J. Engel

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Lipid Raft-Mediated Entry Is Not Required for Chlamydia trachomatis Infection of Cultured Epithelial Cells

B. Gabel, C. Elwell, S. V. van IJzendoorn, 2004, Infection and Immunity.

Focal adhesion components are essential for mammalian cell cytokinesis

J. Engel, K. Mostov, S. Shafikhani, 2008, Cell cycle.

Role of Pseudomonas aeruginosa type III effectors in disease.

J. Engel, P. Balachandran, Joanne Engel, 2009, Current opinion in microbiology.

Type III protein secretion is associated with poor clinical outcomes in patients with ventilator-associated pneumonia caused by Pseudomonas aeruginosa.

J. Rello, J. Engel, M. Bodí, 2002, Critical care medicine.

Chlamydial rRNA operons: gene organization and identification of putative tandem promoters

J. Engel, D. Ganem, 1987, Journal of bacteriology.

PepA, a secreted protein of Pseudomonas aeruginosa, is necessary for cytotoxicity and virulence

J. Engel, A. Hauser, P. Kang, 1998, Molecular microbiology.

Pseudomonas aeruginosa ExoT Acts In Vivo as a GTPase-Activating Protein for RhoA, Rac1, and Cdc42

J. Engel, B. Kazmierczak, 2002, Infection and Immunity.

Characterization of Pseudomonas aeruginosa-induced MDCK cell injury: glycosylation-defective host cells are resistant to bacterial killing

J. Engel, J. Wiener-Kronish, K. Mostov, 1995, Infection and immunity.

Epithelial cell polarity alters Rho-GTPase responses to Pseudomonas aeruginosa.

J. Engel, K. Mostov, B. Kazmierczak, 2003, Molecular biology of the cell.

The Second Type VI Secretion System of Pseudomonas aeruginosa Strain PAO1 Is Regulated by Quorum Sensing and Fur and Modulates Internalization in Epithelial Cells*

J. Engel, A. Filloux, C. Soscia, 2012, The Journal of Biological Chemistry.

Type IV pili mechanochemically regulate virulence factors in Pseudomonas aeruginosa

H. Stone, J. Engel, Y. Inclán, 2015, Proceedings of the National Academy of Sciences.

Pseudomonas aeruginosa Internalization by Non-Phagocytic Cells

J. Engel, 2007 .

Pseudomonas aeruginosa fimL regulates multiple virulence functions by intersecting with Vfr‐modulated pathways

J. Mattick, S. Beatson, C. Whitchurch, 2005, Molecular microbiology.

Cell migration regulates the kinetics of cytokinesis

J. Engel, S. Shafikhani, G. Sivaramakrishnan, 2011, Cell cycle.

Sugar administration is an effective adjunctive therapy in the treatment of Pseudomonas aeruginosa pneumonia.

J. Engel, M. Matthay, Yuanlin Song, 2013, American journal of physiology. Lung cellular and molecular physiology.

Chlamydia trachomatis effector Dre1 interacts with dynactin to reposition host organelles during infection

Jeffrey R. Johnson, R. Bastidas, R. Valdivia, 2022, bioRxiv.

Subversion of Mucosal Barrier Polarity by Pseudomonas Aeruginosa

J. Engel, Yonatan Eran, 2011, Front. Microbio..

Pseudomonas aeruginosa-Mediated Damage Requires Distinct Receptors at the Apical and Basolateral Surfaces of the Polarized Epithelium

J. Engel, K. Mostov, I. Bucior, 2009, Infection and Immunity.

Pseudomonas aeruginosa-mediated damage requires distinct receptors at the apical 1 and basolateral surfaces of polarized epithelium 2 3 4

J. Engel, K. Mostov, I. Bucior, 2009 .

Chlamydia interfere with an interaction between the mannose-6-phosphate receptor and sorting nexins to counteract host restriction

N. Krogan, Jeffrey R. Johnson, C. Elwell, 2017, eLife.

Cloning andCharacterization ofRNA Polymerase CoreSubunits of Chlamydia trachomatis byUsingthePolymerase ChainReaction

J. Pollack, J. Engel, D. Ganem, 1990 .

Eukaryotic Cell Uptake of Heparin-Coated Microspheres: a Model of Host Cell Invasion by Chlamydia trachomatis

Kathleen A. Kennedy, R. Stephens, J. Engel, 2000, Infection and Immunity.

Host cell polarity proteins participate in innate immunity to Pseudomonas aeruginosa infection.

