J. Whitlock

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Efficient metabolism of benzo(a)pyrene at nanomolar concentrations by intact murine hepatoma cells.

A. Miller, J. Whitlock, 1982, Cancer research.

Rodent-specific hypoxia response elements enhance PAI-1 expression through HIF-1 or HIF-2 in mouse hepatoma cells.

W. An, C. Eom, J. Whitlock, 2010, International journal of oncology.

J. Whitlock, L. Dong, Liqun Dong, 1998, The Journal of Biological Chemistry.

Control of gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Multiple dioxin-responsive domains 5'-ward of the cytochrome P1-450 gene.

J. Whitlock, J. M. Fisher, P. B. Jones, 1986, The Journal of biological chemistry.

Protein-DNA interactions at a dioxin-responsive enhancer. Evidence that the transformed Ah receptor is heteromeric.

J. Whitlock, C. Elferink, T. Gasiewicz, 1990, The Journal of biological chemistry.

Transcriptional activation function of the mouse Ah receptor nuclear translocator.

H. Li, J. Whitlock, L. Dong, 1994, The Journal of biological chemistry.

Protein-DNA interactions at recognition sites for the dioxin-Ah receptor complex.

J. Whitlock, M. Denison, J. M. Fisher, 1989, The Journal of biological chemistry.

Removal of histone H1 exposes a fifty base pair DNA segment between nucleosomes.

J. Whitlock, R. Simpson, 1976, Biochemistry.

Folding of DNA by histones which lack their NH2-terminal regions.

A. Stein, J. Whitlock, 1978, The Journal of biological chemistry.

Evaluation Of Afuresertib, An Oral Pan-AKT Inhibitor, In Patients With Langerhans Cell Histiocytosis

R. Arceci, E. Jacobsen, C. Rodríguez-Galindo, 2013 .

Dioxin-induced CYP1A1 transcription in vivo: the aromatic hydrocarbon receptor mediates transactivation, enhancer-promoter communication, and changes in chromatin structure

J. Whitlock, S. Okino, Q. Ma, 1996, Molecular and cellular biology.

Myb-binding Protein 1a Augments AhR-dependent Gene Expression*

J. Whitlock, T. Gonda, S. Okino, 2002, The Journal of Biological Chemistry.

Transactivation domains facilitate promoter occupancy for the dioxin-inducible CYP1A1 gene in vivo

J. Whitlock, S. Okino, Q. Ma, 1997, Molecular and cellular biology.

Down-regulation of Major Histocompatibility ComplexQ1 b Gene Expression by 2,3,7,8-Tetrachlorodibenzo-p-dioxin*

J. Whitlock, Q. Ma, L. Dong, 1997, The Journal of Biological Chemistry.

Induction of mRNA specific for cytochrome P1-450 in wild type and variant mouse hepatoma cells.

J. Whitlock, D. Israel, 1983, The Journal of biological chemistry.

Organization and function of a dioxin-responsive enhancer.

L. Wu, J. Whitlock, M. Denison, 1990, The Journal of biological chemistry.

Transcription-dependent and transcription-independent nucleosome disruption induced by dioxin.

J. Whitlock, J. Morgan, 1992, Proceedings of the National Academy of Sciences of the United States of America.

The aromatic hydrocarbon receptor modulates the Hepa 1c1c7 cell cycle and differentiated state independently of dioxin

J. Whitlock, Q. Ma, Qiang Ma, 1996, Molecular and cellular biology.

Cytological and molecular remissions with blinatumomab treatment in second or later bone marrow relapse in pediatric acute lymphoblastic leukemia (ALL).

A. Borkhardt, C. Zwaan, J. Whitlock, 2013 .

Induction of hepatic cytochrome P450 gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

J. Whitlock, M. Denison, E. Shen, 1989, Molecular biology & medicine.

Genetic and molecular aspects of 2,3,7,8-tetrachlorodibenzo-p-dioxin action.

J. Whitlock, Jr Jp Whitlock, 1990, Annual review of pharmacology and toxicology.

Induction of cytochrome P4501A1.

J. Whitlock, J P Whitlock, J. J. P. Whitlock, 1999, Annual review of pharmacology and toxicology.

The potential role of DNA methylation in the response to 2,3,7,8-tetrachlorodibenzo-p-dioxin.

J. Whitlock, E. Shen, 1989, The Journal of biological chemistry.

Dioxin-induced CYP1A1 transcription in vivo: the aromatic hydrocarbon receptor mediates transactivation, enhancer-promoter communication, and changes in chromatin structure

J. Whitlock, S. Okino, Q. Ma, 1996, Molecular and cellular biology.

Protein-DNA interactions at a dioxin-responsive enhancer. Mutational analysis of the DNA-binding site for the liganded Ah receptor.

