B. Monia

发表

Enhanced oxaliplatin-induced apoptosis following antisense Bcl-xl down-regulation is p53 and Bax dependent: Genetic evidence for specificity of the antisense effect.

R. L. Hayward, J. S. Macpherson, J. Cummings, 2004, Molecular cancer therapeutics.

PTEN, but not SHIP and SHIP2, suppresses the PI3K/Akt pathway and induces growth inhibition and apoptosis of myeloma cells

B. Monia, J. Gutkind, Y. Choi, 2002, Oncogene.

Comparison of strategies targeting Raf‐1 mRNA in ovarian cancer

B. Monia, J. Smyth, P. Mullen, 2006, International journal of cancer.

Raf-1 is the predominant Raf isoform that mediates growth factor-stimulated growth in ovarian cancer cells.

D. Cameron, B. Monia, J. Smyth, 2006, Carcinogenesis.

Reduced adiposity and improved insulin sensitivity in obese mice with antisense suppression of 4E-BP2 expression.

B. Monia, Xing Yu, S. Pandey, 2008, American journal of physiology. Endocrinology and metabolism.

Polyethyleneimine grafted with pluronic P85 enhances Ku86 antisense delivery and the ionizing radiation treatment efficacy in vivo

T. Chow, B. Monia, A. Belenkov, 2004, Gene Therapy.

Preclinical evaluation of the toxicological effects of a novel constrained ethyl modified antisense compound targeting signal transducer and activator of transcription 3 in mice and cynomolgus monkeys.

B. Monia, Shin-Young Park, S. Henry, 2013, Nucleic acid therapeutics.

Implication of RNA structure on antisense oligonucleotide hybridization kinetics.

D. Ecker, S. Freier, B. Monia, 1992, Biochemistry.

Antisense oligonucleotide therapy for TTR amyloidosis

M. Benson, B. Monia, B. Kluve-Beckerman, 2011, Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.

Characterization of target mRNA reduction through in situ RNA hybridization in multiple organ systems following systemic antisense treatment in animals.

Shuling Guo, B. Monia, D. Norris, 2013, Nucleic acid therapeutics.

Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary N-acetyl galactosamine improves potency 10-fold in mice

Shuling Guo, B. Monia, S. Booten, 2014, Nucleic acids research.

Inotersen Treatment for Patients with Hereditary Transthyretin Amyloidosis

S. Solomon, A. Shah, W. Litchy, 2018, The New England journal of medicine.

Novel mechanisms for antisense-mediated regulation of gene expression.

B. Monia, B. Baker, 1999, Biochimica et biophysica acta.

Role for Cela1 in Postnatal Lung Remodeling and Alpha‐1 Antitrypsin‐Deficient Emphysema

Shuling Guo, B. Monia, A. Weiss, 2018, American journal of respiratory cell and molecular biology.

Prevention of hepatic steatosis and hepatic insulin resistance by knockdown of cAMP response element-binding protein.

G. Shulman, G. Cline, B. Monia, 2009, Cell metabolism.

Deletion of individual exons and induction of soluble murine interleukin-5 receptor-alpha chain expression through antisense oligonucleotide-mediated redirection of pre-mRNA splicing.

J. Karras, B. Monia, N. Dean, 2000, Molecular pharmacology.

Antisense oligonucleotide-mediated Dnm2 knockdown prevents and reverts myotubular myopathy in mice

Shuling Guo, B. Monia, S. Booten, 2017, Nature Communications.

miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting.

Mark Graham, Susan F Murray, B. Monia, 2006, Cell metabolism.

Evaluation of 2'-modified oligonucleotides containing 2'-deoxy gaps as antisense inhibitors of gene expression.

P. D. Cook, E. Lesnik, S. Freier, 1993, The Journal of biological chemistry.

Bcl‐XL is a chemoresistance factor in human melanoma cells that can be inhibited by antisense therapy

H. Pehamberger, K. Wolff, B. Monia, 2002, International journal of cancer.

Loss of PTEN is associated with progression to androgen independence

M. Gleave, L. Fazli, J. Peacock, 2006, The Prostate.

AZD9150, a next-generation antisense oligonucleotide inhibitor of STAT3 with early evidence of clinical activity in lymphoma and lung cancer

J. Nemunaitis, R. Kurzrock, M. Jo, 2015, Science Translational Medicine.

PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients.

Ming Tan, Dihua Yu, Ping Li, 2004, Cancer cell.

Use of antisense oligonucleotides to correct the splicing error in ISCU myopathy patient cell lines.

Shuling Guo, B. Monia, R. Haller, 2016, Human molecular genetics.

Peripheral androgen receptor gene suppression rescues disease in mouse models of spinal and bulbar muscular atrophy.

Shuling Guo, B. Monia, Zhigang Yu, 2014, Cell reports.

Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis

S. McCall, B. Monia, Xing Yu, 2007, Hepatology.

Selective inhibition of mutant Ha-ras mRNA expression by antisense oligonucleotides.

D. Ecker, S. Freier, B. Monia, 1992, The Journal of biological chemistry.

2'-O-aminopropyl ribonucleotides: a zwitterionic modification that enhances the exonuclease resistance and biological activity of antisense oligonucleotides.

P. D. Cook, R. Griffey, E. Lesnik, 1996, Journal of medicinal chemistry.

Genetic diminution of circulating prothrombin ameliorates multiorgan pathologies in sickle cell disease mice.

J. Wansapura, B. Monia, T. Rizvi, 2015, Blood.

Protein Kinase C-ζ Mediates Angiotensin II Activation of ERK1/2 in Vascular Smooth Muscle Cells*

B. Monia, N. Dean, B. Berk, 1997, The Journal of Biological Chemistry.

Ligand conjugated antisense oligonucleotide for the treatment of transthyretin amyloidosis: preclinical and phase 1 data

M. Benson, Shuling Guo, B. Monia, 2020, ESC heart failure.

Inhibition of the alternative complement pathway by antisense oligonucleotides targeting complement factor B improves lupus nephritis in mice.

P. Adamson, B. Monia, S. Henry, 2016, Immunobiology.

A Role for c-Raf Kinase and Ha-Ras in Cytokine-mediated Induction of Cell Adhesion Molecules*

B. Monia, C. Bennett, Xiaoxin Xu, 1998, The Journal of Biological Chemistry.

Suppressing transthyretin production in mice, monkeys and humans using 2nd-Generation antisense oligonucleotides

M. Benson, Shuling Guo, B. Monia, 2016, Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.

In vivo suppression of Bcl‐XL expression facilitates chemotherapy‐induced leukaemia cell death in a SCID/NOD‐Hu model

D. Fennell, B. Monia, N. Dean, 2001, British journal of haematology.

Colon Cancer Growth and Dissemination Relies upon Thrombin, Stromal PAR-1, and Fibrinogen.

