J. Rak

S. Daniel, J. Rak, B. Meehan, 2014, Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology.

Elevated tissue factor procoagulant activity in CD133‐positive cancer cells

J. Rak, J. Weitz, G. Anderson, 2007, Journal of Thrombosis and Haemostasis.

Illustrated State‐of‐the‐Art Capsules of the ISTH 2019 Congress in Melbourne, Australia

C. Maas, L. Rauova, J. Eikelboom, 2019, Research and practice in thrombosis and haemostasis.

The benefit‐to‐risk profile of melagatran is superior to that of hirudin in a rabbit arterial thrombosis prevention and bleeding model

J. Rak, M. Johnston, P. Klement, 2003, Journal of thrombosis and haemostasis : JTH.

Oncogenic RAS drives the CRAF‐dependent extracellular vesicle uptake mechanism coupled with metastasis

L. Montermini, D. Choi, J. Rak, 2021, Journal of extracellular vesicles.

Differential influence of organ site on three subpopulations of a single mouse mammary tumor at two distinct steps in metastasis

J. Rak, F. Miller, B. Miller, 1991, International journal of cancer.

A role for survivin in chemoresistance of endothelial cells mediated by VEGF

R. Kerbel, J. Rak, D. Dumont, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Selection of Fluorescent, Bioluminescent, and Radioactive Tracers to Accurately Reflect Extracellular Vesicle Biodistribution in Vivo

J. Rak, K. Al‐Jamal, N. Dekker, 2021, ACS nano.

Induction and reversal of cell adhesion-dependent multicellular drug resistance in solid breast tumors.

R. Kerbel, V. A. Flørenes, J. Rak, 1996, Human cell.

Genetic determinants of cancer coagulopathy, angiogenesis and disease progression.

J. Rak, P. Klement, J. Yu, 2006, Vnitrni lekarstvi.

Is there a role for anti-adhesives as chemosensitizers in the treatment of solid tumours by chemotherapy ? : Metastases

R. Kerbel, J. Rak, B. S. Croix, 1994 .

Cancer genetic alterations and risk of venous thromboembolism.

J. Rak, S. Mantha, 2022, Thrombosis research.

Detection of temozolomide-induced hypermutation and response to PD-1 checkpoint inhibitor in recurrent glioblastoma

J. Sarkaria, D. Choi, J. Rak, 2022, Neuro-oncology advances.

Antibody-based targeting of alternatively spliced tissue factor: a new approach to impede the primary growth and spread of pancreatic ductal adenocarcinoma

J. Rak, N. Mackman, H. Versteeg, 2016, Oncotarget.

Impact of the cyclin–dependent kinase inhibitor p27Kip1 on resistance of tumor cells to anticancer agents

R. Kerbel, V. A. Flørenes, J. Slingerland, 1996, Nature Medicine.

Antithrombin-Heparin Covalent Complex: A Possible Alternative to Heparin for Arterial Thrombosis Prevention

J. Rak, Anthony K. C. Chan, L. Berry, 2002, Circulation.

Oncogenes and Angiogenesis: down-regulation of thrombospondin-1 in normal fibroblasts exposed to factors from cancer cells harboring mutant ras.

R. Benezra, P. Bornstein, J. Rak, 2005, Cancer research.

Mek activity is required for ErbB2 expression in breast cancer cells detached from the extracellular matrix

J. Rak, B. Yoo, K. Rosen, 2017, Oncotarget.

Short Communication Neutralizing Antibodies against Epidermal Growth Factor and ErbB-2lneu Receptor Tyrosine Kinases Down-Regulate Vascular Endothelial Growth Factor Production by Tumor Cells in Vitro and in Vivo Angiogenic Implications for Signal Transduction Solid Tumors Therapy of

N. Goldstein, M. Hung, R. Kerbel, 2007 .

Normoxic and hypoxic regulation of vascular endothelial growth factor (VEGF) by astrocytoma cells is mediated by Ras

R. Kerbel, A. Guha, J. Rak, 1999, International journal of cancer.

Shedding of tissue factor (TF)‐containing microparticles rather than alternatively spliced TF is the main source of TF activity released from human cancer cells

J. Rak, J. Yu, J. Rak, 2004, Journal of thrombosis and haemostasis : JTH.

Massive programmed cell death in intestinal epithelial cells induced by three-dimensional growth conditions: suppression by mutant c-H-ras oncogene expression

R. Kerbel, J. Rak, J. Filmus, 1995, The Journal of cell biology.

Tissue factor in cancer and angiogenesis: the molecular link between genetic tumor progression, tumor neovascularization, and cancer coagulopathy.

J. Rak, Joanne Yu, P. Klement, 2006, Seminars in thrombosis and hemostasis.

New checkpoint of the coagulant phenotype.

J. Rak, 2014, Blood.

The interplay between epigenetic silencing, oncogenic KRas and HIF-1 regulatory pathways in control of BNIP3 expression in human colorectal cancer cells.

J. Rak, W. Kałas, E. Wysokińska, 2013, Biochemical and biophysical research communications.

Contribution of the hemostatic system to angiogenesis in cancer.

J. Rak, M. Wojtukiewicz, E. Sierko, 2004, Seminars in thrombosis and hemostasis.

Vascular endothelial growth factor-dependent spatiotemporal dual roles of placental growth factor in modulation of angiogenesis and tumor growth

Yihai Cao, J. Rak, Sharon Lim, 2013, Proceedings of the National Academy of Sciences.

The 92-kDa gelatinase B is expressed by advanced stage melanoma cells: suppression by somatic cell hybridization with early stage melanoma cells.

