C. Nathan

发表

Mycobacterium tuberculosis and the host response

S. Kaufmann, S. Cole, V. Mizrahi, 2005, The Journal of experimental medicine.

Peptidomimetic Fluoromethylketone Rescues Mice from Lethal Endotoxic Shock

C. Nathan, S. Grobmyer, R. Armstrong, 1999, Molecular medicine.

Shared actions of endotoxin and taxol on TNF receptors and TNF release.

C. Nathan, A. Ding, F. Porteu, 1990, Science.

Neutrophils and immunity: challenges and opportunities

Carl Nathan, C. Nathan, 2006, Nature Reviews Immunology.

Peripheral inflammatory response in human tuberculosis treatment is predicted by a combination of pathogen sterilization and microbiome dysbiosis

M. Glickman, Y. Taur, V. Bucci, 2020 .

Isocitrate lyase mediates broad antibiotic tolerance in Mycobacterium tuberculosis

C. Nathan, K. Rhee, Madhumitha Nandakumar, 2014, Nature Communications.

Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier.

D. Schnappinger, L. D. de Carvalho, C. Nathan, 2011, Trends in microbiology.

Beyond oxidative stress: an immunologist's guide to reactive oxygen species

C. Nathan, A. Cunningham-Bussel, 2013, Nature Reviews Immunology.

Cooperative development of antimicrobials: looking back to look ahead

C. Nathan, 2015, Nature Reviews Microbiology.

Modulation of Macrophage Function by Transforming Growth Factor β, Interleukin‐4, and Interleukin‐10 a

C. Nathan, C. Bogdan, 1993, Annals of the New York Academy of Sciences.

Whole Cell Screen for Inhibitors of pH Homeostasis in Mycobacterium tuberculosis

C. Nathan, H. Ingólfsson, S. Ehrt, 2013, PloS one.

Production of large amounts of hydrogen peroxide by human tumor cells.

C. Nathan, T. Szatrowski, T. Szatrowski, 1991, Cancer research.

Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity

C. Nathan, H. Murray, M. Wiebe, 1983, The Journal of experimental medicine.

Reactive oxygen and nitrogen intermediates in the relationship between mammalian hosts and microbial pathogens.

C. Nathan, M. Shiloh, C Nathan, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Points of control in inflammation

Carl Nathan, C. Nathan, 2002, Nature.

Cytokines in context

M. Sporn, C. Nathan, 1991, The Journal of cell biology.

Role of interferon regulatory factor 1 in induction of nitric oxide synthase

C. Nathan, E. Martin, E. Martin, 1994, The Journal of experimental medicine.

Metabolomics of Mycobacterium tuberculosis reveals compartmentalized co-catabolism of carbon substrates.

Sabine Ehrt, Carl Nathan, L. D. de Carvalho, 2010, Chemistry & biology.

Nitric oxide as a secretory product of mammalian cells

C. Nathan, C Nathan, 1992, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Advances in Brief A Novel Synthetic Oleanane Triterpenoid , 2-Cyano-3 , 12-dioxoolean-1 , 9-dien-28-oic Acid , with Potent Differentiating , Antiproliferative , and Anti-Inflammatory Activity 1

M. Sporn, E. Dmitrovsky, K. Flanders, 1999 .

A novel synthetic oleanane triterpenoid, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, with potent differentiating, antiproliferative, and anti-inflammatory activity.

M. Sporn, E. Dmitrovsky, K. Flanders, 1999, Cancer research.

Secretory products of macrophages.

C. Nathan, C F Nathan, 1987, The Journal of clinical investigation.

Bacterial infection induces nitric oxide synthase in human neutrophils.

G. Garcı́a-Cardeña, W. Sessa, R. Weiss, 1997, The Journal of clinical investigation.

Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production.

C. Nathan, A. Ding, D. Stuehr, 1988, Journal of immunology.

Phase I trial of recombinant interferon gamma in cancer patients.

C. Nathan, A. Al-Katib, H. Oettgen, 1986, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Transfection with the inducible nitric oxide synthase gene suppresses tumorigenicity and abrogates metastasis by K-1735 murine melanoma cells

I. Fidler, C. Nathan, Suyun Huang, 1995, The Journal of experimental medicine.

SnapShot: Reactive Oxygen Intermediates (ROI)

C. Nathan, A. Ding, 2010, Cell.

Improved Control of Tuberculosis and Activation of Macrophages in Mice Lacking Protein Kinase R

Stanley N Cohen, C. Nathan, Xiuju Jiang, 2012, PloS one.

Is iNOS Beginning to Smoke?

C. Nathan, 2011, Cell.

Inhibition of glutathione synthesis augments lysis of murine tumor cells by sulfhydryl-reactive antineoplastics.

C. Nathan, B. Arrick, Z. Cohn, 1983, The Journal of clinical investigation.

Cytokine-induced respiratory burst of human neutrophils: dependence on extracellular matrix proteins and CD11/CD18 integrins

C. Nathan, S. Wright, E. Sanchez, 1989, The Journal of cell biology.

A semi-automated micro-assay for H2O2 release by human blood monocytes and mouse peritoneal macrophages.

C. Nathan, J. de la Harpe, Carl Nathan, 1985, Journal of immunological methods.

Isolation of a complementary DNA clone encoding a precursor to human eosinophil major basic protein

C. Nathan, N. Ellis, D. Campanelli, 1988, The Journal of experimental medicine.

Agonist and antagonist effects of interferon alpha and beta on activation of human macrophages. Two classes of interferon gamma receptors and blockade of the high-affinity sites by interferon alpha or beta

C. Nathan, H. Murray, R. Yoshida, 1988, The Journal of experimental medicine.

MyD88-5 links mitochondria, microtubules, and JNK3 in neurons and regulates neuronal survival

C. Iadecola, J. Chuang, C. Nathan, 2007, The Journal of experimental medicine.

The macrophage as an effector cell.

C. Nathan, H. Murray, Z. Cohn, 1980, The New England journal of medicine.

Induction of ER Stress in Macrophages of Tuberculosis Granulomas

G. Kaplan, L. Bekker, C. Nathan, 2010, PloS one.

RELEASE OF HYDROGEN PEROXIDE

C. Nathan, 1981 .

The Release of Hydrogen Peroxide from Mononuclear Phagocytes and its Role in Extracellular Cytolysis

C. Nathan, D. Roos, S. Klebanoff, 1980 .

Glutathione metabolism as a determinant of therapeutic efficacy: a review.

C. Nathan, B. Arrick, 1984, Cancer research.

Inhibition of Glutathione Synthesis

C. Nathan, B. Arrick, Z. Cohn, 1983 .

Suppression of arthritis by an inhibitor of nitric oxide synthase

S. Wahl, C. Nathan, J. Albina, 1993, The Journal of experimental medicine.

Aligning pharmaceutical innovation with medical need

C. Nathan, 2007, Nature Medicine.

Role for Nucleotide Excision Repair in Virulence of Mycobacterium tuberculosis

C. Nathan, K. Darwin, 2005, Infection and Immunity.

Differentially Detectable Mycobacterium tuberculosis Cells in Sputum from Treatment-Naive Subjects in Haiti and Their Proportionate Increase after Initiation of Treatment

C. Nathan, J. Pape, L. Mathurin, 2018, mBio.

Genome-Wide Screen for Mycobacterium tuberculosis Genes That Regulate Host Immunity

M. Siddall, D. Schnappinger, C. Nathan, 2010, PloS one.

Benzimidazole-based compounds kill Mycobacterium tuberculosis.

C. Nathan, Xiuju Jiang, Gang Liu, 2014, European journal of medicinal chemistry.

Nitazoxanide kills replicating and nonreplicating Mycobacterium tuberculosis and evades resistance.

L. D. de Carvalho, C. Nathan, Xiuju Jiang, 2009, Journal of medicinal chemistry.

What can immunology contribute to the control of the world's leading cause of death from bacterial infection?

C. Nathan, 2015, Immunological reviews.

E1 of α-ketoglutarate dehydrogenase defends Mycobacterium tuberculosis against glutamate anaplerosis and nitroxidative stress

Anand Balakrishnan, Carl F Nathan, C. Nathan, 2015, Proceedings of the National Academy of Sciences.

Comparison of transposon and deletion mutants in Mycobacterium tuberculosis: The case of rv1248c, encoding 2-hydroxy-3-oxoadipate synthase.

J. Sacchettini, T. Ioerger, C. Nathan, 2015, Tuberculosis.

Characterization of a Mycobacterium tuberculosis proteasomal ATPase homologue

Huilin Li, C. Nathan, Zhiqiang Chen, 2004, Molecular microbiology.

Nonsteroidal anti-inflammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials

C. Nathan, O. Ouerfelli, H. Deng, 2012, Proceedings of the National Academy of Sciences.

Macrophage oxygen-dependent antimicrobial activity. II. The role of oxygen intermediates

C. Nathan, H. Murray, Z. Cohn, 1979, The Journal of experimental medicine.

Recombinant granulocyte/macrophage colony-stimulating factor activates macrophages to inhibit Trypanosoma cruzi and release hydrogen peroxide. Comparison with interferon gamma

S. Reed, C. Nathan, K. Grabstein, 1987, The Journal of experimental medicine.

Extracellular cytolysis by activated macrophages and granulocytes. II. Hydrogen peroxide as a mediator of cytotoxicity

C. Nathan, S. Silverstein, Z. Cohn, 1979, The Journal of experimental medicine.

Conversion of Proepithelin to Epithelins Roles of SLPI and Elastase in Host Defense and Wound Repair

H. Erdjument-Bromage, P. Tempst, G. Ashcroft, 2002, Cell.

New Approaches to Filling the Gap in Tuberculosis Drug Discovery

S. Cole, C. Nathan, M. Casenghi, 2007, PLoS medicine.

Oxathiazolones Selectively Inhibit the Human Immunoproteasome over the Constitutive Proteasome.

