S. Moniot

发表

Structures, Substrates, and Regulators of Mammalian Sirtuins – Opportunities and Challenges for Drug Development

M. Weyand, S. Moniot, C. Steegborn, 2012, Front. Pharmacol..

Trapping of the Thioacylglyceraldehyde-3-phosphate Dehydrogenase Intermediate from Bacillus stearothermophilus

G. Bricogne, A. Mozzarelli, C. Vonrhein, 2008, Journal of Biological Chemistry.

Thienopyrimidinone Based Sirtuin-2 (SIRT2)-Selective Inhibitors Bind in the Ligand Induced Selectivity Pocket

M. Sternberg, E. Lam, S. Moniot, 2017, Journal of medicinal chemistry.

The Discovery of a Highly Selective 5,6,7,8‐Tetrahydrobenzo[4,5]thieno[2,3‐d]pyrimidin‐4(3H)‐one SIRT2 Inhibitor that is Neuroprotective in an in vitro Parkinson’s Disease Model

Ian F. Harrison, M. Sternberg, E. Lam, 2015, ChemMedChem.

The Sirtuin-2 Inhibitor AK7 Is Neuroprotective in Models of Parkinson’s Disease but Not Amyotrophic Lateral Sclerosis and Cerebral Ischemia

C. Ayata, S. Moniot, C. Steegborn, 2015, PloS one.

Development of 1,2,4-Oxadiazoles as Potent and Selective Inhibitors of the Human Deacetylase Sirtuin 2: Structure-Activity Relationship, X-ray Crystal Structure, and Anticancer Activity.

L. Altucci, A. Mai, A. Nebbioso, 2017, Journal of medicinal chemistry.

A blue light receptor that mediates RNA binding and translational regulation

S. Moniot, C. Steegborn, R. Bittl, 2019, Nature Chemical Biology.

Effects of 3‐Bromo‐4,5‐dihydroisoxazole Derivatives on Nrf2 Activation and Heme Oxygenase‐1 Expression

S. Moniot, C. Steegborn, A. Pinto, 2018, ChemistryOpen.

SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models

R. Abagyan, J. Marsh, J. Landers, 2016 .

SIRT 2-and NRF 2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington ’ s Disease Models Highlights

R. Abagyan, J. Marsh, J. Landers, 2016 .

Crystallization, diffraction data collection and preliminary crystallographic analysis of DING protein from Pseudomonas fluorescens.

M. Elias, E. Chabrière, S. Moniot, 2007, Acta crystallographica. Section F, Structural biology and crystallization communications.

Elucidation of the phosphate binding mode of DING proteins revealed by subangstrom X-ray crystallography.

Claude Lecomte, Dorothee Liebschner, Christian Jelsch, 2009, Journal of the American Chemical Society.

Structural basis for natural lactonase and promiscuous phosphotriesterase activities.

Giuseppe Manco, Claude Lecomte, Luigi Mandrich, 2008, Journal of molecular biology.

1,4-Dihydropyridines Active on the SIRT1/AMPK Pathway Ameliorate Skin Repair and Mitochondrial Function and Exhibit Inhibition of Proliferation in Cancer Cells.

D. Trisciuoglio, L. Altucci, A. Mai, 2016, Journal of medicinal chemistry.

Structure–function relationships in a bacterial DING protein

M. Elias, E. Chabrière, S. Moniot, 2007, FEBS letters.

Crystal Structures of N-Acetylmannosamine Kinase Provide Insights into Enzyme Activity and Inhibition*

W. Saenger, S. Moniot, W. Reutter, 2012, The Journal of Biological Chemistry.

A conserved NAD+ binding pocket that regulates protein-protein interactions during aging

L. Aravind, Vera Gorbunova, L. Aravind, 2017, Science.

Molecular architecture of the human protein deacetylase Sirt1 and its regulation by AROS and resveratrol

S. Mosalaganti, S. Moniot, C. Steegborn, 2013, Bioscience reports.

Crystal structures of human soluble adenylyl cyclase reveal mechanisms of catalysis and of its activation through bicarbonate

M. Weyand, S. Moniot, C. Steegborn, 2014, Proceedings of the National Academy of Sciences.

KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients

S. Hersch, S. Tabrizi, B. Leavitt, 2017, Proceedings of the National Academy of Sciences.

The mechanism of sirtuin 2–mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease

Deborah Penque, Stefan Becker, Laetitia Francelle, 2017, PLoS biology.

Crystal structure analysis of human Sirt2 and its ADP-ribose complex.

S. Moniot, C. Steegborn, M. Schutkowski, 2013, Journal of structural biology.

Crystal structures of two solute receptors for L-cystine and L-cysteine, respectively, of the human pathogen Neisseria gonorrhoeae.

W. Saenger, S. Moniot, F. Scheffel, 2012, Journal of molecular biology.

Correction: The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease

S. Kügler, H. Lashuel, S. Becker, 2017, PLoS biology.

SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models.

R. Abagyan, J. Marsh, J. Landers, 2016, Cell chemical biology.

Structural basis for natural lactonase and promiscuous phosphotriesterase activities

G. Manco, J. Dupuy, P. Masson, 2008 .

Crystallization and preliminary crystal structure analysis of the ligand-binding domain of PqsR (MvfR), the Pseudomonas quinolone signal (PQS) responsive quorum-sensing transcription factor of Pseudomonas aeruginosa.

M. Weyand, S. Moniot, W. Blankenfeldt, 2012, Acta crystallographica. Section F, Structural biology and crystallization communications.

KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients

S. Hersch, S. Tabrizi, B. Leavitt, 2017, Proceedings of the National Academy of Sciences.

A conserved NAD+ binding pocket that regulates protein-protein interactions during aging

L. Aravind, D. Sinclair, S. Moniot, 2017, Science.