M. Okada

发表

Cytoplasmic localization of DGK&zgr; exerts a protective effect against p53-mediated cytotoxicity

Mitsuyoshi Iino, Masashi Okada, Ken Tachibana, 2013, Journal of Cell Science.

Inhibition of the Lipid Droplet–Peroxisome Proliferator-Activated Receptor α Axis Suppresses Cancer Stem Cell Properties

M. Okada, C. Kitanaka, Kenta Kuramoto, 2021, Genes.

DGKζ under stress conditions: “to be nuclear or cytoplasmic, that is the question”.

Toshiaki Tanaka, M. Topham, A. Martelli, 2014, Advances in biological regulation.

Coordinated intracellular translocation of phosphoinositide-specific phospholipase C-delta with the cell cycle.

M. Okada, M. Fujii, H. Yagisawa, 2006, Biochimica et biophysica acta.

AS602801, an Anticancer Stem Cell Candidate Drug, Reduces Survivin Expression and Sensitizes A2780 Ovarian Cancer Stem Cells to Carboplatin and Paclitaxel

M. Okada, C. Kitanaka, S. Seino, 2018, AntiCancer Research.

Pivotal role for ROS activation of p38 MAPK in the control of differentiation and tumor-initiating capacity of glioma-initiating cells.

M. Okada, C. Kitanaka, T. Kayama, 2014, Stem cell research.

Akt phosphorylation and nuclear phosphoinositide association mediate mRNA export and cell proliferation activities by ALY

M. Okada, K. Ye, Sang-Wuk Jang, 2008, Proceedings of the National Academy of Sciences.

Involvement of GLUT1-mediated glucose transport and metabolism in gefitinib resistance of non-small-cell lung cancer cells

M. Okada, C. Kitanaka, S. Seino, 2018, Oncotarget.

Glioma Stem Cells : An Update: ―アップデート―

M. Okada, C. Kitanaka, 2018 .

Impact of H3K27 Demethylase Inhibitor GSKJ4 on NSCLC Cells Alone and in Combination with Metformin.

M. Okada, C. Kitanaka, H. Oizumi, 2016, Anticancer research.

JNK contributes to temozolomide resistance of stem-like glioblastoma cells via regulation of MGMT expression.

M. Okada, C. Kitanaka, T. Kayama, 2014, International journal of oncology.

Targeting the facilitative glucose transporter GLUT1 inhibits the self-renewal and tumor-initiating capacity of cancer stem cells

M. Okada, C. Kitanaka, S. Seino, 2014, Oncotarget.

A Small-molecule Kinase Inhibitor, CEP-1347, Inhibits Survivin Expression and Sensitizes Ovarian Cancer Stem Cells to Paclitaxel

H. Yamashita, M. Okada, C. Kitanaka, 2018, AntiCancer Research.

Requirement of JNK signaling for self-renewal and tumor-initiating capacity of ovarian cancer stem cells.

M. Okada, C. Kitanaka, T. Ohta, 2014, Anticancer research.

Phospholipase C isoforms are localized at the cleavage furrow during cytokinesis.

M. Okada, H. Yagisawa, Y. Naito, 2006, Journal of biochemistry.

Targeting Folate Metabolism Is Selectively Cytotoxic to Glioma Stem Cells and Effectively Cooperates with Differentiation Therapy to Eliminate Tumor-Initiating Cells in Glioma Xenografts

M. Okada, C. Kitanaka, Masahiro Yamamoto, 2021, International journal of molecular sciences.

Calcium fluxes cause nuclear shrinkage and the translocation of phospholipase C-δ1 into the nucleus

M. Okada, H. Yagisawa, S. Maekawa, 2010, Neuroscience Letters.

Inhibition of the Phospholipase Cε–c-Jun N-Terminal Kinase Axis Suppresses Glioma Stem Cell Properties

M. Okada, C. Kitanaka, Shuhei Suzuki, 2022, International journal of molecular sciences.

Licochalcone A specifically induces cell death in glioma stem cells via mitochondrial dysfunction

M. Okada, C. Kitanaka, T. Kayama, 2017, FEBS open bio.

Influence of membrane curvature on the structure of the membrane-associated pleckstrin homology domain of phospholipase C-delta1.

K. Nishimura, M. Okada, H. Yagisawa, 2009, Biochimica et biophysica acta.

DGKζ Downregulation Enhances Osteoclast Differentiation and Bone Resorption Activity Under Inflammatory Conditions

Toshiaki Tanaka, M. Topham, M. Okada, 2017, Journal of cellular physiology.

