P. Paszek

发表

Physiological levels of TNFα stimulation induce stochastic dynamics of NF-κB responses in single living cells

David A. Rand, David G. Spiller, David E. Nelson, 2010, Journal of Cell Science.

Stochasticity in the miR-9/Hes1 oscillatory network can account for clonal heterogeneity in the timing of differentiation

M. Rattray, T. Galla, D. Spiller, 2016, eLife.

Population robustness arising from cellular heterogeneity

Claire V. Harper, D. Rand, D. Spiller, 2010, Proceedings of the National Academy of Sciences.

Integration of Kinase and Calcium Signaling at the Level of Chromatin Underlies Inducible Gene Activation in T Cells

Nigel P. Dyer, S. Ott, A. Pisco, 2017, The Journal of Immunology.

Macrophage-Specific NF-κB Activation Dynamics Can Segregate Inflammatory Bowel Disease Patients

M. White, P. Paszek, D. Jackson, 2019, bioRxiv.

Transcriptional stochasticity in gene expression.

Marek Kimmel, Tomasz Lipniacki, Pawel Paszek, 2006, Journal of theoretical biology.

Stochastic regulation in early immune response.

Marek Kimmel, Tomasz Lipniacki, Pawel Paszek, 2006, Biophysical journal.

Signal transduction controls heterogeneous NF-κB dynamics and target gene expression through cytokine-specific refractory states

Claire V. Harper, Pawel Paszek, William Rowe, 2016, Nature Communications.

Mathematical model of NF- κB regulatory module

Marek Kimmel, Tomasz Lipniacki, Allan R. Brasier, 2004 .

Gene-Specific Linear Trends Constrain Transcriptional Variability of the Toll-like Receptor Signaling

Mark R. Muldoon, M. Platt, P. Paszek, 2020, Cell systems.

A method of ‘speed coefficients’ for biochemical model reduction applied to the NF-\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begi

M. White, P. Paszek, V. Biktashev, 2014, Journal of Mathematical Biology.

Heat shock response regulates stimulus-specificity and sensitivity of the pro-inflammatory NF-κB signalling

J. Śmieja, M. Kimmel, D. Spiller, 2020, Cell Communication and Signaling.

Heat shock response pathways regulate stimulus-specificity and sensitivity of NF-κB signalling to temperature stress

J. Śmieja, M. Kimmel, D. Spiller, 2019, bioRxiv.

Post-transcriptional regulatory feedback encodes JAK-STAT signal memory of interferon stimulation

J. Śmieja, D. Spiller, P. Paszek, 2022, bioRxiv.

Macrophage-Specific NF-κB Activation Dynamics Can Segregate Inflammatory Bowel Disease Patients

V. M. D. Martins dos Santos, D. Spiller, M. White, 2019, Frontiers in immunology.

Single-cell imaging reveals non-cooperative and cooperative infection strategies of Listeria monocytogenes in macrophages

D. Spiller, P. Paszek, J. Bagnall, 2022, bioRxiv.

Investigating IL-1β Secretion Using Real-Time Single-Cell Imaging.

D. Brough, D. Spiller, M. White, 2016, Methods in molecular biology.

Application of Sensitivity Analysis to Discover Potential Molecular Drug Targets

J. Śmieja, K. Puszynski, P. Paszek, 2022, International journal of molecular sciences.

A systematic survey of the response of a model NF-κB signalling pathway to TNFα stimulation

David S. Broomhead, Douglas B. Kell, Pawel Paszek, 2012, Journal of theoretical biology.

A method of ‘speed coefficients’ for biochemical model reduction applied to the NF-κB system.

M. White, P. Paszek, V. Biktashev, 2015, Journal of mathematical biology.

Oscillatory control of signalling molecules.

