J. Grimes

发表

High-resolution crystal structure of arthropod Eiger TNF suggests a mode of receptor engagement and altered surface charge within endosomes

M. Bertinelli, G. Paesen, J. Grimes, 2019, Communications Biology.

Structure and Self-Assembly of the Calcium Binding Matrix Protein of Human Metapneumovirus

J. Grimes, M. Renner, J. Huiskonen, 2014, Structure.

Structural Insights into the Human Metapneumovirus Glycoprotein Ectodomain

G. Paesen, J. Grimes, M. Renner, 2014, Journal of Virology.

Solution and Crystallographic Structures of the Central Region of the Phosphoprotein from Human Metapneumovirus

J. Grimes, M. Renner, K. Harlos, 2013, PloS one.

The structure and function of the outer coat protein VP9 of Banna virus.

D. Stuart, X. de Lamballerie, P. de Micco, 2005, Structure.

Where is crystallography going?

F. von Delft, J. Grimes, K. McAuley, 2018, Acta crystallographica. Section D, Structural biology.

In situ macromolecular crystallography using microbeams

Gwyndaf Evans, Jun Aishima, David I. Stuart, 2012, Acta crystallographica. Section D, Biological crystallography.

Mass Spectrometry – Based Proteomics and Network Biology

Robert V Farese, D. Stuart, J. Cooper, 2013 .

Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19

P. Sopp, D. Stuart, P. Klenerman, 2020, Nature Immunology.

The atomic structure of the bluetongue virus core

D. Stuart, J. Burroughs, J. Grimes, 1998, Nature.

The Highly Ordered Double-Stranded RNA Genome of Bluetongue Virus Revealed by Crystallography

D. Stuart, J. Burroughs, J. Grimes, 1999, Cell.

Translocation portals for the substrates and products of a viral transcription complex: the bluetongue virus core

D. Stuart, J. Burroughs, J. Grimes, 2001, The EMBO journal.

Human Metapneumovirus Matrix Protein

J. Grimes, M. Renner, C. Leyrat, 2015 .

Germline mutations in the proof-reading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas

Peter Donnelly, Jonathan Grimes, Gilean McVean, 2012, Nature Genetics.

Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas

Peter Donnelly, Jonathan Grimes, Gilean McVean, 2013, Nature Genetics.

The nsp9 Replicase Protein of SARS-Coronavirus, Structure and Functional Insights

David I Stuart, David Alderton, Lester G. Carter, 2004, Structure.

Expression, purification and crystallization of a lyssavirus matrix (M) protein.

Olivier Delmas, David I Stuart, Raymond J Owens, 2008, Acta crystallographica. Section F, Structural biology and crystallization communications.

Crystal Structure of a Novel Conformational State of the Flavivirus NS3 Protein: Implications for Polyprotein Processing and Viral Replication

E. Mancini, R. Owens, D. Stuart, 2009, Journal of Virology.

Structure of the Murray Valley encephalitis virus RNA helicase at 1.9 Å resolution

E. Mancini, R. Owens, D. Stuart, 2007 .

Structure of the Murray Valley encephalitis virus RNA helicase at 1.9 Angstrom resolution.

E. Mancini, R. Owens, D. Stuart, 2007, Protein science : a publication of the Protein Society.

Selenomethionine labeling of large biological macromolecular complexes: probing the structure of marine bacterial virus PM2.

D. Stuart, N. Abrescia, J. Grimes, 2008, Journal of structural biology.

Gene silencing pathway RNA-dependent RNA polymerase of Neurospora crassa: yeast expression and crystallization of selenomethionated QDE-1 protein.

D. Stuart, J. Grimes, D. Bamford, 2005, Journal of structural biology.

A high resolution view of an adolescent flavivirus

G. Screaton, J. Grimes, M. Renner, 2020, bioRxiv.

Unexpected structure for the N-terminal domain of hepatitis C virus envelope glycoprotein E1

D. Stuart, J. Grimes, K. Harlos, 2014, Nature communications.

Expression, purification and crystallization of the ectodomain of the envelope glycoprotein E2 from Bovine viral diarrhoea virus.

C. Meier, D. Stuart, Weixian Lu, 2013, Acta crystallographica. Section F, Structural biology and crystallization communications.