C. Nathan, J. Warren, N. Angelo, 2014, ACS medicinal chemistry letters.

Distinct Specificities of Mycobacterium tuberculosis and Mammalian Proteasomes for N-Acetyl Tripeptide Substrates*

L. Dick, C. Nathan, C. Tsu, 2008, Journal of Biological Chemistry.

In Vitro and In Vivo Inhibition of the Mycobacterium tuberculosis Phosphopantetheinyl Transferase PptT by Amidinoureas

J. Sacchettini, J. Vendôme, V. Feher, 2022, Journal of medicinal chemistry.

Structural insights into phosphopantetheinyl hydrolase PptH from Mycobacterium tuberculosis

J. Sacchettini, C. Nathan, J. Mosior, 2019, Protein science : a publication of the Protein Society.

Fellutamide B is a potent inhibitor of the Mycobacterium tuberculosis proteasome.

Huilin Li, C. Nathan, Dongyang Li, 2010, Archives of biochemistry and biophysics.

Evaluation of bacterial survival and phagocyte function with a fluorescence-based microplate assay

C. Nathan, M. Shiloh, J. Ruan, 1997, Infection and immunity.

In vitro differentiation of human macrophages with enhanced antimycobacterial activity.

C. Nathan, G. Vogt, 2011, The Journal of clinical investigation.

Nitazoxanide Disrupts Membrane Potential and Intrabacterial pH Homeostasis of Mycobacterium tuberculosis.

L. D. de Carvalho, C. Nathan, K. Rhee, 2011, ACS medicinal chemistry letters.

An Antibiotic Mimics Immunity

C. Nathan, 2008, Science.

Drug-resistant tuberculosis: a new shot on goal

C. Nathan, 2014, Nature Medicine.

Efficacy of Nitazoxanide against Clinical Isolates of Mycobacterium tuberculosis

C. Nathan, J. Pape, W. Johnson, 2013, Antimicrobial Agents and Chemotherapy.

Structural insights into phosphopantetheinyl hydrolase PptH from Mycobacterium tuberculosis

C. Nathan, J. Mosior, J. Sacchettini, 2020 .

Albumin inhibits neutrophil spreading and hydrogen peroxide release by blocking the shedding of CD43 (sialophorin, leukosialin)

C. Nathan, L. Halbwachs‐Mecarelli, Q. Xie, 1993, The Journal of cell biology.

Inducible nitric oxide synthase‐deficient mice have enhanced leukocyte–endothelium interactions in endotoxemia

P. Kubes, M. Hickey, C. Nathan, 1997, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

NHLBI Workshop Progress and New Directions in Genetics of Tuberculosis An NHLBI Working Group Report

I. Smith, C. Nathan, H. Peavy, 2005 .

Transcriptional adaptation of Mycobacterium tuberculosis within macrophages: Insights into the phagosomal environment JOURNAL OF EXPERIMENTAL MEDICINE

G. Schoolnik, P. Butcher, D. Schnappinger, 2003 .

Putting the brakes on innate immunity: a regulatory role for CD200?

C. Nathan, W. Muller, 2001, Nature Immunology.

Immunology: Oxygen and the inflammatory cell

C. Nathan, 2003, Nature.

Critical Role of the Carboxyl Terminus of Proline-rich Tyrosine Kinase (Pyk2) in the Activation of Human Neutrophils by Tumor Necrosis Factor

C. Nathan, M. Fuortes, Hyunsil Han, 2003, The Journal of experimental medicine.

N-iminoethyl-l-lysine improves memory and reduces amyloid pathology in a transgenic mouse model of amyloid deposition

M. Beal, Michael T. Lin, C. Nathan, 2010, Neurochemistry International.

Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond Citation

Alessandro, Serge, Tyler B. Hughes, 2016 .

Reconstitution of a Mycobacterium tuberculosis proteostasis network highlights essential cofactor interactions with chaperone DnaK

M. Glickman, C. Nathan, C. Adura, 2016, Proceedings of the National Academy of Sciences.

The Moving Frontier in Nitric Oxide–Dependent Signaling

C. Nathan, 2004, Science's STKE.

Potentiation of rifampin activity in a mouse model of tuberculosis by activation of host transcription factor EB

A. Ballabio, K. Chibale, J. Camardo, 2020, PLoS pathogens.

MACROPHAGES K ILL S YNGENEIC M ELANOMA C ELLS UNDER S TRICT A NAEROBIC C ONDITIONS

C. Nathan, C. S. Copeland, S. Silverstein, 1984 .

Target-Based Screen Against a Periplasmic Serine Protease That Regulates Intrabacterial pH Homeostasis in Mycobacterium tuberculosis

Jennifer L. Small, D. Boger, T. Spicer, 2014, ACS chemical biology.

Nonresolving inflammation redux

C. Nathan, 2022, Immunity.

Mycobacterium tuberculosis gene Rv2136c is dispensable for acid resistance and virulence in mice.

C. Nathan, S. Ehrt, Aditya Venugopal, 2011, Tuberculosis.

Mechanism of suppression of nitric oxide synthase expression by interleukin‐4 in primary mouse macrophages

Y. Vodovotz, C. Nathan, C. Bogdan, 1994, Journal of leukocyte biology.

Hemorrhagic tumor necrosis during a pilot trial of tumor necrosis factor-alpha and anti-GD3 ganglioside monoclonal antibody in patients with metastatic melanoma

M. Rosenblum, A. Houghton, P. Chapman, 1994 .

Regulation of biosynthesis of nitric oxide.

C. Nathan, Q. Xie, 1994, The Journal of biological chemistry.

Hydrogen peroxide release from mouse peritoneal macrophages: dependence on sequential activation and triggering

C. Nathan, R. Root, 1977, The Journal of experimental medicine.

Dependence on Sequential Activation and Triggering

C. Nathan, R. Root, 1977 .

Downregulation of tumor necrosis factor receptors on macrophages and endothelial cells by microtubule depolymerizing agents

C. Nathan, A. Ding, F. Porteu, 1990, The Journal of experimental medicine.

Relationship between extracellular stimulation of intracellular killing and oxygen-dependent microbicidal systems of monocytes

C. Nathan, R. van Furth, P. Leijh, 1985, Infection and immunity.

Identification of Nitric Oxide Synthase 2 as an Innate Resistance Locus against Ectromelia Virus Infection

G. Karupiah, C. Nathan, J. MacMicking, 1998, Journal of Virology.

Neutrophils and COVID-19: Nots, NETs, and knots

C. Nathan, 2020, The Journal of experimental medicine.

Inactivation of nitric oxide synthase after prolonged incubation of mouse macrophages with IFN-gamma and bacterial lipopolysaccharide.

Y. Vodovotz, C. Nathan, N. Kwon, 1994, Journal of immunology.

Liver macrophages in murine listeriosis. Cell-mediated immunity is correlated with an influx of macrophages capable of generating reactive oxygen intermediates

R. Steinman, C. Nathan, H. Murray, 1985, The Journal of experimental medicine.

Effects of reagent and cell-generated hydrogen peroxide on the properties of low density lipoprotein.

C. Nathan, R. Montgomery, Z. Cohn, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Periplasmic superoxide dismutase protects Salmonella from products of phagocyte NADPH-oxidase and nitric oxide synthase.

F. Fang, M. Dinauer, C. Nathan, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Suppression of macrophage responses to bacterial lipopolysaccharide by a non-secretory form of secretory leukocyte protease inhibitor.

C. Nathan, A. Ding, J. Zhu, 1999, Biochimica et biophysica acta.

MyD88 Primes Macrophages for Full-Scale Activation by Interferon-γ yet Mediates Few Responses to Mycobacterium tuberculosis

S. Akira, T. Gingeras, J. Drenkow, 2003, The Journal of experimental medicine.

Surmounting structural barriers to tackle endemic infectious diseases

A. Fairlamb, C. Nathan, Félix Calderón, 2021, The Journal of experimental medicine.

Taxol shares the ability of bacterial lipopolysaccharide to induce tyrosine phosphorylation of microtubule-associated protein kinase.

C. Nathan, A. Ding, E. Sanchez, 1993, Journal of immunology.

Extracellular cytolysis by activated macrophages and granulocytes. II. Hydrogen peroxide as a mediator of cytotoxicity

C. Nathan, S. Silverstein, Z. Cohn, 1979, The Journal of experimental medicine.

CHARACTERIZATION OF A LYMPHOCYTE FACTOR WHICH ALTERS MACROPHAGE FUNCTIONS

C. Nathan, J. David, H. Remold, 1973, The Journal of experimental medicine.

Tumor necrosis factor and CD11/CD18 (beta 2) integrins act synergistically to lower cAMP in human neutrophils

C. Nathan, E. Sanchez, E. Sánchez, 1990, The Journal of cell biology.

Human neutrophil elastase releases a ligand-binding fragment from the 75-kDa tumor necrosis factor (TNF) receptor. Comparison with the proteolytic activity responsible for shedding of TNF receptors from stimulated neutrophils.

C. Nathan, D. Wallach, M. Brockhaus, 1991, The Journal of biological chemistry.

Effect of C-2 substitution on the stability of non-traditional cephalosporins in mouse plasma

C. Nathan, M. Zimmerman, J. Aubé, 2019, The Journal of Antibiotics.

Hydrogen peroxide release by alveolar macrophages from sarcoid patients and by alveolar macrophages from normals after exposure to recombinant interferons alpha A, beta, and gamma and 1,25-dihydroxyvitamin D3.

