P. Reynier

J. Martinou, D. Bonneau, P. Amati‐Bonneau, 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Increased mitochondrial fusion in a autosomal recessive CMT2A family with mitochondrial GTPase mitofusin 2 mutations

D. Bonneau, G. Lenaers, P. Reynier, 2016, Journal of the peripheral nervous system : JPNS.

MFN2, a new gene responsible for mitochondrial DNA depletion.

P. Amati‐Bonneau, P. Reynier, D. Rodriguez, 2012, Brain : a journal of neurology.

Maternal ageing impairs mitochondrial DNA kinetics during early embryogenesis in mic.

V. Desquiret-Dumas, P. Reynier, V. Duranthon, 2019, Human reproduction.

Use of Next-Generation Sequencing for the Molecular Diagnosis of 1,102 Patients With a Autosomal Optic Neuropathy

C. Bris, D. Goudenège, V. Desquiret-Dumas, 2021, Frontiers in Neurology.

Increased steroidogenesis promotes early-onset and severe vision loss in females with OPA1 dominant optic atrophy.

M. Larsen, D. Milea, G. Lenaers, 2016, Human molecular genetics.

Relationship between diminished ovarian reserve and mitochondrial biogenesis in cumulus cells.

P. Reynier, V. Procaccio, J. M. C. Barca, 2015, Human reproduction.

Ethambutol-induced optic neuropathy linked to OPA1 mutation and mitochondrial toxicity.

D. Bonneau, P. Amati‐Bonneau, P. Reynier, 2010, Mitochondrion.

Reversible optic neuropathy with OPA1 exon 5b mutation

D. Wallace, D. Milea, D. Bonneau, 2008, Annals of neurology.

OPA3 gene mutations responsible for autosomal dominant optic atrophy and cataract

P. Calvas, D. Bonneau, P. Amati‐Bonneau, 2004, Journal of Medical Genetics.

Recessive Mutations in RTN4IP1 Cause Isolated and Syndromic Optic Neuropathies.

B. Lorenz, P. Chinnery, P. Yu-Wai-Man, 2015, American Journal of Human Genetics.

Mitochondrial DNA A3243G mutation involved in familial diabetes, chronic intestinal pseudo-obstruction and recurrent pancreatitis.

D. Bonneau, P. Amati‐Bonneau, P. Reynier, 2008, Diabetes & metabolism.

Idebenone increases mitochondrial complex I activity in fibroblasts from LHON patients while producing contradictory effects on respiration

D. Milea, V. Desquiret-Dumas, D. Bonneau, 2011, BMC Research Notes.

Warburg-like effect is a hallmark of complex I assembly defects.

D. Goudenège, V. Desquiret-Dumas, D. Bonneau, 2019, Biochimica et biophysica acta. Molecular basis of disease.

Never too old to harbour a young man's disease?

D. Milea, D. Bonneau, P. Amati‐Bonneau, 2010, British Journal of Ophthalmology.

The association of autosomal dominant optic atrophy and moderate deafness may be due to the R445H mutation in the OPA1 gene.

L. Pasquier, D. Bonneau, P. Amati‐Bonneau, 2003, American journal of ophthalmology.

Perspectives of drug-based neuroprotection targeting mitochondria.

C. Bris, D. Bonneau, P. Amati‐Bonneau, 2014, Revue neurologique.

Updated review of postmortem biochemical exploration of hypothermia with a presentation of standard strategy of sampling and analyses

P. Reynier, C. Palmiere, G. Rousseau, 2018, Clinical chemistry and laboratory medicine.

Metabolic Profile and Pathological Alterations in the Muscle of Patients with Early-Stage Amyotrophic Lateral Sclerosis

P. Reynier, P. Vourc'h, C. Andres, 2022, Biomedicines.

Mutations in the m-AAA proteases AFG3L2 and SPG7 are causing isolated dominant optic atrophy

M. Votruba, C. La Morgia, P. Yu-Wai-Man, 2020, Neurology: Genetics.

Mutation of OPA1 causes dominant optic atrophy with external ophthalmoplegia, ataxia, deafness and multiple mitochondrial DNA deletions: a novel disorder of mtDNA maintenance.

Robert W. Taylor, D. Turnbull, P. Chinnery, 2008, Brain : a journal of neurology.

Next-Generation Sequencing Identifies Novel PMPCA Variants in Patients with Late-Onset Dominant Optic Atrophy

C. Bris, D. Goudenège, V. Desquiret-Dumas, 2022, Genes.

Sensorineural hearing loss in OPA1-linked disorders.

M. Larsen, D. Milea, E. Colin, 2013, Brain : a journal of neurology.

Heterozygous OPA1 mutations in Behr syndrome.

A. Durr, A. Brice, G. Stevanin, 2011, Brain : a journal of neurology.

The mitochondrial DNA content of cumulus granulosa cells is linked to embryo quality

V. Desquiret-Dumas, P. Reynier, V. Procaccio, 2017, Human reproduction.

Acute intermittent porphyria causes hepatic mitochondrial energetic failure in a mouse model.

