Haitao Ji

发表

Hot spot-based design of small-molecule inhibitors for protein-protein interactions.

Wenxing Guo, J. A. Wisniewski, Haitao Ji, 2014, Bioorganic & medicinal chemistry letters.

AlphaScreen selectivity assay for β-catenin/B-cell lymphoma 9 inhibitors.

M. Zhang, J. A. Wisniewski, Haitao Ji, 2015, Analytical biochemistry.

Computer modeling of selective regions in the active site of nitric oxide synthases: implication for the design of isoform-selective inhibitors.

T. Poulos, Haitao Ji, Huiying Li, 2003, Journal of medicinal chemistry.

Minimal pharmacophoric elements and fragment hopping, an approach directed at molecular diversity and isozyme selectivity. Design of selective neuronal nitric oxide synthase inhibitors.

T. Poulos, Haitao Ji, Huiying Li, 2008, Journal of the American Chemical Society.

Discovery of highly potent and selective inhibitors of neuronal nitric oxide synthase by fragment hopping.

T. Poulos, Haitao Ji, Huiying Li, 2009, Journal of medicinal chemistry.

Structure-based optimization of azole antifungal agents by CoMFA, CoMSIA, and molecular docking.

Min Zhang, Hui Xu, Youjun Zhou, 2006, Journal of medicinal chemistry.

Fragment‐Based Drug Design: Considerations for Good ADME Properties

Haitao Ji, 2010 .

Synthesis and Structural Characterization of a Monocarboxylic Inhibitor for GRB2 SH2 Domain.

M. Zhang, Haitao Ji, E. Haura, 2021, Bioorganic & medicinal chemistry letters.

Protocol for fragment hopping.

Haitao Ji, Kevin B. Teuscher, 2015, Methods in molecular biology.

Design, synthesis and antifungal activity of isosteric analogues of benzoheterocyclic N-myristoyltransferase inhibitors.

Shengzheng Wang, Haitao Ji, Yongbing Cao, 2010, European journal of medicinal chemistry.

Optimization of Peptidomimetics as Selective Inhibitors for the β-Catenin/T-Cell Factor Protein-Protein Interaction.

M. Zhang, Haitao Ji, Zhen Wang, 2019, Journal of medicinal chemistry.

Enantiomers of 4-amino-3-fluorobutanoic acid as substrates for gamma-aminobutyric acid aminotransferase. Conformational probes for GABA binding.

Haitao Ji, R. Silverman, D. O'Hagan, 2007, Biochemistry.

Discovery of Selective Small-Molecule Inhibitors for the β-Catenin/T-Cell Factor Protein-Protein Interaction through the Optimization of the Acyl Hydrazone Moiety.

M. Zhang, Haitao Ji, Yongqiang Zhang, 2015, Journal of medicinal chemistry.

Case study 3: Fragment hopping to design highly potent and selective neuronal nitric oxide synthase inhibitors

Haitao Ji, R. Silverman, 2013 .

EGF-induced ERK activation promotes CK2-mediated disassociation of alpha-Catenin from beta-Catenin and transactivation of beta-Catenin.

K. Aldape, Haitao Ji, D. Hawke, 2009, Molecular cell.

AKR1B10 activates diacylglycerol (DAG) second messenger in breast cancer cells

Haitao Ji, Yi Shen, Junfei Jin, 2018, Molecular carcinogenesis.

Erratum to “Hot spot-based design of small-molecule inhibitors for protein–protein interactions” [Bioorg. Med. Chem. Lett. 24 (2014) 2546–2554]

Wenxing Guo, J. A. Wisniewski, Haitao Ji, 2014 .

ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect.

K. Aldape, Xiaomin Chen, L. Cantley, 2012, Nature cell biology.

Crystal structures of constitutive nitric oxide synthases in complex with de novo designed inhibitors.

T. Poulos, Haitao Ji, Huiying Li, 2009, Journal of medicinal chemistry.

Targeting nitric oxide signaling with nNOS inhibitors as a novel strategy for the therapy and prevention of human melanoma.

T. Poulos, Haitao Ji, F. Meyskens, 2013, Antioxidants & redox signaling.

Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

K. Aldape, Haitao Ji, Weiwei Yang, 2011, Nature.

Corrigendum: Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

K. Aldape, Haitao Ji, Weiwei Yang, 2017, Nature.

FAM129B activates Ras and promotes aerobic glycolysis

Haitao Ji, Zhimin Lu, Jong-Ho Lee, 2016, Cell cycle.

