H. Koyama

Y. Shinohara, H. Koyama, N. Maeda, 2002, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Retardation of early‐onset PMA‐induced apoptosis in mouse neutrophils deficient in myeloperoxidase

H. Koyama, N. Maeda, Y. Aratani, 2001, Journal of leukocyte biology.

Role of myeloperoxidase in the neutrophil-induced oxidation of low density lipoprotein as studied by myeloperoxidase-knockout mouse.

T. Kodama, H. Koyama, N. Noguchi, 2000, Journal of biochemistry.

Characterization of the 3' untranslated region of mouse DNA topoisomerase IIalpha mRNA.

H. Koyama, N. Adachi, M. Kobayashi, 1998, Gene.

Two overlapping divergent transcription units in the human genome: the FEN1/C11orf10 locus.

M. Lieber, H. Koyama, N. Adachi, 2002, Omics : a journal of integrative biology.

Induction of hyaluronic acid synthetase activity in rat fibroblasts by medium change of confluent cultures

H. Koyama, M. Tomida, T. Ono, 1975, Journal of cellular physiology.

Highly proficient gene targeting by homologous recombination in the human pre-B cell line Nalm-6.

H. Koyama, N. Adachi, Aya Kurosawa, 2008, Methods in molecular biology.

Simple one-week method to construct gene-targeting vectors: application to production of human knockout cell lines.

H. Koyama, Sairei So, N. Adachi, 2006, BioTechniques.

Identification of a Mutated DNA Ligase IV Gene in the X-ray-hypersensitive Mutant SX10 of Mouse FM3A Cells*

M. Oshimura, H. Koyama, D. Ayusawa, 2001, The Journal of Biological Chemistry.

End extension repair of introduced targeting vectors mediated by homologous recombination in mammalian cells.

H. Koyama, Y. Aratani, R. Okazaki, 1992, Nucleic acids research.

Myeloperoxidase has Directly-opposed Effects on Nitration Reaction--Study on Myeloperoxidase-deficient Patient and Myeloperoxidase-knockout Mice

Kazuo Suzuki, H. Koyama, Y. Kameoka, 2003, Free radical research.

Establishment of Glucagon-producing Cells by Cell Hybridization

H. Koyama, A. Kawaoi, J. Ono, 1984, Diabetes.

Cell-cycle regulation of the DNA topoisomerase IIalpha promoter is mediated by proximal CCAAT boxes: possible involvement of acetylation.

H. Koyama, N. Adachi, K. Kohno, 2000, Gene.

Induction, by thymidylate stress, of genetic recombination as evidenced by deletion of a transferred genetic marker in mouse FM3A cells

T. Seno, H. Koyama, D. Ayusawa, 1986, Molecular and cellular biology.

Hyaluronic acid synthetase in cultured mammalian cells producing hyaluronic acid Oscillatory change during the growth phase and suppression by 5-bromodeoxyuridine

H. Koyama, M. Tomida, T. Ono, 1974 .

Contribution of Myeloperoxidase to Coronary Artery Vasculitis Associated with MPO-ANCA Production

Kazuo Suzuki, H. Koyama, N. Maeda, 2001, Inflammation.

p53 Deﬁciency Rescues Neuronal Apoptosis but Not Differentiation in DNA Polymerase (cid:2) -Deﬁcient Mice

H. Koyama, N. Niimi, Y. Aratani, 2004 .

In vitro hemopoiesis within a microenvironment created by MC3T3‐G2/PA6 preadipocytes

H. Koyama, Shigehisa Yamamoto, H. Sudo, 1984, Journal of cellular physiology.

Enforced cytokinesis without complete nuclear division in embryonic cells depleting the activity of DNA topoisomerase IIα

N. Akimitsu, H. Koyama, H. Hirai, 2003, Genes to cells : devoted to molecular & cellular mechanisms.

Absence of p53 enhances growth defects and etoposide sensitivity of human cells lacking the Bloom syndrome helicase BLM.

