S. Mangani

Jean-Denis Docquier, S. Mangani, Stefano Mangani, 2018, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.

Structure-Function Relationships of Class D Carbapenemases.

S. Mangani, J. Docquier, 2016, Current drug targets.

Evolution to carbapenem-hydrolyzing activity in noncarbapenemase class D β-lactamase OXA-10 by rational protein design

S. Mangani, G. Rossolini, C. Pozzi, 2011, Proceedings of the National Academy of Sciences.

Iron binding to human heavy-chain ferritin.

S. Mangani, P. Turano, S. Ciambellotti, 2015, Acta crystallographica. Section D, Biological crystallography.

Theoretical and experimental study of DNA helix-coil transition in acidic and alkaline medium.

S. Mangani, P. Orioli, S. Haroutiunian, 1994, Journal of biomolecular structure & dynamics.

Carbonic anhydrase catalyzes cyanamide hydration to urea: is it mimicking the physiological reaction?

C. Supuran, A. Scozzafava, S. Mangani, 1999, JBIC Journal of Biological Inorganic Chemistry.

Carbonic anhydrase activators: X-ray crystallographic and spectroscopic investigations for the interaction of isozymes I and II with histamine.

S Mangani, C. Supuran, A. Scozzafava, 1997, Biochemistry.

Iron Binding in the Ferroxidase Site of Human Mitochondrial Ferritin.

S. Mangani, P. Turano, S. Ciambellotti, 2021, Chemistry.

Iron biomineral growth from the initial nucleation seed in L-ferritin.

S. Mangani, P. Turano, S. Ciambellotti, 2020, Chemistry.

Structural insights into the ferroxidase site of ferritins from higher eukaryotes.

Elizabeth C. Theil, I. Bertini, S. Mangani, 2012, Journal of the American Chemical Society.

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–7

G. Rastelli, P. Fossa, A. Mangoni, 2020, Molecules.

Ferroxidase Activity in Eukaryotic Ferritin is Controlled by Accessory-Iron-Binding Sites in the Catalytic Cavity.

S. Mangani, P. Turano, C. Pozzi, 2016, Chemistry.

Structural investigation of cisplatin-protein interactions: selective platination of His19 in a cuprozinc superoxide dismutase.

A. Casini, V. Calderone, S. Mangani, 2006, Angewandte Chemie.

Evidence of Pyrimethamine and Cycloguanil Analogues as Dual Inhibitors of Trypanosoma brucei Pteridine Reductase and Dihydrofolate Reductase

Maria Paola Costi, S. Mangani, P. Linciano, 2021, Pharmaceuticals.

Profiling of Flavonol Derivatives for the Development of Antitrypanosomatidic Drugs.

Maria Paola Costi, R. Wade, S. Gul, 2016, Journal of medicinal chemistry.

Crystal Structure of the Narrow-Spectrum OXA-46 Class D β-Lactamase: Relationship between Active-Site Lysine Carbamylation and Inhibition by Polycarboxylates

V. Calderone, S. Mangani, G. Rossolini, 2010, Antimicrobial Agents and Chemotherapy.

The nickel site of Bacillus pasteurii UreE, a urease metallo-chaperone, as revealed by metal-binding studies and X-ray absorption spectroscopy.

S. Ciurli, S. Mangani, F. Musiani, 2006, Biochemistry.

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–6

F. J. Luque, R. Capasso, C. Hulme, 2019, Molecules.

Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections.

Maria Paola Costi, Ulrike Wittig, S. Gul, 2019, Journal of medicinal chemistry.

Multitarget, Selective Compound Design Yields Potent Inhibitors of a Kinetoplastid Pteridine Reductase 1

Maria Paola Costi, R. Wade, S. Gul, 2022, Journal of medicinal chemistry.

Identification of the binding modes of N-phenylphthalimides inhibiting bacterial thymidylate synthase through X-ray crystallography screening.

Maria Paola Costi, S. Mangani, L. Cancian, 2011, Journal of medicinal chemistry.

The crystal structure of the monomeric human SOD mutant F50E/G51E/E133Q at atomic resolution. The enzyme mechanism revisited.

