P. Chiao

发表

The Molecular Biology of Pancreatic Cancer

Douglas B. Evans, M. E. Jean, A. Lowy, 2002 .

PA-1, a human cell model for multistage carcinogenesis: oncogenes and other factors.

D. Krizman, M. Tainsky, B. Giovanella, 1988, Anticancer research.

Immune Cell Production of Interleukin 17 Induces Stem Cell Features of Pancreatic Intraepithelial Neoplasia Cells.

A. Maitra, S. Leach, Kyle Chang, 2018, Gastroenterology.

Activation of human Kupffer cells by thymostimulin (TP-1) to produce cytotoxicity against human hepatocellular cancer

F. Izzo, S. Curley, P. Chiao, 2006, Annals of Surgical Oncology.

Autoregulation of I kappa B alpha activity.

I. Verma, P. Chiao, S. Miyamoto, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Reduction of TRAIL-induced Mcl-1 and cIAP2 by c-Myc or sorafenib sensitizes resistant human cancer cells to TRAIL-induced death.

K. Flaherty, W. El-Deiry, D. Dicker, 2007, Cancer cell.

Targeted expression of BikDD eradicates pancreatic tumors in noninvasive imaging models.

Douglas B. Evans, M. Hung, W. Xia, 2007, Cancer cell.

Expression of Concern: Cooperativity of Oncogenic K-Ras and Downregulated p16/INK4A in Human Pancreatic Tumorigenesis

J. Cheng, Dihua Yu, Huamin Wang, 2019, PloS one.

Deciphering the Mechanisms of Tumorigenesis in Human Pancreatic Ductal Epithelial Cells

Huamin Wang, D. Chatterjee, J. Fleming, 2013, Clinical Cancer Research.

Overexpression of urokinase-type plasminogen activator in pancreatic adenocarcinoma is regulated by constitutively activated RelA

Douglas B. Evans, J. Abbruzzese, P. Chiao, 1999, Oncogene.

Inhibition of nuclear factor-κB augments antitumor activity of adenovirus-mediated melanoma differentiation-associated gene-7 against lung cancer cells via mitogen-activated protein kinase kinase kinase 1 activation

R. Ramesh, B. Gopalan, S. Chada, 2007, Molecular Cancer Therapeutics.

Overcoming acquired resistance to TRAIL by chemotherapeutic agents and calpain inhibitor I through distinct mechanisms.

P. Chiao, B. Fang, Lidong Zhang, 2004, Molecular therapy : the journal of the American Society of Gene Therapy.

Micro-RNA-155 is induced by K-Ras oncogenic signal and promotes ROS stress in pancreatic cancer

P. Chiao, Peng Huang, Z. Zeng, 2015, Oncotarget.

Prognostic factors in resectable pancreatic cancer: p53 and Bcl-2

K. Hess, C. Bucana, Douglas B. Evans, 1999, Journal of Gastrointestinal Surgery.

Mechanisms of Overcoming Intrinsic Resistance to Gemcitabine in Pancreatic Ductal Adenocarcinoma through the Redox Modulation

T. Gocho, P. Chiao, Peng Huang, 2014, Molecular Cancer Therapeutics.

Tumor suppressor gene Smad4/DPC4, its downstream target genes, and regulation of cell cycle.

W. Zhang, K. Hunt, T. Breslin, 1999, Annals of the New York Academy of Sciences.

Function of nuclear factor kappaB in pancreatic cancer metastasis.

Douglas B. Evans, J. Abbruzzese, P. Chiao, 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

Retracted: In vitro and in vivo molecular evidence of genistein action in augmenting the efficacy of cisplatin in pancreatic cancer

Zhiwei Wang, Sanjeev Banerjee, F. Sarkar, 2007, International journal of cancer.

ERK kinase phosphorylates and destabilizes the tumor suppressor FBW7 in pancreatic cancer

P. Chiao, Daming Gao, Hu Zhou, 2015, Cell Research.

Role of Rel/NF‐κB transcription factors in apoptosis of human hepatocellular carcinoma cells

S. Curley, P. Chiao, G. Sclabas, 2002, Cancer.

Overexpression of tropomysin-related kinase B in metastatic human pancreatic cancer cells.

Wei Zhang, K. Hess, Douglas B. Evans, 2005, Clinical cancer research : an official journal of the American Association for Cancer Research.

Restoring apoptosis in pancreatic cancer cells by targeting the nuclear factor-κb signaling pathway with the anti-epidermal growth factor antibody IMC-C225

Douglas B. Evans, P. Chiao, Z. Fan, 2003, Journal of Gastrointestinal Surgery.

