J. Dingle

发表

The effects of proteolytic enzymes on the mechanical properties of adult human articular cartilage.

G E Kempson, M A Tuke, M. Tuke, 1976, Biochimica et biophysica acta.

Action of Saponin on Biological Cell Membranes

J. Lucy, J. Dingle, A. Glauert, 1962, Nature.

The role of cytokines in arthritic diseases: in vitro and in vivo measurements of cartilage degradation.

J. Dingle, B. Hazleman, D. P. Page Thomas, 1987, International journal of tissue reactions.

Liposome-incorporated corticosteroids. II. Therapeutic activity in experimental arthritis.

J. Dingle, N. Phillips, C. G. Knight, 1979, Annals of the rheumatic diseases.

Liposomal retention of a modified anti-inflammatory steroid.

J. Dingle, C. G. Knight, I. H. Shaw, 1976, The Biochemical journal.

VITAMIN A, CAROTENOIDS AND CELL FUNCTION

J. Lucy, J. Dingle, 1965, Biological reviews of the Cambridge Philosophical Society.

Lysosomal alterations in autolyzing rabbit heart.

J. Dingle, A. Poole, K. Wildenthal, 1979, Journal of molecular and cellular cardiology.

Altered distribution of lysosomal cathepsin D in ischemic myocardium.

J. Dingle, A. Poole, K. Wildenthal, 1977, The Journal of clinical investigation.

Influence of methylprednisolone of the sequential redistribution of cathepsin D and other lysosomal enzymes during myocardial ischemia in rabbits.

J. Dingle, A. Poole, K. Wildenthal, 1978, The Journal of clinical investigation.

Lysosomal alterations in hypoxic and reoxygenated hearts. II. Immunohistochemical and biochemical changes in cathepsin D.

J. Dingle, K. Wildenthal, A. Robin Poole, 1980, The American journal of pathology.

Comparison of the effects of vitamin A and its analogs upon rabbit ear cartilage in organ culture and upon growth of the vitamin A-deficient rat.

J. Dingle, R. Hembry, J. Smith, 1974, Journal of lipid research.

Influence of starvation on the activities and localization of cathepsin D and other lysosomal enzymes in hearts of rabbits and mice.

J. Dingle, A. Poole, K. Wildenthal, 1975, Journal of molecular and cellular cardiology.

Expression of intercellular adhesion molecule 1 (ICAM-1) on human articular cartilage chondrocytes.

J. Dingle, C. Power, R. Pigott, 1991, Connective tissue research.

In vitro studies of rheumatoid synovium; preliminary metabolic comparison between synovial membrane and villi.

J. Dingle, D. P. Thomas, 1955, British journal of experimental pathology.

Bone Resorption in Vitro and its Inhibition by Calcitonin

J. Dingle, J. Reynolds, I. Macintyre, 1968 .

Subcellular distribution of lead in the rat.

J. Dingle, A. J. Barrett, D. Barltrop, 1971, The Journal of laboratory and clinical medicine.

Sequential lysosomal alterations during cardiac ischemia. I. Biochemical and immunohistochemical changes.

J. Dingle, A. Poole, K. Wildenthal, 1978, Laboratory investigation; a journal of technical methods and pathology.

A sensitive in vitro method for studying the induction and inhibition of bone resorption

J. Dingle, J. Reynolds, 2005, Calcified Tissue Research.

Cardiac catabolic factors: the degradation of heart valve intercellular matrix.

J. Dingle, R. Decker, 1982, Science.

A cartilage catabolic factor from synovium.

J. Dingle, J. Saklatvala, R. Jubb, 1979, The Biochemical journal.

THE ACTION OF EXCESS OF VITAMIN A ALCOHOL ON THE FINE STRUCTURE OF RAT DERMAL FIBROBLASTS

J. Lucy, J. Dingle, A. Glauert, 1966, The Journal of cell biology.

Non-steroidal, Anti-inflammatory Drug Administration in the Treatment of Osteoarthritis

J. Dingle, 1999 .

NSAIDs and human cartilage metabolism

J. Dingle, 1992 .

IMMUNOINHIBITION OF INTRACELLULAR PROTEIN DIGESTION IN MACROPHAGES

A. Barrett, J. Dingle, A. Poole, 1973, The Journal of experimental medicine.

Cathepsins BI and D. Action on human cartilage proteoglycans.

