H. Shu

发表

FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis.

D. Goeddel, S. Lowe, T. Mak, 1998, Science.

Crystal Structure of sTALL-1 Reveals a Virus-like Assembly of TNF Family Ligands

H. Shu, Yingfang Liu, Liangguo Xu, 2002, Cell.

TNF ligands (communication arising: response): Is Tall-1 a trimer or a virus-like cluster?

H. Shu, Yingfang Liu, Liangguo Xu, 2004, Nature.

Ligand–receptor binding revealed by the TNF family member TALL-1

Xia Hong, Hong-Bing Shu, Rongguang Zhang, 2003, Nature.

Identification of downstream genes up‐regulated by the tumor necrosis factor family member TALL‐1

Z. Zhai, H. Shu, Liang-Guo Xu, 2002, Journal of leukocyte biology.

B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1.

H. Shu, H. Johnson, H B Shu, 2000, Proceedings of the National Academy of Sciences of the United States of America.

FoxO1 Negatively Regulates Cellular Antiviral Response by Promoting Degradation of IRF3*

H. Shu, Bo Zhong, Cao-Qi Lei, 2013, The Journal of Biological Chemistry.

NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING.

Zhigang Zhang, H. Shu, Haitao Wen, 2014, Immunity.

Identification of Uteroglobin-Related Protein 1 and Macrophage Scavenger Receptor with Collagenous Structure as a Lung-Specific Ligand-Receptor Pair1

Larry D. Nielson, H. Shu, R. Mason, 2003, The Journal of Immunology.

TRADD–TRAF2 and TRADD–FADD Interactions Define Two Distinct TNF Receptor 1 Signal Transduction Pathways

Hong-Bing Shu, D. Goeddel, H. Shu, 1996, Cell.

Localization of A20 to a lysosome-associated compartment and its role in NFkappaB signaling.

J. Lippincott-Schwartz, D. Hailey, Y. Ye, 2008, Biochimica et biophysica acta.

ZNF216 Is an A20-like and IκB Kinase γ-Interacting Inhibitor of NFκB Activation*

Z. Zhai, H. Shu, Liang-Guo Xu, 2004, Journal of Biological Chemistry.

A20 is a potent inhibitor of TLR3‐ and Sendai virus‐induced activation of NF‐κB and ISRE and IFN‐β promoter

Hong-Bing Shu, Z. Zhai, H. Shu, 2004 .

CSN3 interacts with IKKγ and inhibits TNF‐ but not IL‐1‐induced NF‐κB activation

Z. Zhai, H. Shu, X. Hong, 2001 .

Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development.

D. Goeddel, T. Mak, A. Wakeham, 2000, Immunity.

Delicate regulation of the cGAS–MITA-mediated innate immune response

H. Shu, Wei-Wei Luo, 2018, Cellular & Molecular Immunology.

Duck Tembusu Virus Nonstructural Protein 1 Antagonizes IFN-β Signaling Pathways by Targeting VISA

Yan Zeng, H. Shu, Yujie Ren, 2016, The Journal of Immunology.

MITA/STING: A central and multifaceted mediator in innate immune response

H. Shu, Yan-Yi Wang, Yong Ran, 2014, Cytokine & Growth Factor Reviews.

MLL1/WDR5 complex in leukemogenesis and epigenetic regulation

H. Shu, Min Wu, H. Shu, 2011, Chinese journal of cancer.

Human Cytomegalovirus Tegument Protein UL 82 Inhibits STING-Mediated Signaling to Evade Antiviral Immunity Graphical

M. Luo, H. Shu, Shu Li, 2017 .

Human Cytomegalovirus Tegument Protein UL82 Inhibits STING-Mediated Signaling to Evade Antiviral Immunity.

M. Luo, H. Shu, Shu Li, 2017, Cell host & microbe.

RBCK1 Negatively Regulates Tumor Necrosis Factor- and Interleukin-1-triggered NF-κB Activation by Targeting TAB2/3 for Degradation*

Min Zhang, Bo Zhong, Yan Zhang, 2007, Journal of Biological Chemistry.

MARCH3 attenuates IL-1β–triggered inflammation by mediating K48-linked polyubiquitination and degradation of IL-1RI

H. Shu, Shu Li, Y. Liu, 2018, Proceedings of the National Academy of Sciences.

TRIM38 inhibits TNFα- and IL-1β–triggered NF-κB activation by mediating lysosome-dependent degradation of TAB2/3

H. Shu, Yan-Yi Wang, Bo Zhong, 2014, Proceedings of the National Academy of Sciences.

The E3 ubiquitin ligase MARCH8 negatively regulates IL-1β-induced NF-κB activation by targeting the IL1RAP coreceptor for ubiquitination and degradation

H. Shu, Qian Zhou, Yu Zhang, 2012, Proceedings of the National Academy of Sciences.

The Ret Finger Protein Inhibits Signaling Mediated by the Noncanonical and Canonical IκB Kinase Family Members1

Z. Zhai, H. Shu, Liang-Guo Xu, 2006, The Journal of Immunology.

E3 ligase WWP2 negatively regulates TLR3-mediated innate immune response by targeting TRIF for ubiquitination and degradation

H. Shu, Yan-Yi Wang, Ying Jin, 2013, Proceedings of the National Academy of Sciences.

Analysis of a TIR-less Splice Variant of TRIF Reveals an Unexpected Mechanism of TLR3-mediated Signaling*

H. Shu, Liang-Guo Xu, Ke-jun Han, 2010, The Journal of Biological Chemistry.

Direct transfer of transforming growth factor beta 1 gene into arteries stimulates fibrocellular hyperplasia.