Circulating levels of hydroxylated bradykinin function as an indicator of tissue HIF-1α expression.

Christopher J. Lyon, M. Katz, P. Chiao, 2020, Science bulletin.

Suppression of the SLC7A11/glutathione axis causes synthetic lethality in KRAS-mutant lung adenocarcinoma.

F. Cheng, Mingyao Liu, Xiufeng Pang, 2019, The Journal of clinical investigation.

Suppression of tumorigenesis and induction of p15(ink4b) by Smad4/DPC4 in human pancreatic cancer cells.

Douglas B. Evans, D. Ayers, T. Breslin, 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.

Nanotrap-enabled quantification of KRAS-induced peptide hydroxylation in blood for cancer early detection

Xifeng Wu, Y. Ye, P. Chiao, 2019, Nano Research.

drp, a novel protein expressed at high cell density but not during growth arrest.

M. Tainsky, P. Chiao, J. Deyo, 1998, DNA and cell biology.

The proto-oncogene bcl-3 encodes an I kappa B protein.

G. Nabel, I. Verma, C. Duckett, 1992, Genes & development.

Identification of cisplatin sensitizers through high-throughput combinatorial screening.

P. Chiao, Peng Huang, J. Ling, 2018, International journal of oncology.

Bortezomib inhibits PKR-like endoplasmic reticulum (ER) kinase and induces apoptosis via ER stress in human pancreatic cancer cells.

D. McConkey, J. Abbruzzese, P. Chiao, 2005, Cancer research.

Pancreatic Cancer Cells Kinase and Induces Apoptosis via ER Stress in Human Bortezomib Inhibits PKR-Like Endoplasmic Reticulum ( ER )

D. McConkey, J. Abbruzzese, P. Chiao, 2005 .

Inhibition of constitutively activated nuclear factor-kappaB radiosensitizes human melanoma cells.

M. Andreeff, R. Meyn, P. Chiao, 2004, Molecular cancer therapeutics.

Inhibition of constitutively activated nuclear factor-κB radiosensitizers human cells

M. Andreeff, R. Meyn, P. Chiao, 2004 .

Overexpression of synuclein‐γ in pancreatic adenocarcinoma

K. Hess, Douglas B. Evans, J. Abbruzzese, 2004 .

Role for the double-stranded RNA activated protein kinase PKR in E2F-1-induced apoptosis

L. Ellis, K. Hunt, S. Swisher, 2002, Oncogene.

Mitogen-activated Protein Kinase Kinase-4 Promotes Cell Survival by Decreasing PTEN Expression through

W. Yung, P. Brown, I. Wistuba, 2007 .

Mitogen-activated Protein Kinase Kinase-4 Promotes Cell Survival by Decreasing PTEN Expression through an NFκB-dependent Pathway*

W. Yung, P. Brown, I. Wistuba, 2006, Journal of Biological Chemistry.

Function of polo-like kinase 3 in NF-kappaB-mediated proapoptotic response.

P. Chiao, Zhongkui Li, Jiangong Niu, 2005, The Journal of biological chemistry.

Identification of an autoregulatory feedback pathway involving interleukin-1alpha in induction of constitutive NF-kappaB activation in pancreatic cancer cells.

P. Chiao, Zhongkui Li, Jiangong Niu, 2004, The Journal of biological chemistry.

Two Birds with One Stone: Therapeutic Targeting of IL1α Signaling Pathways in Pancreatic Ductal Adenocarcinoma and the Cancer-Associated Fibroblasts.

P. Chiao, J. Ling, 2019, Cancer discovery.

Molecular evidence for increased antitumor activity of gemcitabine by genistein in vitro and in vivo using an orthotopic model of pancreatic cancer.

Zhiwei Wang, Shadan Ali, Sanjeev Banerjee, 2005, Cancer research.

E1A sensitizes cells to tumor necrosis factor-induced apoptosis through inhibition of IkappaB kinases and nuclear factor kappaB activities.

M. C. Hu, M. Hung, B. Spohn, 1999, The Journal of biological chemistry.

Inhibition of the transcription factor nuclear factor-κB by adenoviral- mediated expression of IκBαM results in tumor cell death

K. Hunt, Dihua Yu, B. Feig, 1999 .

Enhanced IKBot Degradation Is Responsible for Constitutive NF-KB Activity in Mature Murine B-Cell Lines

I. Verma, P. Chiao, S. Miyamoto, 2022 .

The Nuclear Factor-kB RelA Transcription Factor Is Constitutively Activated in Human Pancreatic Adenocarcinoma Cells

Douglas B. Evans, J. Abbruzzese, K. Cleary, 1998 .

