X. Varelas

发表

Systematic morphological profiling of human gene and allele function via Cell Painting

Anne E Carpenter, Mark-Anthony Bray, Mohammad Hossein Rohban, 2017, eLife.

Systematic morphological profiling of human gene and allele function reveals Hippo-NF-κB pathway connectivity

Anne E Carpenter, Y. Shrestha, J. Boehm, 2016, bioRxiv.

Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2

B. Blencowe, A. Emili, S. Wuchty, 2020, Molecular Cell.

Yap suppresses T-cell function and infiltration in the tumor microenvironment

S. Monti, X. Varelas, Eleni Stampouloglou, 2019, bioRxiv.

A YAP/TAZ-Regulated Molecular Signature Is Associated with Oral Squamous Cell Carcinoma

Stefano Monti, Vinay K. Kartha, Xaralabos Varelas, 2015, Molecular Cancer Research.

The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway.

Janet Rossant, Xaralabos Varelas, Payman Samavarchi-Tehrani, 2010, Developmental cell.

Cdc34 Self-Association Is Facilitated by Ubiquitin Thiolester Formation and Is Required for Its Catalytic Activity

Michael J. Ellison, Xaralabos Varelas, C. Ptak, 2003, Molecular and Cellular Biology.

An Allosteric Inhibitor of the Human Cdc34 Ubiquitin-Conjugating Enzyme

Mike Tyers, Xiaojing Tang, Abdallah Al-Hakim, 2011, Cell.

ZNF416 is a pivotal transcriptional regulator of fibroblast mechano-activation

X. Varelas, G. Ligresti, N. Caporarello, 2020, bioRxiv.

Inactivation of the Hippo tumor suppressor pathway promotes melanoma

Joshua D. Campbell, Neil J Ganem, C. Ceol, 2021, Nature Communications.

TGFβ-induced fibroblast activation requires persistent and targeted HDAC-mediated gene repression

X. Varelas, G. Ligresti, N. Caporarello, 2019, Journal of Cell Science.

Switch enhancers interpret TGF-β and Hippo signaling to control cell fate in human embryonic stem cells.

J. Wrana, T. A. Beyer, X. Varelas, 2013, Cell reports.

Arterial stiffness induces remodeling phenotypes in pulmonary artery smooth muscle cells via YAP/TAZ-mediated repression of cyclooxygenase-2.

X. Varelas, K. M. Choi, D. Tschumperlin, 2017, American journal of physiology. Lung cellular and molecular physiology.

Virtual screening for small molecule pathway regulators by image profile matching

Anne E Carpenter, Ashley M. Fuller, R. Derynck, 2021, bioRxiv.

TAZ Forces Lateral Inhibition.

X. Varelas, Joseph G. Kern, 2019, Developmental cell.

Phosphatidic Acid Signals via the Hippo Pathway.

X. Varelas, Eleni Stampouloglou, 2018, Molecular cell.

Integrin‐FAK‐CDC42‐PP1A signaling gnaws at YAP/TAZ activity to control incisor stem cells

X. Varelas, Julia Hicks-Berthet, 2017, BioEssays : news and reviews in molecular, cellular and developmental biology.

The hippo pathway effector Yap controls patterning and differentiation of airway epithelial progenitors.

X. Varelas, W. Cardoso, Munemasa Mori, 2014, Developmental cell.

Distinct polarity cues direct Taz/Yap and TGFβ receptor localization to differentially control TGFβ-induced Smad signaling.

J. Wrana, X. Varelas, P. Samavarchi-Tehrani, 2015, Developmental cell.

Lung Atelectasis Promotes Immune and Barrier Dysfunction as Revealed by Transcriptome Sequencing in Female Sheep

K. Grogg, X. Varelas, L. Sholl, 2020, Anesthesiology.

Purification and properties of the ubiquitin-conjugating enzymes Cdc34 and Ubc13.Mms2.

C. Ptak, X. Varelas, S. McKenna, 2005, Methods in enzymology.

Title: Virtual screening for small molecule pathway regulators by image profile matching of hits modulating the p38ɑ Discovery of hits impacting PPARGC1A (PGC-1α) overexpression phenotypes

Anne E Carpenter, Ashley M. Fuller, R. Derynck, 2021 .

Basal extrusion of single‐oncogenic mutant cells induces dome‐like structures with altered microenvironments

X. Varelas, Yasuyuki Fujita, Andrew Tilston-Lunel, 2022, Cancer science.

Inactivation of LATS1/2 drives luminal-basal plasticity to initiate basal-like mammary carcinomas

S. Monti, M. Lenburg, J. Beane, 2022, Nature Communications.

Inhibition of LSD1 epigenetically attenuates oral cancer growth and metastasis

Vinay K. Kartha, S. Monti, X. Varelas, 2017, Oncotarget.