R. Kerbel, Y. Lin, J. Rak, 1995, Cancer research.

Angiocrine extracellular vesicles impose mesenchymal reprogramming upon proneural glioma stem cells

I. Nakano, J. Rak, B. Meehan, 2022, Nature Communications.

Leukocytes as a reservoir of circulating oncogenic DNA and regulatory targets of tumor‐derived extracellular vesicles

L. Montermini, D. Choi, J. Rak, 2018, Journal of thrombosis and haemostasis : JTH.

Host microenvironment in breast cancer development: Inflammatory and immune cells in tumour angiogenesis and arteriogenesis

J. Rak, Joanne Yu, 2003, Breast Cancer Research.

Downregulation of the pro-apoptotic protein Bak is required for the ras-induced transformation of intestinal epithelial cells

M. J. Newman, R. Kerbel, J. Rak, 1998, Current Biology.

Sequential alteration of peanut agglutinin binding-glycoprotein expression during progression of murine mammary neoplasia.

D. McEachern, J. Rak, F. Miller, 1992, British Journal of Cancer.

Schmits, R. et al. CD44 regulates hematopoietic progenitor distribution, granuloma formation, and tumorigenicity. Blood 90, 2217-2233

T. Mak, A. Wakeham, J. C. Ramos, 1997 .

An electrochemical clamp assay for direct, rapid analysis of circulating nucleic acids in serum.

Shana O Kelley, Edward H Sargent, Jagotamoy Das, 2015, Nature chemistry.

Oncosomes – large and small: what are they, where they came from?

D. Di Vizio, J. Rak, B. Meehan, 2016, Journal of extracellular vesicles.

von Hippel-Lindau gene-mediated growth suppression and induction of differentiation in renal cell carcinoma cells grown as multicellular tumor spheroids.

W. Kaelin, R. Kerbel, J. Rak, 1998, Cancer research.

Heparin compromises streptokinase-induced arterial patency in rabbits.

J. Rak, J. Gumulec, J. Weitz, 2005, Thrombosis research.

Mesenchymal stem cell-derived small extracellular vesicles mitigate oxidative stress-induced senescence in endothelial cells via regulation of miR-146a/Src

J. Rak, R. Zhao, Shihua Wang, 2021, Signal Transduction and Targeted Therapy.

Role of extracellular vesicles in cancer-specific interactions between tumour cells and the vasculature.

J. Rak, L. Adnani, N. Tawil, 2022, Seminars in cancer biology.

Quantitative proteomics and biological activity of extracellular vesicles engineered to express SARS‐CoV‐2 spike protein

Dae-Kyum Kim, L. Montermini, D. Choi, 2022, Journal of extracellular biology.

Increased resistance to oncostatin M-induced growth inhibition of human melanoma cell lines derived from advanced-stage lesions.

R. Kerbel, J. Rak, H. Kobayashi, 1993, Cancer research.

E-Cadherin–dependent Growth Suppression is Mediated by the Cyclin-dependent Kinase Inhibitor p27KIP1

Robert S. Kerbel, R. Kerbel, V. A. Flørenes, 1998, The Journal of cell biology.

Application of Peano Kernel

J. Rak, 2010 .

The hemostatic system and angiogenesis in malignancy.

J. Rak, M. Wojtukiewicz, E. Sierko, 2001, Neoplasia.

SMARCA4/2 loss inhibits chemotherapy-induced apoptosis by restricting IP3R3-mediated Ca2+ flux to mitochondria

W. Foulkes, Sidong Huang, W. Lockwood, 2021, Nature Communications.

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

Jing Xu, Antonella Bongiovanni, Wilfrid Boireau, 2018, Journal of Extracellular Vesicles.

Inactive-to-Active Transition of Human Thymidine Kinase 1 Revealed by Molecular Dynamics Simulations

Z. Cournia, J. Rak, S. Makurat, 2021, J. Chem. Inf. Model..

The Impact of Oncogenic EGFRvIII on the Proteome of Extracellular Vesicles Released from Glioblastoma Cells*

Dae-Kyum Kim, L. Montermini, D. Choi, 2018, Molecular & Cellular Proteomics.

Comparative transcriptomic analysis of human and Drosophila extracellular vesicles

E. Lécuyer, J. Rak, A. Blanchet-Cohen, 2016, Scientific Reports.

Studies on the Tumor Vasculature and Coagulant Microenvironment.

J. Rak, B. Meehan, E. D’Asti, 2016, Methods in molecular biology.

Oncogenes and Clotting Factors: The Emerging Role of Tumor Cell Genome and Epigenome in Cancer-Associated Thrombosis

J. Rak, N. Tawil, Rayhaan Bassawon, 2019, Seminars in Thrombosis and Hemostasis.

Oncogenic extracellular vesicles in brain tumor progression

L. Montermini, J. Rak, Delphine Garnier, 2012, Front. Physio..

Oncogenes and tumor angiogenesis: the HPV-16 E6 oncoprotein activates the vascular endothelial growth factor (VEGF) gene promoter in a p53 independent manner

D. Mukhopadhyay, R. Kerbel, J. Rak, 2000, Oncogene.

Cell surface glycosylation changes accompanying immortalization and transformation of normal human mammary epithelial cells.

