K. Vandenbroeck

K. Vandenbroeck, M. Comabella, 2010, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

United Europeans for development of pharmacogenomics in multiple sclerosis network.

Alexander V. Favorov, P. Villoslada, J. Oksenberg, 2009, Pharmacogenomics.

Interleukin‐12 p40 polymorphism and susceptibility to multiple sclerosis

A. Goris, K. Vandenbroeck, I. Alloza, 2002, Annals of neurology.

Identi ﬁ cation of a functional variant in the KIF5A-CYP27B1-METTL1-FAM119B locus associated with multiple sclerosis

M. M. Abad-Grau, A. Alcina, F. Matesanz, 2012 .

IL28B polymorphisms are not associated with the response to interferon-beta in multiple sclerosis

X. Montalban, J. Lechner-Scott, E. Urcelay, 2011, Journal of Neuroimmunology.

Chitinase 3-like 1 plasma levels are increased in patients with progressive forms of multiple sclerosis

F. Matesanz, X. Montalban, F. Reverter, 2012, Multiple sclerosis.

Closing the case of APOE in multiple sclerosis: no association with disease risk in over 29 000 subjects

Isabelle Cournu-Rebeix, Frauke Zipp, Ulman Lindenberger, 2012, Journal of Medical Genetics.

Interferon gamma gene in rheumatoid arthritis

A. Goris, G. Opdenakker, K. Vandenbroeck, 2000, The Lancet.

Interferon‐γ gene polymorphism–associated risk for multiple sclerosis in sardinia

A. Goris, G. Opdenakker, K. Vandenbroeck, 1998, Annals of neurology.

Cholesterol Efflux Efficiency of Reconstituted HDL Is Affected by Nanoparticle Lipid Composition

K. Vandenbroeck, I. Alloza, César Martín, 2020, Biomedicines.

Celecoxib Inhibits Interleukin-12 (cid:1)(cid:2) and (cid:2) 2 Folding and Secretion by a Novel COX2-Independent Mechanism Involving Chaperones of the Endoplasmic Reticulum

K. Vandenbroeck, I. Alloza, R. Matthiesen, 2006 .

Cross-linking approach to affinity capture of protein complexes from chaotrope-solubilized cell lysates.

K. Vandenbroeck, I. Alloza, S. Hawthorne, 2004, Analytical biochemistry.

Refolding and single-step purification of porcine interferon-gamma from Escherichia coli inclusion bodies. Conditions for reconstitution of dimeric IFN-gamma.

K. Vandenbroeck, A. Billiau, E. Martens, 1993, European journal of biochemistry.

Pharmacogenomic study in patients with multiple sclerosis

X. Montalban, J. Lechner-Scott, A. Navarro, 2015, Neurology: Neuroimmunology & Neuroinflammation.

Tumor necrosis factor alpha and its receptors in relapsing-remitting multiple sclerosis.

A. Consiglio, M. Filippi, G. Comi, 1997, Journal of the neurological sciences.

Relevance of interleukin 1 receptor antagonist intron 2 polymorphism in Italian MS patients

V. Martinelli, G. Comi, M. Zaffaroni, 1999, Neurology.

A 4-trifluoromethyl analogue of celecoxib inhibits arthritis by suppressing innate immune cell activation

T. Yamamura, K. Vandenbroeck, I. Alloza, 2012, Arthritis Research & Therapy.

Pathophysiology of Atherosclerosis

K. Vandenbroeck, I. Alloza, César Martín, 2022, International journal of molecular sciences.

The endoplasmic reticulum protein folding factory and its chaperones: new targets for drug discovery?

K. Vandenbroeck, M. McLaughlin, 2011, British journal of pharmacology.

Engineering by PCR-based exon amplification of the genomic porcine interferon-gamma DNA for expression in Escherichia coli.

K. Vandenbroeck, R. Dijkmans, A. Van Aerschot, 1991, Biochemical and biophysical research communications.

Inhibiting cytokines of the interleukin‐12 family: recent advances and novel challenges

K. Vandenbroeck, I. Alloza, M. Gadina, 2004, The Journal of pharmacy and pharmacology.

Primitive endothelial cell lines from the porcine embryonic yolk sac

Johanna Plendl, Robert Auerbach, Shur-Jen Wang, 2002, In Vitro Cellular & Developmental Biology - Animal.