C. Nathan, Z. Cohn, A. Fels, 1987, The Journal of clinical investigation.

Respiratory burst in adherent human neutrophils: triggering by colony- stimulating factors CSF-GM and CSF-G

C. Nathan, 1989 .

Rapid Interferon γ–dependent Clearance of Influenza A Virus and Protection from Consolidating Pneumonitis in Nitric Oxide Synthase 2–deficient Mice

G. Karupiah, C. Nathan, J. MacMicking, 1998, The Journal of experimental medicine.

Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon-gamma and bacterial lipopolysaccharide.

C. Nathan, Q. Xie, 1993, Transactions of the Association of American Physicians.

Nitrite production by stimulated human polymorphonuclear leukocytes supplemented with azide and catalase.

C. Nathan, S. Klebanoff, 1993, Biochemical and biophysical research communications.

of the Macrophage Transcriptome in Response to Interferon- (cid:2) and Mycobacterium tuberculosis : Signaling Roles of Nitric Oxide Synthase-2 and Phagocyte Oxidase

T. Gingeras, J. Drenkow, T. Gaasterland, 2001 .

New Evidence for the Complexity of the Population Structure of Mycobacterium tuberculosis Increases the Diagnostic and Biologic Challenges.

C. Nathan, V. Dartois, Kohta Saito, 2016, American journal of respiratory and critical care medicine.

Lymphokines enhance the capacity of human monocytes to secret reactive oxygen intermediates.

C. Nathan, N. Nogueira, N. Desantis, 1982, The Journal of clinical investigation.

Trace levels of bacterial lipopolysaccharide prevent interferon-gamma or tumor necrosis factor-alpha from enhancing mouse peritoneal macrophage respiratory burst capacity.

C. Nathan, A. Ding, 1987, Journal of immunology.

Intestinal microbiome composition influences the peripheral inflammatory state during treatment of human tuberculosis

M. Glickman, Y. Taur, V. Bucci, 2020 .

Resisting antimicrobial resistance

C. Nathan, 2020, Nature Reviews Microbiology.

ALTERATIONS OF MACROPHAGE FUNCTIONS BY MEDIATORS FROM LYMPHOCYTES

C. Nathan, J. David, M. L. Karnovsky, 1971, The Journal of experimental medicine.

Echocardiographic and survival studies in mice undergoing endotoxic shock: effects of genetic ablation of inducible nitric oxide synthase and pharmacologic antagonism of platelet-activating factor.

R. Devereux, C. Nathan, S. Grobmyer, 1999, The Journal of surgical research.

Antibiotic proteins of human polymorphonuclear leukocytes.

C. Nathan, R. W. Scott, D. Campanelli, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Behavioral deficits and progressive neuropathology in progranulin‐deficient mice: a mouse model of frontotemporal dementia

M. Beal, Michael T. Lin, C. Nathan, 2010 .

Subcellular location and properties of bactericidal factors from human neutrophils

C. Nathan, Z. Cohn, J. Gabay, 1986, The Journal of experimental medicine.

SARM Is Required for Neuronal Injury and Cytokine Production in Response to Central Nervous System Viral Infection

A. García-Sastre, C. Nathan, A. Ding, 2013, The Journal of Immunology.

Catalytic Antibody Bridges Innate and Adaptive Immunity

C. Nathan, 2002, Science.

Transcription and translation of inducible nitric oxide synthase in the pancreas of prediabetic BB rats

H. Kolb, S. Martin, R. Kleemann, 1993, FEBS letters.

Respiratory burst in adherent human neutrophils: triggering by colony-stimulating factors CSF-GM and CSF-G.

C. Nathan, 1989, Blood.

Rethinking immunology

C. Nathan, 2021, Science.

Coordinate Actions of Growth Factors in Monocytes/Macrophages

C. Nathan, 1990 .

Local and systemic effects of intradermal recombinant interferon-gamma in patients with lepromatous leprosy.

R. Steinman, G. Kaplan, C. Nathan, 1986, The New England journal of medicine.

Administration of recombinant interferon gamma to cancer patients enhances monocyte secretion of hydrogen peroxide.

C. Nathan, H. Oettgen, S. Krown, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Hydrogen Peroxide Release by Alveolar Macrophages from Sarcoid Patients and by Alveolar Macrophages from Normals after Exposure to Recombinant Interferons aA, fl, and y and 1 ,25-Dihydroxyvitamin D3

C. Nathan, Z. Cohn, Anna 0. S. FeIs, 2022 .

Chemical inhibitors of TNF signal transduction in human neutrophils point to distinct steps in cell activation

C. Nathan, O. Lou, Julia Roberts, 2006, Journal of leukocyte biology.

Calcium-sensing soluble adenylyl cyclase mediates TNF signal transduction in human neutrophils

C. Nathan, N. Gautam, W. Muller, 2005, The Journal of experimental medicine.

Role of the tyrosine kinase pyk2 in the integrin-dependent activation of human neutrophils by TNF.

G. Lyon, C. Nathan, Maxine Melchior, 1999, The Journal of clinical investigation.

Hemorrhagic tumor necrosis during a pilot trial of tumor necrosis factor-alpha and anti-GD3 ganglioside monoclonal antibody in patients with metastatic melanoma.

L. Minasian, M. Rosenblum, A. Houghton, 1994, Blood.

Analysis of the nonfunctional respiratory burst in murine Kupffer cells

C. Nathan, A. Ding, Carl Nathan, 1988, The Journal of experimental medicine.

Activation of mouse peritoneal macrophages by monoclonal antibodies to Mac-1 (complement receptor type 3)

C. Nathan, S. Wright, A. Ding, 1987, The Journal of experimental medicine.

AGONIST AND ANTAGONIST EFFECTS OF INTERFERON a AND # ON ACTIVATION OF HUMAN MACROPHAGES Two Classes of Interferon y Receptors and Blockade of the High-Affinity Sites by Interferon a or

C. Nathan, H. Murray, 2022 .

Enzymatic basis of macrophage activation. Kinetic analysis of superoxide production in lysates of resident and activated mouse peritoneal macrophages and granulocytes.

C. Nathan, S. Tsunawaki, 1984, The Journal of biological chemistry.

Suppression of macrophage oxidative metabolism by products of malignant and nonmalignant cells

C. Nathan, A. Szuro-Sudol, 1982, The Journal of experimental medicine.

Hydrogen peroxide metabolism in human monocytes during differentiation in vitro.

C. Nathan, Z. Cohn, A. Nakagawara, 1981, The Journal of clinical investigation.

Complementation analysis of mutants of nitric oxide synthase reveals that the active site requires two hemes.

C. Nathan, S. Sassa, Q. Xie, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Pulmonary Nodules in an Infliximab-Treated Rheumatoid Arthritis Patient

D. Flieder, C. Nathan, A. Bass, 2007, HSS Journal.

Metchnikoff's Legacy in 2008

C. Nathan, 2008, Nature Immunology.

TREM-1: A new regulator of innate immunity in sepsis syndrome

C. Nathan, A. Ding, 2001, Nature Medicine.

Murine Kupffer cells. Mononuclear phagocytes deficient in the generation of reactive oxygen intermediates

R. Steinman, C. Nathan, H. Murray, 1985, The Journal of experimental medicine.

Noncytotoxic Inhibition of the Immunoproteasome Regulates Human Immune Cells In Vitro and Suppresses Cutaneous Inflammation in the Mouse

C. Nathan, F. Barrat, T. Pannellini, 2021, The Journal of Immunology.

A Journey in Science: Promise, Purpose, Privilege

C. Nathan, 2013, Molecular medicine.

Differential stimulation of murine lymphoma growth in vitro by normal and BCG-activated macrophages

C. Nathan, W. Terry, 1975, The Journal of experimental medicine.

Carboxyl terminus of inducible nitric oxide synthase. Contribution to NADPH binding and enzymatic activity.

K. O. Elliston, M. Baum, J. Weidner, 1994, The Journal of biological chemistry.

Peroxide and pteridine: a hypothesis on the regulation of macrophage antimicrobial activity by interferon gamma.

C. Nathan, 1986, Interferon.

A Multistress Model for High Throughput Screening Against Nonreplicating Mycobacterium tuberculosis.

C. Nathan, Thulasi Warrier, B. Gold, 2021, Methods in molecular biology.

A multi-stress model for high throughput screening against non-replicating Mycobacterium tuberculosis.

C. Nathan, Thulasi Warrier, B. Gold, 2015, Methods in molecular biology.

Design, Synthesis, and Optimization of Macrocyclic Peptides as Species-Selective Antimalaria Proteasome Inhibitors.

J. Vendôme, M. Michino, C. Nathan, 2022, Journal of medicinal chemistry.

Distinct Specificities of Mycobacterium tuberculosis and Mammalian Proteasomes for N-Acetyl Tripeptide Substrates*

L. Dick, C. Nathan, C. Tsu, 2008, Journal of Biological Chemistry.

Fatal Cytomegalovirus Infection in an Adult with Inherited NOS2 Deficiency.

J. Casanova, C. Nathan, B. Bigio, 2020, The New England journal of medicine.

Lethality of endotoxin in mice genetically deficient in the respiratory burst oxidase, inducible nitric oxide synthase, or both.

M. Dinauer, C. Nathan, M. Shiloh, 1999, Shock.

A protecting group-free synthesis of deazathiamine: a step toward inhibitor design.