J. Russo, F. Basolo, J. Rak, 1991, Cancer letters.

Angiogenesis and Lymphangiogenesis in Colon Cancer Metastasis

J. Rak, Delphine Garnier, 2010 .

Growth advantage (“clonal dominance”) of metastatically competent tumor cell variants expressed under selective two- or three-dimensional tissue culture conditions

R. Kerbel, J. Rak, 1993, In Vitro Cellular & Developmental Biology - Animal.

Oncogenes and Tumor Angiogenesis

R. Kerbel, J. Rak, 2004 .

Vascular endothelial growth factor isoform expression as a determinant of blood vessel patterning in human melanoma xenografts.

R. Kerbel, J. Rak, G. Klement, 2002, Cancer research.

Xenografts Determinant of Blood Vessel Patterning in Human Melanoma Vascular Endothelial Growth Factor Isoform Expression as a Updated

R. Kerbel, J. Rak, G. Klement, 2002 .

Vascular endothelial growth factor isoform expression as a determinant of blood vessel patterning in human melanoma xenografts.

R. Kerbel, J. Rak, G. Klement, 2002, Cancer research.

H‐Ras increases release of sphingosine resulting in down‐regulation of TSP‐1 in non‐transformed cells

A. Gamian, J. Rak, J. Rybka, 2012, International journal of experimental pathology.

Glioblastoma cell populations with distinct oncogenic programs release podoplanin as procoagulant extracellular vesicles.

H. Najafabadi, I. Tirosh, Anoop P. Patel, 2021, Blood advances.

Extracellular Vesicle Proteomes Shed Light on the Evolutionary, Interactive, and Functional Divergence of Their Biogenesis Mechanisms

J. Twizere, Dae-Kyum Kim, J. Rak, 2021, Frontiers in Cell and Developmental Biology.

Molecular subtypes and differentiation programmes of glioma stem cells as determinants of extracellular vesicle profiles and endothelial cell-stimulating activities

L. Montermini, I. Nakano, D. Choi, 2018, Journal of extracellular vesicles.

Single cell coagulomes as constituents of the oncogene-driven coagulant phenotype in brain tumours.

J. Rak, Radia M. Johnson, E. D’Asti, 2018, Thrombosis research.

Divergent evolution of temozolomide resistance in glioblastoma stem cells is reflected in extracellular vesicles and coupled with radiosensitization

T. Kislinger, I. Nakano, J. Rak, 2018, Neuro-oncology.

Extracellular vesicles in the biology of brain tumour stem cells--Implications for inter-cellular communication, therapy and biomarker development.

I. Nakano, J. Rak, Delphine Garnier, 2015, Seminars in cell & developmental biology.

Brain Neoplasms and Coagulation—Lessons from Heterogeneity

J. Rak, Yi Fang, E. D’Asti, 2014, Rambam Maimonides medical journal.

Brain Neoplasms and Coagulation

J. Rak, Delphine Garnier, B. Meehan, 2013, Seminars in Thrombosis & Hemostasis.

Extracellular vesicles as prospective carriers of oncogenic protein signatures in adult and paediatric brain tumours

J. Rak, N. Jabado, Delphine Garnier, 2013, Proteomics.

Extracellular Vesicles – Biomarkers and Effectors of the Cellular Interactome in Cancer

J. Rak, Janusz Rak, 2013, Front. Pharmacol..

Genetic pathways linking hemostasis and cancer.

M. Hashemi, J. Rak, Delphine Garnier, 2012, Thrombosis research.

J. Rak, N. Jabado, N. Magnus, 2013, Journal of thrombosis and haemostasis : JTH.

Impact of host ageing on the metastatic phenotype

L. Montermini, J. Rak, B. Meehan, 2013, Mechanisms of Ageing and Development.

Endothelial cells promote the colorectal cancer stem cell phenotype through a soluble form of Jagged-1.

L. Ellis, F. Fan, Sendurai A Mani, 2013, Cancer cell.

Cancer Cells Induced to Express Mesenchymal Phenotype Release Exosome-like Extracellular Vesicles Carrying Tissue Factor*

T. Kislinger, L. Montermini, J. Rak, 2012, The Journal of Biological Chemistry.

Tumor-derived tissue factor activates coagulation and enhances thrombosis in a mouse xenograft model of human pancreatic cancer.

J. Yeh, J. Rak, D. Kirchhofer, 2012, Blood.

Microparticles in cancer.

J. Rak, 2010, Seminars in thrombosis and hemostasis.

Oncogenic epidermal growth factor receptor up-regulates multiple elements of the tissue factor signaling pathway in human glioma cells.

J. Rak, Delphine Garnier, N. Magnus, 2010, Blood.

RAS Oncogenes and Tumor-Vascular Interface

J. Rak, 2010 .

Tissue factor and cancer stem cells: is there a linkage?

J. Rak, Delphine Garnier, B. Meehan, 2009, Arteriosclerosis, thrombosis, and vascular biology.

Tissue factor regulation by epidermal growth factor receptor and epithelial-to-mesenchymal transitions: effect on tumor initiation and angiogenesis.

A. Guha, J. Rak, N. Mackman, 2008, Cancer research.

Contribution of Host-Derived Tissue Factor to Tumor Neovascularization

J. Rak, J. Luyendyk, N. Mackman, 2008, Arteriosclerosis, thrombosis, and vascular biology.

Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells

A. Guha, J. Rak, B. Meehan, 2008, Nature Cell Biology.

The role of tumor-and host-related tissue factor pools in oncogene-driven tumor progression.

J. Rak, J. Luyendyk, N. Mackman, 2007, Thrombosis research.

Oncogenes, trousseau syndrome, and cancer-related changes in the coagulome of mice and humans.

J. Rak, J. Luyendyk, N. Mackman, 2006, Cancer research.

Oncogenic events regulate tissue factor expression in colorectal cancer cells: implications for tumor progression and angiogenesis.

