J. Emsley

发表

Structure of the USP15 N-terminal domains: a β-hairpin mediates close association between the DUSP and UBL domains.

D. Scott, S. Harper, T. M. Besong, 2011, Biochemistry.

Quaternary organization of GPIb-IX complex and insights into Bernard-Soulier syndrome revealed by the structures of GPIbβ and a GPIbβ/GPIX chimera.

P. McEwan, J. Emsley, Wenjun Yang, 2011, Blood.

Structure of pentameric human serum amyloid P component

T. Blundell, N. Srinivasan, J. Emsley, 1994, Nature.

Coagulation factor XII protease domain crystal structure

J. Emsley, I. Dreveny, M. Pathak, 2015, Journal of thrombosis and haemostasis : JTH.

PqsBC, a Condensing Enzyme in the Biosynthesis of the Pseudomonas aeruginosa Quinolone Signal

Chan Li, J. Emsley, I. Dreveny, 2016, The Journal of Biological Chemistry.

A Common Fold Mediates Vertebrate Defense and Bacterial Attack

Ashley M Buckle, Corrine J Porter, James C Whisstock, 2007, Science.

Convergent recognition of a triple helical hydrophobic motif in collagen.

J. Emsley, Jonas Emsley, 2010, Structure.

The crystal structure of the platelet activator aggretin reveals a novel (alphabeta)2 dimeric structure.

J. Emsley, A. Pandey, K. Clemetson, 2008, Biochemistry.

Crystal Structure of the I Domain from Integrin α2β1*

R. Liddington, J. Emsley, J. Bergelson, 1997, The Journal of Biological Chemistry.

The Activity of the Vinculin Binding Sites in Talin Is Influenced by the Stability of the Helical Bundles That Make Up The Talin Rod*

R. Liddington, G. Roberts, J. Emsley, 2006, Journal of Biological Chemistry.

Structure of Mycobacterium tuberculosis thioredoxin C.

Charles Laughton, P. McEwan, C. Laughton, 2006, Acta crystallographica. Section D, Biological crystallography.

Structure of Mycobacterium tuberculosis thioredoxin in complex with quinol inhibitor PMX464

C. Laughton, J. Emsley, T. Bradshaw, 2011, Protein science : a publication of the Protein Society.

An update on factor XII-driven vascular inflammation.

T. Renné, J. Emsley, Reiner K. Mailer, 2021, Biochimica et biophysica acta. Molecular cell research.

Crystal Structure of the Platelet Glycoprotein Ibα N-terminal Domain Reveals an Unmasking Mechanism for Receptor Activation*

J. Emsley, K. Clemetson, Jonas Emsley, 2002, The Journal of Biological Chemistry.

Gene of the issue: GP1BA gene mutations associated with bleeding

J. Emsley, M. Othman, 2017, Platelets.

The organizing principle of the platelet glycoprotein Ib–IX–V complex

J. Emsley, Renhao Li, R. Li, 2013, Journal of thrombosis and haemostasis : JTH.

Crystal Structure of the von Willebrand Factor A1 Domain and Implications for the Binding of Platelet Glycoprotein Ib*

R. Liddington, J. Emsley, R. Handin, 1998, The Journal of Biological Chemistry.

Illustrated State‐of‐the‐Art Capsules of the ISTH 2019 Congress in Melbourne, Australia

C. Maas, L. Rauova, J. Eikelboom, 2019, Research and practice in thrombosis and haemostasis.

Proteolytic properties of single-chain factor XII: a mechanism for triggering contact activation.

J. Emsley, I. Verhamme, D. Gailani, 2017, Blood.

Protein three-dimensional structure and molecular recognition: a story of soft locks and keys

T. Blundell, S. Rufino, R. Sowdhamini, 1995 .

Integrin connections to the cytoskeleton through talin and vinculin.

J. Emsley, D. Critchley, A. Gingras, 2008, Biochemical Society transactions.

Drees, Steffen Lorenz and Li, Chan and Prasetya, Fajar and Saleem, Muhammad and Dreveny, Ingrid and Williams, Paul and Hennecke, Ulrich and Emsley, Jonas and Fetzner, Susanne (2016) PqsBC, a condensing enzyme in the biosynthesis of the Pseudomonas

Chan Li, J. Emsley, I. Dreveny, 2018 .

