D. Leonidas

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Crystal structures of ribonuclease A complexes with 5'-diphosphoadenosine 3'-phosphate and 5'-diphosphoadenosine 2'-phosphate at 1.7 A resolution.

K. Acharya, D. Leonidas, R. Shapiro, 1997, Biochemistry.

Structural basis for the recognition of carbohydrates by human galectin-7.

K. Acharya, D. Leonidas, E. Vatzaki, 1998, Biochemistry.

New inhibitors of glycogen phosphorylase as potential antidiabetic agents.

S. Zographos, N. Oikonomakos, D. Leonidas, 2008, Current medicinal chemistry.

Computation as a tool for glycogen phosphorylase inhibitor design.

D. Leonidas, J. Hayes, 2010, Mini reviews in medicinal chemistry.

Influence of naturally-occurring 5′-pyrophosphate-linked substituents on the binding of adenylic inhibitors to ribonuclease a: An X-ray crystallographic study

K. Acharya, D. Leonidas, D. E. Holloway, 2009, Biopolymers.

Oxidation of human serum albumin exhibits inter-individual variability after an ultra-marathon mountain race

D. Spandidos, D. Leonidas, A. Tsatsakis, 2017, Experimental and therapeutic medicine.

Nicotinic cholinergic system and COVID-19: In silico evaluation of nicotinic acetylcholine receptor agonists as potential therapeutic interventions

Georgios E. Papadopoulos, K. Farsalinos, A. Tsatsakis, 2020, Toxicology Reports.

Glucose-based spiro-isoxazolines: a new family of potent glycogen phosphorylase inhibitors.

S. Zographos, N. Oikonomakos, D. Leonidas, 2009, Bioorganic & medicinal chemistry.

The σ‐Hole Phenomenon of Halogen Atoms Forms the Structural Basis of the Strong Inhibitory Potency of C5 Halogen Substituted Glucopyranosyl Nucleosides towards Glycogen Phosphorylase b

S. Zographos, D. Leonidas, A. Psarra, 2012, ChemMedChem.

Non-contact Current Transfer Induces the Formation and Improves the X-ray Diffraction Quality of Protein Crystals

D. Leonidas, G. Lagoumintzis, S. Tzartos, 2014 .

The binding of IMP to Ribonuclease A

N. Oikonomakos, D. Leonidas, J. Kobe, 2005, The FEBS journal.

High‐resolution crystal structures of ribonuclease A complexed with adenylic and uridylic nucleotide inhibitors. Implications for structure‐based design of ribonucleolytic inhibitors

N. Oikonomakos, K. Acharya, D. Leonidas, 2003, Protein science : a publication of the Protein Society.

Toward rational design of ribonuclease inhibitors: high-resolution crystal structure of a ribonuclease A complex with a potent 3',5'-pyrophosphate-linked dinucleotide inhibitor.

K. Acharya, D. Leonidas, R. Shapiro, 1999, Biochemistry.

3′‐Axial CH2OH Substitution on Glucopyranose does not Increase Glycogen Phosphorylase Inhibitory Potency. QM/MM‐PBSA Calculations Suggest Why

D. Leonidas, P. Zoumpoulakis, V. Skamnaki, 2012, Chemical biology & drug design.

Synthetic flavonoid derivatives targeting the glycogen phosphorylase inhibitor site: QM/MM-PBSA motivated synthesis of substituted 5,7-dihydroxyflavones, crystallography, in vitro kinetics and ex-vivo cellular experiments reveal novel potent inhibitors.

T. Snape, D. Leonidas, A. Psarra, 2020, Bioorganic chemistry.

Indirubin and indigo analogues as potential inhibitors of glycogenolysis: structural basis of glycogen phosphorylase inhibition

S. Zographos, N. Oikonomakos, D. Leonidas, 2006 .

X-ray sequence ambiguities of Sclerotium rolfsii lectin resolved by mass spectrometry

D. Leonidas, S. Inamdar, N. Nagaraja, 2008, Amino Acids.

Crystallographic and computational studies on 4‐phenyl‐N‐(β‐D‐glucopyranosyl)‐1H‐1,2,3‐triazole‐1‐acetamide, an inhibitor of glycogen phosphorylase: Comparison with α‐D‐glucose, N‐acetyl‐β‐D‐glucopyranosylamine and N‐benzoyl‐N′‐β‐D‐glucopyranosyl urea binding

S. Zographos, N. Oikonomakos, D. Leonidas, 2007 .

Mutagenesis of a Lotus japonicus GSK3β/Shaggy-like kinase reveals functionally conserved regulatory residues.