R. Derynck, E. Nabel, G. Nabel, 1993, Proceedings of the National Academy of Sciences of the United States of America.

KAT5 acetylates cGAS to promote innate immune response to DNA virus

H. Shu, Wei Guo, Ming-Ming Hu, 2020, Proceedings of the National Academy of Sciences.

USP2a negatively regulates IL-1β- and virus-induced NF-κB activation by deubiquitinating TRAF6.

H. Shu, Xiao He, Xiao-Dong Zhang, 2013, Journal of molecular cell biology.

USP 2 a negatively regulates IL-1 band virus-induced NFk B activation by deubiquitinating TRAF 6

H. Shu, Xiao He, Xiao-Dong Zhang, 2013 .

Modulation of innate immune response to viruses including SARS-CoV-2 by progesterone

H. Shu, K. Lan, Ming-Ming Hu, 2022, Signal Transduction and Targeted Therapy.

Regulation of tubulin synthesis and cell cycle progression in mammalian cells by γ‐tubulin‐mediated microtubule nucleation

Jun Zhou, H. Joshi, H. Shu, 2002, Journal of cellular biochemistry.

The CXXC finger 5 protein is required for DNA damage-induced p53 activation

Min Zhang, Z. Zhai, H. Shu, 2009, Science in China Series C: Life Sciences.

Phosphorylation of cGAS by CDK1 impairs self-DNA sensing in mitosis

Y. Liu, H. Shu, Ming-Ming Hu, 2020, Cell Discovery.

Quantitative Proteomics Identified TTC4 as a TBK1 Interactor and a Positive Regulator of SeV‐Induced Innate Immunity

Lin Guo, H. Shu, Tian Xia, 2018, Proteomics.

GIDE is a mitochondrial E3 ubiquitin ligase that induces apoptosis and slows growth

Z. Zhai, H. Shu, Liang-Guo Xu, 2008, Cell Research.

TRAF7 Potentiates MEKK3-induced AP1 and CHOP Activation and Induces Apoptosis*

H. Shu, Liang-Guo Xu, Lianyun Li, 2004, Journal of Biological Chemistry.

Activation of NF-κB by FADD, Casper, and Caspase-8*

H. Shu, H. Johnson, Wenhui Hu, 2000, The Journal of Biological Chemistry.

USP19 Inhibits TNF-α– and IL-1β–Triggered NF-κB Activation by Deubiquitinating TAK1

H. Shu, Bo Zhong, Cao-Qi Lei, 2019, The Journal of Immunology.

Krüppel-like Factor 6 Is a Co-activator of NF-κB That Mediates p65-dependent Transcription of Selected Downstream Genes*

H. Shu, Bo Zhong, Cao-Qi Lei, 2014, The Journal of Biological Chemistry.

VISA Is Required for B Cell Expression of TLR7

Lei Jin, H. Shu, Liang-Guo Xu, 2012, The Journal of Immunology.

The E3 ubiquitin ligase MIB1 negatively regulates basal IκBα level and modulates NF-κB activation

Y. Li, H. Shu, Yan-Yi Wang, 2011, Cell Research.

Tripartite motif 8 (TRIM8) modulates TNFα- and IL-1β–triggered NF-κB activation by targeting TAK1 for K63-linked polyubiquitination

H. Shu, Jie Yan, Yan-Yi Wang, 2011, Proceedings of the National Academy of Sciences.

Identification of RELT homologues that associate with RELT and are phosphorylated by OSR1.

H. Shu, Liang-Guo Xu, Liang-Hua Bin, 2006, Biochemical and biophysical research communications.

VRK2 is involved in the innate antiviral response by promoting mitostress-induced mtDNA release

H. Shu, Ming-Ming Hu, Wen-Rui He, 2021, Cellular & Molecular Immunology.

USP13 negatively regulates antiviral responses by deubiquitinating STING

Hong Wang, H. Shu, Bo Zhong, 2017, Nature Communications.

NIK is a component of the EGF/heregulin receptor signaling complexes

Z. Zhai, H. Shu, Liang-Guo Xu, 2003, Oncogene.

STUB1 is essential for T‐cell activation by ubiquitinating CARMA1

H. Shu, Yi Li, Yan Gao, 2013, European journal of immunology.

Identification of a ZU5 and death domain-containing inhibitor of NF-kappaB.