J. Dingle, A. J. Barrett, D. Prior, 1973, Biochimica et biophysica acta.

THE IMMUNOCYTOCHEMICAL DEMONSTRATION OF CATHEPSIN D

J. Dingle, A. J. Barrett, A. Poole, 1972, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

The localization of retinol-binding protein in rat liver by immunofluorescence microscopy.

J. Dingle, D. Goodman, A. Robin Poole, 1975, Journal of cell science.

Secretion and localization of cathepsin D in synovial tissues removed from rheumatoid and traumatized joints. An immunohistochemical study.

E. Ring, J. Dingle, A. Poole, 1976, Arthritis and rheumatism.

The inhibition of tissue acid proteinases by pepstatin.

J. Dingle, A. J. Barrett, 1972, The Biochemical journal.

The breakdown of embryonic (chick) cartilage and bone cultivated in the presence of complement-sufficient antiserum. 3. Immunological analysis.

P. Lachmann, J. Dingle, R. Coombs, 1966, International archives of allergy and applied immunology.

Endocytosis of sugars in embryonic skeletal tissues in organ culture. IV. Lysosomal and other biochemical effects. General discussion.

J. Dingle, A. Glauert, H. B. Fell, 1969, Journal of cell science.

Heberden oration 1978. Recent studies on the control of joint damage: the contribution of the Strangeways Research Laboratory.

J. Dingle, 1979, Annals of the rheumatic diseases.

In vitro studies on human synovial membrane; a metabolic comparison of normal and rheumatoid tissue.

J. Dingle, D. P. Thomas, 1956, British journal of experimental pathology.

Lysosomal Alterations in Hypoxic and Reoxygenated Hearts

J. Dingle, K. Wildenthal, R. Decker, 2007 .

I. Ultrastructural and Cytochemical Changes

J. Dingle, K. Wildenthal, R. Decker, 2007 .

Novel treatment for joint inflammation

J. Dingle, B. Hazleman, N. Phillips, 1978, Nature.

Rabbit cranial sutures in vitro: A new experimental model for studying the response of fibrous joints to mechanical stress

J. Dingle, J. Reynolds, M. Meikle, 1979, Calcified Tissue International.

The effect of nonsteroidal antiinflammatory drugs on human articular cartilage glycosaminoglycan synthesis.

J. Dingle, 1999, Osteoarthritis and cartilage.

Prostaglandins in human cartilage metabolism.

J. Dingle, 1993, Journal of lipid mediators.

Cartilage maintenance in osteoarthritis: interaction of cytokines, NSAID and prostaglandins in articular cartilage damage and repair.

J. Dingle, 1991, The Journal of rheumatology. Supplement.

The site of cartilage matrix degradation.

J. Dingle, T. Dingle, 1980, The Biochemical journal.

The breakdown of embryonic (chick) cartilage and bone cultivated in the presence of complement-sufficient antiserum. I. Morphological changes, their reversibility and inhibition.

J. Dingle, R. Coombs, H. B. Fell, 1966, International archives of allergy and applied immunology.

Identification of catabolin, a protein fro synovium which induces degradation of cartilage in organ culture.

J. Dingle, J. Saklatvala, 1980, Biochemical and biophysical research communications.

In vivo studies of articular tissue damage mediated by catabolin/interleukin 1.

J. Dingle, D. P. Page Thomas, D. Bard, 1987, Annals of the rheumatic diseases.

The sensitivity of synthesis of human cartilage matrix to inhibition by IL‐1 suggests a mechanism for the development of osteoarthritis

J. Dingle, A. Horner, M. Shield, 1991, Cell biochemistry and function.

Proceedings: Extracellular release of cathepsin D from cells in human normal and rheumatoid.

E. Ring, J. Dingle, A. Poole, 1974, Annals of the Rheumatic Diseases.

Studies on the mode of action of excess of vitamin A. 6. Lysosomal protease and the degradation of cartilage matrix.

J. Dingle, H. B. Fell, 1963, The Biochemical journal.

STUDIES ON THE MODE OF ACTION OF EXCESS OF VITAMIN A

J. Lucy, J. Dingle, A. Glauert, 1963, The Journal of cell biology.

Human mononuclear cell factors mediate cartilage matrix degradation through chondrocyte activation.