L. D. de Carvalho, C. Nathan, Hong Zhao, 2010, Bioorganic & medicinal chemistry letters.

Cytosolic Phospholipase A2 Enzymes Are Not Required by Mouse Bone Marrow-Derived Macrophages for the Control of Mycobacterium tuberculosis In Vitro

M. Gelb, C. Nathan, S. Ehrt, 2006, Infection and Immunity.

Man is not a mouse: reply

F. Fang, C. Nathan, 2007, Journal of leukocyte biology.

Nitric oxide and biopterin: a study in Chiaroscuro.

C. Nathan, 1994, The Journal of clinical investigation.

A Novel Antioxidant Gene from Mycobacterium tuberculosis

C. Nathan, M. Shiloh, S. Ehrt, 1997, The Journal of experimental medicine.

Mechanisms of macrophage antimicrobial activity.

C. Nathan, Carl Nathan, 1983, Transactions of the Royal Society of Tropical Medicine and Hygiene.

Resistance of human tumor cells in vitro to oxidative cytolysis.

C. Nathan, J. O’Donnell-Tormey, C. J. DeBoer, 1985, The Journal of clinical investigation.

Cytokine Production in Response to Central SARM Is Required for Neuronal Injury and

A. García-Sastre, C. Nathan, A. Ding, 2013 .

Lung surfactant and reactive oxygen-nitrogen species: antimicrobial activity and host-pathogen interactions.

F. Fang, C. Nathan, D. Voelker, 2001, American journal of physiology. Lung cellular and molecular physiology.

EB2001 symposium report Lung surfactant and reactive oxygen-nitrogen species: antimicrobial activity and host-pathogen interactions

F. Fang, C. Nathan, D. Voelker, 2001 .

Macrophage activation revisited.

C. Nathan, A. Celada, A. Celada, 1994, Immunology today.

Rapid Interferon (cid:103) –dependent Clearance of Inﬂuenza A Virus and Protection from Consolidating Pneumonitis in Nitric Oxide Synthase 2–deﬁcient Mice

G. Karupiah, C. Nathan, J. MacMicking, 1998 .

A Macrophage Product Responsible for Cytostasis and Respiratory

C. Nathan, 1989 .

Acid Resistance in Mycobacterium tuberculosis (cid:1)

C. Nathan, S. Ehrt, O. Vandal, 2009 .

Characterization of Differentially Detectable Mycobacterium tuberculosis in the Sputum of Subjects with Drug-Sensitive or Drug-Resistant Tuberculosis before and after Two Months of Therapy

C. Nathan, K. Zainabadi, J. Pape, 2021, Antimicrobial agents and chemotherapy.

Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon gamma and bacterial lipopolysaccharide

C. Nathan, Q. Xie, R. Whisnant, 1993, The Journal of experimental medicine.

Inducible nitric oxide synthase: regulation subserves function.

C. Nathan, 1995, Current topics in microbiology and immunology.

Regulation of macrophage functions by macrophage deactivating factor, a tumor cell-derived cytokine

Y. Vodovotz, C. Nathan, C. Bogdan, 1992 .

Experimental visceral leishmaniasis: production of interleukin 2 and interferon-gamma, tissue immune reaction, and response to treatment with interleukin 2 and interferon-gamma.

K. Welte, C. Nathan, H. Murray, 1987, Journal of immunology.

Hydrogen Peroxide Metabolism in Human

C. Nathan, Z. Cohn, 1981 .

Glutathione depletion sensitizes tumor cells to oxidative cytolysis.

C. Nathan, O. Griffith, B. Arrick, 1982, The Journal of biological chemistry.

Inhibition of viral replication by interferon-gamma-induced nitric oxide synthase.

G. Karupiah, C. Nathan, R. Buller, 1993, Science.

Inducible nitric oxide synthase in pulmonary alveolar macrophages from patients with tuberculosis

N. Boéchat, W. Rom, J. Weidner, 1996, The Journal of experimental medicine.

Macrophage oxygen-dependent antimicrobial activity. IV. Role of endogenous scavengers of oxygen intermediates

C. Nathan, H. Murray, Z. Cohn, 1980, The Journal of experimental medicine.

Role of oxygen-dependent mechanisms in antibody-induced lysis of tumor cells by activated macrophages

C. Nathan, Z. Cohn, 1980, The Journal of experimental medicine.

Activation of macrophages in vivo and in vitro. Correlation between hydrogen peroxide release and killing of Trypanosoma cruzi

C. Nathan, Z. Cohn, N. Nogueira, 1979, The Journal of experimental medicine.

Deactivation of macrophages by transforming growth factor-beta.

M. Sporn, C. Nathan, A. Ding, 1988, Nature.

Correction: Improved Control of Tuberculosis and Activation of Macrophages in Mice Lacking Protein Kinase R

Stanley N Cohen, C. Nathan, Xiuju Jiang, 2018, PloS one.

Identification of new inhibitors of protein kinase R guided by statistical modeling.

J. Griffin, C. Nathan, E. Anderson, 2011, Bioorganic & medicinal chemistry letters.

Comparison of transforming growth factor-beta and a macrophage- deactivating polypeptide from tumor cells. Differences in antigenicity and mechanism of action.

M. Sporn, C. Nathan, S. Tsunawaki, 1989, Journal of immunology.

Secretion of oxygen intermediates: role in effector functions of activated macrophages.

C. Nathan, 1982, Federation proceedings.

Metabolic Enzymes of Mycobacteria Linked to Antioxidant Defense by a Thioredoxin-Like Protein

C D Lima, H. Erdjument-Bromage, P. Tempst, 2002, Science.

Interactions of bacterial lipopolysaccharide with microtubule proteins.

C. Nathan, A. Ding, E. Sanchez, 1992, Journal of immunology.

Secretory products of macrophages: twenty-five years on.

C. Nathan, 2012, The Journal of clinical investigation.

Macrophage deactivation. Altered kinetic properties of superoxide- producing enzyme after exposure to tumor cell-conditioned medium

C. Nathan, S. Tsunawaki, Carl Nathan, 1986, The Journal of experimental medicine.

Macrophage activation: some questions.

C. Nathan, 1986, Annales de l'Institut Pasteur. Immunologie.

Regulation of macrophage oxidative metabolism and antiparasitic activity

C. Nathan, 1985 .

Ceramide selectively inhibits early events in the response of human neutrophils to tumor necrosis factor

C. Nathan, M. Fuortes, Wen-Wen Jin, 1996, Journal of leukocyte biology.

human neutrophils to tumor necrosis factor

C. Nathan, W. Jin, M. Fuortes, 1996 .

Biological activities of a human pluripotent hemopoietic colony-stimulating factor.

J. Gabrilove, R. Mertelsmann, K. Welte, 1985, Haematology and blood transfusion.

Macrophage deactivation by interleukin 10

Y. Vodovotz, C. Nathan, C. Bogdan, 1991, The Journal of experimental medicine.

E. coli expression of highly active recombinant murine interleukin-10

C. Nathan, C. Bogdan, B. Holskin, 1993 .

Suppression of macrophage antimicrobial activity by a tumor cell product.

C. Nathan, H. Murray, A. Szuro-Sudol, 1983, Journal of immunology.

The profit problem in antibiotic R&D

C. Nathan, F. M. Goldberg, 2005, Nature Reviews Drug Discovery.

Treatment of patients with chronic granulomatous disease with recombinant human interferon‐gamma does not improve neutrophil oxidative metabolism, cytochrome b558 content or levels of four anti‐microbial proteins

V. Wahn, C. Nathan, H. Schroten, 1992, Clinical and experimental immunology.

Hydrogen peroxide and cytolytic factor can interact synergistically in effecting cytolysis of neoplastic targets.

W. J. Johnson, C. Nathan, D. Adams, 1981, Journal of immunology.

Macrophage oxygen-dependent antimicrobial activity. IV. Role of endogenous scavengers of oxygen intermediates

C. Nathan, H. Murray, Z. Cohn, 1980, The Journal of experimental medicine.

Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells

C. Nathan, D. Stuehr, D J Stuehr, 1989, The Journal of experimental medicine.

Inhibition of Tumor Cell Ribonucleotide Reductase by Macrophage-derived Nitric Oxide By Nyoun

C. Nathan, N. Kwon, D. Stuehr, 2003 .

Participation of the cytoskeleton in macrophage responses to LPS

C. Nathan, A. Ding, 1992 .

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond

Manuel Llinás, George Papadatos, Sundari Suresh, 2016, PLoS pathogens.

Secretory leukocyte protease inhibitor, an inhibitor of neutrophil activation, is elevated in serum in human sepsis and experimental endotoxemia

L. Hydo, P. Barie, S. Lowry, 2000, Critical care medicine.

Nitric oxide and macrophage function.

C. Nathan, J. MacMicking, Q. Xie, 1997, Annual review of immunology.

Phenotype of mice and macrophages deficient in both phagocyte oxidase and inducible nitric oxide synthase.

M. Dinauer, C. Nathan, M. Shiloh, 1999, Immunity.

Reprogramming of the Macrophage Transcriptome in Response to Interferon-γ and Mycobacterium tuberculosis

T. Gingeras, J. Drenkow, T. Gaasterland, 2001, The Journal of experimental medicine.

Reprogramming of the macrophage transcriptome in response to interferon-gamma and Mycobacterium tuberculosis: signaling roles of nitric oxide synthase-2 and phagocyte oxidase.

T. Gingeras, J. Drenkow, T. Gaasterland, 2001, The Journal of experimental medicine.

Macrophage Microbicidal Mechanisms In Vivo: Reactive Nitrogen versus Oxygen Intermediates in the Killing of Intracellular Visceral Leishmania donovani

C. Nathan, H. Murray, 1999, The Journal of experimental medicine.

Secretory Leukocyte Protease Inhibitor: A Macrophage Product Induced by and Antagonistic to Bacterial Lipopolysaccharide

D. Radzioch, C. Nathan, A. Ding, 1997, Cell.

dSarm/Sarm1 Is Required for Activation of an Injury-Induced Axon Death Pathway

Mary A. Logan, Robert H. Brown, S. Züchner, 2012, Science.