J. Whitlock, E. Shen, J. Whitlock, 1992, The Journal of biological chemistry.

Control of cytochrome P1-450 gene expression: analysis of a dioxin-responsive enhancer system.

J. Whitlock, P. B. Jones, L. Durrin, 1986, Proceedings of the National Academy of Sciences of the United States of America.

2,3,7,8-Tetrachlorodibenzo-p-dioxin-inducible, Ah receptor-mediated bending of enhancer DNA.

J. Whitlock, C. Elferink, J. Whitlock, 1990, The Journal of biological chemistry.

Control of cytochrome P1-450 gene expression by dioxin.

J. Whitlock, P. B. Jones, J. Fisher, 1985, Science.

Regulation of cytochrome P1-450 gene expression in mouse hepatoma cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

J. Whitlock, M. Denison, P. B. Jones, 1989, Drug metabolism reviews.

In situ protein-DNA interactions at a dioxin-responsive enhancer associated with the cytochrome P1-450 gene

J. Whitlock, L. Durrin, 1987, Molecular and cellular biology.

The regulation of cytochrome P-450 gene expression.

J. Whitlock, 1986, Annual review of pharmacology and toxicology.

Use of gel retardation to analyze protein-DNA interactions upstream of CYPIA1 gene.

J. Whitlock, C. Elferink, E. Shen, 1991, Methods in enzymology.

Regulation of cytochrome P1-450 gene transcription by 2,3,7, 8-tetrachlorodibenzo-p-dioxin in wild type and variant mouse hepatoma cells.

J. Whitlock, D. Israel, 1984, The Journal of biological chemistry.

Activation of transcription as a general mechanism of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin action

J. Whitlock, K. Jones, J. Fisher, 1989, Molecular carcinogenesis.

INDUCTION OF ARYL HYDROCARBON (BENZO[a]PYRENE) HYDROXYLASE AND TYROSINE AMINOTRANSFERASE IN HEPATOMA CELLS IN CULTURE

J. Whitlock, H. Gelboin, H. Miller, 1974, The Journal of cell biology.

Superinduction of cytochrome P1-450 gene transcription by inhibition of protein synthesis in wild type and variant mouse hepatoma cells.

J. Whitlock, D. Israel, D. Galeazzi, 1985, The Journal of biological chemistry.

2,3,7,8-Tetrachlorodibenzo-p-dioxin receptors in wild type and variant mouse hepatoma cells. Nuclear location and strength of nuclear binding.

J. Whitlock, D. Galeazzi, 1984, The Journal of biological chemistry.

Aryl hydrocarbon (benzo(a)pyrene) hydroxylase in human peripheral blood monocytes

R. Bast, J. Whitlock, H. Rapp, 1974, Nature.

Protein-DNA interactions at a dioxin-responsive enhancer. Analysis of six bona fide DNA-binding sites for the liganded Ah receptor.

J. Whitlock, E. Shen, A. Lusska, 1993, The Journal of biological chemistry.

ARYL HYDROCARBON HYDROXYLASE AND BENZO[A] PYRENE METABOLISM IN RODENT LIVER AND HUMAN CELLS

J. Whitlock, H. Gelboin, J. Whitlock, 1980 .

Aryl hydrocarbon (benzo(a)pyrene) hydroxylase induction in cells in culture.

J. Whitlock, H. Gelboin, 1979, Pharmacology & therapeutics. Part B: General & systematic pharmacology.

Benzo[a]pyrene Metabolism: Enzymatic and Liquid Chromatographic Analysis and Application to Human Liver, Lymphocytes, and Monocytes

R. Bast, J. Selkirk, J. Whitlock, 1977 .

Variation in aryl hydrocarbon (benzo(a)pyrene) hydroxylase activity in heteroploid and predominantly diploid rat liver cells in culture

J. Whitlock, H. Coon, H. Gelboin, 1976, The Journal of cell biology.

In vitro metabolism of benzo(a)pyrene by human liver microsomes and lymphocytes.

J. Selkirk, J. Whitlock, H. Gelboin, 1975, Cancer research.

MAMMALIAN ARYL HYDROCARBON HYDROXYLASES IN CELL CULTURES: MECHANISM OF INDUCTION AND ROLE IN CARCINOGENESIS

J. Whitlock, H. Gelboin, F. Wiebel, 1974 .

Localization of the sites along nucleosome DNA which interact with NH2-terminal histone regions.

J. Whitlock, R. Simpson, 1977, The Journal of biological chemistry.

2,3,7,8-Tetrachlorodibenzo-p-dioxin-inducible aryl hydrocarbon receptor-mediated change in CYP1A1 chromatin structure occurs independently of transcription

J. Whitlock, L. Durrin, 1989, Molecular and cellular biology.

6 – Interactions between Benzo[a]pyrene Diol Epoxide I and Chromatin

J. Whitlock, 1978 .

Novel variants in benzo(a)pyrene metabolism. Isolation by fluorescence-activated cell sorting.