J. Dingle, H. Jasin, 1981, The Journal of clinical investigation.

Proteoglycan-degrading enzymes of rabbit fibroblasts and granulocytes.

Z. Werb, A. Barrett, J. Dingle, 1978, The Biochemical journal.

Intracellular catabolin-like activity in cultured synovial tissue

J. Dingle, Erjia Qi, 1983, In Vitro.

Porcine Heart Valves Produce a Protein That Induces Cell‐Mediated Connective Tissue Degradation: I. Biological Properties

J. Dingle, A. Henney, R. Decker, 1986, Circulation research.

Porcine Heart Valves Produce a Protein that Induces Cell‐Mediated Connective Tissue Degradation: II. Biochemical Properties of the Partially Purified Protein

J. Dingle, A. Henney, R. Decker, 1986, Circulation research.

The effect of synovial catabolin on cartilage synthetic activity.

J. Dingle, 1984, Connective tissue research.

The Role of Catabolins in Synovia-Chondrocyte Interactions

J. Dingle, 1983 .

Effects of antirheumatoid drugs on the production and action of porcine catabolin.

J. Dingle, B. Hazleman, H. Sheppeard, 1982, Annals of the rheumatic diseases.

A possible role for catabolin in tissue remodelling and repair.

J. Dingle, 1981, Ciba Foundation symposium.

The role of 'Catabolin' in arthritic damage.

J. Dingle, 1980, Agents and actions. Supplements.

Studies on the mode of action of excess of vitamin A. 2. A possible role of intracellular proteases in the degradation of cartilage matrix.

J. Lucy, J. Dingle, H. B. Fell, 1961, The Biochemical journal.

Studies on the mode of action of excess of vitamin A. 9. Penetration of lipid monolayers by compounds in the vitamin A series.

J. Lucy, A. Bangham, J. Dingle, 1964, The Biochemical journal.

Royal Academy of Medicine in Ireland Section of Biomedical Sciences

C. G. Lyons, B. Schreiber, R. Huiskes, 1997 .

Endocytosis of sugars in embryonic skeletal tissues in organ culture. II. Effect of sucrose on cellular fine structure.

J. Dingle, A. Glauert, H. B. Fell, 1969, Journal of cell science.

Nutrition and lysosomal activity. The influence of the vitamin A status on the proteolytic activity of extracts from the livers and kidneys of rats.

J. Dingle, I. Sharman, T. Moore, 1966, The Biochemical journal.

Membrane phenomenons in relation to vitamin A

J. Lucy, J. Dingle, 1965, Proceedings of the Nutrition Society.

Studies on the mode of action of excess of vitamin A. 5. The effect of vitamin A on the stability of the erythrocyte membrane.

J. Lucy, J. Dingle, 1962, The Biochemical journal.

STUDIES ON THE MODE OF ACTION OF EXCESS OF VITAMIN A. 8. MITOCHONDRIAL SWELLING.

J. Lucy, J. Dingle, M. Luscombe, 1963, The Biochemical journal.

Experimental model for scleritis.

J. Dingle, R. Hembry, P. Watson, 1979, Archives of ophthalmology.

Studies on the mode of action of excess of vitamin A. 3. Release of a bound protease by the action of vitamin A.

J. Dingle, J. Dingle, 1961, The Biochemical journal.

Fat-Soluble Vitamins and Biological Membranes

J. Lucy, J. Dingle, 1964, Nature.

Cathepsin D. Characteristics of immunoinhibition and the confirmation of a role in cartilage breakdown.

J. Dingle, A. J. Barrett, P. Weston, 1971, The Biochemical journal.

Studies on the mode of action of excess of vitamin A. 4. The specificity of the effect on embryonic chick-limb cartilage in culture and on isolated rat-liver lysosomes.

J. Dingle, M. Webb, H. B. Fell, 1962, The Biochemical journal.

Studies on the mode of action of excess of vitamin A. 1. Effect of excess of vitamin A on the metabolism and composition of embryonic chick-limb cartilage grown in organ culture.

J. Lucy, J. Dingle, H. B. Fell, 1961, The Biochemical journal.

Cobalt-tolerance and mucopolysaccharide production in rat dermal fibroblasts in culture.