Inhibition of Nuclear Factor-κB Activity Is Involved in E1A-mediated Sensitization of Radiation-induced Apoptosis*

M. Hung, B. Zhou, P. Chiao, 1997, The Journal of Biological Chemistry.

Nardilysin-Regulated Scission Mechanism Activates Polo-like Kinase 3 to Suppress the Development of Pancreatic Cancer

Yu Cao, J. Tainer, A. Maitra, 2022, bioRxiv.

Activation of the Transcription Factor c-Maf in T Cells Is Dependent on the CARMA1-IKKβ Signaling Cascade

R. Nurieva, P. Chiao, Shao-Cong Sun, 2013, Science Signaling.

SOX9 activity is induced by oncogenic Kras to affect MDC1 and MCMs expression in pancreatic cancer

P. Chiao, L. Song, J. Ling, 2018, Oncogene.

NF-κB Activation Is Not Required for Chlamydia trachomatis Inhibition of Host Epithelial Cell Apoptosis1

G. Zhong, P. Chiao, Youmin Zhong, 2005, The Journal of Immunology.

NF- B Activation Is Not Required for Chlamydia trachomatis Inhibition of Host Epithelial Cell Apoptosis

G. Zhong, P. Chiao, Youmin Zhong, 2005 .

NF-kBActivation Upregulates PKM2 Expression and Promotes Tumorigenesis

K. Aldape, T. Kornberg, I. Verma, 2018 .

14-3-3ζ Cooperates with ErbB2 to Promote Progression of Ductal Carcinoma in Situ to Invasive Breast Cancer by Inducing Epithelial-Mesenchymal Transition

Ling, M. Hung, Dihua Yu, 2009 .

14-3-3 z Cooperates with ErbB2 to Promote Ductal Carcinoma In Situ Progression to Invasive Breast Cancer by Inducing Epithelial-Mesenchymal Transition

M. Hung, Dihua Yu, V. Seewaldt, 2009 .

Kras, Pten, NF-κB, and inflammation: dangerous liaisons.

P. Chiao, J. Ling, 2011, Cancer discovery.

NF-kappaB in pancreatic cancer.

Douglas B. Evans, P. Chiao, C. Schmidt, 2003, International journal of gastrointestinal cancer.

Mechanisms of proinflammatory cytokine-induced biphasic NF-kappaB activation.

Douglas B. Evans, J. Abbruzzese, P. Chiao, 2003, Molecules and Cells.

Function of Nuclear Factor (cid:1) B in Pancreatic Cancer Metastasis 1

Douglas B. Evans, J. Abbruzzese, P. Chiao, 2003 .

Supplemental Data Reduction of TRAIL-Induced Mcl-1 and cIAP 2 by c-Myc or Sorafenib Sensitizes Resistant Human Cancer Cells to TRAIL-Induced Death

K. Flaherty, D. Dicker, Wenge Wang, 2007 .

Bik/NBK accumulation correlates with apoptosis-induction by bortezomib (PS-341, Velcade) and other proteasome inhibitors

Wei Guo, P. Chiao, B. Fang, 2005, Oncogene.

Inhibition of constitutive NF-kappa B activity by I kappa B alpha M suppresses tumorigenesis.

Douglas B. Evans, J. Abbruzzese, P. Chiao, 2003, Oncogene.

ATF4/TXNIP/REDD1/mTOR signaling mediates the antitumor activities of liver X receptor in pancreatic cancers

P. Chiao, J. Ling, Aijun Zhang, 2022, Cancer innovation.

Suppression of Tumorigenesis and Induction of p 15 ink 4 b by Smad 4 / DPC 4 in Human Pancreatic Cancer Cells 1

Douglas B. Evans, D. Ayers, T. Breslin, 2002 .

3D imaging analysis on an organoid-based platform guides personalized treatment in pancreatic ductal adenocarcinoma

Jeffrey E. Lee, R. DePinho, A. Maitra, 2022, The Journal of clinical investigation.

Regulation of nuclear translocation of HDAC3 by IkappaBalpha is required for tumor necrosis factor inhibition of peroxisome proliferator-activated receptor gamma function.

P. Chiao, Jianping Ye, Zhanguo Gao, 2006, The Journal of biological chemistry.

Stabilization of p53 is a novel mechanism for proapoptotic function of NF-kappaB.

Douglas B. Evans, Wei Zhang, J. Abbruzzese, 2004, Journal of Biological Chemistry.

Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate.

Jinsong Liu, G. Achanta, H. Pelicano, 2006, Cancer cell.

Inhibition of constitutive NF-κB activity by IκBαM suppresses tumorigenesis

Douglas B. Evans, J. Abbruzzese, P. Chiao, 2003, Oncogene.

