P. Chiba

发表

Clinical application of transcriptional activators of bile salt transporters☆

A. Baghdasaryan, P. Chiba, M. Trauner, 2014, Molecular aspects of medicine.

Flagging Drugs That Inhibit the Bile Salt Export Pump.

K. Kuchler, Tobias Noeske, S. Boyer, 2016, Molecular pharmaceutics.

Lead Identification for Modulators of Multidrug Resistance based on in silico Screening with a Pharmacophoric Feature Model

G. Ecker, T. Langer, R. Hoffmann, 2004, Archiv der Pharmazie.

Future directions for drug transporter modelling

P Chiba, S. Ekins, G. Ecker, 2007, Xenobiotica; the fate of foreign compounds in biological systems.

Estimation of the Chemosensitizing Activity of Modulators of Multi‐drug Resistance via Combined Simultaneous Analysis of Sigmoidal Dose‐Response Curves

G. Ecker, P. Chiba, K. Schaper, 1997, The Journal of pharmacy and pharmacology.

ABC Transporters – From Targets to Antitargets?

G. Ecker, P. Chiba, 2009 .

Inhibitors of ABC-type drug efflux pumps: an overview of the current patent situation

G. Ecker, P. Chiba, 2004 .

The importance of a nitrogen atom in modulators of multidrug resistance.

G Ecker, P Chiba, G. Ecker, 1999, Molecular pharmacology.

Substituted 4-acylpyrazoles and 4-acylpyrazolones: synthesis and multidrug resistance-modulating activity.

G Ecker, W Holzer, P Chiba, 1998, Journal of medicinal chemistry.

COMPOUNDS FOR TREATING MULTIDRUG RESISTANCE

P. Chiba, 2017 .

Fabrication of psoralen-loaded lipid-polymer hybrid nanoparticles and their reversal effect on drug resistance of cancer cells.

P. Chiba, R. Callaghan, S. Cole, 2018, Oncology reports.

Intrinsic and Acquired Forms of Resistance against the Anticancer Ruthenium Compound KP1019 [Indazolium trans-[tetrachlorobis(1H-indazole)ruthenate (III)] (FFC14A)

W. Berger, P. Chiba, B. Marian, 2005, Journal of Pharmacology and Experimental Therapeutics.

Dissecting the Forces that Dominate Dimerization of the Nucleotide Binding Domains of ABCB1

G. Szakács, T. Stockner, P. Chiba, 2018, Biophysical journal.

Phospholipases in biology and medicine.

Khaled M. Zaky, P. Chiba, E. Kaiser, 1990, Clinical biochemistry.

Targeting drug-efflux pumps -- a pharmacoinformatic approach.

G. Ecker, P. Chiba, Karin Pleban, 2005, Acta biochimica Polonica.

P-glycoprotein, multidrug resistance-associated proteins and human organic anion transporting polypeptide influence the intracellular accumulation of atazanavir

S. Khoo, P. Chiba, D. Back, 2009, Antiviral therapy.

Interaction of HM30181 with P-glycoprotein at the murine blood-brain barrier assessed with positron emission tomography.

C. Kuntner, P. Chiba, Z. Parveen, 2012, European journal of pharmacology.

Uptake of adenosine in human erythrocytes.

P. Chiba, M. Müller, M. Kraupp, 1979, Advances in experimental medicine and biology.

Interaction of ABC Transporters with Drugs

G. Ecker, P. Chiba, F. Nasim, 2016 .

Recent Advances in Structural Modeling of ABC Transporters

G. Ecker, P. Chiba, D. Haake, 2017 .

Recent developments in overcoming tumour cell multi-drug resistance

G. Ecker, P. Chiba, 1997 .

Antiplasmodial activity of flavonol quercetin and its analogues in Plasmodium falciparum: evidence from clinical isolates in Bangladesh and standardized parasite clones

P. Chiba, W. Khan, H. Fuehrer, 2012, Parasitology Research.

Radiosynthesis and in vivo evaluation of 1-[18F]fluoroelacridar as a positron emission tomography tracer for P-glycoprotein and breast cancer resistance protein.