Unusual Molecular Architecture of the Machupo Virus Attachment Glycoprotein

D. Stuart, J. Grimes, E. Jones, 2009, Journal of Virology.

Structural basis of Nipah and Hendra virus attachment to their cell-surface receptor ephrin-B2

David I Stuart, Thomas A Bowden, D. Stuart, 2008, Nature Structural &Molecular Biology.

Mapping the IκB Kinase β (IKKβ)-binding Interface of the B14 Protein, a Vaccinia Virus Inhibitor of IKKβ-mediated Activation of Nuclear Factor κB

D. Stuart, J. Grimes, Geoffrey L. Smith, 2011, The Journal of Biological Chemistry.

Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent COVID-19 patients

P. Sopp, D. Stuart, P. Klenerman, 2020, bioRxiv.

Membrane structure and interactions with protein and DNA in bacteriophage PRD1

D. Stuart, N. Abrescia, J. Grimes, 2004, Nature.

Crystallization of the membrane-containing bacteriophage PRD1 in quartz capillaries by vapour diffusion.

D. Stuart, J. Grimes, D. Bamford, 2003, Acta crystallographica. Section D, Biological crystallography.

The structure of a prokaryotic viral envelope protein expands the landscape of membrane fusion proteins

D. Stuart, D. Clare, F. De Haas, 2019, Nature Communications.

More powerful virus inhibitors from structure-based analysis of HEV71 capsid-binding molecules

D. Stuart, D. Rowlands, Z. Rao, 2014, Nature Structural &Molecular Biology.

Implications of the HIV-1 Rev dimer structure at 3.2 Å resolution for multimeric binding to the Rev response element

D. Stuart, P. Wingfield, S. Stahl, 2010, Proceedings of the National Academy of Sciences.

Complete sequence of Great Island virus and comparison with the T2 and outer-capsid proteins of Kemerovo, Lipovnik and Tribec viruses (genus Orbivirus, family Reoviridae).

R. Tesh, J. Grimes, F. Mohd Jaafar, 2010, The Journal of general virology.

Structure of a VP1-VP3 Complex Suggests How Birnaviruses Package the VP1 Polymerase

D. Stuart, J. Grimes, D. Bamford, 2013, Journal of Virology.

Antigenic switching of hepatitis B virus by alternative dimerization of the capsid protein.

D. Stuart, P. Wingfield, S. Stahl, 2013, Structure.

Crystal Structure of a Novel Conformational State of the Flavivirus NS3 Protein: Implications for Polyprotein Processing and Viral Replication (cid:1)

E. Mancini, R. Owens, D. Stuart, 2009 .

Influenza A virus RNA polymerase structures provide insights into viral genome replication

E. Pardon, J. Steyaert, J. Grimes, 2019, Nature.

Bluetongue virus VP4 is an RNA-capping assembly line

D. Stuart, J. Grimes, P. Roy, 2007, Nature Structural &Molecular Biology.

Structure of the integrin binding fragment from fibrillin-1 gives new insights into microfibril organization.

D. Stuart, P. Handford, J. Grimes, 2004, Structure.

Mycobacterium tuberculosis CarD, an essential global transcriptional regulator forms amyloid-like fibrils

J. Grimes, J. Huiskonen, Soni Kaundal, 2018, Scientific Reports.

Preliminary crystallographic analysis of the major capsid protein P2 of the lipid-containing bacteriophage PM2.

D. Stuart, N. Abrescia, J. Grimes, 2005, Acta crystallographica. Section F, Structural biology and crystallization communications.

Structural studies of orbivirus particles.