S. Shirasawa, J. Rak, N. Mackman, 2005, Blood.

Oncogenes as regulators of tissue factor expression in cancer: implications for tumor angiogenesis and anti-cancer therapy.

J. Rak, J. Weitz, Joanne Yu, 2004, Seminars in thrombosis and hemostasis.

Progressive loss of sensitivity to endothelium‐derived growth inhibitors expressed by human melanoma cells during disease progression

R. Kerbel, J. Rak, Chao Lu, 1994, Journal of cellular physiology.

Mechanisms and Antitumor Activity of a Binary EGFR/DNA–Targeting Strategy Overcomes Resistance of Glioblastoma Stem Cells to Temozolomide

K. Eppert, B. Jean-Claude, J. Rak, 2019, Clinical Cancer Research.

Diverse Roles of Tissue Factor–Expressing Cell Subsets in Tumor Progression

J. Rak, Joanne Yu, N. Magnus, 2008, Seminars in thrombosis and hemostasis.

Extracellular vesicles, tissue factor, cancer and thrombosis – discussion themes of the ISEV 2014 Educational Day

R. Nieuwland, B. Carter, J. Rak, 2015, Journal of extracellular vesicles.

Genetic Basis of Thrombosis in Cancer

J. Rak, Delphine Garnier, B. Meehan, 2014, Seminars in Thrombosis & Hemostasis.

Modulation of the oncogene-dependent tissue factor expression by kinase suppressor of ras 1.

J. Rak, Joanne Yu, C. Milsom, 2010, Thrombosis research.

Role of the tissue factor pathway in the biology of tumor initiating cells.

J. Rak, Delphine Garnier, B. Meehan, 2010, Thrombosis research.

Role of the tissue factor pathway in the biology of tumor initiating cells11Delphine Garnier and Chloe Milsom equally contributed as first authors

J. Rak, Delphine Garnier, B. Meehan, 2010 .

Tissue Factor : Past , Present , and Future Series

J. Rak, Delphine Garnier, B. Meehan, 2010 .

ATVB In Focus Tissue Factor: Past, Present, and Future

J. Rak, Delphine Garnier, B. Meehan, 2010 .

Oncogene-Driven Hemostatic Changes in Cancer

J. Rak, Joanne Yu, C. Milsom, 2009 .

Tissue factor in cancer

J. Rak, Joanne Yu, C. Milsom, 2008, Current opinion in hematology.

Vascular determinants of cancer stem cell dormancy—do age and coagulation system play a role?

J. Rak, Joanne Yu, C. Milsom, 2008, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

Tissue Factor and Cancer

J. Rak, C. Milsom, 2007, Pathophysiology of Haemostasis and Thrombosis.

Emerging anticoagulants: mechanism of action and future potential.

J. Rak, P. Klement, 2006, Vnitrni lekarstvi.

Oncogenes and Tumor Suppressor Genes in Therapeutic Resistance

J. Rak, Joanne Yu, B. Coomber, 2006 .

Regulation of tissue factor and angiogenesis-related genes by changes in cell shape.

J. Rak, C. Milsom, 2005, Biochemical and biophysical research communications.

Extracellular vesicles – vehicles that spread cancer genes

A. Guha, J. Rak, 2012, BioEssays : news and reviews in molecular, cellular and developmental biology.

Biological basis of personalized anticoagulation in cancer: oncogene and oncomir networks as putative regulators of coagulopathy.

J. Rak, E. D’Asti, Esterina D’Asti, 2016, Thrombosis research.

CDK4/6 inhibitors target SMARCA4-determined cyclin D1 deficiency in hypercalcemic small cell carcinoma of the ovary

W. Foulkes, B. Clarke, B. Vanderhyden, 2019, Nature Communications.

Temozolomide Induced Hypermutation in Glioma: Evolutionary Mechanisms and Therapeutic Opportunities

B. Jean-Claude, J. Rak, B. Meehan, 2019, Front. Oncol..

Extracellular Vesicle Mediated Vascular Pathology in Glioblastoma.

D. Choi, J. Rak, L. Adnani, 2021, Sub-cellular biochemistry.

Endothelial expression of autocrine VEGF upon the uptake of tumor-derived microvesicles containing oncogenic EGFR

R. Kerbel, J. Rak, B. Meehan, 2009, Proceedings of the National Academy of Sciences.

Cancer: Organ-seeking vesicles

J. Rak, 2015, Nature.

Tissue factor in tumour progression.

J. Rak, Joanne Yu, N. Magnus, 2009, Best practice & research. Clinical haematology.

In vitro procoagulant activity induced in endothelial cells by chemotherapy and antiangiogenic drug combinations: modulation by lower-dose chemotherapy.

D. Hicklin, R. Kerbel, G. Francia, 2005, Cancer research.

Tissue Factor Regulation by miR-520g in Primitive Neuronal Brain Tumor Cells: A Possible Link between Oncomirs and the Vascular Tumor Microenvironment.

M. Kool, S. Pfister, A. Korshunov, 2016, The American journal of pathology.

cells: implications for tumor progression and angiogenesis Oncogenic events regulate tissue factor expression in colorectal cancer

S. Shirasawa, J. Rak, N. Mackman, 2013 .

Acquisition of anoikis resistance promotes the emergence of oncogenic K-ras mutations in colorectal cancer cells and stimulates their tumorigenicity in vivo.

S. Shirasawa, T. Sasazuki, J. Rak, 2007, Neoplasia.

Ischemia-induced K-ras mutations in human colorectal cancer cells: role of microenvironmental regulation of MSH2 expression.