Donald W. Miller, W. Löscher, C. Kuntner, 2011, Bioorganic & medicinal chemistry.

Glibenclamide reduces proinflammatory cytokines in an ex vivo model of human endotoxinaemia under hypoxaemic conditions.

M. Svoboda, T. Thalhammer, P. Chiba, 2011, Life sciences.

Pinacidil-primed ATP-sensitive potassium channels mediate feedback control of mechanical power output in isolated myocardium of rats and guinea pigs.

P. Chiba, D. Staudacher, T. Moeslinger, 2010, European journal of pharmacology.

Remodeling the regulation of iron metabolism during erythroid differentiation to ensure efficient heme biosynthesis.

H. Beug, P. Chiba, M. Schranzhofer, 2006, Blood.

Pharmacological correction of misfolding of ABC proteins☆

T. Stockner, P. Chiba, M. Trauner, 2014, Drug discovery today. Technologies.

Subtle Structural Differences Trigger Inhibitory Activity of Propafenone Analogues at the Two Polyspecific ABC Transporters: P‐Glycoprotein (P‐gp) and Breast Cancer Resistance Protein (BCRP)

K. Kuchler, G. Ecker, Katrin Wlcek, 2016, ChemMedChem.

Synergistic action of tiazofurin with hypoxanthine and allopurinol in human neuroectodermal tumor cell lines.

T. Szekeres, P. Chiba, C. Lhotka, 1993, Biochemical pharmacology.

Uptake of AMP into K 562 and HL-60 leukemic cell lines.

P. Chiba, H. Rumpold, M. Müller, 1984, Advances in experimental medicine and biology.

Regulation of purine uptake in normal and neoplastic cells.

P. Chiba, H. Rumpold, M. Müller, 1983, Advances in enzyme regulation.

Simvastatin-induced compartmentalisation of doxorubicin sharpens up nuclear topoisomerase II inhibition in human rhabdomyosarcoma cells

M. Hohenegger, P. Chiba, M. Werner, 2013, Naunyn-Schmiedeberg's Archives of Pharmacology.

Interactions between ABC-transport proteins and the secondary Fusarium metabolites enniatin and beauvericin.

W. Berger, M. Sulyok, P. Chiba, 2009, Molecular nutrition & food research.

Probing the stereoselectivity of P-glycoprotein-synthesis, biological activity and ligand docking studies of a set of enantiopure benzopyrano[3,4-b][1,4]oxazines.

G. Ecker, P. Chiba, Z. Parveen, 2011, Chemical communications.

Metabolic preconditioning protects BSEP/ABCB11-/- mice against cholestatic liver injury.

P. Chiba, M. Trauner, T. Stojaković, 2017, Journal of hepatology.

COMPARISON OF DIFFERENT METHODS FOR ESTIMATION OF LIPOPHILICITY OF PROPAFENONE-TYPE MODULATORS OF MULTIDRUG RESISTANCE

G. Ecker, P. Chiba, S. Prets, 1996 .

Concordant changes of pyrimidine metabolism in blasts of two cases of acute myeloid leukemia after repeated treatment with ara-C in vivo.

T. Szekeres, W. Knapp, P. Chiba, 1990, Leukemia.

The Bile Salt Export Pump: Molecular Structure, Study Models and Small-Molecule Drugs for the Treatment of Inherited BSEP Deficiencies

T. Stockner, P. Chiba, M. I. Sohail, 2021, International journal of molecular sciences.

Aluminum ions stimulate the oxidizability of low density lipoprotein by Fe2+: Implication in hemodialysis mediated atherogenic LDL modification

P. Chiba, B. Gmeiner, B. Scheiber-Mojdehkar, 2005, Free radical research.

Hydrophobic moments as physicochemical descriptors in structure-activity relationship studies of P-glycoprotein inhibitors

G. Ecker, P. Chiba, G. König, 2008 .

Adenine and hypoxanthine transport in human erythrocytes: distinct substrate effects on carrier mobility.

