R. Shank

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Amyloid Peptide Aβ1‐42 Binds Selectively and with Picomolar Affinity to α7 Nicotinic Acetylcholine Receptors

Hoau Yan Wang, D. H. Lee, C. B. Davis, 2000 .

Amyloid peptide Abeta(1-42) binds selectively and with picomolar affinity to alpha7 nicotinic acetylcholine receptors.

C. B. Davis, R. Shank, H. Wang, 2000, Journal of neurochemistry.

beta-Amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology.

P. A. Peterson, M. D'Andrea, R. Shank, 2000, The Journal of biological chemistry.

Glutamate and GABA uptake by cerebellar granule and glial cell enriched populations

R. Shank, G. L. Campbell, G. Campbell, 1978, Brain Research.

Post mortem changes in the content and specific radioactivity of several amino acids in four areas of the rat brain.

R. Shank, M. H. Aprison, 1971, Journal of neurobiology.

New directions in anxiolytic drug research.

R. Shank, S. Nortey, A. Reitz, 1999, Progress in medicinal chemistry.

Characterization of a benzodiazepine receptor site with exceptionally high affinity for Ro 15-4513 in the rat CNS

R. Shank, A. Mehta, 1995, Brain Research.

Topiramate monotherapy in epilepsy and migraine prevention.

E. Ben-Menachem, S. Silberstein, F. Wiegand, 2005, Clinical therapeutics.

THE METABOLISM IN VIVO OF GLYCINE AND SERINE IN EIGHT AREAS OF THE RAT CENTRAL NERVOUS SYSTEM 1

R. Shank, M. H. Aprison, 1970, Journal of neurochemistry.

Anticonvulsant activity of topiramate and phenytoin in a rat model of ischemia-induced epilepsy.

H. Edmonds, R. Shank, Y. D. Jiang, 1996, Life sciences.

A comparison of the concentration of glycine, a transmitter suspect, in different areas of the brain and spinal cord in seven different vertebrates.

R. A. Davidoff, R. Shank, M. H. Aprison, 1969, Comparative biochemistry and physiology.

Glutamine and 2-oxoglutarate as metabolic precursors of the transmitter pools of glutamate and GABA: Correlation of regional uptake by rat brain synaptosomes

R. Shank, W. J. Baldy, C. W. Ash, 1989, Neurochemical Research.

Analysis of [1-13C]D-glucose metabolism in cultured astrocytes and neurons using nuclear magnetic resonance spectroscopy.

R. Shank, G. Leo, B. Driscoll, 1993, Developmental neuroscience.

Synthesis and Structure—Activity Relationship of Novel Pyridyl Ethers for the Nicotinic Acetylcholine Receptor.

C. B. Davis, R. Shank, R. Rivero, 2000 .

Pyrroloisoquinoline antidepressants. 2. In-depth exploration of structure-activity relationships [Erratum to document cited in CA107(17):154217r]

R. Shank, S. Nortey, D. McComsey, 1988 .

Topiramate as a neuroprotectant in a rat model of global ischemia-induced neurodegeneration.

H. Edmonds, R. Shank, Y. D. Jiang, 2001, Life sciences.

Topiramate promotes neurite outgrowth and recovery of function after nerve injury

C. Plata-salamán, R. Shank, Boyu Zhao, 2001, Neuroreport.

Inhibition of carbonic anhydrase-II by sulfamate and sulfamide groups: an investigation involving direct thermodynamic binding measurements.

R. Shank, A. Klinger, D. McComsey, 2006, Journal of medicinal chemistry.

2,3-Dihydro-dithiin and -dithiepine-1,1,4,4-tetroxides: small molecule non-peptide antagonists of the human galanin hGAL-1 receptor.

Hoau Yan Wang, D. H. Lee, C. B. Davis, 2000, Bioorganic & medicinal chemistry.

Carbonic anhydrase inhibition. Insight into the characteristics of zonisamide, topiramate, and the sulfamide cognate of topiramate

R. Shank, B. Maryanoff, V. Smith-Swintosky, 2008 .

Examination of Two Independent Kinetic Assays for Determining the Inhibition of Carbonic Anhydrases I and II: Structure–Activity Comparison of Sulfamates and Sulfamides

R. Shank, D. McComsey, B. Maryanoff, 2006, Chemical biology & drug design.

Present status and significance of the glutamine cycle in neural tissues.