S. Shirasawa, J. Rak, B. Coomber, 2005, Cancer research.

Ischemia-Induced Kras Mutations in Human Colorectal Cancer Cells : Role of Microenvironmental Regulation of MSH 2 Expression

S. Shirasawa, J. Rak, B. Coomber, 2005 .

Oncogenes and tumor angiogenesis: the question of vascular "supply" and vascular "demand".

J. Rak, Joanne Yu, 2004, Seminars in cancer biology.

Oncogenes as inducers of tumor angiogenesis

R. Kerbel, J. Rak, D. Marmé, 1995, Cancer and Metastasis Reviews.

Angiogenesis and the role of epigenetics in metastasis

J. Rak, Joanne Yu, B. Coomber, 2004, Clinical & Experimental Metastasis.

Oncogene-Directed Therapies

A. Giordano, J. Hickman, L. Kèlland, 2003, Cancer Drug Discovery and Development.

What do oncogenic mutations have to do with angiogenesis/vascular dependence of tumors?

R. Kerbel, J. Rak, Joanne Yu, 2002, Cancer research.

Effect of p53 Status on Tumor Response to Antiangiogenic Therapy

D. Hicklin, R. Kerbel, J. Rak, 2002, Science.

Ras regulation of vascular endothelial growth factor and angiogenesis.

R. Kerbel, J. Rak, 2001, Methods in enzymology.

Oncogenes and angiogenesis: signaling three-dimensional tumor growth.

R. Kerbel, J. Rak, G. Klement, 2000, The journal of investigative dermatology. Symposium proceedings.

'Accidental' anti-angiogenic drugs. anti-oncogene directed signal transduction inhibitors and conventional chemotherapeutic agents as examples.

R. Kerbel, J. Rak, G. Klement, 2000, European journal of cancer.

Collateral expression of proangiogenic and tumorigenic properties in intestinal epithelial cell variants selected for resistance to anoikis.

R. Kerbel, V. A. Flørenes, J. Rak, 1999, Neoplasia.

Establishing a Link between Oncogenes and Tumor Angiogenesis

Robert S. Kerbel, R. Kerbel, J. Rak, 1998, Molecular medicine.

Impact of oncogenes in tumor angiogenesis: mutant K-ras up-regulation of vascular endothelial growth factor/vascular permeability factor is necessary, but not sufficient for tumorigenicity of human colorectal carcinoma cells.

R. Kerbel, S. Shirasawa, T. Sasazuki, 1998, Proceedings of the National Academy of Sciences of the United States of America.

CD44 regulates hematopoietic progenitor distribution, granuloma formation, and tumorigenicity.

T. Mak, T. Kündig, A. Wakeham, 1997, Blood.

Heparin and angiogenesis: size matters!

J. Rak, J. Weitz, 2003, Arteriosclerosis, thrombosis, and vascular biology.

Heterogeneity of Extracellular Vesicles and Particles: Molecular Voxels in the Blood Borne “Hologram” of Organ Function, Disfunction and Cancer

J. Rak, L. Strzadala, 2023, Archivum Immunologiae et Therapiae Experimentalis.

Oncogenic Regulation of Extracellular Vesicle Proteome and Heterogeneity

L. Montermini, D. Choi, J. Rak, 2019, Proteomics.

Extracellular Vesicles as Conduits of Non-Coding RNA Emission and Intercellular Transfer in Brain Tumors

D. Choi, J. Rak, L. Adnani, 2018, Non-coding RNA.

Extracellular vesicle communication pathways as regulatory targets of oncogenic transformation.

D. Choi, J. Rak, E. D’Asti, 2017, Seminars in cell & developmental biology.

Barriers to horizontal cell transformation by extracellular vesicles containing oncogenic H-ras

K. Eppert, L. Montermini, J. Rak, 2016, Oncotarget.

Inhibition of Oncogenic Epidermal Growth Factor Receptor Kinase Triggers Release of Exosome-like Extracellular Vesicles and Impacts Their Phosphoprotein and DNA Content*

L. Montermini, A. Guha, J. Rak, 2015, The Journal of Biological Chemistry.

The contribution of tumor and host tissue factor expression to oncogene-driven gliomagenesis.

L. Montermini, M. Hashemi, J. Rak, 2014, Biochemical and biophysical research communications.

Oncogenes and the coagulation system--forces that modulate dormant and aggressive states in cancer.

J. Rak, Delphine Garnier, B. Meehan, 2014, Thrombosis research.

Interleukin-6 dependent induction of the cyclin dependent kinase inhibitor p21WAF1/CIP1 is lost during progression of human malignant melanoma

R. Kerbel, V. A. Flørenes, J. Slingerland, 1999, Oncogene.

Microvesicles: Messengers and mediators of tumor progression

J. Rak, B. Meehan, K. Al-Nedawi, 2009, Cell cycle.

SMARCA4 loss is synthetic lethal with CDK4/6 inhibition in non-small cell lung cancer

William A. Pastor, W. Foulkes, Sidong Huang, 2019, Nature Communications.

MISEV 2018 ) : a position statement of the International Society for Extracellular Vesicles and update of the MISEV 2014 guidelines

Krisztina V. Vukman, Scott M Langevin, Valentina R Minciacchi, 2018 .

The dormant in vivo phenotype of early stage primary human melanoma: termination by overexpression of vascular endothelial growth factor

R. Kerbel, S. Man, J. Rak, 2004, Angiogenesis.

A disconnect between antitumor and antiangiogenic effects of fluvastatin in vitro and in vivo.