Gene expression alterations in salivary gland epithelia of Sjögren’s syndrome patients are associated with clinical and histopathological manifestations

Vinay K. Kartha, S. Monti, M. Mingueneau, 2021, Scientific Reports.

The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease

Xaralabos Varelas, X. Varelas, 2014, Development.

TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal

M. Yaffe, J. Wrana, P. Zandstra, 2008, Nature Cell Biology.

Yap suppresses T-cell function and infiltration in the tumor microenvironment

S. Monti, X. Varelas, Eleni Stampouloglou, 2020, PLoS biology.

Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis

A. Letai, M. Baron, J. Montero, 2017, Science Translational Medicine.

The Hippo signaling pathway is required for salivary gland development and its dysregulation is associated with Sjogren's-like disease

X. Varelas, D. Faustman, K. Skarstein, 2013, Laboratory Investigation.

Targeting the Hippo pathway in cancer, fibrosis, wound healing and regenerative medicine

K. Guan, X. Varelas, A. Dey, 2020, Nature Reviews Drug Discovery.

Biogenesis through Let-7 Regulate Dicer Expression and MicroRNA The Hippo Pathway Effectors TAZ/YAP Reports:

X. Varelas, S. Chaulk, R. Fahlman, 2014 .

The Hippo Pathway Effectors TAZ/YAP Regulate Dicer Expression and MicroRNA Biogenesis through Let-7

X. Varelas, S. Chaulk, R. Fahlman, 2013, The Journal of Biological Chemistry.

Expression of Piwi protein MIWI2 defines a distinct population of multiciliated cells.

D. O’Carroll, Matthew R. Jones, X. Varelas, 2017, The Journal of clinical investigation.

Crumbs3-Mediated Polarity Directs Airway Epithelial Cell Fate through the Hippo Pathway Effector Yap.

X. Varelas, W. Cardoso, Aleksander D. Szymaniak, 2015, Developmental cell.

Altered RNA editing in 3′ UTR perturbs microRNA-mediated regulation of oncogenes and tumor-suppressors

Stefano Monti, Xaralabos Varelas, S. Monti, 2016, Scientific Reports.

Glutamine‐utilizing transaminases are a metabolic vulnerability of TAZ/YAP‐activated cancer cells

S. Monti, X. Varelas, Liye Zhang, 2018, EMBO reports.

Therapeutic Targeting of TAZ and YAP by Dimethyl Fumarate in Systemic Sclerosis Fibrosis.

Brendon M. Baker, B. Baker, R. Simms, 2018, The Journal of investigative dermatology.

CALL FOR PAPERS Translational Research in Acute Lung Injury and Pulmonary Fibrosis Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis

Lauren E. Stopfer, X. Varelas, D. Tschumperlin, 2015 .

Integrating developmental signals: a Hippo in the (path)way

X. Varelas, A. Mauviel, F. Nallet-staub, 2012, Oncogene.

The Hippo pathway regulates Wnt/beta-catenin signaling.

Frederic A. Fellouse, T. Pawson, J. Wrana, 2010, Developmental cell.

Obesity-induced senescent macrophages activate a fibrotic transcriptional program in adipocyte progenitors

X. Varelas, S. Farmer, M. Layne, 2022, Life Science Alliance.

Coordinating developmental signaling: novel roles for the Hippo pathway.

J. Wrana, X. Varelas, 2012, Trends in cell biology.

Protein N-glycosylation in oral cancer: Dysregulated cellular networks among DPAGT1, E-cadherin adhesion and canonical Wnt signaling

X. Varelas, M. Kukuruzinska, Meghan P. Bouchie, 2014, Glycobiology.

Notch3-Jagged signaling controls the pool of undifferentiated airway progenitors

Hong Zhang, X. Varelas, W. Cardoso, 2015, Development.

DEV116855 258..267

Hong Zhang, X. Varelas, W. Cardoso, 2014 .

Yap/Taz inhibit goblet cell fate to maintain lung epithelial homeostasis

S. Monti, M. Lenburg, J. Beane, 2021, Cell reports.

Aberrant epithelial polarity cues drive the development of precancerous airway lesions

A. Spira, J. Beane, X. Varelas, 2021, Proceedings of the National Academy of Sciences.

Phosphorylation of the Tumor Suppressor Fat Is Regulated by Its Ligand Dachsous and the Kinase Discs Overgrown

J. Wrana, Richelle Sopko, S. Blair, 2009, Current Biology.

N-Glycosylation Induces the CTHRC1 Protein and Drives Oral Cancer Cell Migration*

X. Varelas, V. Lindner, M. Kukuruzinska, 2013, The Journal of Biological Chemistry.

TAZ activation drives fibroblast spheroid growth, expression of profibrotic paracrine signals, and context-dependent ECM gene expression.

