J. Rini

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Trimeric HIV-1 gp140 fused with APRIL, BAFF, and CD40L on the mucosal gp140-specific antibody responses in mice.

M. Ostrowski, Jun Liu, K. Clayton, 2020, Vaccine.

Major antigen-induced domain rearrangements in an antibody.

R L Stanfield, I. Wilson, R. Stanfield, 1993, Structure.

The X-ray Crystal Structure of Human Aminopeptidase N Reveals a Novel Dimer and the Basis for Peptide Processing*

J. Rini, A. Wong, Dongxia Zhou, 2012, The Journal of Biological Chemistry.

New animal lectin structures.

J. Rini, Y. Lobsanov, 1999, Current opinion in structural biology.

Comparative evaluation of two severe acute respiratory syndrome (SARS) vaccine candidates in mice challenged with SARS coronavirus.

R. Brunham, B. Finlay, D. Skowronski, 2006, The Journal of general virology.

Structural basis of calcium-induced E-cadherin rigidification and dimerization

Mitsuhiko Ikura, M. Ikura, M. Overduin, 1996 .

Detection and Neutralization of SARS-CoV-2 Using Non-conventional Variable Lymphocyte Receptor Antibodies of the Evolutionarily Distant Sea Lamprey

M. Ostrowski, P. Budylowski, J. Rini, 2021, Frontiers in Immunology.

A homogeneous split-luciferase assay for rapid and sensitive detection of anti-SARS CoV-2 antibodies

M. Drebot, M. Ostrowski, J. Snider, 2021, Nature communications.

Enhancing the performance of paper-based electrochemical impedance spectroscopy nanobiosensors: An experimental approach

R. Peng, J. Rini, Xiao Li, 2020, Biosensors and Bioelectronics.

Axonal Transport Enables Neuron-to-Neuron Propagation of Human Coronavirus OC43

J. Rini, Alain Le Coupanec, M. Desforges, 2018, Journal of Virology.

Glycosyltransferases and Glycan-processing Enzymes

A. Varki, J. Esko, J. Rini, 2009 .

X-ray crystal structure of the human galectin-3 carbohydrate recognition domain at 2.1-A resolution.

S. Barondes, J. Seetharaman, J. Rini, 1998, The Journal of biological chemistry.

Neutralizing epitopes of the SARS-CoV S-protein cluster independent of repertoire, antigen structure or mAb technology

F. Plummer, J. Rini, C. Corbett, 2010, mAbs.

CRYSTAL STRUCTURE OF AN HIV-1 NEUTRALIZING ANTIBODY 50.1 IN COMPLEX WITH ITS V3 LOOP PEPTIDE ANTIGEN

I. Wilson, R. Stanfield, J. Rini, 1993 .

A homogeneous split-luciferase assay for rapid and sensitive detection of anti-SARS CoV-2 antibodies

M. Drebot, M. Ostrowski, J. Snider, 2020, Nature Communications.

Title: Mucosal versus systemic antibody responses to SARS-CoV-2 antigens in COVID-19 patients

A. Gingras, J. Wrana, K. Colwill, 2020 .

SARS-CoV-2–Reactive Mucosal B Cells in the Upper Respiratory Tract of Uninfected Individuals

M. Ostrowski, P. Budylowski, J. Rini, 2021, The Journal of Immunology.

The use of SnB to determine an anomalous scattering substructure.

H. Hauptman, B. Nagar, J. Rini, 1998, Acta crystallographica. Section D, Biological crystallography.

Crystallization and preliminary X-ray diffraction analysis of the human dimeric S-Lac lectin (L-14-II).