R. Metzger, J. Engel, K. Mostov, 2014, Cell host & microbe.

The Arginine Finger Domain of ExoT Contributes to Actin Cytoskeleton Disruption and Inhibition of Internalization ofPseudomonas aeruginosa by Epithelial Cells and Macrophages

J. Engel, J. Comolli, B. Kazmierczak, 2000, Infection and Immunity.

FimL Regulates cAMP Synthesis in Pseudomonas aeruginosa

J. Engel, Y. F. Inclán, M. Huseby, 2011, PloS one.

Pseudomonas aeruginosa ExoT inhibits in vitro lung epithelial wound repair

T. Geiser, J. Engel, M. Matthay, 2001, Cellular microbiology.

Interaction of bacterial pathogens with polarized epithelium.

J. Engel, K. Mostov, B. Kazmierczak, 2001, Annual review of microbiology.

Emerging Role of Retromer in Modulating Pathogen Growth.

C. Elwell, J. Engel, 2018, Trends in microbiology.

Both the N- and C- terminal regions of the Chlamydial inclusion protein D (IncD) are required for interaction with the pleckstrin homology domain of the ceramide transport protein CERT.

C. Elwell, J. Engel, K. Hanada, 2018, Biochemical and biophysical research communications.

Trafficking Intracellular Growth and Chlamydia Family Tyrosine Kinases Regulate Species-Specific Interactions of Src

C. Elwell, J. Engel, A. Kierbel, 2012 .

Species-Specific Interactions of Src Family Tyrosine Kinases Regulate Chlamydia Intracellular Growth and Trafficking

C. Elwell, J. Engel, A. Kierbel, 2011, mBio.

Rho GTPase activity modulates Pseudomonas aeruginosa internalization by epithelial cells

J. Engel, K. Mostov, B. Kazmierczak, 2001, Cellular microbiology.

Pili Binding to Asialo-GM1 on Epithelial Cells Can Mediate Cytotoxicity or Bacterial Internalization byPseudomonas aeruginosa

J. Engel, K. Mostov, J. Comolli, 1999, Infection and Immunity.

The ADP Ribosyltransferase Domain of Pseudomonas aeruginosa ExoT Contributes to Its Biological Activities

J. Engel, S. Cordwell, J. Oza, 2004, Infection and Immunity.

A developmentally regulated chlamydial gene with apparent homology to eukaryotic histone H1.

J. Engel, D. Ganem, E. Perara, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Modulation of Cytosolic Ca2+ Concentration in Airway Epithelial Cells by Pseudomonas aeruginosa

J. Engel, T. Machen, Rebecca J. Lee, 2002, Infection and Immunity.

Modulation of Cytosolic Ca 2 (cid:1) Concentration in Airway Epithelial Cells by Pseudomonas aeruginosa

J. Engel, T. Machen, Rebecca J. Lee, 2002 .

Host cell‐derived sphingolipids are required for the intracellular growth of Chlamydia trachomatis

S. V. van IJzendoorn, J. Engel, K. Mostov, 2000, Cellular microbiology.

Chlamydial gene encoding a 70-kilodalton antigen in Escherichia coli: analysis of expression signals and identification of the gene product

J. Engel, D. Ganem, L. Sardinia, 1989, Journal of bacteriology.

Lipid acquisition by intracellular Chlamydiae

C. Elwell, J. Engel, 2012, Cellular microbiology.

Par3 integrates Tiam1 and phosphatidylinositol 3-kinase signaling to change apical membrane identity

J. Engel, K. Mostov, David M. Bryant, 2017, Molecular biology of the cell.

Fusion of Chlamydia trachomatis-Containing Inclusions Is Inhibited at Low Temperatures and Requires Bacterial Protein Synthesis

J. Engel, Eleanor Z. Kincaid, C. van Ooij, 1998, Infection and Immunity.

Developing Cyclic Peptomers as Broad-Spectrum Gram negative Bacterial Type III Secretion System Inhibitors

J. Engel, R. Lokey, Victoria Auerbuch, 2020, bioRxiv.

Azithromycin-induced block of elementary body formation in Chlamydia trachomatis

J. Engel, 1992, Antimicrobial Agents and Chemotherapy.

Pseudomonas aeruginosa Pili and Flagella Mediate Distinct Binding and Signaling Events at the Apical and Basolateral Surface of Airway Epithelium

J. Engel, I. Bucior, Julia F. Pielage, 2012, PLoS pathogens.

Pseudomonas aeruginosa mechanosensing controls cell polarity during twitching by activating two antagonistic response regulators

J. Engel, Y. Inclán, Alexandre Persat, 2022, bioRxiv.

Bacterial internalization is required to trigger NIK-dependent NF-κB activation in response to the bacterial type three secretion system

J. Engel, N. G. Herrera, Victoria Auerbuch, 2017, PloS one.

Evolutionary conservation in the untranslated regions of actin mRNAs: DNA sequence of a human beta-actin cDNA.