P. Chiba, M. Razavi, M. Baghestanian, 1991, Biochimica et biophysica acta.

An abundant, truncated human sulfonylurea receptor 1 splice variant has prodiabetic properties and impairs sulfonylurea action

P. Chiba, A. Assinger, T. Moeslinger, 2011, Cellular and Molecular Life Sciences.

Concentration-dependent effects and intracellular accumulation of HIV protease inhibitors in cultured CD4 T cells and primary human lymphocytes.

S. Khoo, P. Chiba, E. Jones, 2010, The Journal of antimicrobial chemotherapy.

Synthesis and in vitro multidrug resistance modulating activity of a series of dihydrobenzopyrans and tetrahydroquinolines.

Gerhard F. Ecker, Peter Chiba, Christian Wolf, 1999, Journal of medicinal chemistry.

Synthesis, biological evaluation and 3D-QSAR studies of new chalcone derivatives as inhibitors of human P-glycoprotein.

G. Ecker, P. Chiba, Z. Parveen, 2014, Bioorganic & medicinal chemistry.

Self-organizing maps for identification of new inhibitors of P-glycoprotein.

Johann Gasteiger, Stephan Kopp, Dominik Kaiser, 2007, Journal of medicinal chemistry.

Combination chemotherapy directed at the components of nucleoside diphosphate reductase.

J. G. Cory, P. Chiba, 1985, Pharmacology & therapeutics.

Structure–Activity Relationships, Ligand Efficiency, and Lipophilic Efficiency Profiles of Benzophenone-Type Inhibitors of the Multidrug Transporter P-Glycoprotein

G. Ecker, P. Chiba, Ishrat Jabeen, 2012, Journal of medicinal chemistry.

Synthesis, structures and anti-malaria activity of some gold(I) phosphine complexes containing seleno- and thiosemicarbazonato ligands.

P. Chiba, G. Deepa, F. Mohr, 2011, Dalton transactions.

Synthesis and biological studies of some gold(I) complexes containing functionalised alkynes.

P. Chiba, M. Jakupec, B. Keppler, 2009, Dalton transactions.

Purine and Pyrimidine Metabolism in Man IX

A. Griesmacher, P. Chiba, MATHIAS M. MüLLER, 1998, Advances in Experimental Medicine and Biology.

State of the art of overcoming efflux transporter mediated multidrug resistance of breast cancer

P. Chiba, Qianwen Li, Yu Cai, 2019, Translational cancer research.

Antiplasmodial activity of flavonol quercetin and its analogues in Plasmodium falciparum: evidence from clinical isolates in Bangladesh and standardized parasite clones

P. Chiba, W. Khan, H. Fuehrer, 2012, Parasitology Research.

Multidrug-resistant cancer cells are preferential targets of the new antineoplastic lanthanum compound KP772 (FFC24).

C. Pirker, W. Berger, P. Chiba, 2007, Biochemical pharmacology.

Psoralen-loaded lipid-polymer hybrid nanoparticles enhance doxorubicin efficacy in multidrug-resistant HepG2 cells

P. Chiba, R. Callaghan, Qianqian Ma, 2019, International journal of nanomedicine.

Investigation of cytotoxic effects of 8 norbornane derivatives on 4 human cancer cell lines using the MTT assay.

W. Jäger, P. Chiba, G. Buchbauer, 1995, Die Pharmazie.

Nuclear Medicine and Biology

N. Colabufo, C. Kuntner, P. Chiba, 2012 .

Furine Metabolism of Human Glioblastoma in Vivo1

H. Kostron, P. Chiba, B. Czermak, 2006 .

Cytotoxicity, differentiating activity and metabolism of tiazofurin in human neuroblastoma cells

T. Szekeres, P. Chiba, S. Szalay, 1993, International journal of cancer.

GM‐CSF: modulation of biochemical and cytotoxic effects of tiazofurin in HL‐60 cells

T. Szekeres, P. Chiba, M. Fritzer, 1993, British journal of haematology.

Purine metabolism of human glioblastoma in vivo.