Overexpressed WAF1/Cip1 renders glioblastoma cells resistant to chemotherapy agents 1,3-bis(2-chloroethyl)-1-nitrosourea and cisplatin.

M. Andreeff, V. Levin, W. Zhang, 1998, Cancer research.

Study human pancreatic cancer in mice: how close are they?

J. Fleming, P. Chiao, C. Logsdon, 2013, Biochimica et biophysica acta.

Regulation of the Nampt-mediated NAD salvage pathway and its therapeutic implications in pancreatic cancer.

P. Chiao, R. Xu, Hai-jun Zhou, 2016, Cancer letters.

14-3-3zeta Cooperates with ErbB2 to promote ductal carcinoma in situ progression to invasive breast cancer by inducing epithelial-mesenchymal transition.

M. Hung, A. Sahin, Dihua Yu, 2009, Cancer cell.

14-3-3 z Cooperates with ErbB 2 to Promote Ductal Carcinoma In Situ Progression to Invasive Breast Cancer by Inducing Epithelial-Mesenchymal Transition

M. Hung, A. Sahin, Dihua Yu, 2009 .

MicroRNA Signaling Pathway Network in Pancreatic Ductal Adenocarcinoma.

Wei Zhang, P. Chiao, Longhao Sun, 2015, Journal of genetics and genomics = Yi chuan xue bao.

Amphiregulin in Cancer: New Insights for Translational Medicine.

P. Chiao, Yu Sun, Qixia Xu, 2016, Trends in cancer.

Long non-coding RNA UICLM promotes colorectal cancer liver metastasis by acting as a ceRNA for microRNA-215 to regulate ZEB 2 expression

Fenghua Wang, Yu-hong Li, Z. Pan, 2017 .

Modulation of Redox Homeostasis by Inhibition of MTHFD2 in Colorectal Cancer: Mechanisms and Therapeutic Implications

M. Hung, P. Chiao, Peng Huang, 2018, Journal of the National Cancer Institute.

Mutant Kras- and p16-regulated NOX4 activation overcomes metabolic checkpoints in development of pancreatic ductal adenocarcinoma

Jun Yao, R. DePinho, M. Hung, 2017, Nature Communications.

Tumor-associated nonmyelinating Schwann cell–expressed PVT1 promotes pancreatic cancer kynurenine pathway and tumor immune exclusion

Jun Yao, G. Calin, M. Hung, 2023, Science advances.

Long non-coding RNA UICLM promotes colorectal cancer liver metastasis by acting as a ceRNA for microRNA-215 to regulate ZEB2 expression

Fenghua Wang, Yu-hong Li, Z. Pan, 2017, Theranostics.

IGFBP2 Activates the NF-κB Pathway to Drive Epithelial-Mesenchymal Transition and Invasive Character in Pancreatic Ductal Adenocarcinoma.

Wei Zhang, Yuexin Liu, Limei Hu, 2016, Cancer research.

Updated Landscape of the Tumor Microenvironment and Targeting Strategies in an Era of Precision Medicine

P. Chiao, Yu Sun, 2017 .

Adenovirus-mediated wild-typep53 tumor suppressor gene therapy induces apoptosis and suppresses growth of human pancreatic cancer

Michael Bouvet, Richard J. Bold, David J. McConkey, 1998, Annals of Surgical Oncology.

Adenovirus-mediated wild-type p53 tumor suppressor gene therapy induces apoptosis and suppresses growth of human pancreatic cancer [seecomments].

J. Roth, R. Bold, D. McConkey, 1998, Annals of surgical oncology.

N-ras oncogene causes AP-2 transcriptional self-interference, which leads to transformation.

M. Sarkiss, M. Tainsky, P. Chiao, 1994, Genes & development.

NF-κB in pancreatic cancer

Douglas B. Evans, P. Chiao, C. Schmidt, 2003 .

SelectivekillingofoncogenicallytransformedcellsthroughaROS- mediated mechanism by b-phenylethyl isothiocyanate

Jinsong Liu, G. Achanta, H. Pelicano, 2006 .

Defective feedback regulation of NF-κB underlies Sjögren’s syndrome in mice with mutated κB enhancers of the IκBα promoter

Huamin Wang, J. Fleming, P. Chiao, 2010, Proceedings of the National Academy of Sciences.

Doxycycline induces apoptosis in PANC-1 pancreatic cancer cells.

P. Chiao, Hisashi Yamada, K. Yanaga, 2009, Anticancer research.

Function of Nuclear Factor κB in Pancreatic Cancer Metastasis

Douglas B. Evans, J. Abbruzzese, P. Chiao, 2003 .