J. Lucy, J. Dingle, M. Daniel, 1961, Experimental cell research.

Liposome-incorporated corticosteroids: I. The interaction of liposomal cortisol palmitate with inflammatory synovial membrane.

J. Dingle, N. Phillips, C. G. Knight, 1979, British journal of experimental pathology.

Microassay for cathepsin D shows an unexpected effedt of cycloheximide on limb-bone rudiments in organ culture.

J. Dingle, A. J. Barrett, M. B. Hille, 1970, Experimental cell research.

J. Dingle, A. Poole, K. Wildenthal, 1977, Journal of molecular and cellular cardiology.

The effect of retinol and of retinol-binding protein on embryonic skeletal tissue in organ culture.

J. Dingle, D. Goodman, H. B. Fell, 1972, Journal of cell science.

The effects of vitamin A (retinol) on cell growth and incorporation of labelled glucosamine and proline fy mouse fibroblasts in culture.

J. Lucy, J. Dingle, D. M. Kochhar, 1968, Experimental cell research.

Inhibition by pepstatin of human cartilage degradation.

P. Stovin, J. Dingle, A. J. Barrett, 1972, The Biochemical journal.

Nutrition and lysosomal activity. The effect of dietary cod-liver oil on the distribution of polyunsaturated fatty acids in the kidney lysosomes of rats receiving deficient or adequate intakes of vitamin E

J. Dingle, I. Sharman, M. Iqbal, 1969, British Journal of Nutrition.

Proteoglycan-degrading enzymes. A radiochemical assay method and the detection of a new enzyme cathepsin F.

A. Barrett, J. Dingle, P. E. Martin, 1977, The Biochemical journal.

Effect of Hydrocortisone and ε-Amino Caproic Acid on Immune Cytolysis in vitro

J. Dingle, R. Coombs, R. Spooner, 1966 .

Synthesis of connective-tissue components. The effect of retinol and hydrocortisone on cultured limb-bone rudiments.

J. Lucy, J. Dingle, H. B. Fell, 1966, The Biochemical journal.

Binding of radiolabelled collagen to blood platelets.

J. Dingle, J. L. Gordon, 1974, Journal of cell science.

Articular damage in arthritis and its control.

J. Dingle, 1978, Annals of internal medicine.

Metalloproteinase production by rabbit articular cartilage: comparison of the effects of interleukin-1α in vitro and in vivo

J. Dingle, R. Hembry, M. Bagga, 2004, Virchows Archiv.

Immunohistological identification of interleukin-1 activated chondrocytes.

J. Dingle, M. Davies, B. Y. Mativi, 1990, Annals of the rheumatic diseases.

Characterization of a specific antiserum for mammalian collagenase from several species: immunolocalization of collagenase in rabbit chondrocytes and uterus.

J. Dingle, R. Hembry, J. Reynolds, 1986, Journal of cell science.

Effects of indomethacin on ICAM-1 expression and adhesion of T lymphocytes to chondrocytes

J. Dingle, A. Horner, M. Vies, 1993, InflammoPharmacology.

Immunorecognition of chondrocytes in articular cartilage activated by synovial interleukin 1.

J. Dingle, A. Horner, M. Davies, 1991, Connective tissue research.

In vivo studies of cartilage regeneration after damage induced by catabolin/interleukin-1.

J. Dingle, D. P. Page Thomas, T. Stephens, 1991, Annals of the rheumatic diseases.

Evidence that extracellular cathepsin D is not responsible for the resorption of cartilage matrix in culture.

A. Barrett, J. Dingle, R. Hembry, 1982, Biochimica et biophysica acta.

Catabolin--a cartilage catabolic factor from synovium.

J. Dingle, 1981, Clinical orthopaedics and related research.

Effect of tenidap on cartilage integrity in vitro.

J. Dingle, M. Leeming, J. Martindale, 1993, Annals of the rheumatic diseases.

A sensitiviein vitro method for studying the induction and inhibition of bone resorption

J. Dingle, J. Reynolds, 1969, Calcified Tissue Research.

Time Course of Action of Calcitonin on Resorbing Mouse Bones in vitro

J. Dingle, J. Reynolds, 1968, Nature.

Effects of methylprednisolone on lysosomal cathepsin D in ischemic myocardium

J. Dingle, A. Poole, K. Wildenthal, 1978 .

Breakdown of proteoglycan and collagen induced in pig articular cartilage in organ culture.

