K. Bhakat

发表

Multifaceted resistance of gliomas to temozolomide.

S. Finkelstein, S. Schold, D. Bocangel, 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.

Multifaceted Resistance of Gliomas to Temozolomide 1

S. Finkelstein, S. Schold, D. Bocangel, 2002 .

Two essential but distinct functions of the mammalian abasic endonuclease.

David J. Chen, K. Bhakat, S. Mitra, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Intracellular trafficking and regulation of mammalian AP-endonuclease 1 (APE1), an essential DNA repair protein.

K. Bhakat, S. Mitra, I. Boldogh, 2007, DNA repair.

Interaction of the Human DNA Glycosylase NEIL1 with Proliferating Cell Nuclear Antigen

C. Theriot, K. Bhakat, S. Mitra, 2008, Journal of Biological Chemistry.

Mdr1 Resistance Gene Yb-1-mediated Activation of the Multidrug Ap-endonuclease (ape1/ref-1) in Regulatory Role of Human Supplemental Material

K. Kohno, K. Bhakat, S. Mitra, 2008 .

Transcriptional regulatory functions of mammalian AP-endonuclease (APE1/Ref-1), an essential multifunctional protein.

K. Bhakat, S. Mitra, A. Mantha, 2009, Antioxidants & redox signaling.

Pan-Cancer Analysis Reveals the Diverse Landscape of Novel Sense and Antisense Fusion Transcripts

Chittibabu Guda, Shantaram S. Joshi, Jasjit K. Banwait, 2020, Molecular therapy. Nucleic acids.

Age-dependent modulation of DNA repair enzymes by covalent modification and subcellular distribution

K. Bhakat, S. Mitra, I. Boldogh, 2004, Mechanisms of Ageing and Development.

Red panda: a novel method for detecting variants in single-cell RNA sequencing

N. Mishra, C. Guda, K. Bhakat, 2020, BMC genomics.

Red panda: a novel method for detecting variants in single-cell RNA sequencing

N. Mishra, C. Guda, K. Bhakat, 2020, BMC Genomics.

Genetic susceptibility to thymic lymphomas and K‐ras gene mutation in mice after exposure to X‐rays and N‐ethyl‐N‐nitrosourea

K. Bhakat, Y. Shimada, J. Nagai, 2002, International journal of radiation biology.

The extracellular role of DNA damage repair protein APE1 in regulation of IL-6 expression.

S. Joshi, H. Band, K. Bhakat, 2017, Cellular signalling.

The mutK Gene of Vibrio cholerae: a New Gene Involved in DNA Mismatch Repair

K. Bhakat, J. Das, Sudarshana Sharma M., 1999, Journal of bacteriology.

Blockade of MGMT Expression by O6 Benzyl Guanine Leads to Inhibition of Pancreatic Cancer Growth and Induction of Apoptosis

K. Bhakat, J. Colon, S. Konduri, 2009, Clinical Cancer Research.

Nucleolar accumulation of APE1 depends on charged lysine residues that undergo acetylation upon genotoxic stress and modulate its BER activity in cells

A. Scaloni, C. Vascotto, G. Tell, 2012, Molecular biology of the cell.

The human AP-endonuclease 1 (APE1) is a DNA G-quadruplex structure binding protein and regulates KRAS expression in pancreatic ductal adenocarcinoma cells

P. Singh, K. Bhakat, L. Marky, 2022, Nucleic acids research.

Targeting Histone Chaperone FACT Complex Overcomes 5-Fluorouracil Resistance in Colon Cancer

V. Band, K. Bhakat, Jing Wang, 2019, Molecular Cancer Therapeutics.

Preferential Repair of Oxidized Base Damage in the Transcribed Genes of Mammalian Cells*

K. Bhakat, S. Mitra, I. Boldogh, 2010, The Journal of Biological Chemistry.

Dual Regulatory Roles of Human AP-Endonuclease (APE1/Ref-1) in CDKN1A/p21 Expression

Shiladitya Sengupta, K. Bhakat, S. Mitra, 2013, PloS one.

Cancer Therapy: Preclinical Blockade of MGMT Expression by O Benzyl Guanine Leads to Inhibition of Pancreatic Cancer Growth and Induction of Apoptosis

K. Bhakat, J. Colon, S. Konduri, 2009 .

Cancer Therapy : Preclinical Blockade of MGMT Expression by O 6 Benzyl Guanine Leads to Inhibition of Pancreatic Cancer Growth and Induction of Apoptosis

K. Bhakat, J. Colon, S. Konduri, 2009 .

Endogenous oxidized DNA bases and APE1 regulate the formation of G-quadruplex structures in the genome

V. Band, K. Bhakat, P. Sorgen, 2020, Proceedings of the National Academy of Sciences.

Regulation of mouse-renin gene by apurinic/apyrimidinic-endonuclease 1 (APE1/Ref-1) via recruitment of histone deacetylase 1 corepressor complex

Shiladitya Sengupta, K. Bhakat, S. Mitra, 2012, Journal of hypertension.