Ebp1 Sumoylation, Regulated by TLS/FUS E3 Ligase, Is Required for its Anti-proliferative Activity

M. Okada, Zhixue Liu, K. Ye, 2009, Oncogene.

Dexamethasone Sensitizes Cancer Stem Cells to Gemcitabine and 5-Fluorouracil by Increasing Reactive Oxygen Species Production through NRF2 Reduction

M. Okada, C. Kitanaka, T. Yoshioka, 2021, Life.

Rho-Associated Protein Kinase (ROCK) Inhibitors Inhibit Survivin Expression and Sensitize Pancreatic Cancer Stem Cells to Gemcitabine.

M. Okada, C. Kitanaka, S. Seino, 2016, Anticancer research.

The novel JNK inhibitor AS602801 inhibits cancer stem cells in vitro and in vivo

M. Okada, C. Kitanaka, S. Seino, 2016, Oncotarget.

Human BRE1 is an E3 ubiquitin ligase for Ebp1 tumor suppressor.

D. Brat, W. Gu, Shi-Yong Sun, 2008, Molecular biology of the cell.

Human BRE 1 Is an E 3 Ubiquitin Ligase for Ebp 1 Tumor Suppressor

D. Brat, W. Gu, Shi-Yong Sun, 2022 .

Single-Molecule Visualization of Diffusion at the Solution−Crystal Interface

Tomonobu M. Watanabe, H. Higuchi, K. Tsukamoto, 2008 .

Ebp1 Association with Nucleophosmin/B23 Is Essential for Regulating Cell Proliferation and Suppressing Apoptosis*

M. Okada, K. Ye, Sung-Wuk Jang, 2007, Journal of Biological Chemistry.

Akt phosphorylation of merlin enhances its binding to phosphatidylinositols and inhibits the tumor-suppressive activities of merlin.

M. Okada, K. Ye, L. Neri, 2009, Cancer research.

Phospholipase Cδ1 associates with importin β1 and translocates into the nucleus in a Ca2+‐dependent manner

M. Okada, H. Hirata, H. Yagisawa, 2005 .

DGKζ is degraded through the cytoplasmic ubiquitin-proteasome system under excitotoxic conditions, which causes neuronal apoptosis because of aberrant cell cycle reentry.

Toshiaki Tanaka, M. Topham, A. Martelli, 2012, Cellular signalling.

Antitumor activity of gemcitabine against high-grade meningioma in vitro and in vivo.

M. Okada, C. Kitanaka, K. Arita, 2017, Oncotarget.

Verteporfin inhibits oxidative phosphorylation and induces cell death specifically in glioma stem cells

M. Okada, C. Kitanaka, S. Seino, 2019, The FEBS journal.

NMDA receptor-mediated Ca2+ influx triggers nucleocytoplasmic translocation of diacylglycerol kinase ζ under oxygen–glucose deprivation conditions, an in vitro model of ischemia, in rat hippocampal slices

Toshiaki Tanaka, M. Okada, Y. Hozumi, 2012, Histochemistry and Cell Biology.

Gambogic amide, a selective agonist for TrkA receptor that possesses robust neurotrophic activity, prevents neuronal cell death

D. Stein, M. Okada, K. Ye, 2007, Proceedings of the National Academy of Sciences.

Role of the N-terminal hydrophobic residues of DGKε in targeting the endoplasmic reticulum.

Toshiaki Tanaka, M. Topham, M. Okada, 2014, Biochimica et biophysica acta.

Glioma‐Initiating Cell Elimination by Metformin Activation of FOXO3 via AMPK

M. Okada, C. Kitanaka, J. Sunayama, 2012, Stem cells translational medicine.

Downregulation of diacylglycerol kinase ζ enhances activation of cytokine-induced NF-κB signaling pathway.

Toshiaki Tanaka, M. Topham, M. Okada, 2015, Biochimica et biophysica acta.

Resveratrol promotes proteasome-dependent degradation of Nanog via p53 activation and induces differentiation of glioma stem cells.

M. Okada, C. Kitanaka, Kaori Suzuki, 2013, Stem cell research.

Specific role of JNK in the maintenance of the tumor-initiating capacity of A549 human non-small cell lung cancer cells.

M. Okada, C. Kitanaka, Eriko Watanabe, 2013, Oncology reports.

JNK Signaling in the Control of the Tumor-Initiating Capacity Associated with Cancer Stem Cells.