A. Miller, J. Whitlock, 1981, The Journal of biological chemistry.

Superinduction of CYP1A1 transcription by cycloheximide. Role of the DNA binding site for the liganded Ah receptor.

L. Wu, J. Whitlock, A. Lusska, 1992, The Journal of biological chemistry.

How I treat ALL in Down's syndrome: pathobiology and management.

C. Zwaan, S. Izraeli, J. Whitlock, 2014, Blood.

Canadian profiling and targeted agent utilization trial (CAPTUR/PM.1): A phase II basket precision medicine trial.

Steven J. M. Jones, Bingshu E. Chen, J. Dancey, 2018 .

Carcinogen-induced alteration of DNA structure.

N. Dattagupta, M. Hogan, J. Whitlock, 1981, The Journal of biological chemistry.

Acidic polypeptides can assemble both histones and chromatin in vitro at physiological ionic strength.

A. Stein, M. Bina, J. Whitlock, 1979, Proceedings of the National Academy of Sciences of the United States of America.

Mapping DNAase I-susceptible sites in nucleosomes labeled at the 5′ ends

J. Whitlock, R. Simpson, 1976, Cell.

Dioxin-inducible, Ah receptor-dependent transcription in vitro.

J. Whitlock, L. Wen, N. Koeiman, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Phase 1 study of dabrafenib in pediatric patients (pts) with relapsed or refractory BRAF V600E high- and low-grade gliomas (HGG, LGG), Langerhans cell histiocytosis (LCH), and other solid tumors (OST).

C. Pratilas, B. Geoerger, P. Haney, 2015 .

2′‐chlorodeoxyadenosine (2‐CdA) as salvage therapy for Langerhans cell histiocytosis (LCH). results of the LCH‐S‐98 protocol of the histiocyte society

R. Arceci, J. Whitlock, U. Pötschger, 2009, Pediatric blood & cancer.

Aryl Hydrocarbon (Benzopyrene) Hydroxylase Is Stimulated in Human Lymphocytes by Mitogens and Benz[a]anthracene

J. Whitlock, H. Gelboin, H. Cooper, 1972, Science.

Changes in thymidine kinase and alpha-amylase activity during isoproterenol-stimulated DNA synthesis in mouse salivary gland.

J. Whitlock, R. Baserga, R. Kaufman, 1968, Cancer research.

Biochemical and genetic analysis of variant mouse hepatoma cells which overtranscribe the cytochrome P1-450 gene in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin.

A. Miller, J. Whitlock, D. Israel, 1984, The Journal of biological chemistry.

Calcium-dependent phosphorylation of histone H3 in butyrate-treated HeLa cells

H. Schulman, J. Whitlock, R. Augustine, 1980, Nature.

A phase IIa study of afuresertib, an oral pan‐AKT inhibitor, in patients with Langerhans cell histiocytosis

R. Arceci, M. Cornfeld, E. Jacobsen, 2017, Pediatric Blood & Cancer.

Dioxin induces localized, graded changes in chromatin structure: implications for Cyp1A1 gene transcription

J. Whitlock, S. Okino, 1995, Molecular and cellular biology.

Functional analysis of the transcriptional promoter for the CYP1A1 gene

J. Whitlock, K. Jones, 1990, Molecular and cellular biology.

Preparation and physical characterization of a homogeneous population of monomeric nucleosomes from HeLa cells.

J. Whitlock, R. Simpson, 1976, Nucleic acids research.

Use of cDNA microarrays to analyze dioxin-induced changes in human liver gene expression.

P. Brown, K. Hayashibara, F. Frueh, 2001, Toxicology letters.

Mechanism of dioxin action: Ah receptor-mediated increase in promoter accessibility in vivo.

L. Wu, J. Whitlock, J. Whitlock, 1992, Proceedings of the National Academy of Sciences of the United States of America.

The control of cytochrome P-450 gene expression by dioxin.

J. Whitlock, J. Whitlock, 1989, Trends in pharmacological sciences.

Acetylation and calcium-dependent phosphorylation of histone H3 in nuclei from butyrate-treated HeLa cells.

H. Schulman, J. Whitlock, D. Galeazzi, 1983, The Journal of biological chemistry.

Chemical evidence that chromatin DNA exists as 160 base pair beads interspersed with 40 base pair bridges

R. T. Simpson, J. P. Whitlock, J. Whitlock, 1976, Nucleic Acids Res..

Inducible, receptor-dependent protein-DNA interactions at a dioxin-responsive transcriptional enhancer.