M. Ferraroni, I. Bertini, K. Wilson, 1999, Journal of molecular biology.

Evidence of Destabilization of the Human Thymidylate Synthase (hTS) Dimeric Structure Induced by the Interface Mutation Q62R

Maria Paola Costi, S. Mangani, C. Pozzi, 2019, Biomolecules.

Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery

Maria Paola Costi, R. Wade, W. Hunter, 2017, ACS omega.

Crystallographic determination of reduced bovine superoxide dismutase at pH 5.0 and of anion binding to its active site

Bruno Bruni, M. Ferraroni, S. Mangani, 1998, JBIC Journal of Biological Inorganic Chemistry.

X-ray, NMR and molecular dynamics studies on reduced bovine superoxide dismutase: implications for the mechanism.

I. Bertini, C. Luchinat, P. Carloni, 1994, Biochemical and Biophysical Research Communications - BBRC.

Carbonic-anhydrase - An Example of How the Cavity Governs the Reactivity At the Zinc Ion

I. Bertini, C. Luchinat, R. Pierattelli, 1995 .

Protein–protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase

Maria Paola Costi, Daniela Cardinale, Giambattista Guaitoli, 2011, Proceedings of the National Academy of Sciences.

X-ray crystal structures of Enterococcus faecalis thymidylate synthase with folate binding site inhibitors.

S. Mangani, A. Catalano, C. Pozzi, 2016, European journal of medicinal chemistry.

Copper(I)-alkyl sulfide and -cysteine tri-nuclear clusters as models for metallo proteins: a structural density functional analysis

S. Mangani, G. Tamasi, R. Cini, 2012, Journal of biomolecular structure & dynamics.

High-Resolution Crystal Structure of the Subclass B3 Metallo-β-Lactamase BJP-1: Rational Basis for Substrate Specificity and Interaction with Sulfonamides

Jean-Denis Docquier, Vito Calderone, V. Calderone, 2010, Antimicrobial Agents and Chemotherapy.

Comparative mapping of on-targets and off-targets for the discovery of anti-trypanosomatid folate pathway inhibitors.

Francesca Spyrakis, Maria Paola Costi, Rebecca C Wade, 2017, Biochimica et biophysica acta. General subjects.

Solution and Crystal Structure of Cytisine, a Quinolizidine Alkaloid

S. Mangani, J. Phillipson, K. Asres, 1987 .

Anion coordination chemistry. 3. Second-sphere interaction between the complex anions hexacyanoferrate(II) and hexacyanocobaltate(III), with polycharged tetraazamacrocycles. Thermodynamic and single crystal x-ray studies

A. Bianchi, S. Mangani, M. Micheloni, 1988 .

Copper Binding and Redox Activity of α-Synuclein in Membrane-Like Environment

L. Bubacco, S. Mangani, E. Monzani, 2023, Biomolecules.

Crystal structure of the catalytic domain of human matrix metalloproteinase 10.

I. Bertini, C. Luchinat, V. Calderone, 2004, Journal of molecular biology.

X-ray structures of binary and ternary enzyme-product-inhibitor complexes of matrix metalloproteinases.

I. Bertini, C. Luchinat, V. Calderone, 2003, Angewandte Chemie.

Crystal Structure of the Pseudomonas aeruginosa BEL-1 Extended-Spectrum β-Lactamase and Its Complexes with Moxalactam and Imipenem

P. Nordmann, L. Poirel, S. Mangani, 2016, Antimicrobial Agents and Chemotherapy.

Crystallographic studies of the binding of protonated and unprotonated inhibitors to carbonic anhydrase using hydrogen sulphide and nitrate anions.

S. Mangani, K. Håkansson, 1994, European Journal of Biochemistry.

The structure of the human glutaminyl cyclase–SEN177 complex indicates routes for developing new potent inhibitors as possible agents for the treatment of neurological disorders

S. Mangani, C. Pozzi, M. Benvenuti, 2018, JBIC Journal of Biological Inorganic Chemistry.

Structural insights into the catalytic mechanism of the bacterial class B phosphatase AphA belonging to the DDDD superfamily of phosphohydrolases.

S. Mangani, M. Thaller, M. Benvenuti, 2008, Journal of molecular biology.

2'-Deoxyuridine 5'-monophosphate substrate displacement in thymidylate synthase through 6-hydroxy-2H-naphtho[1,8-bc]furan-2-one derivatives.

