E. Ottinger

发表

The Platform Vector Gene Therapies Project: Increasing the Efficiency of Adeno-Associated Virus Gene Therapy Clinical Trial Startup

C. Austin, C. Bönnemann, P. J. Brooks, 2020, Human gene therapy.

Fostering collaborative research for rare genetic disease: the example of niemann-pick type C disease

C. Vite, C. Austin, D. Ory, 2016, Orphanet Journal of Rare Diseases.

A validated LC-MS/MS assay for quantification of 24(S)-hydroxycholesterol in plasma and cerebrospinal fluid[S]

D. Ory, J. Schaffer, E. Ottinger, 2015, Journal of Lipid Research.

A novel cell immunoassay to measure survival of motor neurons protein in blood cells

K. Fischbeck, G. Dreyfuss, A. Gubitz, 2006, BMC neurology.

Neural stem cells for disease modeling and evaluation of therapeutics for infantile (CLN1/PPT1) and late infantile (CLN2/TPP1) neuronal ceroid lipofuscinoses

Wei Zheng, J. Marugan, E. Ottinger, 2018, Orphanet Journal of Rare Diseases.

In vitro and in vivo translational models for rare liver diseases.

M. Ferrer, E. Ottinger, S. Haugabook, 2019, Biochimica et biophysica acta. Molecular basis of disease.

Phosphocyclocreatine is the dominant form of cyclocreatine in control and creatine transporter deficiency patient fibroblasts

A. Wang, Wei Zheng, N. Longo, 2019, Pharmacology research & perspectives.

In vitro association of the phosphatidylinositol 3-kinase regulatory subunit (p85) with the human insulin receptor.

D. Bernlohr, E. Ottinger, Z. Man, 2009, International journal of peptide and protein research.

Cellular effects of phosphotyrosine-binding domain inhibitors on insulin receptor signaling and trafficking

S. Shoelson, E. Ottinger, T. Burke, 1997, Molecular and cellular biology.

Specific redistribution of cell-penetrating peptides from endosomes to the cytoplasm and nucleus upon laser illumination.

M. Ferrer, E. Ottinger, J. Maiolo, 2004, Journal of the American Chemical Society.

Cholesterol homeostatic responses provide biomarkers for monitoring treatment for the neurodegenerative disease Niemann-Pick C1 (NPC1).

C. Vite, J. Heiss, D. Ory, 2014, Human molecular genetics.

Immunogenicity in mice and non-human primates of the Group A Streptococcal J8 peptide vaccine candidate conjugated to CRM197

E. Ottinger, J. Heinrichs, M. Batzloff, 2013, Human vaccines & immunotherapeutics.

Collaborative development of 2-hydroxypropyl-β-cyclodextrin for the treatment of Niemann-Pick type C1 disease.

W. Pavan, C. Vite, C. Austin, 2014, Current topics in medicinal chemistry.

Development and validation of sensitive LC-MS/MS assays for quantification of HP-β-CD in human plasma and CSF

D. Ory, E. Ottinger, F. Porter, 2014, Journal of Lipid Research.

Detection and minimization of H-phosphonate side reaction during phosphopeptide synthesis by a post-assembly global phosphorylation strategy

E. Ottinger, N. Solé, G. Bárány, 2004, Letters in Peptide Science.

In Vivo Efficacy of VT-1129 against Experimental Cryptococcal Meningitis with the Use of a Loading Dose-Maintenance Dose Administration Strategy

A. Wang, E. Garvey, E. Ottinger, 2018, Antimicrobial Agents and Chemotherapy.

The Fungal Cyp51 Inhibitor VT-1129 Is Efficacious in an Experimental Model of Cryptococcal Meningitis

E. Garvey, E. Ottinger, A. Alimardanov, 2018, Antimicrobial Agents and Chemotherapy.

The Investigational Fungal Cyp51 Inhibitor VT-1129 Demonstrates Potent In Vitro Activity against Cryptococcus neoformans and Cryptococcus gattii