P Chiba, P. Chiba, B. Czermak, 1990, Cancer research.

Defining the blanks – Pharmacochaperoning of SLC6 transporters and ABC transporters?

T. Stockner, P. Chiba, M. Freissmuth, 2014, Pharmacological research.

2D- and 3D-QSAR studies of a series of benzopyranes and benzopyrano[3,4b][1,4]-oxazines as inhibitors of the multidrug transporter P-glycoprotein

Gerhard F. Ecker, Peter Chiba, Manuel Pastor, 2013, Journal of Computer-Aided Molecular Design.

Nanoparticle delivery of anticancer drugs overcomes multidrug resistance in breast cancer

P. Chiba, Ronghua Zhang, Yu Cai, 2016, Drug delivery.

Synthesis and preclinical evaluation of the radiolabeled P-glycoprotein inhibitor [(11)C]MC113.

N. Colabufo, C. Kuntner, P. Chiba, 2012, Nuclear medicine and biology.

Data‐driven homology modelling of P‐glycoprotein in the ATP‐bound state indicates flexibility of the transmembrane domains

Alexandre M J J Bonvin, Peter Chiba, Sjoerd J de Vries, 2009, The FEBS journal.

Computational models for prediction of interactions with ABC-transporters.

Gerhard F. Ecker, Peter Chiba, Thomas Stockner, 2008, Drug discovery today.

In silico screening with benzofurane- and benzopyrane-type MDR-modulators.

G. Ecker, T. Langer, C. Noe, 2003, Farmaco.

Enzymological aspects of disorders in purine metabolism.

P. Chiba, M. Müller, M. Kraupp, 1983, Clinical biochemistry.

Human ABCB1 with an ABCB11-like degenerate nucleotide binding site maintains transport activity by avoiding nucleotide occlusion

G. Szakács, T. Stockner, P. Chiba, 2020, PLoS genetics.

Active transport of rhodamine 123 by the human multidrug transporter P‐glycoprotein involves two independent outer gates

G. Szakács, H. Sitte, T. Stockner, 2020, Pharmacology research & perspectives.

Folding correction of ABC‐transporter ABCB1 by pharmacological chaperones: a mechanistic concept

G. Ecker, T. Stockner, P. Chiba, 2017, Pharmacology research & perspectives.

Molecular Dissection of Dual Pseudosymmetric Solute Translocation Pathways in Human P-Glycoprotein

Zahida Parveen, Peter Chiba, Thomas Stockner, 2011, Molecular Pharmacology.

Multispecificity of Drug Transporters: Probing Inhibitor Selectivity for the Human Drug Efflux Transporters ABCB1 and ABCG2

Stephan Kopp, Peter Chiba, Gerhard F Ecker, 2007, ChemMedChem.

A Three-Dimensional Model for the Substrate Binding Domain of the Multidrug ATP Binding Cassette Transporter LmrA

G. Ecker, M. Putman, W. Konings, 2004, Molecular Pharmacology.

Identification of ligand-binding regions of P-glycoprotein by activated-pharmacophore photoaffinity labeling and matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry.

Stephan Kopp, Wolfgang Holzer, Peter Chiba, 2002, Molecular pharmacology.

Structure-activity relationship studies of propafenone analogs based on P-glycoprotein ATPase activity measurements.

G Ecker, P Chiba, G. Ecker, 1999, Biochemical pharmacology.

A radiochemical microassay of S-adenosylhomocysteine hydrolase in lymphoid cells.

W. Dinjens, P. Chiba, C. De Bruyn, 1985, Clinica chimica acta; international journal of clinical chemistry.

Structure-activity relationship studies on benzofuran analogs of propafenone-type modulators of tumor cell multidrug resistance.