B. Monia, A. Revenko, M. Flick, 2015, Cancer research.

Hepatic and glucagon-like peptide-1-mediated reversal of diabetes by glucagon receptor antisense oligonucleotide inhibitors.

N. Porksen, J. Gromada, B. Berridge, 2004, The Journal of clinical investigation.

Prediction of antisense oligonucleotide efficacy by in vitro methods

J. F. Atkins, R. Gesteland, O. Matveeva, 1998, Nature Biotechnology.

Reduction in glucagon receptor expression by an antisense oligonucleotide ameliorates diabetic syndrome in db/db mice.

B. Monia, Pengxiang She, S. Bhanot, 2004, Diabetes.

Hepatic thrombopoietin gene silencing reduces platelet count and breast cancer progression in transgenic MMTV-PyMT mice.

Laura D. Healy, L. Coussens, O. McCarty, 2019, Blood advances.

An antisense oligonucleotide targeted to human Ku86 messenger RNA sensitizes M059K malignant glioma cells to ionizing radiation, bleomycin, and etoposide but not DNA cross-linking agents.

T. Chow, B. Monia, A. Belenkov, 2002, Cancer research.

Arterial thrombosis is accelerated in mice deficient in histidine-rich glycoprotein.

B. Monia, W. Jahnen-Dechent, J. Weitz, 2015, Blood.

Mcl-1 overexpression in hepatocellular carcinoma: a potential target for antisense therapy.

M. Peck-Radosavljevic, B. Monia, K. Schmid, 2006, Journal of hepatology.

Inhibition of Cell Growth by Antisense Oligonucleotides Targeting the Growth-Related Protein Kinase c-raf.

D. Fabbro, K. Altmann, B. Monia, 2000, Methods in molecular medicine.

Coagulation factor XI as a novel target for antithrombotic treatment

B. Monia, M. Levi, J. Meijers, 2010, Journal of thrombosis and haemostasis : JTH.

Second Generation of Antisense Oligonucleotides: From Nuclease Resistance to Biological Efficacy in Animals

S. Freier, D. Fabbro, F. Natt, 1996, CHIMIA.

Second-generation antisense oligonucleotides: structure-activity relationships and the design of improved signal-transduction inhibitors.

D. Fabbro, K. Altmann, B. Monia, 1996, Biochemical Society transactions.

Targeting Foxo1 in Mice Using Antisense Oligonucleotide Improves Hepatic and Peripheral Insulin Action

G. Shulman, J. Geisler, B. Monia, 2006, Diabetes.

Factor XI antisense oligonucleotide for prevention of venous thrombosis.

G. Raskob, H. Büller, B. Monia, 2014, The New England journal of medicine.

Bcl-xL Antisense Oligonucleotides Chemosensitize Human Glioblastoma Cells

H. Pehamberger, H. Eichler, B. Monia, 2002, Chemotherapy.

Evaluation of Therapeutic Oligonucleotides for Familial Amyloid Polyneuropathy in Patient-Derived Hepatocyte-Like Cells

Shuling Guo, B. Monia, J. Gollob, 2016, PloS one.

Mcl-1 Is a Novel Therapeutic Target for Human Sarcoma

H. Pehamberger, B. Monia, M. Wolschek, 2004, Clinical Cancer Research.

Inhibition of the intrinsic coagulation pathway factor XI by antisense oligonucleotides: a novel antithrombotic strategy with lowered bleeding risk.

B. Monia, E. Stroes, M. Levi, 2010, Blood.

Antisense oligonucleotide treatment ameliorates IFN-γ-induced proteinuria in APOL1-transgenic mice.

Christopher E. Hart, S. Kuntz, Shuling Guo, 2019, JCI insight.

Inhibition of protein kinase Cε prevents hepatic insulin resistance in nonalcoholic fatty liver disease

G. Shulman, J. Geisler, B. Monia, 2007 .

Thrombin drives tumorigenesis in colitis-associated colon cancer.

D. Witte, B. Monia, E. Mullins, 2014, Cancer research.

Antisense inhibition of membrane-bound human interleukin-5 receptor-alpha chain does not affect soluble receptor expression and induces apoptosis in TF-1 cells.

J. Karras, B. Monia, N. Dean, 2000, Antisense & nucleic acid drug development.

Disruption of WT1 gene expression and exon 5 splicing following cytotoxic drug treatment: antisense down-regulation of exon 5 alters target gene expression and inhibits cell survival.

R. Williams, P. Workman, M. Walton, 2004, Molecular cancer therapeutics.

Interleukin‐2 family cytokines stimulate phosphorylation of the Pro‐Ser‐Pro motif of Stat5 transcription factors in human T cells: resistance to suppression of multiple serine kinase pathways

H. Rui, B. Monia, Yuling Wang, 2002, Journal of leukocyte biology.

Nuclease Resistance and Antisense Activity of Modified Oligonucleotides Targeted to Ha-ras*

B. Monia, L. Cummins, H. Sasmor, 1996, The Journal of Biological Chemistry.

Antisense knockdown of Kras inhibits fibrosis in a rat model of unilateral ureteric obstruction.

B. Hendry, B. Monia, Jia-hui Wang, 2012, The American journal of pathology.

Role of Ras isoforms in the stimulated proliferation of human renal fibroblasts in primary culture.

B. Hendry, B. Monia, M. Dockrell, 2000, Journal of the American Society of Nephrology : JASN.

An oral antisense oligonucleotide for PCSK9 inhibition

P. Gennemark, B. Monia, M. Hölttä, 2021, Science Translational Medicine.

Thrombomodulin is a determinant of metastasis through a mechanism linked to the thrombin binding domain but not the lectin-like domain.

B. Monia, C. Spek, K. Queiroz, 2011, Blood.

In Vitro and In Vivo Effects of SerpinA1 on the Modulation of Transthyretin Proteolysis

Shuling Guo, B. Monia, M. Saraiva, 2021, International journal of molecular sciences.

Role of resistin in diet-induced hepatic insulin resistance.

B. Monia, E. D. Muse, L. Rossetti, 2004, The Journal of clinical investigation.

Mcl-1 antisense therapy chemosensitizes human melanoma in a SCID mouse xenotransplantation model.

H. Pehamberger, K. Wolff, B. Monia, 2003, The Journal of investigative dermatology.

Specific inhibition of PTEN expression reverses hyperglycemia in diabetic mice.

B. Monia, N. Dean, S. Murray, 2002, Diabetes.

The role of peroxisome proliferator-activated receptor gamma coactivator-1 beta in the pathogenesis of fructose-induced insulin resistance.