L. Kedes, P. Gunning, J. Engel, 1984, Nucleic acids research.

Isolation and characterization of full-length cDNA clones for human alpha-, beta-, and gamma-actin mRNAs: skeletal but not cytoplasmic actins have an amino-terminal cysteine that is subsequently removed

H. Blau, L. Kedes, P. Gunning, 1983, Molecular and cellular biology.

Chlamydia cell biology and pathogenesis

C. Elwell, J. Engel, Kathleen M. Mirrashidi, 2016, Nature Reviews Microbiology.

The Pseudomonas aeruginosa type III secreted toxin ExoT is necessary and sufficient to induce apoptosis in epithelial cells

J. Engel, S. Shafikhani, C. Morales, 2008, Cellular microbiology.

H. Blau, P. Gunning, H. Okayama, 1983, Molecular and cellular biology.

Drosophila melanogaster S2 cells: a model system to study Chlamydia interaction with host cells

C. Elwell, J. Engel, Joanne N. Engel, 2005, Cellular microbiology.

Chlamydia trachomatis Co-opts the FGF2 Signaling Pathway to Enhance Infection

C. Elwell, J. Engel, J. H. Kim, 2011, PLoS pathogens.

Global Mapping of the Inc-Human Interactome Reveals that Retromer Restricts Chlamydia Infection.

Gwendolyn M. Jang, N. Krogan, M. Shales, 2015, Cell host & microbe.

A mycobacterial virulence gene cluster extending RD1 is required for cytolysis, bacterial spreading and ESAT‐6 secretion

J. Engel, E. Brown, H. Morisaki, 2004, Molecular microbiology.

Isolation and characterization of human actin genes.

L. Kedes, P. Gunning, J. Engel, 1981, Proceedings of the National Academy of Sciences of the United States of America.

J. Engel, S. Fleiszig, K. Mostov, 1997 .

Chlamydial intracellular survival strategies.

R. Bastidas, R. Valdivia, C. Elwell, 2013, Cold Spring Harbor perspectives in medicine.

Chlamydia trachomatis Co-opts GBF1 and CERT to Acquire Host Sphingomyelin for Distinct Roles during Intracellular Development

C. Elwell, J. Engel, K. Hanada, 2011, PLoS pathogens.

Stage-specific regulation of protein phosphorylation in Leishmania major.

J. Engel, K. Dell, 1994, Molecular and biochemical parasitology.

Explorer Effector ExoU from the type III secretion system is an important modulator of gene expression in lung epithelial cells in response to Pseudomonas aeruginosa infection

D. Hume, J. Engel, B. Wainwright, 2017 .

Effector ExoU from the Type III Secretion System Is An Important Modulator of Gene Expression in Lung Epithelial Cells in Response to Pseudomonas aeruginosa Infection

D. Hume, J. Engel, B. Wainwright, 2003, Infection and Immunity.

Effector ExoU from the Type III Secretion System Is an Important Modulator of Gene Expression in Lung Epithelial Cells in Response to Pseudomonas aeruginosa Infection

D. Hume, J. Engel, B. Wainwright, 2003, Infection and Immunity.

Infection Pseudomonas aeruginosa Response to Expression in Lung Epithelial Cells in System Is an Important Modulator of Gene Effector ExoU from the Type III Secretion

D. Hume, J. Engel, B. Wainwright, 2003 .

Roles of type IV pili, flagellum-mediated motility and extracellular DNA in the formation of mature multicellular structures in Pseudomonas aeruginosa biofilms.

