J. Fujii

N. Taniguchi, J. Fujii, Motoko Takahashi, 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

A pivotal role of Zn-binding residues in the function of the copper chaperone for SOD1.

N. Taniguchi, J. Fujii, Kenzo Sato, 2000, Biochemical and biophysical research communications.

Dysfunction of antioxidative enzymes in the trinitrobenzenesulfonic acid-induced colitis rat

Keiichiro Suzuki, N. Taniguchi, J. Fujii, 1998 .

Characterization of Wild‐Type and Amyotrophic Lateral Sclerosis‐Related Mutant Cu,Zn‐Superoxide Dismutases Overproduced in Baculovirus‐Infected Insect Cells

Y. Ikeda, N. Taniguchi, J. Fujii, 1995, Journal of neurochemistry.

An SOD1 deficiency aggravates proteasome inhibitor bortezomib-induced testicular damage in mice.

T. Homma, J. Fujii, 2019, Biochimica et biophysica acta. General subjects.

Oxidative stress triggers lipid droplet accumulation in primary cultured hepatocytes by activating fatty acid synthesis.

T. Homma, Jaeyong Lee, T. Kurahashi, 2015, Biochemical and biophysical research communications.

γ-Glutamylcysteine synthetase and γ-glutamyl transferase as differential enzymatic sources of γ-glutamylpeptides in mice

Y. Ikeda, J. Fujii, Sho Kobayashi, 2020, Amino Acids.

The viability of primary hepatocytes is maintained under a low cysteine‐glutathione redox state with a marked elevation in ophthalmic acid production

T. Homma, Jaeyong Lee, E. S. Kang, 2017, Experimental cell research.

Immunohistochemical Study of Glutathione Reductase in Rat Ocular Tissues at Different Developmental Stages

H. Yamashita, N. Taniguchi, J. Fujii, 2001, The Histochemical Journal.

Differential Expression of Glutathione Reductase and Cytosolic Glutathione Peroxidase, GPX1, in Developing Rat Lungs and Kidneys

N. Taniguchi, J. Fujii, T. Fujii, 2002, Free radical research.

Alteration of Glutathione Reductase Expression in the Female Reproductive Organs During the Estrous Cycle1

J. Fujii, H. Kurachi, T. Fujii, 2001, Biology of reproduction.

Induction and release of manganese superoxide dismutase from mitochondria of human umbilical vein endothelial cells by tumor necrosis factor‐α and interleukin‐1α

Keiichiro Suzuki, N. Taniguchi, J. Fujii, 1993 .

Induction and release of manganese superoxide dismutase from mitochondria of human umbilical vein endothelial cells by tumor necrosis factor-alpha and interleukin-1 alpha.

N. Taniguchi, J. Fujii, K. Suzuki, 1993, International journal of cancer.

Enhancement of hepatitis‐B surface‐antigen expression by 5‐azacytidine in a hepatitis‐B‐virus‐transfected cell line

N. Hayashi, H. Fusamoto, T. Kamada, 1992, International journal of cancer.

Overexpression of the aldose reductase gene induces apoptosis in pancreatic beta-cells by causing a redox imbalance.

Y. Matsuzawa, Y. Yamasaki, M. Takahashi, 1999, Journal of biochemistry.

Induction of apoptotic cell death by methylglyoxal and 3-deoxyglucosone in macrophage-derived cell lines.

M. Takahashi, N. Taniguchi, J. Fujii, 1996, Biochemical and biophysical research communications.

Heat stress promotes the down-regulation of IRE1α in cells: An atypical modulation of the UPR pathway.

T. Homma, J. Fujii, 2016, Experimental Cell Research.

Cysteine preservation confers resistance to glutathione-depleted cells against ferroptosis via CDGSH iron sulphur domain-containing proteins (CISDs)

T. Homma, J. Fujii, Sho Kobayashi, 2020, Free radical research.

The role of the skeletal muscle ryanodine receptor gene in malignant hyperthermia.

M. Phillips, B. Britt, A. Archibald, 1992, Symposia of the Society for Experimental Biology.

Suppression of antioxidative enzyme expression by transforming growth factor-beta 1 in rat hepatocytes.

Y. Matsuzawa, N. Taniguchi, J. Fujii, 1994, The Journal of biological chemistry.

Reducing sugars trigger oxidative modification and apoptosis in pancreatic beta-cells by provoking oxidative stress through the glycation reaction.

Keiichiro Suzuki, H. Kaneto, Y. Yamasaki, 1996, The Biochemical journal.

Glutathione reductase is expressed at high levels in pancreatic islet cells

Y. Ikeda, J. Fujii, Y. Iuchi, 2004, Redox report : communications in free radical research.

Rescue of anaemia and autoimmune responses in SOD1-deficient mice by transgenic expression of human SOD1 in erythrocytes.

M. Suematsu, T. Soga, O. Nakajima, 2009, The Biochemical journal.

Deficiency of the cystine-transporter gene, xCT, does not exacerbate the deleterious phenotypic consequences of SOD1 knockout in mice

J. Fujii, Hideyo Sato, S. Bannai, 2008, Molecular and Cellular Biochemistry.

Elevated oxidative stress in erythrocytes due to a SOD1 deficiency causes anaemia and triggers autoantibody production.