M. Okada, C. Kitanaka, A. Sato, 2013, Genes & cancer.

Brexpiprazole, a Serotonin-Dopamine Activity Modulator, Can Sensitize Glioma Stem Cells to Osimertinib, a Third-Generation EGFR-TKI, via Survivin Reduction

M. Okada, C. Kitanaka, S. Seino, 2019, Cancers.

Brexpiprazole Reduces Survivin and Reverses EGFR Tyrosine Kinase Inhibitor Resistance in Lung and Pancreatic Cancer

M. Okada, C. Kitanaka, S. Seino, 2019, AntiCancer Research.

Targeting the K-Ras - JNK axis eliminates cancer stem-like cells and prevents pancreatic tumor formation

M. Okada, C. Kitanaka, S. Seino, 2014, Oncotarget.

Targeting JNK for therapeutic depletion of stem-like glioblastoma cells

M. Okada, C. Kitanaka, Kaori Suzuki, 2012, Scientific Reports.

Spironolactone, a Classic Potassium-Sparing Diuretic, Reduces Survivin Expression and Chemosensitizes Cancer Cells to Non-DNA-Damaging Anticancer Drugs

M. Okada, C. Kitanaka, S. Seino, 2019, Cancers.

In Situ Observation of Dislocations in Protein Crystals during Growth by Advanced Optical Microscopy

K. Tsukamoto, M. Okada, K. Nakajima, 2005 .

Roles for hENT1 and dCK in gemcitabine sensitivity and malignancy of meningioma

M. Okada, C. Kitanaka, Y. Sonoda, 2021, Neuro-oncology.

Olanzapine, an Atypical Antipsychotic, Inhibits Survivin Expression and Sensitizes Cancer Cells to Chemotherapeutic Agents.

M. Okada, C. Kitanaka, S. Seino, 2017, Anticancer research.

JNK suppression of chemotherapeutic agents-induced ROS confers chemoresistance on pancreatic cancer stem cells

M. Okada, C. Kitanaka, S. Seino, 2014, Oncotarget.

Therapeutic targeting of pancreatic cancer stem cells by dexamethasone modulation of the MKP-1–JNK axis

M. Okada, C. Kitanaka, S. Seino, 2020, The Journal of Biological Chemistry.

Nuclear phosphoinositide signaling regulates messenger RNA export

M. Okada, K. Ye, 2009, RNA biology.

Gemcitabine radiosensitization primes irradiated malignant meningioma cells for senolytic elimination by navitoclax

M. Okada, C. Kitanaka, S. Seino, 2021, Neuro-oncology advances.

Interaction of nucleosome assembly proteins abolishes nuclear localization of DGKζ by attenuating its association with importins.

Toshiaki Tanaka, M. Okada, Y. Hozumi, 2011, Experimental cell research.

AS602801 Sensitizes Ovarian Cancer Stem Cells to Paclitaxel by Down-regulating MDR1

M. Okada, C. Kitanaka, S. Seino, 2019, AntiCancer Research.

Gemcitabine Cooperates with Everolimus to Inhibit the Growth of and Sensitize Malignant Meningioma Cells to Apoptosis Induced by Navitoclax, an Inhibitor of Anti-Apoptotic BCL-2 Family Proteins

M. Okada, C. Kitanaka, Masahiro Yamamoto, 2022, Cancers.

Givinostat Inhibition of Sp1-dependent MGMT Expression Sensitizes Glioma Stem Cells to Temozolomide

M. Okada, C. Kitanaka, Shuhei Suzuki, 2023, AntiCancer Research.

Time-staggered inhibition of JNK effectively sensitizes chemoresistant ovarian cancer cells to cisplatin and paclitaxel.

M. Okada, C. Kitanaka, T. Ohta, 2016, Oncology reports.

Aripiprazole, an Antipsychotic and Partial Dopamine Agonist, Inhibits Cancer Stem Cells and Reverses Chemoresistance.

M. Okada, C. Kitanaka, S. Seino, 2016, Anticancer research.

Carboxyl‐terminal basic amino acids in the X domain are essential for the nuclear import of phospholipase C δ1

H. Sugimoto, M. Okada, M. Fujii, 2002, Genes to cells : devoted to molecular & cellular mechanisms.

Regulation of the intracellular localization of phosphoinositide-specific phospholipase cδ1

M. Okada, M. Fujii, H. Yagisawa, 2002 .

Diacylglycerol kinase ζ is associated with chromatin, but dissociates from condensed chromatin during mitotic phase in NIH3T3 cells

Masahiko Watanabe, A. Martelli, M. Okada, 2008, Journal of cellular biochemistry.

Reciprocal regulation of p53 and NF-κB by diacylglycerol kinase ζ.

Toshiaki Tanaka, M. Okada, Y. Hozumi, 2016, Advances in biological regulation.

DGKζ is involved in LPS-activated phagocytosis through IQGAP1/Rac1 pathway.

