S. Sagan

发表

Structure and Dynamics of an Intrinsically Disordered Protein Region That Partially Folds upon Binding by Chemical-Exchange NMR.

P. Pelupessy, G. Bouvignies, A. Aggarwal, 2017, Journal of the American Chemical Society.

Cell‐penetrating peptides: 20 years later, where do we stand?

S. Sagan, Cherine Bechara, Sandrine Sagan, 2013, FEBS letters.

Membrane Crossover by Cell-Penetrating Peptides: Kinetics and Mechanisms – From Model to Cell Membrane Perturbation by Permeant Peptides

I. Alves, S. Sagan, S. Cribier, 2011 .

Binding and crossing: Methods for the characterization of membrane-active peptides interactions with membranes at the molecular level.

A. Walrant, S. Sagan, S. Cribier, 2021, Archives of biochemistry and biophysics.

Membrane Crossing and Membranotropic Activity of Cell-Penetrating Peptides: Dangerous Liaisons?

A. Walrant, S. Sagan, S. Cardon, 2017, Accounts of chemical research.

Translocation and Endocytosis for Cell-penetrating Peptide Internalization

Isabel D. Alves, I. Alves, S. Sagan, 2009, The Journal of Biological Chemistry.

The interaction of cell‐penetrating peptides with lipid model systems and subsequent lipid reorganization: thermodynamic and structural characterization

I. Alves, G. Tollin, S. Sagan, 2009, Journal of peptide science : an official publication of the European Peptide Society.

Relationships between Membrane Binding, Affinity and Cell Internalization Efficacy of a Cell-Penetrating Peptide: Penetratin as a Case Study

I. Alves, A. Walrant, S. Sagan, 2011, PloS one.

Molecular partners for interaction and cell internalization of cell-penetrating peptides: how identical are they?

I. Alves, A. Walrant, S. Sagan, 2012, Nanomedicine.

Tracking a new cell-penetrating (W/R) nonapeptide, through an enzyme-stable mass spectrometry reporter tag.

S. Sagan, S. Lavielle, G. Bolbach, 2007, Analytical chemistry.

Homeoproteins and homeoprotein-derived peptides: going in and out.

I. Alves, E. Dupont, A. Joliot, 2013, Current pharmaceutical design.

Massive glycosaminoglycan-dependent entry of Trp-containing cell-penetrating peptides induced by exogenous sphingomyelinase or cholesterol depletion

S. Sagan, S. Cribier, Cherine Bechara, 2015, Cellular and Molecular Life Sciences.

Head to tail cyclisation of cell-penetrating peptides: impact on GAG-dependent internalisation and direct translocation.

A. Joliot, S. Sagan, M. Amoura, 2019, Chemical communications.

Membrane interaction and perturbation mechanisms induced by two cationic cell penetrating peptides with distinct charge distribution.

I. Alves, S. Sagan, N. Goasdoué, 2008, Biochimica et biophysica acta.

Influence of the Dabcyl group on the cellular uptake of cationic peptides: short oligoarginines as efficient cell-penetrating peptides

S. Futaki, S. Sagan, S. Bősze, 2021, Amino Acids.

Modification of Short Non‐Permeable Peptides to Increase Cellular Uptake and Cytostatic Activity of Their Conjugates

S. Sagan, Z. Bánóczi, B. Szeder, 2021, ChemistrySelect.

A cationic motif in Engrailed-2 homeoprotein controls its internalization via selective cell-surface glycosaminoglycans interactions

A. Joliot, A. Walrant, S. Sagan, 2021, bioRxiv.

Penetratin translocation mechanism through asymmetric droplet interface bilayers.

P. Soule, A. Walrant, S. Sagan, 2020, Biochimica et biophysica acta. Biomembranes.

Specific interaction of Penetratin with cell surface partners measured with biomembrane force probe

P. Soule, A. Joliot, S. Sagan, 2020, bioRxiv.

Exploiting Benzophenone Photoreactivity To Probe the Phospholipid Environment and Insertion Depth of the Cell-Penetrating Peptide Penetratin in Model Membranes.