H. Asao, J. Fujii, F. Okada, 2007, The Biochemical journal.

Deterioration of ischemia/reperfusion-induced acute renal failure in SOD1-deficient mice

Y. Tomita, J. Fujii, F. Okada, 2007, Free radical research.

Accelerated impairment of spermatogenic cells in sod1-knockout mice under heat stress

Y. Ikeda, Y. Tomita, J. Fujii, 2005, Free radical research.

[11] Regulation of Ca2+-pump from cardiac sarcoplasmic reticulum

J. Fujii, M. Inui, M. Tada, 1988 .

TGF-beta1 triggers oxidative modifications and enhances apoptosis in HIT cells through accumulation of reactive oxygen species by suppression of catalase and glutathione peroxidase.

H. Kaneto, N. Taniguchi, J. Fujii, 1997, Free radical biology & medicine.

Complete complementary DNA-derived amino acid sequence of canine cardiac phospholamban.

J. Fujii, S. Tanaka, M. Tada, 1987, The Journal of clinical investigation.

Nrf 2-regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress

C. Harvey, J. Fujii, R. Thimmulappa, 2009 .

A new variant Cu/Zn superoxide dismutase (Val7-->Glu) deduced from lymphocyte mRNA sequences from Japanese patients with familial amyotrophic lateral sclerosis.

N. Taniguchi, J. Fujii, Y. Nagai, 1994, Biochemical and biophysical research communications.

The SOD1 transgene expressed in erythroid cells alleviates fatal phenotype in congenic NZB/NZW-F1 mice

T. Homma, Jaeyong Lee, N. Otsuki, 2016, Free radical research.

Reactive oxygen species enhances the induction of inducible nitric oxide synthase by sphingomyelinase in RAW264.7 cells.

T. Watanabe, N. Taniguchi, J. Fujii, 1998, Biochimica et biophysica acta.

A high expression of heme oxygenase-1 in the liver of LEC rats at the stage of hepatoma: the possible implication of induction in uninvolved tissue.

N. Taniguchi, J. Fujii, K. Suzuki, 1998, Free radical research.

Shiga toxin binds to activated platelets

J. Fujii, R. Polanowska-Grabowska, T. Obrig, 2004, Journal of thrombosis and haemostasis : JTH.

Inactivation of cysteine and serine proteases by singlet oxygen.

Y. Ikeda, J. Fujii, Y. Iuchi, 2007, Archives of biochemistry and biophysics.

Involvement of Glycation and Oxidative Stress in Diabetic Macroangiopathy

Keiichiro Suzuki, H. Kaneto, J. Fujii, 1996, Diabetes.

Unveiling systemic organ disorders associated with impaired lipid catabolism in fasted SOD1-deficient mice.

T. Homma, Jaeyong Lee, J. Fujii, 2018, Archives of biochemistry and biophysics.

A high-fat diet temporarily renders Sod1-deficient mice resistant to an oxidative insult.

T. Homma, Jaeyong Lee, Junitsu Ito, 2017, The Journal of nutritional biochemistry.

An SOD1 deficiency enhances lipid droplet accumulation in the fasted mouse liver by aborting lipophagy.

T. Homma, Jaeyong Lee, T. Kurahashi, 2015, Biochemical and biophysical research communications.

Ascorbic acid and CoQ10 ameliorate the reproductive ability of superoxide dismutase 1-deficient female mice†

T. Homma, Jaeyong Lee, J. Fujii, 2019, Biology of Reproduction.

Protective role of testis-specific peroxiredoxin 4 against cellular oxidative stress

T. Kurahashi, J. Fujii, T. Utsumi, 2017, Journal of clinical biochemistry and nutrition.

Genetic ablation of aldehyde reductase (Akr1a) augments exercise endurance in mice via activation of the PGC-1α-involved pathway.

T. Homma, O. Nakajima, J. Fujii, 2020, Life sciences.

Apoptotic Cell Death Triggered by Nitric Oxide in Pancreatic β-Cells

Keiichiro Suzuki, H. Kaneto, Y. Yamasaki, 1995, Diabetes.

Reducing Sugars Induce Apoptosis in Pancreatic β-Cells by Provoking Oxidative Stress via a Glycation Reaction

Keiichiro Suzuki, H. Kaneto, N. Taniguchi, 2005 .

Redox capacity of cells affects inactivation of glutathione reductase by nitrosative stress.

N. Taniguchi, J. Fujii, T. Fujii, 2000, Archives of biochemistry and biophysics.

Characterization of cDNA and genomic DNA encoding SERCA1, the Ca(2+)-ATPase of human fast-twitch skeletal muscle sarcoplasmic reticulum, and its elimination as a candidate gene for Brody disease.

M. Phillips, J. Fujii, D. Cornblath, 1995, Genomics.

Generation of Rat Monoclonal Antibody for Mouse Nucleolin by Immunization of Ferroptosis-Induced Hepa 1-6 Cells.

