H. Broughton

发表

Structural analysis of inositol monophosphatase complexes with substrates.

J. Springer, R. Bone, L. Frank, 1994, Biochemistry.

A Binding Site on IL-17A for Inhibitory Macrocycles Revealed by Hydrogen/Deuterium Exchange Mass Spectrometry.

Alfonso Espada, M. J. Chalmers, J. Dodge, 2016, Journal of medicinal chemistry.

Macrocyclic peptidomimetic inhibitors of beta-secretase (BACE): first X-ray structure of a macrocyclic peptidomimetic-BACE complex.

D. Timm, H. Broughton, Hsiu-Chiung Yang, 2006, Bioorganic & medicinal chemistry letters.

Molecular Binding Interactions: Their Estimation and Rationalization in QSARs in Terms of Theoretically Derived Parameters

D. Lewis, H. Broughton, 2002, TheScientificWorldJournal.

Molecular Binding Interactions: Their Estimation and Rationalization in QSARs in Terms of Theoretically Derived Parameters

D. Lewis, H. Broughton, 2002, TheScientificWorldJournal.

Controlled modification of acidity in cholecystokinin B receptor antagonists: N-(1,4-benzodiazepin-3-yl)-N'-[3-(tetrazol-5-ylamino) phenyl]ureas.

H. Broughton, V. Matassa, R. Ball, 1996, Journal of medicinal chemistry.

Conformational features of secondary N-cyclopropyl amides.

H. Broughton, Angela Gonzalez‐de‐Castro, J. Martínez-Pérez, 2015, The Journal of organic chemistry.

Integration of phage and yeast display platforms: A reliable and cost effective approach for binning of peptides as displayed on-phage

Y. Qian, H. Broughton, J. J. Carrillo, 2020, PloS one.

Prediction of the histidine-95 pKa perturbation in triosephosphate isomerase using an electrostatically trained neural network (SONNIC)

H. Rzepa, H. Broughton, S. Green, 1992 .

Novel oxathiazinones as gastrin ligands : Unexpected preducts from the schotten-baumann reaction of arylsulphonyl chlorides with derivatives of aspartic acid

C. Low, H. Broughton, I. M. Mcdonald, 1992 .

Fluorination of 3-(3-(piperidin-1-yl)propyl)indoles and 3-(3-(piperazin-1-yl)propyl)indoles gives selective human 5-HT1D receptor ligands with improved pharmacokinetic profiles.

A. Pike, H. Broughton, I. Collins, 1999, Journal of medicinal chemistry.

2-NAP: a selective, hydrophilic, non-peptide CCKA - receptor antagonist derived from the cholecystokinin C-terminal dipeptide.

M. Bodkin, C. Low, H. Broughton, 1993 .

A novel phage display vector for selection of target-specific peptides.

H. Broughton, J. Ting, S. Afshar, 2020, Protein engineering, design & selection : PEDS.

Chemistry of sulfones: synthesis of a new chiral nucleophilic catalyst

H. Broughton, M. Gil, J. G. Urones, 2005 .

Modified CoMFA methods for the analysis of antineoplastic effects of lignan analogues

H. Broughton, M. Gordaliza, M. Castro, 2000 .

Two-Site Evaluation of the Repeatability and Precision of an Automated Dual-Column Hydrogen/Deuterium Exchange Mass Spectrometry Platform.

M. J. Chalmers, P. Griffin, J. Dodge, 2016, Analytical chemistry.

MAVEN: An R/Shiny app for compound mechanism of action analysis and visualisation using transcriptomics and compound structure data

A. Bender, H. Broughton, Layla Hosseini-Gerami, 2022, bioRxiv.

X-ray crystallographic structure determination of detigloyldihydroazadirachtin and reassignment of the structure of the limonoid insect antifeedant azadirachtin

David J. Williams, E. Morgan, A. Slawin, 1986 .

