D. Shima

发表

An NSF function distinct from ATPase-dependent SNARE disassembly is essential for Golgi membrane fusion

R. Newman, P. Freemont, G. Warren, 1999, Nature Cell Biology.

VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia

K. Alitalo, C. Betsholtz, H. Gerhardt, 2003, The Journal of cell biology.

Pegaptanib, a targeted anti-VEGF aptamer for ocular vascular disease

D. Guyer, D. Shima, E. Cunningham, 2006, Nature Reviews Drug Discovery.

Forkhead box N4 (Foxn4) activates Dll4-Notch signaling to suppress photoreceptor cell fates of early retinal progenitors

D. Shima, K. Hozumi, Min Zou, 2012, Proceedings of the National Academy of Sciences.

Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis.

Holger Gerhardt, Christiana Ruhrberg, Sofia Ioannidou, 2002, Genes & development.

Hypoxic induction of endothelial cell growth factors in retinal cells: identification and characterization of vascular endothelial growth factor (VEGF) as the mitogen.

J. Folkman, D. Shima, A. Adamis, 1995, Molecular medicine.

Brief Definitive Report 483 VEGF 164-mediated Inflammation Is Required for Pathological , but Not Physiological , Ischemia-induced Retinal Neovascularization

Joan W. Miller, E. Gragoudas, J. Ambati, 2017 .

Synergistic roles for Pim-1 and c-Myc in STAT3-mediated cell cycle progression and antiapoptosis.

T. Hirano, D. Shima, T. Shirogane, 1999, Immunity.

Targeted deletion of p97 (VCP/CDC48) in mouse results in early embryonic lethality.

G. Warren, D. Shima, I. Rosewell, 2007, Biochemical and biophysical research communications.

Sequential SNARE disassembly and GATE-16–GOS-28 complex assembly mediated by distinct NSF activities drives Golgi membrane fusion

R. Newman, G. Warren, J. Shorter, 2002, The Journal of cell biology.

An in vitro assay reveals a role for the diaphragm protein PV-1 in endothelial fenestra morphogenesis

D. Shima, K. Deinhardt, Eunice Cheung, 2006, Proceedings of the National Academy of Sciences.

VE‐PTP and VE‐cadherin ectodomains interact to facilitate regulation of phosphorylation and cell contacts

D. Shima, D. Vestweber, M. Golding, 2002, The EMBO journal.

RGS5 expression is a quantitative measure of pericyte coverage of blood vessels

D. Shima, T. Mitchell, Y. Ng, 2007, Angiogenesis.

Synergies of VEGF inhibition and photodynamic therapy in the treatment of age-related macular degeneration.

R. Gurny, C. Mailhos, D. Shima, 2007, Investigative ophthalmology & visual science.

Assessing a novel depot delivery strategy for noninvasive administration of VEGF/PDGF RTK inhibitors for ocular neovascular disease.

P. Coffey, P. Adamson, D. Shima, 2013, Investigative ophthalmology & visual science.

An isoform of the Golgi t-SNARE, syntaxin 5, with an endoplasmic reticulum retrieval signal.

B. Sönnichsen, G. Warren, D. Shima, 1997, Molecular biology of the cell.

Up-regulation of vascular endothelial growth factor production by iron chelators.

E. Voest, D. Shima, L. Beerepoot, 1996, Cancer research.

Delivery of anti-angiogenic molecular therapies for retinal disease.

D. Shima, J. Bainbridge, O. A. Anderson, 2010, Drug discovery today.

VE‐PTP and VE‐cadherin ectodomains interact to facilitate regulation of phosphorylation and cell contacts

D. Shima, D. Vestweber, M. Golding, 2013 .

Differential Apicobasal VEGF Signaling at Vascular Blood-Neural Barriers

J. Greenwood, D. Shima, C. Futter, 2014, Developmental cell.

Dll4 Suppresses Transcytosis for Arterial Blood-Retinal Barrier Homeostasis

Akiyoshi Uemura, Pilhan Kim, Y. S. Ju, 2020, Circulation research.

Macrophages fine-tune pupil shape during development.

D. Shima, Y. Kubota, T. Miyamoto, 2020, Developmental biology.

Novel CCR3 Antagonists Are Effective Mono- and Combination Inhibitors of Choroidal Neovascular Growth and Vascular Permeability.