G. Shulman, B. Monia, D. Weismann, 2009, Cell metabolism.

Reduction of hepatic and adipose tissue glucocorticoid receptor expression with antisense oligonucleotides improves hyperglycemia and hyperlipidemia in diabetic rodents without causing systemic glucocorticoid antagonism.

B. Monia, S. Bhanot, M. Michael, 2005, Diabetes.

SERPINA1 modulates expression of amyloidogenic transthyretin.

Shuling Guo, B. Monia, M. Saraiva, 2020, Experimental cell research.

Evaluation of biological role of c-Jun N-terminal kinase using an antisense approach.

B. Monia, C. Cioffi, 2000, Methods in enzymology.

Suppression of Diacylglycerol Acyltransferase-2 (DGAT2), but Not DGAT1, with Antisense Oligonucleotides Reverses Diet-induced Hepatic Steatosis and Insulin Resistance*

G. Shulman, J. Geisler, G. Cline, 2007, Journal of Biological Chemistry.

Antisense oligonucleotide reduction of DGAT2 expression improves hepatic steatosis and hyperlipidemia in obese mice

B. Monia, Xing Yu, S. Pandey, 2005, Hepatology.

Role of Chymotrypsin-like Elastase 1 in Lung Physiology and in α1-Antitrypsin Deficiency

Shuling Guo, B. Monia, A. Weiss, 2017, bioRxiv.

Gene synthesis, expression, and processing of human ubiquitin carboxyl extension proteins.

D. Ecker, T. Butt, B. Monia, 1989, The Journal of biological chemistry.

Inhibition of protein kinase Cepsilon prevents hepatic insulin resistance in nonalcoholic fatty liver disease.

G. Shulman, J. Geisler, B. Monia, 2007, The Journal of clinical investigation.

Deficiency of adiponectin receptor 2 reduces diet-induced insulin resistance but promotes type 2 diabetes.

S. Kash, B. Monia, S. Murray, 2007, Endocrinology.

Characterization and modulation of immune stimulation by modified oligonucleotides.

B. Monia, C. Bennett, T. Condon, 1997, Antisense & nucleic acid drug development.

Antisense Oligonucleotides to poly(ADP-ribose) Polymerase-2 Ameliorate Colitis in Interleukin-10-Deficient Mice

B. Monia, K. Madsen, M. Tavernini, 2002, Journal of Pharmacology and Experimental Therapeutics.

Transthyretin Antisense Oligonucleotides Lower Circulating RBP4 Levels and Improve Insulin Sensitivity in Obese Mice

Shuling Guo, B. Monia, B. Kahn, 2014, Diabetes.

Inhibition of c-Jun N-terminal kinase 1, but not c-Jun N-terminal kinase 2, suppresses apoptosis induced by ischemia/reoxygenation in rat cardiac myocytes.

B. Monia, C. Cioffi, R. Mckay, 2001, Molecular pharmacology.

Evidence of a role for Ki-Ras in the stimulated proliferation of renal fibroblasts.

B. Hendry, B. Monia, M. Dockrell, 1999, Journal of the American Society of Nephrology : JASN.

Specific Reduction of Hepatic Glucose 6-Phosphate Transporter-1 Ameliorates Diabetes while Avoiding Complications of Glycogen Storage Disease*

B. Monia, S. Booten, S. Murray, 2007, Journal of Biological Chemistry.

Mcl-1 blocks radiation-induced apoptosis and inhibits clonogenic cell death.

H. Pehamberger, B. Monia, C. Thallinger, 2005, Anticancer research.

Inhibition of Antigen-Induced Eosinophilia and Late Phase Airway Hyperresponsiveness by an IL-5 Antisense Oligonucleotide in Mouse Models of Asthma

J. Karras, B. Monia, N. Dean, 2000, The Journal of Immunology.

Mouse Models of Asthma by an IL-5 Antisense Oligonucleotide in and Late Phase Airway Hyperresponsiveness Inhibition of Antigen-Induced Eosinophilia

J. Karras, B. Monia, N. Dean, 2000 .

Regulation of Lipoprotein Lipase by Protein Kinase Cα in 3T3-F442A Adipocytes*

S. Barger, B. Monia, N. Dean, 2002, The Journal of Biological Chemistry.

Severe impairment in liver insulin signaling fails to alter hepatic insulin action in conscious mice.

B. Monia, E. D. Muse, L. Rossetti, 2005, The Journal of clinical investigation.

Peripheral Reduction of FGFR4 with Antisense Oligonucleotides Increases Metabolic Rate and Lowers Adiposity in Diet-Induced Obese Mice

B. Monia, Xing Yu, S. Bhanot, 2013, PloS one.

Protein tyrosine phosphatase 1B reduction regulates adiposity and expression of genes involved in lipogenesis.

J. Waring, R. Ulrich, B. Monia, 2002, Diabetes.

Protein Tyrosine Phosphatase 1B Reduction Regulates Adiposity and Expression of Genes Involved in

J. Waring, R. Ulrich, B. Monia, 2002 .

Pharmacological Activity of Antisense Oligonucleotides in Animal Models of Disease

B. Monia, N. Dean, 1998 .

Underlying Immune Disorder May Predispose Some Transthyretin Amyloidosis Subjects to Inotersen-Mediated Thrombocytopenia.

B. Monia, S. Henry, T. Machemer, 2020, Nucleic acid therapeutics.

Exposure of human vascular smooth muscle cells to Raf-1 antisense oligodeoxynucleotides: cellular responses and pharmacodynamic implications.

L. Wennogle, B. Monia, C. Cioffi, 1998, Molecular pharmacology.

Pharmacology of antisense therapeutic agents : cancer and inflamination.

D. Ecker, B. Monia, N. Dean, 1996, Methods in molecular medicine.

Elucidating cell signaling mechanisms using antisense technology.

B. Monia, E. Koller, W. Gaarde, 2000, Trends in pharmacological sciences.

Using antisense technology to develop a novel therapy for α-1 antitrypsin deficient (AATD) liver disease and to model AATD lung disease

Shuling Guo, B. Monia, S. Booten, 2014, Rare diseases.

Toward antisense oligonucleotide therapy for cancer: ISIS compounds in clinical development.

B. Monia, J. Holmlund, F. A. Dorr, 1999, Current opinion in molecular therapeutics.

Peptide nucleic acids conjugated to short basic peptides show improved pharmacokinetics and antisense activity in adipose tissue.

R. Griffey, D. Corey, B. Monia, 2010, Journal of medicinal chemistry.

Antisense oligonucleotides targeted against glucocorticoid receptor reduce hepatic glucose production and ameliorate hyperglycemia in diabetic mice.

B. Monia, Pengxiang She, S. Bhanot, 2005, Metabolism: clinical and experimental.

Regulation of 5-lipoxygenase and 5-lipoxygenase-activating protein expression in HL-60 cells.