V. Desquiret-Dumas, P. Reynier, T. Lefèbvre, 2014, The international journal of biochemistry & cell biology.

Mitochondrial DNA Instability Is Common in HIV-Exposed Uninfected Newborns

J. Molès, C. Bris, D. Goudenège, 2021, Journal of clinical medicine.

Glutamate-Induced Deregulation of Krebs Cycle in Mitochondrial Encephalopathy Lactic Acidosis Syndrome Stroke-Like Episodes (MELAS) Syndrome Is Alleviated by Ketone Body Exposure

C. Bris, D. Goudenège, V. Desquiret-Dumas, 2022, Biomedicines.

Mitochondrial DNA Parameters in Blood of Infants Receiving Lopinavir/Ritonavir or Lamivudine Prophylaxis to Prevent Breastfeeding Transmission of HIV-1

J. Molès, P. Reynier, C. Kankasa, 2020, Journal of clinical medicine.

Mitochondrial activity in XTC.UC1 cells derived from thyroid oncocytoma.

P. Reynier, F. Savagner, A. Chevrollier, 2001, Thyroid : official journal of the American Thyroid Association.

The cytokine profile of follicular fluid changes during ovarian ageing.

P. Reynier, V. Procaccio, J. M. C. de la Barca, 2020, Journal of gynecology obstetrics and human reproduction.

Sickle Cell Disease: Metabolomic Profiles of Vaso-Occlusive Crisis in Plasma and Erythrocytes

P. Reynier, C. Veyrat-Durebex, C. Homedan, 2020, Journal of clinical medicine.

Discordant Predictions of Extraglandular Involvement in Primary Sjögren’s Syndrome According to the Anti-SSA/Ro60 Antibodies Detection Assay in a Cohort Study

P. Reynier, A. Chevailler, C. Lavigne, 2022, Journal of clinical medicine.

A randomized, double‐blind, placebo‐controlled trial evaluating cysteamine in Huntington's disease

A. Durr, P. Krystkowiak, A. Bachoud-Lévi, 2017, Movement disorders : official journal of the Movement Disorder Society.

Mitochondrial DNA in the oocyte and the developing embryo.

P. Reynier, Y. Malthiéry, P. May-Panloup, 2007, Current topics in developmental biology.

Mitochondrial DNA content affects the fertilizability of human oocytes.

P Barrière, P. Reynier, P. Barrière, 2001, Molecular human reproduction.

Embryo and Its Mitochondria

P. Reynier, P. May-Panloup, P. Bouet, 2021, Antioxidants.

Ovarian ageing: the role of mitochondria in oocytes and follicles.

V. Desquiret-Dumas, P. Reynier, V. Procaccio, 2016, Human reproduction update.

Mitochondrial bioenergetic background confers a survival advantage to HepG2 cells in response to chemotherapy

D. Morvan, A. Demidem, P. Reynier, 2009, Molecular carcinogenesis.

Male infertility associated with multiple mitochondrial DNA rearrangements.

V. Rohmer, P. Reynier, P. Lestienne, 1997, Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie.

Increased sperm mitochondrial DNA content in male infertility.

P. Reynier, F. Savagner, Y. Malthiéry, 2003, Human reproduction.

Mutations in MTHFR and POLG impaired activity of the mitochondrial respiratory chain in 46-year-old twins with spastic paraparesis

M. Baumgartner, V. Desquiret-Dumas, P. Reynier, 2019, Journal of Human Genetics.

Pro-oxidant effect of ALA is implicated in mitochondrial dysfunction of HepG2 cells.

P. Reynier, H. Puy, C. Schmitt, 2014, Biochimie.

A Metabolomic Profile of Seminal Fluid in Extremely Severe Oligozoopermia Suggesting an Epididymal Involvement

P. Reynier, O. Blanchet, P. May-Panloup, 2022, Metabolites.

Mitochondria: their role in spermatozoa and in male infertility.

P. Reynier, P. May-Panloup, P. Bouet, 2021, Human reproduction update.

Metabolomic Profiling of Aqueous Humor in Glaucoma Points to Taurine and Spermine Deficiency: Findings from the Eye-D Study.

C. Annweiler, D. Milea, P. Gohier, 2019, Journal of proteome research.

Maternal smoking is associated with mitochondrial DNA depletion and respiratory chain complex III deficiency in placenta.

P. Ritz, P. Reynier, G. Simard, 2005, American journal of physiology. Endocrinology and metabolism.

Hepatitis C virus genotypes in chronic hepatitis and response to interferon-alpha therapy.

P. Reynier, P. Halfon, M. Bourlière, 1993, The Journal of infectious diseases.

Secondary coenzyme q deficiency in neurological disorders.

G. Lenaers, P. Reynier, Olivier R Baris, 2021, Free radical biology & medicine.

Biallelic Variants in UBA5 Reveal that Disruption of the UFM1 Cascade Can Result in Early-Onset Encephalopathy.