Novel Cephalosporins Selectively Active on Nonreplicating Mycobacterium tuberculosis

C. Nathan, M. Zimmerman, J. Aubé, 2016, Journal of medicinal chemistry.

Antibiotics at the crossroads

C. Nathan, 2004, Nature.

Synthetic calanolides with bactericidal activity against replicating and nonreplicating Mycobacterium tuberculosis.

C. Nathan, Gang Liu, S. J. Brickner, 2014, Journal of medicinal chemistry.

Nonresolving Inflammation

Carl Nathan, C. Nathan, A. Ding, 2010, Cell.

Identification of β-Lactams Active against Mycobacterium tuberculosis by a Consortium of Pharmaceutical Companies and Academic Institutions

Robert H Bates, M. Vieth, P. Hipskind, 2022, ACS infectious diseases.

Derivatives of Natural Product Agrimophol as Disruptors of Intrabacterial pH Homeostasis in Mycobacterium tuberculosis.

C. Nathan, B. Javid, Hongshuang Li, 2019, ACS infectious diseases.

Antibiotic resistance--problems, progress, and prospects.

Carl Nathan, O. Cars, C. Nathan, 2014, The New England journal of medicine.

Killing of non-replicating Mycobacterium tuberculosis by 8-hydroxyquinoline.

C. Nathan, Crystal M. Darby, 2010, The Journal of antimicrobial chemotherapy.

Dual-Pharmacophore Pyrithione-Containing Cephalosporins Kill Both Replicating and Nonreplicating Mycobacterium tuberculosis.

C. Nathan, M. Zimmerman, J. Aubé, 2019, ACS infectious diseases.

Effect of C-2 substitution on the stability of non-traditional cephalosporins in mouse plasma

C. Nathan, M. Zimmerman, J. Aubé, 2019, The Journal of Antibiotics.

The high‐output nitric oxide pathway: role and regulation

C. Nathan, Q. Xie, 1994, Journal of leukocyte biology.

Nitric oxide synthases: Roles, tolls, and controls

Carl Nathan, C. Nathan, Q. Xie, 1994, Cell.

Acid Resistance in Mycobacterium tuberculosis

Sabine Ehrt, C. Nathan, S. Ehrt, 2009, Journal of bacteriology.

A membrane protein preserves intrabacterial pH in intraphagosomal Mycobacterium tuberculosis

D. Schnappinger, C. Nathan, S. Ehrt, 2008, Nature Medicine.

Inhibition of tumor cell ribonucleotide reductase by macrophage-derived nitric oxide

C. Nathan, N. Kwon, D. Stuehr, 1991, The Journal of experimental medicine.

Role of nitric oxide synthesis in macrophage antimicrobial activity.

C. Nathan, J. Hibbs, 1991, Current opinion in immunology.

Neutrophil activation on biological surfaces. Massive secretion of hydrogen peroxide in response to products of macrophages and lymphocytes.

C. Nathan, 1987, The Journal of clinical investigation.

Mechanisms of suppression of macrophage nitric oxide release by transforming growth factor beta

Y. Vodovotz, C. Nathan, C. Bogdan, 1993, The Journal of experimental medicine.

Role of activated macrophages in antibody-dependent lysis of tumor cells

G. Kaplan, C. Nathan, Z. Cohn, 1980, The Journal of experimental medicine.

Fresh Approaches to Anti-Infective Therapies

Carl Nathan, C. Nathan, 2012, Science Translational Medicine.

Deactivation of macrophages by transforming growth factor-β

M. Sporn, C. Nathan, A. Ding, 1988, Nature.

Cryptococcal osteomyelitis treated with 5-fluorocytosine.

C. Nathan, 1974, The American review of respiratory disease.

Mobilizable intracellular pool of p55 (type I) tumor necrosis factor receptors in human neutrophils

C. Nathan, F. Porteu, 1992, Journal of leukocyte biology.

Characterization of the nonphagocytic adherent cell from the peritoneal cavity of normal and BCG-treated mice.

C. Nathan, R. Asofsky, W. Terry, 1977, Journal of immunology.

Isolation of a subpopulation of adherent peritoneal cells with anti-tumour activity

C. Nathan, W. Terry, V. M. Hill, 1976, Nature.

Does endothelium-derived nitric oxide have a role in cytokine-induced hypotension?

C. Nathan, D. Stuehr, 1990, Journal of the National Cancer Institute.

Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase

C. Nathan, Howard Y. Chen, G. Hom, 1995, Cell.

Cloning and characterization of inducible nitric oxide synthase from mouse macrophages.

Terry D. Lee, C. Nathan, A. Ding, 1992, Science.

Targeting Phenotypically Tolerant Mycobacterium tuberculosis.

C. Nathan, B. Gold, 2017, Microbiology spectrum.

Decreased phagocytosis by peritoneal macrophages from BCG-treated mice: induction of the phagocytic defect in normal macrophages with BCG in vitro.

C. Nathan, W. Terry, 1977, Cellular immunology.

USE OF LIDOCAINE FOR DETACHMENT OF ADHERENT MONONUCLEAR PHAGOCYTES

C. Nathan, 1981 .

Macrophages secrete a novel heparin-binding protein with inflammatory and neutrophil chemokinetic properties

L. Moldawer, S. Lowry, B. Beutler, 1988, The Journal of experimental medicine.

Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: an FAD- and FMN-containing flavoprotein.

C. Nathan, N. Kwon, D. Stuehr, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Novel triterpenoids suppress inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (COX-2) in mouse macrophages.

M. Sporn, C. Nathan, N. Suh, 1998, Cancer research.

The Proteasome of Mycobacterium tuberculosis Is Required for Resistance to Nitric Oxide

C. Nathan, J. Gutiérrez-Ramos, S. Ehrt, 2003, Science.

Influence of Allosteric Regulators on Individual Steps in the Reaction Catalyzed by Mycobacterium tuberculosis 2-Hydroxy-3-oxoadipate Synthase*

C. Nathan, F. Jordan, Anand Balakrishnan, 2013, The Journal of Biological Chemistry.

Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages

Yang Liu, Philip D. Butcher, Sabine Ehrt, 2003, The Journal of experimental medicine.

Peroxynitrite reductase activity of bacterial peroxiredoxins

Patrick Griffin, Carl Nathan, P. Griffin, 2000, Nature.

Reduced biopterin as a cofactor in the generation of nitrogen oxides by murine macrophages.

C. Nathan, N. Kwon, D. Stuehr, 1989, The Journal of biological chemistry.

HYDROGEN PEROXIDE SECRETION BY MACROPHAGES AS A MARKER OF ACTIVATION AND A MEDIATOR OF CYTOLYSIS: ROLE OF TUMOR CELL ANTIOXIDANT DEFENSES

C. Nathan, 1982 .

Properties of resident and inflammatory macrophages in mouse liver

R. Steinman, C. Nathan, H. Murray, 1985 .

Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice

C. Iadecola, M. Beal, Xiaojing Ma, 2010, The Journal of experimental medicine.

Reactive nitrogen intermediates and the pathogenesis of Salmonella and mycobacteria.

C. Nathan, M. Shiloh, C F Nathan, 2000, Current opinion in microbiology.

Identification of nitric oxide synthase as a protective locus against tuberculosis.

J. Mudgett, C. Nathan, J. MacMicking, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Activation of human macrophages. Comparison of other cytokines with interferon-gamma

R. Mertelsmann, K. Welte, C. Nathan, 1984, Journal of Experimental Medicine.

Release of arachidonate and reduction of oxygen. Independent metabolic bursts of the mouse peritoneal macrophage.

C. Nathan, S. Tsunawaki, 1986, The Journal of biological chemistry.

Activation of mouse peritoneal macrophages in vitro and in vivo by interferon-gamma.

C. Nathan, H. Murray, G. Spitalny, 1985, Journal of immunology.

The measurement of cytochrome b559 in polymorphonuclear leukocytes and macrophages in the presence of hemoglobin or mitochondrial cytochromes.

C. Nathan, A. Ding, 1988, Analytical biochemistry.

Identification of Rv3852 as an Agrimophol-Binding Protein in Mycobacterium tuberculosis

C. Nathan, S. Ehrt, Crystal M. Darby, 2015, PloS one.

Perspectives Series : Nitric Oxide and Nitric Oxide Synthases Inducible Nitric Oxide Synthase : What Difference Does It Make ?

C. Nathan, C Nathan, 2013 .

Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase.

C. Nathan, Q. Xie, Y. Kashiwabara, 1994, The Journal of biological chemistry.

Cellular responses to the intradermal injection of recombinant human gamma-interferon in lepromatous leprosy patients.

G. Kaplan, C. Nathan, E. Sarno, 1987, The American journal of pathology.

TLR4-Dependent Responses to Endogenous, Selective Disadvantage: Genetic Evidence for TLR4-Deficient Macrophages Imposes a Abrupt Expression of TLR4 in

D. Radzioch, C. Nathan, A. Ding, 2013 .

Abrupt Expression of TLR4 in TLR4-Deficient Macrophages Imposes a Selective Disadvantage: Genetic Evidence for TLR4-Dependent Responses to Endogenous, Nonmicrobial Stimuli1

D. Radzioch, C. Nathan, A. Ding, 2006, The Journal of Immunology.

Nonmicrobial Stimuli TLR 4-Dependent Responses to Endogenous , Selective Disadvantage : Genetic Evidence for TLR 4-Deficient Macrophages Imposes a Abrupt Expression of TLR 4 in

D. Radzioch, C. Nathan, A. Ding, 2005 .

Secretion of toxic oxygen products by macrophages: regulatory cytokines and their effects on the oxidase.