E. Garvey, E. Ottinger, S. Lockhart, 2016, Antimicrobial Agents and Chemotherapy.

Tandem SH2 Domains Confer High Specificity in Tyrosine Kinase Signaling*

S. Shoelson, E. Ottinger, M. Botfield, 1998, The Journal of Biological Chemistry.

PTB Domains of IRS-1 and Shc Have Distinct but Overlapping Binding Specificities (*)

M. White, S. Shoelson, E. Ottinger, 1995, The Journal of Biological Chemistry.

Crystal structure of the pleckstrin homology-phosphotyrosine binding (PH-PTB) targeting region of insulin receptor substrate 1.

S. Shoelson, M. Eck, E. Ottinger, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Synthesis of phosphotyrosine-containing peptides and their use as substrates for protein tyrosine phosphatases.

D. Bernlohr, E. Ottinger, G. Bárány, 1993, Biochemistry.

Modular Folding and Evidence for Phosphorylation-induced Stabilization of an hsp90-dependent Kinase*

E. Ottinger, R. Matts, P. Burn, 1998, The Journal of Biological Chemistry.

Inactivation of the SMN complex by oxidative stress.

G. Dreyfuss, E. Ottinger, Sungchan Cho, 2008, Molecular cell.

Specificity of the PTB Domain of Shc for β Turn-forming Pentapeptide Motifs Amino-terminal to Phosphotyrosine (*)

S. Shoelson, E. Ottinger, W. Choi, 1995, The Journal of Biological Chemistry.

Small Molecule Mimetics of an HIV-1 gp41 Fusion Intermediate as Vaccine Leads

G. McGaughey, E. Ottinger, M. Citron, 2010, The Journal of Biological Chemistry.

Sporozoite neutralizing antibodies elicited in mice and rhesus macaques immunized with a Plasmodium falciparum repeat peptide conjugated to meningococcal outer membrane protein complex

J. Shiver, D. Kaslow, E. Ottinger, 2012, Front. Cell. Inf. Microbio..

Engineering, Generation and Preliminary Characterization of a Humanized Porcine Sickle Cell Disease Animal Model

E. Ottinger, T. Townes, C. Rogers, 2020, bioRxiv.

Intrathecal 2-hydroxypropyl-β-cyclodextrin decreases neurological disease progression in Niemann-Pick disease, type C1: a non-randomised, open-label, phase 1–2 trial

Kimberly A. Walters, W. Pavan, C. Vite, 2017, The Lancet.

Human GRB-IRbeta/GRB10. Splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains.

S. Shoelson, E. Ottinger, S. Giorgetti-Peraldi, 1997, The Journal of biological chemistry.

Vaccination with peptide mimetics of the gp41 prehairpin fusion intermediate yields neutralizing antisera against HIV-1 isolates

D. Montefiori, J. Shiver, A. Finnefrock, 2010, Proceedings of the National Academy of Sciences.

Human GRB-IRβ/GRB10

S. Shoelson, E. Ottinger, S. Giorgetti-Peraldi, 1997, The Journal of Biological Chemistry.

Disease models for the development of therapies for lysosomal storage diseases

M. Ferrer, Wei Zheng, J. Marugan, 2016, Annals of the New York Academy of Sciences.

Effects of cargo molecules on the cellular uptake of arginine-rich cell-penetrating peptides.

M. Ferrer, E. Ottinger, J. Maiolo, 2005, Biochimica et biophysica acta.

Design and synthesis of inhibitors of the protein tyrosine phosphatase, SHP-2

E. Ottinger, Erin E. Wimmers, Jim L. Lehnhoff, 2002 .

Phase 1/2 evaluation of intrathecal 2-hydroxypropyl-β-cyclodextrin for the treatment of Niemann-Pick disease type C1

C. Vite, L. Weissfeld, D. Ory, 2016 .

Rare disease variant curation from literature: assessing gaps with creatine transport deficiency in focus

Mohammad S. Alodadi, U. Mudunuri, E. Ottinger, 2023, BMC Genomics.