K. Kaibuchi, M. Topham, M. Okada, 2012, Biochemical and biophysical research communications.

Structure and Dynamics of the Phospholipase C-δ1 Pleckstrin Homology Domain Located at the Lipid Bilayer Surface*

M. Okada, H. Yagisawa, S. Tuzi, 2003, Journal of Biological Chemistry.

Netrin-1 mediates neuronal survival through PIKE-L interaction with the dependence receptor UNC5B

P. Mehlen, M. Okada, K. Ye, 2008, Nature Cell Biology.

Phosphatidylserine induces functional and structural alterations of the membrane‐associated pleckstrin homology domain of phospholipase C‐δ1

M. Okada, H. Yagisawa, S. Tuzi, 2007, The FEBS journal.

GSKJ4, A Selective Jumonji H3K27 Demethylase Inhibitor, Effectively Targets Ovarian Cancer Stem Cells.

M. Okada, C. Kitanaka, T. Ohta, 2015, Anticancer research.

Repositioning CEP-1347, a chemical agent originally developed for the treatment of Parkinson’s disease, as an anti-cancer stem cell drug

M. Okada, C. Kitanaka, S. Seino, 2017, Oncotarget.

Differential contribution of ROS to resveratrol-induced cell death and loss of self-renewal capacity of ovarian cancer stem cells.

M. Okada, C. Kitanaka, T. Ohta, 2015, Anticancer research.

AS602801, an Anti-Cancer Stem Cell Drug Candidate, Suppresses Gap-junction Communication Between Lung Cancer Stem Cells and Astrocytes

M. Okada, C. Kitanaka, S. Seino, 2018, AntiCancer Research.

In vitro and in vivo anti-tumor effects of brexpiprazole, a newly-developed serotonin-dopamine activity modulator with an improved safety profile

M. Okada, C. Kitanaka, S. Seino, 2019, Oncotarget.

Inhibition of Retinoblastoma Cell Growth by CEP1347 Through Activation of the P53 Pathway

H. Yamashita, M. Okada, C. Kitanaka, 2020, AntiCancer Research.

The Novel MDM4 Inhibitor CEP-1347 Activates the p53 Pathway and Blocks Malignant Meningioma Growth In Vitro and In Vivo

M. Okada, C. Kitanaka, Y. Sonoda, 2023, Biomedicines.

CEP-1347 Targets MDM4 Protein Expression to Activate p53 and Inhibit the Growth of Glioma Cells

M. Okada, C. Kitanaka, Y. Sonoda, 2022, AntiCancer Research.

Cellular expression and localization of DGKζ-interacting NAP1-like proteins in the brain and functional implications under hypoxic stress

Toshiaki Tanaka, M. Okada, Y. Hozumi, 2014, Histochemistry and Cell Biology.

Phospholipase Cdelta1 associates with importin beta1 and translocates into the nucleus in a Ca2+-dependent manner.

M. Okada, H. Hirata, H. Yagisawa, 2005, FEBS letters.

Doxazosin, a Classic Alpha 1-Adrenoceptor Antagonist, Overcomes Osimertinib Resistance in Cancer Cells via the Upregulation of Autophagy as Drug Repurposing

M. Okada, C. Kitanaka, S. Seino, 2020, Biomedicines.

Lurasidone Sensitizes Cancer Cells to Osimertinib by Inducing Autophagy and Reduction of Survivin

M. Okada, C. Kitanaka, S. Seino, 2021, AntiCancer Research.

Antagonizing MDM2 Overexpression Induced by MDM4 Inhibitor CEP-1347 Effectively Reactivates Wild-Type p53 in Malignant Brain Tumor Cells

M. Okada, C. Kitanaka, Y. Sonoda, 2023, Cancers.

Domatinostat Targets the FOXM1–Survivin Axis to Reduce the Viability of Ovarian Cancer Cells Alone and in Combination with Chemotherapeutic Agents

M. Okada, C. Kitanaka, Shuhei Suzuki, 2023, International journal of molecular sciences.

Antitumor activity of gemcitabine against high-grade meningioma in vitro and in vivo

M. Okada, C. Kitanaka, K. Arita, 2017, Oncotarget.

Cytoplasmic localization of DGK&zgr; exerts a protective effect against p53-mediated cytotoxicity

Toshiaki Tanaka, M. Topham, A. Martelli, 2013, Journal of Cell Science.

CEP-1347 Dually Targets MDM4 and PKC to Activate p53 and Inhibit the Growth of Uveal Melanoma Cells

M. Okada, C. Kitanaka, Keita Togashi, 2023, Cancers.