Georgios E. Papadopoulos, D. Leonidas, K. Papadopoulou, 2021, Phytochemistry.

The architecture of hydrogen and sulfur σ-hole interactions explain differences in the inhibitory potency of C-β-d-glucopyranosyl thiazoles, imidazoles and an N-β-d glucopyranosyl tetrazole for human liver glycogen phosphorylase and offer new insights to structure-based design.

S. Zographos, D. Leonidas, A. Psarra, 2019, Bioorganic & medicinal chemistry.

Potential interference of aluminum chlorohydrate with estrogen receptor signaling in breast cancer cells.

G. Chrousos, D. Leonidas, A. Psarra, 2018, Journal of molecular biochemistry.

Amide-1,2,3-triazole bioisosterism: the glycogen phosphorylase case

S. Zographos, N. Oikonomakos, D. Leonidas, 2009 .

Bioactivity of glycogen phosphorylase inhibitors that bind to the purine nucleoside site.

N. Oikonomakos, D. Leonidas, C. Tiraidis, 2006, Bioorganic & medicinal chemistry.

The design of potential antidiabetic drugs: experimental investigation of a number of β-D-glucose analogue inhibitors of glycogen phosphorylase

L. Johnson, C. Bichard, E. Mitchell, 1994, European Journal of Drug Metabolism and Pharmacokinetics.

A multidisciplinary study of 3-(β-d-glucopyranosyl)-5-substituted-1,2,4-triazole derivatives as glycogen phosphorylase inhibitors: Computation, synthesis, crystallography and kinetics reveal new potent inhibitors.

D. Leonidas, G. Stravodimos, L. Somsák, 2018, European journal of medicinal chemistry.

Glucopyranosylidene-spiro-imidazolinones, a New Ring System: Synthesis and Evaluation as Glycogen Phosphorylase Inhibitors by Enzyme Kinetics and X-ray Crystallography.

S. Zographos, D. Leonidas, A. Psarra, 2019, Journal of medicinal chemistry.

Crystallization and preliminary investigations on a telomeric repeat sequence C4A2C4A2.

K. Acharya, D. Leonidas, M. Viswamitra, 2001, Acta crystallographica. Section D, Biological crystallography.

Crystallization and preliminary X-ray crystallographic analysis of Sclerotium rolfsii lectin.

N. Oikonomakos, D. Leonidas, S. Inamdar, 2003, Acta crystallographica. Section D, Biological crystallography.

Triazole pyrimidine nucleosides as inhibitors of Ribonuclease A. Synthesis, biochemical, and structural evaluation.

D. Leonidas, A. Kantsadi, S. Manta, 2012, Bioorganic & medicinal chemistry.

NMR study of Met-1 human Angiogenin: 1H, 13C, 15N backbone and side-chain resonance assignment

D. Leonidas, G. Spyroulias, A. C. Tsika, 2016, Biomolecular NMR assignments.

Inhibition of rabbit muscle glycogen phosphorylase by D-gluconohydroximo-1,5-lactone-N-phenylurethane.

N. Oikonomakos, D. Leonidas, A. Papageorgiou, 1989, Archives of biochemistry and biophysics.

The Crystal Structure of Human Placenta Growth Factor-1 (PlGF-1), an Angiogenic Protein, at 2.0 Å Resolution*

G. J. Swaminathan, K. Acharya, D. Leonidas, 2001, The Journal of Biological Chemistry.

Structure activity relationship of the binding of p-coumaroyl glucose to glycogen phosphorylase and its effect on hepatic cell metabolic pathways

D. Leonidas, A. Psarra, A. Tsagkarakou, 2021, European Journal of Medicinal Chemistry Reports.

Kinetic and crystallographic studies on 2‐(β‐D‐glucopyranosyl)‐5‐methyl‐1, 3, 4‐oxadiazole, ‐benzothiazole, and ‐benzimidazole, inhibitors of muscle glycogen phosphorylase b. Evidence for a new binding site

N. Oikonomakos, D. Leonidas, L. Somsák, 2005, Protein science : a publication of the Protein Society.

The binding of β-d-glucopyranosyl-thiosemicarbazone derivatives to glycogen phosphorylase: A new class of inhibitors.