Maria Paola Costi, S. Mangani, L. Costantino, 2013, Journal of medicinal chemistry.

A prokaryotic superoxide dismutase paralog lacking two Cu ligands: from largely unstructured in solution to ordered in the crystal.

I. Bertini, A. Quattrone, L. Banci, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Repurposing the Trypanosomatidic GSK Kinetobox for the Inhibition of Parasitic Pteridine and Dihydrofolate Reductases

Maria Paola Costi, F. Spyrakis, S. Mangani, 2021, Pharmaceuticals.

Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth

E. Giovannetti, G. Peters, R. Wade, 2022, eLife.

Structural Comparison of Enterococcus faecalis and Human Thymidylate Synthase Complexes with the Substrate dUMP and Its Analogue FdUMP Provides Hints about Enzyme Conformational Variabilities

Maria Paola Costi, S. Mangani, C. Pozzi, 2019, Molecules.

EXAFS investigation on the iron(III) binding sites of hen phosvitin

E. Stern, A. Scozzafava, S. Mangani, 1990 .

EXAFS studies of Fe(III)-phosvitin at high metal to protein ratios

A. Scozzafava, P. Carloni, S. Mangani, 1994, Biometals.

EXAFS studies on the oxalate adduct of iron transferrin

S. Mangani, L. Messori, 1992 .

Report on the activity of the GILDA-CRG beamline 2009-2013

A. Trapananti, F. d’Acapito, S. Mangani, 2015 .

Dynamic properties of bovine Cu,Zn superoxide dismutase from crystallographic data

S. Mangani, Luca Parri, 1998 .

Identification of phosphate-containing compounds as new inhibitors of 14-3-3/c-Abl protein-protein interaction.

A. Angelucci, M. Botta, M. Mori, 2020, ACS Chemical Biology.

Crystal structure of the complex between carboxypeptidase A and the biproduct analog inhibitor L-benzylsuccinate at 2.0 A resolution.

S Mangani, S. Mangani, P. Orioli, 1992, Journal of molecular biology.

The structure of Enterococcus faecalis thymidylate synthase provides clues about folate bacterial metabolism.

Maria Paola Costi, R. Stroud, S. Mangani, 2012, Acta crystallographica. Section D, Biological crystallography.

The discovery of aryl-2-nitroethyl triamino pyrimidines as anti-Trypanosoma brucei agents.

S. Mangani, M. Costi, P. Linciano, 2023, European journal of medicinal chemistry.

Crystal structure of the ternary complex of Leishmania major pteridine reductase 1 with the cofactor NADP+/NADPH and the substrate folic acid

S. Mangani, L. Dello Iacono, F. Di Pisa, 2022, Acta Crystallographica Section F Structural Biology Communications.

Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery

Ulrike Wittig, S. Mangani, V. Hannaert, 2017, ACS omega.

Biochemical characterization of the class B acid phosphatase (AphA) of Escherichia coli MG1655.

V. Micheli, S. Mangani, C. Passariello, 2006, Biochimica et biophysica acta.

A structure-based proposal for the catalytic mechanism of the bacterial acid phosphatase AphA belonging to the DDDD superfamily of phosphohydrolases.

V. Calderone, S. Mangani, M. Thaller, 2006, Journal of molecular biology.

The first structure of a bacterial class B Acid phosphatase reveals further structural heterogeneity among phosphatases of the haloacid dehalogenase fold.

Vito Calderone, V. Calderone, S. Mangani, 2004, Journal of molecular biology.

Time-lapse anomalous X-ray diffraction shows how Fe(2+) substrate ions move through ferritin protein nanocages to oxidoreductase sites.

S. Mangani, D. Lalli, C. Rosa, 2015, Acta crystallographica. Section D, Biological crystallography.

Differences in the binding of copper(I) to α- and β-synuclein.

L. Bubacco, S. Mangani, L. Casella, 2015, Inorganic chemistry.

High-resolution structure of the complex between carboxypeptidase A and L-phenyl lactate.

S Mangani, K S Wilson, K. Wilson, 1993, Acta crystallographica. Section D, Biological crystallography.