J. Melchor

发表

Charge Alterations of E22 Enhance the Pathogenic Properties of the Amyloid β‐Protein

W. V. Van Nostrand, J. Melchor, L. Mcvoy, 2000 .

Fibrillar Amyloid β-Protein Mediates the Pathologic Accumulation of Its Secreted Precursor in Human Cerebrovascular Smooth Muscle Cells*

W. V. Van Nostrand, J. Melchor, 2000, The Journal of Biological Chemistry.

Pathologic Amyloid β‐Protein Cell Surface Fibril Assembly on Cultured Human Cerebrovascular Smooth Muscle Cells

W. V. Van Nostrand, J. Melchor, L. Ruffini, 1998 .

Evolutionary Dynamics of Non-Coding Regions in Pancreatic Ductal Adenocarcinoma

Johannes G. Reiter, N. Socci, S. Lowe, 2020 .

Localization of a Fibrillar Amyloid β-Protein Binding Domain on Its Precursor*

Judianne Davis, W. V. Van Nostrand, J. Melchor, 2002, The Journal of Biological Chemistry.

Pathogenic Effects of Cerebral Amyloid Angiopathy Mutations in the Amyloid β‐Protein Precursor

Judianne Davis, J. Melchor, G. Romanov, 2002, Annals of the New York Academy of Sciences.

Analysis of tau post-translational modifications in rTg4510 mice, a model of tau pathology

Lynn A. Hyde, J. Melchor, J. Hess, 2015, Molecular Neurodegeneration.

Pathogenic effects of D23N Iowa mutant amyloid beta -protein.

S. Greenberg, W. V. Van Nostrand, H. Cho, 2001, The Journal of biological chemistry.

Modulation of Sympathetic Activity by Tissue Plasminogen Activator Is Independent of Plasminogen and Urokinase

J. Melchor, S. Strickland, S. Vorlová, 2007, Journal of Pharmacology and Experimental Therapeutics.

The possible role of tissue-type plasminogen activator (tPA) and tPA blockers in the pathogenesis and treatment of Alzheimer’s disease

J. Melchor, S. Strickland, R. Pawlak, 2007, Journal of Molecular Neuroscience.

The tissue plasminogen activator-plasminogen proteolytic cascade accelerates amyloid-beta (Abeta) degradation and inhibits Abeta-induced neurodegeneration.

J. Melchor, S. Strickland, R. Pawlak, 2003, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Fibrillar amyloid beta-protein mediates the pathologic accumulation of its secreted precursor in human cerebrovascular smooth muscle cells.

W. V. Van Nostrand, J. Melchor, 2000, The Journal of biological chemistry.

Tissue plasminogen activator in central nervous system physiology and pathology

J. Melchor, S. Strickland, 2005, Thrombosis and Haemostasis.

Pathologic amyloid beta-protein cell surface fibril assembly on cultured human cerebrovascular smooth muscle cells.

W. V. Van Nostrand, J. Melchor, L. Ruffini, 1998, Journal of neurochemistry.

Unbiased in vivo preclinical evaluation of anticancer drugs identifies effective therapy for the treatment of pancreatic adenocarcinoma

C. Iacobuzio-Donahue, S. Leach, C. Haglund, 2020, Proceedings of the National Academy of Sciences.

Ethanol-withdrawal seizures are controlled by tissue plasminogen activator via modulation of NR2B-containing NMDA receptors.

Sidney Strickland, Tomasz Matys, Robert Pawlak, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Altered RNA Splicing by Mutant p53 Activates Oncogenic RAS Signaling in Pancreatic Cancer.

Sharon A. Lawrence, B. Taylor, S. Lowe, 2020, Cancer cell.

Evolutionary Origins of Recurrent Pancreatic Cancer

Johannes G. Reiter, Jeffrey M. Gerold, M. Nowak, 2019, bioRxiv.

PanIN neuroendocrine cells promote tumorigenesis via neuronal crosstalk.

S. Leach, D. Tuveson, P. Pasricha, 2017, Cancer research.

PanIN Neuroendocrine Cells Promote Tumorigenesis via Neuronal Cross-talk.

