P. Ung

发表

Identifying binding hot spots on protein surfaces by mixed‐solvent molecular dynamics: HIV‐1 protease as a test case

Katrina W. Lexa, H. Carlson, Phani Ghanakota, 2016, Biopolymers.

Redefining the Protein Kinase Conformational Space with Machine Learning.

A. Schlessinger, P. Ung, R. Rahman, 2018, Cell chemical biology.

Inhibitor Discovery for the Human GLUT1 from Homology Modeling and Virtual Screening.

A. Schlessinger, Hailin Hu, Ligong Chen, 2016, ACS chemical biology.

Functional and structural analysis of rare SLC2A2 variants associated with Fanconi‐Bickel syndrome and metabolic traits

A. Schlessinger, K. Giacomini, S. Yee, 2019, Human mutation.

2 Systems Pharmacology : A Network-Based View of Drug Action

R. Iyengar, A. Schlessinger, M. Birtwistle, 2016 .

A Whole Animal Platform to Advance A Clinical Kinase Inhibitor Into New Disease Space

Avner Schlessinger, Masahiro Sonoshita, Arvin C. Dar, 2017, Nature chemical biology.

An Allosteric Modulator of HIV-1 Protease Shows Equipotent Inhibition of Wild-Type and Drug-Resistant Proteases

H. Carlson, J. Dunbar, J. Gestwicki, 2014, Journal of medicinal chemistry.

SLC Transporters: Structure, Function, and Drug Discovery.

A. Schlessinger, P. Ung, C. Colas, 2016, MedChemComm.

Mutagenesis Reveals the Complex Relationships between ATPase Rate and the Chaperone Activities of Escherichia coli Heat Shock Protein 70 (Hsp70/DnaK)*

H. Carlson, J. Gestwicki, P. Ung, 2010, The Journal of Biological Chemistry.

Molecular Basis for Redox Activation of Epidermal Growth Factor Receptor Kinase.

Kate S. Carroll, A. Schlessinger, K. Carroll, 2016, Cell chemical biology.

Identification of a G-Protein-Independent Activator of GIRK Channels.

A. Zakharov, A. Schlessinger, A. Simeonov, 2020, Cell reports.

Exploiting allosteric properties of RAF and MEK inhibitors to target therapy-resistant tumors driven by oncogenic BRAF signaling.

D. Shaw, M. Herlyn, A. Schlessinger, 2021, Cancer discovery.

Type II Binders Targeting the "GLR-Out" Conformation of the Pseudokinase STRADα.

A. Schlessinger, P. Ung, A. Dar, 2021, Biochemistry.

DFGmodel: Predicting Protein Kinase Structures in Inactive States for Structure-Based Discovery of Type-II Inhibitors

A. Schlessinger, P. Ung, 2014, ACS chemical biology.

Encounter and React: Computer-Guided Design of Covalent Inhibitors.

A. Schlessinger, R. DeVita, P. Ung, 2019, Cell chemical biology.

A poke in the eye: inhibiting HIV-1 protease through its flap-recognition pocket.

H. Carlson, J. Gestwicki, P. Ung, 2008, Biopolymers.

An IRAK1-PIN1 Signalling Axis Drives Intrinsic Tumour Resistance to Radiation Therapy

R. White, A. Schlessinger, J. Heymach, 2018, Nature Cell Biology.

Automated genome mining for natural products

Peter Man-Un Ung, Sylvie Garneau-Tsodikova, David H. Sherman, 2009, BMC Bioinformatics.

Role of the CCAAT/Enhancer-binding Protein NFATc2 Transcription Factor Cascade in the Induction of Secretory Phospholipase A2*

P. Ung, C. Chow, M. Rincón, 2006, Journal of Biological Chemistry.

Structures of ligand-occupied β-Klotho complexes reveal a molecular mechanism underlying endocrine FGF specificity and activity

A. Schlessinger, E. Pardon, J. Steyaert, 2019, Proceedings of the National Academy of Sciences.

Binding of a small molecule at a protein-protein interface regulates the chaperone activity of hsp70-hsp40.

H. Carlson, P. Wipf, E. Zuiderweg, 2010, ACS chemical biology.

Integrated computational and Drosophila cancer model platform captures previously unappreciated chemicals perturbing a kinase network

Avner Schlessinger, Masahiro Sonoshita, Peter M U Ung, 2018, bioRxiv.

Dual targeting of salt inducible kinases and CSF1R uncouples bone formation and bone resorption

Daniel J. O'Connell, R. Xavier, M. Bouxsein, 2021, bioRxiv.

Chemical screens against a reconstituted multiprotein complex: myricetin blocks DnaJ regulation of DnaK through an allosteric mechanism.

H. Carlson, E. Zuiderweg, J. Gestwicki, 2011, Chemistry & biology.

Redefining the Protein Kinase Conformational Space with Machine Learning.

A. Schlessinger, P. Ung, Rayees Rahman, 2018, Cell chemical biology.

GEN3VA: aggregation and analysis of gene expression signatures from related studies

Avner Schlessinger, Avi Ma'ayan, Kathleen M. Jagodnik, 2016, BMC Bioinformatics.

CSAR Benchmark Exercise of 2010: Selection of the Protein–Ligand Complexes

Richard D. Smith, Heather A. Carlson, Shaomeng Wang, 2011, J. Chem. Inf. Model..

High resolution structure and inhibition of the schizophrenia-linked pseudokinase ULK4.

A. Schlessinger, P. Ung, M. Lazarus, 2019, Journal of the American Chemical Society.

Systems Pharmacology: An Overview

Avner Schlessinger, Jens Hansen, Ravi Iyengar, 2016 .

Identification of Key Hinge Residues Important for Nucleotide-Dependent Allostery in E. coli Hsp70/DnaK

Heather A. Carlson, Peter Man-Un Ung, Andrea D. Thompson, 2013, PLoS Comput. Biol..

Chemical probes that selectively recognize the earliest Aβ oligomers in complex mixtures.

H. Carlson, J. Gestwicki, P. Ung, 2010, Journal of the American Chemical Society.

Automated genome mining for natural products

D. Sherman, P. Ung, S. Garneau‐Tsodikova, 2009, BMC Bioinform..

CSAR Benchmark Exercise of 2010: Combined Evaluation Across All Submitted Scoring Functions

Richard D. Smith, Heather A. Carlson, Emilio Xavier Esposito, 2011, J. Chem. Inf. Model..

KinaMetrix: a web resource to investigate kinase conformations and inhibitor space

Avner Schlessinger, Peter Man-Un Ung, Rayees Rahman, 2018, Nucleic Acids Res..

Inhibitor Discovery for the Human GLUT1 from Homology Modeling and Virtual Screening.

A. Schlessinger, Hailin Hu, Ligong Chen, 2016, ACS chemical biology.

Mutagenesis Reveals the Complex Relationships between ATPase Rate and the Chaperone Activities of Escherichia coli Heat Shock Protein 70 (Hsp70/DnaK)*

H. Carlson, J. Gestwicki, P. Ung, 2010, The Journal of Biological Chemistry.

Human Mutation

A. Schlessinger, S. Yee, P. Ung, 2019 .