Deciphering Binding Interactions of IL-23R with HDX-MS: Mapping Protein and Macrocyclic Dodecapeptide Ligands.

M. J. Chalmers, Y. Qian, J. Dodge, 2018, ACS medicinal chemistry letters.

A direct conversion of unprotected D-ribose into showdomycin and epishowdomycin

H. Broughton, A. Barrett, 1984 .

Development of peptide 3D structure mimetics: rational design of novel peptoid cholecystokinin receptor antagonists.

J. Black, C. Low, H. Broughton, 2000, Journal of medicinal chemistry.

Crystal structure of active CDK4-cyclin D and mechanistic basis for abemaciclib efficacy

J. Benach, H. Broughton, C. Rauch, 2022, npj Breast Cancer.

3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor.

P D Leeson, P. Leeson, C. Ragan, 1996, Journal of medicinal chemistry.

Synthesis of tri- and tetracyclic diterpenes. Cyclisations promoted by SmI2

H. Broughton, J. G. Urones, D. Díez, 2005 .

A Residue-Resolved Bayesian Approach to Quantitative Interpretation of Hydrogen-Deuterium Exchange from Mass Spectrometry: Application to Characterizing Protein-Ligand Interactions.

Andrej Sali, Christine Humblet, Alfonso Espada, 2017, The journal of physical chemistry. B.

The synthesis of azadirachtin: a potent insect antifeedant.

D. Jennens, M. Göbel, A. Wood, 2008, Chemistry.

4-Heterocyclylpiperidines as selective high-affinity ligands at the human dopamine D4 receptor.

P D Leeson, P. Leeson, C. Ragan, 1997, Journal of medicinal chemistry.

5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl)piperidin-4-yl)isoxazole: a potent, selective antagonist at human cloned dopamine D4 receptors.

P. Leeson, C. Ragan, H. Broughton, 1996, Journal of medicinal chemistry.

N-Arylsulfonylindole derivatives as serotonin 5-HT(6) receptor ligands.

M. Knowles, G. Mcallister, H. Broughton, 2001, Journal of medicinal chemistry.

Organocatalytic Synthesis of an Alkyltetrahydropyran

H. Broughton, J. G. Urones, M. G. Núñez, 2009 .

A new class of chiral pyrrolidine for asymmetric Michael addition reactions. New mechanism via simple 4+2 type attack of the enamine on the trans-nitrostyrene

H. Broughton, M. Gil, J. G. Urones, 2007 .

6,7-Dihydro-2-benzothiophen-4(5H)-ones: a novel class of GABA-A alpha5 receptor inverse agonists.

G. Dawson, J. Atack, H. Broughton, 2002, Journal of medicinal chemistry.

Selection of heterocycles for drug design.

Ian A. Watson, Ian A Watson, H. Broughton, 2004, Journal of molecular graphics & modelling.

New selective cytotoxic diterpenylquinones and diterpenylhydroquinones.

H. Broughton, M. Gordaliza, M. D. García-Grávalos, 2001, Journal of medicinal chemistry.

Vinylsulfones versus alkylsulfones in the addition to chiral imines. Synthesis of N-(tert-butoxycarbonyl)-l-homophenylalanine

H. Broughton, J. G. Urones, D. Díez, 2005 .

Chemistry of allylsulfones: A new preparation of N-diphenylmethylene-2-vinyl-substituted cyclopropylamines

H. Broughton, J. G. Urones, D. Díez, 2004 .

Synthesis, biological activity and electrostatic properties of 3-[2-(dimethylamino)ethyl]-5-[(3-amino-1,2,4-thiadiazol-5-yl)methyl]-1H-indole, a novel 5-HT1D receptor agonist.

H. Broughton, V. Matassa, R. Mosley, 1993 .

Chemistry of epoxysulfones: straightforward synthesis of versatile chiral building blocks.