S. Zographos, N. Oikonomakos, D. Leonidas, 2010, Bioorganic & medicinal chemistry.

In the search of glycogen phosphorylase inhibitors : Synthesis of C-D-glycopyranosylbenzo (hydro )quinones-inhibition of and binding to glycogen phosphorylase in the crystal

N. Oikonomakos, D. Leonidas, E. Chrysina, 2007 .

Control of phosphorylase b conformation by a modified cofactor: Crystallographic studies on R‐state glycogen phosphorylase reconstituted with pyridoxal 5′‐diphosphate

L. Johnson, D. Barford, N. Oikonomakos, 1992, Protein science : a publication of the Protein Society.

Binding of beta-D-glucopyranosyl bismethoxyphosphoramidate to glycogen phosphorylase b: kinetic and crystallographic studies.

N. Oikonomakos, D. Leonidas, E. Chrysina, 2005, Bioorganic & medicinal chemistry.

The binding of C5-alkynyl and alkylfurano[2,3-d]pyrimidine glucopyranonucleosides to glycogen phosphorylase b: synthesis, biochemical and biological assessment.

S. Zographos, D. Leonidas, A. Psarra, 2012, European journal of medicinal chemistry.

1-(3-Deoxy-3-fluoro-beta-d-glucopyranosyl) pyrimidine derivatives as inhibitors of glycogen phosphorylase b: Kinetic, crystallographic and modelling studies.

S. Zographos, D. Leonidas, V. G. Tsirkone, 2010, Bioorganic & medicinal chemistry.

Synthetic, enzyme kinetic, and protein crystallographic studies of C-β-d-glucopyranosyl pyrroles and imidazoles reveal and explain low nanomolar inhibition of human liver glycogen phosphorylase.

D. Leonidas, G. Batta, G. Stravodimos, 2016, European journal of medicinal chemistry.

Design of inhibitors of glycogen phosphorylase: a study of alpha- and beta-C-glucosides and 1-thio-beta-D-glucose compounds.

L. Johnson, C. Bichard, E. Mitchell, 1994, Biochemistry.

The ammonium sulfate activation of phosphorylase b

N. Oikonomakos, D. Leonidas, A. Papageorgiou, 1990, FEBS letters.

Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies.

S. Zographos, N. Oikonomakos, D. Leonidas, 2008, Journal of medicinal chemistry.

Crystal Structure of the Eosinophil Major Basic Protein at 1.8 Å

G. J. Swaminathan, D. Loegering, K. Acharya, 2001, Journal of Biological Chemistry.

Natural products and their derivatives as inhibitors of glycogen phosphorylase: potential treatment for type 2 diabetes

D. Leonidas, J. Hayes, A. Kantsadi, 2014, Phytochemistry Reviews.

Anopheles gambiae odorant binding protein crystal complex with the synthetic repellent DEET: implications for structure-based design of novel mosquito repellents

S. Zographos, T. Thireou, D. Leonidas, 2011, Cellular and Molecular Life Sciences.

Iminosugars as potential inhibitors of glycogenolysis: structural insights into the molecular basis of glycogen phosphorylase inhibition.

S. Zographos, N. Oikonomakos, D. Leonidas, 2006, Journal of medicinal chemistry.

Nanomolar Inhibitors of Glycogen Phosphorylase Based on β-d-Glucosaminyl Heterocycles: A Combined Synthetic, Enzyme Kinetic, and Protein Crystallography Study.