J. Fujii, T. Tachibana, Sho Kobayashi, 2022, Monoclonal antibodies in immunodiagnosis and immunotherapy.

Flow cytometric determination of ferroptosis using a rat monoclonal antibody raised against ferroptotic cells.

T. Homma, J. Fujii, C. Yokoyama, 2022, Journal of immunological methods.

Methionine Deprivation Reveals the Pivotal Roles of Cell Cycle Progression in Ferroptosis That Is Induced by Cysteine Starvation

T. Homma, J. Fujii, Sho Kobayashi, 2022, Cells.

d-Cysteine supplementation partially protects against ferroptosis induced by xCT dysfunction via increasing the availability of glutathione

T. Homma, J. Fujii, Hideyo Sato, 2022, Journal of clinical biochemistry and nutrition.

Ascorbate is a multifunctional micronutrient whose synthesis is lacking in primates

J. Fujii, 2021, Journal of clinical biochemistry and nutrition.

Superoxide produced by mitochondrial complex III plays a pivotal role in the execution of ferroptosis induced by cysteine starvation.

T. Homma, J. Fujii, Hideyo Sato, 2021, Archives of biochemistry and biophysics.

Quantitative analysis of γ-glutamylpeptides by liquid chromatography-mass spectrometry and application for γ-glutamyltransferase assays.

Y. Ikeda, J. Fujii, Sho Kobayashi, 2019, Analytical biochemistry.

Growth retardation in human cervical dysplasia-derived cell lines by beta-carotene through down-regulation of epidermal growth factor receptor.

T. Noda, J. Fujii, H. Moriwaki, 1995, The American journal of clinical nutrition.

Apoptosis and expression of apoptosis-related genes in the mouse testis following heat exposure.

J. Fujii, T. Nakada, I. Sasagawa, 2002, Fertility and sterility.

Potential involvement of ubiquitin‐proteasome system dysfunction associated with oxidative stress in the pathogenesis of sickle cell disease

T. Homma, J. Fujii, M. Madkaikar, 2018, British journal of haematology.

Testis-specific peroxiredoxin 4 variant is not absolutely required for spermatogenesis and fertility in mice

T. Homma, T. Kurahashi, J. Fujii, 2020, Scientific Reports.

Structural Analysis of Amino Acids, Oxidized by Reactive Oxygen Species and an Antibody against N-Formylkynurenine

Y. Ikeda, J. Fujii, Y. Ohba, 2006 .

An abortive apoptotic pathway induced by singlet oxygen is due to the suppression of caspase activation.

Y. Ikeda, J. Fujii, H. Imai, 2005, The Biochemical journal.

Increased ophthalmic acid production is supported by amino acid catabolism under fasting conditions in mice.

Jaeyong Lee, J. Fujii, Sho Kobayashi, 2017, Biochemical and biophysical research communications.

Edaravone, a free radical scavenger, protects against ferroptotic cell death in vitro.

T. Homma, J. Fujii, Hideyo Sato, 2019, Experimental cell research.

Phorbol ester induces manganese-superoxide dismutase in tumor necrosis factor-resistant cells.

N. Taniguchi, J. Fujii, 1991, The Journal of biological chemistry.

Growth suppression and induction of heat-shock protein-70 by 9-cis beta-carotene in cervical dysplasia-derived cells.

J. Fujii, H. Moriwaki, Y. Muto, 1997, Life sciences.

Redox reactions in mammalian spermatogenesis and the potential targets of reactive oxygen species under oxidative stress

J. Fujii, H. Imai, 2014, Spermatogenesis.

Cooperative function of antioxidant and redox systems against oxidative stress in male reproductive tissues.

J. Fujii, Y. Iuchi, S. Matsuki, 2003, Asian journal of andrology.

Colocalization of polyol-metabolizing enzymes and immunological detection of fructated proteins in the female reproductive system of the rat

J. Fujii, Motoko Takahashi, T. Kaneko, 2003, Histochemistry and Cell Biology.

Localization and physiological implication of polyol-metabolyzing enzymes in male and female reproductive systems of rat

J. Fujii, Motoko Takahashi, T. Kaneko, 2002 .

DNA cleavage induced by glycation of Cu,Zn-superoxide dismutase.

H. Kaneto, N. Taniguchi, J. Fujii, 1994, The Biochemical journal.

Specific inactivation of cysteine protease-type cathepsin by singlet oxygen generated from naphthalene endoperoxides.

J. Fujii, F. Okada, Y. Ohba, 2005, Biochemical and biophysical research communications.

Peroxisome proliferator-activated receptor δ rescues xCT-deficient cells from ferroptosis by targeting peroxisomes.

J. Fujii, H. Seo, J. S. Hwang, 2021, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Ascorbate Is a Primary Antioxidant in Mammals

J. Fujii, T. Osaki, Tomoki Bo, 2022, Molecules.

Developmental retardation in neonates of aldehyde reductase (AKR1A)-deficient mice is associated with low ascorbic acid and high corticosterone levels.