Induction of the Human Oxidized Base-specific DNA Glycosylase NEIL1 by Reactive Oxygen Species*

K. Bhakat, S. Mitra, I. Boldogh, 2005, Journal of Biological Chemistry.

Acetylation of human AP-endonuclease 1, a critical enzyme in DNA repair and transcription regulation.

K. Bhakat, S. Mitra, Sukmin Yang, 2003, Methods in enzymology.

Krüppel-like Factor 4 Is Acetylated by p300 and Regulates Gene Transcription via Modulation of Histone Acetylation*

X. Chen, K. Bhakat, Wen Zhang, 2007, Journal of Biological Chemistry.

Acetylation of oxidized base repair-initiating NEIL1 DNA glycosylase required for chromatin-bound repair complex formation in the human genome increases cellular resistance to oxidative stress.

Shiladitya Sengupta, K. Bhakat, S. Mitra, 2018, DNA repair.

Choreography of oxidative damage repair in mammalian genomes.

K. Bhakat, S. Mitra, I. Boldogh, 2002, Free radical biology & medicine.

Fine-tuning of DNA base excision/strand break repair via acetylation.

Shiladitya Sengupta, K. Bhakat, S. Mitra, 2020, DNA repair.

p53-Mediated down-regulation of the human DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) via interaction with Sp1 transcription factor.

Shiladitya Sengupta, D. Bocangel, K. Bhakat, 2009, Anticancer research.

p 53-Mediated Down-regulation of the Human DNA Repair Gene O 6-Methylguanine-DNA Methyltransferase ( MGMT ) via Interaction with Sp 1 Transcription Factor

Shiladitya Sengupta, D. Bocangel, K. Bhakat, 2009 .

CpG methylation-dependent repression of the human O6-methylguanine-DNA methyltransferase gene linked to chromatin structure alteration.

K. Bhakat, S. Mitra, 2003, Carcinogenesis.

Regulation of the HumanO 6-Methylguanine-DNA Methyltransferase Gene by Transcriptional Coactivators cAMP Response Element-binding Protein-binding Protein and p300*

K. Bhakat, S. Mitra, 2000, The Journal of Biological Chemistry.

Regulation of DNA Repair and Apoptosis by p53 and Its Impact on Alkylating Drug Resistance of Tumor Cells

D. Bocangel, K. Bhakat, S. Mitra, 2004 .

Subgroup-Specific Diagnostic, Prognostic, and Predictive Markers Influencing Pediatric Medulloblastoma Treatment

A. Rizzino, K. Bhakat, Nagendra K. Chaturvedi, 2021, Diagnostics.

Role of acetylated human AP‐endonuclease (APE1/Ref‐1) in regulation of the parathyroid hormone gene

K. Bhakat, S. Mitra, T. Hazra, 2003, The EMBO journal.

Oxidative genome damage and its repair: Implications in aging and neurodegenerative diseases

K. Bhakat, S. Mitra, T. Hazra, 2012, Mechanisms of Ageing and Development.

Mammalian DNA base excision repair proteins: their interactions and role in repair of oxidative DNA damage.

A. Jaiswal, K. Bhakat, S. Mitra, 2003, Toxicology.

The FAcilitates Chromatin Transcription (FACT) complex: Its roles in DNA repair and implications for cancer therapy.

K. Bhakat, Sutapa Ray, 2021, DNA repair.

Histone chaperone FACT complex inhibitor CBL0137 interferes with DNA damage repair and enhances sensitivity of medulloblastoma to chemotherapy and radiation.

K. Bhakat, D. Coulter, Jiping Zeng, 2021, Cancer letters.

Suppression of STAT3 NH2‐terminal domain chemosensitizes medulloblastoma cells by activation of protein inhibitor of activated STAT3 via de‐repression by microRNA‐21

S. Joshi, K. Bhakat, D. Coulter, 2018, Molecular carcinogenesis.

Human AP-endonuclease (APE1/Ref-1) and its acetylation regulate YB-1/p300 recruitment and RNA polymerase II loading in the drug induced activation of multidrug resistance gene MDR1

Shiladitya Sengupta, K. Bhakat, S. Mitra, 2010, Oncogene.

Acetylation of apurinic/apyrimidinic endonuclease-1 regulates Helicobacter pylori-mediated gastric epithelial cell apoptosis.