S. Zographos, D. Leonidas, G. Stravodimos, 2017, Journal of medicinal chemistry.

Crystallographic Studies on α- and β-D-glucopyranosyl Formamide Analogues, Inhibitors of Glycogen Phosphorylase

Spyros E. Zographos, S. Zographos, N. Oikonomakos, 2003 .

Triazole double-headed ribonucleosides as inhibitors of eosinophil derived neurotoxin.

E. Boix, D. Leonidas, A. Kantsadi, 2015, Bioorganic chemistry.

Biochemical and in silico identification of the active site and the catalytic mechanism of the circadian deadenylase HESPERIN

D. Leonidas, D. Vlachakis, N. Balatsos, 2020, FEBS open bio.

AtHESPERIN: a novel regulator of circadian rhythms with poly(A)-degrading activity in plants

D. Leonidas, A. Tomatsidou, K. Papadopoulou, 2016, RNA biology.

Crystallographic studies on two bioisosteric analogues, N-acetyl-beta-D-glucopyranosylamine and N-trifluoroacetyl-beta-D-glucopyranosylamine, potent inhibitors of muscle glycogen phosphorylase.

Evangelia D Chrysina, S. Zographos, N. Oikonomakos, 2005, Bioorganic & medicinal chemistry.

Mapping the ribonucleolytic active site of bovine seminal ribonuclease. The binding of pyrimidinyl phosphonucleotide inhibitors.

S. Zographos, D. Leonidas, J. Matoušek, 2009, European journal of medicinal chemistry.

N-(4-Substituted-benzoyl)-N'-(β-d-glucopyranosyl)ureas as inhibitors of glycogen phosphorylase: Synthesis and evaluation by kinetic, crystallographic, and molecular modelling methods.

S. Zographos, N. Oikonomakos, D. Leonidas, 2012, Bioorganic & Medicinal Chemistry.

Molecular Cloning, Carbohydrate Specificity and the Crystal Structure of Two Sclerotium rolfsii Lectin Variants

D. Leonidas, S. Eligar, S. Inamdar, 2015, Molecules.

Structural basis for the carbohydrate recognition of the Sclerotium rolfsii lectin.

S. Zographos, N. Oikonomakos, D. Leonidas, 2007, Journal of molecular biology.

Biochemical and biological assessment of the inhibitory potency of extracts from vinification byproducts of Vitis vinifera extracts against glycogen phosphorylase.

D. Leonidas, S. Haroutounian, D. Kouretas, 2014, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

The crystal structure of the Fab fragment of a rat monoclonal antibody against the main immunogenic region of the human muscle acetylcholine receptor.

N. Oikonomakos, K. Acharya, D. Leonidas, 1999, European journal of biochemistry.

Charcot-Leyden Crystal Protein (Galectin-10) Is Not a Dual Function Galectin with Lysophospholipase Activity but Binds a Lysophospholipase Inhibitor in a Novel Structural Fashion*

G. J. Swaminathan, K. Acharya, D. Leonidas, 2002, The Journal of Biological Chemistry.

Crystal structure of a hybrid between ribonuclease A and bovine seminal ribonuclease--the basic surface, at 2.0 A resolution.

S. Benner, J. Stackhouse, K. Acharya, 1999, European journal of biochemistry.

Refined crystal structures of native human angiogenin and two active site variants: implications for the unique functional properties of an enzyme involved in neovascularisation during tumour growth.

K. Acharya, D. Leonidas, R. Shapiro, 1999, Journal of molecular biology.

Crystal structure of human Charcot-Leyden crystal protein, an eosinophil lysophospholipase, identifies it as a new member of the carbohydrate-binding family of galectins.

K. Acharya, D. Leonidas, S. Ackerman, 1995, Structure.

The ammonium sulfate inhibition of human angiogenin

D. Leonidas, G. Stravodimos, A. Kantsadi, 2016, FEBS letters.

Sourcing the affinity of flavonoids for the glycogen phosphorylase inhibitor site via crystallography, kinetics and QM/MM-PBSA binding studies: comparison of chrysin and flavopiridol.