B. Monia, S. Crooke, C. Bennett, 1993, The Biochemical journal.

In Vitro and In Vivo Inhibition of Interleukin (IL)-5–Mediated Eosinopoiesis by Murine IL-5R α Antisense Oligonucleotide

J. Karras, B. Monia, C. Walker, 2001 .

Selective killing of cancer cells based on loss of heterozygosity and normal variation in the human genome: a new paradigm for anticancer drug therapy.

D. Housman, J. Basilion, V. Stanton, 1999, Molecular pharmacology.

New Perspectives on the Structure and Function of Ubiquitin

D. Ecker, B. Monia, S. Crooke, 1990, Bio/Technology.

Studies on the Structure and Function of Ubiquitin

D. Ecker, L. Mueller, F. Brown, 1990 .

Antisense oligonucleotide treatment ameliorates alpha-1 antitrypsin-related liver disease in mice.

Shuling Guo, B. Monia, S. Booten, 2014, The Journal of clinical investigation.

Antithrombotic Effect of Antisense Factor XI Oligonucleotide Treatment in Primates

A. Gruber, S. Hanson, B. Monia, 2013, Arteriosclerosis, thrombosis, and vascular biology.

Antisense inhibition of coagulation factor XI prolongs APTT without increased bleeding risk in cynomolgus monkeys.

B. Monia, S. Henry, J. Huh, 2012, Blood.

Sex-specific differences in emphysema using a murine antisense oligonucleotide model of α-1 antitrypsin deficiency.

Shuling Guo, B. Monia, R. Joshi, 2019, American journal of physiology. Lung cellular and molecular physiology.

Knockdown of Z Mutant Alpha-1 Antitrypsin In Vivo Using Modified DNA Antisense Oligonucleotides.

Shuling Guo, B. Monia, M. Aghajan, 2017, Methods in molecular biology.

Antisense raf oligodeoxyribonucleotide is a radiosensitizer in vivo.

A. Bagg, A. Dritschilo, B. Monia, 1999, Antisense & nucleic acid drug development.

Inhaled CD86 Antisense Oligonucleotide Suppresses Pulmonary Inflammation and Airway Hyper-Responsiveness in Allergic Mice

J. Karras, B. Monia, R. Geary, 2007, Journal of Pharmacology and Experimental Therapeutics.

Anti-Inflammatory Activity of Inhaled IL-4 Receptor-α Antisense Oligonucleotide in Mice

J. Karras, B. Monia, R. Geary, 2007 .

Anti-inflammatory activity of inhaled IL-4 receptor-alpha antisense oligonucleotide in mice.

J. Karras, B. Monia, R. Geary, 2007, American journal of respiratory cell and molecular biology.

Bcl-2 sustains increased mucous and epithelial cell numbers in metaplastic airway epithelium.

S. Randell, J. Hotchkiss, Y. Tesfaigzi, 2005, American journal of respiratory and critical care medicine.

Antisense oligonucleotide suppression of serum amyloid A reduces amyloid deposition in mice with AA amyloidosis

M. Benson, B. Monia, R. Crooke, 2011, Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.

Antisense Oligonucleotides Targeting Jagged 1 Reduce House Dust Mite-Induced Goblet Cell Metaplasia in the Adult Murine Lung.

Christopher E. Hart, B. Monia, Guizhen Sun, 2020, American journal of respiratory cell and molecular biology.

Nonsense Mediated RNA Decay Pathway Inhibition Restores Expression and Function of W1282X CFTR.

Shuling Guo, B. Monia, H. Bihler, 2019, American journal of respiratory cell and molecular biology.

The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and -2

H. Askari, J. Geisler, M. Connelly, 2012, Journal of Lipid Research.

Mcl-1 is a relevant molecular target for antisense oligonucleotide strategies in gastric cancer cells

B. Monia, V. Wacheck, R. Crevenna, 2006, Cancer biology & therapy.

Preclinical Development Transcription Factor Stat 5 Knockdown Enhances Androgen Receptor Degradation and Delays Castration-Resistant Prostate Cancer Progression In vivo

M. Gleave, A. Zoubeidi, L. Fazli, 2011 .

Antitumor activity of a C-raf antisense oligonucleotide in combination with standard chemotherapeutic agents against various human tumors transplanted subcutaneously into nude mice.

D. Fabbro, B. Monia, M. Müller, 1997, Clinical cancer research : an official journal of the American Association for Cancer Research.

Diacylglycerol acyltranferase 1 anti‐sense oligonucleotides reduce hepatic fibrosis in mice with nonalcoholic steatohepatitis

S. McCall, B. Monia, Xing Yu, 2007, Hepatology.

Results Inhibition of FXI With aXIMab : Effects on Thrombosis in the Baboon Model

A. Gruber, S. Hanson, B. Monia, 2013 .

THROMBOSIS AND HEMOSTASIS Arterial thrombosis is accelerated in mice de ﬁ cient in histidine-rich glycoprotein

B. Monia, W. Jahnen-Dechent, J. Weitz, 2015 .

Arterial thrombosis is accelerated in histidine-rich glycoprotein deficient mice

B. Monia, W. Jahnen-Dechent, J. Weitz, 2015 .

Antitumor activity of antisense clusterin oligonucleotides is improved in vitro and in vivo by incorporation of 2'-O-(2-methoxy)ethyl chemistry.

M. Gleave, H. Miyake, B. Monia, 2001, The Journal of pharmacology and experimental therapeutics.

oligonucleotide in a subset of patients with heavily pretreated lymphoma: results of a phase 1b trial.

J. Nemunaitis, R. Kurzrock, M. Jo, 2018 .

Antisense strategy shows that Mcl-1 rather than Bcl-2 or Bcl-x(L) is an essential survival protein of human myeloma cells.

R. Bataille, M. Amiot, B. Monia, 2002, Blood.

Antisense oligonucleotide targeting of insulin‐like growth factor‐1 receptor (IGF‐1R) in prostate cancer

S. Freier, M. Gleave, B. Monia, 2010, The Prostate.

Suppression of choroid plexus transthyretin levels by antisense oligonucleotide treatment

M. Benson, B. Monia, B. Kluve-Beckerman, 2010, Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.

Preclinical evaluation of the effects of a novel antisense compound targeting C-raf kinase in mice and monkeys.

B. Monia, A. Levin, R. Geary, 1998, Toxicological sciences : an official journal of the Society of Toxicology.

Targeting Translation Termination Machinery with Antisense Oligonucleotides for Diseases Caused by Nonsense Mutations

Shuling Guo, B. Monia, S. Murray, 2019, Nucleic acid therapeutics.

Inhibiting gene expression with locked nucleic acids (LNAs) that target chromosomal DNA.

D. Corey, B. Monia, K. Arar, 2007, Biochemistry.

Metallothionein turnover in mammalian cells. Implications in metal toxicity.