S. Barondes, J. Rini, Y. Lobsanov, 1993, Journal of molecular biology.

Systemic and mucosal IgA responses are variably induced in response to SARS-CoV-2 mRNA vaccination and are associated with protection against subsequent infection

I. Weissman, A. Gingras, K. Colwill, 2022, Mucosal Immunology.

Detection of SARS-CoV-2 Viral Particles Using Direct, Reagent-Free Electrochemical Sensing

S. Kelley, E. Sargent, J. Rini, 2020, Journal of the American Chemical Society.

Synthetic antibodies neutralize SARS-CoV-2 infection of mammalian cells

P. Pandolfi, M. Diamond, M. Capobianchi, 2020, bioRxiv.

Persistence of T Cell and Antibody Responses to SARS-CoV-2 Up to 9 Months after Symptom Onset

A. Gingras, K. Colwill, M. Ostrowski, 2021, The Journal of Immunology.

Immunity to SARS-CoV-2 persists 9 months post-symptoms with an altered T cell phenotype compared to influenza A virus-specific memory

A. Gingras, K. Colwill, M. Ostrowski, 2021, medRxiv.

Exploiting the diphtheria toxin internalization receptor enhances delivery of proteins to lysosomes for enzyme replacement therapy

J. Rini, P. Kim, B. Minassian, 2020, Science Advances.

Carbohydrates and glycoconjugates.

J. Rini, K. Drickamer, 1995, Current opinion in structural biology.

FASN inhibitor TVB-3166 prevents S-acylation of the spike protein of human coronaviruses

B. Raught, G. Fairn, J. Rini, 2022, bioRxiv.

A mucosal antibody response is induced by intra-muscular SARS-CoV-2 mRNA vaccination

I. Weissman, A. Gingras, K. Colwill, 2021, medRxiv.

Exploiting toxin internalization receptors to enhance delivery of proteins to lysosomes for enzyme replacement therapy

J. Rini, P. Kim, B. Minassian, 2020, bioRxiv.

Simple piggyBac transposon-based mammalian cell expression system for inducible protein production

A. Nagy, J. Rini, Zhijie Li, 2013, Proceedings of the National Academy of Sciences.

X-ray crystal structures of animal lectins.

J. Rini, 1995, Current opinion in structural biology.

Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection

R. Kaul, A. Jha, D. Nixon, 2008, The Journal of experimental medicine.

X-ray crystal structure of C3d: a C3 fragment and ligand for complement receptor 2.

B. Nagar, J. Rini, R. Diefenbach, 1998, Science.

Tetravalent SARS-CoV-2 Neutralizing Antibodies Show Enhanced Potency and Resistance to Escape Mutations

P. Pandolfi, M. Diamond, J. Gupta, 2020, bioRxiv.

X-ray crystal structures of rabbit N-acetylglucosaminyltransferase I (GnT I) in complex with donor substrate analogues.

S. Withers, J. Rini, P. Sivarajah, 2006, Journal of molecular biology.

Glycosyltransferase structure and mechanism.

J. Rini, J M Rini, U M Unligil, 2000, Current opinion in structural biology.

Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens in patients with COVID-19

A. Gingras, J. Wrana, K. Colwill, 2021 .

Systematic Examination of Antigen-Specific Recall T Cell Responses to SARS-CoV-2 versus Influenza Virus Reveals a Distinct Inflammatory Profile.

A. Gingras, P. Budylowski, F. Yue, 2020, Journal of immunology.

Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens in COVID-19 patients

A. Gingras, J. Wrana, K. Colwill, 2020, Science Immunology.

Systematic examination of T cell responses to SARS-CoV-2 versus influenza virus reveals distinct inflammatory profile

A. Gingras, M. Ostrowski, P. Budylowski, 2020, medRxiv.

Evidence for sustained mucosal and systemic antibody responses to SARS-CoV-2 antigens in COVID-19 patients

A. Gingras, J. Wrana, K. Colwill, 2020, medRxiv.

Structural basis of calcium-induced E-cadherin rigidification and dimerization

M. Ikura, M. Overduin, B. Nagar, 1996, Nature.

Galectins: A family of animal β-galactoside-binding lectins

Richard D. Cummings, Jun Hirabayashi, Reuben Lotan, 1994, Cell.

A simple protein-based surrogate neutralization assay for SARS-CoV-2

A. Gingras, M. Drebot, K. Colwill, 2020, bioRxiv.

X-ray Crystal Structure of the Human Galectin-3 Carbohydrate Recognition Domain at 2.1-Å Resolution*

S. Barondes, J. Seetharaman, J. Rini, 1998, The Journal of Biological Chemistry.

Structural and mechanistic characterization of leukocyte-type core 2 β1,6-N-acetylglucosaminyltransferase: a metal-ion-independent GT-A glycosyltransferase.