S. Zographos, N. Oikonomakos, D. Leonidas, 2013, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Kinetic properties of tetrameric glycogen phosphorylase b in solution and in the crystalline state

D. Leonidas, A. Papageorgiou, T. Sotiroudis, 1992, Protein science : a publication of the Protein Society.

The binding of β‐ and γ‐cyclodextrins to glycogen phosphorylase b: Kinetic and crystallographic studies

N. Oikonomakos, D. Leonidas, E. Chrysina, 2003, Protein science : a publication of the Protein Society.

Nicotinic Cholinergic System and COVID-19: In Silico Identification of an Interaction between SARS-CoV-2 and Nicotinic Receptors with Potential Therapeutic Targeting Implications

Georgios E. Papadopoulos, K. Farsalinos, D. Leonidas, 2020, International journal of molecular sciences.

NMR study of Met-1 human Angiogenin: 1H, 13C, 15N backbone and side-chain resonance assignment

D. Leonidas, G. Spyroulias, A. C. Tsika, 2016, Biomolecular NMR Assignments.

Structural Studies on Angiogenin, a Protein Implicated in Neovascularization during Tumour Growth

K. Acharya, D. Leonidas, N. Russo, 1998 .

Structural analysis of the Rhizoctonia solani agglutinin reveals a domain‐swapping dimeric assembly

W. Nierman, S. Pakala, D. Leonidas, 2013, The FEBS journal.

The structure of AgamOBP5 in complex with the natural insect repellents Carvacrol and Thymol: Crystallographic, fluorescence and thermodynamic binding studies.

S. Zographos, D. Fessas, D. Leonidas, 2023, International journal of biological macromolecules.

Affinity crystallography reveals binding of pomegranate juice anthocyanins at the inhibitor site of glycogen phosphorylase: the contribution of sugar moiety to potency and its implications to binding mode.

D. Leonidas, A. Psarra, A. Tsagkarakou, 2020, Journal of agricultural and food chemistry.

The druggability of the ATP binding site of glycogen phosphorylase kinase probed by coumarin analogues

D. Leonidas, A. Psarra, A. Tsagkarakou, 2022, Current Research in Chemical Biology.

Glycogen phosphorylase revisited: extending the resolution of the R- and T-state structures of the free enzyme and in complex with allosteric activators.

S. Zographos, D. Leonidas, K. Tsitsanou, 2021, Acta crystallographica. Section F, Structural biology communications.

High Consistency of Structure-Based Design and X-Ray Crystallography: Design, Synthesis, Kinetic Evaluation and Crystallographic Binding Mode Determination of Biphenyl-N-acyl-β-d-Glucopyranosylamines as Glycogen Phosphorylase Inhibitors

S. Zographos, D. Leonidas, A. Tsagkarakou, 2019, Molecules.

Probing the β-pocket of the active site of human liver glycogen phosphorylase with 3-(C-β-d-glucopyranosyl)-5-(4-substituted-phenyl)-1, 2, 4-triazole inhibitors.

D. Leonidas, G. Stravodimos, L. Somsák, 2018, Bioorganic chemistry.

Affinity Crystallography Reveals the Bioactive Compounds of Industrial Juicing Byproducts of Punica granatum for Glycogen Phosphorylase.

D. Leonidas, S. Haroutounian, A. Psarra, 2017, Current drug discovery technologies.

Phytogenic Polyphenols as Glycogen Phosphorylase Inhibitors: The Potential of Triterpenes and Flavonoids for Glycaemic Control in Type 2 Diabetes.

D. Leonidas, G. Stravodimos, J. Hayes, 2017, Current medicinal chemistry.

Natural flavonoids as antidiabetic agents. The binding of gallic and ellagic acids to glycogen phosphorylase b

D. Leonidas, G. Stravodimos, A. Kantsadi, 2015, FEBS letters.

Mapping the Ribonucleolytic Active Site of Eosinophil-derived Neurotoxin (EDN)

G. J. Swaminathan, E. Boix, K. Acharya, 2001, The Journal of Biological Chemistry.

hCINAP is an atypical mammalian nuclear adenylate kinase with an ATPase motif: Structural and functional studies

A. Lamond, S. Zographos, N. Oikonomakos, 2012, Proteins.

Proteomic Analysis of Human Angiogenin Interactions Reveals Cytoplasmic PCNA as a Putative Binding Partner.