H. Asao, T. Homma, J. Fujii, 2021, The Journal of nutritional biochemistry.

Cystathionine Is a Novel Substrate of Cystine/Glutamate Transporter

M. Sugimoto, T. Soga, M. Osaki, 2015, The Journal of Biological Chemistry.

A marked increase in free copper levels in the plasma and liver of LEC rats: an animal model for Wilson disease and liver cancer.

N. Taniguchi, J. Fujii, K. Suzuki, 1998, Free radical research.

Induction of ferroptosis by singlet oxygen generated from naphthalene endoperoxide.

T. Homma, J. Fujii, Sho Kobayashi, 2019, Biochemical and biophysical research communications.

Thiolprotease inhibitor, EST, can inhibit thrombin-induced platelet activation.

J. Fujii, H. Ishii, S. Hiraishi, 1990, Thrombosis research.

Double Knockout of Peroxiredoxin 4 (Prdx4) and Superoxide Dismutase 1 (Sod1) in Mice Results in Severe Liver Failure

T. Homma, Jaeyong Lee, T. Kurahashi, 2018, Oxidative medicine and cellular longevity.

Ablation of aldehyde reductase aggravates carbon tetrachloride-induced acute hepatic injury involving oxidative stress and endoplasmic reticulum stress.

T. Homma, Jaeyong Lee, J. Fujii, 2016, Biochemical and biophysical research communications.

Antithetical Roles of Reactive Oxygen Species in Mammalian Reproduction

J. Fujii, S. Tsunoda, N. Kimura, 2014 .

NO-DEPENDENT OXIDATION OF SELENO-CYSTEINE IN THE ACTIVE CENTER OF GLUTATHIONE PEROXIDASE IS RESPONSIBLE FOR ITS INACTIVATION

N. Taniguchi, J. Fujii, T. Takao, 1997 .

Apoptotic cell death triggered by nitric oxide in pancreatic beta-cells.

H. Kaneto, T. Matsuoka, Y. Yamasaki, 1995, Diabetes.

Kouji, Kazuo Suzuki, J. Fujii, 2006 .

Heterozygous SOD1 deficiency in mice with an NZW background causes male infertility and an aberrant immune phenotype

H. Asao, T. Homma, J. Fujii, 2019, Free radical research.

Application of Glutathione as Anti-Oxidative and Anti-Aging Drugs.

T. Homma, J. Fujii, 2015, Current drug metabolism.

B- to plasma-cell terminal differentiation entails oxidative stress and profound reshaping of the antioxidant responses.

J. Fujii, S. Rhee, S. Masciarelli, 2010, Antioxidants & redox signaling.

Characterization and localization to human chromosome 1 of human fast-twitch skeletal muscle calsequestrin gene

H. Willard, J. Fujii, D. Maclennan, 1990, Somatic cell and molecular genetics.

The protective role of glutathione peroxidase in apoptosis induced by reactive oxygen species.

Y. Matsuzawa, N. Taniguchi, J. Fujii, 1996, Journal of biochemistry.

Co‐expression of slow‐twitch/cardiac muscle Ca2+‐ATPase (SERCA2) and phospholamban

J. Fujii, K. Maruyama, D. Maclennan, 1990, FEBS letters.

The human ryanodine receptor gene: its mapping to 19q13.1, placement in a chromosome 19 linkage group, and exclusion as the gene causing myotonic dystrophy.

H. Willard, M. Phillips, B. Wieringa, 1990, American journal of human genetics.

Oxidative stress caused by glycation of Cu,Zn-superoxide dismutase and its effects on intracellular components.

H. Kaneto, N. Taniguchi, J. Fujii, 1996, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Manganese-superoxide dismutase in endothelial cells: localization and mechanism of induction.

Keiichiro Suzuki, N. Taniguchi, J. Fujii, 1993, The American journal of physiology.

Redox regulation of fertilisation and the spermatogenic process.

J. Fujii, S. Tsunoda, 2011, Asian journal of andrology.

Ascorbic acid insufficiency impairs spatial memory formation in juvenile AKR1A(cid:2)knockout mice

M. Nakane, T. Homma, J. Fujii, 2019 .

Enhanced expression of cystine/glutamate transporter in the lung caused by the oxidative-stress-inducing agent paraquat.

M. Osaki, J. Fujii, Hideyo Sato, 2012, Free radical biology & medicine.

Identification of a mutation in porcine ryanodine receptor associated with malignant hyperthermia.

K. Otsu, J. Fujii, P. O'Brien, 1991, Science.

Ryanodine receptor gene is a candidate for predisposition to malignant hyperthermia

M. Phillips, B. Britt, J. Fujii, 1990, Nature.

Polymorphisms and deduced amino acid substitutions in the coding sequence of the ryanodine receptor (RYR1) gene in individuals with malignant hyperthermia.

B. Britt, K. Otsu, J. Fujii, 1992, Genomics.

The Oxidation of Selenocysteine Is Involved in the Inactivation of Glutathione Peroxidase by Nitric Oxide Donor*

M. Hori, N. Taniguchi, J. Fujii, 1997, The Journal of Biological Chemistry.

Molecular cloning of cDNA encoding human and rabbit forms of the Ca2+ release channel (ryanodine receptor) of skeletal muscle sarcoplasmic reticulum.