C. Whitchurch, J. Engel, T. Tolker-Nielsen, 2008, Environmental microbiology.

Spatiotemporal pharmacodynamics of meropenem- and tobramycin-treated Pseudomonas aeruginosa biofilms

A. Spormann, J. Engel, D. Verotta, 2017, The Journal of antimicrobial chemotherapy.

Correction: RNA Interference Screen Identifies Abl Kinase and PDGFR Signaling in Chlamydia trachomatis Entry

D. Kalman, C. Elwell, J. Engel, 2013, PLoS Pathogens.

RNAi Screen Reveals an Abl Kinase-Dependent Host Cell Pathway Involved in Pseudomonas aeruginosa Internalization

D. Kalman, J. Engel, Kimberly R. Powell, 2008, PLoS pathogens.

RNA Interference Screen Identifies Abl Kinase and PDGFR Signaling in Chlamydia trachomatis Entry

D. Kalman, C. Elwell, J. Engel, 2008, PLoS pathogens.

Use of a novel coinfection system reveals a role for Rac1, H-Ras, and CrkII phosphorylation in Helicobacter pylori-induced host cell actin cytoskeletal rearrangements.

J. Engel, S. Brandt, R. Hartig, 2007, FEMS immunology and medical microbiology.

The ubiquitin ligase Cbl-b limits Pseudomonas aeruginosa exotoxin T-mediated virulence.

J. Engel, P. Balachandran, L. Dragone, 2007, The Journal of clinical investigation.

Mechanotaxis directs Pseudomonas aeruginosa twitching motility

J. Engel, Alexandre Persat, Jose Negrete, 2021, Proceedings of the National Academy of Sciences.

Genetic Analysis of the Regulation of Type IV Pilus Function by the Chp Chemosensory System of Pseudomonas aeruginosa

J. West, J. Engel, Jacob J. Bertrand, 2009, Journal of bacteriology.

Cloning and characterization of the RNA polymerase alpha-subunit operon of Chlamydia trachomatis

M. Tan, J. Engel, D. Ganem, 1993, Journal of bacteriology.

Heat shock response of murine Chlamydia trachomatis

J. Pollack, J. Engel, D. Ganem, 1990, Journal of bacteriology.

Pseudomonas aeruginosa Gene Products PilT and PilU Are Required for Cytotoxicity In Vitro and Virulence in a Mouse Model of Acute Pneumonia

J. Mattick, C. Whitchurch, J. Engel, 1999, Infection and Immunity.

Pseudomonas aeruginosa Induces Type-III-Secretion-Mediated Apoptosis of Macrophages and Epithelial Cells

J. Engel, A. Hauser, 1999, Infection and Immunity.

Identification of Pseudomonas aeruginosa genes required for epithelial cell injury

J. Engel, K. Mostov, G. Apodaca, 1997, Molecular microbiology.

A polymerase chain reaction-based approach to cloning sigma factors from eubacteria and its application to the isolation of a sigma-70 homolog from Chlamydia trachomatis

J. Engel, D. Ganem, 1990, Journal of bacteriology.

Molecular Pathogenesis of Acute Pseudomonas Aeruginosa Infections

J. Engel, 2003 .

Pseudomonas aeruginosa type III-secreted toxin ExoT inhibits host-cell division by targeting cytokinesis at multiple steps

J. Engel, S. Shafikhani, Sasha H. Shafikhani, 2006, Proceedings of the National Academy of Sciences.

Enabling Genetic Analysis of Diverse Bacteria with Mobile-CRISPRi

John S. Hawkins, J. E. Peters, A. Grossman, 2018, Nature Microbiology.

Mobile-CRISPRi: Enabling Genetic Analysis of Diverse Bacteria

John S. Hawkins, J. E. Peters, A. Grossman, 2018, bioRxiv.

Characterization of a complex chemosensory signal transduction system which controls twitching motility in Pseudomonas aeruginosa

J. Mattick, A. Darzins, S. Beatson, 2004, Molecular microbiology.

Infection with Chlamydia trachomatis alters the tyrosine phosphorylation and/or localization of several host cell proteins including cortactin

J. Engel, S. Mutka, C. van Ooij, 1997, Infection and immunity.

The Pseudomonas aeruginosa Type III Translocon Is Required for Biofilm Formation at the Epithelial Barrier

J. Engel, T. Tolker-Nielsen, M. Givskov, 2014, PLoS pathogens.

Title Drosophila melanogaster S 2 cells : a model system to study Chlamydia interaction with host cells

C. Elwell, J. Engel, 2005 .

Tarp and Arp: How Chlamydia induces its own entry.