H. Shu, Liang-Guo Xu, Ke-jun Han, 2004, The Journal of biological chemistry.

Differential regulation of IKKα-mediated activation of IRF3/7 by NIK

Z. Zhai, H. Shu, Feici Diao, 2008 .

SNX8 modulates the innate immune response to RNA viruses by regulating the aggregation of VISA

H. Shu, W. Guo, Shu Li, 2019, Cellular & Molecular Immunology.

The Zinc‐Finger Protein ZCCHC3 Binds RNA and Facilitates Viral RNA Sensing and Activation of the RIG‐I‐like Receptors

H. Shu, Shu Li, Cao-Qi Lei, 2018, Immunity.

Induction of USP25 by viral infection promotes innate antiviral responses by mediating the stabilization of TRAF3 and TRAF6

H. Shu, Min Wu, Yujie Ren, 2015, Proceedings of the National Academy of Sciences.

ZDHHC11 modulates innate immune response to DNA virus by mediating MITA–IRF3 association

H. Shu, Shu Li, Qian Zhou, 2018, Cellular & Molecular Immunology.

USP2a positively regulates TCR-induced NF-κB activation by bridging MALT1-TRAF6

H. Shu, Xiao He, Yi Li, 2012, Protein & Cell.

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

Mark R. Marten, Erinna F. Lee, Dana L. Miller, 2021, Autophagy.

Lymphoma cell adhesion-induced expression of B cell-activating factor of the TNF family in bone marrow stromal cells protects non-Hodgkin's B lymphoma cells from apoptosis

J. Tao, H. Shu, L. Moscinski, 2009, Leukemia.

Casper/c-FLIP is physically and functionally associated with NF-κB1 p105

H. Shu, Zhiqin Li, Dan-Ying Chen, 2003 .

The p53-inducible apoptotic protein AMID is not required for normal development and tumor suppression

H. Shu, J. Mei, B. Zhang, 2006, Oncogene.

TRIM38 Negatively Regulates TLR3/4-Mediated Innate Immune and Inflammatory Responses by Two Sequential and Distinct Mechanisms

H. Shu, Qing Yang, Ming-Ming Hu, 2015, The Journal of Immunology.

MSX1 Modulates RLR-Mediated Innate Antiviral Signaling by Facilitating Assembly of TBK1-Associated Complexes

H. Shu, Ming-Ming Hu, Zhi-Sheng Xu, 2016, The Journal of Immunology.

The membrane-associated ubiquitin ligases MARCH2 and MARCH3 target IL-5 receptor alpha to negatively regulate eosinophilic airway inflammation

R. Liu, H. Shu, Shu Li, 2022, Cellular & Molecular Immunology.

mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis

R. Liu, H. Shu, Shu Li, 2021, Nature Communications.

Resistance to Inhibitors of Cholinesterase-8A (Ric-8A) Is Critical for Growth Factor Receptor-induced Actin Cytoskeletal Reorganization*

H. Shu, Bowen Xing, Xin-Yun Huang, 2011, The Journal of Biological Chemistry.

Syntenin negatively regulates TRAF6-mediated IL-1R/TLR4 signaling.

Min Zhang, Z. Zhai, H. Shu, 2008, Cellular signalling.

ZCCHC3 modulates TLR3-mediated signaling by promoting recruitment of TRIF to TLR3

Q. Yang, H. Shu, Xuan Zhong, 2020, Journal of molecular cell biology.

TRIM32-TAX1BP1-dependent selective autophagic degradation of TRIF negatively regulates TLR3/4-mediated innate immune responses

H. Shu, Bo Zhong, Qing Yang, 2017, PLoS pathogens.

TRIM8 Negatively Regulates TLR3/4-Mediated Innate Immune Response by Blocking TRIF–TBK1 Interaction

H. Shu, Qian Zhou, Cao-Qi Lei, 2017, The Journal of Immunology.

TTDN1 is a Plk1-interacting protein involved in maintenance of cell cycle integrity

H. Shu, D. Chen, Y. Tian, 2007, Cellular and Molecular Life Sciences.

Virus-induced accumulation of intracellular bile acids activates the TGR5-β-arrestin-SRC axis to enable innate antiviral immunity

H. Shu, Shu Li, Qing Yang, 2019, Cell Research.

Transmembrane Protein 214 (TMEM214) Mediates Endoplasmic Reticulum Stress-induced Caspase 4 Enzyme Activation and Apoptosis*

Y. Liu, Y. Li, H. Shu, 2013, The Journal of Biological Chemistry.

Linear ubiquitination of NEMO brakes the antiviral response.

H. Shu, Yan-Yi Wang, Yong Ran, 2012, Cell host & microbe.

MITA/STING-mediated antiviral immunity and autoimmunity: the evolution, mechanism, and intervention.

H. Shu, Bo Zhong, 2022, Current opinion in immunology.

Epigenetic Dysregulation Induces Translocation of Histone H3 into Cytoplasm

H. Shu, Bo Zhong, Zhiyin Song, 2021, Advanced science.

Endocytosis triggers V-ATPase-SYK–mediated priming of cGAS activation and innate immune response

H. Shu, Ming-Ming Hu, Qing Yang, 2022, Proceedings of the National Academy of Sciences of the United States of America.

TMED2 Potentiates Cellular IFN Responses to DNA Viruses by Reinforcing MITA Dimerization and Facilitating Its Trafficking.

H. Shu, Chao Shen, Li-Qun Jiang, 2018, Cell reports.

Activation of NF-kappaB by FADD, Casper, and caspase-8.

H. Shu, H. Johnson, W. Hu, 2000, The Journal of biological chemistry.

Death-associated protein kinase 1 is an IRF3/7-interacting protein that is involved in the cellular antiviral immune response

H. Shu, Shu Li, Ming-Ming Hu, 2014, Cellular and Molecular Immunology.

Protein Kinase C-δ Negatively Regulates T Cell Receptor-induced NF-κB Activation by Inhibiting the Assembly of CARMA1 Signalosome*

H. Shu, Yi Li, Yan Gao, 2012, The Journal of Biological Chemistry.

PIASy represses TRIF-induced ISRE and NF-kappaB activation but not apoptosis.