M. Phillips, N. Green, K. Otsu, 1990, The Journal of biological chemistry.

Molecular Structure of Canine Cardiac Phospholamban, the Regulatory Protein of Ca Pump ATPase of Sarcoplasmic Reticulum

J. Fujii, M. Tada, M. Kadoma, 1989 .

Molecular structure and function of phospholamban: the regulatory protein of calcium pump in cardiac sarcoplasmic reticulum.

J. Fujii, M. Tada, Y. Kimura, 1989, Advances in experimental medicine and biology.

Protein Phosphorylation in Cardiac Sarcoplasmic Reticulum and Its Functional Consequences

J. Fujii, M. Tada, M. Kadoma, 1986 .

Chromosome mapping of five human cardiac and skeletal muscle sarcoplasmic reticulum protein genes.

D. Ward, K. Otsu, J. Fujii, 1993, Genomics.

The expression of glutathione reductase in the male reproductive system of rats supports the enzymatic basis of glutathione function in spermatogenesis.

J. Fujii, H. Kurachi, T. Fujii, 2002, European journal of biochemistry.

Caspase and Bid Involvement in Clostridium difficile Toxin A-Induced Apoptosis and Modulation of Toxin A Effects by Glutamine and Alanyl-Glutamine In Vivo and In Vitro

R. Guerrant, J. Fujii, B. Carneiro, 2006, Infection and Immunity.

Increased protein glycation in cerebrospinal fluid of Alzheimer’s disease 2 2 Abbreviations: AD, Alzheimer’s disease; AGEs, advanced glycation end products; apo, apolipoprotein; BSA, bovine serum albumin; CSF, cerebrospinal fluid; ELISA, enzyme-linked immunosorbent assay; PBS, phosphate buffe

G. Siest, N. Taniguchi, J. Fujii, 2001, Neurobiology of Aging.

Nitric oxide produced by NOS2 copes with the cytotoxic effects of superoxide in macrophages

T. Homma, J. Fujii, Sho Kobayashi, 2021, Biochemistry and biophysics reports.

Involvement of Ser-451 and Ser-452 in the Catalysis of Human γ-Glutamyl Transpeptidase (*)

Y. Ikeda, J. Fujii, A. Meister, 1995, The Journal of Biological Chemistry.

Human γ-Glutamyl Transpeptidase Mutants Involving Conserved Aspartate Residues and the Unique Cysteine Residue of the Light Subunit (*)

Y. Ikeda, J. Fujii, A. Meister, 1995, The Journal of Biological Chemistry.

Localization and physiological implication of aldose reductase and sorbitol dehydrogenase in reproductive tracts and spermatozoa of male rats.

J. Fujii, Motoko Takahashi, T. Nakada, 2002, Journal of andrology.

Critical Role of the Sulfiredoxin-Peroxiredoxin IV Axis in Urethane-Induced Non-Small Cell Lung Cancer

Yi Hao, J. Fujii, Pratik Thapa, 2023, Antioxidants.

Part IV • Chapter 11 – Superoxide dismutases in exercise and disease

T. Kizaki, Keiichiro Suzuki, N. Taniguchi, 2000 .

Prevention of tumor progression as the ultimate goal of cancer therapy

J. Fujii, F. Okada, 2005 .

Functional consequences of alterations to amino acids located in the catalytic center (isoleucine 348 to threonine 357) and nucleotide-binding domain of the Ca2+-ATPase of sarcoplasmic reticulum.

J. Fujii, D. Clarke, T. W. Loo, 1989, The Journal of biological chemistry.

Induction of Aldose Reductase Gene Expression in LEC Rats during the Development of the Hereditary Hepatitis and Hepatoma

Keiichiro Suzuki, K. Aozasa, N. Taniguchi, 1996, Japanese journal of cancer research : Gann.

TheHumanRyanodine Receptor Gene:ItsMapping to19ql3.1, Placement ina Chromosome19Linkage Group,andExclusion as theGeneCausing Myotonic Dystrophy

M. Phillips, J. Fujii, F. Zorzato, 1990 .

In Vivo Study on Cross Talk between Inducible Nitric-Oxide Synthase and Cyclooxygenase in Rat Gastric Mucosa: Effect of Cyclooxygenase Activity on Nitric Oxide Production

T. Shimosegawa, J. Fujii, T. Yoshimura, 2004, Journal of Pharmacology and Experimental Therapeutics.

Rapid Apoptosis Induced by Shiga Toxin in HeLa Cells

T. Yutsudo, J. Fujii, T. Matsui, 2003, Infection and Immunity.

Inactivation of Glutathione Peroxidase by Nitric Oxide

S. Fujii, Keiichiro Suzuki, N. Taniguchi, 1995, The Journal of Biological Chemistry.

Peroxiredoxin 4 knockout results in elevated spermatogenic cell death via oxidative stress.

M. Ikawa, M. Okabe, Y. Ikeda, 2009, The Biochemical journal.

Implication of oxidative stress as a cause of autoimmune hemolytic anemia in NZB mice.

Takeshi Mikami, J. Fujii, T. Mikami, 2010, Free radical biology & medicine.