K J Schaper, G Ecker, P Chiba, 1996, Journal of medicinal chemistry.

Synthesis, pharmacologic activity, and structure-activity relationships of a series of propafenone-related modulators of multidrug resistance.

G Ecker, P Chiba, E Richter, 1995, Journal of medicinal chemistry.

Pore-Exposed Tyrosine Residues of P-Glycoprotein Are Important Hydrogen-Bonding Partners for Drugs

H. Sitte, G. Ecker, T. Stockner, 2014, Molecular Pharmacology.

The SYBR Green I malaria drug sensitivity assay: performance in low parasitemia samples.

P. Chiba, H. Noedl, M. Vossen, 2010, The American journal of tropical medicine and hygiene.

Cell cycle dependent regulation of IMP dehydrogenase activity and effect of tiazofurin.

P Chiba, T. Szekeres, T. Felzmann, 1992, Life sciences.

Antimalarial and antitrypanosomal activity of a series of amide and sulfonamide derivatives of a 2,5-diaminobenzophenone.

S. Heinrich, M. Schlitzer, P. Chiba, 2009, Bioorganic & medicinal chemistry.

Studies directed toward testing the "channeling" hypothesis--ribonucleotides----DNA in leukemia L1210 cells.

J. G. Cory, P. Chiba, P. E. Bacon, 1984, Biochemical and biophysical research communications.

S-adenosylmethionine metabolism in HL-60 cells: effect of cell cycle and differentiation.

P. Chiba, E. Kaiser, C. Wallner, 1988, Biochimica et biophysica acta.

An unsuspected role for organic cation transporter 3 in the actions of amphetamine

H. Sitte, W. Koek, W. A. Owens, 2018, Neuropsychopharmacology.

CTP: CMP phosphotransferase activity in L1210 cells.

J. G. Cory, P. Chiba, 1988, Cancer biochemistry biophysics.

P-Glycoprotein Substrate Binding Domains Are Located at the Transmembrane Domain/Transmembrane Domain Interfaces: A Combined Photoaffinity Labeling-Protein Homology Modeling Approach

Stephan Kopp, Peter Chiba, Andreas Rizzi, 2005, Molecular Pharmacology.

Aqueous extracts of Cimicifuga racemosa and phenolcarboxylic constituents inhibit production of proinflammatory cytokines in LPS-stimulated human whole blood.

M. Svoboda, T. Thalhammer, P. Chiba, 2009, Canadian journal of physiology and pharmacology.

Effect of cell growth and cell differentiation on 1‐β‐d‐arabinofuranosylcytosine metabolism in myeloid cells

P. Chiba, T. Tihan, W. Linkesch, 1989, British journal of haematology.

Simvastatin-induced compartmentalisation of doxorubicin sharpens up nuclear topoisomerase II inhibition in human rhabdomyosarcoma cells

M. Hohenegger, P. Chiba, M. Werner, 2013, Naunyn-Schmiedeberg's Archives of Pharmacology.

Structural requirements for activity of propafenone-type modulators in P-glycoprotein-mediated multidrug resistance.

G Ecker, P Chiba, G. Ecker, 1996, Molecular pharmacology.

Catalytic cycle of ATP hydrolysis by P-glycoprotein: evidence for formation of the E.S reaction intermediate with ATP-gamma-S, a nonhydrolyzable analogue of ATP.

Stephan Kopp, In-Wha Kim, Peter Chiba, 2007, Biochemistry.

Conversion of chemical to mechanical energy by the nucleotide binding domains of ABCB1

G. Szakács, T. Stockner, P. Chiba, 2020, Scientific Reports.

A Pilot Study to Assess the Efficacy of Tariquidar to Inhibit P-glycoprotein at the Human Blood–Brain Barrier with (R)-11C-Verapamil and PET

Stephan Kopp, Peter Chiba, Wolfgang Löscher, 2009, Journal of Nuclear Medicine.