R. Shank, M. H. Aprison, 1981, Life sciences.

2-Oxoglutarate Transport: Regulating Glutamate and Intermediates in Neurons* A Potential Mechanism for Tricarboxylic Acid Cycle

R. Shank, D. J. Bennett, 1993 .

The Multiple Roles of Glutamate and Aspartate in Neural Tissues

R. Shank, L. T. Graham, 1978 .

Orally active benzamide antipsychotic agents with affinity for dopamine D2, serotonin 5-HT1A, and adrenergic alpha1 receptors.

M. Renzi, C. B. Davis, R. Shank, 1998, Journal of medicinal chemistry.

2-Oxoglutarate transport: A protential mechanism for regulating glutamate and tricarboxylic acid cycle intermediates in neurons

R. Shank, D. J. Bennett, 1993, Neurochemical Research.

Complementary and synergistic antinociceptive interaction between the enantiomers of tramadol.

R. Shank, R. Raffa, E. Friderichs, 1993, The Journal of pharmacology and experimental therapeutics.

Opioid and nonopioid components independently contribute to the mechanism of action of tramadol, an 'atypical' opioid analgesic.

R. Shank, R. Raffa, R P Shank, 1992, The Journal of pharmacology and experimental therapeutics.

Serotonin and norepinephrine uptake inhibiting activity of centrally acting analgesics: structural determinants and role in antinociception.

R. Shank, R. Raffa, J. Schupsky, 1995, The Journal of pharmacology and experimental therapeutics.

Bicuculline and picrotoxin as antagonists of gamma-aminobutyrate and neuromuscular inhibition in the lobster.

A. R. Freeman, R. Shank, L. T. Graham, 1974, Brain research.

Plasma and whole blood pharmacokinetics of topiramate: the role of carbonic anhydrase

M. Bialer, R. Shank, A. Streeter, 2005, Epilepsy Research.

Pyrroloisoquinoline antidepressants. 3. A focus on serotonin.

R. Shank, S. Nortey, D. McComsey, 1990, Journal of medicinal chemistry.

Pyrroloisoquinoline antidepressants. 2. In-depth exploration of structure-activity relationships.

R. Shank, S. Nortey, D. McComsey, 1987, Journal of medicinal chemistry.

Pyrroloisoquinoline antidepressants. Potent, enantioselective inhibition of tetrabenazine-induced ptosis and neuronal uptake of norepinephrine, dopamine, and serotonin.

R. Shank, D. McComsey, B. Maryanoff, 1984, Journal of medicinal chemistry.

Potential anxiolytic agents. 2. Improvement of oral efficacy for the pyrido[1,2-a]benzimidazole (PBI) class of GABA-A receptor modulators

R. Shank, D. McComsey, B. Maryanoff, 1996 .

Potential anxiolytic agents. 3. Novel A-ring modified pyrido[1,2-a]benzimidazoles.

J J McNally, R. Shank, S. Nortey, 1999, Bioorganic & medicinal chemistry letters.

Topiramate as an Inhibitor of Carbonic Anhydrase Isoenzymes

R. Shank, S. Dodgson, B. Maryanoff, 2000, Epilepsia.

An Overview of the Preclinical Aspects of Topiramate: Pharmacology, Pharmacokinetics, and Mechanism of Action

R. Shank, B. Maryanoff, J. F. Gardocki, 2000, Epilepsia.

Topiramate modulation of kainate‐induced calcium currents is inversely related to channel phosphorylation level

E. Ben-Menachem, E. Hansson, L. Rönnbäck, 2003, Journal of neurochemistry.

Antinociceptive action of McN-5195 in rodents: a structurally novel (indolizine) analgesic with a nonopioid mechanism of action.

R. Shank, R. Raffa, J. Carson, 1990, The Journal of pharmacology and experimental therapeutics.

Potential anxiolytic agents. Pyrido[1,2-a]benzimidazoles: a new structural class of ligands for the benzodiazepine binding site on GABA-A receptors.

R. Shank, S. Nortey, A. Reitz, 1995, Journal of medicinal chemistry.

Structure-activity studies on anticonvulsant sugar sulfamates related to topiramate. Enhanced potency with cyclic sulfate derivatives.