C. Nathan, S. Tsunawaki, Carl F. Nathan, 1986, Ciba Foundation symposium.

A simple method for counting adherent cells: application to cultured human monocytes, macrophages and multinucleated giant cells.

C. Nathan, A. Nakagawara, Akira Nakagawara, 1983, Journal of immunological methods.

Genetic regulation of vesiculogenesis and immunomodulation in Mycobacterium tuberculosis

A. Casadevall, O. Elemento, Huilin Li, 2013, Proceedings of the National Academy of Sciences.

CHARACTERIZATION OF A LYMPHOCYTE FACTOR WHICH ALTERS MACROPHAGE FUNCTIONS

C. Nathan, J. David, H. Remold, 1973, The Journal of experimental medicine.

Nonredundant functions of Mycobacterium tuberculosis chaperones promote survival under stress

E. Rubin, C. Nathan, S. Ehrt, 2020, Molecular microbiology.

Biology of antimicrobial resistance and approaches to combat it

C. Nathan, Julien Vaubourgeix, Sarah M Schrader, 2020, Science Translational Medicine.

Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance

M. Foley, P. Rosenthal, P. Bhanot, 2018, Proceedings of the National Academy of Sciences.

Traces of bacterial lipopolysaccharide suppress IFN-gamma-induced nitric oxide synthase gene expression in primary mouse macrophages.

Y. Vodovotz, C. Nathan, C. Bogdan, 1993, Journal of immunology.

Behavioral deficits and progressive neuropathology in progranulin‐deficient mice: a mouse model of frontotemporal dementia

M. Beal, C. Nathan, Rebecca Banerjee, 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Peptide methionine sulfoxide reductase: structure, mechanism of action, and biological function.

B. Matthews, Frantzy Etienne, N. Brot, 2002, Archives of biochemistry and biophysics.

Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs 1

C. Nathan, N. Kwon, D. Stuehr, 1991, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Mechanisms and modulation of macrophage activation.

C. Nathan, 1991, Behring Institute Mitteilungen.

Nitric oxide suppression of human hematopoiesis in vitro. Contribution to inhibitory action of interferon-gamma and tumor necrosis factor-alpha.

N. Young, C. Nathan, C. Selleri, 1995, The Journal of clinical investigation.

Gram‐negative endotoxin: an extraordinary lipid with profound effects on eukaryotic signal transduction 1

C. Nathan, C. Raetz, S. Wright, 1991, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Essential Role of Induced Nitric Oxide in the Initiation of the Inflammatory Response after Hemorrhagic Shock

A. Peitzman, D. Tweardy, T. Billiar, 1998, The Journal of experimental medicine.

Lipoamide channel-binding sulfonamides selectively inhibit mycobacterial lipoamide dehydrogenase.

Chi‐Huey Wong, P. Hipskind, C. Lima, 2013, Biochemistry.

Identification of arginine as a precursor of endothelium-derived relaxing factor.

C. Nathan, D. Stuehr, S. Gross, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Shedding of tumor necrosis factor receptors by activated human neutrophils

C. Nathan, F. Porteu, FranyoisePorteuand Carl Nathan, 1990, The Journal of experimental medicine.

Rifamycin action on RNA polymerase in antibiotic-tolerant Mycobacterium tuberculosis results in differentially detectable populations

W. Jacobs, C. Nathan, Lina Kaminski, 2017, Proceedings of the National Academy of Sciences.

Variant tricarboxylic acid cycle in Mycobacterium tuberculosis: identification of alpha-ketoglutarate decarboxylase.

Makoto Suematsu, Carl Nathan, M. Suematsu, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Bacillus Calmette-Guerin-activated murine macrophages kill syngeneic melanoma cells under strict anaerobic conditions

C. Nathan, C. S. Copeland, S. Silverstein, 1984, The Journal of experimental medicine.

Oxidative damage and delayed replication allow viable Mycobacterium tuberculosis to go undetected

C. Nathan, Xiuju Jiang, Kohta Saito, 2021, Science Translational Medicine.

Peptide methionine sulfoxide reductase from Escherichia coli and Mycobacterium tuberculosis protects bacteria against oxidative damage from reactive nitrogen intermediates

N. Brot, H. Weissbach, H. Erdjument-Bromage, 2001, Proceedings of the National Academy of Sciences of the United States of America.

N omega-hydroxy-L-arginine is an intermediate in the biosynthesis of nitric oxide from L-arginine.

C. Nathan, N. Kwon, O. Griffith, 1991, The Journal of biological chemistry.

Triazaspirodimethoxybenzoyls as selective inhibitors of mycobacterial lipoamide dehydrogenase .

C. Lima, C. Nathan, R. Bryk, 2010, Biochemistry.

Identification of a Mycothiol-Dependent Nitroreductase from Mycobacterium tuberculosis

J. Sacchettini, T. Ioerger, J. Vendôme, 2018, ACS infectious diseases.

Crystal Structure and Functional Analysis of Lipoamide Dehydrogenase from Mycobacterium tuberculosis*

C. Lima, J. Buglino, C. Nathan, 2005, Journal of Biological Chemistry.

Identification of a Chemical That Inhibits the Mycobacterial UvrABC Complex in Nucleotide Excision Repair†

B. Van Houten, C. Nathan, N. Mazloum, 2011, Biochemistry.

Type I interferon signaling mediates Mycobacterium tuberculosis–induced macrophage death

C. Nathan, Xiuju Jiang, Yan Ling, 2020, The Journal of experimental medicine.

Contrasting mechanisms for suppression of macrophage cytokine release by transforming growth factor-beta and interleukin-10.

Y. Vodovotz, C. Nathan, C. Bogdan, 1992, The Journal of biological chemistry.

Role of iNOS in Human Host Defense

Carl Nathan, C. Nathan, 2006, Science.

Antimicrobial mechanisms of macrophages

C. Nathan, M. Shiloh, 1992 .

Macrophage deactivating factor and transforming growth factors-beta 1 -beta 2 and -beta 3 inhibit induction of macrophage nitrogen oxide synthesis by IFN-gamma.

R. Derynck, J. Graycar, C. Nathan, 1990, Journal of immunology.

Secretion of pyruvate. An antioxidant defense of mammalian cells

C. Nathan, J. O’Donnell-Tormey, C F Nathan, 1987, The Journal of experimental medicine.

Azurocidin and a homologous serine protease from neutrophils. Differential antimicrobial and proteolytic properties.

C. Nathan, P. Detmers, D. Campanelli, 1990, The Journal of clinical investigation.

Cloning of cDNA for proteinase 3: a serine protease, antibiotic, and autoantigen from human neutrophils

Y. Fu, C. Nathan, Maxine Melchior, 1990, The Journal of experimental medicine.

Mycobacterium tuberculosis appears to lack α‐ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes

H. Erdjument-Bromage, P. Tempst, C. Nathan, 2005, Molecular microbiology.

S-nitroso proteome of Mycobacterium tuberculosis: Enzymes of intermediary metabolism and antioxidant defense.

H. Erdjument-Bromage, P. Tempst, C. Nathan, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Heat shock protein 90 mediates macrophage activation by Taxol and bacterial lipopolysaccharide.

N. Rosen, H. Erdjument-Bromage, P. Tempst, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Specificity of a third kind: reactive oxygen and nitrogen intermediates in cell signaling.

C. Nathan, 2003, The Journal of clinical investigation.

Virulence of Mycobacterium tuberculosis depends on lipoamide dehydrogenase, a member of three multienzyme complexes.

D. Schnappinger, C. Nathan, K. Rhee, 2011, Cell host & microbe.

Identification of a copper-binding metallothionein in pathogenic mycobacteria.

Julia Roberts, Haiteng Deng, Carl Nathan, 2008, Nature chemical biology.

Making space for anti-infective drug discovery.

C. Nathan, 2011, Cell host & microbe.

Inhibitors Selective for Mycobacterial versus Human Proteasomes

Huilin Li, C. Nathan, J. Warren, 2009, Nature.

Role of oxygen in T cell-mediated cytolysis.

C. Nathan, M. Palladino, J. A. Mercer-smith, 1982, Journal of immunology.

Beta 2 integrin-dependent tyrosine phosphorylation of paxillin in human neutrophils treated with tumor necrosis factor

C. Nathan, W. Jin, M. Fuortes, 1994, The Journal of cell biology.

Calmodulin is a subunit of nitric oxide synthase from macrophages

C. Nathan, T. Lee, K. Swiderek, 1992, The Journal of experimental medicine.

Activated Murine Macrophages Secrete a Metabolite of Arginine with the Bioactivity of Endothelium-derived Relaxing Factor and the Chemical Reactivity of Nitric Oxide Materials and Methods

C. Nathan, D. Stuehr, S. Gross, 2022 .

Inducible Nitric Oxide Synthase Requires Both the Canonical Calmodulin-binding Domain and Additional Sequences in Order to Bind Calmodulin and Produce Nitric Oxide in the Absence of Free Ca2+*

C. Nathan, J. Ruan, Q. Xie, 1996, The Journal of Biological Chemistry.

Gastrointestinal microbiota composition predicts peripheral inflammatory state during treatment of human tuberculosis

M. Glickman, Y. Taur, V. Bucci, 2021, Nature Communications.

Molecular mechanisms in tumor-cell killing by activated macrophages.