J. Seetharaman, J. Rini, M. Satkunarajah, 2011, Journal of molecular biology.

X‐ray crystal structure of rabbit N‐acetylglucosaminyltransferase I: catalytic mechanism and a new protein superfamily

J. Rini, H. Schachter, Harry Schachter, 2000, The EMBO journal.

X-ray crystal structure determination of mammalian glycosyltransferases.

J. Rini, J. Pak, 2006, Methods in enzymology.

Independent Lec1A CHO glycosylation mutants arise from point mutations in N-acetylglucosaminyltransferase I that reduce affinity for both substrates. Molecular consequences based on the crystal structure of GlcNAc-TI.

P. Stanley, J. Rini, W. Chen, 2001, Biochemistry.

Monovalent interactions of galectin-1.

J. Rini, Hanna A. Rydberg, Y. Lobsanov, 2010, Biochemistry.

Rapid and facile recombinant expression of bovine rhodopsin in HEK293S GnTI(-) cells using a PiggyBac inducible system.

J. Rini, O. Ernst, Zhijie Li, 2015, Methods in enzymology.

X-ray crystal structure of leukocyte type core 2 beta1,6-N-acetylglucosaminyltransferase. Evidence for a convergence of metal ion-independent glycosyltransferase mechanism.

Xuekun Xing, J. Rini, P. Arnoux, 2006, The Journal of biological chemistry.

Lectin structure.

J. Rini, J M Rini, 1995, Annual review of biophysics and biomolecular structure.

X-ray crystal structure of the human dimeric S-Lac lectin, L-14-II, in complex with lactose at 2.9-A resolution.

S. Barondes, J. Rini, Y. Lobsanov, 1994, The Journal of biological chemistry.

X-ray crystal structure of a pea lectin-trimannoside complex at 2.6 A resolution.

F. L. Suddath, K. D. Hardman, J. Rini, 1993, The Journal of biological chemistry.

Recognition of EGF-like domains by the Notch-modifying O-fucosyltransferase POFUT1.

J. Rini, Zhijie Li, Dongxia Zhou, 2017, Nature chemical biology.

Structural basis of Notch O-glucosylation and O–xylosylation by mammalian protein–O-glucosyltransferase 1 (POGLUT1)

S. Withers, J. Rini, Zhijie Li, 2017, Nature Communications.

Local acting Sticky-trap inhibits vascular endothelial growth factor dependent pathological angiogenesis in the eye

D. van der Kooy, A. Nagy, M. Iruela-Arispe, 2014, EMBO molecular medicine.

Convergent CDR3 homology amongst Spike-specific antibody responses in convalescent COVID-19 subjects receiving the BNT162b2 vaccine

M. Ostrowski, F. Yue, J. Rini, 2022, Clinical Immunology.

The ZIP5 Ectodomain Co-Localizes with PrP and May Acquire a PrP-Like Fold That Assembles into a Dimer

L. Kay, C. Arrowsmith, A. Yee, 2013, PloS one.

Structural and thermodynamic studies on cation-Pi interactions in lectin-ligand complexes: high-affinity galectin-3 inhibitors through fine-tuning of an arginine-arene interaction.

J. Rini, P. Arnoux, Hakon Leffler, 2005, Journal of the American Chemical Society.

Mutational Tuning of Galectin-3 Specificity and Biological Function

J. Rini, A. Karlsson, Ruth Hendus-Altenburger, 2010, The Journal of Biological Chemistry.

Receptor-binding loops in alphacoronavirus adaptation and evolution

J. Rini, M. Desforges, P. Talbot, 2017, Nature Communications.

The human coronavirus HCoV-229E S-protein structure and receptor binding

John L Rubinstein, Samir Benlekbir, J. Rubinstein, 2019, eLife.