P. Adamson, D. Shima, J. Bainbridge, 2015, The American journal of pathology.

Mutations in Dynein Link Motor Neuron Degeneration to Defects in Retrograde Transport

Yasushi Hiraoka, Christiana Ruhrberg, Holger Hummerich, 2003, Science.

Non-Occlusive Retinal Vascular Inflammation and Role of Red Blood Cell Deformability in Birdshot Chorioretinopathy

Thomas J. Smart, R. Agrawal, D. Shima, 2018, Ocular immunology and inflammation.

Alterations in gene expression associated with changes in the state of endothelial differentiation.

D. Shima, P. D’Amore, K. B. Saunders, 1995, Differentiation; research in biological diversity.

INHIBITION OF VEGF PREVENTS OCULAR NEOVASCULARIZATION IN A MONKEY MODEL

J. Folkman, D. Shima, M. Tolentino, 1995 .

Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188

Willem Flameng, Ingeborg Stalmans, Lieve Moons, 1999, Nature Medicine.

PKCα regulates β1 integrin‐dependent cell motility through association and control of integrin traffic

P. Bastiaens, P. Parker, M. Humphries, 1999 .

BTBR ob/ob mouse model of type 2 diabetes exhibits early loss of retinal function and retinal inflammation followed by late vascular changes

Vivian K. Lee, D. Shima, Peter J Gardner, 2018, Diabetologia.

VEGF164-mediated Inflammation Is Required for Pathological, but Not Physiological, Ischemia-induced Retinal Neovascularization

Joan W. Miller, E. Gragoudas, J. Ambati, 2003, The Journal of experimental medicine.

Vascular endothelial growth factor-A is a survival factor for retinal neurons and a critical neuroprotectant during the adaptive response to ischemic injury.

David T. Shima, John Bradley, D. Shima, 2007, The American journal of pathology.

VEGF164(165) as the pathological isoform: differential leukocyte and endothelial responses through VEGFR1 and VEGFR2.

Susumu Ishida, David T. Shima, Yuichi Kaji, 2004, Investigative ophthalmology & visual science.

Synthesis and secretion of vascular permeability factor/vascular endothelial growth factor by human retinal pigment epithelial cells.

J. Folkman, D. Shima, B. Berse, 1993, Biochemical and biophysical research communications.

Simultaneous but not prior inhibition of VEGF165 enhances the efficacy of photodynamic therapy in multiple models of ocular neovascularization.

C. Mailhos, D. Shima, P. Calias, 2008, Investigative ophthalmology & visual science.

A therapeutic aptamer inhibits angiogenesis by specifically targeting the heparin binding domain of VEGF165.

A. Pardi, F. Jucker, D. Shima, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Do Anti-Angiogenic VEGF (VEGFxxxb) Isoforms Exist? A Cautionary Tale

C. Kanthou, D. Shima, G. Tozer, 2012, PloS one.

the facial nerve ofand cooperates with Sema 3 A to pattern distinct compartments Vascular endothelial growth factor controls neuronal migration Material

A. Kolodkin, D. Ginty, D. Shima, 2011 .

The heparin-binding domain confers diverse functions of VEGF-A in development and disease: a structure-function study.

D. Shima, Y. Ng, D. Krilleke, 2009, Biochemical Society transactions.

Blood vessel maturation and response to vascular-disrupting therapy in single vascular endothelial growth factor-A isoform-producing tumors.

Christiana Ruhrberg, Chryso Kanthou, Constantino C Reyes-Aldasoro, 2008, Cancer research.

Molecular Mapping and Functional Characterization of the VEGF164 Heparin-binding Domain*

D. Shima, Indrajit Giri, Yin-Shan Ng, 2007, Journal of Biological Chemistry.

Proceedings of the Third International Symposium on Retinopathy of Prematurity: an update on ROP from the lab to the nursery (November 2003, Anaheim, California).

Bradley T. Smith, Lois E. H. Smith, W. Hauswirth, 2006, Molecular vision.

VEGF function in vascular pathogenesis.

D. Shima, Y. Ng, D. Krilleke, 2006, Experimental cell research.

Vascular endothelial growth factor controls neuronal migration and cooperates with Sema3A to pattern distinct compartments of the facial nerve.

A. Kolodkin, D. Ginty, D. Shima, 2004, Genes & development.

Vascular developmental biology: getting nervous.