I. Alves, S. Sagan, G. Bolbach, 2017, Angewandte Chemie.

Amphiphilic Macromolecules on Cell Membranes: From Protective Layers to Controlled Permeabilization

C. Tribet, S. Sagan, S. Cribier, 2014, The Journal of Membrane Biology.

Different membrane behaviour and cellular uptake of three basic arginine-rich peptides.

I. Alves, A. Walrant, S. Sagan, 2011, Biochimica et biophysica acta.

Comparing lipid photo-cross-linking efficacy of penetratin analogues bearing three different photoprobes: dithienyl ketone, benzophenone, and trifluoromethylaryldiazirine.

I. Alves, S. Sagan, S. Lavielle, 2010, Bioconjugate chemistry.

Lipid reorganization induced by membrane-active peptides probed using differential scanning calorimetry.

I. Alves, S. Sagan, N. Goasdoué, 2009, Biochimica et biophysica acta.

HIV gp41 Engages gC1qR on CD4+ T Cells to Induce the Expression of an NK Ligand through the PIP3/H2O2 Pathway

P. Debré, H. Fausther-Bovendo, S. Sagan, 2010, PLoS pathogens.

Antimicrobial activity of lysozyme isoforms: Key molecular features

V. Vié, A. Walrant, S. Sagan, 2017, Biopolymers.

V(H)H (nanobody) directed against human glycophorin A: a tool for autologous red cell agglutination assays.

S. Muyldermans, S. Sagan, O. Bertrand, 2013, Analytical biochemistry.

CγH2 of Met174 Side Chain Is the Site of Covalent Attachment of a Substance P Analog Photoactivable in Position 5*

S. Sagan, S. Lavielle, G. Bolbach, 2002, The Journal of Biological Chemistry.

An integrated cross-linking-MS approach to investigate cell penetrating peptides interacting partners

S. Sagan, G. Bolbach, Xiuxia Du, 2014 .

Quantitative fluorescence spectroscopy and flow cytometry analyses of cell-penetrating peptides internalization pathways: optimization, pitfalls, comparison with mass spectrometry quantification

A. Joliot, S. Sagan, S. Cribier, 2016, Scientific Reports.

Cell‐surface thiols affect cell entry of disulfide‐conjugated peptides

E. Dupont, A. Joliot, S. Sagan, 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

1,1-Diphenyl-2-methylsulfinyl ethanol: a model compound to study the reactivity towards CNBr of a photoadduct of methionine on CγH2

S. Sagan, S. Lavielle, G. Chassaing, 2002 .

Photocontrol of the translocation of molecules, peptides, and quantum dots through cell and lipid membranes doped with azobenzene copolymers.

I. Alves, C. Tribet, A. Walrant, 2012, Angewandte Chemie.

Sequence-dependent enrichment of a model phosphopeptide: a combined MALDI-TOF and NMR study.

S. Sagan, O. Lequin, L. Mathéron, 2011, Analytical chemistry.

Characterization of the receptor binding profile of (3H)-dermorphin in the rat brain.

S. Sagan, A. Mor, P. Nicolas, 2009, International journal of peptide and protein research.

An artificial amphiphilic peptide promotes endocytic uptake by inducing membrane curvature.

S. Futaki, A. Walrant, S. Sagan, 2020, Bioconjugate chemistry.

Proteomic comparison of the EWS-FLI1 expressing cells EF with NIH-3T3 and actin remodeling effect of (R/W)9 cell-penetrating peptide

S. Sagan, G. Bolbach, E. Sachon, 2015, EuPA open proteomics.

Pachymodulin, a new functional formyl peptide receptor 2 peptidic ligand isolated from frog skin has Janus-like immunomodulatory capacities.