C. Nathan, D. Adams, 1983, Immunology today.

N-methylation of a bactericidal compound as a resistance mechanism in Mycobacterium tuberculosis

T. Ioerger, C. Nathan, M. Luo, 2016, Proceedings of the National Academy of Sciences.

Identification of Compounds with pH-Dependent Bactericidal Activity against Mycobacterium tuberculosis

Todd R. Wiernicki, P. Hipskind, C. Nathan, 2018, ACS infectious diseases.

Hydrogen peroxide from cellular metabolism of cystine. A requirement for lysis of murine tumor cells by vernolepin, a glutathione-depleting antineoplastic.

C. Nathan, B. Arrick, Z. Cohn, 1985, The Journal of clinical investigation.

Functional channel formation associated with cytotoxic T-cell granules.

J. D. Young, C. Nathan, M. Palladino, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Opposing reactions in coenzyme A metabolism sensitize Mycobacterium tuberculosis to enzyme inhibition

J. Sacchettini, T. Ioerger, D. Schnappinger, 2019, Science.

Inducible nitric oxide synthase in tangle-bearing neurons of patients with Alzheimer's disease

M. Sporn, Y. Vodovotz, K. Flanders, 1996, The Journal of experimental medicine.

Phase I trial of recombinant interferon gamma by 1-hour i.v. infusion.

C. Nathan, H. Oettgen, S. Krown, 1986, Cancer treatment reports.

A glutamate‐alanine‐leucine (EAL) domain protein of Salmonella controls bacterial survival in mice, antioxidant defence and killing of macrophages: role of cyclic diGMP

Roger A. Jones, M. MacCoss, B. Gaffney, 2005, Molecular microbiology.

Epidemic Inflammation: Pondering Obesity

C. Nathan, 2008, Molecular medicine.

Mycobacterium tuberculosis expresses methionine sulphoxide reductases A and B that protect from killing by nitrite and hypochlorite

N. Brot, C. Nathan, Crystal M. Darby, 2009, Molecular microbiology.

L-citrulline production from L-arginine by macrophage nitric oxide synthase. The ureido oxygen derives from dioxygen.

C. Nathan, N. Kwon, O. Griffith, 1990, The Journal of biological chemistry.

Mycobacterium tuberculosis prcBA genes encode a gated proteasome with broad oligopeptide specificity

T. Parsons, Huilin Li, P. Zwickl, 2006, Molecular microbiology.

Structure of the Mycobacterium tuberculosis proteasome and mechanism of inhibition by a peptidyl boronate

Huilin Li, L. Dick, C. Nathan, 2006, Molecular microbiology.

Macrophages rapidly internalize their tumor necrosis factor receptors in response to bacterial lipopolysaccharide.

C. Nathan, A. Ding, E. Sanchez, 1989, The Journal of biological chemistry.

Phenotypic Tolerance and Bacterial Persistence

C. Nathan, 2018 .

Kunkel Lecture: Fundamental immunodeficiency and its correction

C. Nathan, 2017, The Journal of experimental medicine.

Stressed mycobacteria use the chaperone ClpB to sequester irreversibly oxidized proteins asymmetrically within and between cells.

Nicolas Chenouard, M. Unser, D. Schnappinger, 2015, Cell host & microbe.

Identification of genes involved in innate responsiveness to bacterial products by differential display.

C. Nathan, A. Ding, F. Jin, 1998, Methods.

Lipopolysaccharide-Related Stimuli Induce Expression of the Secretory Leukocyte Protease Inhibitor, a Macrophage-Derived Lipopolysaccharide Inhibitor

D. Radzioch, C. Nathan, Fenyu Jin, 1998, Infection and Immunity.

Rapid, Semiquantitative Assay To Discriminate among Compounds with Activity against Replicating or Nonreplicating Mycobacterium tuberculosis

C. Nathan, J. Warren, Thulasi Warrier, 2015, Antimicrobial Agents and Chemotherapy.

CHAPTER 9 – Macrophage-Derived Nitric Oxide: Generation and Consequences

C. Nathan, Q. Xie, 1992 .

Acid-Susceptible Mutants of Mycobacterium tuberculosis Share Hypersusceptibility to Cell Wall and Oxidative Stress and to the Host Environment

D. Schnappinger, C. Nathan, S. Ehrt, 2008, Journal of bacteriology.

Role of nitric oxide in antagonistic effects of transforming growth factor-beta and interleukin-1 beta on the beating rate of cultured cardiac myocytes.

M. Sporn, Y. Vodovotz, A. Roberts, 1992, Molecular endocrinology.

Rational Design of Selective and Bioactive Inhibitors of the Mycobacterium tuberculosis Proteasome.

R. Sauer, J. Sello, C. Nathan, 2017, ACS infectious diseases.

Protection from Alzheimer's-like disease in the mouse by genetic ablation of inducible nitric oxide synthase

M. Beal, Y. Vodovotz, C. Nathan, 2005, The Journal of experimental medicine.

Activity-Based Protein Profiling Reveals That Cephalosporins Selectively Active on Non-replicating Mycobacterium tuberculosis Bind Multiple Protein Families and Spare Peptidoglycan Transpeptidases

J. Sacchettini, C. Nathan, J. Aubé, 2020, Frontiers in Microbiology.

Bactericidal Disruption of Magnesium Metallostasis in Mycobacterium tuberculosis Is Counteracted by Mutations in the Metal Ion Transporter CorA

C. Nathan, J. Aubé, S. Silve, 2019, mBio.

FAD and GSH participate in macrophage synthesis of nitric oxide.

C. Nathan, N. Kwon, D. Stuehr, 1990, Biochemical and biophysical research communications.

A philosophy of anti-infectives as a guide in the search for new drugs for tuberculosis.

C. Nathan, R. Bryk, Aditya Venugopal, 2008, Tuberculosis.

Complementary DNA sequence of human neutrophil azurocidin, an antibiotic with extensive homology to serine proteases.

C. Nathan, Maxine Melchior, D. Campanelli, 1991, Biochemical and biophysical research communications.

Distinct Spatiotemporal Dynamics of Peptidoglycan Synthesis between Mycobacterium smegmatis and Mycobacterium tuberculosis

C. Nathan, O. Ouerfelli, H. Botella, 2017, mBio.

SECRETORY PRODUCTS IN CYTOTOXICITY

C. Nathan, 1983 .

Structure-Activity Relationship Studies of Antimalarial Plasmodium Proteasome Inhibitors─Part II.

M. Foley, J. Vendôme, N. Liverton, 2023, Journal of medicinal chemistry.

Structural insights on the Mycobacterium tuberculosis proteasomal ATPase Mpa.

Chunyan Tang, Huilin Li, C. Nathan, 2009, Structure.

Characterization of Phosphopantetheinyl Hydrolase from Mycobacterium tuberculosis

J. Sacchettini, C. Nathan, O. Ouerfelli, 2021, Microbiology spectrum.

Structure-Activity Relationships of Noncovalent Immunoproteasome β5i-Selective Dipeptides.

Xiaojing Ma, C. Nathan, J. Salmon, 2020, Journal of medicinal chemistry.

TB drug development: immunology at the table

C. Nathan, C. Barry, 2015, Immunological reviews.

Resisting antimicrobial resistance

C. Nathan, 2020, Nature Reviews Microbiology.

Adenosine regulates the respiratory burst of cytokine-triggered human neutrophils adherent to biologic surfaces.

C. Nathan, J. de la Harpe, J. D. L. Harpe, 1989, Journal of immunology.

Artemisinin-based hybrids produce intracellular proteasome inhibitors that overcome resistance in Plasmodium falciparum

C. Nathan, Changmei Yang, L. Kirkman, 2021, bioRxiv.

ATP hydrolysis-coupled peptide translocation mechanism of Mycobacterium tuberculosis ClpB

Huilin Li, C. Nathan, Gongpu Zhao, 2018, Proceedings of the National Academy of Sciences.

Macrophages' Choice: Take It In or Keep It Out.

C. Nathan, 2016, Immunity.

Selective killing of nonreplicating mycobacteria.

M. Gurney, C. Nathan, C. Popescu, 2008, Cell host & microbe.

Nitrite produced by Mycobacterium tuberculosis in human macrophages in physiologic oxygen impacts bacterial ATP consumption and gene expression

C. Nathan, A. Cunningham-Bussel, Tuo Zhang, 2013, Proceedings of the National Academy of Sciences.

Effect of recombinant interferon-gamma on hydrogen peroxide-releasing capacity of monocyte-derived macrophages from patients with lepromatous leprosy.

G. Kaplan, C. Nathan, M. Horwitz, 1986, Journal of immunology.

Identification of Novel Anti-mycobacterial Compounds by Screening a Pharmaceutical Small-Molecule Library against Nonreplicating Mycobacterium tuberculosis.

Gonzalo Colmenarejo, A. Álvarez-Pedraglio, C. Nathan, 2015, ACS infectious diseases.

Structure of human immunoproteasome with a reversible and noncompetitive inhibitor that selectively inhibits activated lymphocytes

Huilin Li, C. Nathan, Kaiming Zhang, 2017, Nature Communications.

Widespread intradermal accumulation of mononuclear leukocytes in lepromatous leprosy patients treated systemically with recombinant interferon gamma

K. Squires, C. Nathan, C. K. Job, 1990, The Journal of experimental medicine.

Selective Phenylimidazole-based Inhibitors of the Mycobacterium tuberculosis Proteasome.

M. Foley, Huilin Li, M. Michino, 2019, Journal of medicinal chemistry.

Nitrite impacts the survival of Mycobacterium tuberculosis in response to isoniazid and hydrogen peroxide

C. Nathan, A. Cunningham-Bussel, F. Bange, 2013, MicrobiologyOpen.

Synthesis of nitrogen oxides from L-arginine by macrophage cytosol: requirement for inducible and constitutive components.