Overexpressed WAFl / Cipl Renders Glioblastoma Cells Resistant to Chemotherapy Agents l , 3-Bis ( 2-chloroethyl )-l-nitrosourea and Cisplatin 1

Wei Zhang, V. Levin, Michael, 2006 .

The current state of oncogenes and cancer: Experimental approaches for analyzing oncogenetic events in human cancer

L. Strong, M. Tainsky, F. Bischoff, 1990, Cancer and Metastasis Reviews.

KrasG12D-induced IKK2/β/NF-κB activation by IL-1α and p62 feedforward loops is required for development of pancreatic ductal adenocarcinoma.

Ruiying Zhao, Dung-Fang Lee, Jinsong Liu, 2012, Cancer cell.

Cooperativity of Oncogenic K-Ras and Downregulated p16/INK4A in Human Pancreatic Tumorigenesis

Dihua Yu, Huamin Wang, J. Fleming, 2014, PloS one.

In vitro modeling of human pancreatic duct epithelial cell transformation defines gene expression changes induced by K-ras oncogenic activation in pancreatic carcinogenesis.

M. Tsao, P. Chiao, Ming Li, 2005, Cancer research.

The senescence-associated secretory phenotype is potentiated by feedforward regulatory mechanisms involving Zscan4 and TAK1

E. Lam, P. Chiao, Yushui Ma, 2018, Nature Communications.

Aggresome disruption: a novel strategy to enhance bortezomib-induced apoptosis in pancreatic cancer cells.

M. Pino, D. McConkey, J. Abbruzzese, 2006, Cancer research.

Melatonin overcomes gemcitabine resistance in pancreatic ductal adenocarcinoma by abrogating nuclear factor‐κB activation

Long Bai, P. Chiao, R. Xu, 2016, Journal of pineal research.

The proto-oncogene BCL-3 encodes an IκB protein

G. Nabel, I. Verma, C. Duckett, 1992 .

Modulation of pancreatic cancer chemoresistance by inhibition of TAK1.

D. Melisi, J. Abbruzzese, P. Chiao, 2011, Journal of the National Cancer Institute.

Keratinocyte Growth Factor/Fibroblast Growth Factor-7-regulated Cell Migration and Invasion through Activation of NF-κB Transcription Factors*

Peng Huang, Ming-Sound Tsao, M. Tsao, 2007, Journal of Biological Chemistry.

Coactivators and Corepressors of NF-κB in IκBα Gene Promoter*

M. Lazar, E. Seto, H. Young, 2005, Journal of Biological Chemistry.

FBW7 (F-box and WD Repeat Domain-Containing 7) Negatively Regulates Glucose Metabolism by Targeting the c-Myc/TXNIP (Thioredoxin-Binding Protein) Axis in Pancreatic Cancer

P. Chiao, Xianjun Yu, Liang Liu, 2016, Clinical Cancer Research.

The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells.

J. Abbruzzese, K. Cleary, P. Chiao, 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.

The Nuclear Factor-κB RelA Transcription Factor Is Constitutively Activated in Human Pancreatic Adenocarcinoma Cells

Douglas B. Evans, J. Abbruzzese, K. Cleary, 1999 .

Suppression of stromal-derived Dickkopf-3 (DKK3) inhibits tumor progression and prolongs survival in pancreatic ductal adenocarcinoma

Jeffrey E. Lee, C. Niehrs, A. Maitra, 2018, Science Translational Medicine.

NF-κB and AP-1 Connection: Mechanism of NF-κB-Dependent Regulation of AP-1 Activity

Christian Schmidt, James L. Abbruzzese, Douglas B. Evans, 2004, Molecular and Cellular Biology.

Cell cycle regulation of human pancreatic cancer by tamoxifen

Douglas B. Evans, J. Abbruzzese, P. Chiao, 1998, Annals of Surgical Oncology.

An angiopoietin-like protein 2 autocrine signaling promotes EMT during pancreatic ductal carcinogenesis

M. Fassan, A. Scarpa, C. Bassi, 2014, Oncotarget.

SMAD4 Regulates Cell Motility through Transcription of N-Cadherin in Human Pancreatic Ductal Epithelium

Huamin Wang, D. Chatterjee, M. Katz, 2014, PloS one.

Transforming Growth Factor-β Limits Secretion of Lumican by Activated Stellate Cells within Primary Pancreatic Adenocarcinoma Tumors

Huamin Wang, D. Chatterjee, M. Katz, 2016, Clinical Cancer Research.

Combination chemotherapy of nafamostat mesilate with gemcitabine for pancreatic cancer targeting NF-kappaB activation.