X. Varelas, D. Tschumperlin, Delphine Sicard, 2017, American journal of physiology. Cell physiology.

Stem cell regulation by the Hippo pathway.

X. Varelas, S. Hiemer, 2013, Biochimica et biophysica acta.

Non-canonical Roles for the Hippo Pathway

X. Varelas, 2013 .

The Transcriptional Regulators TAZ and YAP Direct Transforming Growth Factor β-induced Tumorigenic Phenotypes in Breast Cancer Cells*♦

Xaralabos Varelas, X. Varelas, S. Hiemer, 2014, The Journal of Biological Chemistry.

Hsp70–Bag3 complex is a hub for proteotoxicity-induced signaling that controls protein aggregation

A. Narayanan, X. Varelas, M. Sherman, 2018, Proceedings of the National Academy of Sciences.

Head and neck cancer: from research to therapy and cure

X. Varelas, M. Kukuruzinska, 2014, Annals of the New York Academy of Sciences.

ZNF416 is a pivotal transcriptional regulator of fibroblast mechanoactivation

X. Varelas, G. Ligresti, N. Caporarello, 2021, The Journal of cell biology.

Generation of human alveolar epithelial type I cells from pluripotent stem cells

E. Morrisey, X. Varelas, D. Kotton, 2022, bioRxiv.

Identification of candidate cancer drivers by integrative Epi-DNA and Gene Expression (iEDGE) data analysis

P. Sebastiani, S. Monti, X. Varelas, 2019, Scientific Reports.

Loss of G-Protein Pathway Suppressor 2 Promotes Tumor Growth Through Activation of AKT Signaling

A. Emili, S. Monti, X. Varelas, 2021, Frontiers in Cell and Developmental Biology.

The in vivo genetic program of murine primordial lung epithelial progenitors

Ignacio S. Caballero, E. Kolaczyk, E. Morrisey, 2020, Nature Communications.

Functional and genomic analyses reveal therapeutic potential of targeting β-catenin/CBP activity in head and neck cancer

Vinay K. Kartha, S. Monti, A. Egloff, 2018, Genome Medicine.

The Tumor Suppressor CYLD Inhibits Mammary Epithelial to Mesenchymal Transition by the Coordinated Inhibition of YAP/TAZ and TGFβ Signaling

C. Ainali, D. Dafou, X. Varelas, 2020, Cancers.

Targeting the Hippo pathway in cancer, fibrosis, wound healing and regenerative medicine

K. Guan, X. Varelas, A. Dey, 2020, Nature Reviews Drug Discovery.

Naturally occurring hotspot cancer mutations in Gα13 promote oncogenic signaling

S. Monti, X. Varelas, Jingyi Zhao, 2020, The Journal of Biological Chemistry.

Selective YAP/TAZ inhibition in fibroblasts via dopamine receptor D1 agonism reverses fibrosis

V. Shah, X. Varelas, C. Pabelick, 2019, Science Translational Medicine.

The Ubiquitin Binding Region of the Smurf HECT Domain Facilitates Polyubiquitylation and Binding of Ubiquitylated Substrates*

J. Wrana, F. Sicheri, J. Forman-Kay, 2009, The Journal of Biological Chemistry.

The Cdc34/SCF Ubiquitination Complex Mediates Saccharomyces cerevisiae Cell Wall Integrity

C. Ptak, D. Stuart, X. Varelas, 2006, Genetics.

Single Cell Transcriptomics of Fibrotic Lungs Unveils Aging-associated Alterations in Endothelial and Epithelial Cell Regeneration

U. V. von Andrian, X. Varelas, G. Ligresti, 2023, bioRxiv.

CaDrA: A Computational Framework for Performing Candidate Driver Analyses Using Genomic Features

Liye Zhang, Paola Sebastiani, Stefano Monti, 2019, Front. Genet..

CaDrA: A computational framework for performing candidate driver analyses using binary genomic features

Liye Zhang, Stefano Monti, Paola Sebastiani, 2017, bioRxiv.

iEDGE: integration of Epi-DNA and Gene Expression and applications to the discovery of somatic copy number-associated drivers in cancer

P. Sebastiani, S. Monti, X. Varelas, 2019, bioRxiv.

Immunofluorescence Microscopy to Study Endogenous TAZ in Mammalian Cells.