H. Koyama, Sairei So, N. Adachi, 2007, DNA and cell biology.

A new preadipose cell line derived from newborn mouse calvaria can promote the proliferation of pluripotent hemopoietic stem cells in vitro

H. Koyama, H. Kodama, Y. Amagai, 1982, Journal of cellular physiology.

Enhanced gene targeting efficiency by siRNA that silences the expression of the Bloom syndrome gene in human cells

H. Koyama, Sairei So, N. Adachi, 2006, Genes to cells : devoted to molecular & cellular mechanisms.

Genetic Interactions between BLM and DNA Ligase IV in Human Cells*

M. Lieber, H. Koyama, Sairei So, 2004, Journal of Biological Chemistry.

Impaired cell adhesion, apoptosis, and signaling in WASP gene-disrupted Nalm-6 pre-B cells and recovery of cell adhesion using a transducible form of WASp

T. Morio, S. Mizutani, H. Koyama, 2012, International Journal of Hematology.

Differential host susceptibility to pulmonary infections with bacteria and fungi in mice deficient in myeloperoxidase.

H. Koyama, N. Maeda, H. Watanabe, 2000, The Journal of infectious diseases.

Contribution of the myeloperoxidase-dependent oxidative system to host defence against Cryptococcus neoformans.

Haruo Watanabe, Kazuo Suzuki, H. Koyama, 2006, Journal of medical microbiology.

Targeted recombination with single-stranded DNA vectors in mammalian cells.

H. Koyama, K. Kusano, Y. Aratani, 1993, Nucleic acids research.

FEN1 Functions in Long Patch Base Excision Repair Under Conditions of Oxidative Stress in Vertebrate Cells

Samuel H. Wilson, K. Asagoshi, D. Kaufman, 2010, Molecular Cancer Research.

Phorbol Myristate Acetate Induces Neutrophil Death through Activation of p38 Mitogen-Activated Protein Kinase That Requires Endogenous Reactive Oxygen Species Other Than HOCl

H. Koyama, Takao Saito, Y. Aratani, 2005, Bioscience, biotechnology, and biochemistry.

Accumulation of DNA strand breaks during thymineless death in thymidylate synthase-negative mutants of mouse FM3A cells.

T. Seno, H. Koyama, D. Ayusawa, 1983, The Journal of biological chemistry.

Cell Cycle-Dependent Regulation of the Mouse DNA Topoisomerase IIα Gene Promoter

H. Koyama, Masao Kobayashi, N. Adachi, 1997 .

Vertebrate cells lacking FEN-1 endonuclease are viable but hypersensitive to methylating agents and H2O2.

H. Koyama, N. Adachi, Y. Matsuzaki, 2002, Nucleic acids research.

Earlier onset of neutrophil-mediated inflammation in the ultraviolet-exposed skin of mice deficient in myeloperoxidase and NADPH oxidase

H. Koyama, N. Maeda, Y. Aratani, 2006, Inflammation Research.

In vivo role of myeloperoxidase for the host defense.

Haruo Watanabe, M. Dinauer, Kazuo Suzuki, 2004, Japanese journal of infectious diseases.

Decreased topoisomerase IIα expression confers increased resistance to ICRF-193 as well as VP-16 in mouse embryonic stem cells

H. Koyama, Masao Kobayashi, N. Adachi, 2001 .

Hormonal responsiveness of a preadipose cell line derived from newborn mouse calvaria

H. Koyama, H. Kodama, Y. Amagai, 1982, Journal of cellular physiology.

Purification and characterization of adenine phosphoribosyltransferase from mouse mammary carcinoma FM3A cells in culture.

H. Koyama, I. Kaneko, G. Okada, 1986, Biochimica et biophysica acta.

Evidence for a role of vertebrate Rad52 in the repair of topoisomerase II-mediated DNA damage.

H. Koyama, N. Adachi, Susumu Iiizumi, 2005, DNA and cell biology.

Effects of DNA topoisomerase inhibitors on nonhomologous and homologous recombination in mammalian cells.