R. Shank, S. Nortey, B. Maryanoff, 1998, Journal of medicinal chemistry.

Topiramate: Preclinical Evaluation of a Structurally Novel Anticonvulsant

C. B. Davis, R. Shank, S. Nortey, 1994, Epilepsia.

Anticonvulsant O-alkyl sulfamates. 2,3:4,5-Bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate and related compounds.

R. Shank, S. Nortey, B. Maryanoff, 1987, Journal of medicinal chemistry.

Adenosine Transport by Rat and Guinea Pig Synaptosomes: Basis for Differential Sensitivity to Transport Inhibitors

R. Shank, W. J. Baldy, 1990, Journal of neurochemistry.

β-Amyloid1–42 Binds to α7 Nicotinic Acetylcholine Receptor with High Affinity

P. A. Peterson, M. D'Andrea, Hoau Yan Wang, 2000, The Journal of Biological Chemistry.

Glutamate Uptake by the Isolated Toad Brain

R. Shank, C. Baxter, J. T. Whiten, 1973, Science.

DISTRIBUTION OF SOME SYNAPTIC TRANSMITTER SUSPECTS IN CAT SPINAL CORD: GLUTAMIC ACID, ASPARTIC ACID, γ‐AMINOBUTYRIC ACID, GLYCINE, AND GLUTAMINE *

R. Werman, R. Shank, M. H. Aprison, 1967, Journal of neurochemistry.

Etoperidone, trazodone and MCPP: in vitro and in vivo identification of serotonin 5-HT1A (antagonistic) activity

R. Shank, R. Raffa, J. L. Vaught, 2005, Psychopharmacology.

METABOLISM OF GLUCOSE, AMINO ACIDS, AND SOME RELATED METABOLITES IN THE BRAIN OF TOADS (BUFO BOREAS) ADAPTED TO FRESH WATER OR HYPEROSMOTIC ENVIRONMENTS

R. Shank, C. Baxter, 1973, Journal of neurochemistry.

Synthesis and structure-activity relationship of novel pyridyl ethers for the nicotinic acetylcholine receptor.

C. B. Davis, R. Shank, R. Rivero, 2000, Bioorganic & medicinal chemistry letters.

Action of aspartate at lobster excitatory neuromuscular junctions

A. R. Freeman, R. Shank, M. B. Wang, 1977, Brain Research.

Levels of free amino acids in excitatory, inhibitory and sensory axons of the walking limbs of the lobster.

A. R. Freeman, W. Mcbride, R. Shank, 1974, Life sciences.

Ornithine as a precursor of glutamate and GABA: Uptake and metabolism by neuronal and glial enriched cellular material

R. Shank, Graham LeM. Campbell, 1983, Journal of neuroscience research.

Ion Dependence of Neurotransmitter Uptake: Inhibitory Effects of Ion Substitutes

R. Shank, C. Schneider, Joseph J. Tighe, 1987, Journal of neurochemistry.

α‐Ketoglutarate and Malate Uptake and Metabolism by Synaptosomes: Further Evidence for an Astrocyte‐to‐Neuron Metabolic Shuttle

R. Shank, G. L. Campbell, 1984, Journal of neurochemistry.

Avid Na+-dependent, high-affinity uptake of alpha-ketoglutarate by nerve terminal enriched material from mouse cerebellum.

R. Shank, G. Campbell, 1981, Life sciences.

GLUTAMINE UPTAKE AND METABOLISM BY THE ISOLATED TOAD BRAIN: EVIDENCE PERTAINING TO ITS PROPOSED ROLE AS A TRANSMITTER PRECURSOR

R. Shank, M. H. Aprison, M. H. Aprison, 1977, Journal of neurochemistry.

Comparison of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-II by using topiramate as a structural platform.