Inhibition of p53 DNA binding by a small molecule protects mice from radiation toxicity

Jiandong Chen, G. Daughdrill, Lihong Chen, 2020, Oncogene.

The Role of Protein Kinase CK2 in Glioblastoma Development

Haitao Ji, Zhimin Lu, 2013, Clinical Cancer Research.

Preclinical evaluation of [225Ac]Ac-DOTA-TATE for treatment of lung neuroendocrine neoplasms

R. Engelman, M. Budzevich, D. Boulware, 2021, European Journal of Nuclear Medicine and Molecular Imaging.

Structure-based rational design, synthesis and antifungal activity of oxime-containing azole derivatives.

Shengzheng Wang, Haitao Ji, Yongbing Cao, 2010, Bioorganic & medicinal chemistry letters.

Selective monocationic inhibitors of neuronal nitric oxide synthase. Binding mode insights from molecular dynamics simulations.

T. Poulos, Haitao Ji, Huiying Li, 2012, Journal of the American Chemical Society.

Fragment hopping protocol for the design of small-molecule protein-protein interaction inhibitors.

Haitao Ji, Zhen Wang, Shelby R. Kell, 2022, Bioorganic & medicinal chemistry.

Cyclopropyl- and methyl-containing inhibitors of neuronal nitric oxide synthase.

T. Poulos, Haitao Ji, Huiying Li, 2013, Bioorganic & medicinal chemistry.

Unexpected binding modes of nitric oxide synthase inhibitors effective in the prevention of a cerebral palsy phenotype in an animal model.

T. Poulos, Haitao Ji, Huiying Li, 2010, Journal of the American Chemical Society.

Synthesis and enzymatic evaluation of 2- and 4-aminothiazole-based inhibitors of neuronal nitric oxide synthase

Haitao Ji, P. Martásek, R. Silverman, 2009, Beilstein journal of organic chemistry.

Direct α-heteroarylation of amides (α to nitrogen) and ethers through a benzaldehyde-mediated photoredox reaction

Haitao Ji, Yongqiang Zhang, Kevin B. Teuscher, 2015, Chemical science.

Direct α‐Heteroarylation of Amides (α to Nitrogen) and Ethers Through a Benzaldehyde‐Mediated Photoredox Reaction.

Haitao Ji, Yongqiang Zhang, Kevin B. Teuscher, 2016 .

Structure-Based Optimization of Small-Molecule Inhibitors for the β-Catenin/B-Cell Lymphoma 9 Protein-Protein Interaction.

M. Zhang, Wenxing Guo, Haitao Ji, 2018, Journal of medicinal chemistry.

New ZW4864 Derivatives as Small-Molecule Inhibitors for the β-Catenin/BCL9 Protein-Protein Interaction.

Haitao Ji, Min Zhang, Zhen Wang, 2022, ACS medicinal chemistry letters.

Neuronal Nitric Oxide Synthase Inhibition Prevents Cerebral Palsy following Hypoxia-Ischemia in Fetal Rabbits: Comparison between JI-8 and 7-Nitroindazole

Haitao Ji, Lei Yu, M. Derrick, 2011, Developmental Neuroscience.

Antenatal insults modify newborn olfactory function by nitric oxide produced from neuronal nitric oxide synthase

L. Kay, A. Drobyshevsky, Haitao Ji, 2012, Experimental Neurology.

The Enantiomers of 4-Amino-3-fluorobutanoic Acid as Substrates for γ -Aminobutyric Acid Aminotransferase. Conformational Probes for GABA Binding

Haitao Ji, R. Silverman, D. O'Hagan, 2008 .

Design, Synthesis, and Antifungal Activity of Novel Conformationally Restricted Triazole Derivatives

Haitao Ji, Zhenyuan Miao, Jianzhong Yao, 2009, Archiv der Pharmazie.

New azoles with potent antifungal activity: design, synthesis and molecular docking.

Haitao Ji, Yongbing Cao, Guoqiang Dong, 2009, European journal of medicinal chemistry.

Common Structural Features of Hydrophobic α-Helical Hot Spots: Insights for the Design of Novel α-Helix Mimetics.

