Repurposing Approach for Uncovering the Anti-Tubercular Activity of FDA-Approved Drugs with Potential Multi-Targeting Profiles

Simone Brogi, S. Gemma, Giulia Chemi, 2019, Molecules.

Synthesis, biological evaluation and molecular modeling of novel selective COX-2 inhibitors: sulfide, sulfoxide, and sulfone derivatives of 1,5-diarylpyrrol-3-substituted scaffold.

C. La Motta, Simone Brogi, Giulia Chemi, 2019, Bioorganic & medicinal chemistry.

Computational Tool for Fast in silico Evaluation of hERG K+ Channel Affinity

Simone Brogi, Giulia Chemi, Giuseppe Campiani, 2017, Front. Chem..

First dual AK/GSK-3β inhibitors endowed with antioxidant properties as multifunctional, potential neuroprotective agents.

Simone Brogi, Giulia Chemi, Giuseppe Campiani, 2017, European journal of medicinal chemistry.

Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents.

E. Novellino, M. Steinmetz, L. Altucci, 2019, European journal of medicinal chemistry.

Design, synthesis and biological evaluation of 7-substituted 4-phenyl-6H-imidazo[1,5-a]thieno[3,2-f] [1,4]diazepines as safe anxiolytic agents.

R. Matucci, Simone Brogi, Giulia Chemi, 2020, European journal of medicinal chemistry.

Identification of novel fluorescent probes preventing PrPSc replication in prion diseases.

L. Zaccagnini, Simone Brogi, M. Brindisi, 2017, European journal of medicinal chemistry.

Breakthroughs in Computational Approaches for Drug Discovery

Simone Brogi, Giulia Chemi, Simone Brogi, 2017 .