Assessment of the protein interaction between coagulation factor XII and corn trypsin inhibitor by molecular docking and biochemical validation

J. Emsley, M. Pathak, P. Fischer, 2017, Journal of thrombosis and haemostasis : JTH.

Structure and Catalytic Regulatory Function of Ubiquitin Specific Protease 11 N-Terminal and Ubiquitin-like Domains

D. Scott, S. Harper, J. Emsley, 2014, Biochemistry.

Novel quinazolinone inhibitors of the Pseudomonas aeruginosa quorum sensing transcriptional regulator PqsR

J. Emsley, M. Cámara, P. Williams, 2020, European journal of medicinal chemistry.

Crystal structure and substrate-induced activation of ADAMTS13

Chan Li, J. Emsley, Hyo Jung Kim, 2019, Nature Communications.

Wong, Szu S. and Østergaard, Søren and Hall, Gareth and Li, Chan and Williams, Philip M. and Stennicke, Henning and Emsley, Jonas (2016) A novel DFP tripeptide motif interacts with the coagulation factor XI

Chan Li, J. Emsley, S. Østergaard, 2018 .

“Bleeding in the jungle”

J. Emsley, M. Othman, E. Favaloro, 2015, American journal of hematology.

A novel DFP tripeptide motif interacts with the coagulation factor XI apple 2 domain.

Chan Li, J. Emsley, S. Østergaard, 2016, Blood.

A vinculin binding domain from the talin rod unfolds to form a complex with the vinculin head.

G. Roberts, J. Emsley, D. Critchley, 2005, Structure.

End-stapled homo and hetero collagen triple helices: a click chemistry approach.

P. McEwan, P. Fischer, J. Emsley, 2011, Chemical communications.

The evolution of factor XI and the kallikrein-kinin system.

A. Gruber, J. Emsley, M. Ponczek, 2020, Blood advances.

Structural Basis for Native Agonist and Synthetic Inhibitor Recognition by the Pseudomonas aeruginosa Quorum Sensing Regulator PqsR (MvfR)

P. Williams, J. Emsley, S. Heeb, 2013, PLoS pathogens.

Crystal structure of Leishmania mexicana cysteine protease B in complex with a high-affinity azadipeptide nitrile inhibitor.

Chan Li, J. Emsley, J. Lameira, 2020, Bioorganic & medicinal chemistry.

Structure and function of factor XI.

P. McEwan, J. Emsley, D. Gailani, 2010, Blood.

Synthetic glycopolymers and natural fucoidans cause human platelet aggregation via PEAR1 and GPIbα.

S. Watson, J. Emsley, M. Hoylaerts, 2019, Blood advances.

Complex with a Collagen-mimetic Peptide 1 I Domain in α The Structure of Integrin Protein Structure and Folding :

P. McEwan, J. Emsley, T. Mulhern, 2013 .

An update on factor XI structure and function.

Chan Li, J. Emsley, I. Verhamme, 2018, Thrombosis research.

Factor XII and kininogen asymmetric assembly with gC1qR/C1QBP/P32 is governed by allostery.

J. Emsley, I. Dreveny, K. McCrae, 2020, Blood.

FXa variants advance toward a therapy for bleeding.

J. Emsley, 2015, Blood.

Plasma kallikrein's low gear.

J. Emsley, 2020, Blood.

Cell Receptor and Cofactor Interactions of the Contact Activation System and Factor XI

J. Emsley, M. Pathak, Alexandre Slater, 2018, Front. Med..

The mechanism underlying activation of factor IX by factor XIa.

J. Emsley, I. Verhamme, S. P. Bajaj, 2014, Thrombosis research.

Nomenclature of factor XI and the contact system

T. Renné, A. Schmaier, C. Maas, 2019, Journal of thrombosis and haemostasis : JTH.

Platelet-Type von Willebrand Disease: New Insights into the Molecular Pathophysiology of a Unique Platelet Defect

J. Emsley, M. Othman, Harmanpreet Kaur, 2013, Seminars in Thrombosis & Hemostasis.

Factor XI Interacts with the Leucine-rich Repeats of Glycoprotein Ibα on the Activated Platelet*

P. Walsh, J. Emsley, F. Baglia, 2004, Journal of Biological Chemistry.

Structural and dynamic characterization of a vinculin binding site in the talin rod.