K. Bhakat, S. Mitra, Asima Bhattacharyya, 2009, Gastroenterology.

Methyl directed DNA mismatch repair inVibrio cholerae

C. Dutta, J. Das, K. Bhakat, 1994, J Biosci.

Regulation of the human AP-endonuclease (APE1/Ref-1) expression by the tumor suppressor p53 in response to DNA damage

K. Bhakat, S. Mitra, C. Busso, 2008, Nucleic acids research.

Human Apurinic/Apyrimidinic Endonuclease (APE1) Is Acetylated at DNA Damage Sites in Chromatin, and Acetylation Modulates Its DNA Repair Activity

Shiladitya Sengupta, K. Bhakat, A. Natarajan, 2016, Molecular and Cellular Biology.

Elevated level of acetylation of APE1 in tumor cells modulates DNA damage repair

Shiladitya Sengupta, K. Bhakat, A. Mantha, 2016, Oncotarget.

Regulation of limited N-terminal proteolysis of APE1 in tumor via acetylation and its role in cell proliferation

Shiladitya Sengupta, M. Sinha, B. Luxon, 2016, Oncotarget.

APE1 and SSRP1 is overexpressed in muscle invasive bladder cancer and associated with poor survival

Chad A. LaGrange, K. Bhakat, S. Lele, 2021, Heliyon.

O6-Methylguanine-DNA-methyltransferase promoter demethylation is involved in basic fibroblast growth factor–induced resistance against temozolomide in human melanoma cells

G. Peters, K. Bhakat, H. Pinedo, 2007, Molecular Cancer Therapeutics.

O 6-Methylguanine-DNA-methyltransferase promoter demethylation is involved in basic fibroblast growth factor – induced resistance against temozolomide in human melanoma cells

G. Peters, K. Bhakat, H. Pinedo, 2007 .

Acetylation of Human 8-Oxoguanine-DNA Glycosylase by p300 and Its Role in 8-Oxoguanine Repair In Vivo

K. Bhakat, S. Mitra, I. Boldogh, 2006, Molecular and Cellular Biology.

Reduced DNA double strand breaks in chlorambucil resistant cells are related to high DNA-PKcs activity and low oxidative stress.

K. Bhakat, S. Mitra, I. Boldogh, 2003, Toxicology.

Acetylation of the human DNA glycosylase NEIL2 and inhibition of its activity.

K. Bhakat, S. Mitra, T. Hazra, 2004, Nucleic acids research.

Regulation of signal transducer and activator of transcription 3 enhanceosome formation by apurinic/apyrimidinic endonuclease 1 in hepatic acute phase response.

K. Bhakat, A. Brasier, Chang Y. Lee, 2010, Molecular endocrinology.

Stimulation of NEIL2-mediated Oxidized Base Excision Repair via YB-1 Interaction during Oxidative Stress*

Samuel H. Wilson, K. Kohno, K. Bhakat, 2007, Journal of Biological Chemistry.

Unusual role of a cysteine residue in substrate binding and activity of human AP-endonuclease 1.

W. Braun, N. Oezguen, K. Bhakat, 2008, Journal of molecular biology.

STAT3 Inhibition Attenuates MYC Expression by Modulating Co-Activator Recruitment and Suppresses Medulloblastoma Tumor Growth by Augmenting Cisplatin Efficacy In Vivo

A. Rizzino, K. Bhakat, D. Coulter, 2023, Cancers.

APE1/Ref-1 regulates PTEN expression mediated by Egr-1

S. Gustincich, C. Vascotto, G. Tell, 2008, Free radical research.

Oxidized DNA Base Damage Repair and Transcription

K. Bhakat, Shrabasti Roychoudhury, Suravi Pramanik, 2021, Handbook of Oxidative Stress in Cancer: Mechanistic Aspects.

Regulatory Role of Human AP-Endonuclease (APE1/Ref-1) in YB-1-Mediated Activation of the Multidrug Resistance Gene MDR1

K. Kohno, K. Bhakat, S. Mitra, 2008, Molecular and Cellular Biology.

Biochemical and Cellular Assays to Assess the Effects of Acetylation on Base Excision Repair Enzymes.

K. Bhakat, Shrabasti Roychoudhury, Suravi Pramanik, 2019, Methods in molecular biology.

O6-Methylguanine-DNA-methyltransferase promoter demethylation is involved in basic fibroblast growth factor–induced resistance against temozolomide in human melanoma cells

G. Peters, K. Bhakat, H. Pinedo, 2007, Molecular Cancer Therapeutics.

Acetylation of oxidized base repair-initiating NEIL1 DNA glycosylase required for chromatin-bound repair complex formation in the human genome increases cellular resistance to oxidative stress.

Shiladitya Sengupta, K. Bhakat, S. Mitra, 2018, DNA repair.