D. Stuart, J. Burroughs, J. Grimes, 1998, Archives of virology. Supplementum.

The matrix protein of rabies virus binds to RelAp43 to modulate NF-κB-dependent gene expression related to innate immunity

J. Grimes, H. Bourhy, F. Larrous, 2016, Scientific Reports.

Structure of CPV17 polyhedrin determined by the improved analysis of serial femtosecond crystallographic data

D. Stuart, M. Messerschmidt, J. Grimes, 2015, Nature Communications.

3D Correlative Cryo-Structured Illumination Fluorescence and Soft X-ray Microscopy Elucidates Reovirus Intracellular Release Pathway

P. Paul-Gilloteaux, I. Dobbie, J. Grimes, 2020, Cell.

Correlative cryo-structured illumination fluorescence microscopy and soft X-ray tomography elucidates reovirus intracellular release pathway

P. Paul-Gilloteaux, I. Dobbie, J. Grimes, 2020, bioRxiv.

An in cellulo-derived structure of PAK4 in complex with its inhibitor Inka1

W. L. Chan, R. Robinson, J. Grimes, 2015, Nature Communications.

Influenza A virus RNA polymerase structures provide insights into viral genome replication

E. Pardon, J. Steyaert, J. Grimes, 2019, Nature.

The C-terminal LCAR of host ANP32 proteins interacts with the influenza A virus nucleoprotein to promote the replication of the viral RNA genome

J. Grimes, E. Fodor, E. Staller, 2022, Nucleic acids research.

An In-Depth Analysis of Original Antigenic Sin in Dengue Virus Infection

C. Midgley, G. Screaton, S. Yoksan, 2011, Journal of Virology.

The SARS-CoV-2 RNA polymerase is a viral RNA capping enzyme

J. Grimes, J. Keown, E. Fodor, 2021, Nucleic acids research.

Identification of guanylyltransferase activity in the SARS-CoV-2 RNA polymerase

J. Grimes, J. Keown, E. Fodor, 2021, bioRxiv.

A new class of highly potent, broadly neutralizing antibodies isolated from viremic patients infected with dengue virus

Cameron P Simmons, Prida Malasit, J. Farrar, 2014, Nature Immunology.

An In-Depth Analysis of Original Antigenic Sin in Dengue Virus Infection

Cameron P. Simmons, Sutee Yoksan, Prida Malasit, 2010, Journal of Virology.

The Structure of an RNAi Polymerase Links RNA Silencing and Transcription

David I Stuart, D. Stuart, J. Grimes, 2006, PLoS biology.

Nature author index

J. Grimes, J. Bamford, G. Fontaine, 2003 .

Structure of a Pestivirus Envelope Glycoprotein E2 Clarifies Its Role in Cell Entry

D. Stuart, J. Grimes, K. Harlos, 2013, Cell reports.

The N-Terminus of the RNA Polymerase from Infectious Pancreatic Necrosis Virus Is the Determinant of Genome Attachment

D. Stuart, P. D. Nagy, J. Grimes, 2011, PLoS pathogens.

Insights into virus evolution and membrane biogenesis from the structure of the marine lipid-containing bacteriophage PM2.

D. Stuart, N. Abrescia, J. Grimes, 2008, Molecular cell.

Towards in cellulo virus crystallography

D. Stuart, J. Grimes, D. Bamford, 2018, Scientific Reports.

Plate Tectonics of Virus Shell Assembly and Reorganization in Phage Φ8, a Distant Relative of Mammalian Reoviruses

E. Mancini, D. Stuart, J. Grimes, 2013, Structure.

Enisamium is a small molecule inhibitor of the influenza A virus and SARS-CoV-2 RNA polymerases

J. Grimes, J. Keown, E. Fodor, 2020, bioRxiv.

Noncatalytic Ions Direct the RNA-Dependent RNA Polymerase of Bacterial Double-Stranded RNA Virus ϕ6 from De Novo Initiation to Elongation

D. Stuart, J. Grimes, D. Bamford, 2011, Journal of Virology.

Structural explanation for the role of Mn2+ in the activity of ϕ6 RNA-dependent RNA polymerase

D. Stuart, J. Grimes, D. Bamford, 2008, Nucleic acids research.

Back-priming mode of phi6 RNA-dependent RNA polymerase.

D. Stuart, J. Grimes, D. Bamford, 2005, The Journal of general virology.

Short Communication Back-priming mode of w6 RNA-dependent RNA polymerase

D. Stuart, J. Grimes, D. Bamford, 2005 .

A mechanism for initiating RNA-dependent RNA polymerization

E. V. Makeyev, D. Stuart, J. Grimes, 2001, Nature.

Genomics and structure/function studies of Rhabdoviridae proteins involved in replication and transcription.