Xudong Wei, H. Shu, Liang-Guo Xu, 2004, FEBS letters.

RNF26 Temporally Regulates Virus-Triggered Type I Interferon Induction by Two Distinct Mechanisms

Lin Guo, H. Shu, Bo Zhong, 2014, PLoS pathogens.

Ubiquitination and Degradation Virus-Induced Signaling Adaptor for The E3 Ubiquitin Ligase RNF5 Targets

H. Shu, Bo Zhong, Yu Zhang, 2010 .

Cytoplasmic Mechanisms of Recognition and Defense of Microbial Nucleic Acids.

H. Shu, Ming-Ming Hu, 2018, Annual review of cell and developmental biology.

RIP5 is a RIP-homologous inducer of cell death.

Z. Zhai, H. Shu, Liang-Guo Xu, 2004, Biochemical and biophysical research communications.

Extracellular signal-regulated kinase, receptor interacting protein, and reactive oxygen species regulate shikonin-induced autophagy in human hepatocellular carcinoma.

Ke Gong, H. Shu, Wenhua Li, 2014, European journal of pharmacology.

Casper is a FADD- and caspase-related inducer of apoptosis.

D. Goeddel, H. Shu, D. Goeddel, 1997, Immunity.

The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation.

Y. Li, P. Tien, H. Shu, 2008, Immunity.

MARCH3 negatively regulates IL-3-triggered inflammatory response by mediating K48-linked polyubiquitination and degradation of IL-3Rα

H. Shu, Shu Li, Chen Li, 2022, Signal Transduction and Targeted Therapy.

Gamma-tubulin can both nucleate microtubule assembly and self-assemble into novel tubular structures in mammalian cells

H. Joshi, H. Shu, 1995, The Journal of cell biology.

Heat shock protein 90 is involved in regulation of hypoxia-driven proliferation of embryonic neural stem/progenitor cells

H. Shu, Ming-ming Li, T. Zhao, 2009, Cell Stress and Chaperones.

Gene expression atlas for human embryogenesis

Yun-Bo Shi, Hong-Bing Shu, H. Shu, 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Regulation of Virus-triggered Signaling by OTUB1- and OTUB2-mediated Deubiquitination of TRAF3 and TRAF6*

Y. Li, P. Tien, H. Shu, 2009, The Journal of Biological Chemistry.

Negative feedback regulation of cellular antiviral signaling by RBCK1-mediated degradation of IRF3

Min Zhang, Z. Zhai, H. Shu, 2008, Cell Research.

VISA Is an Adapter Protein Required for Virus-Triggered IFN-β Signaling

Z. Zhai, H. Shu, Liang-Guo Xu, 2005 .

VISA is an adapter protein required for virus-triggered IFN-beta signaling.

Z. Zhai, H. Shu, Liang-Guo Xu, 2005, Molecular cell.

The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex.

D. Goeddel, H. Shu, M. Takeuchi, 1996, Proceedings of the National Academy of Sciences of the United States of America.

USP2a positively regulates TCR-induced NF-κB activation by bridging MALT1-TRAF6

H. Shu, Yi Li, Yu Liu, 2012, Protein & Cell.

ZDHHC11 modulates innate immune response to DNA virus by mediating MITA–IRF3 association

H. Shu, Shu Li, Qian Zhou, 2018, Cellular & Molecular Immunology.

Identification of a nuclear protein that promotes NF-κB activation

Z. Zhai, H. Shu, Qian Yang, 2003 .

A Novel Zinc Finger Protein Interacts with Receptor-interacting Protein (RIP) and Inhibits Tumor Necrosis Factor (TNF)- and IL1-induced NF-κB Activation*

Z. Zhai, H. Shu, Xiaoyan Li, 2002, The Journal of Biological Chemistry.

TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex.

D. Goeddel, H. Shu, D. Goeddel, 1996, Immunity.

Reduced competitiveness of autoantigen-engaged B cells due to increased dependence on BAFF.

J. Cyster, H. Shu, S. Kalled, 2004, Immunity.

TIRP, a Novel Toll/Interleukin-1 receptor (TIR) Domain-containing Adapter Protein Involved in TIR Signaling*

H. Shu, Liang-Guo Xu, Liang-Hua Bin, 2003, Journal of Biological Chemistry.

iRhom2 is essential for innate immunity to DNA viruses by mediating trafficking and stability of the adaptor STING

H. Shu, Shu Li, Bo Zhong, 2016, Nature Immunology.

Regulation of IRF2 transcriptional activity by its sumoylation.

H. Shu, Ling-ling Jiang, Ke-jun Han, 2008, Biochemical and biophysical research communications.

SINK is a p65-interacting negative regulator of NF-kappaB-dependent transcription.

Z. Zhai, H. Shu, Liang-Guo Xu, 2003, The Journal of biological chemistry.

The tumor suppressor PTEN has a critical role in antiviral innate immunity

Yuxin Yin, E. Jokitalo, H. Shu, 2015, Nature Immunology.

A transient association of gamma-tubulin at the midbody is required for the completion of cytokinesis during the mammalian cell division.