H. Steinhoff, G. Roberts, J. Emsley, 2006, Biochemistry.

Improving the understanding of plasma kallikrein contribution to arterial thrombus formation using two plant protease inhibitors

J. Emsley, C. Frost, R. Naudé, 2019, Platelets.

Assignments of human integrin α1I domain in the apo and Mg2+ bound states

J. Emsley, M. Scanlon, B. Mohanty, 2014, Biomolecular NMR assignments.

Structure of the Integrin α2β1-binding Collagen Peptide

Richard W. Farndale, J. Emsley, R. Farndale, 2004 .

Structure of the integrin alpha2beta1-binding collagen peptide.

Richard W Farndale, J. Emsley, R. Farndale, 2004, Journal of molecular biology.

Structural Basis of Collagen Recognition by Integrin α2β1

Richard W. Farndale, Robert C. Liddington, R. Liddington, 2000, Cell.

Structural basis of collagen recognition by integrin alpha2beta1.

R. Liddington, J. Emsley, R. Farndale, 2000, Cell.

Staphylococcus aureus protein A binding to von Willebrand factor A1 domain is mediated by conserved IgG binding regions

J. Emsley, G. Silverman, T. Foster, 2006, The FEBS journal.

Plasma kallikrein structure reveals apple domain disc rotated conformation compared to factor XI

Chan Li, J. Emsley, I. Dreveny, 2019, Journal of thrombosis and haemostasis : JTH.

Structure of plasma and tissue kallikreins

J. Emsley, I. Dreveny, M. Pathak, 2013, Thrombosis and Haemostasis.

Mapping the Collagen-binding Site in the I Domain of the Glycoprotein Ia/IIa (Integrin α2β1)*

R. Liddington, J. Emsley, L. Bankston, 2000, The Journal of Biological Chemistry.

Glycoprotein Ibalpha inhibitor complex structure reveals a combined steric and allosteric mechanism of von Willebrand factor antagonism.

P. McEwan, J. Emsley, R. Andrews, 2009, Blood.

Thrombin in the Activation of the Fluid Contact Phase in Patients with Hereditary Angioedema Carrying the F12 P.Thr309Lys Variant

M. López-Trascasa, J. Emsley, J. Corral, 2021, Clinical Reviews in Allergy & Immunology.

The FXII c.-4T>C Polymorphism as a Disease Modifier in Patients With Hereditary Angioedema Due to the FXII p.Thr328Lys Variant

M. López-Trascasa, J. Emsley, J. Corral, 2020, Frontiers in Genetics.

Factor XII in PMM2-CDG patients: role of N-glycosylation in the secretion and function of the first element of the contact pathway

J. Emsley, J. Corral, V. Vicente, 2020, Orphanet Journal of Rare Diseases.

Proteolytic activity of contact factor zymogens

J. Emsley, D. Gailani, A. Shamanaev, 2020, Journal of thrombosis and haemostasis : JTH.

Crystal structure of the factor XI zymogen reveals a pathway for transactivation

P. McEwan, P. Walsh, J. Emsley, 2006, Nature Structural &Molecular Biology.

Activity of factor XII‐Locarno

J. Emsley, B. Mohammed, D. Gailani, 2017, Research and practice in thrombosis and haemostasis.

The structure of the deubiquitinase USP15 reveals a misaligned catalytic triad and an open ubiquitin-binding channel

J. Emsley, I. Dreveny, S. Caulton, 2018, The Journal of Biological Chemistry.

Structural insights into the targeting of mRNA GU-rich elements by the three RRMs of CELF1

J. Emsley, M. Searle, Mark S. Searle, 2013, Nucleic acids research.

Structural insights into the targeting of mRNA GU-rich elements by the three RRMs of CELF 1

J. Emsley, M. Searle, C. H. Moor, 2013 .

Sequence determinants for the tandem recognition of UGU and CUG rich RNA elements by the two N—terminal RRMs of CELF1

J. Emsley, M. Searle, A. Kondrashov, 2011, Nucleic acids research.

Hit Identification of New Potent PqsR Antagonists as Inhibitors of Quorum Sensing in Planktonic and Biofilm Grown Pseudomonas aeruginosa

Christel A. S. Bergström, Shailesh N Mistry, I. Kukavica-Ibrulj, 2020, Frontiers in Chemistry.