M. White, P. Paszek, D. Jackson, 2010, Current opinion in genetics & development.

Inflammasome-dependent IL-1β release depends upon membrane permeabilisation

D. Brough, D. Spiller, M. White, 2016, Cell Death and Differentiation.

Quantitative analysis of competitive cytokine signaling predicts tissue thresholds for the propagation of macrophage activation

D. Spiller, M. White, R. Brignall, 2018, Science Signaling.

Dynamic NF-κB and E2F interactions control the priority and timing of inflammatory signalling and cell proliferation

Claire V. Harper, Pawel Paszek, Lloyd Bridge, 2016, eLife.

Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer's disease in rodent models

D. Brough, P. Paszek, J. Bagnall, 2016, Nature Communications.

Interactions among oscillatory pathways in NF-kappa B signaling

David S. Broomhead, Douglas B. Kell, Michael R. H. White, 2011, BMC Systems Biology.

Single TNFα trimers mediating NF-κB activation: stochastic robustness of NF-κB signaling

Marek Kimmel, Krzysztof Puszynski, Tomasz Lipniacki, 2007, BMC Bioinformatics.

Quantitative dynamic imaging of immune cell signalling using lentiviral gene transfer.

D. Spiller, M. White, R. Brignall, 2015, Integrative biology : quantitative biosciences from nano to macro.

Pulsatile Stimulation Determines Timing and Specificity of NF-κB-Dependent Transcription

D. S. Broomhead, Claire V. Harper, D. Broomhead, 2009, Science.

Variability of the innate immune response is globally constrained by transcriptional bursting

P. Paszek, M. Muldoon, D. Norton, 2023, bioRxiv.

From measuring noise toward integrated single-cell biology

Pawel Paszek, P. Paszek, 2014, Front. Genet..

Overexpression of IκB⍺ modulates NF-κB activation of inflammatory target gene expression

D. Spiller, P. Paszek, D. Jackson, 2023, bioRxiv.

Dynamic NF-kB and E2F interactions control the priority and timing of inflammatory signalling and cell proliferation

V. Sée, D. Spiller, M. White, 2016 .

Modeling Stochasticity in Gene Regulation: Characterization in the Terms of the Underlying Distribution Function

Pawel Paszek, P. Paszek, 2007, Bulletin of mathematical biology.

Anti‐inflammatory effects of infliximab in mice are independent of tumour necrosis factor α neutralization

J. Mclaughlin, P. Paszek, J. Bagnall, 2016, Clinical and experimental immunology.

Quantitative analysis reveals crosstalk mechanisms of heat shock-induced attenuation of NF-κB signaling at the single cell level

Jaroslaw Smieja, Marek Kimmel, Malgorzata Kardynska, 2018, PLoS Comput. Biol..

Stochastic effects of multiple regulators on expression profiles in eukaryotes.

Marek Kimmel, Tomasz Lipniacki, Pawel Paszek, 2005, Journal of theoretical biology.

A method of ‘speed coefficients’ for biochemical model reduction applied to the NF-$$\upkappa $$κB system

Michael R. H. White, Vadim N. Biktashev, Pawel Paszek, 2014, 1403.1610.

Additional le 2 : Model parameters and their justi cation

M. Kimmel, T. Lipniacki, P. Paszek, 2007 .

Live-cell imaging reveals single-cell and population-level infection strategies of Listeria monocytogenes in macrophages

D. Spiller, P. Paszek, J. Bagnall, 2023, Frontiers in immunology.

Dynamic organisation of prolactin gene expression in living pituitary tissue

Karen Featherstone, David G. Spiller, Julian R. E. Davis, 2010, Journal of Cell Science.

The comparable tumour microenvironment in sporadic and NF2-related schwannomatosis vestibular schwannoma

D. Brough, P. Paszek, D. G. Evans, 2023, Brain communications.

Oscillatory control of signalling molecules.

M. White, P. Paszek, D. Jackson, 2010, Current opinion in genetics & development.

Working together to control mutation: how collective peroxide detoxification determines microbial mutation rate plasticity

P. Paszek, R. Krašovec, Christopher G. Knight, 2023, bioRxiv.

Quantitative dynamic imaging of immune cell signalling using lentiviral gene transfer.

D. Spiller, M. White, P. Paszek, 2015, Integrative biology : quantitative biosciences from nano to macro.