Thomas Meitinger, Guy Lenaers, Patrizia Amati-Bonneau, 2016, American journal of human genetics.

Comparison of Spheroids Formed by Rat Glioma Stem Cells and Neural Stem Cells Reveals Differences in Glucose Metabolism and Promising Therapeutic Applications*

P. Naveilhan, P. Reynier, V. Bonnamain, 2012, The Journal of Biological Chemistry.

Resveratrol Directly Binds to Mitochondrial Complex I and Increases Oxidative Stress in Brain Mitochondria of Aged Mice

V. Desquiret-Dumas, G. Lenaers, P. Reynier, 2015, PloS one.

Current mechanistic insights into the CCCP‐induced cell survival response

Guy Lenaers, Vincent Procaccio, Pascal Reynier, 2018, Biochemical pharmacology.

Dominant optic atrophy: Culprit mitochondria in the optic nerve

P. Yu-Wai-Man, G. Lenaers, P. Reynier, 2020, Progress in Retinal and Eye Research.

OPA1: 516 unique variants and 831 patients registered in an updated centralized Variome database

Dan Milea, Johan T den Dunnen, Xavier Zanlonghi, 2019, Orphanet journal of rare diseases.

The Metabolomic Bioenergetic Signature of Opa1-Disrupted Mouse Embryonic Fibroblasts Highlights Aspartate Deficiency

D. Bonneau, P. Amati‐Bonneau, G. Lenaers, 2018, Scientific Reports.

Autophagy controls the pathogenicity of OPA1 mutations in dominant optic atrophy

V. Desquiret-Dumas, D. Bonneau, P. Amati‐Bonneau, 2017, Journal of cellular and molecular medicine.

Multiethnic involvement in autosomal-dominant optic atrophy in Singapore

J. Loo, D. Milea, D. Bonneau, 2017, Eye.

Loss of functional OPA1 unbalances redox state: implications in dominant optic atrophy pathogenesis

P. Reynier, A. Galinier, A. Devin, 2016, Annals of clinical and translational neurology.

Mitochondrial dysfunction affecting visual pathways.

D. Milea, D. Bonneau, P. Amati‐Bonneau, 2014, Revue neurologique.

Multi-system neurological disease is common in patients with OPA1 mutations

D. Turnbull, M. Zeviani, A. Wright, 2010, Brain : a journal of neurology.

Genetically determined optic neuropathies.

D. Milea, D. Bonneau, P. Amati‐Bonneau, 2010, Current opinion in neurology.

OPA1-associated disorders: phenotypes and pathophysiology.

D. Milea, D. Bonneau, P. Amati‐Bonneau, 2009, The international journal of biochemistry & cell biology.

OPA1 functions in mitochondria and dysfunctions in optic nerve.

G. Lenaers, P. Reynier, B. Ducommun, 2009, The international journal of biochemistry & cell biology.

Molecular screening of 980 cases of suspected hereditary optic neuropathy with a report on 77 novel OPA1 mutations

D. Milea, D. Bonneau, P. Amati‐Bonneau, 2009, Human mutation.

Acute and late-onset optic atrophy due to a novel OPA1 mutation leading to a mitochondrial coupling defect

A. Toutain, D. Bonneau, P. Amati‐Bonneau, 2009, Molecular vision.

P. Amati‐Bonneau, P. Reynier, Denis Pierron, 2009, BMC Medical Genetics.

OPA1 mutations induce mitochondrial DNA instability and optic atrophy 'plus' phenotypes.

R. Schwarzenbacher, D. Figarella-Branger, C. La Morgia, 2008, Brain : a journal of neurology.

Effects of OPA1 mutations on mitochondrial morphology and apoptosis: Relevance to ADOA pathogenesis

V. Mils, D. Bonneau, P. Amati‐Bonneau, 2007, Journal of cellular physiology.

eOPA1: An online database for OPA1 mutations

P. Amati‐Bonneau, P. Reynier, M. Ferré, 2005, Human mutation.

Sporadic optic atrophy due to synonymous codon change altering mRNA splicing of OPA1

L. Pasquier, D. Bonneau, P. Amati‐Bonneau, 2005, Clinical genetics.

Next generation sequencing in family with MNGIE syndrome associated to optic atrophy: Novel homozygous POLG mutation in the C-terminal sub-domain leading to mtDNA depletion.

C. Bris, D. Goudenège, V. Desquiret-Dumas, 2019, Clinica chimica acta; international journal of clinical chemistry.

mtDNA controls expression of the Death Associated Protein 3.

P. Reynier, F. Savagner, A. Chevrollier, 2006, Experimental cell research.

Adenine nucleotide translocase 2 is a key mitochondrial protein in cancer metabolism.

P. Reynier, A. Chevrollier, D. Loiseau, 2011, Biochimica et biophysica acta.

Is ABCC6 a genuine mitochondrial protein?