T. Misawa, T. Gocho, P. Chiao, 2009, Anticancer research.

Circular RNAs regulate cancer-related signaling pathways and serve as potential diagnostic biomarkers for human cancers

P. Chiao, Jie Fu, Jinjie Ling, 2021, Cancer cell international.

Potential role of Jun activation domain-binding protein 1 as a negative regulator of p27kip1 in pancreatic adenocarcinoma.

Douglas B. Evans, G. Rassidakis, P. Chiao, 2006, Cancer research.

The Biphasic Role of NF-κB in Progression and Chemoresistance of Ovarian Cancer

Gong Yang, D. Rosen, I. Mercado-uribe, 2011, Clinical Cancer Research.

TAK-ing aim at chemoresistance: The emerging role of MAP3K7 as a target for cancer therapy.

D. Melisi, P. Chiao, R. Santoro, 2017, Drug resistance updates.

NF-kappaB and AP-1 connection: mechanism of NF-kappaB-dependent regulation of AP-1 activity.

Douglas B. Evans, J. Abbruzzese, P. Chiao, 2004, Molecular and cellular biology.

Current Approaches and Future Strategies for Pancreatic Carcinoma

Jeffrey E. Lee, Douglas B. Evans, R. Wolff, 2000, Investigational New Drugs.

Identification of an Autoregulatory Feedback Pathway Involving Interleukin-1α in Induction of Constitutive NF-κB Activation in Pancreatic Cancer Cells*

P. Chiao, Zhongkui Li, Jiangong Niu, 2004, Journal of Biological Chemistry.

LY2109761, a novel transforming growth factor β receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis

G. Tortora, D. Melisi, J. Fleming, 2008, Molecular Cancer Therapeutics.

Regulation of PD-L1 expression in K-ras-driven cancers through ROS-mediated FGFR1 signaling

C. Glorieux, P. Chiao, Peng Huang, 2020, Redox biology.

The senescence-associated secretory phenotype is potentiated by feedforward regulatory mechanisms involving Zscan4 and TAK1

E. Lam, P. Chiao, Yushui Ma, 2018, Nature Communications.

Oral Poly(ADP-Ribose) Polymerase-1 Inhibitor BSI-401 Has Antitumor Activity and Synergizes with Oxaliplatin against Pancreatic Cancer, Preventing Acute Neurotoxicity

P. Dougherty, D. Melisi, J. Abbruzzese, 2009, Clinical Cancer Research.

Anti-VEGF Treatment–Resistant Pancreatic Cancers Secrete Proinflammatory Factors That Contribute to Malignant Progression by Inducing an EMT Cell Phenotype

D. Melisi, J. Abbruzzese, P. Chiao, 2011, Clinical Cancer Research.

CES2 sustains HNF4α expression to promote pancreatic adenocarcinoma progression through an epoxide hydrolase-dependent regulatory loop

Jennifer B Dennison, S. Hanash, O. Fiehn, 2021, Molecular metabolism.

Desensitization of NFκB for overcoming chemoresistance of pancreatic cancer cells to TNF-α or paclitaxel.

P. Chiao, K. Yanaga, T. Fujita, 2012, Anticancer research.

Function of Polo-like Kinase 3 in NF-κB-mediated Proapoptotic Response*

P. Chiao, Zhongkui Li, Jiangong Niu, 2005, Journal of Biological Chemistry.

Stabilization of p53 Is a Novel Mechanism for Proapoptotic Function of NF-κB*

Peng Huang, Christian Schmidt, James L. Abbruzzese, 2004, Journal of Biological Chemistry.

E1A Sensitizes Cells to Tumor Necrosis Factor-induced Apoptosis through Inhibition of IκB Kinases and Nuclear Factor κB Activities*

M. Hung, Shiaw-Yih Lin, B. Zhou, 1999, The Journal of Biological Chemistry.

Mechanisms of Proinflammatory Cytokine-Induced Biphasic NF-κB Activation.

Douglas B. Evans, J. Abbruzzese, P. Chiao, 2003 .

The function of multiple IkappaB : NF-kappaB complexes in the resistance of cancer cells to Taxol-induced apoptosis.

Douglas B. Evans, T. McDonnell, M. Tsao, 2002, Oncogene.

Enhanced I kappa B alpha degradation is responsible for constitutive NF-kappa B activity in mature murine B-cell lines

I. Verma, P. Chiao, S. Miyamoto, 1994, Molecular and cellular biology.

IL1 Receptor Antagonist Inhibits Pancreatic Cancer Growth by Abrogating NF-κB Activation

D. Melisi, J. Fleming, P. Chiao, 2015, Clinical Cancer Research.

IL 1 Receptor Antagonist Inhibits Pancreatic Cancer Growth by Abrogating NFk B Activation

D. Melisi, J. Fleming, P. Chiao, 2016 .

IL1 Receptor Antagonist Inhibits Pancreatic Cancer Growth by Abrogating NF-κB Activation

D. Melisi, J. Fleming, P. Chiao, 2015, Clinical Cancer Research.

Cisplatin and gemcitabine exert opposite effects on immunotherapy with PD-1 antibody in K-ras-driven cancer

Huamin Wang, P. Chiao, Hui Zhang, 2021, Journal of advanced research.