Molecular Mechanism of Taurocholate Transport by the Bile Salt Export Pump, an ABC Transporter Associated with Intrahepatic Cholestasis

G. Szakács, Katrin Wlcek, T. Stockner, 2017, Molecular Pharmacology.

Similarity‐Based Descriptors (SIBAR) as Tool for QSAR Studies on P‐Glycoprotein Inhibitors: Influence of the Reference Set

Barbara Zdrazil, Stephan Kopp, Gerhard F. Ecker, 2007 .

Using structural and mechanistic information to design novel inhibitors/substrates of P-glycoprotein.

Markus Müller, Peter Chiba, Thomas Stockner, 2010, Current topics in medicinal chemistry.

Serum lipid peroxide levels in the course of coronary by-pass surgery.

P. Chiba, T. Tihan, M. Fritzer, 1992, European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies.

The Q loops of the human multidrug resistance transporter ABCB1 are necessary to couple drug binding to the ATP catalytic cycle

K. Linton, P. Chiba, A. Seelig, 2014, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Photoaffinity labeling of P-glycoprotein.

P. Chiba, E. Csaszar, S. Kopp, 2005, Mini reviews in medicinal chemistry.

Exhaustive Sampling of Docking Poses Reveals Binding Hypotheses for Propafenone Type Inhibitors of P-Glycoprotein

Gerhard F. Ecker, Peter Chiba, Freya Klepsch, 2011, PLoS Comput. Biol..

S-Adenosylhomocysteine hydrolase activity during differentiation of HL-60 cells

P. Chiba, C. Bruyn, A. Plas, 1984, Bioscience reports.

Characterization of an adenine phosphoribosyltransferase deficiency.

P. Chiba, M. Müller, K. Zwiauer, 1988, Clinica chimica acta; international journal of clinical chemistry.

A Subset of Highly Effective Propafenone-Type Multidrug Resistance Modulators Lacks Effects on Cardiac Action Potential and Mechanical Twitch Parameters of Rat Papillary Muscles

G. Ecker, P. Chiba, D. Staudacher, 2003, Journal of Pharmacology and Experimental Therapeutics.

Similarity based SAR (SIBAR) as tool for early ADME profiling

Stephan Kopp, Gerhard F. Ecker, Christian Th. Klein, 2002, J. Comput. Aided Mol. Des..

Characterization of a novel class of antimalarials and its applicability to plasmodial target identification

G. Ecker, P. Chiba, K. Thriemer, 2007, Wiener klinische Wochenschrift.

Homology model of the multidrug transporter LmrA from Lactococcus lactis.

G. Ecker, P. Chiba, G. Costantino, 2004, Bioorganic & medicinal chemistry letters.

Computational models for prediction of interactions with ABC-transporters.

G. Ecker, T. Stockner, P. Chiba, 2008, Drug discovery today.

An abundant, truncated human sulfonylurea receptor 1 splice variant has prodiabetic properties and impairs sulfonylurea action

P. Chiba, A. Assinger, T. Moeslinger, 2011, Cellular and Molecular Life Sciences.

Structure-activity-relationship studies on modulators of the multidrug transporter P-glycoprotein--an overview.

G. Ecker, P. Chiba, 1995, Wiener klinische Wochenschrift.

Fabrication of psoralen-loaded lipid-polymer hybrid nanoparticles and their reversal effect on drug resistance of cancer cells.

P. Chiba, R. Callaghan, S. Cole, 2018, Oncology reports.

Transporters as drug carriers : structure, function, substrates

G. Ecker, P. Chiba, 2009 .

MCASE study of the multidrug resistance reversal activity of propafenone analogs

Hao Zhu, Gerhard F. Ecker, Gilles Klopman, 2003, J. Comput. Aided Mol. Des..

Attachment of VLDL receptors to an icosahedral virus along the 5-fold symmetry axis: multiple binding modes evidenced by fluorescence correlation spectroscopy.

P. Chiba, D. Blaas, G. Köhler, 2007, Biochemistry.