G. Leftheriotis, D. Bonneau, P. Reynier, 2013, BMC Research Notes.

Transcriptional profiling reveals coordinated up-regulation of oxidative metabolism genes in thyroid oncocytic tumors.

F. Bertucci, B. Loriod, S. Granjeaud, 2004, The Journal of clinical endocrinology and metabolism.

NR2F1 database: 112 variants and 84 patients support refining the clinical synopsis of Bosch–Boonstra–Schaaf optic atrophy syndrome

J. D. den Dunnen, D. Milea, P. Gohier, 2021, Human mutation.

Structure and chromosomal distribution of human mitochondrial pseudogenes.

Philippe Dessen, Pascal Reynier, P. Dessen, 2002, Genomics.

Isolation and characterization of a repetitive DNA sequence from Leishmania infantum: development of a visceral leishmaniasis polymerase chain reaction.

R. Piarroux, P. Reynier, H. Dumon, 1993, The American journal of tropical medicine and hygiene.

Molecular characterization of corona radiata cells from patients with diminished ovarian reserve using microarray and microfluidic-based gene expression profiling.

Pascal Reynier, P. Reynier, S. Lemerle, 2012, Human reproduction.

Two-step differential expression analysis reveals a new set of genes involved in thyroid oncocytic tumors.

Pascal Reynier, Frédérique Savagner, Serge Guyetant, 2005, The Journal of clinical endocrinology and metabolism.

Improved detection of mitochondrial DNA instability in mitochondrial genome maintenance disorders

M. Martin-Négrier, C. Bris, D. Goudenège, 2021, Genetics in Medicine.

CLUH couples mitochondrial distribution to the energetic and metabolic status

D. Logan, D. Goudenège, V. Desquiret-Dumas, 2017, Journal of Cell Science.

Low oocyte mitochondrial DNA content in ovarian insufficiency.

P. Reynier, Y. Malthiéry, P. May-Panloup, 2005, Human reproduction.

Study of mitochondrial function in placental insufficiency.

V. Desquiret-Dumas, G. Lenaers, P. Reynier, 2018, Placenta.

Rare Primary Mitochondrial DNA Mutations and Probable Synergistic Variants in Leber’s Hereditary Optic Neuropathy

M. Zeviani, C. Orssaud, A. Torroni, 2012, PloS one.

[Mass spectrometry for steroid assays].

D. Guilloteau, P. Reynier, J. Corcuff, 2015, Annales de biologie clinique.

Yeast as a system for modeling mitochondrial disease mechanisms and discovering therapies

L. Steinmetz, Raeka S. Aiyar, A. Glatigny, 2015, Disease Models & Mechanisms.

AK2 deficiency compromises the mitochondrial energy metabolism required for differentiation of human neutrophil and lymphoid lineages

P. Reynier, M. Fontenay, O. Hermine, 2015, Cell Death and Disease.

Metabolomics and Lipidomics Profiling of a Combined Mitochondrial Plus Endoplasmic Reticulum Fraction of Human Fibroblasts: A Robust Tool for Clinical Studies.

G. Lenaers, P. Reynier, C. Bocca, 2018, Journal of proteome research.

Metabo-lipidomics of Fibroblasts and Mitochondrial-Endoplasmic Reticulum Extracts from ALS Patients Shows Alterations in Purine, Pyrimidine, Energetic, and Phospholipid Metabolisms

C. Bris, G. Lenaers, P. Reynier, 2019, Molecular Neurobiology.

Low serum testosterone assayed by liquid chromatography-tandem mass spectrometry. Comparison with five immunoassay techniques.

P. Reynier, Y. Malthiéry, Y. Gallois, 2007, Clinica chimica acta; international journal of clinical chemistry.

No Evidence of Thyrotropin Receptor and GSα Gene Mutation in High Iodine Uptake Thyroid Carcinoma

M. Duquenne, V. Rohmer, P. Reynier, 2000 .

The mitochondrial DNA content of cumulus cells may help predict embryo implantation

V. Desquiret-Dumas, P. Reynier, V. Procaccio, 2018, Journal of Assisted Reproduction and Genetics.

Reproductive biology Themitochondrial DNA content of cumulus granulosa cells is linked to embryo quality

V. Desquiret-Dumas, P. Reynier, V. Procaccio, 2017 .

A mitochondria-specific isoform of FASTK is present in mitochondrial RNA granules and regulates gene expression and function.

Alexis A. Jourdain, P. Anderson, J. Martinou, 2015, Cell reports.

AMitochondria-Specific Is oformof FASTK Is Present In Mitochondrial RNA Granules and Regulates Gene Expression and Function Graphical

Alexis A. Jourdain, P. Anderson, J. Martinou, 2015 .

DMM020438 509..526

L. Steinmetz, Raeka S. Aiyar, A. Glatigny, 2015 .

Accumulation of deletions in MtDNA during tissue aging: analysis by long PCR.