G. Panayotou, D. Leonidas, A. Alexopoulou, 2017, Journal of proteome research.

Recombinant Human Eosinophil Cationic Protein

E. Boix, K. Acharya, D. Leonidas, 2000 .

van der Waals interactions govern C-β-d-glucopyranosyl triazoles' nM inhibitory potency in human liver glycogen phosphorylase.

D. Leonidas, G. Stravodimos, L. Somsák, 2017, Journal of structural biology.

Crystal structure of rabbit muscle glycogen phosphorylase a in complex with a potential hypoglycaemic drug at 2.0 A resolution.

N. Oikonomakos, D. Leonidas, E. Chrysina, 2002, Biochimica et biophysica acta.

Binding of N‐acetyl‐N ′‐β‐d‐glucopyranosyl urea and N‐benzoyl‐N ′‐β‐d‐glucopyranosyl urea to glycogen phosphorylase b

B. Tóth, S. Zographos, N. Oikonomakos, 2002 .

Binding of N-acetyl-N '-beta-D-glucopyranosyl urea and N-benzoyl-N '-beta-D-glucopyranosyl urea to glycogen phosphorylase b: kinetic and crystallographic studies.

B. Tóth, S. Zographos, N. Oikonomakos, 2002, European journal of biochemistry.

The structure of glycogen phosphorylase b with an alkyldihydropyridine-dicarboxylic acid compound, a novel and potent inhibitor.

L. Johnson, K. Watson, S. Zographos, 1997, Structure.

Sulphate activates phosphorylase b by binding to the Ser (P) site.

N. Oikonomakos, D. Leonidas, A. Papageorgiou, 1991, Biochimica et biophysica acta.

X-Ray and Solution Studies on Glycogen Phosphorylase Reconstituted with Pyridoxal in Place of the Natural Coenzyme

L. Johnson, N. Oikonomakos, D. Leonidas, 1991 .

Recognition of ribonuclease A by 3'-5'-pyrophosphate-linked dinucleotide inhibitors: a molecular dynamics/continuum electrostatics analysis.

N. Oikonomakos, D. Leonidas, G. Archontis, 2007, Biophysical journal.

Structural and Biochemical Characterization of the Human Angiogenin-Proliferating Cell Nuclear Antigen Interaction.

Georgios E. Papadopoulos, G. Kontopidis, D. Leonidas, 2023, Biochemistry.

Crystallographic studies on the role of the C-terminal segment of human angiogenin in defining enzymatic potency.

K. Acharya, D. Leonidas, R. Shapiro, 2002, Biochemistry.

Editorial: Role of Ribonucleases in Immune Response Regulation During Infection and Cancer

F. Acquati, E. Boix, D. Leonidas, 2020, Frontiers in Immunology.

Evidence for Novel Action at the Cell‐Binding Site of Human Angiogenin Revealed by Heteronuclear NMR Spectroscopy, in silico and in vivo Studies

D. Leonidas, J. Hayes, G. Spyroulias, 2018, ChemMedChem.

An evaluation of indirubin analogues as phosphorylase kinase inhibitors.

Alexios-Leandros Skaltsounis, Colin Moffatt, N. Oikonomakos, 2015, Journal of molecular graphics & modelling.

Eosinophil Proteins: Structural biology of Charcot–Leyden crystal protein (Galectin-10): new insights into an old protein☆

G. J. Swaminathan, K. Acharya, D. Leonidas, 2000 .

Multidisciplinary docking, kinetics and X-ray crystallography studies of baicalein acting as a glycogen phosphorylase inhibitor and determination of its' potential against glioblastoma in cellular models.

D. Leonidas, A. Psarra, G. Stravodimos, 2023, Chemico-biological interactions.

The refined crystal structure of toxic shock syndrome toxin-1 at 2.07 A resolution.

K. Acharya, D. Leonidas, A. Papageorgiou, 1996, Journal of molecular biology.

The binding of 3'-N-piperidine-4-carboxyl-3'-deoxy-ara-uridine to ribonuclease A in the crystal.