R. Shank, D. McComsey, B. Maryanoff, 2005, Journal of medicinal chemistry.

Galanin inhibits acetylcholine release from rat cerebral cortex via a pertussis toxin-sensitive Giprotein

R. Shank, H. Wang, D. H. Lee, 1999, Neuropeptides.

Pyruvate car☐ylase: an astrocyte-specific enzyme implicated in the replenishment of amino acid neurotransmitter pools

R. Shank, S. Freytag, Richard P. Shank, 1985, Brain Research.

Adenosine 5′-monophosphate transport across the membrane of synaptosomes and myelin

R. Shank, 1992, Neurochemical Research.

Ion and Temperature Effects on the Binding of γ‐Aminobutyrate to Its Receptors and the High‐Affinity Transport System

R. Shank, R P Shank, W J Baldy, 1990, Journal of neurochemistry.

Glutamine and alpha-ketoglutarate uptake and metabolism by nerve terminal enriched material from mouse cerebellum

R. Shank, G. Campbell, 1982, Neurochemical Research.

Amino acid uptake, content, and metabolism by neuronal and glial enriched cellular fractions from mouse cerebellum

R. Shank, G. Campbell, 1984, The Journal of neuroscience : the official journal of the Society for Neuroscience.

UPTAKE AND METABOLISM OF GLUTAMATE BY ISOLATED TOAD BRAINS CONTAINING DIFFERENT LEVELS OF ENDOGENOUS AMINO ACIDS

R. Shank, C. Baxter, 1975, Journal of neurochemistry.

Viability of some metabolic processes in the isolated toad brain adapted to two osmotic environments.

R. Shank, C. Baxter, J. T. Whiten, 1975, Journal of neurobiology.

Method for multiple analyses of concentration and specific radioactivity of individual amino acids in nervous tissue extracts.

R. Shank, M. H. Aprison, 1970, Analytical biochemistry.

Metabolic Precursors of the Transmitter Pools of Glutamate and Aspartate

R. Shank, G. Campbell, 1986 .

Glutamine, Glutamate, and Other Possible Regulators of α‐Ketoglutarate and Malate Uptake by Synaptic Terminals

R. Shank, Graham Campbell, 1984, Journal of neurochemistry.

Neurochemical Evidence for Glycine as a Transmitter and a Model for Its Intrasynaptosomal Compartmentation

W. Mcbride, R. Shank, M. H. Aprison, 1975 .

Is Glycine a Neurotransmitter ?: Association of Glycine with Spinal Interneurones

R. A. Davidoff, R. Werman, R. Shank, 1967, Nature.

In vivo microdialysis and liquid chromatography/thermospray mass spectrometry of the novel anticonvulsant 2,3:4,5-bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate (topiramate) in rat brain fluid.

R. Shank, G. Caldwell, J. Masucci, 1998, Journal of mass spectrometry : JMS.

Molecular Pharmacodynamics, Clinical Therapeutics, and Pharmacokinetics of Topiramate

R. Shank, B. Maryanoff, 2008, CNS neuroscience & therapeutics.

Anticonvulsant O-Alkyl Sulfamates. 2,3:4,5-Bis-O-(1-methylethylidene)- β-D-fructopyranose Sulfamate (I) and Related Compounds.

R. Shank, S. Nortey, B. Maryanoff, 1987 .

5-Ethoxymethyl-7-fluoro-3-oxo-1,2,3,5-tetrahydrobenzo[4,5]imidazo[1,2a]pyridine-4-N- (2-fluorophenyl)carboxamide (RWJ-51204), a New Nonbenzodiazepine Anxiolytic

R. Shank, A. Reitz, A. R. Carter, 2002, Journal of Pharmacology and Experimental Therapeutics.

[3H][D-Ala2,NMePhe4,Gly-ol5]-enkephalin (mu-opioid) binding in beige-J mice

R. Shank, R. Raffa, J. Mathiasen, 1988, Peptides.

Block of conditioned avoidance responding in the rat by substituted phenylpiperazines.

R. Shank, G. Martin, J. Mathiasen, 1988, European journal of pharmacology.

Cerebral Metabolic Compartmentation as Revealed by Nuclear Magnetic Resonance Analysis of D‐[1‐13C]Glucose Metabolism

H. R. Zielke, R. Shank, G. Leo, 1993, Journal of neurochemistry.

Activity of aromatic substituted phenylpiperazines lacking affinity for dopamine binding sites in a preclinical test of antipsychotic efficacy.

C. B. Davis, R. Shank, G. Martin, 1989, Journal of medicinal chemistry.

Azepinoindole derivatives with high affinity for brain dopamine and serotonin receptors.