P. Reynier, Y. Malthiéry, 1995, Biochemical and biophysical research communications.

Diagnosis of myotubular myopathy in the oldest known manifesting female carrier: A clinical and genetic study

M. Cossée, P. Reynier, V. Biancalana, 2007, Neuromuscular Disorders.

Mitochondrial energetic defects in muscle and brain of a Hmbs-/- mouse model of acute intermittent porphyria.

V. Desquiret-Dumas, P. Reynier, J. Deybach, 2015, Human molecular genetics.

Cloning and initial characterization of human and mouse Spot 14 genes 1

P. Reynier, A. Dace, H. Khiri, 1997, FEBS letters.

Long-Term Persistence of Mitochondrial DNA Instability in HIV-Exposed Uninfected Children during and after Exposure to Antiretroviral Drugs and HIV

J. Molès, C. Bris, D. Goudenège, 2022, Biomedicines.

Mitochondrial DNA Analysis

P. Reynier, P. Lestienne, Y. Malthiéry, 1999 .

Sexual Dimorphism of Metabolomic Profile in Arterial Hypertension

M. Diakité, P. Reynier, G. Simard, 2020, Scientific Reports.

Increase of mitochondrial DNA content and transcripts in early bovine embryogenesis associated with upregulation of mtTFA and NRF1 transcription factors

P. Reynier, Y. Heyman, X. Vignon, 2005, Reproductive biology and endocrinology : RB&E.

The Long Non-Coding RNA SAMMSON Is a Regulator of Chemosensitivity and Metabolic Orientation in MCF-7 Doxorubicin-Resistant Breast Cancer Cells

V. Desquiret-Dumas, G. Lenaers, P. Reynier, 2021, Biology.

West syndrome and mitochondrial diabetes: relationship or coincidence?

P. Reynier, B. Bouhanick, R. Coutant, 2002, Clinical endocrinology.

A Tear Metabolomic Profile Showing Increased Ornithine Decarboxylase Activity and Spermine Synthesis in Thyroid-Associated Orbitopathy

P. Gohier, P. Reynier, M. Ferré, 2022, Journal of clinical medicine.

New evidence of a mitochondrial genetic background paradox: Impact of the J haplogroup on the A3243G mutation

M. Crouzet, M. Martin-Négrier, P. Reynier, 2008, BMC Medical Genetics.

Decreased expression of thyrotropin receptor gene suggests a high-risk subgroup for oncocytic adenoma.

V. Rohmer, P. Reynier, B. Franc, 2004, European journal of endocrinology.

Mutations in aARS genes revealed by targeted next-generation sequencing in patients with mitochondrial diseases

C. Bris, D. Goudenège, V. Desquiret-Dumas, 2020, Molecular Biology Reports.

Endometriosis Lowers the Cumulative Live Birth Rates in IVF by Decreasing the Number of Embryos but Not Their Quality

P. Reynier, P. Descamps, P. May-Panloup, 2020, Journal of clinical medicine.

A common variant near TGFBR3 is associated with primary open angle glaucoma

S. R. Krishnadas, J. Haines, Y. Teo, 2015, Human molecular genetics.

Relative Frequencies of Inherited Retinal Dystrophies and Optic Neuropathies in Southern France: Assessment of 21-year Data Management

J. Sahel, P. Calvas, M. Claustres, 2013, Ophthalmic epidemiology.

Mitochondrial macro-haplogroup JT may play a protective role in ovarian ageing.

P. Reynier, V. Procaccio, S. Lemerle, 2014, Mitochondrion.

mtDNA haplogroup J: a contributing factor of optic neuritis

P. Reynier, F. Savagner, F. Dubas, 1999, European Journal of Human Genetics.

Oxidative stress contributes differentially to the pathophysiology of Charcot-Marie-Tooth disease type 2K

D. Bonneau, G. Lenaers, P. Reynier, 2020, Experimental Neurology.

Obesity-induced metabolic disturbance drives oxidative stress and complement activation in the retinal environment

J. Provis, P. Reynier, K. Valter, 2018, Molecular vision.

Cataract as a Phenotypic Marker for a Mutation in WFS1, the Wolfram Syndrome Gene

G. Rondouin, P. Amati‐Bonneau, G. Lenaers, 2012, European journal of ophthalmology.

5-Oxoprolinuria in hyperammonemic encephalopathy: Coincidence or worsening factor?

P. Reynier, G. Simard, G. Rousseau, 2017, Clinical biochemistry.

Oligoasthenospermia associated with multiple mitochondrial DNA rearrangements.

V. Rohmer, P. Reynier, P. Lestienne, 1997, Molecular human reproduction.

In Vitro Embryo Production Efficiency in Cattle and Its Association with Oocyte Adenosine Triphosphate Content, Quantity of Mitochondrial DNA, and Mitochondrial DNA Haplogroup

S. Hiendleder, M. Stojkovic, P. Reynier, 2004, Biology of reproduction.

Defective mitochondrial ATP synthesis in oxyphilic thyroid tumors.