D. Ecker, T. Butt, B. Monia, 1986, The Journal of biological chemistry.

Clinical development of an antisense therapy for the treatment of transthyretin-associated polyneuropathy

M. Benson, Shuling Guo, B. Monia, 2012, Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.

Leukotriene Receptors and Mechanisms of Signal Transduction

C. F. Bennett, B. Monia, S. Crooke, 1991, Annals of the New York Academy of Sciences.

Telomerase reverse transcriptase (hTERT) mRNA and telomerase RNA (hTR) as targets for downregulation of telomerase activity.

D. Corey, B. Monia, E. Wancewicz, 2004, Oligonucleotides.

Inhibition of telomerase by 2'-O-(2-methoxyethyl) RNA oligomers: effect of length, phosphorothioate substitution and time inside cells.

D. Corey, B. Monia, A. Elayadi, 2001, Nucleic acids research.

Molecular and cellular characterization of baboon C-Raf as a target for antiproliferative effects of antisense oligonucleotides.

A. Yuryev, L. Wennogle, S. Hanson, 1997, Antisense & nucleic acid drug development.

Protein kinase C-zeta mediates angiotensin II activation of ERK1/2 in vascular smooth muscle cells.

B. Monia, N. Dean, B. Berk, 1997, The Journal of biological chemistry.

Patent Number : ( 45 ) Date of Patent : 5 , 576 , 208 Nov . 19 , 1996

D. Ecker, B. Monia, 2017 .

Design and Rationale of the Global Phase 3 NEURO-TTRansform Study of Antisense Oligonucleotide AKCEA-TTR-LRx (ION-682884-CS3) in Hereditary Transthyretin-Mediated Amyloid Polyneuropathy

W. Litchy, M. Benson, P. Dyck, 2021, Neurology and Therapy.

Bcl-xL antisense oligonucleotides radiosensitise colon cancer cells

B. Monia, C. Thallinger, T. Lucas, 2003, British Journal of Cancer.

Inhibition of progression to androgen‐independence by combined adjuvant treatment with antisense BCL‐XL and antisense Bcl‐2 oligonucleotides plus taxol after castration in the Shionogi tumor model

M. Gleave, H. Miyake, B. Monia, 2000, International journal of cancer.

Inhaled ENaC antisense oligonucleotide ameliorates cystic fibrosis-like lung disease in mice.

Shuling Guo, B. Monia, D. Rotin, 2017, Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.

Gene synthesis, expression, structures, and functional activities of site-specific mutants of ubiquitin.

D. Ecker, L. Mueller, T. Butt, 1987, The Journal of biological chemistry.

Inhibition of spinal cytosolic phospholipase A2 expression by an antisense oligonucleotide attenuates tissue injury-induced hyperalgesia

D. H. Kim, C. Svensson, B. Monia, 2008, Neuroscience.

Reversing Antisense Oligonucleotide Activity with a Sense Oligonucleotide Antidote: Proof of Concept Targeting Prothrombin.

Shuling Guo, B. Monia, A. Macleod, 2015, Nucleic acid therapeutics.

Structure-activity relationship study on a simple cationic peptide motif for cellular delivery of antisense peptide nucleic acid.

R. Griffey, M. Manoharan, B. Monia, 2005, Journal of Medicinal Chemistry.

Identification and functional validation of PNAs that inhibit murine CD40 expression by redirection of splicing.

B. Monia, C. Bennett, M. Maier, 2004, Nucleic acids research.

Translational regulation of lipoprotein lipase in adipocytes: depletion of cellular protein kinase Calpha activates binding of the C subunit of protein kinase A to the 3'-untranslated region of the lipoprotein lipase mRNA.

B. Monia, P. Kern, P. Tripathi, 2008, The Biochemical journal.

Remarkable Enhancement of Binding Affinity of Heterocycle-Modified DNA to DNA and RNA. Synthesis, Characterization and Biophysical Evaluation of N2-Imidazolylpropylguanine and N2-Imidazolylpropyl-2-aminoadenine Modified Oligonucleotides.

P. D. Cook, R. Griffey, E. Lesnik, 1994 .

Intravitreous anti-raf-1 kinase antisense oligonucleotide as an angioinhibitory agent in porcine preretinal neovascularization

F. Orge, R. Danis, K. Stecker, 2003, Current eye research.

Antisense oligonucleotide targeting of mRNAs encoding ENaC subunits α, β, and γ improves cystic fibrosis-like disease in mice.

Shuling Guo, B. Monia, D. Bai, 2019, Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.

Cross-Linking Agents Ionizing Radiation , Bleomycin , and Etoposide but not DNA Messenger RNA Sensitizes M 059 K Malignant Glioma Cells to An Antisense Oligonucleotide Targeted to Human Ku 86 Updated

T. Chow, B. Monia, A. Belenkov, 2002 .

thrombosis in mice without increased risk of bleeding Selective depletion of plasma prekallikrein or coagulation factor XII inhibits

B. Monia, G. Bhattacharjee, Chenguang Zhao, 2012 .

Selective depletion of factor XI or factor XII with antisense oligonucleotides attenuates catheter thrombosis in rabbits.

B. Monia, J. Weitz, A. Revenko, 2014, Blood.

Reducing dynamin 2 (DNM2) rescues DNM2-related dominant centronuclear myopathy

Shuling Guo, B. Monia, J. Matson, 2018, Proceedings of the National Academy of Sciences.

Comparing in vitro and in vivo activity of 2'-O-[2-(methylamino)-2-oxoethyl]- and 2'-O-methoxyethyl-modified antisense oligonucleotides.

M. Manoharan, B. Monia, A. M. Kawasaki, 2008, Journal of medicinal chemistry.

Combination of Tmprss6- ASO and the iron chelator deferiprone improves erythropoiesis and reduces iron overload in a mouse model of beta-thalassemia intermedia

S. Rivella, Shuling Guo, B. Monia, 2016, Haematologica.

Sequence-specific antitumor activity of a phosphorothioate oligodeoxyribonucleotide targeted to human C-raf kinase supports an antisense mechanism of action in vivo.

E. Lesnik, S. Freier, D. Fabbro, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Antisense Oligonucleotides Demonstrate a Dominant Role of c-Ki-RAS Proteins in Regulating the Proliferation of Diploid Human Fibroblasts*

B. Monia, D. Stacey, Guan Chen, 1996, The Journal of Biological Chemistry.

PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice

J. Waring, R. Ulrich, S. Crosby, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Evaluation of C-5 propynyl pyrimidine-containing oligonucleotides in vitro and in vivo.

E. Lesnik, M. Manoharan, B. Monia, 2003, Antisense & nucleic acid drug development.

Therapeutic potential for microRNAs.