C. Mailhos, D. Shima, 2000, Current opinion in genetics & development.

The Mouse Gene for Vascular Endothelial Growth Factor

D. Shima, A. Adamis, U. Deutsch, 1996, The Journal of Biological Chemistry.

Delta-like 4 is indispensable in thymic environment specific for T cell development

C. Mailhos, D. Shima, G. Holländer, 2008, The Journal of experimental medicine.

Neuropilin‐1 is required for endothelial tip cell guidance in the developing central nervous system

Holger Gerhardt, Christiana Ruhrberg, C. Betsholtz, 2004, Developmental dynamics : an official publication of the American Association of Anatomists.

Sox7 promotes high-grade glioma by increasing VEGFR2-mediated vascular abnormality

Hyung-Seok Kim, D. Shima, G. Koh, 2018, The Journal of experimental medicine.

Inhibition of platelet-derived growth factor B signaling enhances the efficacy of anti-vascular endothelial growth factor therapy in multiple models of ocular neovascularization.

C. Mailhos, D. Shima, A. Adamis, 2006, The American journal of pathology.

THE ROLE OF VASCULAR ENDOTHELIAL GROWTH FACTOR IN OCULAR HEALTH AND DISEASE

D. Shima, A. Adamis, 2005, Retina.

Tumor angiogenesis: A physiological process or genetically determined?

D. Shima, P. D’Amore, 1996, Cancer and Metastasis Reviews.

Inhibition of vascular endothelial growth factor prevents retinal ischemia-associated iris neovascularization in a nonhuman primate.

E S Gragoudas, Joan W. Miller, E. Gragoudas, 1996, Archives of ophthalmology.

The Mouse p97 (CDC48) Gene

G. Stamp, G. Warren, D. Shima, 1999, The Journal of Biological Chemistry.

Vascular endothelial growth factor/vascular permeability factor is temporally and spatially correlated with ocular angiogenesis in a primate model.

Joan W. Miller, J. Folkman, H. Dvorak, 1994, The American journal of pathology.

Hypoxic induction of vascular endothelial growth factor (VEGF) in human epithelial cells is mediated by increases in mRNA stability

D. Shima, U. Deutsch, P. D’Amore, 1995, FEBS letters.

Hypoxic Induction of Endothelial Cell Growth Factors in Retinal Cells: Identification and Characterization of Vascular Endothelial Growth Factor (VEGF) as the Mitogen

J. Folkman, D. Shima, A. Adamis, 1995 .

Partitioning of the Golgi Apparatus during Mitosis in Living HeLa Cells

R. Pepperkok, K. Haldar, G. Warren, 1997, The Journal of cell biology.

Erythropoietin promotes survival of retinal ganglion cells in DBA/2J glaucoma mice.

John Bradley, D. Shima, A. Adamis, 2007, Investigative ophthalmology & visual science.

Assessment of red blood cell deformability in type 2 diabetes mellitus and diabetic retinopathy by dual optical tweezers stretching technique

Thomas J. Smart, R. Agrawal, D. Shima, 2016, Scientific Reports.

Red blood cells in retinal vascular disorders.

R. Agrawal, J. Chhablani, D. Shima, 2016, Blood cells, molecules & diseases.

An Ordered Inheritance Strategy for the Golgi Apparatus: Visualization of Mitotic Disassembly Reveals a Role for the Mitotic Spindle

R. Pepperkok, G. Warren, D. Shima, 1998, The Journal of cell biology.

Cloning and mRNA expression of vascular endothelial growth factor in ischemic retinas of Macaca fascicularis.

Joan W. Miller, D. Shima, A. Adamis, 1996, Investigative ophthalmology & visual science.

A Na,K-ATPase–Fodrin–Actin Membrane Cytoskeleton Complex is Required for Endothelial Fenestra Biogenesis

Peter M. G. Munro, H. Vihinen, E. Jokitalo, 2020, Cells.

Segregation of COPI-rich and anterograde-cargo-rich domains in endoplasmic-reticulum-to-Golgi transport complexes

R. Pepperkok, D. Shima, T. Kreis, 1999, Current Biology.

Centrosome disorganization in fibroblast cultures derived from R6/2 Huntington's disease (HD) transgenic mice and HD patients.