CES2 Expression in Pancreatic Adenocarcinoma Is Predictive of Response to Irinotecan and Is Associated With Type 2 Diabetes.

Jennifer B Dennison, S. Hanash, O. Fiehn, 2020, JCO precision oncology.

Molecular genetics of pancreatic cancer

K. Hess, F. Sinicrope, R. Bold, 1998 .

Induction of p21waf1 expression and growth inhibition by transforming growth factor beta involve the tumor suppressor gene DPC4 in human pancreatic adenocarcinoma cells.

Wei Zhang, W. Zhang, J. Abbruzzese, 1997, Cancer research.

NF-κB as a target for cancer therapy

D. Melisi, P. Chiao, 2007 .

Nuclear factor kappa B activation is a potential target for preventing pancreatic carcinoma by aspirin

K. Hess, Douglas B. Evans, J. Abbruzzese, 2005, Cancer.

Induction of apoptosis in tumor-associated endothelial cells and therapy of orthotopic human pancreatic carcinoma in nude mice.

D. Nam, I. Fidler, J. Abbruzzese, 2005, Neoplasia.

TrkBT1 induces liver metastasis of pancreatic cancer cells by sequestering Rho GDP dissociation inhibitor and promoting RhoA activation.

Douglas B. Evans, J. Fleming, P. Chiao, 2009, Cancer research.

Secreted Interleukin-1α Induces a Metastatic Phenotype in Pancreatic Cancer by Sustaining a Constitutive Activation of Nuclear Factor-κB

Douglas B. Evans, D. Melisi, P. Chiao, 2009, Molecular Cancer Research.

K-rasG12V transformation leads to mitochondrial dysfunction and a metabolic switch from oxidative phosphorylation to glycolysis

G. Garcia-Manero, H. Pelicano, P. Chiao, 2011, Cell Research.

Inhibition of nuclear factor-kappaB activity is involved in E1A-mediated sensitization of radiation-induced apoptosis.

M. Hung, P. Chiao, R. Shao, 1997, The Journal of biological chemistry.

DNA adducts in human pancreatic tissues and their potential role in carcinogenesis.

H. Friess, Donghui Li, W. Hittelman, 1998, Cancer research.

A novel epigenetic CREB-miR-373 axis mediates ZIP4-induced pancreatic cancer growth

Huamin Wang, W. Fisher, P. Chiao, 2013, EMBO molecular medicine.

Overexpression of the tumor suppressor gene Smad4/DPC4 induces p21waf1 expression and growth inhibition in human carcinoma cells.

K. Hunt, J. Fleming, P. Chiao, 1998, Cancer research.

Modulation of differentiation in PA-1 human teratocarcinoma cells after N-ras oncogene-induced tumorigenicity.

D. Krizman, M. Tainsky, T. Mukhopadhyay, 1991, Oncogene.

EGFR-induced and PKCε monoubiquitylation-dependent NF-κB activation upregulates PKM2 expression and promotes tumorigenesis.

K. Aldape, Yu Cao, I. Verma, 2012, Molecular cell.

Regulation of Nuclear Translocation of HDAC3 by IκBα Is Required for Tumor Necrosis Factor Inhibition of Peroxisome Proliferator-activated Receptor γ Function*

P. Chiao, Jianping Ye, Zhanguo Gao, 2006, Journal of Biological Chemistry.

Src activation of Stat3 is an independent requirement from NF-κB activation for constitutive IL-8 expression in human pancreatic adenocarcinoma cells

D. McConkey, P. Chiao, J. Trevino, 2006, Angiogenesis.

The function of multiple IκB : NF-κB complexes in the resistance of cancer cells to Taxol-induced apoptosis

Douglas B. Evans, T. McDonnell, M. Tsao, 2002, Oncogene.

Overexpression of synuclein-gamma in pancreatic adenocarcinoma.

K. Hess, Douglas B. Evans, J. Abbruzzese, 2004, Cancer.

The overexpression of long intergenic ncRNA00162 induced by RelA/p65 promotes growth of pancreatic ductal adenocarcinoma

Jie Fu, P. Chiao, J. Ling, 2020, Cell proliferation.