Haitao Ji, Zhen Wang, Shelby R. Kell, 2022, ACS medicinal chemistry letters.

New homocamptothecins: synthesis, antitumor activity, and molecular modeling.

M. Zhang, Haitao Ji, Zhenyuan Miao, 2008, Bioorganic & medicinal chemistry.

Discovery of highly potent novel antifungal azoles by structure-based rational design.

Haitao Ji, Yongbing Cao, Zhenyuan Miao, 2009, Bioorganic & medicinal chemistry letters.

Synthesis and antifungal activities of novel 2-aminotetralin derivatives.

Haitao Ji, Jun Chen, Yuan-Ying Jiang, 2007, Journal of medicinal chemistry.

Rhodium-Catalyzed [4 + 1] Cyclization via C-H Activation for the Synthesis of Divergent Heterocycles Bearing a Quaternary Carbon.

Haitao Ji, Xiaowei Wu, 2018, The Journal of organic chemistry.

Ruthenium(II)-Catalyzed Regio- and Stereoselective C-H Allylation of Indoles with Allyl Alcohols.

Haitao Ji, Xiaowei Wu, 2018, Organic letters.

Ruthenium-Catalyzed C-H Allylation of Alkenes with Allyl Alcohols via C-H Bond Activation in Aqueous Solution.

Haitao Ji, Xiaowei Wu, 2018, The Journal of organic chemistry.

Three-Dimensional Model of Lanosterol 14α-Demethylase from Cryptococcus neoformans: Active-Site Characterization and Insights into Azole Binding

Haitao Ji, Wei Guo, Guoqiang Dong, 2009, Antimicrobial Agents and Chemotherapy.

Exploration of the active site of neuronal nitric oxide synthase by the design and synthesis of pyrrolidinomethyl 2-aminopyridine derivatives.

T. Poulos, Haitao Ji, Huiying Li, 2010, Journal of medicinal chemistry.

Improved Model of Lanosterol 14α‐Demethylase by Ligand‐Supported Homology Modeling: Validation by Virtual Screening and Azole Optimization

Shengzheng Wang, Haitao Ji, Guoqiang Dong, 2010, ChemMedChem.

Acid-Facilitated Debenzylation of N-Boc, N-Benzyl Double Protected 2-Aminopyridinomethylpyrrolidine Derivatives.

Haitao Ji, R. Silverman, Jinwen Huang, 2012, Tetrahedron.

Conformationally restricted dipeptide amides as potent and selective neuronal nitric oxide synthase inhibitors.

Haitao Ji, P. Martásek, R. Silverman, 2006, Journal of medicinal chemistry.

Inhibition of β-catenin/B cell lymphoma 9 protein−protein interaction using α-helix–mimicking sulfono-γ-AApeptide inhibitors

M. Zhang, Haitao Ji, Peng Sang, 2019, Proceedings of the National Academy of Sciences.

Homology Modeling of Lanosterol 14α-Demethylase of Candida albicans and Aspergillus fumigatus and Insights into the Enzyme-Substrate Interactions

Haitao Ji, Yunlong Song, Jianzhong Yao, 2004, Journal of biomolecular structure & dynamics.

Remote protection prevents unwanted cyclizations with 2-aminopyridines

Haitao Ji, R. Silverman, Graham R. Lawton, 2006 .

Rhodium(iii)-catalyzed C-H allylation of indoles with allyl alcohols via β-hydroxide elimination.

Haitao Ji, Xiaowei Wu, 2018, Organic & biomolecular chemistry.

α-Catenin inhibits glioma cell migration, invasion, and proliferation by suppression of β-catenin transactivation

Haitao Ji, B. Fang, Zhimin Lu, 2011, Journal of Neuro-Oncology.

ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect

K. Aldape, Xiaomin Chen, L. Cantley, 2012, Nature Cell Biology.

Direct targeting of β‐catenin in the Wnt signaling pathway: Current progress and perspectives

Haitao Ji, Zilu Li, Zhen Wang, 2021, Medicinal research reviews.

Discovery of 2-(3-(3-Carbamoylpiperidin-1-yl)phenoxy)acetic Acid Derivatives as Novel Small-Molecule Inhibitors of the β-Catenin/B-Cell Lymphoma 9 Protein-Protein Interaction.

