C. Schéele

发表

Kinetics of Senescence-associated Changes of Gene Expression in an Epithelial, Temperature-sensitive SV40 Large T Antigen Model

Claes Wahlestedt, Ola Larsson, C. Wahlestedt, 2004, Cancer Research.

Altered regulation of the PINK1 locus: a link between type 2 diabetes and neurodegeneration?

C. Wahlestedt, J. Timmons, O. Larsson, 2007, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

The human PINK1 locus is regulated in vivo by a non-coding natural antisense RNA during modulation of mitochondrial function

T. Lassmann, C. Wahlestedt, J. Timmons, 2007, BMC Genomics.

Using molecular classification to predict gains in maximal aerobic capacity following endurance exercise training in humans.

Claude Bouchard, Steven L Britton, Tuomo Rankinen, 2010, Journal of applied physiology.

Impaired Leptin Gene Expression and Release in Cultured Preadipocytes Isolated From Individuals Born With Low Birth Weight

A. Vaag, B. Pedersen, C. Schéele, 2013, Diabetes.

Functional Genomics Studies of PINK1

C. Schéele, 2007 .

Altered brown fat thermoregulation and enhanced cold-induced thermogenesis in young, healthy, winter-swimming men

B. Pedersen, A. Hansen, H. Johannesen, 2021, Cell reports. Medicine.

LIF is a contraction-induced myokine stimulating human myocyte proliferation.

B. Pedersen, C. Schéele, H. Pilegaard, 2011, Journal of applied physiology.

Osteogenesis depends on commissioning of a network of stem cell transcription factors that act as repressors of adipogenesis

Anders K. Haakonsson, J. Baumbach, S. Mandrup, 2019, Nature Genetics.

training in humans exercise maximal aerobic capacity following endurance Using molecular classification to predict gains in

C. Bouchard, N. Vollaard, C. Wahlestedt, 2015 .

Elevated NFk B Activation Is Conserved in Human Myocytes Cultured From Obese Type 2 Diabetic Patients and Attenuated by AMP-Activated Protein Kinase

B. Pedersen, C. Schéele, M. Pedersen, 2011 .

Elevated NF-κB Activation Is Conserved in Human Myocytes Cultured From Obese Type 2 Diabetic Patients and Attenuated by AMP-Activated Protein Kinase

B. Pedersen, C. Schéele, M. Pedersen, 2011, Diabetes.

Brown Fat AKT2 Is a Cold-Induced Kinase that Stimulates ChREBP-Mediated De Novo Lipogenesis to Optimize Fuel Storage and Thermogenesis.

Christian M. Metallo, D. Guertin, S. Gujja, 2018, Cell metabolism.

Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function.

B. Kemp, J. Ortega, C. Schéele, 2016, Cell metabolism.

Using functional genomics to study PINK1 and metabolic physiology.

J. Timmons, O. Larsson, C. Schéele, 2009, Methods in enzymology.

An anti-inflammatory phenotype in visceral adipose tissue of old lean mice, augmented by exercise

M. Kjaer, C. Schéele, P. Schjerling, 2019, Scientific Reports.

Angiogenic and inflammatory biomarkers for screening and follow-up in patients with pulmonary arterial hypertension

C. Schéele, G. Rådegran, R. Hesselstrand, 2018, Scandinavian journal of rheumatology.

Human brown adipose tissue is phenocopied by classical brown adipose tissue in physiologically humanized mice

C. Schéele, P. Nuutila, N. Petrovic, 2019, Nature Metabolism.

Endogenous Fatty Acid Synthesis Drives Brown Adipose Tissue Involution

C. Schéele, M. Schweizer, Y. Tseng, 2021, Cell reports.

IL-6 myokine signaling in skeletal muscle : a double-edged sword ?

B. Pedersen, C. Schéele, P. Muñoz-Cánoves, 2013 .

Interleukin‐6 myokine signaling in skeletal muscle: a double‐edged sword?

