A. M. Giannetti

发表

Mechanism for Multiple Ligand Recognition by the Human Transferrin Receptor

Anthony M Giannetti, O. Zak, A. M. Giannetti, 2003, PLoS biology.

Structure of the BRAF-MEK complex reveals a kinase activity independent role for BRAF in MAPK signaling.

Ariana Peck, Alexandre Masselot, Anthony M Giannetti, 2014, Cancer cell.

Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

I. Mellman, Daniel J. Anderson, M. J. C. Ludlam, 2012, Proceedings of the National Academy of Sciences.

Docking for fragment inhibitors of AmpC β-lactamase

Denise G. Teotico, B. Shoichet, R. S. Ferreira, 2009, Proceedings of the National Academy of Sciences.

Comparative analysis of 10 small molecules binding to carbonic anhydrase II by different investigators using Biacore technology.

Yun Hee Cho, Siming Wang, Rosemarie Wilton, 2006, Analytical biochemistry.

Fragment-based discovery of hepatitis C virus NS5b RNA polymerase inhibitors.

Masaki Tomimoto, Charles Kissinger, Anthony M Giannetti, 2008, Bioorganic & medicinal chemistry letters.

Thermodynamics of calmodulin trapping by Ca2+/calmodulin-dependent protein kinase II: subpicomolar Kd determined using competition titration calorimetry.

J. M. Bradshaw, Anthony M Giannetti, A. M. Giannetti, 2007, Biochemistry.

De novo fragment design: a medicinal chemistry approach to fragment-based lead generation.

A. M. Giannetti, S. Harris, J. D. de Vicente, 2013, Journal of medicinal chemistry.

Surface plasmon resonance based assay for the detection and characterization of promiscuous inhibitors.

Anthony M Giannetti, A. M. Giannetti, M. Browner, 2008, Journal of medicinal chemistry.

The Synthesis of Biophysical Methods In Support of Robust Fragment‐Based Lead Discovery

B. Davis, A. M. Giannetti, 2016 .

Antagonists Induce a Conformational Change in cIAP1 That Promotes Autoubiquitination

S. Hymowitz, A. M. Giannetti, W. Fairbrother, 2011, Science.

Identification, characterization, and implications of species-dependent plasma protein binding for the oral Hedgehog pathway inhibitor vismodegib (GDC-0449).

Brandon J. Bravo, A. M. Giannetti, H. Wong, 2011, Journal of medicinal chemistry.

Effect of glycosylation on the function of a soluble, recombinant form of the transferrin receptor.

Igor A Kaltashov, Anthony M Giannetti, R. MacGillivray, 2006, Biochemistry.

Inhibitors of the Hepatitis C Virus Palm-Binding Nonnucleoside Polymerase Variants Dually Resistant to Thumb-and Selection and Characterization of Replicon

Than, C. Oshiro, A. M. Giannetti, 2006 .

1 Slow-binding inhibition and mechanism of resistance of non-nucleoside polymerase inhibitors of hepatitis C virus

A. M. Giannetti, S. Harris, S. Pogam, 2009 .

HFE and Transferrin Directly Compete for Transferrin Receptor in Solution and at the Cell Surface*

A. M. Giannetti, Pamela J. Björkman, 2004, Journal of Biological Chemistry.

Development of a Model Protein Interaction Pair as a Benchmarking Tool for the Quantitative Analysis of 2-Site Protein-Protein Interactions.

A. Yamniuk, M. Doyle, E. Eisenstein, 2015, Journal of biomolecular techniques : JBT.

Fragment-based identification of amides derived from trans-2-(pyridin-3-yl)cyclopropanecarboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).

Brandon J. Bravo, Qiang Zhao, N. Skelton, 2013, Journal of medicinal chemistry.

The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression.

N. Andrews, P. Bjorkman, A. M. Giannetti, 2008, Cell metabolism.

receptor 2 Heterotypic interactions between transferrin receptor and transferrin

P. Bjorkman, A. M. Giannetti, Aaron D. Blackwell, 2002 .

Docking for fragment inhibitors of AmpC (cid:1) -lactamase

B. Shoichet, R. S. Ferreira, G. Rocklin, 2009 .

Discovery of triazolinone non-nucleoside inhibitors of HIV reverse transcriptase.

Yu Li, Andrew Briggs, Klaus Klumpp, 2008, Bioorganic & medicinal chemistry letters.

Specific Btk inhibition suppresses B cell- and myeloid cell-mediated arthritis.

Brandon J. Bravo, L. Diehl, S. Hymowitz, 2011, Nature chemical biology.

Thermodynamic characterization of pyrazole and azaindole derivatives binding to p38 mitogen-activated protein kinase using Biacore T100 technology and van't Hoff analysis.

