D. Handy

J. Loscalzo, D. Handy, Kenneth Lim, 2018, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

α2 Adrenergic Receptor Subtypes Expressed in Chinese Hamster Ovary Cells Activate Differentially Mitogen-activated Protein Kinase by a p21ras Independent Pathway (*)

H. Gavras, D. Handy, G. Béréziat, 1995, The Journal of Biological Chemistry.

Comparison of Protein N-Homocysteinylation in Rat Plasma under Elevated Homocysteine Using a Specific Chemical Labeling Method

J. Loscalzo, D. Handy, Shujia Dai, 2016, Molecules.

Homocysteine induces cardiomyocyte dysfunction and apoptosis through p38 MAPK-mediated increase in oxidant stress.

J. Loscalzo, R. Liao, D. Handy, 2012, Journal of molecular and cellular cardiology.

Increasing Glucose 6-Phosphate Dehydrogenase Activity Restores Redox Balance in Vascular Endothelial Cells Exposed to High Glucose

J. Loscalzo, D. Handy, C. Liew, 2012, PloS one.

Cloning and expression of a rat brain a 2 B-adrenergic receptor ( a 2-adrenergic receptor subtypes / cDNA / [ 3 H ] rauwolscine / antisense mRNA )

H. Gavras, D. Handy, M. Bresnahan, 2022 .

A Type 2 Deiodinase-Dependent Increase in Vegfa Mediates Myoblast-Endothelial Cell Crosstalk During Skeletal Muscle Regeneration.

P. Larsen, D. Handy, S. Wajner, 2020, Thyroid : official journal of the American Thyroid Association.

Hyperhomocysteinemia from trimethylation of hepatic phosphatidylethanolamine during cholesterol cholelithogenesis in inbred mice

J. Loscalzo, D. Handy, J. Selhub, 2011, Hepatology.

Sympathoinhibitory Function of the α2A-Adrenergic Receptor Subtype

H. Gavras, D. Handy, I. Gavras, 1999 .

Localization of α2A- and α2B-Adrenergic Receptor Subtypes in Brain

H. Gavras, D. Rosene, D. Handy, 1996 .

Both selenium deficiency and modest selenium supplementation lead to myocardial fibrosis in mice via effects on redox-methylation balance.

J. Loscalzo, D. Handy, D. Jacobsen, 2012, Molecular nutrition & food research.

Promoter region of the human alpha 2A adrenergic receptor gene.

H. Gavras, D. Handy, 1992, The Journal of biological chemistry.

Systems Pharmacology and Rational Polypharmacy: Nitric Oxide−Cyclic GMP Signaling Pathway as an Illustrative Example and Derivation of the General Case

Yang-Yu Liu, Joseph Loscalzo, Farshid S. Garmaroudi, 2016, PLoS Comput. Biol..

Hyperhomocysteinemia: the protein C pathway to thrombosis

D. Handy, 2006 .

Glutathione peroxidase-1 in health and disease: from molecular mechanisms to therapeutic opportunities.

J. Loscalzo, E. Lubos, D. Handy, 2011, Antioxidants & redox signaling.

Role of the postsynaptic alpha(2)-adrenergic receptor subtypes in catecholamine-induced vasoconstriction.

H. Gavras, D. Handy, I. Gavras, 2000, General pharmacology.

Role of oxidative stress and nitric oxide in atherothrombosis.

J. Loscalzo, E. Lubos, D. Handy, 2008, Frontiers in bioscience : a journal and virtual library.

Selenoprotein Gene Nomenclature*

R. Guigó, S. Castellano, G. Kryukov, 2016, The Journal of Biological Chemistry.

Redox regulation in the extracellular environment.

J. Loscalzo, D. Handy, Filomena Ottaviano, 2008, Circulation journal : official journal of the Japanese Circulation Society.

Selenium supplementation improves antioxidant capacity in vitro and in vivo in patients with coronary artery disease The SElenium Therapy in Coronary Artery disease Patients (SETCAP) Study.

R. Schnabel, S. Blankenberg, J. Loscalzo, 2008, American heart journal.

Associations of methyl donor and methylation inhibitor levels during anti-oxidant therapy in heart failure

J. Loscalzo, D. Mann, A. Cheema, 2021, Journal of physiology and biochemistry.

Elevated levels of homocysteine compromise blood-brain barrier integrity in mice.

J. Loscalzo, A. Chauhan, D. Wagner, 2005, Blood.

Redox regulation of mitochondrial function.

Joseph Loscalzo, Diane E Handy, J. Loscalzo, 2012, Antioxidants & redox signaling.