H. Koyama, T. Andoh, Y. Aratani, 1996, Mutation research.

Establishment and characterization of a cell line from the american opossum (Didelphys virginiana)

A. Riggs, H. Koyama, R. Teplitz, 1978, In Vitro.

The enhanced production of hyaluronic acid by cultured rat fibroblast cells treated with cyclic AMP and its dibutyryl derivative

H. Koyama, M. Tomida, T. Ono, 1976, Journal of cellular physiology.

Development of cellular polarity of hamster embryos during compaction.

H. Koyama, X. Yang, T. Azuma, 1999, Biology of reproduction.

Further studies on the induction of alkaline phosphatase by 5-bromodeoxyuridine in a hybrid line between mouse and Chinese hamster in culture.

H. Koyama, T. Ono, 1972, Biochimica et biophysica acta.

Induction of alkaline phosphatase by 5-bromodeoxyuridine in a hybrid line between mouse and Chinese hamster in culture.

H. Koyama, T. Ono, 1971, Experimental cell research.

Effect of 5‐bromodeoxyuridine on hyaluronic acid synthesis of a clonal hybrid line of mouse and Chinese hamster in culture

H. Koyama, T. Ono, T. Ono, 1971, Journal of cellular physiology.

Isolation and characterization of mutator mutants from cultured mouse FM3A cells.

H. Koyama, M. Hyodo, K. Suzuki, 1984, Mutation research.

Tunicamycin-resistant mutations in mouse FM3A cells.

H. Koyama, D. Ayusawa, A. Takatsuki, 1982, Mutation research.

Analysis of the susceptibility of CD57+ T cells to CD3‐mediated apoptosis

N. Shinomiya, H. Koyama, E. Takayama, 2005, Clinical and experimental immunology.

Thymidineless death and mutation induction in cultured mouse FM3A cell mutants deficient in thymidylate synthase.

T. Seno, H. Koyama, D. Ayusawa, 1982, Mutation research.

Single-step selection of mouse FM3A cell mutants defective in thymidylate synthetase

T. Seno, H. Koyama, D. Ayusawa, 1980, Somatic cell genetics.

Initiation of a differentiated function (hyaluronic acid synthesis) by hybrid formation in culture.

H. Koyama, T. Ono, 1970, Biochimica et Biophysica Acta.

Loss of Nonhomologous End Joining Confers Camptothecin Resistance in DT40 Cells

H. Koyama, Sairei So, N. Adachi, 2004, Journal of Biological Chemistry.

A serum factor capable of stimulating hyaluronic acid synthesis in cultured rat fibroblasts

H. Koyama, M. Tomida, T. Ono, 1977, Journal of cellular physiology.

Induction of alkaline phosphatase by cyclic AMP or its dibutyryl derivative in a hybrid line between mouse and Chinese hamster in culture.

H. Koyama, T. Ono, R. Kato, 1972, Biochemical and biophysical research communications.

Isolation and characterization of hybrids between mouse and Chinese hamster cell lines.

H. Koyama, T. Ono, I. Yatabe, 1970, Experimental cell research.

Decreased mutant frequency in embryonic brain of DNA polymerase β null mice

M. Katsuki, Y. Gondo, H. Koyama, 2006 .

Intermediate fragments of newly replicated DNA in mammalian cells. II. Effect of cycloheximide on DNA chain elongation.

H. Koyama, T. Ono, M. Hyodo, 1971, Experimental cell research.

Adenine phosphoribosyltransferase deficiency in cultured mouse mammary tumor FM3A cells resistant to 4-carbamoylimidazolium 5-olate.

H. Koyama, H. Kodama, 1982, Cancer research.

Alteration of growth rate and nutritional requirement of hamster brain cells transformed by adenovirus type 12 during their long-term cultivation.

H. Koyama, I. Yamane, T. Kusano, 1967, The Tohoku journal of experimental medicine.

Thymineless death and genetic events in mammalian cells.