Chen, Jianchung and Zhou, Hairu and Diacovo, Alexander and Zheng, X. Long and Emsley, Jonas and Diacovo, Thomas G. (2014) Exploiting the kinetic interplay between GPIb -VWF binding interfaces

T. Diacovo, J. Emsley, Jianchun Chen, 2018 .

Exploiting the kinetic interplay between GPIbα-VWF binding interfaces to regulate hemostasis and thrombosis.

T. Diacovo, J. Emsley, Jianchun Chen, 2014, Blood.

Mapping the Glycoprotein Ib-binding Site in the von Willebrand Factor A1 Domain*

R. Liddington, T. Diacovo, J. Emsley, 2000, The Journal of Biological Chemistry.

Activation of von Willebrand factor via mechanical unfolding of its discontinuous autoinhibitory module

J. Emsley, Renhao Li, E. R. Legan, 2021, Nature Communications.

The importance of vicinal cysteines, C1669 and C1670, for von Willebrand factor A2 domain function.

J. Emsley, D. Lane, J. Crawley, 2010, Blood.

Leucine-rich repeat protein PRAME: expression, potential functions and clinical implications for leukaemia

P. McEwan, J. Emsley, K. Spriggs, 2010, Molecular Cancer.

Binding of platelet glycoprotein Ibβ through the convex surface of leucine‐rich repeats domain of glycoprotein IX

P. McEwan, J. Emsley, X. Mo, 2009, Journal of thrombosis and haemostasis : JTH.

Comparative analyses of pentraxins: implications for protomer assembly and ligand binding.

T. Blundell, N. Srinivasan, J. Emsley, 1995, Structure.

Mapping and Consensus Sequence Identification for Multiple Vinculin Binding Sites within the Talin Rod*

Alexandre R Gingras, Gordon C K Roberts, Igor L Barsukov, 2005, Journal of Biological Chemistry.

Structural Determinants of Integrin Binding to the Talin Rod*S⃞

R. Liddington, M. Joyce, G. Roberts, 2009, Journal of Biological Chemistry.

Activation of a vinculin‐binding site in the talin rod involves rearrangement of a five‐helix bundle

Neil Bate, Ronald Frank, Bipin Patel, 2004 .

Structure of human thioredoxin exhibits a large conformational change

J. Emsley, G. Hall, 2010, Protein science : a publication of the Protein Society.

Echovirus 1 interaction with the human very late antigen-2 (integrin alpha2beta1) I domain. Identification of two independent virus contact sites distinct from the metal ion-dependent adhesion site.

R. Liddington, J. Emsley, Y. Takada, 1997, The Journal of biological chemistry.

Structural assessment of SARS-CoV2 accessory protein ORF7a predicts LFA-1 and Mac-1 binding potential

D. Bates, J. Emsley, K. Arkill, 2020, Bioscience reports.

Ring Structure of the Escherichia coli DNA-binding Protein RdgC Associated with Recombination and Replication Fork Repair*

R. G. Lloyd, P. McEwan, J. Emsley, 2007, Journal of Biological Chemistry.

Structural characterisation of a novel GPVI nanobody-complex reveals a biologically active domain-swapped GPVI dimer.

Natalie S. Poulter, S. Watson, J. Emsley, 2021, Blood.

The Structure of Integrin α1I Domain in Complex with a Collagen-mimetic Peptide*

P. McEwan, J. Emsley, T. Mulhern, 2013, The Journal of Biological Chemistry.

Characterizing the binding of glycoprotein VI with nanobody 35 reveals a novel monomeric structure of glycoprotein VI where the conformation of D1+D2 is independent of dimerization.

Natalie S. Poulter, S. Watson, J. Emsley, 2022, Journal of thrombosis and haemostasis : JTH.

Crystal structure of the I domain from integrin alpha2beta1.