Aminoglycosides Decrease Glutathione Peroxidase-1 Activity by Interfering with Selenocysteine Incorporation*

J. Loscalzo, D. Handy, Yi Yang, 2006, Journal of Biological Chemistry.

The Link Between Hyperhomocysteinemia and Hypomethylation: Implications for Cardiovascular Disease

R. Castro, Madalena Barroso, D. Handy, 2017 .

Comprehensive network medicine-based drug repositioning via integration of therapeutic efficacy and side effects

J. Loscalzo, L. Farina, P. Paci, 2022, npj Systems Biology and Applications.

Signals controlling alternative splicing of major histocompatibility complex H-2 class I pre-mRNA

J. Coligan, D. Margulies, J. McCluskey, 2004, Immunogenetics.

Glutathione Peroxidase-1 Deficiency Augments Proinflammatory Cytokine-induced Redox Signaling and Human Endothelial Cell Activation*

Neil J Kelly, J. Loscalzo, E. Lubos, 2011, Journal of Biological Chemistry.

Evidence for cell-specific regulation of transcription of the rat alpha2A-adrenergic receptor gene.

H. Gavras, D. Handy, 1996, Hypertension.

Early pregnancy vitamin D status and risk of preeclampsia.

Amitabh Sharma, G. O'Connor, J. Loscalzo, 2016, The Journal of clinical investigation.

Homocysteine and glutathione peroxidase-1.

J. Loscalzo, E. Lubos, D. Handy, 2007, Antioxidants & redox signaling.

Bone Morphogenetic Protein‐2 Decreases MicroRNA‐30b and MicroRNA‐30c to Promote Vascular Smooth Muscle Cell Calcification

J. Loscalzo, R. Hajjar, D. Handy, 2012, Journal of the American Heart Association.

Cloning and expression of a rat brain alpha 2B-adrenergic receptor.

H. Gavras, D. Handy, C. Flordellis, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Homocysteine Down-regulates Cellular Glutathione Peroxidase (GPx1) by Decreasing Translation*

J. Loscalzo, D. Handy, Yufeng Zhang, 2005, Journal of Biological Chemistry.

Autosomal dominant orthostatic hypotensive disorder maps to chromosome 18q.

L. Farrer, H. Gavras, A. DeStefano, 1998, American journal of human genetics.

Interferon-γ Impairs Human Coronary Artery Endothelial Glucose Metabolism by Tryptophan Catabolism and Activates Fatty Acid Oxidation

J. Loscalzo, D. Handy, W. Oldham, 2021, Circulation.

Epigenetic Modifications: Basic Mechanisms and Role in Cardiovascular Disease (2013 Grover Conference Series)

J. Loscalzo, D. Handy, 2014, Pulmonary circulation.

Impaired Angiogenesis in Glutathione Peroxidase-1–Deficient Mice Is Associated With Endothelial Progenitor Cell Dysfunction

J. Loscalzo, D. Handy, G. Galasso, 2006, Circulation research.

Models of experimental hypertension in mice.

H. Gavras, D. Handy, I. Gavras, 1996, Hypertension.

Glucose-6-Phosphate Dehydrogenase Deficiency Decreases Vascular Superoxide and Atherosclerotic Lesions in Apolipoprotein E−/− Mice

J. Loscalzo, D. Handy, R. Cohen, 2006, Arteriosclerosis, thrombosis, and vascular biology.

High glucose–induced ubiquitination of G6PD leads to the injury of podocytes

Chuanming Hao, D. Handy, Qinghua Wang, 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

High glucose-induced ubiquitylation of G6PD leads to the injury of podocyte

Chuanming Hao, R. Hu, D. Handy, 2018, bioRxiv.

Glucose-6-phosphate dehydrogenase-deﬁcient mice have increased renal oxidative stress and increased albuminuria

J. Loscalzo, D. Handy, I. Stillman, 2022 .

Glucose-6 Phosphate Dehydrogenase Deficiency Decreases the Vascular Response to Angiotensin II

J. Loscalzo, D. Handy, R. Cohen, 2005, Circulation.

Increased Myocardial Dysfunction After Ischemia-Reperfusion in Mice Lacking Glucose-6-Phosphate Dehydrogenase

J. Loscalzo, Mohit M. Jain, R. Liao, 2004, Circulation.

Glucose-6-phosphate Dehydrogenase Increased Myocardial Dysfunction after Ischemia-reperfusion in Mice Lacking Increased Myocardial Dysfunction after Ischemia-reperfusion in Mice Lacking Glucose-6-phosphate Dehydrogenase

Mohit M. Jain, R. Liao, D. Handy, 2022 .

Role of Promoter Polymorphisms in the Plasma Glutathione Peroxidase (GPx-3) Gene as a Risk Factor for Cerebral Venous Thrombosis

Joyce M Annichino-Bizacchi, J. Loscalzo, D. Handy, 2008, Stroke.

Promoter Polymorphisms in the Plasma Glutathione Peroxidase (GPx-3) Gene: A Novel Risk Factor for Arterial Ischemic Stroke Among Young Adults and Children

Benito P Damasceno, Joseph Loscalzo, Barbara Voetsch, 2007, Stroke.