P. Reynier, B. Franc, F. Savagner, 2001, The Journal of clinical endocrinology and metabolism.

ACO2 clinicobiological dataset with extensive phenotype ontology annotation

J. D. den Dunnen, D. Milea, P. Gohier, 2021, Scientific data.

A Metabolomic Profiling of Intra-Uterine Growth Restriction in Placenta and Cord Blood Points to an Impairment of Lipid and Energetic Metabolism

P. Reynier, G. Gascoin, G. Simard, 2022, Biomedicines.

Retinal metabolic events in preconditioning light stress as revealed by wide-spectrum targeted metabolomics

P. Reynier, K. Valter, G. Simard, 2017, Metabolomics.

Hereditary spastic paraplegia-like disorder due to a mitochondrial ATP6 gene point mutation.

D. Bonneau, P. Amati‐Bonneau, P. Reynier, 2011, Mitochondrion.

Neurotoxicity of Insecticides.

G. Lenaers, P. Reynier, V. Procaccio, 2017, Current medicinal chemistry.

A Metabolomics Profiling of Glaucoma Points to Mitochondrial Dysfunction, Senescence, and Polyamines Deficiency.

D. Milea, P. Gohier, D. Bonneau, 2018, Investigative Ophthalmology and Visual Science.

Optic neuropathy linked to ACAD9 pathogenic variants: a potentially riboflavin-responsive disorder?

M. Koenig, G. Lenaers, P. Reynier, 2021, Mitochondrion.

Novel NDUFS4 gene mutation in an atypical late-onset mitochondrial form of multifocal dystonia

C. Bris, D. Goudenège, V. Desquiret-Dumas, 2017, Neurology: Genetics.

The addition of ketone bodies alleviates mitochondrial dysfunction by restoring complex I assembly in a MELAS cellular model.

Daniel Henrion, Guy Lenaers, Patrizia Amati-Bonneau, 2017, Biochimica et biophysica acta. Molecular basis of disease.

NOVEL NDUFS 4 GENE MUTATION IN AN ATYPICAL LATE-ONSET MITOCHONDRIAL FORM OF MULTIFOCAL DYSTONIA Mitochondrial

D. Goudenège, V. Desquiret-Dumas, D. Bonneau, 2022 .

Mitochondrial Dysfunction in Mitochondrial Medicine: Current Limitations, Pitfalls, and Tomorrow.

G. Lenaers, P. Reynier, V. Weissig, 2021, Methods in molecular biology.

A serum metabolomics signature of hypothermia fatalities involving arginase activity, tryptophan content, and phosphatidylcholine saturation

P. Reynier, C. Palmiere, G. Simard, 2018, International Journal of Legal Medicine.

Resveratrol Induces a Mitochondrial Complex I-dependent Increase in NADH Oxidation Responsible for Sirtuin Activation in Liver Cells*

V. Desquiret-Dumas, D. Bonneau, P. Reynier, 2013, The Journal of Biological Chemistry.

Dominant ACO2 mutations are a frequent cause of isolated optic atrophy

M. Carbonelli, P. Gohier, P. Yu-Wai-Man, 2021, Brain communications.

Familial Dysalbuminemic Hyperthyroxinemia: An Underdiagnosed Entity

P. Reynier, V. Moal, P. Rodien, 2020, Journal of clinical medicine.

Increased Protein S-Glutathionylation in Leber’s Hereditary Optic Neuropathy (LHON)

D. Milea, C. Verma, R. Beuerman, 2020, International journal of molecular sciences.

Ocular growth and metabolomics are dependent upon the spectral content of ambient white light

D. Milea, R. Najjar, P. Reynier, 2021, Scientific Reports.

Acetoacetate protects macrophages from lactic acidosis-induced mitochondrial dysfunction by metabolic reprograming

P. Reynier, V. Procaccio, F. Manero, 2021, Nature Communications.

Lipidomics Reveals Cerebrospinal-Fluid Signatures of ALS

G. Lenaers, P. Reynier, P. Vourc'h, 2017, Scientific Reports.

Apparent resistance to thyroid hormones: From biological interference to genetics.

P. Reynier, V. Moal, P. Rodien, 2019, Annales d'endocrinologie.

Metabolomic Profiling of Plasma and Erythrocytes in Sickle Mice Points to Altered Nociceptive Pathways

P. Reynier, D. Henrion, C. Veyrat-Durebex, 2020, Cells.

Cyclosporine A does not prevent second-eye involvement in Leber’s hereditary optic neuropathy

C. Tilikete, C. Orssaud, D. Milea, 2018, Orphanet Journal of Rare Diseases.

Elevated Levels of Monocyte Chemotactic Protein-1 in the Follicular Fluid Reveals Different Populations among Women with Severe Endometriosis

P. Reynier, P. Descamps, P. May-Panloup, 2020, Journal of clinical medicine.

Metabolomics shows no impairment of the microenvironment of the cumulus-oocyte complex in women with isolated endometriosis.