SOD1 deficiency decreases proteasomal function, leading to the accumulation of ubiquitinated proteins in erythrocytes.

T. Homma, Jaeyong Lee, T. Kurahashi, 2015, Archives of biochemistry and biophysics.

Purification of Mn-SOD and its monoclonal antibody Mn-SOD has been purified and crystallized from human livers. The enzyme

Keiichiro Suzuki, J. Fujii, T. Nakata, 2006 .

Expression of Mn-superoxide dismutase in carcinogenesis.

N. Taniguchi, J. Fujii, K. Suzuki, 1992, The Tohoku journal of experimental medicine.

A substitution of cysteine for arginine 614 in the ryanodine receptor is potentially causative of human malignant hyperthermia.

B. Britt, K. Otsu, J. Fujii, 1991, Genomics.

The structural organization of the human skeletal muscle ryanodine receptor (RYR1) gene.

M. Phillips, P. D. de Jong, P. Jong, 1996, Genomics.

Unveiling the roles of the glutathione redox system in vivo by analyzing genetically modified mice

Junitsu Ito, T. Kurahashi, J. Fujii, 2011, Journal of clinical biochemistry and nutrition.

LAT1 inhibitor JPH203 sensitizes cancer cells to radiation by enhancing radiation-induced cellular senescence

O. Inanami, O. Nakajima, J. Fujii, 2021, Translational oncology.

Intrinsic oxidative stress causes either 2-cell arrest or cell death depending on developmental stage of the embryos from SOD1-deficient mice.

J. Fujii, Y. Iuchi, S. Tsunoda, 2010, Molecular human reproduction.

Nrf2-regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress.

S. Biswal, C. Harvey, J. Fujii, 2009, Free radical biology & medicine.

Involvement of Nitric Oxide in Protecting against Radical Species and Autoregulation of M1-Polarized Macrophages through Metabolic Remodeling

J. Fujii, T. Osaki, 2023, Molecules.

Superoxide Radicals in the Execution of Cell Death

T. Homma, J. Fujii, T. Osaki, 2022, Antioxidants.

Nitric oxide protects against ferroptosis by aborting the lipid peroxidation chain reaction.

T. Homma, J. Fujii, M. Conrad, 2021, Nitric oxide : biology and chemistry.

Cystine/glutamate transporter, system xc-, is involved in nitric oxide production in mouse peritoneal macrophages.

T. Homma, J. Fujii, Hideyo Sato, 2018, Nitric oxide : biology and chemistry.

Induction of manganese superoxide dismutase mRNA by okadaic acid and protein synthesis inhibitors.

Y. Ikeda, N. Taniguchi, J. Fujii, 1994, The Biochemical journal.

Alanyl-glutamine hastens morphologic recovery from 5-fluorouracil-induced mucositis in mice.

R. Guerrant, J. Fujii, T. Obrig, 2004, Nutrition.

Peroxiredoxin IV is a secretable protein with heparin-binding properties under reduced conditions.

N Taniguchi, N. Taniguchi, J. Fujii, 2000, Journal of biochemistry.

The Association of Peroxiredoxin 4 with the Initiation and Progression of Hepatocellular Carcinoma.

H. Uramoto, T. Homma, J. Fujii, 2019, Antioxidants & redox signaling.

Oxidative Stress-Induced Carcinogenesis and Its Prevention Guest Editor: Shinya Toyokuni Molecular Mechanisms of Inflammation-Induced Carcinogenesis

J. Fujii, F. Okada, 2006 .

Oxidative Stress-Induced Carcinogenesis and Its Prevention

J. Fujii, F. Okada, 2006 .

Identification of a Lipid Peroxidation Product as the Source of Oxidation-specific Epitopes Recognized by Anti-DNA Autoantibodies*

Y. Takasaki, J. Fujii, K. Uchida, 2010, The Journal of Biological Chemistry.

Pleiotropic Actions of Aldehyde Reductase (AKR1A)

T. Homma, J. Fujii, Motoko Takahashi, 2021, Metabolites.

Prdx4 is a compartment-specific H2O2 sensor that regulates neurogenesis by controlling surface expression of GDE2

J. Fujii, S. Sockanathan, Shanthini Sockanathan, 2015, Nature Communications.

Endoplasmic Reticulum Thiol Oxidase Deficiency Leads to Ascorbic Acid Depletion and Noncanonical Scurvy in Mice

G. Yeo, D. Ron, J. Fujii, 2012, Molecular cell.

Different expression patterns of nitric oxide synthase isozymes in various gynecological cancers

Y. Matsuzawa, M. Koizumi, N. Taniguchi, 1999, Journal of Cancer Research and Clinical Oncology.

Detection of the HAL Gene in Swine: A Point Mutation in the Skeletal Muscle Ryanodine Receptor Gene (RYR1)

J. Fujii, 1993 .

Roles of N-terminal active cysteines and C-terminal cysteine-selenocysteine in the catalytic mechanism of mammalian thioredoxin reductase.