C. Nathan, N. Kwon, D. Stuehr, 1989, Biochemical and biophysical research communications.

Physicochemical characteristics of several mediators from stimulated guinea pig and human lymphocytes.

C. Nathan, J. David, H. Remold, 1972, Transplantation proceedings.

Paradoxical preservation of a lipopolysaccharide response in C3H/HeJ macrophages: induction of matrix metalloproteinase-9.

C. Nathan, A. Ding, F. Jin, 1999, Journal of immunology.

Brief treatment with a highly selective immunoproteasome inhibitor promotes long-term cardiac allograft acceptance in mice

Lei Shi, C. Nathan, J. Azzi, 2016, Proceedings of the National Academy of Sciences.

Identification of Mycobacterium tuberculosis Counterimmune (cim) Mutants in Immunodeficient Mice by Differential Screening

W. Jacobs, James E Gomez, J. Mckinney, 2004, Infection and Immunity.

Multiform antimicrobial resistance from a metabolic mutation

C. Nathan, H. Botella, K. Rhee, 2021, Science advances.

Activity-based metabolomic profiling of enzymatic function: identification of Rv1248c as a mycobacterial 2-hydroxy-3-oxoadipate synthase.

C. Lima, S. Fischer, C. Nathan, 2010, Chemistry & biology.

Vesicle membrane association of nitric oxide synthase in primary mouse macrophages.

Y. Vodovotz, C. Nathan, C. Bogdan, 1995, Journal of immunology.

Cytokine regulation of nitric oxide synthase in mouse retinal pigment epithelial cells in culture.

Y. Vodovotz, C. Nathan, J. Sparrow, 1994, Experimental eye research.

Inducible nitric oxide synthase in the tuberculous human lung.

C. Nathan, 2002, American journal of respiratory and critical care medicine.

Nonredundant Antioxidant Defense by Multiple Two-Cysteine Peroxiredoxins in Human Prostate Cancer Cells

Carl Nathan, C. Nathan, Chuanlu Shen, 2002, Molecular medicine.

Dual-pharmacophore artezomibs hijack the Plasmodium ubiquitin-proteasome system to kill malaria parasites while overcoming drug resistance.

H. Zhang, A. Waters, C. Nathan, 2023, Cell chemical biology.

Development of a highly selective Plasmodium falciparum proteasome inhibitor with anti-malaria activity in humanized mice.

P. Rosenthal, J. Vendôme, M. Michino, 2021, Angewandte Chemie.

Inducible Nitric Oxide Synthase Requires Both the Canonical Calmodulin-binding Domain and Additional Sequences in Order to Bind Calmodulin and Produce Nitric Oxide in the Absence of Free Ca 2

C. Nathan, J. Ruan, Q. Xie, 1996 .

Inducible Nitric Oxide Synthase Requires Both the Canonical Calmodulin-binding Domain and Additional Sequences in Order to Bind Calmodulin and Produce Nitric Oxide in the Absence of Free Ca*

C. Nathan, Q. Xie, N. Hutchinson, 1996 .

noxR3, a Novel Gene fromMycobacterium tuberculosis, Protects Salmonella typhimurium from Nitrosative and Oxidative Stress

C. Nathan, S. Ehrt, L. Riley, 1999, Infection and Immunity.

Correction: Whole Cell Screen for Inhibitors of pH Homeostasis in Mycobacterium tuberculosis

C. Nathan, H. Ingólfsson, O. Andersen, 2013, PLoS ONE.

Evidence for dispensability of protein kinase R in host control of tuberculosis

C. Nathan, R. Bryk, Xiuju Jiang, 2018, European journal of immunology.

Elevation of IL-18 in Human Sepsis

P. Barie, S. Lowry, C. Nathan, 2000, Journal of Clinical Immunology.

Mycobacterium tuberculosis PptT Inhibitors Based on Heterocyclic Replacements of Amidinoureas

J. Sacchettini, C. Nathan, J. Aubé, 2023, ACS Medicinal Chemistry Letters.

Grobmyer, S. R. et al. Peptidomimetic fluoromethylketone rescues mice from lethal endotoxic shock: Paradoxical increase in products of caspase 1 (ICE). Mol. Med. 5, 585−594

C. Nathan, S. Grobmyer, R. Armstrong, 1999 .

(lymphocytes/cell-mediated cytolysis/transmembrane channels/plan

C. Nathan, Z. Cohn, J. Young, 2016 .

N,C-Capped dipeptides with selectivity for mycobacterial proteasome over human proteasomes: role of S3 and S1 binding pockets.

M. Sintchak, L. Dick, C. Nathan, 2013, Journal of the American Chemical Society.

Immunoproteasome β5i‐Selective Dipeptidomimetic Inhibitors

Lei Shi, C. Nathan, P. Singh, 2016, ChemMedChem.

Visualization of the Charcoal Agar Resazurin Assay for Semi-quantitative, Medium-throughput Enumeration of Mycobacteria

C. Nathan, Thulasi Warrier, Julia Roberts, 2016, Journal of visualized experiments : JoVE.

Macrocyclic Peptides that Selectively Inhibit the Mycobacterium tuberculosis Proteasome.

M. Foley, Huilin Li, J. Vendôme, 2021, Journal of medicinal chemistry.

Structural Basis for the Species-Selective Binding of N,C-Capped Dipeptides to the Mycobacterium tuberculosis Proteasome.

Huilin Li, C. Nathan, H. Hsu, 2017, Biochemistry.

Adhesion-dependent protein tyrosine phosphorylation in neutrophils treated with tumor necrosis factor

C. Nathan, W. Jin, M. Fuortes, 1993, The Journal of cell biology.

Transcriptional Biomarkers of Differentially Detectable Mycobacterium tuberculosis in Patient Sputum

C. Nathan, K. Zainabadi, J. Pape, 2022, mBio.

Anti-inflammatory function of secretory leukocyte protease inhibitor

C. Nathan, S. Grobmyer, Aihao Ding, 1999 .

Inducible nitric oxide synthase: identification of amino acid residues essential for dimerization and binding of tetrahydrobiopterin.

C. Nathan, S. Sassa, E. Martin, 1995, Proceedings of the National Academy of Sciences of the United States of America.

A commentary: inducible nitric oxide synthase.

C. Nathan, Carl Nathan, 1991, Research in immunology.

From transient infection to chronic disease

C. Nathan, 2015, Science.

Nonsteroidal anti-inflammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials

C. Nathan, O. Ouerfelli, Ronald B. Realubit, 2012 .

Taming tuberculosis: a challenge for science and society.

Carl Nathan, C. Nathan, 2009, Cell host & microbe.

Activation of human macrophages. Comparison of other cytokines with interferon-gamma

C. Nathan, H. Murray, E. Stanley, 1984, The Journal of experimental medicine.

Points of control in inflammation

C. Nathan, 2002, Nature.

Essential Role of Induced Nitric Oxide in the Initiation of the Inflammatory Response after Hemorrhagic Shock

A. Peitzman, D. Tweardy, T. Billiar, 1998, The Journal of experimental medicine.

Identification of a copper-binding metallothionein in pathogenic mycobacteria.

D. Eliezer, D. Vargas, C. Nathan, 2008, Nature chemical biology.

Cytokines in context

M. Sporn, C. Nathan, Samuel A. Seaver, 1991, The Journal of cell biology.

Cytostasis from nitrite a product of activated macrophages

C. Nathan, D. Stuehr, C. Morris, 1988 .

Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier.

D. Schnappinger, C. Nathan, Joeli Marrero, 2011, Trends in microbiology.

Extracellular cytolysis by activated macrophages and granulocytes. I. Pharmacologic triggering of effector cells and the release of hydrogen peroxide

C. Nathan, S. Silverstein, L. Brukner, 1979, The Journal of experimental medicine.

A Journey in Science: Promise, Purpose, Privilege

C. Nathan, 2013, Molecular Medicine.

Macrophage Microbicidal Mechanisms In Vivo: Reactive Nitrogen versus Oxygen Intermediates in the Killing of Intracellular Visceral Leishmania donovani

C. Nathan, H. Murray, 1999, The Journal of experimental medicine.

AGONIST AND ANTAGONIST EFFECTS OF INTERFERON a AND # ON ACTIVATION OF HUMAN MACROPHAGES Two Classes of Interferon y Receptors and Blockade ofthe

C. Nathan, R. Yoshida, 1988 .

Natural resistance and nitric oxide

C. Nathan, C. Nathan, 1995, Cell.

A novel synthetic oleanane triterpenoid, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, with potent differentiating, antiproliferative, and anti-inflammatory activity.

M. Sporn, E. Dmitrovsky, K. Flanders, 1999, Cancer research.

Critical Role of the Carboxyl Terminus of Proline-rich Tyrosine Kinase (Pyk2) in the Activation of Human Neutrophils by Tumor Necrosis Factor

C. Nathan, M. Fuortes, Hyunsil Han, 2003, The Journal of experimental medicine.

Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice

C. Iadecola, M. Beal, Xiaojing Ma, 2010, The Journal of experimental medicine.

Identification of a Chemical That Inhibits the Mycobacterial UvrABC Complex in Nucleotide Excision Repair†

C. Nathan, N. Mazloum, N. Kwon, 2011, Biochemistry.

MACROPHAGE OXYGEN-DEPENDENT ANTIMICROBIAL ACTIVITY Assay for 1-1202 Generation

C. Nathan, Z. Cohn, 2003 .

Rational Design of Selective and Bioactive Inhibitors of the Mycobacterium tuberculosis Proteasome.

R. Sauer, C. Nathan, Xiuju Jiang, 2017, ACS infectious diseases.