P. Tucker, R. Owens, D. Stuart, 2010, Antiviral research.

Structure of CrmE, a virus-encoded tumour necrosis factor receptor.

D. Stuart, N. Abrescia, J. Grimes, 2007, Journal of molecular biology.

X-ray structure and activities of an essential Mononegavirales L-protein domain

E. Decroly, G. Paesen, J. Grimes, 2015, Nature Communications.

The Structure of HIV-1 Rev Filaments Suggests a Bilateral Model for Rev-RRE Assembly.

D. Stuart, P. Wingfield, A. Steven, 2016, Structure.

Generation and characterization of a chimeric rabbit/human Fab for co-crystallization of HIV-1 Rev.

D. Stuart, P. Wingfield, S. Stahl, 2010, Journal of molecular biology.

In Vitro Activities of the Multifunctional RNA Silencing Polymerase QDE-1 of Neurospora crassa*

D. Stuart, J. Grimes, D. Bamford, 2010, The Journal of Biological Chemistry.

A revised partiality model and post-refinement algorithm for X-ray free-electron laser data

Nicholas K. Sauter, Helen Mary Ginn, Gwyndaf Evans, 2015, Acta crystallographica. Section D, Biological crystallography.

Order and disorder in crystals of hexameric NTPases from dsRNA bacteriophages.

E. Mancini, D. Stuart, R. Tuma, 2003, Acta crystallographica. Section D, Biological crystallography.

The conserved protein Seb1 drives transcription termination by binding RNA polymerase II and nascent RNA

P. Cramer, J. Grimes, M. Renner, 2017, Nature Communications.

The C-Terminal Domains of the PB2 Subunit of the Influenza A Virus RNA Polymerase Directly Interact with Cellular GTPase Rab11a

Marjorie Fournier, J. Grimes, J. Keown, 2022, Journal of virology.

Hybrid vigor: hybrid methods in viral structure determination.

D. Stuart, J. Grimes, R. Gilbert, 2003, Advances in protein chemistry.

Structural Basis of Mechanochemical Coupling in a Hexameric Molecular Motor*

E. Mancini, D. Stuart, R. Tuma, 2008, Journal of Biological Chemistry.

RNA-dependent RNA polymerases of dsRNA bacteriophages.

J. Grimes, E. Makeyev, 2004, Virus research.

Detection of a Fourth Orbivirus Non-Structural Protein

A. Firth, J. Grimes, F. Mohd Jaafar, 2011, PloS one.

Inhibition of Apoptosis and NF-κB Activation by Vaccinia Protein N1 Occur via Distinct Binding Surfaces and Make Different Contributions to Virulence

D. Stuart, J. Grimes, S. Cooray, 2011, PLoS pathogens.

Functional and structural studies of the vaccinia virus virulence factor N1 reveal a Bcl-2-like anti-apoptotic protein

D. Stuart, N. Abrescia, J. Grimes, 2007, The Journal of general virology.

The crystal structure of bluetongue virus VP7

Jonathan Grimes, D. Stuart, J. Grimes, 1995, Nature.

Insights into the pre-initiation events of bacteriophage φ6 RNA-dependent RNA polymerase: towards the assembly of a productive binary complex

D. Stuart, J. Grimes, D. Bamford, 2009, Nucleic acids research.

Insights into the pre-initiation events of bacteriophage phi6 RNA-dependent RNA polymerase Sarin,

D. Stuart, J. Grimes, D. Bamford, 2022 .

The Crystal Structure of Plasma Gelsolin: Implications for Actin Severing, Capping, and Nucleation

Jonathan Grimes, David I. Stuart, Paul J. McLaughlin, 1997, Cell.

Germline mutations in the proofreading domains of POLE and POLD 1 predispose to colorectal adenomas and carcinomas

P. Donnelly, G. McVean, D. Bentley, 2022 .

Structural insights into RNA polymerases of negative-sense RNA viruses

J. Grimes, E. Fodor, A. J. T. te Velthuis, 2021, Nature Reviews Microbiology.

Host ANP32A mediates the assembly of the influenza virus replicase

J. Grimes, J. Keown, E. Fodor, 2020, Nature.

A Mechanism for the Activation of the Influenza Virus Transcriptase

J. Grimes, M. Renner, E. Fodor, 2018, Molecular cell.

An atomic model of the outer layer of the bluetongue virus core derived from X-ray crystallography and electron cryomicroscopy.

