P. J. Brooks

发表

The Platform Vector Gene Therapies Project: Increasing the Efficiency of Adeno-Associated Virus Gene Therapy Clinical Trial Startup

C. Austin, C. Bönnemann, P. J. Brooks, 2020, Human gene therapy.

The NIH Extracellular RNA Communication Consortium

John S. Satterlee, J. Satterlee, D. Tagle, 2015, Journal of extracellular vesicles.

The Alcohol Flushing Response: An Unrecognized Risk Factor for Esophageal Cancer from Alcohol Consumption

David Goldman, Ting-kai Li, D. Goldman, 2009, PLoS medicine.

Alcohol consumption and ethyl carbamate.

V. Beral, W. Willett, K. Straif, 2010, IARC monographs on the evaluation of carcinogenic risks to humans.

DNA repair in human fibroblasts, as reflected by host-cell reactivation of a transfected UV-irradiated luciferase gene, is not related to donor age.

R. Tarone, P. J. Brooks, T. Merkle, 2004, Mutation research.

Dysregulation of gene expression as a cause of Cockayne syndrome neurological disease

A. Stewart, P. Chakravarty, G. Schiavo, 2014, Proceedings of the National Academy of Sciences.

Prolactin receptor messenger RNA is synthesized by the epithelial cells of the choroid plexus.

D. Pfaff, C. Mobbs, P. J. Brooks, 1992, Brain research. Molecular brain research.

Stimulation of expression of the oxytocin gene in rat supraoptic neurons at parturition

H. Meeren, D. Pfaff, P. J. Brooks, 1998, Brain Research.

Preproenkephalin mRNA is Regulated by an Interaction Between Steroid Hormones and Nociceptive Stimulation

D. Pfaff, P. J. Brooks, D. Holtzman, 1997, Journal of neuroendocrinology.

Neuropeptide Control of Parental and Reproductive Behavior

P. J. Brooks, C. Pedersen, J. D. Caldwell, 1990 .

Alcohol Metabolism and Its Implications for Cancer

P. J. Brooks, G. Murray, S. Zakhari, 2011 .

Differential Blocking Effects of the Acetaldehyde-derived DNA Lesion N2-Ethyl-2′-deoxyguanosine on Transcription by Multisubunit and Single Subunit RNA Polymerases*

A. Gnatt, P. J. Brooks, Xiaopeng Hu, 2008, Journal of Biological Chemistry.

Blood Leukocyte Counts and Genetic Polymorphisms of Alcohol Dehydrogenase-1B and Aldehyde Dehydrogenase-2 in Japanese Alcoholic Men.

S. Higuchi, P. J. Brooks, T. Matsui, 2016, Alcoholism, clinical and experimental research.

Changes in estrogenic regulation of estrogen receptor α mRNA and progesterone receptor mRNA in the female rat hypothalamus during aging: an in situ hybridization study

D. Pfaff, C. Mobbs, P. J. Brooks, 2000, Neuroscience Research.

Changes in preproenkephalin messenger RNA level in the rat ventromedial hypothalamus during the estrous cycle.

D. Pfaff, C. Mobbs, P. J. Brooks, 1995, Brain research. Molecular brain research.

Growth hormone dependence of somatomedin-C/insulin-like growth factor-I and insulin-like growth factor-II messenger ribonucleic acids.

P. J. Brooks, J. V. Van Wyk, A. D'ercole, 1987, Molecular endocrinology.

The Cost-Effectiveness of Clinical Sequencing

P. J. Brooks, D. Veenstra, 2015 .

The oxidatively induced DNA lesions 8,5′-cyclo-2′-deoxyadenosine and 8-hydroxy-2′-deoxyadenosine are strongly resistant to acid-induced hydrolysis of the glycosidic bond

P. J. Brooks, M. Dizdaroglu, P. Jaruga, 2007, Mechanisms of Ageing and Development.

Gene therapy for rare diseases: summary of a National Institutes of Health workshop, September 13, 2012.

B. Byrne, S. Jacobson, K. Cornetta, 2013, Human gene therapy.

The past, present, and future of modeling Cockayne Syndrome - A commentary on "Rat Model of Cockayne Syndrome Neurological Disease".