Q. Li, H. Joshi, H. Shu, 1995, Journal of cell science.

The p53‐inducible E3 ubiquitin ligase p53RFP induces p53‐dependent apoptosis

Z. Zhai, H. Shu, Liang-Guo Xu, 2006, FEBS letters.

Glycogen synthase kinase 3β regulates IRF3 transcription factor-mediated antiviral response via activation of the kinase TBK1.

H. Shu, Bo Zhong, Cao-Qi Lei, 2010, Immunity.

SINK Is a p65-interacting Negative Regulator of NF-κB-dependent Transcription*

Z. Zhai, H. Shu, Liang-Guo Xu, 2003, Journal of Biological Chemistry.

β-adrenoreceptor-triggered PKA activation negatively regulates the innate antiviral response

H. Shu, Ming-Ming Hu, S. Su, 2023, Cellular & Molecular Immunology.

The membrane-associated E3 ubiquitin ligase MARCH3 downregulates the IL-6 receptor and suppresses colitis-associated carcinogenesis

H. Shu, Shu Li, Heng Lin, 2021, Cellular & Molecular Immunology.

Mitotic inactivation of the cGAS‒MITA/STING pathways

H. Shu, Li Zhong, 2021, Journal of molecular cell biology.

PCBP1 modulates the innate immune response by facilitating the binding of cGAS to DNA

H. Shu, Cao-Qi Lei, Chen-Yang Liao, 2020, Cellular & Molecular Immunology.

PCBP1 modulates the innate immune response by facilitating the binding of cGAS to DNA

H. Shu, Cao-Qi Lei, Chen-Yang Liao, 2020, Cellular & Molecular Immunology.

Deciphering the pathways to antiviral innate immunity and inflammation.

H. Shu, Qing Yang, 2020, Advances in immunology.

PTPN1/2-mediated dephosphorylation of MITA/STING promotes its 20S proteasomal degradation and attenuates innate antiviral response

H. Shu, Tian Xia, Xue-Mei Yi, 2019, Proceedings of the National Academy of Sciences.

The zinc-finger protein ZFYVE1 modulates TLR3-mediated signaling by facilitating TLR3 ligand binding

H. Shu, Cao-Qi Lei, Yi Ding, 2019, Cellular & Molecular Immunology.

SNX8 modulates innate immune response to DNA virus by mediating trafficking and activation of MITA

H. Shu, W. Guo, Shu Li, 2018, PLoS pathogens.

ZCCHC3 is a co-sensor of cGAS for dsDNA recognition in innate immune response

H. Shu, Shu Li, Cao-Qi Lei, 2018, Nature Communications.

SNX8 mediates IFNγ-triggered noncanonical signaling pathway and host defense against Listeria monocytogenes

H. Shu, W. Guo, Shu Li, 2017, Proceedings of the National Academy of Sciences.

iRhom2 is essential for innate immunity to RNA virus by antagonizing ER- and mitochondria-associated degradation of VISA

H. Shu, Shu Li, Yan-Yi Wang, 2017, PLoS pathogens.

Emerging roles of rhomboid‐like pseudoproteases in inflammatory and innate immune responses

H. Shu, Wei-Wei Luo, 2017, FEBS letters.

SPI-2/CrmA inhibits IFN-β induction by targeting TBK1/IKKε

W. Yin, Z. Bian, H. Shu, 2017, Scientific Reports.

PKACs attenuate innate antiviral response by phosphorylating VISA and priming it for MARCH5-mediated degradation

H. Shu, Bing-Ru Yan, Yan-Yi Wang, 2017, PLoS pathogens.

Multifaceted roles of TRIM38 in innate immune and inflammatory responses

H. Shu, Ming-Ming Hu, 2017, Cellular & Molecular Immunology.

Adding to the STING.

H. Shu, Yan-Yi Wang, 2014, Immunity.

TRIM32 Protein Modulates Type I Interferon Induction and Cellular Antiviral Response by Targeting MITA/STING Protein for K63-linked Ubiquitination*

H. Shu, Yan-Yi Wang, Ming-Ming Hu, 2012, The Journal of Biological Chemistry.

LSm14A is a processing body-associated sensor of viral nucleic acids that initiates cellular antiviral response in the early phase of viral infection

H. Shu, Qian Zhou, Xiao-Dong Zhang, 2012, Proceedings of the National Academy of Sciences of the United States of America.

The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA.

Y. Li, H. Shu, Yan-Yi Wang, 2009, Immunity.

FAM64A positively regulates STAT3 activity to promote Th17 differentiation and colitis-associated carcinogenesis

H. Xia, H. Shu, Min Wu, 2019, Proceedings of the National Academy of Sciences.

TRIM27 mediates STAT3 activation at retromer-positive structures to promote colitis and colitis-associated carcinogenesis

H. Shu, Yan-Yi Wang, Tian Xia, 2018, Nature Communications.

PASD1 promotes STAT3 activity and tumor growth by inhibiting TC45-mediated dephosphorylation of STAT3 in the nucleus.

H. Shu, Yan-Yi Wang, Yong Ran, 2016, Journal of molecular cell biology.

dephosphorylation of STAT3 in the nucleus

H. Shu, Yan-Yi Wang, Yong Ran, 2016 .

USP18 recruits USP20 to promote innate antiviral response through deubiquitinating STING/MITA

Lei Yuan, H. Shu, Dong-er Zhang, 2016, Cell Research.