N. Taniguchi, J. Fujii, T. Fujii, 2001, Journal of Biochemistry (Tokyo).

Oxidative stress and redox regulation of gametogenesis, fertilization, and embryonic development

J. Fujii, S. Tsunoda, N. Kimura, 2014, Reproductive medicine and biology.

Emerging connections between oxidative stress, defective proteolysis, and metabolic diseases

T. Homma, J. Fujii, 2020, Free radical research.

Functional expression of rat thioredoxin reductase: selenocysteine insertion sequence element is essential for the active enzyme.

N. Taniguchi, J. Fujii, T. Fujii, 1999, The Biochemical journal.

Active glycation in neurofibrillary pathology of Alzheimer disease: Nε-(Carboxymethyl) lysine and hexitol-lysine

R. Castellani, Mark A. Smith, M. Vitek, 2001 .

Sarcoplasmic reticulum Ca-ATPase: distinction of phosphoenzymes formed from MgATP and CaATP as substrates and interconversion of the phosphoenzymes by Mg2+ and Ca2+.

J. Fujii, H. Katayama, S. Yamada, 1986, Journal of biochemistry.

Induction of nitric oxide synthase and concomitant suppression of superoxide dismutases in experimental colitis in rats.

N. Taniguchi, J. Fujii, H. Seo, 1995, Archives of biochemistry and biophysics.

Effect of cAMP on inducible nitric oxide synthase gene expression: its dual and cell-specific functions.

N. Taniguchi, J. Fujii, A. Okado-Matsumoto, 2000, Antioxidants & redox signaling.

Roles of purine nucleotides and adenosine in enhancing NOS II gene expression in interleukin-1 beta-stimulated rat vascular smooth muscle cells.

N. Taniguchi, J. Fujii, H. Seo, 1997, Free radical research.

The effect of nitric oxide synthase inhibitor on form-deprivation myopia.

Y. Tano, T. Fujikado, N. Taniguchi, 1997, Current eye research.

Loss of Peroxiredoxin IV Protects Mice from Azoxymethane/Dextran Sulfate Sodium-Induced Colorectal Cancer Development

Yi Hao, J. Fujii, Eun Y. Lee, 2023, Antioxidants.

Kidney fibrosis is independent of the amount of ascorbic acid in mice with unilateral ureteral obstruction

Y. Tomita, N. Otsuki, T. Kurahashi, 2014, Free radical research.

Glycation of apolipoprotein E impairs its binding to heparin: identification of the major glycation site.

G. Siest, N. Taniguchi, J. Fujii, 1999, Biochimica et biophysica acta.

Expression of TRPM8 in human reactive lymphoid tissues and mature B-cell neoplasms

J. Fujii, K. Ishizawa, M. Yamakawa, 2018, Oncology letters.

Carbonyl stress and detoxification ability in the male genital tract and testis of rats

Y. Ikeda, J. Fujii, K. Uchida, 2004, Histochemistry and Cell Biology.

Decreased reproductive performance in xCT-knockout male mice

T. Homma, T. Kurahashi, J. Fujii, 2017, Free radical research.

Consequences of a peroxiredoxin 4 (Prdx4) deficiency on learning and memory in mice.

T. Homma, J. Fujii, T. Osaki, 2022, Biochemical and biophysical research communications.

Ascorbic acid insufficiency impairs spatial memory formation in juvenile AKR1A-knockout mice

T. Homma, J. Fujii, M. Shichiri, 2019, Journal of clinical biochemistry and nutrition.

Reductive detoxification of acrolein as a potential role for aldehyde reductase (AKR1A) in mammals.

T. Homma, Jaeyong Lee, T. Kurahashi, 2014, Biochemical and biophysical research communications.

Growth Retardation in Human Cervical Dysplasia-Derived Cell Lines by β-Carotene

T. Noda, J. Fujii, H. Moriwaki, 1997 .

Heightened aggressive behavior in mice deficient in aldo-keto reductase 1a (Akr1a)

T. Homma, S. Okano, O. Nakajima, 2017, Behavioural Brain Research.

Ascorbic acid reverses the prolonged anesthetic action of pentobarbital in Akr1a-knockout mice.

Junitsu Ito, N. Otsuki, T. Kurahashi, 2014, Life sciences.

Effect of a nitric oxide synthase inhibitor, S-ethylisothiourea, on cultured cells and cardiovascular functions of normal and lipopolysaccharide-treated rabbits.

H. Kaneto, N. Taniguchi, J. Fujii, 1996, Journal of biochemistry.

Oxidative Stress and Dysfunction of the Intracellular Proteolytic Machinery

T. Homma, J. Fujii, 2019, Dietary Interventions in Liver Disease.

Critical Roles of the Cysteine–Glutathione Axis in the Production of γ-Glutamyl Peptides in the Nervous System

J. Fujii, T. Osaki, Y. Matsuda, 2023, International journal of molecular sciences.

Activation of Human Platelet Phospholipase C by Calpain-I

J. Fujii, H. Ishii, M. Kuboki, 1991 .

γ-Glutamylcysteine synthetase and γ-glutamyl transferase as differential enzymatic sources of γ-glutamylpeptides in mice

Y. Ikeda, J. Fujii, Sho Kobayashi, 2020, Amino Acids.

Characterization of structural unit of phospholamban by amino acid sequencing and electrophoretic analysis.