B. Pedersen, C. Schéele, P. Muñoz-Cánoves, 2013, The FEBS journal.

obese elderly persons skeletal muscle inflammatory gene expression in frail Exercise but not diet-induced weight loss decreases

B. Pedersen, C. Schéele, D. Cameron-Smith, 2010 .

Exercise and browning of white adipose tissue - a translational perspective.

B. Pedersen, C. Schéele, M. C. Severinsen, 2020, Current opinion in pharmacology.

Human Brown Adipocyte Thermogenesis Is Driven by β2-AR Stimulation.

C. Schéele, A. Carpentier, F. Haman, 2020, Cell metabolism.

Brown Adipose Crosstalk in Tissue Plasticity and Human Metabolism

C. Schéele, C. Wolfrum, 2019, Endocrine reviews.

Coagulation factors promote brown adipose tissue dysfunction and abnormal systemic metabolism in obesity

Shujiro Okuda, C. Schéele, T. Minamino, 2022, iScience.

Gamma-Aminobutyric Acid Signaling in Brown Adipose Tissue Promotes Systemic Metabolic Derangement in Obesity.

T. Soga, C. Schéele, T. Minamino, 2018, Cell reports.

Calsyntenin 3β Is Dynamically Regulated by Temperature in Murine Brown Adipose and Marks Human Multilocular Fat

B. Emanuelli, C. Schéele, Naja Jespersen, 2020, Frontiers in Endocrinology.

Adenosine activates brown adipose tissue and recruits beige adipocytes via A2A receptors

C. Müller, P. Brust, S. Enerbäck, 2014, Nature.

Fetal Hyperglycemia Changes Human Preadipocyte Function in Adult Life

C. Ling, A. Vaag, B. Pedersen, 2017, The Journal of clinical endocrinology and metabolism.

Satellite Cells Derived from Obese Humans with Type 2 Diabetes and Differentiated into Myocytes In Vitro Exhibit Abnormal Response to IL-6

B. Pedersen, C. Schéele, C. Fischer, 2012, PloS one.

ROS and myokines promote muscle adaptation to exercise

B. Pedersen, C. Schéele, Søren Nielsen, 2009, Trends in Endocrinology & Metabolism.

In Vitro Palmitate Treatment of Myotubes from Postmenopausal Women Leads to Ceramide Accumulation, Inflammation and Affected Insulin Signaling

B. Pedersen, C. Schéele, D. Henstridge, 2014, PloS one.

Adipogenesis in Primary Cell Culture.

C. Schéele, Naja Jespersen, T. J. Larsen, 2019, Handbook of experimental pharmacology.

Novel nuances of human brown fat

C. Schéele, Søren Nielsen, T. J. Larsen, 2014, Adipocyte.

Brown Adipose Tissue: A Metabolic Regulator in a Hypothalamic Cross Talk?

C. Schéele, J. Henningsen, 2020, Annual review of physiology.

Plasma sFlt-1 Fluctuations in Response to Pulmonary ArterialHypertension Treatment

C. Schéele, G. Rådegran, S. Nielsen, 2017 .

Human BAT Thermogenesis is Stimulated by the β 2-Adrenergic Receptor

C. Schéele, A. Carpentier, F. Haman, 2019, SSRN Electronic Journal.

Adenosine/A2B Receptor Signaling Ameliorates the Effects of Aging and Counteracts Obesity.

P. Brust, C. Dani, B. Fleischmann, 2022, Cell metabolism.

Biochemistry 2007

J. Timmons, C. Schéele, K. Clarke, 2008 .

Human visceral and subcutaneous adipose stem and progenitor cells retain depot-specific adipogenic properties during obesity

B. Pedersen, C. Schéele, M. Watt, 2022, Frontiers in Cell and Developmental Biology.

Diverse repertoire of human adipocyte subtypes develops from transcriptionally distinct mesenchymal progenitor cells

Lawrence M. Lifshitz, R. Maehr, M. Garber, 2019, Proceedings of the National Academy of Sciences.