Genome-wide significant association with seven novel multiple sclerosis risk loci

A. Alcina, F. Matesanz, X. Montalban, 2015, Journal of Medical Genetics.

Human Endogenous Retrovirus HERV-Fc1 Association with Multiple Sclerosis Susceptibility: A Meta-Analysis

A. Alcina, F. Matesanz, E. Urcelay, 2014, PloS one.

Analysis of the IL28RA locus as genetic risk factor for multiple sclerosis

X. Montalban, E. Urcelay, K. Vandenbroeck, 2012, Journal of Neuroimmunology.

Linkage disequilibrium screening for multiple sclerosis implicates JAG1 and POU2AF1 as susceptibility genes in Europeans.

J. Ilonen, M. Ban, A. Goris, 2006 .

New candidate loci for multiple sclerosis susceptibility revealed by a whole genome association screen in a Belgian population

A. Goris, S. Sawcer, A. Compston, 2003, Journal of Neuroimmunology.

Polymorphisms in the interleukin‐4 and IL‐4 receptor genes and multiple sclerosis: a study in Spanish‐Basque, Northern Irish and Belgian populations

A. Goris, K. Vandenbroeck, I. Alloza, 2005, International journal of immunogenetics.

PECAM1, MPO and PRKAR1A at chromosome 17q21-q24 and susceptibility for multiple sclerosis in Sweden and Sardinia

T. Olsson, G. Opdenakker, K. Vandenbroeck, 2000, Journal of Neuroimmunology.

Analysis of an IFN-gamma gene (IFNG) polymorphism in multiple sclerosis in Europe: effect of population structure on association with disease.

A. Goris, T. Olsson, G. Opdenakker, 1999, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

Chromosome 7q21–22 and multiple sclerosis: evidence for a genetic susceptibility effect in vicinity to the protachykinin-1 gene

A. Goris, G. Opdenakker, K. Vandenbroeck, 2002, Journal of Neuroimmunology.

A genome wide scan for association with multiple sclerosis in a N. Irish case control population

S. Sawcer, A. Compston, M. Hutchinson, 2003, Journal of Neuroimmunology.

NLRP3 inflammasome as prognostic factor and therapeutic target in primary progressive multiple sclerosis patients.

F. Matesanz, J. Lünemann, X. Montalban, 2020, Brain : a journal of neurology.

The era of GWAS is over – Yes

K. Vandenbroeck, 2018, Multiple sclerosis.

Novel Transcript Discovery Expands the Repertoire of Pathologically-Associated, Long Non-Coding RNAs in Vascular Smooth Muscle Cells

I. Ulitsky, M. Ballantyne, K. Vandenbroeck, 2021, International journal of molecular sciences.

Boosting Cholesterol Efflux from Foam Cells by Sequential Administration of rHDL to Deliver MicroRNA and to Remove Cholesterol in a Triple-Cell 2D Atherosclerosis Model.

I. Santin, K. Vandenbroeck, I. Alloza, 2022, Small.

Lack of association between the interferon regulatory factor-1 (IRF1) locus at 5q31.1 and multiple sclerosis in Germany, Northern Italy, Sardinia and Sweden

T. Olsson, G. Opdenakker, K. Vandenbroeck, 2000, Genes and Immunity.

Gene sequence, cDNA construction, expression in Escherichia coli and genetically approached purification of porcine interleukin-1 beta.

A. Janssen, G. Opdenakker, K. Vandenbroeck, 1993, European journal of biochemistry.

Structural immuno-analysis of human and porcine interferon gamma: identification of shared antigenic domain.

K. Vandenbroeck, A. Billiau, T. Sareneva, 1997, Cytokine.

Cytokine gene polymorphisms and human autoimmune disease in the era of genome-wide association studies.

K. Vandenbroeck, 2012, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

ANKRD55 and DHCR7 are novel multiple sclerosis risk loci

A. Alcina, F. Matesanz, X. Montalban, 2011, Genes and Immunity.

Refining genetic associations in multiple sclerosis

Hanne F. Harbo, Margaret A. Pericak-Vance, Stephen L. Hauser, 2008, The Lancet Neurology.