R. Shank, D. McComsey, B. Maryanoff, 1998, Bioorganic & medicinal chemistry letters.

Preclinical evaluation of McN-5707 as a potential antidepressant.

R. Shank, D. McComsey, B. Maryanoff, 1987, The Journal of pharmacology and experimental therapeutics.

CHANGES IN AMINO ACID CONCENTRATIONS ASSOCIATED WITH LOSS OF SPINAL INTERNEURONS *

R. A. Davidoff, R. Werman, R. Shank, 1967, Journal of neurochemistry.

Carbonic anhydrase inhibition. Insight into the characteristics of zonisamide, topiramate, and the sulfamide cognate of topiramate.

R. Shank, B. Maryanoff, V. Smith-Swintosky, 2008, Journal of Enzyme Inhibition and Medicinal Chemistry.

McN-5652: a highly potent inhibitor of serotonin uptake.

R. Shank, D. McComsey, B. Maryanoff, 1988, The Journal of pharmacology and experimental therapeutics.

Cooperative interaction of glutamate and aspartate with receptors in the neuromuscular excitatory membrane in walking limbs of the lobster.

A. R. Freeman, R. Shank, 1975, Journal of neurobiology.

Agonistic and antagonistic activity of glutamate analogs on neuromuscular excitation in the walking limbs of lobsters.

A. R. Freeman, R. Shank, 1976, Journal of neurobiology.

A New Arylpiperazine Antipsychotic (IV) with High D2/D3/5-HT1A/α 1A-Adrenergic Affinity and a Low Potential for Extrapyramidal Effects.

M. Renzi, R. Shank, A. Reitz, 1994 .

A new arylpiperazine antipsychotic with high D2/D3/5-HT1A/alpha 1A-adrenergic affinity and a low potential for extrapyramidal effects.

M. Renzi, R. Shank, A. Reitz, 1994, Journal of medicinal chemistry.

Effects of Topiramate on Kainate‐ and Domoate‐Activated [14C]Guanidinium Ion Flux Through GluR6 Channels in Transfected BHK Cells Using Cytostar‐T Scintillating Microplates

R. Shank, J. Egebjerg, F. Poulsen, 2000, Epilepsia.

gamma-Aminobutyrate-A receptor modulation by 3-aryl-1-(arylsulfonyl)- 1,4,5,6-tetrahydropyridazines.

R. Shank, B. Dubinsky, P. Rybczynski, 1999, Journal of medicinal chemistry.

Tryptamine enhancement of neurotransmitter release under conditions that normally depress calcium influx

A. R. Freeman, R. Shank, R. Friedman, 1986, Brain Research.

Association of glycine with spinal interneurones.

R. A. Davidoff, R. Werman, R. Shank, 1967, Nature.

Kinetics of 2-oxoglutarate uptake by synaptosomes from bovine and rat retina and cerebral cortex and regulation by glutamate and glutamine.

R. Shank, J. Lehmann, D. Kapkov, 1993, Developmental neuroscience.

EFFECT OF TETANUS TOXIN ON THE CONTENT OF GLYCINE, GAMMA‐AMINOBUTYRIC ACID, GLUTAMATE, GLUTAMINE AND ASPARTATE IN THE RAT SPINAL CORD 1 2

R. Shank, A. A. Fedinec, 1971, Journal of neurochemistry.

Glutamate and aspartate as mediators of neuromuscular excitation in the lobster.

A. R. Freeman, W. Mcbride, R. Shank, 1975, Comparative biochemistry and physiology. C: Comparative pharmacology.

The Novel Anticonvulsant Topiramate is Antiallodynic in a Rat Model of Neuropathic Pain

R. Shank, K. Wild, A. Shadiack, 1999 .

The distribution of glycine, a neurotransmitter suspect in the central nervous system of several vertebrate species

R. A. Davidoff, R. Werman, R. Shank, 1968 .

The effects of tryptamine on transmitter release at a lobster neuromuscular junction

A. R. Freeman, R. Shank, R. Friedman, 1981, Brain Research.

1,3-Di(2-[5-3H]tolyl)guanidine labels more than one site in rat forebrain.

R. Shank, E. Codd, 1992, European journal of pharmacology.

γ‐Aminobutyric Acid Formation from Glucose: Metabolic Pathway

R. Shank, W. Nicklas, 1990 .