Hydrogen peroxide detection with high specificity in living cells and inflamed tissues

H. Shu, Jun Feng, Qi Lei, 2016, Regenerative biomaterials.

Sumoylation Promotes the Stability of the DNA Sensor cGAS and the Adaptor STING to Regulate the Kinetics of Response to DNA Virus.

H. Shu, Ming-Ming Hu, Tian-Tian Liu, 2016, Immunity.

ISG56 is a negative-feedback regulator of virus-triggered signaling and cellular antiviral response

H. Shu, Yan-Yi Wang, Bo Zhong, 2009, Proceedings of the National Academy of Sciences.

Regulation of virus-triggered type I interferon signaling by cellular and viral proteins

H. Shu, Yan-Yi Wang, Bo Zhong, 2010, Frontiers in Biology.

Crystal structure of ISG54 reveals a novel RNA binding structure and potential functional mechanisms

Y. Li, Huanhuan Liang, H. Shu, 2012, Cell Research.

The Membrane-Associated MARCH E3 Ligase Family: Emerging Roles in Immune Regulation

H. Shu, Shu Li, Heng Lin, 2019, Front. Immunol..

DNA-PK deficiency potentiates cGAS-mediated antiviral innate immunity

H. Shu, Jun Zhao, P. Feng, 2020, Nature Communications.

Quantitative Proteomics Reveals the Roles of Peroxisome-associated Proteins in Antiviral Innate Immune Responses*

Xi Chen, Lin Guo, H. Shu, 2015, Molecular & Cellular Proteomics.

ISG60 negatively regulates cell antiviral responses by disrupting the VISA-associated complexes

Y. Li, H. Shu, Weiping Zhang, 2012, Wuhan University Journal of Natural Sciences.

I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction.

D. Goeddel, A. Goddard, H. Shu, 1996, Proceedings of the National Academy of Sciences of the United States of America.

SIKE is an IKKε/TBK1‐associated suppressor of TLR3‐ and virus‐triggered IRF‐3 activation pathways

Jun Huang, Liang-Guo Xu, Hong-Bing Shu, 2005 .

SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways.

Jun Huang, Liang-Guo Xu, Hong-Bing Shu, 2005, The EMBO journal.

Identification of a nuclear protein that promotes NF-kappaB activation.

Z. Zhai, H. Shu, Qian Yang, 2003, Biochemical and biophysical research communications.

Negative regulation of MDA5- but not RIG-I-mediated innate antiviral signaling by the dihydroxyacetone kinase

Z. Zhai, P. Tien, H. Shu, 2007, Proceedings of the National Academy of Sciences.

Methylation analyses on promoters of mPer1, mPer2, and mCry1 during perinatal development.

H. Shu, Xiaodong Li, Yue Qin, 2010, Biochemical and biophysical research communications.

TRIP6 is a RIP2-associated common signaling component of multiple NF-κB activation pathways

Z. Zhai, H. Shu, Liang-Hua Bin, 2005, Journal of Cell Science.

TNFR-Associated Factor-3 Is Associated With BAFF-R and Negatively Regulates BAFF-R-Mediated NF-κB Activation and IL-10 Production

H. Shu, Liang-Guo Xu, 2002, The Journal of Immunology.

TALL‐1 is a novel member of the TNF family that is down‐regulated by mitogens

H. Shu, H. Johnson, Wenbin Hu, 1999, Journal of leukocyte biology.

AMID, an Apoptosis-inducing Factor-homologous Mitochondrion-associated Protein, Induces Caspase-independent Apoptosis*

Z. Zhai, H. Shu, Liang-Guo Xu, 2002, The Journal of Biological Chemistry.

AMID is a p53-inducible gene downregulated in tumors

Z. Zhai, H. Shu, Liang-Guo Xu, 2004, Oncogene.

Mechanisms of the TRIF-induced Interferon-stimulated Response Element and NF-κB Activation and Apoptosis Pathways*

H. Shu, Liang-Guo Xu, Liang-Hua Bin, 2004, Journal of Biological Chemistry.

Characterization of the carbonic anhydrases 15b expressed in PGCs during early zebrafish development.

H. Shu, B. Wang, H. Wang, 2013, Theriogenology.

USP8 inhibition reshapes an inflamed tumor microenvironment that potentiates the immunotherapy

G. Freeman, Xueliang Gao, Haizhen Wang, 2022, Nature Communications.

The Type I Interferon-IRF7 Axis Mediates Transcriptional Expression of Usp25 Gene*

Ximing Xu, H. Shu, Yujie Ren, 2016, The Journal of Biological Chemistry.

The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling

R. Chen, H. Shu, Bo Zhong, 2010, Cell Research.

The epigenetic landscapes of histone modifications on HSV-1 genome in human THP-1 cells.