The human batokine EPDR1 regulates β-cell metabolism and function

L. Eliasson, R. Prasad, P. Spégel, 2022, Molecular metabolism.

Adenosine/A2B Receptor Signaling Ameliorates the Effects of Aging and Counteracts Obesity.

L. Pardo, P. Brust, C. Dani, 2020, Cell metabolism.

Altered DNA Methylation and Differential Expression of Genes Influencing Metabolism and Inflammation in Adipose Tissue From Subjects With Type 2 Diabetes

C. Ling, P. Poulsen, A. Vaag, 2014, Diabetes.

MultiPep: a hierarchical deep learning approach for multi-label classification of peptide bioactivities

Alexander G. B. Grønning, T. Kacprowski, C. Schéele, 2021, Biology methods & protocols.

Sex influences DNA methylation and gene expression in human skeletal muscle myoblasts and myotubes

C. Ling, B. Pedersen, C. Schéele, 2019, Stem Cell Research & Therapy.

Integration of microRNA changes in vivo identifies novel molecular features of muscle insulin resistance in type 2 diabetes

Claes Wahlestedt, Gyorgy Hutvagner, J. Babraj, 2010, Genome Medicine.

NFIA co-localizes with PPARγ and transcriptionally controls the brown fat gene program

H. Aburatani, C. Schéele, T. Kadowaki, 2017, Nature Cell Biology.

The miRNA Plasma Signature in Response to Acute Aerobic Exercise and Endurance Training

B. Pedersen, C. Schéele, M. Laye, 2014, PloS one.

A classical brown adipose tissue mRNA signature partly overlaps with brite in the supraclavicular region of adult humans.

B. Pedersen, C. Schéele, P. Homøe, 2013, Cell metabolism.

Thermogenic genes are blunted whereas brown adipose tissue identity is preserved in human obesity

S. Mandrup, B. Pedersen, C. Schéele, 2020, bioRxiv.

Proteomics-Based Comparative Mapping of the Secretomes of Human Brown and White Adipocytes Reveals EPDR1 as a Novel Batokine.

M. Mann, D. Drucker, C. H. Nielsen, 2019, Cell metabolism.

Electronic Supplementary Material -methods

P. Poulsen, A. Vaag, T. Litman, 2022 .

VPS39-deficiency observed in type 2 diabetes impairs muscle stem cell differentiation via altered autophagy and epigenetics

C. Ling, A. Vaag, O. Hansson, 2021, Nature Communications.

Abnormal epigenetic changes during differentiation of human skeletal muscle stem cells from obese subjects

L. Joosten, C. Ling, A. Vaag, 2017, BMC Medicine.

Epigenetic programming of adipose-derived stem cells in low birthweight individuals

C. Ling, A. Vaag, C. Schéele, 2016, Diabetologia.

Muscle specific miRNAs are induced by testosterone and independently upregulated by age

B. Pedersen, C. Schéele, M. Laye, 2014, Front. Physiol..

Human thermogenic adipocyte regulation by the long noncoding RNA LINC00473

B. Emanuelli, H. Willenbrock, B. Pedersen, 2020, Nature metabolism.

Epigenome- and Transcriptome-wide Changes in Muscle Stem Cells from Low Birth Weight Men

C. Ling, A. Vaag, B. Pedersen, 2020, Endocrine research.

Dysregulation of Mitochondrial Dynamics and the Muscle Transcriptome in ICU Patients Suffering from Sepsis Induced Multiple Organ Failure

J. Timmons, B. Ahlman, J. Wernerman, 2008, PloS one.

Expression profiling following local muscle inactivity in humans provides new perspective on diabetes-related genes.