R. Liddington, J. Emsley, J. Bergelson, 1997, The Journal of biological chemistry.

Toward a better understanding of factor XI activation

J. Emsley, D. Gailani, 2019, Journal of thrombosis and haemostasis : JTH.

Analysis of the factor XI variant Arg184Gly suggests a structural basis for factor IX binding to factor XIa

J. Emsley, I. Verhamme, S. P. Bajaj, 2013, Journal of thrombosis and haemostasis : JTH.

Evidence against a protein in plasma that is a product of a factor XI mRNA splice variant missing exons 6 and 7.

A. Gruber, J. Emsley, D. Gailani, 2010, Blood.

Structural basis of the leukocyte integrin Mac-1 I-domain interactions with the platelet glycoprotein Ib.

J. Emsley, M. Saleem, M. Searle, 2019, Blood advances.

Molecular modeling of the prekallikrein structure provides insights into high‐molecular‐weight kininogen binding and zymogen activation

P. McEwan, J. Emsley, E. Hooley, 2007, Journal of thrombosis and haemostasis : JTH.

Design and Evaluation of New Quinazolin-4(3H)-one Derived PqsR Antagonists as Quorum Sensing Quenchers in Pseudomonas aeruginosa.

Christel A S Bergstrom, I. Kukavica-Ibrulj, J. Emsley, 2021, ACS infectious diseases.

Plasma Kallikrein as a Forgotten Clotting Factor

J. Emsley, N. Key, H. Philippou, 2023, Seminars in Thrombosis and Hemostasis.

THROMBOSIS AND HEMOSTASIS Exploiting the kinetic interplay between GPIb a – VWF binding interfaces to regulate hemostasis and thrombosis

T. Diacovo, J. Emsley, Jianchun Chen, 2014 .

VWF (von Willebrand Factor) Comes in From the Cold As a Strategy to Improve Platelet Storage.

J. Emsley, 2019, Arteriosclerosis, Thrombosis and Vascular Biology.

Platelet-Type von Willebrand Disease: Toward an Improved Understanding of the “Sticky Situation”

J. Emsley, M. Othman, 2014, Seminars in Thrombosis & Hemostasis.

Structural Rearrangement in an RsmA/CsrA Ortholog of Pseudomonas aeruginosa Creates a Dimeric RNA-Binding Protein, RsmN

Chan Li, R. Kulkarni, J. Emsley, 2013, Structure.

Crystal structures of the recombinant β-factor XIIa protease with bound Thr-Arg and Pro-Arg substrate mimetics.

Chan Li, L. Dekker, P. Fischer, 2019, Acta crystallographica. Section D, Structural biology.

A non‐circulating pool of factor XI associated with glycosaminoglycans in mice

O. McCarty, A. Gruber, J. Emsley, 2019, Journal of thrombosis and haemostasis : JTH.

Crystal structure of ADAMTS13 CUB domains reveals their role in global latency

J. Emsley, K. Vanhoorelbeke, J. Crawley, 2021, Science Advances.

A1 DOMAIN OF VON WILLEBRAND FACTOR

R. Liddington, J. Emsley, R. Handin, 1998 .

Inherited ADAMTS13 mutations associated with Thrombotic Thrombocytopenic Purpura: a short review and update.

J. Emsley, N. Morgan, Zoe Markham-Lee, 2022, Platelets.

A novel D235Y mutation in the GP1BA gene enhances platelet interaction with von Willebrand factor in an Iranian family with platelet-type von Willebrand disease

J. Emsley, M. Jazebi, M. Othman, 2012, Thrombosis and Haemostasis.

Activation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundle.

Alexandre R Gingras, Neil Bate, Gordon C K Roberts, 2004, The EMBO journal.

Structural and functional characterization of PqsBC, a condensing enzyme in the biosynthesis of the Pseudomonas aeruginosa quinolone signal

Chan Li, J. Emsley, I. Dreveny, 2016 .

Conformational analysis and interaction of the Staphylococcus aureus transmembrane peptidase AgrB with its AgrD propeptide substrate

B. Bonev, J. Emsley, P. Williams, 2023, Frontiers in Chemistry.

Factor VIII/VWF complex caught on camera.

J. Emsley, E. Xu, 2021, Blood.

Central Region of Talin Has a Unique Fold That Binds Vinculin and Actin

G. Roberts, J. Emsley, B. Goult, 2010, The Journal of Biological Chemistry.