J. Rak, H. Klement, 2006, Neoplasma.

Restoration of thrombospondin 1 expression in tumor cells harbouring mutant ras oncogene by treatment with low doses of doxycycline.

P. Bornstein, J. Rak, Joanne Yu, 2003, Biochemical and biophysical research communications.

Reciprocal paracrine interactions between tumour cells and endothelial cells: the 'angiogenesis progression' hypothesis.

R. Kerbel, J. Rak, J. Filmus, 1996, European journal of cancer.

Endogenous interleukin 6 can function as an in vivo growth- stimulatory factor for advanced-stage human melanoma cells.

R. Kerbel, J. Rak, N. Hozumi, 1996, Clinical cancer research : an official journal of the American Association for Cancer Research.

Multiple features of advanced melanoma recapitulated in tumorigenic variants of early stage (radial growth phase) human melanoma cell lines: evidence for a dominant phenotype.

J. Trent, R. Kerbel, J. Rak, 1996, Cancer research.

Human multipotent mesenchymal stromal cells cytokine priming promotes RAB27B-regulated secretion of small extracellular vesicles with immunomodulatory cargo

D. Choi, J. Rak, D. Shum-Tim, 2020, Stem cell research & therapy.

L(C3)icensing of exosomes for RNA export

J. Rak, 2020, Nature Cell Biology.

Leukobiopsy – A Possible New Liquid Biopsy Platform for Detecting Oncogenic Mutations

J. Rak, S. Chennakrishnaiah, Saro Aprikian, 2020, Frontiers in Pharmacology.

Marked induction of the IAP family antiapoptotic proteins survivin and XIAP by VEGF in vascular endothelial cells.

R. Kerbel, J. Rak, R. Korneluk, 1999, Biochemical and biophysical research communications.

Coagulation and angiogenic gene expression profiles are defined by molecular subgroups of medulloblastoma: evidence for growth factor‐thrombin cross‐talk

M. Kool, S. Pfister, J. Rak, 2014, Journal of thrombosis and haemostasis : JTH.

Activated ras Prevents Downregulation of Bcl-XL Triggered by Detachment from the Extracellular Matrix

R. Kerbel, J. Rak, N. Dean, 2000, The Journal of cell biology.

Oncogenes and tumor angiogenesis: differential modes of vascular endothelial growth factor up-regulation in ras-transformed epithelial cells and fibroblasts.

N. Ahn, R. Kerbel, J. Rak, 2000, Cancer Research.

- transformed Epithelial Cells and Fibroblasts ras Vascular Endothelial Growth Factor Up-Regulation in Oncogenes and Tumor Angiogenesis : Differential Modes of Updated

N. Ahn, R. Kerbel, J. Rak, 2000 .

Activated Ras prevents downregulation of Bcl-X(L) triggered by detachment from the extracellular matrix. A mechanism of Ras-induced resistance to anoikis in intestinal epithelial cells.

R. Kerbel, J. Rak, N. Dean, 2000, The Journal of cell biology.

Oncogenes and Tumor Angiogenesis : Differential Modes of Vascular Endothelial Growth Factor Up-Regulation in ras-transformed Epithelial Cells and Fibroblasts 1

N. Ahn, R. Kerbel, J. Rak, 2000 .

Is cancer stem cell a cell, or a multicellular unit capable of inducing angiogenesis?

J. Rak, 2006, Medical hypotheses.

Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity

Peter Bohlen, Robert S. Kerbel, S. Baruchel, 2000 .

Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity.

S. Baruchel, D. Hicklin, P. Bohlen, 2000, The Journal of clinical investigation.

Dynamic stromal‐epithelial interactions during progression of MCF10DCIS.com xenografts

H. Heng, J. Rak, F. Miller, 2007, International journal of cancer.

Possible Mechanisms of Acquired Resistance to Anti-angiogenic Drugs: Implications for the Use of Combination Therapy Approaches

R. Kerbel, S. Man, J. Rak, 2004, Cancer and Metastasis Reviews.

SMARCB1 loss induces druggable cyclin D1 deficiency via upregulation of MIR17HG in atypical teratoid rhabdoid tumors

M. O'sullivan, W. Foulkes, J. Pelletier, 2020, The Journal of pathology.

Multicellular gastric cancer spheroids recapitulate growth pattern and differentiation phenotype of human gastric carcinomas.

R. Kerbel, B. Mayer, S. Man, 2001, Gastroenterology.

Tissue factor expression provokes escape from tumor dormancy and leads to genomic alterations

G. Bourque, J. Rak, M. Caron, 2014, Proceedings of the National Academy of Sciences.

Mutant ras oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumor angiogenesis.

R. Kerbel, S. Shirasawa, T. Sasazuki, 1995, Cancer research.

Carrying Tissue Factor Exosome-like Extracellular Vesicles Mesenchymal Phenotype Release Cancer Cells Induced to Express Molecular Bases of Disease:

L. Montermini, J. Rak, Delphine Garnier, 2013 .

Acquired resistance to the antitumor effect of epidermal growth factor receptor-blocking antibodies in vivo: a role for altered tumor angiogenesis.

D. Hicklin, P. Bohlen, R. Kerbel, 2001, Cancer research.

Qualitative changes in the proteome of extracellular vesicles accompanying cancer cell transition to mesenchymal state.

T. Kislinger, J. Rak, Delphine Garnier, 2013, Experimental cell research.

Treating cancer by inhibiting angiogenesis: new hopes and potential pitfall

R. Kerbel, J. Rak, 1996, Cancer and Metastasis Reviews.

Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: angiogenic implications for signal transduction therapy of solid tumors.