C. Wahlestedt, P. Tesch, J. Timmons, 2006, Genomics.

A long-non-coding RNA, LINC00473, confers the human adipose tissue thermogenic phenotype through enhanced cAMP responsiveness

H. Willenbrock, B. Pedersen, Tiffany DeSouza, 2018, bioRxiv.

Heterogeneity in the perirenal region of humans suggests presence of dormant brown adipose tissue that contains brown fat precursor cells

B. Pedersen, C. Schéele, N. S. Hansen, 2019, Molecular metabolism.

Asymmetric perirenal brown adipose dormancy in adult humans is defined by local sympathetic activity

B. Pedersen, C. Schéele, N. S. Hansen, 2018, bioRxiv.

Characterization of RNA interference in rat PC12 cells: requirement of GERp95.

C. Wahlestedt, C. Schéele, H. Thonberg, 2004, Biochemical and biophysical research communications.

Single Cell Analysis Identifies the miRNA Expression Profile of a Subpopulation of Muscle Precursor Cells Unique to Humans With Type 2 Diabetes

B. Pedersen, C. Schéele, N. S. Hansen, 2018, Front. Physiol..

Muscle specific microRNAs are regulated by endurance exercise in human skeletal muscle

C. Schéele, B. K. Pedersen, A. Nielsen, 2010, The Journal of physiology.

Dysregulated autophagy in muscle precursor cells from humans with type 2 diabetes

C. Schéele, B. K. Pedersen, M. Sandri, 2019, Scientific Reports.

Metabolic regulation and the anti-obesity perspectives of human brown fat

C. Schéele, Søren Nielsen, 2017, Redox biology.

Adipose adaptation to exercise training –increased metabolic rate but no signs of browning

C. Schéele, 2014, Acta physiologica.

Deficient leukemia inhibitory factor signaling in muscle precursor cells from patients with type 2 diabetes.

B. Pedersen, C. Schéele, A. Nielsen, 2012, American journal of physiology. Endocrinology and metabolism.

Deep muscle-proteomic analysis of freeze-dried human muscle biopsies reveals fiber type-specific adaptations to exercise training

M. Mann, M. Murgia, C. Schéele, 2021, Nature communications.

Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis

Xianlin Han, T. Hansen, O. Pedersen, 2018, Cell metabolism.

Dysregulation of a novel miR-23b/27b-p53 axis impairs muscle stem cell differentiation of humans with type 2 diabetes

Peter K. Davidsen, A. Vaag, B. Pedersen, 2017, Molecular metabolism.

Human thermogenic adipocyte regulation by the long noncoding RNA LINC00473

B. Emanuelli, H. Willenbrock, B. Pedersen, 2020, Nature Metabolism.

Type 2 diabetes and obesity induce similar transcriptional reprogramming in human myocytes

Jens Nielsen, Mathias Uhlén, Bente Klarlund Pedersen, 2017, Genome Medicine.

Activity-induced and developmental downregulation of the Nogo receptor

C. Spenger, C. Wahlestedt, A. Josephson, 2003, Cell and Tissue Research.

Human brown adipose tissue is phenocopied by classical brown adipose tissue in physiologically humanized mice

C. Schéele, P. Nuutila, N. Petrovic, 2019, Nature Metabolism.

Exercise as a Model to Study Interactions Between Oxidative Stress and Inflammation

B. Pedersen, C. Schéele, S. Nielsen, 2011 .

Proteome- and Transcriptome-Driven Reconstruction of the Human Myocyte Metabolic Network and Its Use for Identification of Markers for Diabetes.

Intawat Nookaew, Jens Nielsen, Caroline Kampf, 2016, Cell reports.

Proteome- and transcriptome-driven reconstruction of the human myocyte metabolic network and its use for identification of markers for diabetes.

Intawat Nookaew, Jens Nielsen, Caroline Kampf, 2015, Cell reports.