P. Reynier, P. Descamps, P. May-Panloup, 2019, Reproductive biomedicine online.

Physiology of PNS axons relies on glycolic metabolism in myelinating Schwann cells

G. Lenaers, P. Reynier, J. Devaux, 2020, bioRxiv.

[Mitochondria and reproduction].

P. Reynier, Y. Malthiéry, P. May-Panloup, 2004, Medecine sciences : M/S.

Mitochondrial complex I defect resulting from exercise-induced lower limb ischemia in patients with peripheral arterial disease.

P. Abraham, C. Baufreton, P. Reynier, 2018, Journal of applied physiology.

Clinical Heterogeneity of Hereditary Optic Atrophy in a Turkish Family

P. Amati‐Bonneau, P. Reynier, Y. Alanay, 2005 .

Deep sequencing shows that oocytes are not prone to accumulate mtDNA heteroplasmic mutations during ovarian ageing

C. Bris, D. Goudenège, V. Desquiret-Dumas, 2017, Human reproduction.

Gene profiling reveals specific oncogenic mechanisms and signaling pathways in oncocytic and papillary thyroid carcinoma

B. Loriod, S. Granjeaud, R. Houlgatte, 2005, Oncogene.

Long PCR analysis of human gamete mtDNA suggests defective mitochondrial maintenance in spermatozoa and supports the bottleneck theory for oocytes.

V. Rohmer, P. Reynier, P. Barrière, 1998, Biochemical and biophysical research communications.

Increased steroidogenesis promotes early-onset and severe vision loss in females with OPA1 dominant optic atrophy.

M. Larsen, D. Milea, G. Lenaers, 2017, Human molecular genetics.

Oxygen consumption and expression of the adenine nucleotide translocator in cells lacking mitochondrial DNA.

P. Reynier, A. Chevrollier, Y. Malthiéry, 2002, Experimental cell research.

NR2F1 database: 112 variants and 84 patients support refining the clinical synopsis of Bosch–Boonstra–Schaaf optic atrophy syndrome

J. D. den Dunnen, D. Milea, P. Gohier, 2021, Human mutation.

Loss of function of Ywhah in mice induces deafness and cochlear outer hair cells' degeneration

G. Rebillard, B. Delprat, P. Chinnery, 2016, Cell Death Discovery.

Myelinating Schwann cells use Warburg effect to sustain axonal physiology and function

G. Lenaers, P. Reynier, J. Devaux, 2020 .

One Sentence Summary : Lactate-dependent axons rely on Warburg effect in Schwann cells

G. Lenaers, P. Reynier, J. Devaux, 2020 .

Dominant mutations in MIEF1 affect mitochondrial dynamics and cause a singular late onset optic neuropathy

D. Krainc, D. Bonneau, P. Amati‐Bonneau, 2021, Molecular neurodegeneration.

The Metabolomic Signature of Opa1 Deficiency in Rat Primary Cortical Neurons Shows Aspartate/Glutamate Depletion and Phospholipids Remodeling

G. Lenaers, P. Reynier, C. Bocca, 2019, Scientific Reports.

A conserved N-terminal sequence targets human DAP3 to mitochondria.

P. Reynier, F. Savagner, Y. Tourmen, 2001, Biochemical and biophysical research communications.

Comparison of spinal magnetic resonance imaging and classical clinical factors in predicting motor capacity in amyotrophic lateral sclerosis

Jeanne M. Miller, K. Dujardin, V. Marchand-Pauvert, 2023, Journal of Neurology.

[An OPA3 gene mutation is responsible for the disease associating optic atrophy and cataract with extrapyramidal signs].

D. Bonneau, P. Amati‐Bonneau, P. Reynier, 2005, Revue neurologique.

A novel mutation in the mitochondrial tRNA Asn gene associated with a lethal disease.

F. Chapon, P. Reynier, S. Allouche, 2005, Biochemical and biophysical research communications.

Ocular growth and metabolomics are dependent upon the spectral content of white light

D. Milea, R. Najjar, P. Reynier, 2018 .

Are zona pellucida genes involved in recurrent oocyte lysis observed during in vitro fertilization?

P. Amati‐Bonneau, P. Reynier, V. Procaccio, 2014, Journal of Assisted Reproduction and Genetics.

An immuno-lipidomic signature revealed by metabolomic and machine-learning approaches in labial salivary gland to diagnose primary Sjögren’s syndrome

P. Reynier, B. Davidson, G. Simard, 2023, Frontiers in immunology.

Combined Metabolipidomic and Machine Learning Approach in a Rat Model of Stroke Reveals a Deleterious Impact of Brain Injury on Heart Metabolism

P. Reynier, F. Prunier, D. Mirebeau-Prunier, 2023, International journal of molecular sciences.

A locus-specific database for mutations in GDAP1 allows analysis of genotype-phenotype correlations in Charcot-Marie-Tooth diseases type 4A and 2K

D. Bonneau, P. Reynier, V. Procaccio, 2011, Orphanet journal of rare diseases.

Quantitative multistandard RT-PCR assay using interspecies polymorphism.