H. Shu, Lin Chen, Min Wu, 2020, Antiviral research.

Phosphorylation of cGAS by CDK1 impairs self-DNA sensing in mitosis

H. Shu, Ming-Ming Hu, Qiang Chen, 2020, Cell Discovery.

Dephosphorylation of cGAS by PPP6C impairs its substrate binding activity and innate antiviral response

H. Shu, Mi Li, 2020, Protein & Cell.

TNF receptor‐associated factor‐1 (TRAF1) negatively regulates Toll/IL‐1 receptor domain‐containing adaptor inducing IFN‐β (TRIF)‐mediated signaling

Z. Zhai, H. Shu, Wanqiang Qian, 2006, European journal of immunology.

Regulation of TRIF-mediated innate immune response by K27-linked polyubiquitination and deubiquitination

H. Shu, Cao-Qi Lei, Tian Xia, 2019, Nature Communications.

ECSIT Bridges RIG-I-Like Receptors to VISA in Signaling Events of Innate Antiviral Responses

H. Shu, Yong Ho Kim, Bo Zhong, 2014, Journal of Innate Immunity.

Innate immune responses: crosstalk of signaling and regulation of gene transcription.

Bo Zhong, Hong-Bing Shu, P. Tien, 2006, Virology.

PIASy represses TRIF‐induced ISRE and NF‐κB activation but not apoptosis

Xudong Wei, H. Shu, Liang-Guo Xu, 2004 .

Innate immunity to RNA virus is regulated by temporal and reversible sumoylation of RIG-I and MDA5

H. Shu, Ming-Ming Hu, Qing Yang, 2017, The Journal of experimental medicine.

TRIM4 modulates type I interferon induction and cellular antiviral response by targeting RIG-I for K63-linked ubiquitination.

H. Shu, Jie Yan, Ming-Ming Hu, 2014, Journal of molecular cell biology.

IFITM3 inhibits virus-triggered induction of type I interferon by mediating autophagosome-dependent degradation of IRF3

H. Shu, Cao-Qi Lei, Tian Xia, 2017, Cellular & Molecular Immunology.

Differential regulation of vascular cell adhesion molecule 1 gene expression by specific NF-kappa B subunits in endothelial and epithelial cells

E. Nabel, G. Nabel, K. Leung, 1993, Molecular and cellular biology.

The short splice form of Casper/c‐FLIP is a major cellular inhibitor of TRAIL‐induced apoptosis

H. Shu, Liang-Guo Xu, Xiaoyan Li, 2002, FEBS letters.

SENP2 negatively regulates cellular antiviral response by deSUMOylating IRF3 and conditioning it for ubiquitination and degradation.

Y. Li, H. Shu, Shu Li, 2011, Journal of molecular cell biology.

SENP 2 negatively regulates cellular antiviral response by deSUMOylating IRF 3 and conditioning it for ubiquitination and degradation

H. Shu, Shu Li, Qian Zhou, 2011 .

TARBP2 negatively regulates IFN‐&bgr; production and innate antiviral response by targeting MAVS

H. Shu, Liang-Guo Xu, T. Ling, 2018, Molecular immunology.

Tumor Necrosis Factor-related Apoptosis-inducing Ligand Receptors Signal NF-κB and JNK Activation and Apoptosis through Distinct Pathways*

H. Shu, H. Johnson, W. Hu, 1999, The Journal of Biological Chemistry.

Identification of a ZU5 and Death Domain-containing Inhibitor of NF-κB*

H. Shu, Liang-Guo Xu, Ke-jun Han, 2004, Journal of Biological Chemistry.

Virus-triggered Ubiquitination of TRAF3/6 by cIAP1/2 Is Essential for Induction of Interferon-β (IFN-β) and Cellular Antiviral Response*

Y. Li, H. Shu, Jie Yan, 2010, The Journal of Biological Chemistry.

Foot-and-mouth disease virus structural protein VP3 degrades Janus kinase 1 to inhibit IFN-γ signal transduction pathways

Zixiang Zhu, H. Shu, Shu Li, 2016, Cell cycle.

The RNA-binding protein LUC7L2 mediates MITA/STING intron retention to negatively regulate innate antiviral response

H. Shu, Cao-Qi Lei, Wei-Wei Luo, 2021, Cell discovery.

LSm14A Plays a Critical Role in Antiviral Immune Responses by Regulating MITA Level in a Cell-Specific Manner

H. Shu, Yan-Yi Wang, Bo Zhong, 2016, The Journal of Immunology.

Krüppel-like factor 4 negatively regulates cellular antiviral immune response

H. Shu, Shu Li, Bo Zhong, 2014, Cellular and Molecular Immunology.

Hepatitis C virus NS4B blocks the interaction of STING and TBK1 to evade host innate immunity.

N. Kato, H. Shu, Q. Ding, 2013, Journal of hepatology.

WDR5 is essential for assembly of the VISA-associated signaling complex and virus-triggered IRF3 and NF-κB activation

P. Tien, H. Shu, Shu Li, 2009, Proceedings of the National Academy of Sciences.

Innate Immune Response to Cytoplasmic DNA: Mechanisms and Diseases.

H. Shu, Ming-Ming Hu, 2019, Annual review of immunology.

Dephosphorylation of cGAS by PPP6C impairs its substrate binding activity and innate antiviral response

H. Shu, Mi Li, 2020, Protein & Cell.

RACK1 attenuates RLR antiviral signaling by targeting VISA-TRAF complexes.