P. J. Brooks, C. A. Pacak, 2020, DNA repair.

The Regulation of Oxytocin mRNA Levels in the Medial Preoptic Area

P. J. Brooks, 1992, Annals of the New York Academy of Sciences.

DNA Methylation and DNase-Hypersensitive Sites in the 5′ Flanking and Transcribed Regions of the Rat Preproenkephalin Gene: Studies of Mediobasal Hypothalamus

D. Pfaff, C. Mobbs, P. J. Brooks, 1993, Molecular and Cellular Neuroscience.

Therapies for rare diseases: therapeutic modalities, progress and challenges ahead

Tudor I. Oprea, Christopher P. Austin, Marco Prunotto, 2019, Nature Reviews Drug Discovery.

The Oxidative DNA Lesion 8,5′-(S)-Cyclo-2′-deoxyadenosine Is Repaired by the Nucleotide Excision Repair Pathway and Blocks Gene Expression in Mammalian Cells*

R. Tarone, M. Smerdon, P. J. Brooks, 2000, The Journal of Biological Chemistry.

Mechanism of RNA polymerase II bypass of oxidative cyclopurine DNA lesions

A. Gnatt, Dong Wang, M. Kashlev, 2015, Proceedings of the National Academy of Sciences.

Transcriptional bypass of bulky DNA lesions causes new mutant RNA transcripts in human cells

P. J. Brooks, C. Marietta, 2007, EMBO reports.

Endogenous formation and repair of oxidatively induced G[8-5 m]T intrastrand cross-link lesion

P. J. Brooks, Yinsheng Wang, C. Nishigori, 2012, Nucleic acids research.

ATM, the Mre11/Rad50/Nbs1 complex, and topoisomerase I are concentrated in the nucleus of Purkinje neurons in the juvenile human brain.

P. J. Brooks, E. Gorodetsky, Sarah Calkins, 2007, DNA repair.

Oxytocin Messenger Ribonucleic Acid Levels in the Medial Preoptic Area are Increased During Lactation

P. J. Brooks, C. Pedersen, W. Stumpf, 1990, Journal of neuroendocrinology.

The 8,5'-cyclopurine-2'-deoxynucleosides: candidate neurodegenerative DNA lesions in xeroderma pigmentosum, and unique probes of transcription and nucleotide excision repair.

P. J. Brooks, Philip J. Brooks, 2008, DNA repair.

The cyclopurine deoxynucleosides: DNA repair, biological effects, mechanistic insights, and unanswered questions.

P. J. Brooks, 2017, Free radical biology & medicine.

Novel approaches to the study of oxytocin neurotransmission in the rat brain

D. Pfaff, M. McCarthy, P. J. Brooks, 1993, Regulatory Peptides.

Effects of 5',8-cyclodeoxyadenosine triphosphates on DNA synthesis.

P. J. Brooks, S. Iwai, I. Kuraoka, 2012, Chemical research in toxicology.

Divergent effects of oxidatively induced modification to the C8 of 2′‐deoxyadenosine on transcription factor binding: 8,5′(S)‐cyclo‐2′‐deoxyadenosine inhibits the binding of multiple sequence specific transcription factors, while 8‐oxo‐2′‐deoxyadenosine increases binding of CREB and NF‐kappa B to DN

P. J. Brooks, Jessy Abraham, 2011, Environmental and molecular mutagenesis.

Complete release of (5'S)-8,5'-cyclo-2'-deoxyadenosine from dinucleotides, oligodeoxynucleotides and DNA, and direct comparison of its levels in cellular DNA with other oxidatively induced DNA lesions.

P. J. Brooks, M. Dizdaroglu, P. Jaruga, 2004, Nucleic acids research.

DNA repair in neural cells: basic science and clinical implications.

P. J. Brooks, Philip J. Brooks, 2002, Mutation research.

A single 8,5'-cyclo-2'-deoxyadenosine lesion in a TATA box prevents binding of the TATA binding protein and strongly reduces transcription in vivo.

P. J. Brooks, C. Marietta, Huzaefah Gulam, 2002, DNA repair.

Quantitative and in situ Detection of Oxidatively Generated DNA Damage 8,5′‐Cyclo‐2′‐Deoxyadenosine Using an Immunoassay with a Novel Monoclonal Antibody

P. J. Brooks, Toshio Mori, N. Kobayashi, 2014, Photochemistry and photobiology.

Quantitative assessment of Tet-induced oxidation products of 5-methylcytosine in cellular and tissue DNA

Hongjun Song, D. Fisher, Yijing Su, 2013, Nucleic acids research.

Antisense Oligodeoxynucleotides in Behavioral Neuroscience

D. Pfaff, M. McCarthy, P. J. Brooks, 1993 .

Mutant Cockayne syndrome group B protein inhibits repair of DNA topoisomerase I‐DNA covalent complex

A. Yasui, M. Honma, P. J. Brooks, 2011, Genes to cells : devoted to molecular & cellular mechanisms.

DNA adducts from acetaldehyde: implications for alcohol-related carcinogenesis.