S. Sagan, Constance Auvynet, C. Piesse, 2015, Journal of medicinal chemistry.

Tryptophan within basic peptide sequences triggers glycosaminoglycan‐dependent endocytosis

I. Alves, S. Sagan, O. Lequin, 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Challenges and Methods for the Study of CPP Translocation Mechanisms.

A. Walrant, S. Sagan, N. Rodriguez, 2021, Methods in molecular biology.

Structural Bases for the Involvement of Phosphatidylinositol-4,5-bisphosphate in the Internalization of the Cell-Penetrating Peptide Penetratin.

A. Walrant, S. Sagan, L. Carlier, 2022, ACS chemical biology.

Self-assembling mini cell-penetrating peptides enter by both direct translocation and glycosaminoglycan-dependent endocytosis.

S. Sagan, S. Lavielle, G. Chassaing, 2012, Chemical communications.

Modifications in the chemical structure of Trojan carriers: impact on cargo delivery.

E. Dupont, A. Joliot, S. Sagan, 2008, Chemical communications.

Tryptophan, more than just an interfacial amino acid in the membrane activity of cationic cell-penetrating and antimicrobial peptides

A. Walrant, S. Sagan, Sonia Khemaissa, 2022, Quarterly Reviews of Biophysics.

A direct approach to quantification of the cellular uptake of cell-penetrating peptides using MALDI-TOF mass spectrometry

S. Sagan, G. Bolbach, G. Chassaing, 2006, Nature Protocols.

Cellular uptake and biophysical properties of galactose and/or tryptophan containing cell-penetrating peptides.

I. Alves, A. Walrant, S. Sagan, 2012, Biochimica et biophysica acta.

Tachykinin NK-1 receptor probed with constrained analogues of substance P.

S. Sagan, P. Karoyan, S. Lavielle, 1996, Bioorganic & medicinal chemistry.

Mechanism of δ-opioid receptor selection by the address domain of dermenkephalin

S. Sagan, P. Nicolas, A. Delfour, 1994 .

Anandamide and WIN 55212‐2 inhibit cyclic AMP formation through G‐protein‐coupled receptors distinct from CB1 cannabinoid receptors in cultured astrocytes

J. Glowinski, L. Venance, C. Giaume, 1999, The European journal of neuroscience.

Quantification of the cellular uptake of cell-penetrating peptides by MALDI-TOF mass spectrometry.

S. Sagan, G. Bolbach, G. Chassaing, 2005, Angewandte Chemie.

Tachykinin peptides affect differently the second messenger pathways after binding to CHO-expressed human NK-1 receptors.

S. Sagan, S. Lavielle, G. Chassaing, 1996, The Journal of pharmacology and experimental therapeutics.

Biological activity of silylated amino acid containing substance P analogues.

S. Sagan, D. Marchand, F. Cavelier, 2004, The journal of peptide research : official journal of the American Peptide Society.

Asymmetric synthesis of Boc-N-methyl-p-benzoyl-phenylalanine. Preparation of a photoreactive antagonist of substance P.

S. Sagan, P. Karoyan, S. Lavielle, 1998, Bioorganic & medicinal chemistry letters.

Small AntiMicrobial Peptide with In Vivo Activity Against Sepsis

S. Sagan, P. Karoyan, P. Launay, 2019, Molecules.

N- and Cα-Methylation in Biologically Active Peptides: Synthesis, Structural and Functional Aspects

S. Sagan, O. Lequin, P. Karoyan, 2004 .

Structural and biological effects of a β2‐ or β3‐amino acid insertion in a peptide

S. Sagan, O. Lequin, S. Lavielle, 2003 .

Tryptophan, an Amino-Acid Endowed with Unique Properties and Its Many Roles in Membrane Proteins

A. Walrant, S. Sagan, Sonia Khemaissa, 2021, Crystals.

Ionpair-π interactions favor cell penetration of arginine/tryptophan-rich cell-penetrating peptides.