W Chiu, J Jakana, D I Stuart, 1997, Structure.

How vaccinia virus has evolved to subvert the host immune response

D. Stuart, J. Grimes, S. Cooray, 2011, Journal of structural biology.

Rhabdovirus Matrix Protein Structures Reveal a Novel Mode of Self-Association

R. Owens, D. Stuart, J. Grimes, 2008, PLoS pathogens.

The structure of the nucleoprotein binding domain of lyssavirus phosphoprotein reveals a structural relationship between the N-RNA binding domains of Rhabdoviridae and Paramyxoviridae

J. Grimes, R. Assenberg, O. Delmas, 2010, RNA biology.

Structures of influenza A virus RNA polymerase offer insight into viral genome replication

E. Pardon, J. Steyaert, J. Grimes, 2019, Nature.

Crystal structure of the RNA-dependent RNA polymerase from influenza C virus

D. Stuart, G. Bricogne, C. Vonrhein, 2015, Nature.

The C-terminal priming domain is strongly associated with the main body of bacteriophage ϕ6 RNA-dependent RNA polymerase.

D. Stuart, J. Grimes, D. Bamford, 2012, Virology.

Structural studies on orbivirus proteins and particles.

D. Stuart, J. Grimes, 2006, Current topics in microbiology and immunology.

The Core of Bluetongue Virus Binds Double-Stranded RNA

J. M. Diprose, D. I. Stuart, D. Stuart, 2002, Journal of Virology.

Nucleocapsid assembly in pneumoviruses is regulated by conformational switching of the N protein

M. Bertinelli, G. Paesen, J. Grimes, 2016, eLife.

The methyltransferase domain of the Sudan ebolavirus L protein specifically targets internal adenosines of RNA substrates, in addition to the cap structure

B. Coutard, E. Decroly, G. Paesen, 2018, Nucleic acids research.

Structure unifies the viral universe.

D. Stuart, N. Abrescia, J. Grimes, 2012, Annual review of biochemistry.

What does structure tell us about virus evolution?

D. Stuart, J. Grimes, D. Bamford, 2005, Current opinion in structural biology.

Structure of the TRAIL–DR5 complex reveals mechanisms conferring specificity in apoptotic initiation

D. Stuart, G. Screaton, J. Grimes, 1999, Nature Structural Biology.

Vaccinia Virus Proteins A52 and B14 Share a Bcl-2–Like Fold but Have Evolved to Inhibit NF-κB rather than Apoptosis

R. Owens, D. Stuart, N. Abrescia, 2008, PLoS pathogens.

Crystal Structure and Carbohydrate Analysis of Nipah Virus Attachment Glycoprotein: a Template for Antiviral and Vaccine Design

D. Stuart, J. Grimes, E. Jones, 2008, Journal of Virology.

The Structure of the N-RNA Binding Domain of the Mokola Virus Phosphoprotein

P. Vidalain, J. Grimes, F. Tangy, 2009 .

The VIZIER project: Preparedness against pathogenic RNA viruses

D I Stuart, A. M. Leontovich, T A Jones, 2007, Antiviral Research.

Diamond Light Source: contributions to SARS-CoV-2 biology and therapeutics

D. Stuart, J. Grimes, M. Walsh, 2020, Biochemical and Biophysical Research Communications.

Multiple liquid crystalline geometries of highly compacted nucleic acid in a dsRNA virus

D. Stuart, F. De Haas, J. Grimes, 2019, Nature.

Characterization of a potent and highly unusual minimally enhancing antibody directed against dengue virus

C. Midgley, G. Screaton, J. Grimes, 2018, Nature Immunology.

A new class of highly potent, broadly neutralizing antibodies isolated from viremic patients infected with dengue virus

J. Farrar, G. Screaton, F. Rey, 2014, Nature Immunology.

Flavivirus maturation leads to the formation of an occupied lipid pocket in the surface glycoproteins

G. Screaton, J. Grimes, M. Renner, 2021, Nature Communications.

Structure of the Nucleoprotein Binding Domain of Mokola Virus Phosphoprotein

P. Vidalain, J. Grimes, F. Tangy, 2009, Journal of Virology.

Insights into the Evolution of a Complex Virus from the Crystal Structure of Vaccinia Virus D13

David I. Stuart, Stephen C. Graham, D. Stuart, 2011, Structure.