S. Zographos, N. Oikonomakos, D. Leonidas, 2006, Bioorganic & medicinal chemistry.

Glucopyranosylidene-spiro-iminothiazolidinone, a new bicyclic ring system: synthesis, derivatization, and evaluation for inhibition of glycogen phosphorylase by enzyme kinetic and crystallographic methods.

S. Zographos, D. Leonidas, K. Kövér, 2014, Bioorganic & medicinal chemistry.

Crystal structure of eosinophil cationic protein at 2.4 A resolution.

E. Boix, K. Acharya, M. Nogués, 1999, Biochemistry.

Binding of Phosphate and pyrophosphate ions at the active site of human angiogenin as revealed by X‐ray crystallography

Songlin Li, K. Acharya, D. Leonidas, 2001, Protein science : a publication of the Protein Society.

Natural products and their derivatives as inhibitors of glycogen phosphorylase: potential treatment for type 2 diabetes

D. Leonidas, J. Hayes, A. Kantsadi, 2014, Phytochemistry Reviews.

Binding of the potential antitumour agent indirubin-5-sulphonate at the inhibitor site of rabbit muscle glycogen phosphorylase b. Comparison with ligand binding to pCDK2-cyclin A complex.

Gerhard Eisenbrand, Evangelia D Chrysina, N. Oikonomakos, 2004, European journal of biochemistry.

Halogen-substituted (C-β-D-glucopyranosyl)-hydroquinone regioisomers: synthesis, enzymatic evaluation and their binding to glycogen phosphorylase.

S. Zographos, N. Oikonomakos, D. Leonidas, 2011, Bioorganic & medicinal chemistry.

3′‐Axial CH2OH Substitution on Glucopyranose does not Increase Glycogen Phosphorylase Inhibitory Potency. QM/MM‐PBSA Calculations Suggest Why

D. Leonidas, P. Zoumpoulakis, V. Skamnaki, 2012, Chemical biology & drug design.

The σ‐Hole Phenomenon of Halogen Atoms Forms the Structural Basis of the Strong Inhibitory Potency of C5 Halogen Substituted Glucopyranosyl Nucleosides towards Glycogen Phosphorylase b

S. Zographos, D. Leonidas, A. Psarra, 2012, ChemMedChem.

Structure based inhibitor design targeting glycogen phosphorylase B. Virtual screening, synthesis, biochemical and biological assessment of novel N-acyl-β-d-glucopyranosylamines.

Georgios Archontis, Loranne Agius, S. Zographos, 2014, Bioorganic & medicinal chemistry.

Crystallographic studies on acyl ureas, a new class of glycogen phosphorylase inhibitors, as potential antidiabetic drugs

T. Klabunde, N. Oikonomakos, D. Leonidas, 2005, Protein science : a publication of the Protein Society.

Crystallographic studies on N-azidoacetyl-beta-D-glucopyranosylamine, an inhibitor of glycogen phosphorylase: comparison with N-acetyl-beta-D-glucopyranosylamine.

Udayanath Aich, N. Oikonomakos, D. Leonidas, 2006, Bioorganic & medicinal chemistry.

Binding of oxalyl derivatives of beta-d-glucopyranosylamine to muscle glycogen phosphorylase b.

N. Oikonomakos, D. Leonidas, E. Chrysina, 2006, Bioorganic & medicinal chemistry.

The binding of D-gluconohydroximo-1,5-lactone to glycogen phosphorylase. Kinetic, ultracentrifugation and crystallographic studies.

N. Oikonomakos, A. Vasella, D. Leonidas, 1991, The Biochemical journal.

Morpholino, piperidino, and pyrrolidino derivatives of pyrimidine nucleosides as inhibitors of ribonuclease A: synthesis, biochemical, and crystallographic evaluation.

S. Zographos, N. Oikonomakos, D. Leonidas, 2009, Journal of medicinal chemistry.

Cleavage of 3',5'-pyrophosphate-linked dinucleotides by ribonuclease A and angiogenin.

R. Raines, J. Jenkins, K. Acharya, 2001, Biochemistry.