I. Alves, A. Walrant, S. Sagan, 2020, Biochimica et biophysica acta. Biomembranes.

Ionpair-π interactions favor cell penetration of arginine/tryptophan-rich cell-penetrating peptides

I. Alves, A. Walrant, S. Sagan, 2019, bioRxiv.

Benzophenone Photoreactivity in a Lipid Bilayer To Probe Peptide/Membrane Interactions: Simple System, Complex Information.

A. Walrant, S. Sagan, L. Mathéron, 2019, Analytical chemistry.

A proapoptotic peptide conjugated to penetratin selectively inhibits tumor cell growth.

I. Alves, R. Marquant, S. Sagan, 2014, Biochimica et biophysica acta.

Membrane interactions of two arginine-rich peptides with different cell internalization capacities.

I. Alves, A. Walrant, S. Sagan, 2012, Biochimica et biophysica acta.

Glycosylated cell-penetrating peptides and their conjugates to a proapoptotic peptide: preparation by click chemistry and cell viability studies

R. Marquant, S. Sagan, S. Lavielle, 2010, Journal of chemical biology.

Analogs of Substance P modified at the C-terminus which are both agonist and antagonist of the NK-1 receptor depending on the second messenger pathway.

S. Sagan, S. Lavielle, G. Chassaing, 2002, The journal of peptide research : official journal of the American Peptide Society.

Incorporation of vinylogous scaffolds in the C-terminal tripeptide of substance P.

S. Sagan, S. Lavielle, C. Grison, 2004, The journal of peptide research : official journal of the American Peptide Society.

Topographic analysis of the S7 binding subsite of the tachykinin neurokinin-1 receptor.

S. Sagan, S. Lavielle, G. Chassaing, 1998, Biopolymers.

The human sperm protein PH‐20 has hyaluronidase activity

S. Sagan, G. Kreil, M. Gmachl, 1993, FEBS letters.

Enfuvirtide-Protoporphyrin IX Dual-Loaded Liposomes: In Vitro Evidence of Synergy against HIV-1 Entry into Cells.

Marco M. Domingues, A. Walrant, S. Sagan, 2019, ACS infectious diseases.

A direct label-free MALDI-TOF mass spectrometry based assay for the characterization of inhibitors of protein lysine methyltransferases

S. Sagan, G. Bolbach, C. Guillou, 2017, Analytical and Bioanalytical Chemistry.

MALDI-TOF mass spectrometry analysis of amphipol-trapped membrane proteins.

J. Popot, F. Zito, G. Durand, 2012, Analytical chemistry.

Isotope and affinity tags in photoreactive substance P analogues to identify the covalent linkage within the NK-1 receptor by MALDI-TOF analysis.

S. Sagan, S. Lavielle, G. Bolbach, 2003, Analytical Chemistry.

MALDI-TOF mass spectrometry: a powerful tool to study the internalization of cell-penetrating peptides.

S. Sagan, S. Lavielle, G. Bolbach, 2010, Biochimica et biophysica acta.

Further Delineation of the Two Binding Sites (R*n) Associated with Tachykinin Neurokinin-1 Receptors Using [3-Prolinomethionine11]SP Analogues*

S. Sagan, P. Karoyan, S. Lavielle, 1999, The Journal of Biological Chemistry.

The role of tryptophans on the cellular uptake and membrane interaction of arginine-rich cell penetrating peptides.

I. Alves, S. Sagan, S. Lecomte, 2015, Biochimica et biophysica acta.

Conformational analysis of the C-terminal Gly-Leu-Met-NH2 tripeptide of substance P bound to the NK-1 receptor.

S. Sagan, O. Lequin, P. Karoyan, 2005, Chemistry & biology.

A cationic motif upstream Engrailed2 homeodomain controls cell internalization through selective interaction with heparan sulfates

A. Joliot, A. Walrant, S. Sagan, 2023, Nature Communications.

The use of photolabelled peptides to localize the substance-P-binding site in the human neurokinin-1 tachykinin receptor.

