B. Aquila

发表

Discovery and optimization of covalent Bcl-xL antagonists.

H. Mukherjee, Nancy Su, Matthew A. Belmonte, 2019, Bioorganic & medicinal chemistry letters.

Inhibition of Mcl-1 through covalent modification of a noncatalytic lysine side chain.

C. Chuaqui, Nancy Su, Matthew A. Belmonte, 2016, Nature chemical biology.

Effects of Molecular Oxygen, Solvent, and Light on Iridium-Photoredox/Nickel Dual-Catalyzed Cross-Coupling Reactions.

B. Aquila, A. Varela-Álvarez, Daniel W. Robbins, 2015, The Journal of organic chemistry.

Photoredox Mediated Nickel Catalyzed Cross-Coupling of Thiols With Aryl and Heteroaryl Iodides via Thiyl Radicals.

B. Aquila, M. Frenette, Daniel W. Robbins, 2016, Journal of the American Chemical Society.

Identification of amidoheteroaryls as potent inhibitors of mutant (V600E) B-Raf kinase with in vivo activity.

David A. Scott, P. Lyne, L. Drew, 2009, Bioorganic & medicinal chemistry letters.

Highly Chemoselective Iridium Photoredox and Nickel Catalysis for the Cross-Coupling of Primary Aryl Amines with Aryl Halides.

S. Tentarelli, B. Aquila, M. Frenette, 2016, Angewandte Chemie.

β-Functionalization of Saturated Aza-Heterocycles Enabled by Organic Photoredox Catalysis.

David A. Nicewicz, B. Aquila, D. Nicewicz, 2021, ACS catalysis.

Small molecule inhibitor of apoptosis proteins antagonists: a patent review

E. Hennessy, B. Aquila, A. Hird, 2015, Expert opinion on therapeutic patents.

Discovery of aminopiperidine-based Smac mimetics as IAP antagonists.

E. Hennessy, A. Ferguson, B. Aquila, 2012, Bioorganic & medicinal chemistry letters.

Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia

J. A. Hendricks, David M. Wilson, S. Kazmirski, 2018, Nature Communications.

Pyridyl and thiazolyl bisamide CSF-1R inhibitors for the treatment of cancer.

David A. Scott, P. Lyne, B. Aquila, 2008, Bioorganic & medicinal chemistry letters.

Kinase Inhibitors in Cancer

B. Aquila, A. Mortlock, J. Kettle, 2013 .

A new synthesis of 8-methylpsoralen utilizing a palladium-copper catalyzed reaction to generate the furan ring and thus allowing for the generation of novel analogs in the 5′-position

B. Aquila, 1997 .

Positional Analogue Scanning: An Effective Strategy for Multiparameter Optimization in Drug Design.

I. Muegge, B. Aquila, L. Pennington, 2020, Journal of medicinal chemistry.

A study of the reactivity of S(VI)-F containing warheads with nucleophilic amino-acid side chains under physiological conditions.

A. Whitty, J. Breed, J. Debreczeni, 2017, Organic & biomolecular chemistry.

Photoredox Mediated Nickel Catalyzed Cross‐Coupling of Thiols with Aryl and Heteroaryl Iodides via Thiyl Radicals.

B. Aquila, M. Frenette, Daniel W. Robbins, 2016 .

Structure-based design and synthesis of tricyclic IAP (Inhibitors of Apoptosis Proteins) inhibitors.

E. Hennessy, B. Aquila, A. Hird, 2014, Bioorganic & medicinal chemistry letters.

Discovery of a novel class of dimeric Smac mimetics as potent IAP antagonists resulting in a clinical candidate for the treatment of cancer (AZD5582).

E. Hennessy, V. Oza, B. Aquila, 2013, Journal of medicinal chemistry.

Linking molecular characteristics to the pharmacological response of a panel of cancer cell lines to the BRAF inhibitor, AZ628

P. Lyne, L. Drew, B. Aquila, 2007 .

A study of the reactivity of S(VI)-F containing warheads with nucleophilic amino-acid side chains under physiological conditions.

A. Whitty, J. Breed, J. Debreczeni, 2017, Organic & biomolecular chemistry.

Synthesis and evaluation of a novel bleomycin A2 analogue: continuing assessment of the linker domain

D. Boger, W. Tse, B. Aquila, 2000 .