P. J. Brooks, J. Theruvathu, 2005, Alcohol.

Widespread expression and estrogen regulation of PPEIA-3' nuclear RNA in the rat brain.

D. Pfaff, C. Mobbs, P. J. Brooks, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Detection of messenger RNA and low-abundance heteronuclear RNA with single-stranded DNA probes produced by amplified primer extension labeling.

D. Pfaff, M. Kaplitt, C. Mobbs, 1993, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Cell-specific expression of preproenkephalin intronic heteronuclear RNA in the rat forebrain.

D. Pfaff, C. Mobbs, P. J. Brooks, 1993, Brain research. Molecular brain research.

Acetaldehyde and the genome: Beyond nuclear DNA adducts and carcinogenesis

P. J. Brooks, S. Zakhari, 2014, Environmental and molecular mutagenesis.

The NIH Somatic Cell Genome Editing program

David R. Liu, Benjamin S. Freedman, Daniel G. Anderson, 2021, Nature.

82 – DNA Damage Resulting from Alcohol Abuse with Special Reference to the Brain

P. J. Brooks, R. Nath, J. Theruvathu, 2004 .

DNA damage, DNA repair, and alcohol toxicity--a review.

P. J. Brooks, 1997, Alcoholism, clinical and experimental research.

Insulin-like growth factor II messenger ribonucleic acids are synthesized in the choroid plexus of the rat brain.

P. J. Brooks, J. V. Van Wyk, M. Hynes, 1988, Molecular endocrinology.

Moderate alcohol consumption and breast cancer in women: from epidemiology to mechanisms and interventions.

P. J. Brooks, S. Zakhari, 2013, Alcoholism, clinical and experimental research.

Gene Therapy: The View from NCATS

Christopher P. Austin, Philip J. Brooks, C. Austin, 2016, Human gene therapy.

Blinded by the UV light: how the focus on transcription-coupled NER has distracted from understanding the mechanisms of Cockayne syndrome neurologic disease.

P. J. Brooks, 2013, DNA repair.

Overexpression of an epitope-tagged serotonin transporter in serotonin neurons of the dorsal raphe nucleus using a defective HSV-1 vector

P. J. Brooks, B. Hoffman, D. Goldman, 2003, Behavioural Brain Research.

Brain atrophy and neuronal loss in alcoholism: a role for DNA damage?

P. J. Brooks, 2000, Neurochemistry International.

Do all of the neurologic diseases in patients with DNA repair gene mutations result from the accumulation of DNA damage?

P. J. Brooks, Tsu-Fan Cheng, Lori Cooper, 2008, DNA repair.

A 32P-Postlabeling Assay for the Oxidative DNA Lesion 8,5′-Cyclo-2′-deoxyadenosine in Mammalian Tissues

P. J. Brooks, G. Zhou, K. Randerath, 2001, The Journal of Biological Chemistry.

The case for 8,5′-cyclopurine-2′-deoxynucleosides as endogenous DNA lesions that cause neurodegeneration in xeroderma pigmentosum

P. J. Brooks, PJ Brooks, 2007, Neuroscience.

Therapies for rare diseases: therapeutic modalities, progress and challenges ahead

Tudor I. Oprea, T. Oprea, C. Austin, 2019, Nature Reviews Drug Discovery.

Detection of excision nuclease in cell-free extracts from the adult mammalian brain.

P. J. Brooks, 1998, Mutation research.

Gene memory in neuroendocrine and behavioural systems.

D. Pfaff, C. Mobbs, P. J. Brooks, 1992, Ciba Foundation symposium.

Enhancement of camptothecin-induced topoisomerase I cleavage complexes by the acetaldehyde adduct N2-ethyl-2'-deoxyguanosine.

Y. Pommier, M. Redinbo, P. J. Brooks, 2004, Nucleic acids research.

Alleles of alcohol and acetaldehyde metabolism genes modulate susceptibility to oesophageal cancer from alcohol consumption

Ting-kai Li, D. Goldman, P. J. Brooks, 2009, Human Genomics.

Insight into mechanisms of 3′-5′ exonuclease activity and removal of bulky 8,5′-cyclopurine adducts by apurinic/apyrimidinic endonucleases

Abdelghani Mazouzi, S. Moréra, P. J. Brooks, 2013, Proceedings of the National Academy of Sciences.