M. Zhang, Haitao Ji, Yongqiang Zhang, 2021, Journal of medicinal chemistry.

AKT‐dependent phosphorylation of Niban regulates nucleophosmin‐ and MDM2‐mediated p53 stability and cell apoptosis

Bing-Hua Jiang, Gordon B Mills, David Hawke, 2012, EMBO reports.

Differential Regulation of c-Jun Protein Plays an Instrumental Role in Chemoresistance of Cancer Cells*

Haitao Ji, Weiwei Yang, Zhimin Lu, 2013, The Journal of Biological Chemistry.

Discovery of an Orally Bioavailable Small-Molecule Inhibitor for the β-Catenin/B-Cell Lymphoma 9 Protein-Protein Interaction.

M. Zhang, Haitao Ji, V. Quereda, 2021, Journal of medicinal chemistry.

New homogeneous high-throughput assays for inhibitors of β-catenin/Tcf protein-protein interactions.

M. Zhang, Haitao Ji, Binxun Yu, 2012, Analytical biochemistry.

Discovery of 1-Benzoyl 4-Phenoxypiperidines as Small-Molecule Inhibitors of the β-Catenin/B-Cell Lymphoma 9 Protein-Protein Interaction.

M. Zhang, Haitao Ji, Zilu Li, 2021, Journal of medicinal chemistry.

A Versatile Method to Determine the Cellular Bioavailability of Small-Molecule Inhibitors

Haitao Ji, Kevin B. Teuscher, Min Zhang, 2017, Journal of medicinal chemistry.

Rational design of selective small-molecule inhibitors for β-catenin/B-cell lymphoma 9 protein-protein interactions.

Min Zhang, Haitao Ji, J. A. Wisniewski, 2015, Journal of the American Chemical Society.

EGFR phosphorylates FAM129B to promote Ras activation

Tao Zhang, Haitao Ji, Zhimin Lu, 2015, Proceedings of the National Academy of Sciences.

Characterization of Hydrophilic α-Helical Hot Spots on the Protein-Protein Interaction Interfaces for the Design of α-Helix Mimetics

Haitao Ji, Zhen Wang, 2022, J. Chem. Inf. Model..

Targeting the Side-Chain Convergence of Hydrophobic α-Helical Hot Spots to Design Small-Molecule Mimetics: Key Binding Features for i, i + 3 and i + 7.

Haitao Ji, Zhen Wang, 2019, Journal of medicinal chemistry.

Structure-based design, synthesis, and biological evaluation of lipophilic-tailed monocationic inhibitors of neuronal nitric oxide synthase.

T. Poulos, Haitao Ji, Huiying Li, 2010, Bioorganic & medicinal chemistry.

Hypoxia–ischemia causes persistent movement deficits in a perinatal rabbit model of cerebral palsy: assessed by a new swim test

A. Drobyshevsky, Haitao Ji, M. Derrick, 2009, International Journal of Developmental Neuroscience.

Homology modeling and molecular dynamics simulation of N-myristoyltransferase from protozoan parasites: active site characterization and insights into rational inhibitor design

Wei Guo, Wenya Wang, Guoqiang Dong, 2009, J. Comput. Aided Mol. Des..

ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect

K. Aldape, Xiaomin Chen, L. Cantley, 2012, Nature Cell Biology.

Analogues of 2-aminopyridine-based selective inhibitors of neuronal nitric oxide synthase with increased bioavailability.

Haitao Ji, P. Martásek, R. Silverman, 2009, Bioorganic & medicinal chemistry.

Intramolecular hydrogen bonding: a potential strategy for more bioavailable inhibitors of neuronal nitric oxide synthase.

T. Poulos, Haitao Ji, Huiying Li, 2012, Bioorganic & medicinal chemistry.

Improved synthesis of chiral pyrrolidine inhibitors and their binding properties to neuronal nitric oxide synthase.

T. Poulos, Haitao Ji, Huiying Li, 2011, Journal of medicinal chemistry.

L337H mutant of rat neuronal nitric oxide synthase resembles human neuronal nitric oxide synthase toward inhibitors.

Haitao Ji, R. Silverman, L. Roman, 2009, Journal of medicinal chemistry.

Selective neuronal nitric oxide synthase inhibitors.

Haitao Ji, Jiwon Seo, R. Silverman, 2005, Current topics in medicinal chemistry.