B. Monia, C. Esau, Christine Esau, 2007, Advanced drug delivery reviews.

Inhibition of focal adhesion kinase expression or activity disrupts epidermal growth factor-stimulated signaling promoting the migration of invasive human carcinoma cells.

D. Schlaepfer, B. Monia, C. Hauck, 2001, Cancer research.

Antisense Oligonucleotide Targeting of Raf-1

B. Monia, J. Smyth, P. Mullen, 2004, Clinical Cancer Research.

Relaxin positively regulates matrix metalloproteinase expression in human lower uterine segment fibroblasts using a tyrosine kinase signaling pathway.

B. Monia, L. Goldsmith, G. Weiss, 2001, Endocrinology.

Antisense Research and Application

G. Schultz, P. Nielsen, R. Zhang, 1998, Handbook of Experimental Pharmacology.

Biophysical and antisense properties of oligodeoxynucleotides containing 7-propynyl-, 7-iodo- and 7-cyano-7-deaza-2-amino-2'-deoxyadenosines.

E. Lesnik, B. Monia, J. Johnston, 1998, Nucleic acids research.

Discovery and analysis of antisense oligonucleotide activity in cell culture.

B. Monia, E. Koller, B. Baker, 2001, Methods.

Synthesis, Biophysical and Biological Evaluations of Novel Antisense Oligonucleosides Containing Dephosphono-Internucleosidic Linkages

P. D. Cook, R. Griffey, S. Freier, 1995 .

Inhibition of hypoxia/reoxygenation-induced apoptosis by an antisense oligonucleotide targeted to JNK1 in human kidney cells.

B. Monia, C. Cioffi, W. Gaarde, 2000, Biochemical pharmacology.

Kinetic characteristics of Escherichia coli RNase H1: cleavage of various antisense oligonucleotide-RNA duplexes.

R. Griffey, E. Lesnik, B. Monia, 1995, The Biochemical journal.

TMPRSS6 as a Therapeutic Target for Disorders of Erythropoiesis and Iron Homeostasis

S. Rivella, Paul W Goldberg, T. Ganz, 2023, Advances in Therapy.

Reducing TMPRSS6 ameliorates hemochromatosis and β-thalassemia in mice.

S. Rivella, Shuling Guo, B. Monia, 2013, The Journal of clinical investigation.

Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals

B. Monia, A. Siwkowski, G. Hung, 2006, Nucleic acids research.

Antisense oligodeoxynucleotides for urokinase‐plasminogen activator receptor have anti‐invasive and anti‐proliferative effects in vitro and inhibit spontaneous metastases of human melanoma in mice

C. Leonetti, M. Scarsella, G. Zupi, 2004, International journal of cancer.

Phase I clinical/pharmacokinetic and pharmacodynamic trial of the c-raf-1 antisense oligonucleotide ISIS 5132 (CGP 69846A).

P. O'dwyer, K. Yao, B. Monia, 1999, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Remarkable enhancement of binding affinity of Heterocycle-modified DNA to DNA and RNA. Synthesis, characterization and biophysical evaluation of N2-imidazolylpropylguanine and N2-imidazolylpropyl-2-aminoadenine modified oligonucleotides

P. D. Cook, R. Griffey, E. Lesnik, 1994 .

Anti-tumor activity of C-raf antisense—correction

B. Monia, Brett P. Monia, 1999, Nature Medicine.

c-raf-1 depletion and tumor responses in patients treated with the c-raf-1 antisense oligodeoxynucleotide ISIS 5132 (CGP 69846A).

P. O'dwyer, K. Yao, B. Monia, 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.

Partial Hepatectomy Induced Long Noncoding RNA Inhibits Hepatocyte Proliferation during Liver Regeneration

Christopher E. Hart, S. Freier, M. Sabripour, 2015, PloS one.

Genomic Analysis of wig-1 Pathways

M. Sabripour, B. Monia, G. Hung, 2012, PloS one.

Steric Inhibition of 5′ UTR Regulatory Elements Results in Upregulation of Human CFTR

H. Bui, Shuling Guo, B. Monia, 2019, Molecular therapy : the journal of the American Society of Gene Therapy.

Identification of mcl-1 as a BCR/ABL-dependent target in chronic myeloid leukemia (CML): evidence for cooperative antileukemic effects of imatinib and mcl-1 antisense oligonucleotides.

S. Derdak, W. Pickl, R. Moriggl, 2005, Blood.

Antisense transcripts are targets for activating small RNAs

D. Corey, S. Younger, B. Monia, 2008, Nature Structural &Molecular Biology.

Selective depletion of plasma prekallikrein or coagulation factor XII inhibits thrombosis in mice without increased risk of bleeding.

B. Monia, C. May, A. Macleod, 2011, Blood.

Antisense Approaches for the Treatment of Cancer

B. Monia, J. Holmlund, F. A. Dorr, 2000, Cancer investigation.

Generation 2.5 Antisense Oligonucleotides Targeting the Androgen Receptor and Its Splice Variants Suppress Enzalutamide-Resistant Prostate Cancer Cell Growth

C. Collins, M. Gleave, A. Wyatt, 2015, Clinical Cancer Research.

Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia.

J. Downing, C. Murre, B. Monia, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Allele-Specific Inhibition of Rhodopsin With an Antisense Oligonucleotide Slows Photoreceptor Cell Degeneration.

M. Lavail, P. Adamson, Shuling Guo, 2015, Investigative ophthalmology & visual science.

Multiple (alpha-NH-ubiquitin)protein endoproteases in cells.

D. Ecker, T. Butt, B. Monia, 1989, The Journal of biological chemistry.

Antisense suppression of the nonsense mediated decay factor Upf3b as a potential treatment for diseases caused by nonsense mutations

Shuling Guo, B. Monia, S. Murray, 2018, Genome Biology.

Identification of REST-regulated genes and pathways using a REST-targeted antisense approach.

H. Bui, B. Monia, C. Mazur, 2013, Nucleic acid therapeutics.

Inhibition of hepatic endothelial E-selectin expression by C-raf antisense oligonucleotides blocks colorectal carcinoma liver metastasis.

B. Monia, P. Brodt, A. Khatib, 2002, Cancer research.

Destabilization of Raf-1 by geldanamycin leads to disruption of the Raf-1-MEK-mitogen-activated protein kinase signalling pathway

L. Neckers, M. Blagosklonny, P. Nguyen, 1996, Molecular and cellular biology.

Targeting KRAS-dependent tumors with AZD4785, a high-affinity therapeutic antisense oligonucleotide inhibitor of KRAS

P. Lyne, B. Monia, D. Blakey, 2017, Science Translational Medicine.

Antisense Bcl-xl down-regulation switches the response to topoisomerase I inhibition from senescence to apoptosis in colorectal cancer cells, enhancing global cytotoxicity.

