S. Peukert

发表

New inhibitors of poly(ADP-ribose) polymerase (PARP)

S. Peukert, U. Schwahn, 2004 .

Blockers of the Kv1.5 channel for the treatment of atrial arrhythmias

S. Peukert, J. Brendel, 2002 .

Discovery of an Acrylic Acid Based Tetrahydroisoquinoline as an Orally Bioavailable Selective Estrogen Receptor Degrader for ERα+ Breast Cancer.

F. Lombardo, Alice T. Loo, L. Hamann, 2017, Journal of medicinal chemistry.

Small‐Molecule Inhibitors of the Hedgehog Signaling Pathway as Cancer Therapeutics

S. Peukert, K. Miller-Moslin, K. Miller‐Moslin, 2010, ChemMedChem.

Discovery of LSZ102, a Potent, Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen Receptor Positive Breast Cancer.

F. Lombardo, L. Hamann, T. Abrams, 2018, Journal of medicinal chemistry.

Blockers of the Kv1.5 channel for the treatment of atrial arrhythmias.

S. Peukert, J. Brendel, 2003, Current medicinal chemistry. Cardiovascular and hematological agents.

Discovery of NVP‐LEQ506, a Second‐Generation Inhibitor of Smoothened

John Green, J. Williams, B. Lagu, 2013, ChemMedChem.

1-amino-4-benzylphthalazines as orally bioavailable smoothened antagonists with antitumor activity.

J. Williams, S. Peukert, R. Guo, 2009, Journal of medicinal chemistry.

Identification and structure-activity relationships of ortho-biphenyl carboxamides as potent Smoothened antagonists inhibiting the Hedgehog signaling pathway.

S. Peukert, J. Kelleher, R. Jain, 2009, Bioorganic & medicinal chemistry letters.

Biophysical Investigation of the Mode of Inhibition of Tetramic Acids, the Allosteric Inhibitors of Undecaprenyl Pyrophosphate Synthase

S. Peukert, Lac V. Lee, R. Tommasi, 2010, Biochemistry.

Discovery of a Brain Penetrant ATP-competitive Inhibitor of the Mechanistic Target of Rapamycin (mTOR) for CNS disorders.

D. Curtis, F. Lombardo, Christopher J. Wilson, 2020, Journal of medicinal chemistry.

Identification, synthesis, and activity of novel blockers of the voltage-gated potassium channel Kv1.5.

H. Hemmerle, A. Brüggemann, B. Pirard, 2003, Journal of medicinal chemistry.

Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist.

M. Warmuth, J. Williams, S. Peukert, 2010, ACS medicinal chemistry letters.

Structure activity relationships of 4-hydroxy-2-pyridones: A novel class of antituberculosis agents.

Paul W Smith, S. Peukert, N. Ma, 2015, European journal of medicinal chemistry.

Diastereoselectivity in the SE2″ reaction of chiral pentadienylsilanes: a test for the relative importance of steric and electronic effects

A. K. Sarkar, I. Fleming, S. Peukert, 1996 .

Design and structure-activity relationships of potent and selective inhibitors of undecaprenyl pyrophosphate synthase (UPPS): tetramic, tetronic acids and dihydropyridin-2-ones.

Rui Zhang, S. Peukert, M. Sabio, 2008, Bioorganic & medicinal chemistry letters.

Enantioselective parallel synthesis using polymer-supported chiral Co(salen) complexes.

S. Peukert, E. Jacobsen, 1999, Organic letters.

Diastereoselectivity in the SE2′′ Reaction of Chiral Pentadienylsilanes: A Test for the Relative Importance of Steric and Electronic Effects.

A. K. Sarkar, I. Fleming, S. Peukert, 1996 .

A method for estimating the risk of drug-induced phototoxicity and its application to smoothened inhibitors

William Egan, W. Egan, B. Lagu, 2011 .

Interfering with Resistance to Smoothened Antagonists by Inhibition of the PI3K Pathway in Medulloblastoma

Jing Yuan, William R. Sellers, Christoph Lengauer, 2010, Science Translational Medicine.

Small‐Molecule Inhibitors of the Hedgehog Signaling Pathway as Cancer Therapeutics

S. Peukert, K. Miller-Moslin, K. Miller‐Moslin, 2010, ChemMedChem.

Chapter 16 Hedgehog Signaling Pathway Inhibitors as Cancer Therapeutics

S. Peukert, K. Miller-Moslin, K. Miller‐Moslin, 2009 .

Electrophysiological and antiarrhythmic effects of the novel IKur channel blockers, S9947 and S20951, on left vs. right pig atrium in vivo in comparison with the IKr blockers dofetilide, azimilide, d,l-sotalol and ibutilide

K. Knobloch, S. Peukert, A. Busch, 2002, Naunyn-Schmiedeberg's Archives of Pharmacology.

The frequency of occurrence of anti-cardiac receptor autoantibodies and their correlation with clinical manifestation in patients with hypertrophic cardiomyopathy.

R. Dietz, S. Peukert, A. Hempel, 1999, Autoimmunity.

ESR evidence for a heterolytic C,O-bond cleavage in models of 4′-DNA radicals

R. Batra, B. Giese, S. Peukert, 1997 .

Discovery of 2-Pyridylpyrimidines as the First Orally Bioavailable GPR39 Agonists.

A. Bose, S. Peukert, R. Jain, 2014, ACS medicinal chemistry letters.

Discovery of a brain-sparing GIRK1/4 inhibitor for pharmacological cardioversion of atrial fibrillation.

S. Peukert, Fupeng Ma, Yunshan Peng, 2023, Bioorganic & medicinal chemistry letters.

Molecular Basis for Kv1.5 Channel Block

M. Sanguinetti, B. Pirard, S. Peukert, 2004, Journal of Biological Chemistry.

The Pivaloylglycol Anchor Group: A New Platform for a Photolabile Linker in Solid-Phase Synthesis

B. Giese, S. Peukert, 1998 .

A New Platform for Designing Ligands for Asymmetric Induction in Allylic Alkylations

B. Trost, J. Ziller, S. Peukert, 1995 .

The Discovery of Kv1.5 Blockers as a Case Study for the Application of Virtual Screening Approaches

Bernard Pirard, Joachim Brendel, Stefan Peukert, 2005, J. Chem. Inf. Model..

Pharmacophore-based search, synthesis, and biological evaluation of anthranilic amides as novel blockers of the Kv1.5 channel.

Heinz-Werner Kleemann, Horst Hemmerle, Bernard Pirard, 2004, Bioorganic & medicinal chemistry letters.

The Discovery of Kv1.5 Blockers as a Case Study for the Application of Virtual Screening Approaches.

Bernard Pirard, Joachim Brendel, B. Pirard, 2005 .

Identification of Brain-Penetrant ATP-Competitive mTOR Inhibitors for CNS Syndromes.

D. Curtis, Christopher J. Wilson, P. Furet, 2023, Journal of Medicinal Chemistry.

Interfering with Resistance to Smoothened Antagonists by Inhibition of the PI3K Pathway in Medulloblastoma

Michael P. Morrissey, W. Sellers, J. Monahan, 2010, Science Translational Medicine.