Luteinizing Hormone‐Releasing Hormone Receptor Messenger Ribonucleic Acid Expression in the Rat Pituitary during Lactation and the Estrous Cycle

D. Pfaff, P. J. Brooks, T. Funabashi, 1994, Journal of neuroendocrinology.

A Quantitative Assay for Assessing the Effects of DNA Lesions on Transcription

P. J. Brooks, Yinsheng Wang, L. Niedernhofer, 2012, Nature chemical biology.

Expression of long-patch and short-patch DNA mismatch repair proteins in the embryonic and adult mammalian brain.

J. Jiricny, P. J. Brooks, F. Palombo, 1998, Brain research. Molecular brain research.

Gene‐targeted therapies: Overview and implications

P. J. Brooks, M. Parisi, T. Urv, 2023, American journal of medical genetics. Part C, Seminars in medical genetics.

Impaired spermatogenesis and elevated spontaneous tumorigenesis in xeroderma pigmentosum group A gene (Xpa)-deficient mice.

S. Hirota, Y. Nakatsu, Y. Nakabeppu, 2008, DNA repair.

Acetaldehyde stimulates FANCD2 monoubiquitination, H2AX phosphorylation, and BRCA1 phosphorylation in human cells in vitro: implications for alcohol-related carcinogenesis.

J. Lamerdin, L. Thompson, P. J. Brooks, 2009, Mutation research.

Implications of acetaldehyde-derived DNA adducts for understanding alcohol-related carcinogenesis.

P. J. Brooks, S. Balbo, 2015, Advances in experimental medicine and biology.

Polyamines stimulate the formation of mutagenic 1,N2-propanodeoxyguanosine adducts from acetaldehyde

P. J. Brooks, M. Dizdaroglu, P. Jaruga, 2005, Nucleic acids research.

Recovery from anemia and leukocytopenia after abstinence in Japanese alcoholic men and their genetic polymorphisms of alcohol dehydrogenase-1B and aldehyde dehydrogenase-2

P. J. Brooks, A. Yokoyama, T. Yokoyama, 2017, Japanese journal of clinical oncology.

Macrocytosis, macrocytic anemia, and genetic polymorphisms of alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 in Japanese alcoholic men.

S. Higuchi, P. J. Brooks, T. Matsui, 2014, Alcoholism, clinical and experimental research.

Local Morphine Withdrawal Increases c-fos Gene, Fos Protein, and Oxytocin Gene Expression in Hypothalamic Magnocellular Neurosecretory Cells

H. Meeren, P. J. Brooks, L. E. Johnstone, 2000, The Journal of Neuroscience.

Moving away from one disease at a time: Screening, trial design, and regulatory implications of novel platform technologies

T. Yu, P. J. Brooks, D. Koeberl, 2023, American journal of medical genetics. Part C, Seminars in medical genetics.

Effect of lesion location within the medial preoptic-anterior hypothalamic continuum on maternal and male sexual behaviors in female rats.

P. J. Brooks, P. Gray, 1984, Behavioral neuroscience.

Alcohol as a Human Carcinogen

P. J. Brooks, 2011 .

Future Directions in Alcoholism Research

P. J. Brooks, Robert Lipsky, 2000, Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism.

Fu t u re Di rections in Alcoholism Re s e a rc h Genomics and Gene Transfer

P. J. Brooks, Robert Lipsky, 2000 .

Localization and regulation of IGF-I and IGF-II mRNA

P. J. Brooks, J. English, M. Hynes, 1989 .

Return of Anticipated and Incidental Results from Next-Generation Sequencing: Implications for Providers and Patients

Janet K. Williams, P. J. Brooks, A. Cashion, 2015 .

Timeless insights into prevention of acetaldehyde genotoxicity?

K. Schuebel, P. J. Brooks, 2017, Cell cycle.

DNA damage, repair, and antioxidant systems in brain regions: a correlative study.

P. J. Brooks, F. Cardozo-Pelaez, T. Stedeford, 2000, Free radical biology & medicine.

Expanding rare disease drug trials based on shared molecular etiology

D. Tagle, P. J. Brooks, S. Groft, 2014, Nature Biotechnology.

Targeting shared molecular etiologies to accelerate drug development for rare diseases

P. J. Brooks, R. Nabbout, Chun‐Hung Chan, 2023, EMBO molecular medicine.

Publisher Correction: Therapies for rare diseases: therapeutic modalities, progress and challenges ahead

Tudor I. Oprea, C. Austin, M. Prunotto, 2020, Nature Reviews Drug Discovery.