J. Engel, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Transcriptional organization and regulation of the dnaK and groE operons of Chlamydia trachomatis

M. Tan, J. Engel, B. Wong, 1996, Journal of bacteriology.

Characterization of the Chlamydia trachomatis vacuole and its interaction with the host endocytic pathway in HeLa cells

J. Engel, G. Apodaca, C. V. Ooij, 1997, Infection and immunity.

21 – Identification and Comparison of Putative Chlamydial Promoter Elements

J. Engel, D. Ganem, 1990 .

Phosphatidylinositol-3,4,5-trisphosphate regulates the formation of the basolateral plasma membrane in epithelial cells

J. Engel, Wei Yu, K. Mostov, 2006, Nature Cell Biology.

CbpA: a Polarly Localized Novel Cyclic AMP-Binding Protein in Pseudomonas aeruginosa

J. Engel, T. Endoh, 2009, Journal of bacteriology.

Azithromycin-Induced BlockofElementary Body Formation inChlamydia trachomatis

J. Engel, 1992 .

Pseudomonas aeruginosa exploits a PIP3-dependent pathway to transform apical into basolateral membrane

J. Engel, K. Mostov, Lilliana Radoshevich, 2007, The Journal of cell biology.

Trachomatis Rrna P1 Promoter. Transcription in Vitro from the Chlamydia Identification of Sequences Necessary For

M. Tan, J. Engel, J. B. M. Tan, 1996 .

Mutational Analysis of the Chlamydia trachomatis rRNA P1 Promoter Defines Four Regions Important for Transcription In Vitro

R. Gourse, M. Tan, J. Engel, 1998, Journal of bacteriology.

Targeting the Mucosal Barrier: How Pathogens Modulate the Cellular Polarity Network.

J. Engel, Travis R. Ruch, 2017, Cold Spring Harbor perspectives in biology.

Developing Cyclic Peptomers as Broad-Spectrum Type III Secretion System Inhibitors in Gram-Negative Bacteria

J. Engel, R. Lokey, Victoria Auerbuch, 2021, Antimicrobial Agents and Chemotherapy.

The phosphoinositol-3-kinase-protein kinase B/Akt pathway is critical for Pseudomonas aeruginosa strain PAK internalization.

J. Engel, K. Mostov, A. Gassama-Diagne, 2005, Molecular biology of the cell.

Assessing Pseudomonas virulence using host cells.

J. Engel, I. Bucior, Cindy S Tran, 2014, Methods in molecular biology.

Cloning and characterization of RNA polymerase core subunits of Chlamydia trachomatis by using the polymerase chain reaction

J. Pollack, J. Engel, D. Ganem, 1990, Journal of bacteriology.

A scaffold protein connects type IV pili with the Chp chemosensory system to mediate activation of virulence signaling in Pseudomonas aeruginosa

N. Krogan, J. Engel, Zemer Gitai, 2016, Molecular microbiology.

An essential, putative MEK kinase of Leishmania major.

J. Engel, S. Reed, P. G. Agron, 2005, Molecular and biochemical parasitology.

Endosulfatases SULF1 and SULF2 limit Chlamydia muridarum infection

T. Dierks, C. Elwell, J. Engel, 2013, Cellular microbiology.

Developing Cyclic Peptomers as Broad-Spectrum Gram-negative Bacterial Type III Secretion System Inhibitors.

J. Engel, R. Lokey, Victoria Auerbuch, 2021, Antimicrobial agents and chemotherapy.

Author response: Chlamydia interfere with an interaction between the mannose-6-phosphate receptor and sorting nexins to counteract host restriction

N. Krogan, Jeffrey R. Johnson, C. Elwell, 2017 .

Two antagonistic response regulators control Pseudomonas aeruginosa polarization during mechanotaxis

J. Engel, Alexandre Persat, H. Macmillan, 2023, The EMBO journal.

Chlamydial intracellular survival strategies.

R. Bastidas, R. Valdivia, C. Elwell, 2013, Cold Spring Harbor perspectives in medicine.

Identification of sequences necessary for transcription in vitro from the Chlamydia trachomatis rRNA P1 promoter

M. Tan, J. Engel, 1996, Journal of bacteriology.

Spatiotemporal pharmacodynamics of meropenem- and tobramycin-treated Pseudomonas aeruginosa biofilms

A. Spormann, J. Engel, D. Verotta, 2017, The Journal of antimicrobial chemotherapy.

In host evolution of beta lactam resistance during active treatment for Pseudomonas aeruginosa bacteremia

N. Neff, J. Derisi, J. Engel, 2023, Frontiers in cellular and infection microbiology.