J. Fujii, F. Sakiyama, M. Tada, 1986, Biochemical and biophysical research communications.

Structure of the rabbit phospholamban gene, cloning of the human cDNA, and assignment of the gene to human chromosome 6.

H. Willard, J. Fujii, Á. Zarain-Herzberg, 1991, The Journal of biological chemistry.

Regulation of Ca2+-pump from cardiac sarcoplasmic reticulum.

J. Fujii, M. Inui, M. Tada, 1988, Methods in Enzymology.

Expression and mutation of Ca2+ ATPases of the sarcoplasmic reticulum.

J. Fujii, D. Clarke, D. Maclennan, 1989, Cell motility and the cytoskeleton.

Expression of DNA methyltransferase in LEC rats during hepatocarcinogenesis.

N. Hayashi, H. Fusamoto, T. Kamada, 1993, Carcinogenesis.

Defective biosynthesis of ascorbic acid in Sod1-deficient mice results in lethal damage to lung tissue.

H. Asao, S. Toyokuni, T. Homma, 2020, Free radical biology & medicine.

Biological Action of Singlet Molecular Oxygen from the Standpoint of Cell Signaling, Injury and Death

J. Fujii, Y. Matsuda, Yuya Soma, 2023, Molecules.

Identity of a major 3-deoxyglucosone-reducing enzyme with aldehyde reductase in rat liver established by amino acid sequencing and cDNA expression.

M. Takahashi, N. Taniguchi, J. Fujii, 1993, Gene.

A malfunction in triglyceride transfer from the intracellular lipid pool to apoB in enterocytes of SOD1‐deficient mice

Junitsu Ito, N. Otsuki, T. Kurahashi, 2012, FEBS letters.

Characteristics of Skeletal Muscle Fibers of SOD1 Knockout Mice

H. Miyata, J. Fujii, H. Nagahisa, 2015, Oxidative medicine and cellular longevity.

Oxidative Stress Caused by an SOD1 Deficiency Triggers the Accumulation of Oxidatively Modified Carbonic Anhydrase II in Erythrocytes

T. Homma, J. Fujii, 2018 .

Copper chelation by d-penicillamine alleviates melanocyte death induced by rhododendrol without inhibiting tyrosinase.

T. Homma, J. Fujii, Tamio Suzuki, 2023, Biochemical and biophysical research communications.

Nitric oxide synthase from rat colorectum: purification, peptide sequencing, partial PCR cloning, and immunohistochemistry.

N. Taniguchi, J. Fujii, H. Seo, 1994, Journal of biochemistry.

Possible involvement of the membrane-bound form of peroxiredoxin 4 in acrosome formation during spermiogenesis of rats.

J. Fujii, T. Nakada, I. Sasagawa, 2001, European journal of biochemistry.

Impaired expression of peroxiredoxin 4 in damaged testes by artificial cryptorchidism

J. Fujii, I. Sasagawa, Y. Iuchi, 2002, Redox report : communications in free radical research.

Measurement of peroxiredoxin-4 serum levels in rat tissue and its use as a potential marker for hepatic disease.

Y. Ikeda, J. Fujii, Motoko Takahashi, 2012, Molecular medicine reports.

Defense systems to avoid ferroptosis caused by lipid peroxidation-mediated membrane damage

J. Fujii, Ken‐ichi Yamada, 2023, Free radical research.

Transient elevation of glutathione peroxidase 1 around the time of eyelid opening in the neonatal rat.

H. Yamashita, Y. Ikeda, J. Fujii, 2003, Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.

Fundamental roles of reactive oxygen species and protective mechanisms in the female reproductive system

J. Fujii, F. Okada, Y. Iuchi, 2005 .

B- to plasma-cell terminal differentiation entails oxidative stress and profound reshaping of the antioxidant responses.

J. Fujii, S. Rhee, R. Sitia, 2010, Antioxidants & redox signaling.

Heme requirement for production of active endothelial nitric oxide synthase in baculovirus-infected insect cells.

N. Niikawa, N. Taniguchi, J. Fujii, 1995, Biochemical and biophysical research communications.

Measurement of peroxiredoxin-4 serum levels in rat tissue and its use as a potential marker for hepatic disease.

Y. Ikeda, J. Fujii, Motoko Takahashi, 2012, Molecular medicine reports.

Carnosine dipeptidase II (CNDP2) protects cells under cysteine insufficiency by hydrolyzing glutathione-related peptides.

T. Homma, J. Fujii, Hideyo Sato, 2021, Free radical biology & medicine.

Decreased reproductive performance in xCT-knockout male mice

T. Homma, J. Fujii, Hideyo Sato, 2017, Free radical research.

Expression of N-terminally truncated forms of rat peroxiredoxin-4 in insect cells.

Y. Ikeda, J. Fujii, H. Ihara, 2010, Protein Expression and Purification.

The Association of Peroxiredoxin 4 with the Initiation and Progression of Hepatocellular Carcinoma.

H. Uramoto, T. Homma, J. Fujii, 2019, Antioxidants & redox signaling.