D. Brehmer

发表

The Conserved Helix C Region in the Superfamily of Interferon-γ/Interleukin-10-related Cytokines Corresponds to a High-affinity Binding Site for the HSP70 Chaperone DnaK*

N. Mcferran, S. Rüdiger, K. Vandenbroeck, 2002, The Journal of Biological Chemistry.

Quantitative Phosphoproteomics Analysis of ERBB3/ERBB4 Signaling

E. Jacoby, N. Jordan, D. Brehmer, 2016, PloS one.

Structural investigation of B-Raf paradox breaker and inducer inhibitors.

Lennart Martens, Edgar Jacoby, Kris Gevaert, 2015, Journal of medicinal chemistry.

Limited Proteolysis Combined with Stable Isotope Labeling Reveals Conformational Changes in Protein (Pseudo)kinases upon Binding Small Molecules.

E. Jacoby, R. Zubarev, K. Gevaert, 2015, Journal of proteome research.

Tuning of chaperone activity of Hsp70 proteins by modulation of nucleotide exchange

Lars Packschies, Dagmar Klostermeier, Bernd Bukau, 2001, Nature Structural Biology.

Influence of GrpE on DnaK-Substrate Interactions*

M. Mayer, B. Bukau, D. Brehmer, 2004, Journal of Biological Chemistry.

Bag-1M Accelerates Nucleotide Release for Human Hsc70 and Hsp70 and Can Act Concentration-dependent as Positive and Negative Cofactor*

M. Mayer, B. Bukau, D. Brehmer, 2001, The Journal of Biological Chemistry.

Abstract DDT02-04: A novel PRMT5 inhibitor with potent in vitro and in vivo activity in preclinical lung cancer models

Italo Poggesi, Vineet Pande, James P. Edwards, 2017 .

Maternal embryonic leucine zipper kinase (MELK) reduces replication stress in glioblastoma cells.

M. Bollen, D. Brehmer, M. Beullens, 2013, The Journal of Biological Chemistry.

Microsoft Word-01062013 manuscript2

M. Bollen, D. Brehmer, M. Beullens, 2013 .

PepShell: visualization of conformational proteomics data.

E. Jacoby, K. Gevaert, D. Brehmer, 2015, Journal of proteome research.

A Chemical Probe for the Methyl Transferase PRMT5 with a Novel Binding Mode.

V. Pande, D. Brehmer, M. Paradé, 2020, ACS medicinal chemistry letters.

Fragment-based discovery of type I inhibitors of maternal embryonic leucine zipper kinase.

F. Sommen, A. Sharff, V. Berdini, 2015, ACS medicinal chemistry letters.

Discovery and Pharmacological Characterization of JNJ-64619178, a Novel Small-Molecule Inhibitor of PRMT5 with Potent Antitumor Activity

Bie M. P. Verbist, U. Philippar, T. Graubert, 2021, Molecular Cancer Therapeutics.

Chemical Proteomic Analysis Reveals Alternative Modes of Action for Pyrido[2,3-d]pyrimidine Kinase Inhibitors*

M. Cotten, D. Brehmer, H. Daub, 2004, Molecular & Cellular Proteomics.

Hsp70 chaperone machines.

M. Mayer, B. Bukau, D. Brehmer, 2001, Advances in protein chemistry.

Structure-Function Analysis of HscC, theEscherichia coli Member of a Novel Subfamily of Specialized Hsp70 Chaperones*

J. Schneider-Mergener, H. Patzelt, M. Mayer, 2002, The Journal of Biological Chemistry.

CD74-NRG1 fusions in lung adenocarcinoma.

I. Petersen, S. Haas, M. Vingron, 2014, Cancer discovery.

Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor

P. Zarrinkar, K. Yu, D. Brehmer, 2018, Cell.

Cellular targets of gefitinib.

György Kéri, G. Kéri, M. Cotten, 2005, Cancer research.

Evaluation of kinase inhibitor selectivity by chemical proteomics.

G. Müller, D. Brehmer, H. Daub, 2004, Assay and drug development technologies.

Structure-Based Design of Type II Inhibitors Applied to Maternal Embryonic Leucine Zipper Kinase.

V. Berdini, D. Brehmer, J. Linders, 2015, ACS medicinal chemistry letters.

Proteome-wide Identification of Cellular Targets Affected by Bisindolylmaleimide-type Protein Kinase C Inhibitors*

D. Brehmer, H. Daub, J. Wissing, 2004, Molecular & Cellular Proteomics.

Binding specificity of Escherichia coli trigger factor

J. Schneider-Mergener, H. Patzelt, S. Rüdiger, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Maternal Embryonic Leucine Zipper Kinase (MELK) Reduces Replication Stress in Glioblastoma Cells*

M. Bollen, D. Brehmer, M. Beullens, 2013, The Journal of Biological Chemistry.

Analysis of the quality of wood and charcoal produced from the species Miconia cinnamomifolia (De Candolle) Naudin (Jacatirão-açu) in family farming, in Biguaçu, Santa Catarina, Brazil.

D. Brehmer, M. Brand, A. B. D. Cunha, 2013 .

Particleboard manufacture from Eucalyptus benthamii, Eucalyptus dunnii and Eucalyptus grandis.

D. Brehmer, A. B. D. Cunha, A. Rodrigues, 2014 .

MELK-T1, a small-molecule inhibitor of protein kinase MELK, decreases DNA-damage tolerance in proliferating cancer cells

M. Bollen, D. Brehmer, M. Paradé, 2015, Bioscience reports.

Design, synthesis and characterisation of a novel type II B-RAF paradox breaker inhibitor.

S. Knapp, D. Brehmer, J. Linders, 2023, European journal of medicinal chemistry.

Proteomic characterization of the angiogenesis inhibitor SU6668 reveals multiple impacts on cellular kinase signaling.

A. Ullrich, G. Kéri, M. Cotten, 2005, Cancer research.

JNJ-26854165 - a novel hdm2 antagonist in clinical development showing broad-spectrum preclinical antitumor activity against solid malignancies

C. Blattner, M. Janicot, P. Verhasselt, 2008 .