The role of gelsolin domain 3 in familial amyloidosis (Finnish type)

Adelene Y. L. Sim, Weitong Ren, Wenfei Li, 2019, Proceedings of the National Academy of Sciences.

The Crystal Structure of ORF-9b, a Lipid Binding Protein from the SARS Coronavirus

David I. Stuart, A. Radu Aricescu, C. Meier, 2006, Structure.

Activity and specificity of human aldolases.

G J Davies, R M Jackson, J A Littlechild, 1991, Journal of molecular biology.

Atomic Snapshots of an RNA Packaging Motor Reveal Conformational Changes Linking ATP Hydrolysis to RNA Translocation

E. Mancini, D. Stuart, R. Tuma, 2004, Cell.

Application of the use of high‐throughput technologies to the determination of protein structures of bacterial and viral pathogens

R. Owens, D. Stuart, P. Nordlund, 2006, Acta Crystallographica Section D: Biological Crystallography.

Structural Analysis of a Dengue Cross-Reactive Antibody Complexed with Envelope Domain III Reveals the Molecular Basis of Cross-Reactivity

C. Midgley, G. Screaton, J. Grimes, 2012, The Journal of Immunology.

Crystal structure of the top domain of African horse sickness virus VP7: comparisons with bluetongue virus VP7.

D. Stuart, J. Grimes, P. Roy, 1996, Journal of virology.

Insights into assembly from structural analysis of bacteriophage PRD1

D. Stuart, S. Fuller, R. M. Burnett, 2004, Nature.

Crystal structure and carbohydrate analysis of Nipah virus attachment glycoprotein

D. Stuart, J. Grimes, E. Jones, 2016 .

Lawrence Berkeley National Laboratory Recent Work Title Structure of CPV 17 polyhedrin determined by the improved analysis of serial femtosecond crystallographic data

D. Stuart, M. Messerschmidt, J. Grimes, 2015 .

Tracking in atomic detail the functional specializations in viral RecA helicases that occur during evolution

C. Meier, E. Mancini, D. Stuart, 2013, Nucleic acids research.

Bacteriophage P23-77 Capsid Protein Structures Reveal the Archetype of an Ancient Branch from a Major Virus Lineage

D. Stuart, J. Grimes, I. Rissanen, 2013, Structure.

Structure and Function of A41, a Vaccinia Virus Chemokine Binding Protein

D. Stuart, N. Abrescia, J. Grimes, 2008, PLoS pathogens.

Crystal structure of the Murray Valley encephalitis virus NS5 methyltransferase domain in complex with cap analogues.

R. Owens, D. Stuart, S. Fuller, 2007, The Journal of general virology.

Structures of orbivirus VP7: implications for the role of this protein in the viral life cycle.

D. Stuart, J. Grimes, P. Roy, 1997, Structure.

Structure and functionality in flavivirus NS-proteins: Perspectives for drug design

David I. Stuart, Rolf Hilgenfeld, Raymond J. Owens, 2010, Antiviral research.

Large unit cells and cellular mechanics

D. Stuart, J. Grimes, 1998, Nature Structural Biology.

The structure of a cypovirus and the functional organization of dsRNA viruses

D. Stuart, B. Prasad, J. Grimes, 1999, Nature Structural Biology.

Virus crystallography

D. Stuart, J. Grimes, E. Fry, 1999, Molecular biotechnology.

Crystallization and preliminary X-ray crystallographic studies on the bacteriophage Φ6 RNA-dependent RNA polymerase

E. V. Makeyev, D. Stuart, J. Grimes, 2000 .

Mechanisms of Yersinia YopO kinase substrate specificity

R. Robinson, K. Swaminathan, J. Grimes, 2017, Scientific Reports.

Yersinia effector YopO uses actin as bait to phosphorylate proteins that regulate actin polymerization