S. Sagan, S. Lavielle, G. Bolbach, 1996, European journal of biochemistry.

ECL1i, d(LGTFLKC), a novel, small peptide that specifically inhibits CCL2‐dependent migration

S. Sagan, L. Carlier, Constance Auvynet, 2016, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

ERα17p, a peptide reproducing the hinge region of the estrogen receptor α associates to biological membranes: A biophysical approach

M. Kampa, E. Castanas, G. Leclercq, 2012, Steroids.

Cell biology meets biophysics to unveil the different mechanisms of penetratin internalization in cells.

I. Alves, S. Sagan, G. Chassaing, 2010, Biochimica et biophysica acta.

The two NK-1 binding sites are distinguished by one radiolabelled substance P analogue.

S. Sagan, S. Lavielle, Hyun Ryoung Kim, 2003, Biochemical and biophysical research communications.

High affinity binding of [3H]propionyl-[Met(O2)11]substance P(7-11), a tritiated septide-like peptide, in Chinese hamster ovary cells expressing human neurokinin-1 receptors and in rat submandibular glands.

J. Glowinski, S. Sagan, S. Lavielle, 1997, Molecular pharmacology.

P(7–11), a Tritiated Septide-Like Peptide, in Chinese Hamster Ovary Cells Expressing Human Neurokinin-1 Receptors and in Rat Submandibular Glands

J. Glowinski, S. Sagan, S. Lavielle, 1997 .

Cell-Penetrating Dabcyl-Containing Tetraarginines with Backbone Aromatics as Uptake Enhancers

S. Sagan, Z. Bánóczi, F. Illien, 2022, Pharmaceutics.

Peptide‐Grafted Nanodiamonds: Preparation, Cytotoxicity and Uptake in Cells

J. Boudou, S. Sagan, S. Lavielle, 2008, Chembiochem : a European journal of chemical biology.

Amphiphilic Macromolecules on Cell Membranes: From Protective Layers to Controlled Permeabilization

C. Tribet, S. Sagan, S. Cribier, 2014, The Journal of Membrane Biology.

Characterization of the bioactive conformation of the C-terminal tripeptide Gly-Leu-Met-NH2 of substance P using [3-prolinoleucine10]SP analogues.

S. Sagan, O. Lequin, P. Karoyan, 2003, European journal of biochemistry.

Isolation of dermenkephalin from amphibian skin, a high‐affinity (δ‐selective opioid heptapeptide containing a D‐amino acid residue

J. Rossier, S. Sagan, A. Mor, 1989, FEBS letters.

(R)-methanandamide inhibits receptor-induced calcium responses by depleting internal calcium stores in cultured astrocytes

L. Venance, C. Giaume, S. Sagan, 1997, Pflügers Archiv.

Label-free measurement of histone lysine methyltransferases activity by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.

A. Jeltsch, S. Sagan, G. Bolbach, 2014, Analytical biochemistry.

Interaction of the Anti-Proliferative GPER Inverse Agonist ERα17p with the Breast Cancer Cell Plasma Membrane: From Biophysics to Biology

I. Alves, S. Sagan, Y. Jacquot, 2020, Cells.

Involvement of the Second Extracellular Loop (E2) of the Neurokinin-1 Receptor in the Binding of Substance P

S. Sagan, O. Lequin, S. Lavielle, 2002, The Journal of Biological Chemistry.

Pharmacological characterization of tachykinin septide-sensitive binding sites in the rat submaxillary gland

J. Glowinski, S. Sagan, M. Saffroy, 1999, Peptides.

The aspartic acid in deltorphin I and dermenkephalin promotes targeting to delta-opioid receptor independently of receptor binding.