Q. Yang, H. Shu, Liang-Guo Xu, 2019, Biochemical and biophysical research communications.

Reciprocal regulation of IL-33 receptor–mediated inflammatory response and pulmonary fibrosis by TRAF6 and USP38

H. Shu, Shu Li, Mi Li, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Collagenous Structure as a Lung-Specific 1 and Macrophage Scavenger Receptor with Identification of Uteroglobin-Related Protein

Hong-Bing Shu, Larry D. Nielson, Xinqi Liu, 2013 .

Parafibromin Is a Component of IFN-γ–Triggered Signaling Pathways That Facilitates JAK1/2-Mediated Tyrosine Phosphorylation of STAT1

H. Shu, Bo Zhong, Jin Wei, 2015, The Journal of Immunology.

CSK promotes innate immune response to DNA virus by phosphorylating MITA.

H. Shu, Ming-Ming Hu, Peng Gao, 2020, Biochemical and biophysical research communications.

The ER-associated protein ZDHHC1 is a positive regulator of DNA virus-triggered, MITA/STING-dependent innate immune signaling.

Y. Liu, H. Shu, Yan-Yi Wang, 2014, Cell host & microbe.

Heat shock cognate 71 (HSC71) regulates cellular antiviral response by impairing formation of VISA aggregates

H. Shu, Shu Wu, Shu Li, 2013, Protein & Cell.

A20 is a potent inhibitor of TLR3- and Sendai virus-induced activation of NF-kappaB and ISRE and IFN-beta promoter.

Hong-Bing Shu, Z. Zhai, H. Shu, 2004, FEBS letters.

Direct transfer of transforming growth factor j81 gene into arteries stimulates fibrocellular hyperplasia (gene transfer/gene expression/extraceliular matrix/ceilular proliferation)

R. Derynck, E. Nabel, G. Nabel, 2005 .

The E3 Ubiquitin Ligase RNF5 Targets Virus-Induced Signaling Adaptor for Ubiquitination and Degradation

H. Shu, Yan-Yi Wang, Bo Zhong, 2010, The Journal of Immunology.

DYRK2 Negatively Regulates Type I Interferon Induction by Promoting TBK1 Degradation via Ser527 Phosphorylation

P. Tien, H. Shu, W. Pan, 2015, PLoS pathogens.

Identification of a novel serine/threonine kinase that inhibits TNF-induced NF-kappaB activation and p53-induced transcription.

Z. Zhai, H. Shu, Liang-Guo Xu, 2003, Biochemical and biophysical research communications.

Virus-induced accumulation of intracellular bile acids activates the TGR5-β-arrestin-SRC axis to enable innate antiviral immunity

H. Shu, Shu Li, Ming-Ming Hu, 2019, Cell Research.

WDFY1 mediates TLR3/4 signaling by recruiting TRIF

H. Shu, Cao-Qi Lei, Yu Zhang, 2015, EMBO reports.

Delicate regulation of the cGAS–MITA-mediated innate immune response

H. Shu, Wei-Wei Luo, 2018, Cellular & Molecular Immunology.

ZNF216 Is an A20-like and IkappaB kinase gamma-interacting inhibitor of NFkappaB activation.

Z. Zhai, H. Shu, Liang-Guo Xu, 2004, The Journal of biological chemistry.

RELT family members activate p38 and induce apoptosis by a mechanism distinct from TNFR1.

John Cusick, Liang-Guo Xu, Hong-Bing Shu, 2017, Biochemical and biophysical research communications.

A Naturally Occurring Deletion in the Effector Domain of H5N1 Swine Influenza Virus Nonstructural Protein 1 Regulates Viral Fitness and Host Innate Immunity

Hualan Chen, Yan Zeng, H. Shu, 2018, Journal of Virology.

RAVER1 is a coactivator of MDA5-mediated cellular antiviral response.

Y. Li, H. Shu, Jing Zhang, 2013, Journal of molecular cell biology.

Differential regulation of IKK alpha-mediated activation of IRF3/7 by NIK.

Min Zhang, Y. Li, Z. Zhai, 2008, Molecular immunology.

The Dual-specificity Phosphatase DUSP14 Negatively Regulates Tumor Necrosis Factor- and Interleukin-1-induced Nuclear Factor-κB Activation by Dephosphorylating the Protein Kinase TAK1*

R. Chen, H. Shu, Shu Li, 2012, The Journal of Biological Chemistry.

MLL1, a H3K4 methyltransferase, regulates the TNF&agr;-stimulated activation of genes downstream of NF-&kgr;B

A. Guo, H. Shu, Yifang Liao, 2012, Journal of Cell Science.

STING is a cell-intrinsic metabolic checkpoint restricting aerobic glycolysis by targeting HK2

H. Shu, K. Sun, P. Feng, 2023, Nature Cell Biology.

ZFYVE1 negatively regulates MDA5- but not RIG-I-mediated innate antiviral response

Q. Yang, H. Shu, Cao-Qi Lei, 2020, PLoS pathogens.

IFITM3 inhibits virus-triggered induction of type I interferon by mediating autophagosome-dependent degradation of IRF3

H. Shu, Cao-Qi Lei, Tian Xia, 2017, Cellular & Molecular Immunology.

DDB1 is a cellular substrate of NS3/4A protease and required for hepatitis C virus replication.

Xi Chen, Lin Guo, H. Shu, 2013, Virology.

DDB 1 is a cellular substrate of NS 3 / 4 A protease and required for hepatitis C virus replication

Xi Chen, Lin Guo, H. Shu, 2012 .