R. Robinson, J. Grimes, W. Lee, 2015, Nature Structural &Molecular Biology.

Structural basis of thymosin-β4/profilin exchange leading to actin filament polymerization

R. Robinson, J. Grimes, C. Leyrat, 2014, Proceedings of the National Academy of Sciences.

AMechanism for the Activ ation of the Influenza Virus Transcriptase Graphical Abstract Highlights

J. Grimes, M. Renner, E. Fodor, 2018 .

Host ANP32A mediates the assembly of the influenza virus replicase

J. Grimes, J. Keown, E. Fodor, 2020, Nature.

Crystal lattice as biological phenotype for insect viruses

D. Stuart, J. Grimes, J. Diprose, 2005, Protein science : a publication of the Protein Society.

Basis of Cross-Reactivity Envelope Domain III Reveals the Molecular Cross-Reactive Antibody Complexed with Structural Analysis of a Dengue

C. Midgley, J. Grimes, Gavin, 2012 .

Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies

E. Pardon, J. Steyaert, J. Grimes, 2022, Nature communications.

A procedure for setting up high‐throughput nanolitre crystallization experiments. Crystallization workflow for initial screening, automated storage, imaging and optimization

Lester G. Carter, L. Carter, R. Owens, 2005, Acta crystallographica. Section D, Biological crystallography.

Lysine Methylation as a Routine Rescue Strategy for Protein Crystallization

Anil Verma, David I. Stuart, Raymond J. Owens, 2006, Structure.

Diffraction quality crystals of PRD1, a 66-MDa dsDNA virus with an internal membrane.

D. Stuart, J. Grimes, D. Bamford, 2002, Journal of structural biology.

Crystallization and preliminary X-ray analysis of the core particle of bluetongue virus.

D. Stuart, J. Burroughs, J. Grimes, 1995, Virology.

Structure Elucidation of Coxsackievirus A16 in Complex with GPP3 Informs a Systematic Review of Highly Potent Capsid Binders to Enteroviruses

D. Stuart, Z. Rao, J. Grimes, 2015, PLoS pathogens.

High-resolution crystal structure of arthropod Eiger TNF suggests a mode of receptor engagement and altered surface charge within endosomes

M. Bertinelli, G. Paesen, J. Grimes, 2019, Communications Biology.

Structural dissection of human metapneumovirus phosphoprotein using small angle x-ray scattering

G. Paesen, J. Grimes, M. Renner, 2017, Scientific Reports.

Structural Characterization of the Full-length Hantaan Virus Polymerase

J. Grimes, J. Keown, E. Fodor, 2023, bioRxiv.

Atomic structure of a nudivirus occlusion body protein determined from a 70-year-old crystal sample

J. Grimes, J. Keown, G. Evans, 2023, Nature communications.

Going soft and SAD with manganese.

D. Stuart, J. Grimes, M. Walsh, 2005, Acta crystallographica. Section D, Biological crystallography.

Insights from the crystal structure of the chicken CREB3 bZIP suggest that members of the CREB3 subfamily transcription factors may be activated in response to oxidative stress

R. Owens, G. Paesen, J. Grimes, 2019, Protein science : a publication of the Protein Society.

Design, Synthesis, and Biological Evaluation of Novel Indoles Targeting the Influenza PB2 Cap Binding Region.

Christophe Buyck, J. Grimes, J. Keown, 2019, Journal of medicinal chemistry.

Semi-automated microseeding of nanolitre crystallization experiments.

S. Sainsbury, E. Mancini, R. Owens, 2008, Acta crystallographica. Section F, Structural biology and crystallization communications.

Multiple liquid crystalline geometries of highly compacted nucleic acid in a dsRNA virus

D. Stuart, J. Grimes, J. Huiskonen, 2019, Nature.

Complementing crystallography: the role of cryo-electron microscopy in structural biology.

D I Stuart, D. Stuart, J. Grimes, 1999, Acta crystallographica. Section D, Biological crystallography.

Protein target highlights in CASP15: Analysis of models by structure providers

Peter L. Freddolino, Mitchell D. Miller, K. Fidelis, 2023, Proteins.

Macromolecular assemblies: greater than their parts.