S. Sagan, P. Nicolas, M. Amiche, 1992, Biochemical and biophysical research communications.

Dermenkephalin and deltorphin I reveal similarities within ligand-binding domains of μ- and δ-opioid receptors and an additional address subsite on the δ-receptor

S. Sagan, P. Nicolas, A. Delfour, 1991 .

Opioid activity of dermenkephalin analogues in the guinea‐pig myenteric plexus and the hamster vas deferens

S. Sagan, P. Nicolas, M. Amiche, 1991, British journal of pharmacology.

Characterisation and visualisation of [3H]dermorphin binding to μ opioid receptors in the rat brain

S. Sagan, W. Rostène, A. Mor, 1990 .

Molecular determinants of receptor affinity and selectivity of the natural delta-opioid agonist, dermenkephalin.

S. Sagan, A. Mor, P. Nicolas, 1989, The Journal of biological chemistry.

Differential contribution of C-terminal regions of dermorphin and dermenkephalin to opioid-sites selection and binding potency.

S. Sagan, A. Mor, P. Nicolas, 1989, Biochemical and biophysical research communications.

Dermenkephalin (Tyr-D-Met-Phe-His-Leu-Met-Asp-NH2): a potent and fully specific agonist for the delta opioid receptor.

S. Sagan, A. Mor, P. Nicolas, 1989, Molecular pharmacology.

Opioid peptides from amphibian skin: contribution of the amino acids of the "address" domain to the -selectivity of dermenkephalin

S. Sagan, P. Nicolas, A. Delfour, 1992 .

Dermorphin and related peptides in rat tissues

S. Sagan, A. Mor, P. Nicolas, 1989, Neuropeptides.

Dermenkephalin and deltorphin I reveal similarities within ligand-binding domains of mu- and delta-opioid receptors and an additional address subsite on the delta-receptor.

S. Sagan, P. Nicolas, A. Delfour, 1991, Biochemical and biophysical research communications.

Is there anybody in there? On the mechanisms of wall crossing of cell penetrating peptides.

I. Alves, A. Walrant, S. Sagan, 2012, Current protein and peptide science.

Conjugation of oligo-His peptides to magnetic γ-Fe2O3@SiO2 core-shell nanoparticles promotes their access to the cytosol

C. Ménager, S. Sagan, E. Secret, 2021 .

Graftable SCoMPIs enable the labeling and X-ray fluorescence imaging of proteins† †Electronic supplementary information (ESI) available: Additional studies, experimental procedures, and compounds characterization. See DOI: 10.1039/c8sc00886h

I. Hamachi, S. Sagan, O. Lequin, 2018, Chemical science.

Internalization of [3H]substance P analogues in NK-1 receptor transfected CHO cells.

S. Sagan, S. Lavielle, 2001, Biochemical and Biophysical Research Communications - BBRC.

Quantification of the efficiency of cargo delivery by peptidic and pseudo-peptidic Trojan carriers using MALDI-TOF mass spectrometry.

S. Sagan, G. Bolbach, G. Chassaing, 2006, Biochimica et biophysica acta.

The two NK-1 binding sites correspond to distinct, independent, and non-interconvertible receptor conformational states as confirmed by plasmon-waveguide resonance spectroscopy.

I. Alves, Z. Salamon, G. Tollin, 2006, Biochemistry.

Cα methylation in molecular recognition

S. Sagan, O. Lequin, S. Lavielle, 2001 .

Calpha methylation in molecular recognition. Application to substance P and the two neurokinin-1 receptor binding sites.

S. Sagan, O. Lequin, S. Lavielle, 2001, European journal of biochemistry.

Direct translocation of cell-penetrating peptides in liposomes: a combined mass spectrometry quantification and fluorescence detection study.

I. Alves, A. Walrant, S. Sagan, 2013, Analytical biochemistry.

Met174 side chain is the site of photoinsertion of a substance P competitive peptide antagonist photoreactive in position 8

S. Sagan, P. Karoyan, S. Lavielle, 2003, FEBS letters.