EGFR-Induced and PKCε Monoubiquitylation-Dependent NF-κB Activation Upregulates PKM2 Expression and Promotes Tumorigenesis.

K. Aldape, I. Verma, P. Chiao, 2018, Molecular cell.

Oncogenic K-Ras and Loss of Smad4 Mediate Invasion by Activating an EGFR/NF-κB Axis That Induces Expression of MMP9 and uPA in Human Pancreas Progenitor Cells

J. Freeman, P. Chiao, A. Bera, 2013, PloS one.

Recombinant Thrombomodulin Has Anti-tumor Effects and Enhances the Effects of Gemcitabine for Pancreatic Cancer Through G-protein Coupled Receptor 15

Jie Fu, P. Chiao, J. Ling, 2022, AntiCancer Research.

NEMO peptide inhibits the growth of pancreatic ductal adenocarcinoma by blocking NF-κB activation.

P. Chiao, J. Ling, Min Wu, 2017, Cancer letters.

Inactivation of IκB contributes to transcriptional activation of spermidine/spermine N(1)‐acetyltransferase

Wei Zhang, E. Gerner, P. Chiao, 2006, Molecular carcinogenesis.

Keratinocyte growth factor/fibroblast growth factor-7-regulated cell migration and invasion through activation of NF-kappaB transcription factors.

Peng Huang, Ming-Sound Tsao, M. Tsao, 2007, The Journal of biological chemistry.

Development and Characterization of a ssDNA-based Aptamer that Selectively Targets Epithelial Carcinoma Cells

N. Zhao, Y. Zu, P. Chiao, 2014 .

Disruption of the NF-κB/IκBα Autoinhibitory Loop Improves Cognitive Performance and Promotes Hyperexcitability of Hippocampal Neurons

J. Noebels, P. Chiao, Hui Zheng, 2011, Molecular Neurodegeneration.

Mechanisms of synthetic serine protease inhibitor (FUT‐175)‐mediated cell death

Douglas B. Evans, M. Hung, J. Abbruzzese, 2007, Cancer.

Elevated expression of the ribosomal protein S2 gene in human tumors

M. Tainsky, P. Chiao, D. Shin, 1992, Molecular carcinogenesis.

Use of tetracycline operator system to regulate oncogene expression in mammalian cells.

P. Chiao, E. R. Eldredge, K. Lu, 1995, Methods in enzymology.

Tumor Suppressor Gene Smad4/DPC4, Its Downstream Target Genes, and Regulation of Cell Cyclea

K. Hunt, Douglas B. Evans, Wei Zhang, 1999 .

Advances in the diagnosis and treatment of adenocarcinoma of the pancreas.

Jeffrey E. Lee, L. Ellis, C. Charnsangavej, 1997, Cancer treatment and research.

NF-kappa B as a target for cancer therapy.

D. Melisi, P. Chiao, 2007, Expert opinion on therapeutic targets.

Study human pancreatic cancer in mice: how close are they?

J. Fleming, P. Chiao, C. Logsdon, 2013, Biochimica et biophysica acta.

KrasG12D-induced IKK2/β/NF-κB activation by IL-1α and p62 feedforward loops is required for development of pancreatic ductal adenocarcinoma.

M. Hung, Huamin Wang, I. Lemischka, 2012, Cancer cell.

TAK-ing aim at chemoresistance: The emerging role of MAP3K7 as a target for cancer therapy.

D. Melisi, P. Chiao, R. Santoro, 2017, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.

IGFBP2 Activates the NF-κB Pathway to Drive Epithelial-Mesenchymal Transition and Invasive Character in Pancreatic Ductal Adenocarcinoma.

Wei Zhang, Yuexin Liu, Limei Hu, 2016, Cancer research.

Oral Poly(ADP-Ribose) Polymerase-1 Inhibitor BSI-401 Has Antitumor Activity and Synergizes with Oxaliplatin against Pancreatic Cancer, Preventing Acute Neurotoxicity

P. Dougherty, D. Melisi, J. Abbruzzese, 2009, Clinical Cancer Research.

Susceptibility to ras oncogene transformation is coregulated with signal transduction through growth factor receptors.

D. Krizman, M. Tainsky, P. Chiao, 1991, Oncogene.

Malignant transformation by oncogenic K‐ras requires IDH2‐mediated reductive carboxylation to promote glutamine utilization

P. Chiao, Peng Huang, J. Ling, 2022, Cancer communications.

Mitogen-activated protein kinase kinase-4 promotes cell survival by decreasing PTEN expression through an NF kappa B-dependent pathway.

J. Kurie, P. Chiao, Xiaoyang Sheng, 2007, The Journal of biological chemistry.