X. Varelas, N. Kingston, Julia Hicks-Berthet, 2018, Methods in molecular biology.

Epithelial LIF signaling limits apoptosis and lung injury during bacterial pneumonia.

X. Varelas, D. Kotton, L. Quinton, 2022, American journal of physiology. Lung cellular and molecular physiology.

Convergence of YAP/TAZ, TEAD and TP63 activity is associated with bronchial premalignant severity and progression

M. Lenburg, A. Spira, J. Beane, 2023, Journal of Experimental & Clinical Cancer Research.

Title: Virtual screening for small molecule pathway regulators by image profile matching of hits modulating the p38ɑ Discovery of hits impacting PPARGC1A (PGC-1α) overexpression phenotypes

Anne E Carpenter, Ashley M. Fuller, Shantanu Singh, 2021 .

β-catenin/CBP activation of mTORC1 signaling promotes partial epithelial-mesenchymal states in head and neck cancer.

Eric R. Reed, S. Monti, X. Varelas, 2023, Translational research : the journal of laboratory and clinical medicine.

Inhibition of LSD1 attenuates oral cancer development and promotes therapeutic efficacy of immune checkpoint blockade and Yap/Taz inhibition.

S. Monti, Prof Vikas Kumar, X. Varelas, 2022, Molecular cancer research : MCR.

Inhibition of LSD1 epigenetically attenuates oral cancer growth and metastasis

Vinay K. Kartha, S. Monti, X. Varelas, 2017, Oncotarget.

Inhibition of LSD 1 epigenetically attenuates oral cancer growth and metastasis

Vinay K. Kartha, S. Monti, X. Varelas, 2017 .

The Hippo pathway effector YAP is an essential regulator of ductal progenitor patterning in the mouse submandibular gland

M. Mingueneau, X. Varelas, T. Reynolds, 2017, eLife.

Structure learning for gene regulatory networks

S. Monti, X. Varelas, Anthony Federico, 2023, PLoS Comput. Biol..

Structure Learning for Hierarchical Regulatory Networks

S. Monti, X. Varelas, Anthony Federico, 2021, bioRxiv.

Total RNA sequencing reveals gene expression and microbial alterations shared by oral pre-malignant lesions and cancer

Mohammed Muzamil Khan, S. Monti, X. Varelas, 2023, bioRxiv.

Patient-specific iPSCs carrying an SFTPC mutation reveal the intrinsic alveolar epithelial dysfunction at the inception of interstitial lung disease

A. Emili, A. Petcherski, S. Russo, 2020, bioRxiv.

A YAP/TAZ-Regulated Molecular Signature Is Associated with Oral Squamous Cell Carcinoma

Vinay K. Kartha, S. Monti, X. Varelas, 2015, Molecular Cancer Research.

Arterial stiffness induces remodeling phenotypes in pulmonary artery smooth muscle cells via YAP/TAZ-mediated repression of cyclooxygenase-2.

X. Varelas, D. Tschumperlin, L. Fredenburgh, 2017, American Journal of Physiology - Lung cellular and Molecular Physiology.

The Hippo pathway regulates Wnt/beta-catenin signaling.

Frederic A. Fellouse, T. Pawson, J. Wrana, 2010, Developmental cell.

CALL FOR PAPERS Translational Research in Acute Lung Injury and Pulmonary Fibrosis Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis

Lauren E. Stopfer, X. Varelas, D. Tschumperlin, 2015 .

Functional and genomic analyses reveal therapeutic potential of targeting β-catenin/CBP activity in head and neck cancer

Vinay K. Kartha, S. Monti, A. Egloff, 2018, Genome Medicine.

Airway stem cell reconstitution by the transplantation of primary or pluripotent stem cell-derived basal cells

S. Randell, X. Varelas, D. Kotton, 2023, Cell stem cell.

Phosphatidic Acid Signals via the Hippo Pathway.

X. Varelas, Eleni Stampouloglou, 2018, Molecular cell.

The Hippo Pathway Effectors TAZ/YAP Regulate Dicer Expression and MicroRNA Biogenesis through Let-7

X. Varelas, S. Chaulk, R. Fahlman, 2013, The Journal of Biological Chemistry.

Virtual screening for small-molecule pathway regulators by image-profile matching.

Anne E Carpenter, Shantanu Singh, X. Varelas, 2022, Cell systems.

Discovery of small molecule pathway regulators by image 2 profile matching 3

Anne E Carpenter, Shantanu Singh, X. Varelas, 2021 .

Total RNA sequencing reveals gene expression and microbial alterations shared by oral pre-malignant lesions and cancer

Mohammed Muzamil Khan, S. Monti, X. Varelas, 2023, bioRxiv.