Selective neuronal nitric oxide synthase inhibitors and the prevention of cerebral palsy

T. Poulos, Haitao Ji, Huiying Li, 2009, Annals of neurology.

Involvement of Neuronal Nitric Oxide Synthase in Ongoing Fetal Brain Injury following Near-Term Rabbit Hypoxia-Ischemia

A. Drobyshevsky, Haitao Ji, Zhenlang Lin, 2011, Developmental Neuroscience.

Structure-Based Design of 1,4-Dibenzoylpiperazines as β-Catenin/B-Cell Lymphoma 9 Protein-Protein Interaction Inhibitors.

M. Zhang, J. A. Wisniewski, Haitao Ji, 2016, ACS medicinal chemistry letters.

Targeting the Tcf4 G13ANDE17 binding site to selectively disrupt β-catenin/T-cell factor protein-protein interactions.

S. Burton, Haitao Ji, Zhengui Huang, 2014, ACS chemical biology.

High-Throughput Selectivity Assays for Small-Molecule Inhibitors of β-Catenin/T-Cell Factor Protein-Protein Interactions.

M. Zhang, Haitao Ji, J. L. Catrow, 2013, ACS medicinal chemistry letters.

Theoretical study on potency and selectivity of novel non-peptide inhibitors of matrix metalloproteinases MMP-1 and MMP-3

Qingchuan Zheng, Hong-Xing Zhang, Haitao Ji, 2008 .

Partial neuroprotection by nNOS inhibition during profound asphyxia in preterm fetal sheep

A. Gunn, L. Bennet, Haitao Ji, 2013, Experimental Neurology.

nNOS inhibition during profound asphyxia reduces seizure burden and improves survival of striatal phenotypic neurons in preterm fetal sheep

A. Gunn, L. Bennet, Haitao Ji, 2014, Neuropharmacology.

Rational design of small-molecule inhibitors for β-catenin/T-cell factor protein-protein interactions by bioisostere replacement.

Haitao Ji, Binxun Yu, Zhengui Huang, 2013, ACS chemical biology.

The Mobility of a Conserved Tyrosine Residue Controls Isoform-Dependent Enzyme–Inhibitor Interactions in Nitric Oxide Synthases

T. Poulos, Haitao Ji, Huiying Li, 2014, Biochemistry.

AKT‐dependent phosphorylation of Niban regulates nucleophosmin‐ and MDM2‐mediated p53 stability and cell apoptosis

G. Mills, Z. Ding, B. Jiang, 2014 .

Evolutionary trace analysis of CYP51 family: implication for site-directed mutagenesis and novel antifungal drug design

Shuanghong Chen, Haitao Ji, Wei Guo, 2010, Journal of molecular modeling.

EGF-induced ERK activation promotes CK2-mediated disassociation of alpha-Catenin from beta-Catenin and transactivation of beta-Catenin.

K. Aldape, Haitao Ji, D. Hawke, 2009, Molecular cell.

Selective neuronal nitric oxide synthase inhibitors and the prevention of cerebral palsy

T. Poulos, Haitao Ji, Huiying Li, 2009, Annals of neurology.

New azoles with potent antifungal activity: design, synthesis and molecular docking.

Haitao Ji, Yongbing Cao, Guoqiang Dong, 2009, European journal of medicinal chemistry.

Hypoxia–ischemia causes persistent movement deficits in a perinatal rabbit model of cerebral palsy: assessed by a new swim test

A. Drobyshevsky, Haitao Ji, M. Derrick, 2009, International Journal of Developmental Neuroscience.

Selective neuronal nitric oxide synthase inhibitors.

Haitao Ji, Jiwon Seo, R. Silverman, 2005, Current topics in medicinal chemistry.

Structure-Based Design of 1,4-Dibenzoylpiperazines as β-Catenin/B-Cell Lymphoma 9 Protein-Protein Interaction Inhibitors.

M. Zhang, J. A. Wisniewski, Haitao Ji, 2016, ACS medicinal chemistry letters.

AlphaScreen selectivity assay for β-catenin/B-cell lymphoma 9 inhibitors.

M. Zhang, J. A. Wisniewski, Haitao Ji, 2015, Analytical biochemistry.

AKT‐dependent phosphorylation of Niban regulates nucleophosmin‐ and MDM2‐mediated p53 stability and cell apoptosis

G. Mills, Z. Ding, B. Jiang, 2012, EMBO reports.