R. L. Hayward, J. S. Macpherson, J. Cummings, 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

Transcription Factor Stat5 Knockdown Enhances Androgen Receptor Degradation and Delays Castration-Resistant Prostate Cancer Progression In vivo

M. Gleave, A. Zoubeidi, L. Fazli, 2011, Molecular Cancer Therapeutics.

Targeted delivery of antisense oligonucleotides to pancreatic β-cells

C. Ämmälä, B. Monia, E. Valeur, 2018, Science Advances.

Antisense oligonucleotide therapy for neurodegenerative disease.

B. Monia, C. Bennett, D. Cleveland, 2006, The Journal of clinical investigation.

Inhibition of proteolysis and cell cycle progression in a multiubiquitination-deficient yeast mutant

D. Ecker, D. Finley, V. Chau, 1994, Molecular and Cellular Biology.

STAT3 antisense oligonucleotide AZD9150 in a subset of patients with heavily pretreated lymphoma: results of a phase 1b trial.

J. Nemunaitis, R. Kurzrock, M. Jo, 2018, Journal of Immunotherapy for Cancer.

Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity

Alexander S. Banks, P. Puigserver, L. Alhonen, 2014, Nature.

Phase I Trial of ISIS 5132, an antisense oligonucleotide inhibitor of c-raf-1, administered by 24-hour weekly infusion to patients with advanced cancer.

C. Rudin, M. Ratain, B. Monia, 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.

Regulation of lipoprotein lipase by protein kinase C alpha in 3T3-F442A adipocytes.

S. Barger, B. Monia, N. Dean, 2002, The Journal of biological chemistry.

IONIS-PKKRx a Novel Antisense Inhibitor of Prekallikrein and Bradykinin Production

B. Monia, B. Baker, A. Macleod, 2019, Nucleic acid therapeutics.

Inhibition of vascular permeability by antisense-mediated inhibition of plasma kallikrein and coagulation factor 12.

B. Monia, C. May, A. Macleod, 2013, Nucleic acid therapeutics.

STAT3 regulates the growth and immunoglobulin production of BCL(1) B cell lymphoma through control of cell cycle progression.

J. Karras, B. Monia, T. Lu, 2000, Cellular immunology.

Combination of Tmprss6-ASO and the Iron Chelator Deferiprone Improves Erythropoiesis and Reduces Iron Overload in a Mouse Model of Beta-Thalassemia

S. Rivella, Shuling Guo, B. Monia, 2014 .

Pharmacological targeting of coagulation factor XI mitigates the development of experimental atherosclerosis in low‐density lipoprotein receptor‐deficient mice

O. McCarty, A. Gruber, M. Hinds, 2021, Journal of thrombosis and haemostasis : JTH.

Effect of focal adhesion kinase (FAK) downregulation with FAK antisense oligonucleotides and 5-fluorouracil on the viability of melanoma cell lines

V. Golubovskaya, W. Cance, B. Monia, 2005, Melanoma research.

A Phase I trial of h‐ras antisense oligonucleotide ISIS 2503 administered as a continuous intravenous infusion in patients with advanced carcinoma

J. Nemunaitis, B. Monia, A. Dorr, 2001, Cancer.

Platelet-localized FXI promotes a vascular coagulation-inflammatory circuit in arterial hypertension

T. Renné, U. Walter, A. Gruber, 2017, Science Translational Medicine.

Selective down-regulation of glioma-associated oncogene 2 inhibits the proliferation of hepatocellular carcinoma cells.

B. Monia, N. Dean, Youngsoo Kim, 2007, Cancer research.

First- and second-generation antisense oligonucleotide inhibitors targeted against human c-raf kinase.

B. Monia, 1997, Ciba Foundation symposium.

Critical role of stearoyl-CoA desaturase-1 (SCD1) in the onset of diet-induced hepatic insulin resistance.

B. Monia, Hiraku Ono, A. Pocai, 2006, The Journal of clinical investigation.

Reduction of Low Molecular Weight Protein-tyrosine Phosphatase Expression Improves Hyperglycemia and Insulin Sensitivity in Obese Mice*

B. Monia, Xing Yu, S. Pandey, 2007, Journal of Biological Chemistry.

Target TMPRSS6 for the Treatment of Hereditary Hemochromatosis

Shuling Guo, B. Monia, S. Booten, 2011 .

Thrombin signaling promotes pancreatic adenocarcinoma through PAR-1-dependent immune evasion.

B. Monia, E. Janssen, S. F. Konieczny, 2019, Cancer research.

Effects of antisense oligonucleotide-mediated depletion of tumor necrosis factor (TNF) receptor 1-associated death domain protein on TNF-induced gene expression.

J. Pober, B. Monia, L. Madge, 2004, Molecular pharmacology.

Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2.

G. Shulman, J. Geisler, G. Cline, 2006, The Journal of clinical investigation.

Inhibition of protein tyrosine phosphatase-1B with antisense oligonucleotides improves insulin sensitivity and increases adiponectin concentrations in monkeys.

B. Monia, S. Booten, S. Murray, 2009, Endocrinology.

Reversal of cisplatin resistance in human ovarian cancer cell lines by a c-jun antisense oligodeoxynucleotide (ISIS 10582): evidence for the role of transcription factor overexpression in determining resistant phenotype.

P. O'dwyer, K. Yao, B. Monia, 2002, Biochemical pharmacology.

CFTR mRNAs with nonsense codons are degraded by the SMG6-mediated endonucleolytic decay pathway

Shuling Guo, B. Monia, A. Revenko, 2022, Nature Communications.

SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats

M. Gillum, T. Horvath, G. Shulman, 2009, Proceedings of the National Academy of Sciences.

Navigating the Future of Cardiovascular Drug Development—Leveraging Novel Approaches to Drive Innovation and Drug Discovery: Summary of Findings from the Novel Cardiovascular Therapeutics Conference

S. Solomon, K. Mahaffey, T. Povsic, 2017, Cardiovascular Drugs and Therapy.

Reduction in ocular complement factor B protein in mice and monkeys by systemic administration of factor B antisense oligonucleotide

B. Monia, S. Henry, T. R. Grossman, 2016, Molecular vision.

Association of c-Raf expression with survival and its targeting with antisense oligonucleotides in ovarian cancer

B. Monia, J. Smyth, P. Mullen, 2001 .

Selective inhibition of A-Raf and C-Raf mRNA expression by antisense oligodeoxynucleotides in rat vascular smooth muscle cells: role of A-Raf and C-Raf in serum-induced proliferation.

B. Monia, C. Cioffi, D. Hreniuk, 1997, Molecular pharmacology.

Distinct roles of JNKs/p38 MAP kinase and ERKs in apoptosis and survival of HCD-57 cells induced by withdrawal or addition of erythropoietin.