T. Seno, H. Koyama, D. Ayusawa, 1985, Basic life sciences.

Isolation of functional cDNA clones for human thymidylate synthase.

T. Seno, H. Koyama, D. Ayusawa, 1984, The Journal of biological chemistry.

Adenine Phosphoribosyltransferase Deficiency Tumor FM3A Cells Resistant to 4-Carbamoylimidazolium 5-Olate

H. Koyama, H. Kodama, 1982 .

Resistance to methotrexate in thymidylate synthetase-deficient mutants of cultured mouse mammary tumor FM3A cells.

T. Seno, H. Koyama, D. Ayusawa, 1981, Cancer research.

Thymidylate stress induces homologous recombination activity in mammalian cells.

T. Seno, H. Koyama, D. Ayusawa, 1991, Mutation research.

Chromosome breakage induced by thymidylate stress in thymidylate synthase-negative mutants of mouse FM3A cells.

T. Seno, H. Koyama, D. Ayusawa, 1984, Cancer research.

Unusual aspects of human thymidylate synthase in mouse cells introduced by DNA-mediated gene transfer.

T. Seno, H. Koyama, D. Ayusawa, 1983, The Journal of biological chemistry.

Conditional thymidine auxotrophic mutants of mouse FM3A cells due to thermosensitive thymidylate synthase and their prototrophic revertants.

T. Seno, H. Koyama, D. Ayusawa, 1981, The Journal of biological chemistry.

Assignment of human gene encoding thymidylate synthase to chromosome 18 using interspecific cell hybrids between thymidylate synthase-Negative mouse mutant cells and human diploid fibroblasts

T. Seno, H. Koyama, D. Ayusawa, 1985, Somatic cell and molecular genetics.

A new system for analyzing LINE retrotransposition in the chicken DT40 cell line widely used for reverse genetics.

N. Okada, H. Koyama, T. Ono, 2007, Gene.

Decreased c‐Myc expression and its involvement in X‐ray‐induced apoptotic cell death of human T‐cell leukaemia cell line MOLT‐4

Y. Hosoi, A. Enomoto, A. Morita, 2003, International journal of radiation biology.

The human pre-B cell line Nalm-6 is highly proficient in gene targeting by homologous recombination.

Kiyoshi Miyagawa, K. Miyagawa, H. Koyama, 2006, DNA and cell biology.

Human Mus81 and FANCB independently contribute to repair of DNA damage during replication

H. Koyama, N. Adachi, Y. Nomura, 2007, Genes to cells : devoted to molecular & cellular mechanisms.

DISTRIBUTION OF TROPOMYOSIN ISOFORMS IN SPINY LOBSTER MUSCLES

H. Koyama, T. Ishimoda-takagi, M. Itoh, 1997 .

53BP1 contributes to survival of cells irradiated with X‐ray during G1 without Ku70 or Artemis

T. Date, Kuniyoshi Iwabuchi, H. Tauchi, 2006, Genes to cells : devoted to molecular & cellular mechanisms.

KU70/80, DNA-PKcs, and Artemis are essential for the rapid induction of apoptosis after massive DSB formation.

H. Koyama, N. Adachi, M. Takata, 2008, Cellular signalling.

DNA polymerase beta is not essential for the formation of palindromic (P) region of T cell receptor gene.

H. Koyama, A. Shimizu, M. Sugai, 2001, Immunology letters.

Mutagenicity of metal cations in cultured cells from Chinese hamster.

M. Miyaki, H. Koyama, T. Ono, 1979, Mutation research.

p53 Deficiency Rescues Neuronal Apoptosis but Not Differentiation in DNA Polymerase β-Deficient Mice

H. Koyama, N. Niimi, Y. Aratani, 2004, Molecular and Cellular Biology.

Genetic Evidence That the Non-Homologous End-Joining Repair Pathway Is Involved in LINE Retrotransposition

N. Okada, H. Koyama, N. Adachi, 2009, PLoS genetics.

NK314, a Topoisomerase II Inhibitor That Specifically Targets the α Isoform*

K. Nishikawa, H. Koyama, N. Adachi, 2008, Journal of Biological Chemistry.

The requirement of Artemis in double-strand break repair depends on the type of DNA damage.