S. Leach, D. Tuveson, P. Pasricha, 2017, Cancer research.

Running title: PanIN neuroendocrine cells promote tumorigenesis Keywords: Pancreatic Ductal Adenocarcinoma (PDAC); Pancreatic Intraepithelial Neoplasia (PanIN); Tumor Microenvironment; Sensory Nerves and Axons; Substance P (SP); Neurokinin 1 Receptor (NK1-R); Chromogranin A (CgA); Endocrine and Neur

S. Leach, D. Tuveson, P. Pasricha, 2017 .

Subclonal somatic copy number alterations emerge and dominate in recurrent osteosarcoma

C. Iacobuzio-Donahue, E. Papaemmanuil, G. Gundem, 2023, bioRxiv.

Targeting eIF4A-Dependent Translation of KRAS Signaling Molecules

Stefan G. Stark, G. Rätsch, A. Viale, 2021, Cancer Research.

A unifying paradigm for transcriptional heterogeneity and squamous features in pancreatic ductal adenocarcinoma

L. Wood, R. Hruban, C. Iacobuzio-Donahue, 2020, Nature Cancer.

Pathogenic Effects of D23N Iowa Mutant Amyloid β-Protein*

S. Greenberg, W. V. Van Nostrand, J. Melchor, 2001, The Journal of Biological Chemistry.

Tissue plasminogen activator and plasminogen mediate stress-induced decline of neuronal and cognitive functions in the mouse hippocampus.

S. Chattarji, B. McEwen, J. Melchor, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Tissue plasminogen activator in the amygdala is critical for stress-induced anxiety-like behavior

B. McEwen, J. Melchor, S. Strickland, 2003, Nature Neuroscience.

Fibrin deposition accelerates neurovascular damage and neuroinflammation in mouse models of Alzheimer's disease.

J. Melchor, S. Strickland, J. Paul, 2007 .

The Tissue Plasminogen Activator-Plasminogen Proteolytic Cascade Accelerates Amyloid-β (Aβ) Degradation and Inhibits Aβ-Induced Neurodegeneration

J. Melchor, S. Strickland, R. Pawlak, 2003, The Journal of Neuroscience.

Analysis of tau post-translational modifications in rTg4510 mice, a model of tau pathology

Lynn A. Hyde, J. Melchor, J. Hess, 2015, Molecular Neurodegeneration.

MK-8719, a Novel and Selective O-GlcNAcase Inhibitor That Reduces the Formation of Pathological Tau and Ameliorates Neurodegeneration in a Mouse Model of Tauopathy

Lynn A. Hyde, E. Hostetler, J. Uslaner, 2020, The Journal of Pharmacology and Experimental Therapeutics.

Cerebrovascular Smooth Muscle Cell Surface Fibrillar Aβ: Alteration of the Proteolytic Environment in the Cerebral Vessel Wall

Judianne Davis, W. V. Van Nostrand, J. Melchor, 2000, Annals of the New York Academy of Sciences.

Genetic and clinical correlates of entosis in pancreatic ductal adenocarcinoma

C. Iacobuzio-Donahue, O. Basturk, A. Varghese, 2020, Modern Pathology.

Disruption of pathologic amyloid beta-protein fibril assembly on the surface of cultured human cerebrovascular smooth muscle cells.

W. V. Van Nostrand, J. Melchor, 2001, Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.

Charge alterations of E22 enhance the pathogenic properties of the amyloid-β protein

J. Melchor, L. Mcvoy, 2000, Neurobiology of Aging.

Localization of a fibrillar amyloid beta-protein binding domain on its precursor.

Judianne Davis, W. V. Van Nostrand, J. Melchor, 2002, The Journal of biological chemistry.

Fibrillar Amyloid b -Protein Mediates the Pathologic Accumulation of Its Secreted Precursor in Human Cerebrovascular Smooth Muscle Cells*

J. Melchor, W. E. Nostrand, 2000 .

Tissue plasminogen activator in central nervous system physiology and pathology

J. Melchor, S. Strickland, 2005, Thrombosis and Haemostasis.

Fibrillar amyloid beta-protein binds protease nexin-2/amyloid beta-protein precursor: stimulation of its inhibition of coagulation factor XIa.

W. V. Van Nostrand, J. Melchor, D. Keane, 2000, Biochemistry.