J. Price, B. Monia, S. Krantz, 1999, Blood.

Mitogen-activated Protein (MAP) Kinase Is Regulated by the MAP Kinase Phosphatase (MKP-1) in Vascular Smooth Muscle Cells

B. Monia, B. Berk, J. L. Duff, 1995, The Journal of Biological Chemistry.

Transmembrane Protease, Serine 6 (TMPRSS6) Antisense Oligonucleotide (IONIS-TMPRSS6-LRX) Reduces Plasma Iron Levels of Healthy Volunteers in a Phase 1 Clinical Study

Shuling Guo, B. Monia, R. Geary, 2018, Blood.

Developing a Galnac-Conjugated TMPRSS6 Antisense Therapy for the Treatment of β-Thalassemia

S. Rivella, Shuling Guo, B. Monia, 2016 .

Antisense oligonucleotide‐mediated knockdown of Mpzl3 attenuates the negative metabolic effects of diet‐induced obesity in mice

B. Monia, N. Hempel, Amy C. Arnold, 2021, Physiological reports.

ISIS-FXIRx, A Novel and Specific Antisense Inhibitor of Factor XI, Caused Significant Reduction in FXI Antigen and Activity and Increased aPTT without Causing Bleeding in Healthy Volunteers

B. Monia, S. Bhanot, C. Bethune, 2011 .

Ubiquitin fusion augments the yield of cloned gene products in Escherichia coli.

D. Ecker, T. Butt, B. Monia, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Antisense inhibition of proprotein convertase subtilisin/kexin type 9 reduces serum LDL in hyperlipidemic mice Published, JLR Papers in Press, January 22, 2007.

B. Monia, S. Crooke, M. Graham, 2007, Journal of Lipid Research.

Targeting the contact system in a rabbit model of extracorporeal membrane oxygenation

B. Monia, J. Tweddell, F. Zafar, 2022, Blood advances.

Inotersen (transthyretin-specific antisense oligonucleotide) for treatment of transthyretin amyloidosis.

M. Benson, B. Monia, N. Dasgupta, 2019, Neurodegenerative disease management.

Hereditary transthyretin amyloidosis: baseline characteristics of patients in the NEURO-TTR trial

M. Benson, P. Dyck, B. Monia, 2018, Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.

PKCepsilon plays a causal role in acute ethanol-induced steatosis.

G. Arteel, B. Monia, Jun Zhang, 2009, Archives of biochemistry and biophysics.

Evaluation of the Antihemostatic and Antithrombotic Effects of Lowering Coagulation Factor VII Levels in a Non-human Primate

O. McCarty, A. Gruber, M. Hinds, 2020, Cellular and molecular bioengineering.

Knockdown of the gene encoding Drosophila tribbles homologue 3 (Trib3) improves insulin sensitivity through peroxisome proliferator-activated receptor-γ (PPAR-γ) activation in a rat model of insulin resistance

G. Shulman, G. Cline, B. Monia, 2011, Diabetologia.

Factor XI Antisense Oligonucleotide for Prevention of Venous Thrombosis

G. Raskob, H. Büller, B. Monia, 2014 .

Increasing gene expression in yeast by fusion to ubiquitin.

J. A. Gorman, D. Ecker, T. Butt, 1989, The Journal of biological chemistry.

Factor XI Regulates Pathological Thrombus Formation on Acutely Ruptured Atherosclerotic Plaques

B. Monia, S. Bhanot, J. Heemskerk, 2014, Arteriosclerosis, thrombosis, and vascular biology.

Inhibition of Bcl-xL expression sensitizes T-cell acute lymphoblastic leukemia cells to chemotherapeutic drugs.

B. Monia, N. Dean, M. Diccianni, 2002, Leukemia research.

Antisense as a Novel Therapy for Cancer

B. Monia, 2000 .

INOTERSEN IMPROVES QUALITY OF LIFE IN PATIENTS WITH HEREDITARY TRANSTHYRETIN AMYLOIDOSIS WITH POLYNEUROPATHY AND CARDIOMYOPATHY: RESULTS OF THE PHASE 3 STUDY NEURO-TTR

M. Maurer, M. Benson, B. Monia, 2018 .

Phase 1 Investigation of a Ligand-Conjugated Antisense Oligonucleotide with Increased Potency for the Treatment of Transthyretin Amyloidosis

Shuling Guo, B. Monia, B. Baker, 2019, Journal of Cardiac Failure.

Antisense therapy for cancer

M. Gleave, B. Monia, Brett P. Monia, 2005, Nature Reviews Cancer.

Antitumor activity of a phosphorothioate antisense oligodeoxynucleotide targeted against C-raf kinase

Doriano Fabbro, D. Fabbro, B. Monia, 1996, Nature Medicine.

PKC-ε Is Required for Mechano-sensitive Activation of ERK1/2 in Endothelial Cells*

B. Monia, N. Dean, B. Berk, 1997, The Journal of Biological Chemistry.

INHIBITION OF C-RAF EXPRESSION BY ANTISENSE OLIGONUCLEOTIDES EXTENDS HEART ALLOGRAFT SURVIVAL IN RATS1

B. Monia, C. Bennett, S. Stepkowski, 2000, Transplantation.

Telomerase inhibition, telomere shortening, and decreased cell proliferation by cell permeable 2'-O-methoxyethyl oligonucleotides.

D. Corey, B. Monia, Zhi Chen, 2002, Journal of medicinal chemistry.

Inhibition of Bcl-xL expression sensitizes normal human keratinocytes and epithelial cells to apoptotic stimuli

B. Monia, Q. Zhang, N. Dean, 1999, Oncogene.

Effects of Antisense Oligonucleotide-Mediated Depletion of Tumor Necrosis Factor (TNF) Receptor 1-Associated Death Domain Protein on TNF-Induced Gene Expression

J. Pober, B. Monia, L. Madge, 2004 .

Antisense oligonucleotide reduction of DGAT2 expression improves hepatic steatosis and hyperlipidemia in obese mice.

B. Monia, Xing Yu, S. Pandey, 2005 .

Inhibition of protein tyrosine phosphatase-1B with antisense oligonucleotides improves insulin sensitivity and increases adiponectin concentrations in monkeys.

B. Monia, S. Booten, S. Murray, 2009, Endocrinology.

Reduction of JNK1 expression with antisense oligonucleotide improves adiposity in obese mice.

B. Monia, Xing Yu, S. Booten, 2008, American journal of physiology. Endocrinology and metabolism.

Targeting Hepcidin with Antisense Oligonucletides Improves Anemia Endpoints in Mice.

B. Monia, A. Watt, G. Hung, 2006 .

A human ubiquitin carboxyl extension protein functions in yeast.

D. Ecker, D. Finley, B. Monia, 1990, The Journal of biological chemistry.