H. Koyama, S. Takayama, M. Fujii, 2008, DNA and cell biology.

Genetic evidence for involvement of two distinct nonhomologous end-joining pathways in repair of topoisomerase II-mediated DNA damage.

H. Koyama, Sairei So, N. Adachi, 2004, Biochemical and biophysical research communications.

Impact of non-homologous end-joining deficiency on random and targeted DNA integration: implications for gene targeting

H. Koyama, Sairei So, N. Adachi, 2008, Nucleic acids research.

Hypersensitivity of Nonhomologous DNA End-joining Mutants to VP-16 and ICRF-193

H. Koyama, N. Adachi, Susumu Iiizumi, 2003, Journal of Biological Chemistry.

Cell-cycle-directed regulation of thymidylate synthase messenger RNA in human diploid fibroblasts stimulated to proliferate.

T. Seno, H. Koyama, D. Ayusawa, 1986, Journal of molecular biology.

Parp‐1 protects homologous recombination from interference by Ku and Ligase IV in vertebrate cells

V. Schreiber, M. Masutani, G. de Murcia, 2006, The EMBO journal.

Site-specific integration of adeno-associated virus-based plasmid vectors in lipofected HeLa cells.

H. Koyama, N. Sakuragawa, H. Tsunoda, 2000, Virology.

Analysis of polarity of bovine and rabbit embryos by scanning electron microscopy.

H. Koyama, R. Foote, X. Yang, 1994, Biology of reproduction.

Generation of tetracycline-inducible conditional gene knockout cells in a human Nalm-6 cell line.

H. Koyama, T. Ono, N. Adachi, 2009, Journal of biotechnology.

Involvement of SAPK/JNK pathway in X-ray-induced rapid cell death of human T-cell leukemia cell line MOLT-4.

A. Enomoto, A. Morita, H. Koyama, 2000, Cancer letters.

A new cell line derived from newborn Chinese hamster lung tissue.

H. Koyama, T. Ono, T. Utakoji, 1970, Gan.

Fen-1 Facilitates Homologous Recombination by Removing Divergent Sequences at DNA Break Ends

Y. Taniguchi, M. Jasin, H. Koyama, 2005, Molecular and Cellular Biology.

Cellular distribution of mammalian DNA topoisomerase II is determined by its catalytically dispensable C-terminal domain.

S. Kato, R. Kanamaru, H. Koyama, 1997, Nucleic Acids Research.

Development of thermotolerance requires interaction between polymerase‐β and heat shock proteins

A. Takahashi, T. Ohnishi, K. Ohnishi, 2008, Cancer science.

Intermediate fragments of the newly replicated DNA in mammalian cells.

H. Koyama, T. Ono, M. Hyodo, 1970, Biochemical and biophysical research communications.

Adipose conversion of mouse bone marrow fibroblasts in vitro: their alkaline phosphatase activity.

H. Koyama, H. Sudo, S. Kasai, 1983, Cell structure and function.

Effects of adenosine 3':5'-cyclic monophosphate and serum on synthesis of hyaluronic acid in confluent rat fibroblasts.

H. Koyama, M. Tomida, T. Ono, 1977, The Biochemical journal.

Decreased mutant frequency in embryonic brain of DNA polymerase beta null mice.

M. Katsuki, Y. Gondo, H. Koyama, 2006, Mutagenesis.

Isolation of human purH gene expressed in the rodent transformant cells by subtractive enrichment of 3'-untranslated region of human transcript.

K. Mita, N. Seki, H. Koyama, 1995, DNA research : an international journal for rapid publication of reports on genes and genomes.

Relative contributions of myeloperoxidase and NADPH-oxidase to the early host defense against pulmonary infections with Candida albicans and Aspergillus fumigatus.

Haruo Watanabe, M. Dinauer, H. Koyama, 2002, Medical mycology.