Signalling, inflammation and arthritis

K. Vandenbroeck, M. Gadina, H. P. Carroll, 2008 .

Study of polymorphisms in the interleukin-4 and IL-4 receptor genes in a population of Brazilian patients with multiple sclerosis.

K. Vandenbroeck, S. Heggarty, T. Quirico-Santos, 2007, Arquivos de neuro-psiquiatria.

A New Risk Variant for Multiple Sclerosis at 11q23.3 Locus Is Associated with Expansion of CXCR5+ Circulating Regulatory T Cells

A. Alcina, F. Matesanz, X. Montalban, 2020, Journal of clinical medicine.

Interactome of the Autoimmune Risk Protein ANKRD55

Mikel Azkargorta, Felix Elortza, K. Vandenbroeck, 2019, Front. Immunol..

A role for autophagy in carotid atherosclerosis

K. Vandenbroeck, I. Alloza, Haize Goikuria, 2016, European stroke journal.

Response to interferon-beta treatment in multiple sclerosis patients: a genome-wide association study

X. Montalban, J. Lechner-Scott, M. Slee, 2016, The Pharmacogenomics Journal.

Signalling, inflammation and arthritis: crossed signals: the role of interleukin (IL)-12, -17, -23 and -27 in autoimmunity.

K. Vandenbroeck, M. Gadina, H. P. Carroll, 2008, Rheumatology.

Haplotype analysis of the preprotachykinin-1 (TAC1) gene in multiple sclerosis

K. Vandenbroeck, G. McDonnell, S. Hawkins, 2005, Genes and Immunity.

A functional variant that affects exon-skipping and protein expression of SP140 as genetic mechanism predisposing to multiple sclerosis.

María M. Abad-Grau, Víctor Potenciano, M. M. Abad-Grau, 2015, Human molecular genetics.

A cytokine gene screen uncovers SOCS1 as genetic risk factor for multiple sclerosis

A. Alcina, F. Matesanz, X. Montalban, 2011, Genes and Immunity.

Fine Mapping and Functional Analysis of the Multiple Sclerosis Risk Gene CD6

A. Alcina, F. Matesanz, J. Oksenberg, 2013, PloS one.

Validation of the CD6 and TNFRSF1A loci as risk factors for multiple sclerosis in Spain

A. Alcina, F. Matesanz, E. Urcelay, 2010, Journal of Neuroimmunology.

Allelic combinations of immune-response genes associated with glatiramer acetate treatment response in Russian multiple sclerosis patients.

Alexander V. Favorov, K. Vandenbroeck, O. Favorova, 2012, Pharmacogenomics.

Replication study of 10 genes showing evidence for association with multiple sclerosis: validation of TMEM39A, IL12B and CLBL genes

A. Alcina, F. Matesanz, X. Montalban, 2012, Multiple sclerosis.

High-resolution analysis of IL-6 minisatellite polymorphism in Sardinian multiple sclerosis: effect on course and onset of disease

A. Goris, G. Opdenakker, K. Vandenbroeck, 2000, Genes and Immunity.

Replication of top markers of a genome-wide association study in multiple sclerosis in Spain

A. Alcina, F. Matesanz, X. Montalban, 2011, Genes and Immunity.

Inhibition of Secretion of Interleukin (IL)-12/IL-23 Family Cytokines by 4-Trifluoromethyl-celecoxib Is Coupled to Degradation via the Endoplasmic Reticulum Stress Protein HERP*

K. Vandenbroeck, I. Alloza, C. Scott, 2010, The Journal of Biological Chemistry.

Irreversible inhibition of the bacterial cysteine protease-transpeptidase sortase (SrtA) by substrate-derived affinity labels.

K. Vandenbroeck, B. Walker, J. Lynas, 2002, The Biochemical journal.

Cell-specific effects in different immune subsets associated with SOCS1 genotypes in multiple sclerosis

X. Montalban, K. Vandenbroeck, I. Alloza, 2015, Multiple sclerosis.

Inflammation in human carotid atheroma plaques.