Determinants of Human Plasma Glutathione Peroxidase (GPx-3) Expression*

J. Loscalzo, D. Handy, B. Voetsch, 2004, Journal of Biological Chemistry.

Identification of a polymorphic glutamic acid stretch in the alpha2B-adrenergic receptor and lack of linkage with essential hypertension.

L. Farrer, H. Gavras, A. DeStefano, 1999, American journal of hypertension.

Homocysteine and atherothrombosis: Diagnosis and treatment

J. Loscalzo, D. Handy, 2003, Current atherosclerosis reports.

Inhibition of Cellular Methyltransferases Promotes Endothelial Cell Activation by Suppressing Glutathione Peroxidase 1 Protein Expression*

R. Castro, Madalena Barroso, I. T. de Almeida, 2014, The Journal of Biological Chemistry.

Both maximal expression of selenoproteins and selenoprotein deficiency can promote development of type 2 diabetes-like phenotype in mice.

J. Loscalzo, V. Gladyshev, D. Hatfield, 2011, Antioxidants & redox signaling.

High-resolution imaging of selenium in kidneys: a localized selenium pool associated with glutathione peroxidase 3.

J. Loscalzo, V. Gladyshev, B. Carlson, 2012, Antioxidants & redox signaling.

Regulation of the extracellular antioxidant selenoprotein plasma glutathione peroxidase (GPx-3) in mammalian cells

J. Loscalzo, D. Handy, Shiow‐Shih Tang, 2009, Molecular and Cellular Biochemistry.

Epigenetics and the Regulation of Nitric Oxide

J. Loscalzo, D. Handy, 2017 .

Associations of methyl donor and methylation inhibitor levels during anti-oxidant therapy in heart failure

J. Loscalzo, D. Mann, A. Cheema, 2021, Journal of Physiology and Biochemistry.

Network-based approach to prediction and population-based validation of in silico drug repurposing

A. Barabasi, S. Schneeweiss, F. Cheng, 2018, Nature Communications.

Corrigendum: Aldosterone impairs vascular reactivity by decreasing glucose-6-phosphate dehydrogenase activity

J. Loscalzo, B. Pitt, R. Liao, 2009, Nature Network Boston.

Role of the α2B-Adrenergic Receptor in the Development of Salt-Induced Hypertension

H. Gavras, B. Kobilka, D. Handy, 1999 .

Role of the alpha2B-adrenergic receptor in the development of salt-induced hypertension.

H. Gavras, B. Kobilka, D. Handy, 1999, Hypertension.

Regulation of α2-adrenoceptors in human vascular smooth muscle cells

S. Flavahan, N. Flavahan, D. Handy, 2004 .

Gene expression of catecholaminergic receptors in the central nervous system of hypertensive rats.

H. Gavras, M. Castellano, D. Handy, 1991, Journal of hypertension. Supplement : official journal of the International Society of Hypertension.

Identification of a human salivary amylase gene. Partial sequence of genomic DNA suggests a mode of regulation different from that of mouse, Amy1.

D. Handy, M. Hodes, R. C. Karn, 1987, Molecular biology & medicine.

A negative regulatory element in the promoter region of the rat alpha 2A-adrenergic receptor gene overlaps an SP1 consensus binding site.

H. Gavras, D. Handy, C. Flordellis, 1995, Biochemical Journal.

Epigenetic modifications: basic mechanisms and role in cardiovascular disease.

R. Castro, J. Loscalzo, D. Handy, 2011, Circulation.

Localization of alpha 2A- and alpha 2B-adrenergic receptor subtypes in brain.

H. Gavras, D. Rosene, D. Handy, 1996, Hypertension.

Hyperhomocysteinemia from trimethylation of hepatic phosphatidylethanolamine during cholesterol cholelithogenesis in inbred mice

J. Loscalzo, D. Handy, J. Selhub, 2011, Hepatology.

Epigenetic Modifications: Basic Mechanisms and Role in Cardiovascular Disease (2013 Grover Conference Series)

J. Loscalzo, D. Handy, 2014, Pulmonary circulation.

Determinants of Human Plasma Glutathione Peroxidase (GPx-3) Expression*

J. Loscalzo, D. Handy, B. Voetsch, 2004, Journal of Biological Chemistry.

Tumor necrosis factor-α-mediated suppression of dual-specificity phosphatase 4: crosstalk between NFκB and MAPK regulates endothelial cell survival

J. Loscalzo, E. Lubos, D. Handy, 2013, Molecular and Cellular Biochemistry.

The Short N-terminal Domains of STIM1 and STIM2 Control the Activation Kinetics of Orai1 Channels*

D. Handy, Joseph Loscalzo, Gaozhen Hang, 2006, The Journal of Biological Chemistry.

L-arginine increases plasma homocysteine in apoE-/-/iNOS-/- double knockout mice.

J. Loscalzo, D. Handy, J. Chen, 2004, Cellular and molecular biology.