H. Broughton, J. G. Urones, D. Díez, 2003, Organic letters.

Preparation and cytotoxicity of podophyllotoxin derivatives lacking the lactone ring

H. Broughton, M. Gordaliza, P. A. García, 1997 .

Electrostatic vs. orbital control in π-facial diasteroselection: a PM3 SCF-MO study of electrophilic reactivity in 7-methylenenorbornanes

H. Rzepa, H. Broughton, S. Green, 1992 .

Chemistry of insect antifeedants from (part 2): Synthesis of a polyoxygenated decalin with limonoid structural homology.

S. Ley, H. Broughton, M. Brasca, 1988 .

Vinylsulfones as nucleophiles and michael acceptors in the same step : Stereoselective synthesis of amino acid precursors

H. Broughton, J. G. Urones, D. Díez, 2005 .

Chemistry of vinyl sulfones. Approach to novel conformationally restricted analogues of glutamic acid

H. Broughton, J. G. Urones, D. Díez, 2005 .

Stereocontrolled synthesis of cyclopropanol amino acids from allylic sulfones: conformationally restricted building blocks.

H. Broughton, J. G. Urones, D. Díez, 2003, Organic letters.

Two total syntheses of showdomycin and related studies

H. Broughton, A. Barrett, A. Gunatilaka, 1986 .

A semiempirical SCF-MO study of the tautomeric forms of 3-acetyl tetronic- and tetramic acids

Howard Broughton, P. R. Woodward, H. Broughton, 1990, J. Comput. Aided Mol. Des..

Synthesis of 2 -Amino -5 -arylthiazoles by Palladium-Catalyzed Arylation at the C5 Position with Aryl Iodides

H. Broughton, R. Ferritto, J. Priego, 2007 .

Inositol monophosphatase — a putative target for Li+ in the treatment of bipolar disorder

S. Pollack, J. Atack, H. Broughton, 1995, Trends in Neurosciences.

Chemistry of labdanediol from Cistus ladaniferus, L. synthesis of 12-Nor-ambreinolide and α and β-levantenolides

David Diez Martin, H. Broughton, J. G. Urones, 1992 .

Labdanolic Acid: Synthetic Precursor of Tricyclic Diterpenes

H. Broughton, J. G. Urones, D. Díez, 1995 .

Chemistry of insect antifeedants from azadirachta indica (part 4): synthesis towards the limonoid azadirachtin; preparation of a functionalised decalin fragment

David J. Williams, A. Slawin, S. Ley, 1989 .

An x-ray crystallographic, mass spectroscopic, and NMR study of the limonoid insect antifeedant azadirachtin and related derivatives

David J. Williams, E. Morgan, H. Rzepa, 1987 .

Synthesis of bioactive sesterterpenolides from ent-halimic acid. 15-epi-ent-Cladocoran A and B.

H. Broughton, F. Mollinedo, J. G. Urones, 2003, The Journal of organic chemistry.

A Method for the Rapid and Simple Measurement of the Magnitude and Relative Sign of 1H–19F Coupling Constants

H. Broughton, J. Espinosa, 2013 .

Studies of imidazole and pyrazole protonation using electrostatically trained neural networks

H. Rzepa, H. Broughton, S. Green, 1995 .

Utilization of peptide phage display to investigate hotspots on IL-17A and what it means for drug discovery

M. J. Chalmers, S. Wasserman, D. Manglicmot, 2018, PloS one.

Probing the role of metal ions in the mechanism of inositol monophosphatase by site-directed mutagenesis.

S. Pollack, S. Osborne, J. Atack, 1993, European journal of biochemistry.

The chemical basis of serine palmitoyltransferase inhibition by myriocin.

T. Dunn, J. Naismith, P. Langridge-Smith, 2013, Journal of the American Chemical Society.

5-(Piperidin-2-yl)- and 5-(homopiperidin-2-yl)-1,4-benzodiazepines: high-affinity, basic ligands for the cholecystokinin-B receptor.