K. Vandenbroeck, I. Alloza, Haize Goikuria, 2018, Cytokine & growth factor reviews.

Two distinct interleukin-1β genes in the pig genome

G. Opdenakker, K. Vandenbroeck, A. Billiau, 2004, Immunogenetics.

Celecoxib Inhibits Interleukin-12 αβ and β2 Folding and Secretion by a Novel COX2-Independent Mechanism Involving Chaperones of the Endoplasmic Reticulum

K. Vandenbroeck, I. Alloza, R. Matthiesen, 2006, Molecular Pharmacology.

RNAseq based transcriptomics study of SMCs from carotid atherosclerotic plaque: BMP2 and IDs proteins are crucial regulators of plaque stability

K. Vandenbroeck, I. Alloza, R. Vega Manrique, 2017, Scientific Reports.

Novel Insights into the Multiple Sclerosis Risk Gene ANKRD55

X. Montalban, K. Vandenbroeck, I. Alloza, 2016, The Journal of Immunology.

Recombinant porcine IFN-gamma potentiates the secondary IgG and IgA responses to an inactivated suid herpesvirus-1 vaccine and reduces postchallenge weight loss and fever in pigs.

H. Nauwynck, K. Vandenbroeck, A. Billiau, 1998, Journal of Interferon and Cytokine Research.

The MHC2TA-168A/G and +1614G/C polymorphisms and risk for multiple sclerosis or chronic inflammatory arthropathies.

K. Vandenbroeck, S. Hawkins, C. O'Doherty, 2007, Tissue antigens.

The CTLA4 +49 A/G*G–CT60*G haplotype is associated with susceptibility to multiple sclerosis in Flanders

A. Goris, K. Vandenbroeck, I. Alloza, 2005, Journal of Neuroimmunology.

Polymorphism analysis suggests that the gelatinase B gene is not a susceptibility factor for multiple sclerosis

T. Olsson, G. Opdenakker, K. Vandenbroeck, 2000, Journal of Neuroimmunology.

Oxidative Stress and Proinflammatory Cytokines Contribute to Demyelination and Axonal Damage in a Cerebellar Culture Model of Neuroinflammation

Pablo Villoslada, P. Villoslada, K. Vandenbroeck, 2013, PloS one.

GroEL/ES chaperonins protect interferon-gamma against physicochemical stress--study of tertiary structure formation by alpha-casein quenching and ELISA.

K. Vandenbroeck, A. Billiau, E. Martens, 1998, European journal of biochemistry.

High affinity binding of hydrophobic and autoantigenic regions of proinsulin to the 70 kDa chaperone DnaK

Philipp Christen, H. Kolb, P. Christen, 2010, BMC Biochemistry.

A Trifluoromethyl Analogue of Celecoxib Exerts Beneficial Effects in Neuroinflammation

P. Villoslada, T. Yamamura, K. Vandenbroeck, 2013, PloS one.

IFN-beta pharmacogenomics in multiple sclerosis.

E. Urcelay, K. Vandenbroeck, M. Comabella, 2010, Pharmacogenomics.

MANBA , CXCR 5 , SOX 8 , RPS 6 KB 1 and ZBTB 46 are genetic risk loci for multiple sclerosis

Linda, Marcel, Winkelmann, 2013 .

Tumor necrosis factor α and its receptors in relapsing-remitting multiple sclerosis

A. Consiglio, M. Filippi, G. Comi, 1997, Journal of the Neurological Sciences.

Characterization of Carotid Smooth Muscle Cells during Phenotypic Transition

K. Vandenbroeck, I. Alloza, R. Vega Manrique, 2018, Cells.

Identification of a functional variant in the KIF5A-CYP27B1-METTL1-FAM119B locus associated with multiple sclerosis

María M. Abad-Grau, M. M. Abad-Grau, A. Alcina, 2012, Journal of Medical Genetics.

Allelic combinations of immune-response genes as possible composite markers of IFN-β efficacy in multiple sclerosis patients.

Alexander V. Favorov, K. Vandenbroeck, O. Favorova, 2012, Pharmacogenomics.

Genetic polymorphisms, their allele combinations and IFN-beta treatment response in Irish multiple sclerosis patients.

Alexander V. Favorov, M. Hutchinson, M. Ochs, 2009, Pharmacogenomics.