J. Whitlock, M. Denison, J. Fisher, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Nelarabine in Combination with Etoposide and Cyclophosphamide Is Active in First Relapse of Childhood T-Acute Lymphocytic Leukemia (T-ALL) and T-Lymphoblastic Lymphoma (T-LL)

L. Silverman, B. Wood, C. Zwaan, 2014 .

GENETIC AND MOLECULAR

J. Whitlock, 1990 .

The aromatic hydrocarbon receptor, dioxin action, and endocrine homeostasis

J. Whitlock, 1994, Trends in Endocrinology & Metabolism.

Induction of Cytochrome P450 Enzymes That Metabolize Xenobiotics

J. Whitlock, M. Denison, 1995 .

Biochemical and genetic analysis of variant mouse hepatoma cells defective in the induction of benzo(a)pyrene-metabolizing enzyme activity.

A. Miller, J. Whitlock, D. Israel, 1983, The Journal of biological chemistry.

Preparation and properties of a new DNase from Aspergillus oryzae.

J. Whitlock, G. W. Rushizky, 1977, Biochemistry.

Accessibility and activity of the promoter for a dioxin-inducible ecto-ATPase gene.

J. Whitlock, L. Gao, 2001, Archives of biochemistry and biophysics.

The DNA recognition site for the dioxin-Ah receptor complex. Nucleotide sequence and functional analysis.

J. Whitlock, M. Denison, J. Fisher, 1988, The Journal of biological chemistry.

Mechanistic aspects of dioxin action.

J. Whitlock, J. Whitlock, 1993, Chemical research in toxicology.

Induction of drug-metabolizing enzymes by dioxin.

J. Whitlock, S. Okino, Liqun Dong, 1997, Drug metabolism reviews.

2,3,7,8-Tetrachlorodibenzo-p-dioxin induces cytochrome P450IA1 enzyme activity by activating transcription of the corresponding gene.

L. Wu, J. Whitlock, C. Elferink, 1991, Advances in enzyme regulation.

The aromatic hydrocarbon receptor, transcription, and endocrine aspects of dioxin action.

J. Whitlock, S. Okino, J. Whitlock, 2000, Vitamins and hormones.

Aryl hydrocarbon (benzo(a)pyrene) hydroxylase induction in rat liver cells in culture.

J. Whitlock, H. Gelboin, 1974, The Journal of biological chemistry.

Tumor Promotion by 2,3,7,8-Tetrachlorodibenzo-p-dioxin

J. Whitlock, 2020 .

2,3,7,8-Tetrachl orodibenzo-p-Dioxin-Inducible ArylHydrocarbon Receptor-Mediated ChangeinCYPIAJChromatin Structure OccursIndependently ofTranscription

J. Whitlock, L. Durrin, 1989 .

The regulation of gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

J. Whitlock, 1987, Pharmacological reviews.

Induction of aryl hydrocarbon (benzo(a)pyrene) hydroxylase in liver cell culture by temporary inhibition of protein synthesis.

J. Whitlock, H. Gelboin, 1973, The Journal of biological chemistry.

Mechanism of dioxin action: receptor-enhancer interactions in intact cells

Lena Wu, James P. Whitlock, J. Whitlock, 1993, Nucleic Acids Res..

DNase-sensitive sites in nucleosomes. Their relative suspectibilities depend on nuclease used.

J. Whitlock, G. W. Rushizky, R. Simpson, 1977, The Journal of biological chemistry.

Dioxin-dependent, DNA sequence-specific binding of a multiprotein complex containing the Ah receptor.

J. Whitlock, C. Elferink, 1994, Receptor.

Initial Results from a Phase 2 Study of Blinatumomab in Pediatric Patients with Relapsed/Refractory B-Cell Precursor Acute Lymphoblastic Leukemia

C. Zwaan, J. Whitlock, F. Locatelli, 2014 .

Clinical presentation and risk factors of serious infections in children with Down syndrome treated for acute lymphoblastic leukemia

J. Whitlock, J. Krueger, D. Stephens, 2016, Pediatric blood & cancer.

First report of t(5;11) KMT2A-MAML1 fusion in de novo infant acute lymphoblastic leukemia.

M. Shago, A. Shlien, J. Whitlock, 2020, Cancer genetics.

Bortezomib reinduction therapy to improve response rates in pediatric ALL in first relapse: A Children’s Oncology Group (COG) study (AALL07P1).

Xiaomin Lu, S. Hunger, M. Borowitz, 2013 .

Outcomes after Intermediate-Risk Relapse of Childhood B-Lymphoblastic Leukemia (B-ALL) and the Role of Allogeneic Stem Cell Transplantation (SCT): A Report from Children's Oncology Group (COG) AALL0433

Xiaomin Lu, S. Hunger, M. Borowitz, 2014 .

Phase 1/2 Study in Pediatric Patients with Relapsed/Refractory B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) Receiving Blinatumomab Treatment

A. Borkhardt, C. Zwaan, J. Whitlock, 2014 .