N. Goldstein, M. Hung, R. Kerbel, 1997, The American journal of pathology.

The Role of Angiogenesis in Tumor Progression and Metastasis

R. Kerbel, J. Rak, E. J. Hegmann, 1993 .

RB2/p130 gene-enhanced expression down-regulates vascular endothelial growth factor expression and inhibits angiogenesis in vivo.

P. Stiegler, R. Kerbel, A. Giordano, 2001, Cancer research.

Advances in Brief RB 2 / p 130 Gene-enhanced Expression Down-Regulates Vascular Endothelial Growth Factor Expression and Inhibits Angiogenesis in Vivo 1

P. Stiegler, R. Kerbel, A. Giordano, 2001 .

J. Rak, Delphine Garnier, B. Meehan, 2014, Mechanisms of Ageing and Development.

Primary Thromboprophylaxis in Pancreatic Cancer Patients: Why Clinical Practice Guidelines Should Be Implemented

E. Vicaut, T. Conroy, J. Rak, 2020, Cancers.

New technologies for the detection of circulating tumour cells.

Nada Jabado, J. Rak, N. Gerges, 2010, British medical bulletin.

A reference map of the human binary protein interactome

Gary D Bader, István A. Kovács, Robert J. Weatheritt, 2020, Nature.

Interleukin 6 in progression of human solid tumors : transitional changes in the regulation of cell growth, apoptosis and angiogenesis

R. Kerbel, J. Rak, Chao Lu, 1997 .

Influence of Hypoxia on Radiosensitization of Cancer Cells by 5-Bromo-2′-deoxyuridine

J. Rak, A. Herman-Antosiewicz, Aleksandra Hać, 2022, International journal of molecular sciences.

Consequences of angiogenesis for tumor progression, metastasis and cancer therapy.

R. Kerbel, J. Rak, B. S. Croix, 1995, Anti-cancer drugs.

Extracellular vesicles from genetically unstable, oncogene-driven cancer cells trigger micronuclei formation in endothelial cells

L. Montermini, S. Mai, D. Choi, 2020, Scientific Reports.

Heterogeneous vascular dependence of tumor cell populations.

P. Carmeliet, R. Kerbel, A. Nagy, 2001, The American journal of pathology.

Genetic and epigenetic regulation of cancer coagulome - lessons from heterogeneity of cancer cell populations.

J. Rak, N. Tawil, C. Spinelli, 2020, Thrombosis research.

Reversal by hyaluronidase of adhesion-dependent multicellular drug resistance in mammary carcinoma cells.

R. Kerbel, J. Rak, B. S. Croix, 1996, Journal of the National Cancer Institute.

bFGF and tumor angiogenesis — Back in the limelight?

R. Kerbel, J. Rak, 1997, Nature Medicine.

Basic fibroblast growth factor and the complexity of tumour angiogenesis.

R. Kerbel, J. Rak, 1998, Expert opinion on investigational drugs.

on Tumor Initiation and Angiogenesis Receptor and Epithelial-to-Mesenchymal Transitions : Effect Tissue Factor Regulation by Epidermal Growth Factor

A. Guha, J. Rak, N. Mackman, 2008 .

Impact of Oncogenes and Tumor Suppressor Genes on Deregulation of Hemostasis and Angiogenesis in Cancer

J. Rak, G. Klement, 2004, Cancer and Metastasis Reviews.

Anthracycline-containing chemotherapy causes long-term impairment of mitochondrial respiration and increased reactive oxygen species release in skeletal muscle

Fennigje M. Purves-Smith, J. Rak, G. Gouspillou, 2015, Scientific Reports.

PML–RARa modulates the vascular signature of extracellular vesicles released by acute promyelocytic leukemia cells

L. Montermini, J. Rak, Yi Fang, 2015, Angiogenesis.

Oncogenic ras-driven cancer cell vesiculation leads to emission of double-stranded DNA capable of interacting with target cells.

L. Montermini, J. Rak, B. Meehan, 2014, Biochemical and biophysical research communications.

Complement cascade gene expression defines novel prognostic subgroups of acute myeloid leukemia.

W. Hiddemann, K. Eppert, S. Bohlander, 2016, Experimental hematology.

Downregulation of the angiogenesis inhibitor thrombospondin 1 in fibroblasts exposed to platelets and their related phospholipids.

J. Rak, P. Klement, W. Kałas, 2005, Biochemical and biophysical research communications.

Thrombospondin-1 receptor mediates autophagy of RAS-expressing cancer cells and triggers tumour growth inhibition.

J. Rak, J. Wietrzyk, M. Świtalska, 2013, Anticancer research.

Heparin and Angiogenesis

J. Rak, J. Weitz, 2003 .

Low-dose metronomic cyclophosphamide treatment mediates ischemia-dependent K-ras mutation in colorectal carcinoma xenografts

S. Shirasawa, T. Sasazuki, J. Rak, 2008, Oncogene.

Autoantibodies against the cell surface–associated chaperone GRP78 stimulate tumor growth via tissue factor

S. Pizzo, W. Arap, J. Rak, 2017, The Journal of Biological Chemistry.

Microvesicles as mediators of intercellular communication in cancer—the emerging science of cellular ‘debris’

J. Rak, B. Meehan, E. D’Asti, 2011, Seminars in Immunopathology.

VEGF-D(ilated) lymphatics as gateways to metastasis.

