G. Saxty

发表

Current Trends in Macrocyclic Drug Discovery and beyond-Ro5.

S. Alihodžić, Mirjana Bukvić, I. Elenkov, 2018, Progress in medicinal chemistry.

Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a novel cyclin dependent kinase inhibitor using fragment-based X-ray crystallography and structure based drug design.

Paul G Wyatt, Valerio Berdini, V. Berdini, 2008, Journal of medicinal chemistry.

Identification of orally bioavailable small-molecule inhibitors of hematopoietic prostaglandin D2 synthase using X-ray fragment based drug discovery

Paul N. Mortenson, Melanie V. Leveridge, S. Teague, 2014 .

FBDD Applications to Kinase Drug Hunting

G. Saxty, 2016 .

A Fragment-Derived Clinical Candidate for Antagonism of X-Linked and Cellular Inhibitor of Apoptosis Proteins: 1-(6-[(4-Fluorophenyl)methyl]-5-(hydroxymethyl)-3,3-dimethyl-1 H,2 H,3 H-pyrrolo[3,2- b]pyridin-1-yl)-2-[(2 R,5 R)-5-methyl-2-([(3R)-3-methylmorpholin-4-yl]methyl)piperazin-1-yl]ethan-1-one

G. Chessari, P. Williams, G. Saxty, 2018, Journal of medicinal chemistry.

Identification of inhibitors of protein kinase B using fragment-based lead discovery.

Marcel L Verdonk, Paul G Wyatt, Michelle D Garrett, 2007, Journal of medicinal chemistry.

Discovery and Pharmacological Characterization of JNJ-42756493 (Erdafitinib), a Functionally Selective Small-Molecule FGFR Family Inhibitor

C. Murray, J. Vialard, D. Newell, 2017, Molecular Cancer Therapeutics.

Monoacidic Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery.

H. Willems, G. Saxty, T. Davies, 2016, Journal of medicinal chemistry.

Fragment-Based Discovery of Potent and Selective DDR1/2 Inhibitors.

Christopher W Murray, Paul N. Mortenson, Valerio Berdini, 2015, ACS medicinal chemistry letters.

The exploration of aza-quinolines as hematopoietic prostaglandin D synthase (H-PGDS) inhibitors with low brain exposure.

Paul N. Mortenson, D. J. Price, L. Shewchuk, 2020, Bioorganic & medicinal chemistry.

Structure-Activity and Structure-Conformation Relationships of Aryl Propionic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1/Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1/NRF2) Protein-Protein Interaction.

Paul N. Mortenson, W. Rumsey, H. Willems, 2019, Journal of medicinal chemistry.

The discovery of quinoline-3-carboxamides as hematopoietic prostaglandin D synthase (H-PGDS) inhibitors.

I. E. Smith, Paul N. Mortenson, D. J. Price, 2019, Bioorganic & medicinal chemistry.

Abstract 1738: JNJ-42756493 is an inhibitor of FGFR-1, 2, 3and4 with nanomolar affinity for targeted therapy

C. Murray, J. Vialard, D. Newell, 2014 .

Novel Macrocyclic Antagonists of the Calcitonin Gene-Related Peptide Receptor: Design, Realization, and Structural Characterization of Protein-Ligand Complexes.

M. Congreve, J. Mason, A. Bortolato, 2022, ACS chemical neuroscience.