Challenges in tackling energy expenditure as obesity therapy: From preclinical models to clinical application

H. Zimdahl, W. Langhans, C. Schéele, 2021, Molecular metabolism.

FGF21 Is a Sugar-Induced Hormone Associated with Sweet Intake and Preference in Humans.

T. Hansen, O. Pedersen, N. Grarup, 2017, Cell metabolism.

Proteomics-based comparative mapping of the human brown and white adipocyte secretome reveals EPDR1 as a novel batokine

M. Mann, B. Holst, B. Pedersen, 2018, bioRxiv.

Sex influences DNA methylation and gene expression in human skeletal muscle myoblasts and myotubes

C. Ling, B. Pedersen, C. Schéele, 2019, Stem Cell Research & Therapy.

Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis

T. Hansen, O. Pedersen, N. Grarup, 2021, Cell.

Deep muscle-proteomic analysis of freeze-dried human muscle biopsies reveals fiber type-specific adaptations to exercise training

M. Murgia, C. Schéele, E. Richter, 2021, Nature Communications.

Physical activity is associated with retained muscle metabolism in human myotubes challenged with palmitate

C. Schéele, B. K. Pedersen, T. Bunprajun, 2013, The Journal of physiology.

Lifelong Physical Activity Prevents Aging-Associated Insulin Resistance in Human Skeletal Muscle Myotubes via Increased Glucose Transporter Expression

B. Pedersen, C. Schéele, C. Green, 2013, PloS one.

Correction: Dysregulation of Mitochondrial Dynamics and the Muscle Transcriptome in ICU Patients Suffering from Sepsis Induced Multiple Organ Failure

J. Timmons, B. Ahlman, J. Wernerman, 2008, PLoS ONE.

Temporal trajectories of human brown and white adipocyte progenitors at single cell resolution

Alexander G. B. Grønning, Nagendra P. Palani, T. Pers, 2022 .

Genomic variants at the PINK1 locus are associated with transcript abundance and plasma nonesterified fatty acid concentrations in European whites

C. Wahlestedt, N. Wareham, P. Franks, 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Do mitochondria provide a common link between diabetes and Parkinson's disease?

C. Wahlestedt, J. Timmons, C. Schéele, 2007 .

Adipogenic and SWAT cells separate from a common progenitor in human brown and white adipose depots

Alexander G. B. Grønning, Nagendra P. Palani, T. Pers, 2023, Nature Metabolism.

The human PINK1 locus is regulated in vivo by a non-coding natural antisense RNA during modulation of mitochondrial function

T. Lassmann, C. Wahlestedt, J. Timmons, 2007 .

Can we target obesity using a single-cell atlas of adipose tissue?

C. Schéele, Søren Nielsen, 2022, Med.

PRDM16 stability and metabolically healthy adipose tissue

C. Schéele, Carla Horváth, 2022, Nature Metabolism.

An anti-inflammatory phenotype in visceral adipose tissue of old lean mice, augmented by exercise

M. Kjaer, C. Schéele, P. Schjerling, 2019, Scientific Reports.

SUPPLEMENTARY MATERIAL AND METHODS

J. Nielsen, M. Uhlén, B. Pedersen, 2017 .

Brown Fat AKT2 Is a Cold-Induced Kinase that Stimulates ChREBP-Mediated De Novo Lipogenesis to Optimize Fuel Storage and Thermogenesis.

Christian M. Metallo, D. Guertin, C. Schéele, 2018, Cell metabolism.

The human PINK1 locus is regulated in vivo by a non-coding natural antisense RNA during modulation of mitochondrial function

T. Lassmann, C. Schéele, O. Rooyackers, 2007, BMC Genomics.

Osteogenesis depends on commissioning of a network of stem cell transcription factors that act as repressors of adipogenesis

Anders K. Haakonsson, J. Baumbach, S. Mandrup, 2019, Nature Genetics.

Perspectives on the role of brown adipose tissue in human body temperature and metabolism

C. Schéele, 2021, Cell Reports Medicine.