J. Dingle, P. Horsfield, H. B. Fell, 1975, Annals of the rheumatic diseases.

Production of cartilage degrading activity by human synovial tissues.

J. Dingle, B. Hazleman, D. Dandy, 1987, Annals of the rheumatic diseases.

The role of catabolin in the control of cartilage matrix integrity.

J. Dingle, 1983, The Journal of rheumatology. Supplement.

THE REVERSIBLE “DEDIFFERENTIATION” OF EMBRYONIC SKELETAL TISSUES IN CULTURE IN RESPONSE TO COMPLEMENT-SUFFICIENT ANTISERUM

P. Lachmann, J. Dingle, R. Coombs, 1968 .

The breakdown of embryonic cartilage and bone cultivated in the presence of complement-sufficient antiserum. 2. Biochemical changes and the role of the lysosomal system.

J. Dingle, R. Coombs, H. B. Fell, 1967, International archives of allergy and applied immunology.

Lysosomes as modulators of cellular functions. Influence on the synthesis and secretion of non-lysosomal materials.

Z. Werb, J. Dingle, Dingle Jt, 1976, Frontiers of biology.

Serum Antiplasmin and Plasmin in Rheumatoid Arthritis

J. Dingle, D. Thomas, 1955, Annals of the rheumatic diseases.

Clearance of proteoglycan from joint cavities.

J. Dingle, D. Bard, D. P. Page-Thomas, 1987, Annals of the rheumatic diseases.

Nutrition and lysosomal activity. The influence of vitamin E deficiency and its duration on the stability of lysosomes in the kidneys of rats.

J. Dingle, M. Stanton, I. Sharman, 1967, The Biochemical journal.

Endocytosis of sugars in embryonic skeletal tissues in organ culture. I. General introduction and histological effects.

J. Dingle, H. B. Fell, 1969, Journal of cell science.

NSAID Stimulation of Human Cartilage Matrix Synthesis

J. Dingle, M. Parker, 1997 .

The effect of NSAIDs on human articular cartilage glycosaminoglycan synthesis

J. Dingle, 1996 .

The role of cytokines and NSAIDs in osteoarthritis; the use of human cartilage in drug assessment

J. Dingle, 1992 .

Extracellular localization of cathepsin D in ossifying cartilage

J. Dingle, A. Poole, R. Hembry, 2005, Calcified Tissue Research.

Cathepsin D in cartilage: the immunohistochemical demonstration of extracellular enzyme in normal and pathological conditions.

J. Dingle, R. Hembry, A. Robin Poole, 1974, Journal of cell science.

Specific Inhibition of Cartilage Breakdown

J. Dingle, A. J. Barrett, P. Weston, 1969, Nature.

Interaction of dinitrophenyl-pepstatins with human cathepsin D and with anti-dinitrophenyl antibody. Development of potential reagents for the localization in vivo of active proteinases at sites of tissue injury.

J. Dingle, W. Hornebeck, R. Hembry, 1980, The Biochemical journal.

Endocytosis of sugars in embryonic skeletal tissues in organ culture. 3. Radioautographic distribution of [14C]sucrose.

J. Dingle, S. R. Pelc, T. Appleton, 1969, Journal of cell science.

Uptake of biologically active substances by lysosomes

J. Dingle, A. J. Barrett, 1969, Proceedings of the Royal Society of London. Series B. Biological Sciences.

The effects of NSAID on the matrix of human articular cartilages

J. Dingle, 1999, Zeitschrift für Rheumatologie.

Studies on human synovial membrane in vitro; the metabolism of normal and rheumatoid synovia and the effect of hydrocortisone.

J. Dingle, D. Thomas, 1958, The Biochemical journal.

The sulphated glycosaminoglycan levels in synovial fluid aspirates in patients with acute and chronic joint disease.

J. Dingle, B. Hazleman, B. Silverman, 1990, British journal of rheumatology.

Lyososomes in biology and pathology. 1.

J. Dingle, H. B. Fell, 1969 .

THE JOURNAL OF HISTOCHEMISTRY AND CYTOCHEMISTRY

J. Dingle, A. Poole, 2005 .