Pharmacogenomics of Type I interferon therapy: a survey of response-modifying genes.

P. Villoslada, K. Vandenbroeck, C. O'Doherty, 2007, Cytokine & growth factor reviews.

Linkage disequilibrium analysis of chromosome 12q14–15 in multiple sclerosis: delineation of a 118-kb interval around interferon-γ (IFNG) that is involved in male versus female differential susceptibility

A. Goris, K. Vandenbroeck, S. Heggarty, 2002, Genes and Immunity.

Genome-wide significant association of ANKRD55 rs6859219 and multiple sclerosis risk

Shu-Chen Li, A. Alcina, F. Matesanz, 2013, Journal of Medical Genetics.

The neuropeptide genes TAC1, TAC3, TAC4, VIP and PACAP(ADCYAP1), and susceptibility to multiple sclerosis

K. Vandenbroeck, C. Patterson, G. McDonnell, 2007, Journal of Neuroimmunology.

Occurrence and clinical relevance of an interleukin-4 gene polymorphism in patients with multiple sclerosis

A. Consiglio, G. Comi, L. Grimaldi, 1997, Journal of Neuroimmunology.

Autophagic Marker MAP1LC3B Expression Levels Are Associated with Carotid Atherosclerosis Symptomatology

K. Vandenbroeck, I. Alloza, B. Swaminathan, 2014, PloS one.

Validation of IRF5 as multiple sclerosis risk gene: putative role in interferon beta therapy and human herpes virus-6 infection

E. Urcelay, K. Vandenbroeck, I. Alloza, 2011, Genes and Immunity.

IL7RA polymorphisms and susceptibility to multiple sclerosis.

K. Vandenbroeck, O. Kantarci, C. O'Doherty, 2008, The New England journal of medicine.

CTLA4 gene polymorphisms and multiple sclerosis in Northern Ireland

K. Vandenbroeck, S. Heggarty, G. McDonnell, 2007, Journal of Neuroimmunology.

ITGA4 polymorphisms and susceptibility to multiple sclerosis

K. Vandenbroeck, A. Aransay, J. Hillert, 2007, Journal of Neuroimmunology.

Novel polymorphisms in the IL-10 related AK155 gene (chromosome 12q15)

A. Goris, K. Vandenbroeck, M. Marrosu, 2001, Genes and Immunity.

Cytokine gene polymorphisms in multifactorial diseases: gateways to novel targets for immunotherapy?

A. Goris, K. Vandenbroeck, 2003, Trends in pharmacological sciences.

Genomic Multiple Sclerosis Risk Variants Modulate the Expression of the ANKRD55–IL6ST Gene Region in Immature Dendritic Cells

C. Lindskog, X. Montalban, K. Vandenbroeck, 2022, Frontiers in Immunology.

Occurence and clinical relevance of an interleukin-4 gene polymorphism im patients with multiple sclerosis

A. Consiglio, L. Grimaldi, M. Zaffaroni, 1997 .

Multi-chaperone complexes regulate the folding of interferon-gamma in the endoplasmic reticulum.

K. Vandenbroeck, I. Alloza, E. Martens, 2006, Cytokine.

A Dinucleotide Repeat Polymorphism Located in the IFN-α/β Gene Cluster at Chromosome 9p22 Is Not Associated with Multiple Sclerosis in Sardinia

A. Goris, G. Opdenakker, K. Vandenbroeck, 1999, Experimental and Clinical Immunogenetics.

Pharmacogenomics of the response to IFN-beta in multiple sclerosis: ramifications from the first genome-wide screen.

K. Vandenbroeck, C. Matute, 2008, Pharmacogenomics.

Protein disulfide isomerase-mediated cell-free assembly of recombinant interleukin-12 p40 homodimers.

K. Vandenbroeck, I. Alloza, A. Billiau, 2000, European journal of biochemistry.

Pharmacogenomics and Multiple Sclerosis: Moving Toward Individualized Medicine

K. Vandenbroeck, M. Comabella, 2011, Current neurology and neuroscience reports.

Validation of the CD6 and TNFRSF1A loci as risk factors for multiple sclerosis in Spain

A. Alcina, F. Matesanz, E. Urcelay, 2010, Journal of Neuroimmunology.