E. Wanker, G. Bates, D. Shima, 2001, Human molecular genetics.

A2E Induces IL-1ß Production in Retinal Pigment Epithelial Cells via the NLRP3 Inflammasome

D. Shima, O. A. Anderson, Arthur Finkelstein, 2013, PloS one.

Targeting key angiogenic pathways with a bispecific CrossMAb optimized for neovascular eye diseases

C. Klein, K. Stubenrauch, D. Shima, 2017, EMBO molecular medicine.

VEGF-A Is Necessary and Sufficient for Retinal Neuroprotection in Models of Experimental Glaucoma

P. Khaw, J. Morgan, D. Shima, 2013, The American journal of pathology.

Golgi clusters and vesicles mediate mitotic inheritance independently of the endoplasmic reticulum

E. Jokitalo, G. Warren, D. Shima, 2001, The Journal of cell biology.

Reduced Glomerular Filtration in Diabetes Is Attributable to Loss of Density and Increased Resistance of Glomerular Endothelial Cell Fenestrations

S. Harper, D. Shima, H. Band, 2022, Journal of the American Society of Nephrology : JASN.

Experimental Glaucoma Induced by Ocular Injection of Magnetic Microspheres

P. Khaw, D. Shima, A. Dahlmann-Noor, 2015, Journal of visualized experiments : JoVE.

1 A pro-inflammatory function of toll-like receptor 2 in the retinal pigment epithelium 2 as a novel target for reducing choroidal neovascularization in age-related macular 3 degeneration 4

P. Adamson, D. Shima, K. Lashkari, 2018 .

A Proinflammatory Function of Toll-Like Receptor 2 in the Retinal Pigment Epithelium as a Novel Target for Reducing Choroidal Neovascularization in Age-Related Macular Degeneration.

P. Adamson, D. Shima, K. Lashkari, 2017, The American journal of pathology.

Targeting key angiogenic pathways with a bispecific CrossMAb optimized for neovascular eye diseases

C. Klein, K. Stubenrauch, C. Cheung, 2016, EMBO molecular medicine.

Distal retinal ganglion cell axon transport loss and activation of p38 MAPK stress pathway following VEGF-A antagonism

K. Martin, D. Shima, Y. Ng, 2016, Cell Death and Disease.

PKCalpha regulates beta1 integrin-dependent cell motility through association and control of integrin traffic.

P. Bastiaens, P. Parker, M. Humphries, 1999, The EMBO journal.

Spontaneous CNV in a novel mutant mouse is associated with early VEGF-A-driven angiogenesis and late-stage focal edema, neural cell loss, and dysfunction.

P. Adamson, D. Shima, A. Adamis, 2014, Investigative ophthalmology & visual science.

VEGF Has Both Direct and Indirect Neuroprotective Effects in Ischemic Retina

D. Shima, E. Ng, A. Adamis, 2006 .

Inhibitory effect of an antibody to cryptic collagen type IV epitopes on choroidal neovascularization.

C. Mailhos, D. Shima, A. Adamis, 2004, Molecular vision.

Illuminating cellular structure and function in the early secretory pathway by multispectral 3D imaging in living cells

Rainer Pepperkok, Jeremy C. Simpson, David T. Shima, 2000, Photonics West - Biomedical Optics.

VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia

K. Alitalo, C. Betsholtz, H. Gerhardt, 2003, The Journal of cell biology.

VEGF–mediated neuroprotection in ischemic retina

D. Shima, A. Adamis, N. Jo, 2004 .

Decapping and Decay of Messenger RNA Occur in Cytoplasmic Processing Bodies

E. Fisher, H. Fuchs, M. Angelis, 2003 .

Targeting key angiogenic pathways with a bispecific CrossMAb optimized for neovascular eye diseases

C. Klein, K. Stubenrauch, D. Shima, 2019, EMBO Molecular Medicine.

Transgenic mouse capable of over-expressing vascular endothelial protein tyrosine phosphatase (ve-ptp)

D. Shima, S. Ioannidou, 2005 .

Golgi clusters and vesicles mediate mitotic inheritance independently of the endoplasmic reticulum

E. Jokitalo, G. Warren, D. Shima, 2001, The Journal of cell biology.

An Ordered Inheritance Strategy for the Golgi Apparatus: Visualization of Mitotic Disassembly Reveals a Role for the Mitotic Spindle

R. Pepperkok, G. Warren, D. Shima, 1998, The Journal of cell biology.