D. Myszka, A. M. Giannetti, N. Arora, 2008, Analytical biochemistry.

Selection and Characterization of Replicon Variants Dually Resistant to Thumb- and Palm-Binding Nonnucleoside Polymerase Inhibitors of the Hepatitis C Virus

Connie Oshiro, Klaus Klumpp, Anthony M. Giannetti, 2006, Journal of Virology.

Molecular Mechanism of the Syk Activation Switch*

Emily K. Tsang, J. M. Bradshaw, A. M. Giannetti, 2008, Journal of Biological Chemistry.

Identification of substituted 3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase.

BinQing Wei, M. Ultsch, C. Eigenbrot, 2014, Bioorganic & medicinal chemistry letters.

Identification of substituted 2-thio-6-oxo-1,6-dihydropyrimidines as inhibitors of human lactate dehydrogenase.

BinQing Wei, M. Ultsch, C. Eigenbrot, 2013, Bioorganic & medicinal chemistry letters.

Mutational analysis of the transferrin receptor reveals overlapping HFE and transferrin binding sites.

L. Weiner, A. West, P. Bjorkman, 2001, Journal of molecular biology.

From experimental design to validated hits a comprehensive walk-through of fragment lead identification using surface plasmon resonance.

Anthony M Giannetti, A. M. Giannetti, 2011, Methods in enzymology.

Slow Binding Inhibition and Mechanism of Resistance of Non-nucleoside Polymerase Inhibitors of Hepatitis C Virus

April Wong, Klaus Klumpp, Hannah J. Whittington, 2009, The Journal of Biological Chemistry.

Tailoring Small Molecules for an Allosteric Site on Procaspase‐6

Xianrui Zhao, Michelle R Arkin, Adam R Renslo, 2013, ChemMedChem.

Mechanistic and Structural Understanding of Uncompetitive Inhibitors of Caspase-6

Brandon J. Bravo, A. Renslo, M. Arkin, 2012, PloS one.

Heterotypic interactions between transferrin receptor and transferrin receptor 2.

P. Bjorkman, A. M. Giannetti, Aaron D. Blackwell, 2003, Blood.

Identification of 2-amino-5-aryl-pyrazines as inhibitors of human lactate dehydrogenase.

BinQing Wei, M. Ultsch, C. Eigenbrot, 2013, Bioorganic & medicinal chemistry letters.

A global benchmark study using affinity-based biosensors.

Yang Liu, Olan Dolezal, Eileen Lafer, 2009, Analytical biochemistry.

The molecular mechanism for receptor-stimulated iron release from the plasma iron transport protein transferrin.

Anthony M Giannetti, A. Mason, A. M. Giannetti, 2005, Structure.

Fragment-based identification and optimization of a class of potent pyrrolo[2,1-f][1,2,4]triazine MAP4K4 inhibitors.

Anthony M Giannetti, Ping Wu, Brandon J. Bravo, 2014, Bioorganic & medicinal chemistry letters.

Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).

Brandon J. Bravo, Qiang Zhao, N. Skelton, 2014, Bioorganic & medicinal chemistry letters.

Internal motions prime cIAP1 for rapid activation

T. Matsui, T. Weiss, J. Blankenship, 2014, Nature Structural &Molecular Biology.

Discovery of selective 4-Amino-pyridopyrimidine inhibitors of MAP4K4 using fragment-based lead identification and optimization.

Anthony M Giannetti, Ping Wu, Brandon J. Bravo, 2014, Journal of medicinal chemistry.

Composition of pH-sensitive triad in C-lobe of human serum transferrin. Comparison to sequences of ovotransferrin and lactoferrin provides insight into functional differences in iron release.

S. Everse, R. MacGillivray, A. Mason, 2005, Biochemistry.

Fibers of tau fragments, but not full length tau, exhibit a cross β‐structure: Implications for the formation of paired helical filaments

M. Radeke, A. M. Giannetti, S. Feinstein, 2000, Protein science : a publication of the Protein Society.

The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression.

N. Andrews, P. Bjorkman, A. M. Giannetti, 2008, Cell metabolism.

Fragment-based identification of amides derived from trans-2-(pyridin-3-yl)cyclopropanecarboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).

Brandon J. Bravo, Qiang Zhao, N. Skelton, 2013, Journal of medicinal chemistry.

Atom-Atom-Path similarity and Sphere Exclusion clustering: tools for prioritizing fragment hits

Huifen Chen, Man-Ling Lee, Alberto Gobbi, 2015, Journal of Cheminformatics.

CHAPTER 2:Getting the Most Value from Your Screens: Advances in Hardware, Software, and Methodologies to Enhance Surface Plasmon Resonance Based Fragment Screening and Hit-to-Lead Support

Donald P. Huddler, Mac Reiter, Anthony M. Giannetti, 2015 .