Structural Insights into Immune Recognition of the Severe Acute Respiratory Syndrome Coronavirus S Protein Receptor Binding Domain

F. Plummer, J. Seetharaman, J. Rini, 2009, Journal of Molecular Biology.

Immunogenicity of a receptor-binding domain of SARS coronavirus spike protein in mice: Implications for a subunit vaccine

Chetna Sharon, Robert C. Brunham, Lorne A. Babiuk, 2006, Vaccine.

Re-examining the proposed lectin properties of IL-2.

J. Rini, Giuseppe A. Papalia, 2008, Molecular immunology.

Structural evidence for induced fit as a mechanism for antibody-antigen recognition.

I. Wilson, J. Rini, U. Schulze-Gahmen, 1994, Science.

Expansion of Dysfunctional Tim-3–Expressing Effector Memory CD8+ T Cells during Simian Immunodeficiency Virus Infection in Rhesus Macaques

M. Ostrowski, M. Kuroda, S. Hansen, 2014, The Journal of Immunology.

Tetravalent SARS-CoV-2 Neutralizing Antibodies Show Enhanced Potency and Resistance to Escape Mutations

P. Pandolfi, M. Diamond, J. Gupta, 2020, bioRxiv.

Intranasal HD-Ad vaccine protects the upper and lower respiratory tracts of hACE2 mice against SARS-CoV-2

J. Rini, S. Gray-Owen, S. Mubareka, 2021, bioRxiv.

N-glycans are direct determinants of CFTR folding and stability in secretory and endocytic membrane traffic

G. Lukács, J. Rini, T. Okiyoneda, 2009, The Journal of cell biology.

Pandemic H1N1 Influenza Infection and Vaccination in Humans Induces Cross-Protective Antibodies that Target the Hemagglutinin Stem

J. W. Schrader, V. G. Allen, W. Wang, 2012, Front. Immun..

X-ray crystallographic analysis of free and antigen-complexed Fab fragments to investigate structural basis of immune recognition.

I. Wilson, J. Rini, E. Stura, 1991, Methods in enzymology.

Structural aspects of antibodies and antibody-antigen complexes.

D. Fremont, I. Wilson, R. Stanfield, 2007, Ciba Foundation symposium.

Preliminary crystallographic data, primary sequence, and binding data for an anti-peptide Fab and its complex with a synthetic peptide from influenza virus hemagglutinin.

I. Wilson, J. Kenten, J. Rini, 1988, The Journal of biological chemistry.

SPEEDS: A portable serological testing platform for rapid electrochemical detection of SARS-CoV-2 antibodies

Xin Liu, J. Rini, Zhijie Li, 2021, Biosensors and Bioelectronics.

Crystal structure of a human immunodeficiency virus type 1 neutralizing antibody, 50.1, in complex with its V3 loop peptide antigen.

R L Stanfield, I. Wilson, R. Stanfield, 1993, Proceedings of the National Academy of Sciences of the United States of America.

The recombinant globular head domain of the measles virus hemagglutinin protein as a subunit vaccine against measles.

J. Rini, A. Zakhartchouk, G. Mutwiri, 2012, Vaccine.

X-ray crystal structure of a galactose-specific C-type lectin possessing a novel decameric quaternary structure.

B. Nagar, J. Rini, J. Walker, 2004, Biochemistry.

Carbohydrate Recognition and Signaling

J. Rini, H. Leffler, 2010 .

CHAPTER 15 – Carbohydrate Recognition and Signaling

J. Rini, H. Leffler, 2003 .

A simple protein-based SARS-CoV-2 surrogate neutralization assay

A. Gingras, M. Drebot, K. Colwill, 2020 .

8 – Structural Studies of Antipeptide Antibodies

I. Wilson, R. Stanfield, J. Rini, 1990 .

Detailed analysis of the free and bound conformations of an antibody. X-ray structures of Fab 17/9 and three different Fab-peptide complexes.

I. Wilson, J. Rini, U. Schulze-Gahmen, 1993, Journal of molecular biology.

Crystallization and preliminary X-ray diffraction studies of a pea lectin-methyl 3,6-di-O-(α-d-mannopyranosyl)-α-d-mannopyranoside complex

K. D. Hardman, J. Rini, J. Carver, 1986 .