D. Stuart, J. Grimes, D. Bamford, 2001, Current opinion in structural biology.

Yersinia effector protein (YopO)-mediated phosphorylation of host gelsolin causes calcium-independent activation leading to disruption of actin dynamics

U. Ghoshdastider, R. Robinson, K. Swaminathan, 2017, The Journal of Biological Chemistry.

Structure of an H3N2 influenza virus nucleoprotein

J. Grimes, J. Keown, E. Fodor, 2021, Acta crystallographica. Section F, Structural biology communications.

Calcium-controlled conformational choreography in the N-terminal half of adseverin

R. Robinson, J. Grimes, C. Leyrat, 2015, Nature Communications.

What Does it Take to Make a Virus: The Concept of the Viral 'Self'

D. Stuart, J. Grimes, D. Bamford, 2010 .

The structural basis for RNA specificity and Ca2 inhibition of an RNA-dependent RNA polymerase phi6p2 with 5NT RNA conformation A

D. Stuart, J. Grimes, D. Bamford, 2004 .

The structural basis for RNA specificity and Ca2+ inhibition of an RNA-dependent RNA polymerase.

D. Stuart, J. Grimes, D. Bamford, 2004, Structure.

Unexpected structure for the N-terminal domain of hepatitis C virus envelope glycoprotein E1

D. Stuart, J. Grimes, K. Harlos, 2014, Nature Communications.

Pushing the limits of sulfur SAD phasing: de novo structure solution of the N-terminal domain of the ectodomain of HCV E1

D. Stuart, D. Hall, J. Grimes, 2014, Acta crystallographica. Section D, Biological crystallography.

Drastic changes in conformational dynamics of the antiterminator M2-1 regulate transcription efficiency in Pneumovirinae

J. Grimes, M. Renner, J. Huiskonen, 2014, eLife.

Adipogenesis : From Stem Cell to Adipocyte

D. Stuart, J. Cooper, R. Kaufman, 2012 .

SynchLink: an iOS app for ISPyB

Helen Mary Ginn, David Ian Stuart, Ghita Kouadri Mostefaoui, 2014, Journal of applied crystallography.

Adipogenesis: from stem cell to adipocyte.

M. Lane, J. Grimes, R. Farese, 2012, Annual review of biochemistry.

An In-Depth Analysis of Original Antigenic Sin in Dengue Virus Infection

C. Midgley, G. Screaton, S. Yoksan, 2010, Journal of Virology.

Structure and functionality in flavivirus NS-proteins: Perspectives for drug design

M. Bolognesi, E. Mancini, R. Owens, 2010, Antiviral research.

3H5 Fab bound to EDIII of DenV 2 Xtal form 2

G. Screaton, J. Grimes, M. Renner, 2018 .

Characterization of a potent and highly unusual minimally enhancing antibody directed against dengue virus

C. Midgley, G. Screaton, J. Grimes, 2018, Nature Immunology.

Bluetongue virus: the role of synchrotron radiation

D. Stuart, J. Burroughs, J. Lescar, 1999 .

Experimental phasing opportunities for macromolecular crystallography at very long wavelengths

E. Mancini, J. Grimes, M. Renner, 2023, Communications chemistry.

Insights into virus evolution and membrane biogenesis from the structure of the marine lipid-containing bacteriophage PM2.

D. Stuart, N. Abrescia, J. Grimes, 2008, Molecular cell.

EctodomainGlycoprotein Structural Insights into the Human

G. Paesen, J. Grimes, C. Leyrat, 2014 .

Production, crystallization and preliminary X-ray crystallographic studies of the bacteriophage phi 12 packaging motor.

E. Mancini, D. Stuart, P. Gottlieb, 2004, Acta crystallographica. Section D, Biological crystallography.

Structural Analysis of a Dengue Cross-Reactive Antibody Complexed with Envelope Domain III Reveals the Molecular Basis of Cross-Reactivity

C. Midgley, G. Screaton, J. Grimes, 2012, The Journal of Immunology.

Influenza A virus RNA polymerase structures provide insights into viral genome 2 replication 3

E. Pardon, J. Steyaert, J. Grimes, 2019 .

Structure of the RNA-dependent RNA polymerase from influenza C virus

J. Grimes, 2014 .