P. Reynier, H. Khiri, R. Planells, 1996, Molecular and cellular probes.

DMM020438 509..526

L. Steinmetz, Raeka S. Aiyar, A. Glatigny, 2015 .

P. Amati‐Bonneau, P. Reynier, C. Rocher, 2009, BMC Medical Genetics.

A Metabolomics Profiling of Glaucoma Points to Mitochondrial Dysfunction, Senescence, and Polyamines Deficiency.

D. Milea, P. Gohier, D. Bonneau, 2018, Investigative ophthalmology & visual science.

Autophagy protein 5 controls flow-dependent endothelial functions

X. Guillonneau, P. Reynier, T. Couffinhal, 2023, Cellular and Molecular Life Sciences.

Reply: The expanding neurological phenotype of DNM1L-related disorders.

N. Boddaert, D. Bonneau, P. Amati‐Bonneau, 2018, Brain : a journal of neurology.

The addition of ketone bodies alleviates mitochondrial dysfunction by restoring complex I assembly in a MELAS cellular model.

C. Bris, V. Desquiret-Dumas, D. Bonneau, 2017, Biochimica et biophysica acta. Molecular basis of disease.

OPA3 gene mutations responsible for autosomal dominant optic atrophy and cataract

P. Calvas, D. Bonneau, P. Amati‐Bonneau, 2004, Journal of Medical Genetics.

The human OPA1delTTAG mutation induces premature age-related systemic neurodegeneration in mouse.

N. Boddaert, J. Renou, Jing Wang, 2012, Brain : a journal of neurology.

Targeted Metabolomics Reveals Early Dominant Optic Atrophy Signature in Optic Nerves of Opa1delTTAG/+ Mice.

D. Milea, V. Desquiret-Dumas, D. Bonneau, 2017, Investigative ophthalmology & visual science.

Bioenergetic defect associated with mKATP channel opening in a mouse model carrying a mitofusin 2 mutation

J. Martinou, D. Bonneau, P. Amati‐Bonneau, 2011, The FASEB Journal.

A Nontargeted UHPLC-HRMS Metabolomics Pipeline for Metabolite Identification: Application to Cardiac Remote Ischemic Preconditioning.

D. Bonneau, G. Lenaers, P. Reynier, 2017, Analytical chemistry.

Mitochondrial diseases preferentially involve proteins with prokaryote homologues.

P. Dessen, P. Reynier, M. Ferré, 2004, Comptes rendus biologies.

Case report: Diagnosis of ADCY5-related dyskinesia explaining the entire phenotype in a patient with atypical citrullinemia type I

P. Reynier, C. Homedan, D. Mirebeau-Prunier, 2023, Frontiers in neurology.

Sensorineural hearing loss in OPA1-linked disorders

D. Milea, D. Bonneau, G. Lenaers, 2013 .

Reproductive Biology and Endocrinology Increase of Mitochondrial Dna Content and Transcripts in Early Bovine Embryogenesis Associated with Upregulation of Mttfa and Nrf1 Transcription Factors

P. Reynier, Y. Heyman, X. Vignon, 2022 .

Physiology of PNS axons relies on glycolytic metabolism in myelinating Schwann cells

G. Lenaers, P. Reynier, R. Chrast, 2022, PloS one.

A locus-specific database for mutations in GDAP1 allows analysis of genotype-phenotype correlations in Charcot-Marie-Tooth diseases type 4A and 2K

D. Bonneau, P. Reynier, V. Procaccio, 2011, Orphanet journal of rare diseases.

Liquid chromatography-tandem mass spectrometry for monitoring vitamin D hydroxymetabolites in human aqueous humor

C. Annweiler, D. Milea, P. Reynier, 2019, Analytical Methods.

Ethambutol-induced optic neuropathy linked to OPA1 mutation and mitochondrial toxicity.

D. Bonneau, P. Amati‐Bonneau, P. Reynier, 2010, Mitochondrion.

Tear metabolomics highlights new potential biomarkers for differentiating between Sjögren's syndrome and other causes of dry eye.

P. Gohier, G. Lenaers, P. Reynier, 2021, The ocular surface.

Heterozygous OPA1 mutations in Behr syndrome.

A. Durr, A. Brice, G. Stevanin, 2011, Brain : a journal of neurology.

Achieving Expert-Level Interpretation of Serum Protein Electrophoresis through Deep Learning Driven by Human Reasoning.

P. Reynier, M. Ferré, D. Mirebeau-Prunier, 2021, Clinical chemistry.

Letter to the editor on: prophylactic nicotinamide treatment protects from rotenone-induced neurodegeneration by increasing mitochondrial content and volume

P. Gohier, P. Reynier, C. Verny, 2024, Acta neuropathologica communications.