J. Rak, 2012, Cancer cell.

Contrasting effects of VEGF gene disruption in embryonic stem cell‐derived versus oncogene‐induced tumors

R. Kerbel, C. Lobe, J. Henkin, 2003, The EMBO journal.

Oncogene-dependent survival of highly transformed cancer cells under conditions of extreme centrifugal force – implications for studies on extracellular vesicles

J. Rak, S. Chennakrishnaiah, T. Lee, 2015, Cellular & molecular biology letters.

Isolation of Extracellular Vesicles for Proteomic Profiling.

Y. Gho, D. Choi, J. Rak, 2021, Methods in molecular biology.

Rational Development of Liquid Biopsy Analysis in Renal Cell Carcinoma

F. Brimo, L. Montermini, J. Rak, 2021, Cancers.

PML–RARa modulates the vascular signature of extracellular vesicles released by acute promyelocytic leukemia cells

L. Montermini, J. Rak, Yi Fang, 2015, Angiogenesis.

Epidemiology, biology, and management of venous thromboembolism in gliomas: An interdisciplinary review.

D. Schiff, C. Horbinski, J. Rak, 2023, Neuro-oncology.

Arteriogenic expansion of extratumoral macrovessels - impact of vascular ageing.

J. Rak, B. Meehan, N. Magnus, 2015, Neoplasma.

Functional dissociation of anoikis-like cell death and activity of stress activated protein kinase.

R. Kerbel, J. Rak, J. Filmus, 1999, Biochemical and biophysical research communications.

CDK4/6 inhibitors target SMARCA4-determined cyclin D1 deficiency in hypercalcemic small cell carcinoma of the ovary

W. Foulkes, B. Clarke, B. Vanderhyden, 2019, Nature Communications.

H-ras up-regulates expression of BNIP3.

J. Rak, A. Rapak, W. Kałas, 2011, Anticancer research.

H-ras Upregulates Expression of BNIP 3

J. Rak, A. Rapak, W. Kałas, 2011 .

Cell line specific abnormalities in expression of PNA, SBA and L-PHA binding sites by carcinogen induced rat urothelial carcinomas.

M. Debiec‐Rychter, J. Rak, F. Miller, 1992, Neoplasma.

Plasmonic nanobowtiefluidic device for sensitive detection of glioma extracellular vesicles by Raman spectrometry.

L. Montermini, J. Rak, Imman Isaac Hosseini, 2021, Lab on a chip.

Heterogeneity of Extracellular Vesicles and Particles: Molecular Voxels in the Blood Borne “Hologram” of Organ Function, Disfunction and Cancer

J. Rak, L. Strzadala, 2023, Archivum Immunologiae et Therapiae Experimentalis.

Extracellular Vesicles in Brain Tumor Progression

J. Rak, E. D’Asti, S. Chennakrishnaiah, 2016, Cellular and Molecular Neurobiology.

Radiosensitization of PC3 Prostate Cancer Cells by 5-Thiocyanato-2′-deoxyuridine

J. Rak, M. Rychłowski, Magdalena Zdrowowicz, 2022, Cancers.

Cell Surface GRP78: A Novel Regulator of Tissue Factor Procoagulant Activity

J. Rak, R. Austin, Ali A. Al-Hashimi, 2018 .

MoS2-Plasmonic Nanocavities for Raman Spectra of Single Extracellular Vesicles Reveal Molecular Progression in Glioblastoma

S. Wachsmann-Hogiu, L. Montermini, J. Rak, 2023, ACS nano.

Atherosclerosis and vascular aging as modifiers of tumor progression, angiogenesis, and responsiveness to therapy.

J. Rak, B. St. Croix, Joanne Yu, 2007, The American journal of pathology.

Blood coagulation and cancer genes.

J. Rak, N. Tawil, Nadim Tawil, 2022, Best practice & research. Clinical haematology.

Inhibition of tissue factor signaling in breast tumour xenografts induces widespread changes in the microRNA expression profile.

J. Rak, Janusz Rak, G. Anderson, 2017, Biochemical and biophysical research communications.

Brain Neoplasms and Coagulation—Lessons from Heterogeneity

J. Rak, Yi Fang, E. D’Asti, 2014, Rambam Maimonides medical journal.

Inflammatory Mediators of Angiogenesis

J. Rak, G. Szewczyk, J. Ruth, 2013, Mediators of inflammation.

Nanofluidics for Simultaneous Size and Charge Profiling of Extracellular Vesicles.

L. Montermini, J. Rak, I. I. Hosseini, 2021, Nano letters.

SMARCA4 loss is synthetic lethal with CDK4/6 inhibition in non-small cell lung cancer

William A. Pastor, W. Foulkes, Sidong Huang, 2019, Nature Communications.

Contribution of Host-Derived Tissue Factor to Tumor Neovascularization

J. Rak, J. Luyendyk, N. Mackman, 2008, Arteriosclerosis, thrombosis, and vascular biology.

Oncogenes and Tumor Angiogenesis

R. Kerbel, J. Rak, 2004 .

Host microenvironment in breast cancer development: Inflammatory and immune cells in tumour angiogenesis and arteriogenesis

J. Rak, Joanne Yu, 2003, Breast Cancer Research.

A reference map of the human binary protein interactome

Patrick Aloy, Gary D. Bader, Yang Wang, 2020, Nature.

Oncogenes and the coagulation system--forces that modulate dormant and aggressive states in cancer.

J. Rak, Delphine Garnier, B. Meehan, 2014, Thrombosis research.

Tissue Factor Regulation by miR-520g in Primitive Neuronal Brain Tumor Cells: A Possible Link between Oncomirs and the Vascular Tumor Microenvironment.

M. Kool, S. Pfister, A. Korshunov, 2016, The American journal of pathology.