H. Broughton, V. Matassa, R. Ball, 1997, Journal of medicinal chemistry.

Defining Target Engagement Required for Efficacy In Vivo at the Retinoic Acid Receptor-Related Orphan Receptor C2 (RORγt).

G. Durst, D. Clawson, R. Morphy, 2021, Journal of medicinal chemistry.

Structural reappraisal of the limonoid insect antifeedant azadirachtin

E. Morgan, H. Rzepa, S. Ley, 1985 .

Structural analysis of inositol monophosphatase complexes with substrates.

J. Springer, R. Bone, L. Frank, 1995, Biochemistry.

Bioactive isoxazoline and oxime derivatives from 7-ketolignans

H. Broughton, M. Gordaliza, A. San Feliciano, 1997 .

Structure and mechanism of inositol monophosphatase

S. Pollack, J. Atack, H. Broughton, 1995, FEBS letters.

Mechanism of inositol monophosphatase, the putative target of lithium therapy.

L. L. Iversen, S. Pollack, J. Atack, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Mechanism of action deconvolution of the small-molecule pathological tau aggregation inhibitor Anle138b

D. Airey, H. Broughton, J. Scherschel, 2023, Alzheimer's Research & Therapy.

Identification of a Novel, Selective GABAA α5 Receptor Inverse Agonist Which Enhances Cognition

G. Dawson, J. Atack, H. Broughton, 2003 .

STUDIES ON BICYCLO[3.3.1]NONANES FOR SYNTHESIS OF CYCLOOCTENES

H. Broughton, M. Parra, J. G. Urones, 2002 .

Serine derived NK1 antagonists. 2: A pharmacophore model for arylsulfonamide binding.

H. Broughton, A. Macleod, I. Huscroft, 1998, Bioorganic & medicinal chemistry letters.

A Decoupled Automation Platform for Hydrogen/Deuterium Exchange Mass Spectrometry Experiments

M. J. Chalmers, P. Griffin, J. Dodge, 2019, Journal of The American Society for Mass Spectrometry.

Optimization of Hydroxyethylamine Transition State Isosteres as Aspartic Protease Inhibitors by Exploiting Conformational Preferences.

J. F. Soriano, D. Timm, H. Broughton, 2017, Journal of medicinal chemistry.

Crystal structure of active CDK4-cyclin D and mechanistic basis for abemaciclib efficacy

J. Benach, H. Broughton, C. Rauch, 2022, npj Breast Cancer.

A Perspective of Peptide Modelling

H. Broughton, H. Broughton, 1994 .

FTree query construction for virtual screening: a statistical analysis

Andrea Zaliani, Howard Broughton, Christof Gerlach, 2008, J. Comput. Aided Mol. Des..

A method for including protein flexibility in protein-ligand docking: improving tools for database mining and virtual screening.

H. Broughton, H B Broughton, H. .. Broughton, 2000, Journal of molecular graphics & modelling.

MAVEN: compound mechanism of action analysis and visualisation using transcriptomics and compound structure data in R/Shiny

A. Bender, H. Broughton, Layla Hosseini-Gerami, 2023, BMC Bioinformatics.

High-throughput hydrogen bond strength calculation and its applications in optimizing drug ADME properties.

Ian A. Watson, H. Broughton, P. Desai, 2019, Future medicinal chemistry.

Assignment of absolute configuration on the basis of the conformational effects induced by chiral derivatizing agents: the 2-arylpyrrolidine case.

H. Broughton, Nuria Díaz, C. Pedregal, 2007, Organic letters.

Synthesis and Absolute Configuration of the Supposed Structure of Cladocoran A and B

H. Broughton, J. G. Urones, D. Díez, 2002 .

The chemical basis of serine palmitoyltransferase inhibition by myriocin.

T. Dunn, J. Naismith, P. Langridge-Smith, 2013, Journal of the American Chemical Society.